D. Klein

发表

The contribution of metal ions to the structural stability of the large ribosomal subunit.

T. Steitz, D. Klein, P. Moore, 2004, RNA.

The roles of ribosomal proteins in the structure assembly, and evolution of the large ribosomal subunit.

T. Steitz, D. Klein, P. Moore, 2004, Journal of molecular biology.

Structural Basis of glmS Ribozyme Activation by Glucosamine-6-Phosphate

A. Ferré-D’Amaré, D. Klein, 2006, Science.

Riboswitches: small-molecule recognition by gene regulatory RNAs.

A. Ferré-D’Amaré, D. Klein, T. Edwards, 2007, Current opinion in structural biology.

Estrogenic Activity in Commercial Food Packaging: Survey, Causes, and Cures

G. Bittner, D. Klein, S. Yaniger, 2011 .

Development of a selective HDAC inhibitor aimed at reactivating the HIV latent reservoir.

James I. Fells, D. Klein, R. Myers, 2020, Bioorganic & medicinal chemistry letters.

Structural understanding of non-nucleoside inhibition in an elongating herpesvirus polymerase

A. W. Shaw, Mee Ra Heo, I. Raheem, 2021, Nature Communications.

Targeting RNA with Small Molecules: Identification of Selective, RNA-Binding Small Molecules Occupying Drug-Like Chemical Space

Peter S. Kutchukian, Patrick J. Curran, Jeannie T. Lee, 2019, SLAS discovery : advancing life sciences R & D.

Redefining the Histone Deacetylase Inhibitor Pharmacophore: High Potency with No Zinc Cofactor Interaction

P. Coleman, Christopher D. Cox, D. Klein, 2021, ACS medicinal chemistry letters.

PharmGKB summary: gemcitabine pathway

Russ B. Altman, Teri E. Klein, Liewei Wang, 2014, Pharmacogenetics and genomics.

Structure of the Bacterial Deacetylase LpxC Bound to the Nucleotide Reaction Product Reveals Mechanisms of Oxyanion Stabilization and Proton Transfer

Sujata Sharma, D. Klein, K. Lumb, 2013, The Journal of Biological Chemistry.

Insights into activity and inhibition from the crystal structure of human O-GlcNAcase.

Sujata Sharma, D. Klein, D. Hall, 2017, Nature chemical biology.

Synthesis of polyphenylquinoxaline copolymers via aromatic nucleophilic substitution reactions of an A-B quinoxaline monomer

D. Klein, F. Harris, J. E. Korleski, 2001 .

Synthesis of poly(phenylquinoxaline)s via self-polymerizable quinoxaline monomers

D. Klein, D. Modarelli, F. Harris, 2001 .

Development of a new poly(phenylquinoxaline) for adhesive and composite applications

D. Klein, F. Harris, J. E. Korleski, 1999 .

Progress toward an understanding of the structure and enzymatic mechanism of the large ribosomal subunit.

T. Steitz, J. Hansen, N. Ban, 2001, Cold Spring Harbor symposia on quantitative biology.

Discovery of Highly Selective and Potent HDAC3 Inhibitors Based on a 2-Substituted Benzamide Zinc Binding Group.

D. Klein, M. Holloway, B. Howell, 2020, ACS medicinal chemistry letters.

Discovery of ethyl ketone-based HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation.

James I. Fells, D. Klein, R. Myers, 2020, Bioorganic & medicinal chemistry letters.

Selective Class I HDAC Inhibitors Based on Aryl Ketone Zinc Binding Induce HIV-1 Protein for Clearance.

James I. Fells, Joseph James Duffy, D. Klein, 2020, ACS medicinal chemistry letters.

Synthesis of poly(aryl ether phenylquinoxaline) via Ullmann ether condensation of chlorine-substituted A-B quinoxaline monomers

D. Klein, F. Harris, Bumjin Kim, 2001 .

Identification and in Vivo Evaluation of Liver X Receptor β-Selective Agonists for the Potential Treatment of Alzheimer's Disease.

K. K. Nanda, M. Rudd, J. Uslaner, 2016, Journal of medicinal chemistry.

SARS-CoV-2 tropism, entry, replication, and propagation: Considerations for drug discovery and development

D. Hazuda, D. Klein, A. Therien, 2021, PLoS pathogens.

Most Plastic Products Release Estrogenic Chemicals: A Potential Health Problem That Can Be Solved

George D. Bittner, V. Craig Jordan, Stuart I. Yaniger, 2011, Environmental health perspectives.

Continuously Substituted Solid Solutions of Organic Co-Crystals

D. Klein, M. Peterson, Mark A. Oliveira, 2008 .

Identification of potent inhibitors of the sortilin-progranulin interaction.

Gregory T O'Donnell, P. Coleman, M. Ziebell, 2020, Bioorganic & medicinal chemistry letters.

PharmGKB summary: tamoxifen pathway, pharmacokinetics

R. Altman, C. Thorn, T. Klein, 2013, Pharmacogenetics and genomics.

The NMR structure of the nucleocapsid protein from the mouse mammary tumor virus reveals unusual folding of the C-terminal zinc knuckle.

M. Summers, D. Klein, R. D. De Guzman, 2000, Biochemistry.

PharmGKB summary: isoniazid pathway, pharmacokinetics

R. Altman, E. McDonagh, C. Thorn, 2016, Pharmacogenetics and genomics.

Discovery of Selective RNA-Binding Small Molecules by Affinity-Selection Mass Spectrometry.

Ali Nahvi, Corey Strickland, J. Burchard, 2018, ACS chemical biology.

Discovery of 2-Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV-1 Integrase Strand Transfer Inhibitors.

John D. Schreier, Min Xu, D. Hazuda, 2015, Journal of medicinal chemistry.

Augmenting Hit Identification by Virtual Screening Techniques in Small Molecule Drug Discovery

Xin Cindy Yan, John Sanders, Ying Duo Gao, 2020, J. Chem. Inf. Model..

Cocrystal structure of a class I preQ1 riboswitch reveals a pseudoknot recognizing an essential hypermodified nucleobase

A. Ferré-D’Amaré, D. Klein, T. Edwards, 2009, Nature Structural &Molecular Biology.

Investigation of ionomers as dispersants for single wall carbon nanotubes

K. Watson, P. T. Lillehei, Joseph G. Smith, 2005 .

Synthesis and Characterization of Poly(pyridinium triflate)s with Alkyl and Aromatic Spacer Groups for Potential Use as Nonlinear Optic Materials

Tian-bing Xu, R. Bryant, D. Klein, 2005 .

Synthesis and Characterization of Polyimides Derived From Cyano-Containing 1,4-Bis(4-aminophenoxy)benzene Monomers

R. Bryant, D. Klein, 2007 .

Discovery of MK-8719, A Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies.

D. Klein, J. Hess, D. Vocadlo, 2019, Journal of medicinal chemistry.

Essential role of an active-site guanine in glmS ribozyme catalysis.

A. Ferré-D’Amaré, D. Klein, M. D. Been, 2007, Journal of the American Chemical Society.

Requirement of helix P2.2 and nucleotide G1 for positioning the cleavage site and cofactor of the glmS ribozyme.

A. Ferré-D’Amaré, D. Klein, Sara R. Wilkinson, 2007, Journal of molecular biology.

Crystallization of the glmS ribozyme-riboswitch.

A. Ferré-D’Amaré, D. Klein, Adrian R Ferré-D'Amaré, 2009, Methods in molecular biology.

Cocrystal structure of a class-I preQ1 riboswitch

A. Ferré-D’Amaré, D. Klein, T. Edwards, 2009 .

Discovery of a Distinct Chemical and Mechanistic Class of Allosteric HIV-1 Integrase Inhibitors with Antiretroviral Activity.

Mee Ra Heo, Min Xu, Sujata Sharma, 2017, ACS chemical biology.

Discovery of arylsulfonamides as a novel class of allosteric integrase inhibitors with antiviral activity.

Adam R. Johnson, Sujata Sharma, D. Klein, 2023, Bioorganic & medicinal chemistry letters.

Discovery and optimization of 2-pyridinone aminal integrase strand transfer inhibitors for the treatment of HIV.

John D. Schreier, Min Xu, D. Hazuda, 2017, Bioorganic & medicinal chemistry letters.

Correction to Discovery of 2-Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV-1 Integrase Strand Transfer Inhibitors.

John D. Schreier, Min Xu, D. Hazuda, 2016, Journal of Medicinal Chemistry.

Cocrystal structure of a class I preQ1 riboswitch reveals a pseudoknot recognizing an essential hypermodified nucleobase

A. Ferré-D’Amaré, D. Klein, T. Edwards, 2009, Nature Structural &Molecular Biology.