H. Lipps

发表

The unusual way to make a genetically active nucleus.

F. Jönsson, J. Postberg, H. Lipps, 2009, DNA and cell biology.

Towards safe, non-viral therapeutic gene expression in humans

H. Lipps, Dominic J. Glover, D. Jans, 2005, Nature Reviews Genetics.

Generation of a tumor- and tissue-specific episomal non-viral vector system

A. Baiker, F. Kopp, H. Lipps, 2013, BMC Biotechnology.

An episomal mammalian replicon: sequence‐independent binding of the origin recognition complex

H. Lipps, Jens Baltin, D. Schaarschmidt, 2004, The EMBO journal.

Nuclear scaffold/matrix attached region modules linked to a transcription unit are sufficient for replication and maintenance of a mammalian episome.

A. Baiker, H. Lipps, T. Eisenberger, 2004, Proceedings of the National Academy of Sciences of the United States of America.

G-quadruplexes and their regulatory roles in biology

H. Lipps, D. Rhodes, 2015, Nucleic acids research.

Telomere end-binding proteins control the formation of G-quadruplex DNA structures in vivo

Jan Postberg, Daniela Rhodes, Katrin Paeschke, 2005, Nature Structural &Molecular Biology.

Higher order DNA structure in macronuclear chromatin of the hypotrichous ciliate Oxytricha nova.

W. Gruissem, D. Prescott, H. Lipps, 1982, Proceedings of the National Academy of Sciences of the United States of America.

The nonviral episomal replicating vector pEPI-1 allows long-term inhibition of bcr-abl expression by shRNA.

A. Baiker, H. Lipps, T. Eisenberger, 2005, Human gene therapy.

Expression of a transgene encoded on a non-viral episomal vector is not subject to epigenetic silencing by cytosine methylation

H. Lipps, I. Stehle, A. Jenke, 2004, Molecular Biology Reports.

Long-Term Suppression of Hepatitis B Virus Replication by Short Hairpin RNA Expression Using the Scaffold/Matrix Attachment Region-Based Replicating Vector System pEPI-1

H. Lipps, U. Protzer, S. Wirth, 2008, Antimicrobial Agents and Chemotherapy.

Antibodies against Z DNA react with the macronucleus but not the micronucleus of the hypotrichous ciliate stylonychia mytilus

Alfred Nordheim, Alexander Rich, A. Rich, 1983, Cell.

Telomeric interactions result in the formation of intramolecular circles behaving as topologically constrained.

H. Lipps, F. Azorín, S. Feiler, 1998, Journal of molecular biology.

Chromatin structure in the macronucleus of the ciliate Stylonychia mytilus.

H. Lipps, M. Riewe, G. Steinbrück, 1978, Nucleic acids research.

In vitro aggregation of the gene-sized DNA molecules of the ciliate Stylonychia mytilus.

H. Lipps, 1980, Proceedings of the National Academy of Sciences of the United States of America.

Stereo-electron microscopy of nuclear structure and replication in ciliated protozoa (Hypotricha).

D. E. Olins, D. Prescott, H. Lipps, 1981, European journal of cell biology.

Probing telomeric G-quadruplex DNA structures in cells with in vitro generated single-chain antibody fragments.

J. Postberg, H. Lipps, C. Schaffitzel, 2010, Methods in molecular biology.

Guanine quadruplex structures localize to heterochromatin

R. Hoffmann, B. Giepmans, Eugene Berezikov, 2017, Nucleic Acids Research.

Guanine quadruplex structures localize to heterochromatin

R. Hoffmann, B. Giepmans, Eugene Berezikov, 2015, Nucleic acids research.

Organization of the macronuclear gene-sized pieces of stichotrichous ciliates into a higher order structure via telomere–matrix interactions

F. Jönsson, J. Postberg, H. Lipps, 2004, Chromosome Research.

New insights into the macronuclear development in ciliates.

H. Lipps, S. Juranek, 2007, International review of cytology.

Interconversion of Germline-Limited and Somatic DNA in a Scrambled Gene

Andre R. O. Cavalcanti, L. Landweber, F. Jönsson, 2006, Journal of Molecular Evolution.

Telomerase recruitment by the telomere end binding protein-β facilitates G-quadruplex DNA unfolding in ciliates

H. Lipps, D. Rhodes, S. Juranek, 2008, Nature Structural &Molecular Biology.

Synthesis of pre-rRNA and mRNA is directed to a chromatin-poor compartment in the macronucleus of the spirotrichous ciliate Stylonychia lemnae

J. Postberg, H. Lipps, O. Alexandrova, 2006, Chromosome Research.

In vivo studies on non-viral transdifferentiation of liver cells towards pancreatic β cells.

H. Lipps, Haibin Su, L. Collins, 2012, The Journal of endocrinology.

De novo cytosine methylation in the differentiating macronucleus of the stichotrichous ciliate Stylonychia lemnae.

H. Wieden, H. Lipps, S. Juranek, 2003, Nucleic acids research.

RNA-dependent control of gene amplification

F. Jönsson, H. Lipps, Wei Chang, 2010, Proceedings of the National Academy of Sciences.

RNA-template dependent de novo telomere addition

F. Jönsson, J. Postberg, H. Lipps, 2016, RNA biology.

Template activity of macronuclear and micronuclear chromatin of the ciliate Stylonychia mytilus.

H. Lipps, M. Riewe, 1977, Cell biology international reports.

Episomal vectors for gene therapy.

A. Baiker, H. Lipps, A. Schepers, 2008, Current gene therapy.

A Novel Adenoviral Hybrid-vector System Carrying a Plasmid Replicon for Safe and Efficient Cell and Gene Therapeutic Applications

A. Baiker, H. Lipps, Wenli Zhang, 2013, Molecular therapy. Nucleic acids.

Cell cycle-dependent regulation of telomere tethering in the nucleus

H. Lipps, D. Rhodes, S. Juranek, 2008, Chromosome Research.

An episomally replicating vector binds to the nuclear matrix protein SAF‐A in vivo

F. Jönsson, H. Lipps, F. O. Fackelmayer, 2002, EMBO reports.

A macronuclear DNA molecule from the hypotrichous ciliate Stylonychia lemnae encoding a t-complex polypeptide 1-like protein.

H. Lipps, C. Maercker, 1994, Gene.

Genomic cis-acting Sequences Improve Expression and Establishment of a Nonviral Vector

H. Lipps, M. Antoniou, C. Hagedorn, 2013, Molecular therapy. Nucleic acids.

Genetically modified pigs produced with a nonviral episomal vector

M. Papa, H. Lipps, M. Cerrito, 2006, Proceedings of the National Academy of Sciences.

The organization of macronuclear DNA sequences associated with C4A4 repeats in the polytene chromosomes of Stylonychia lemnae

M. Schmid, H. Lipps, S. Stoll, 1991, Chromosoma.

Free genes for rRNAs in the macronuclear genome of the ciliate Stylonychia mytilus

H. Lipps, G. Steinbrück, 1978, Chromosoma.

Establishment and mitotic stability of an extra-chromosomal mammalian replicon

T. Cremer, J. Postberg, H. Lipps, 2007, BMC Cell Biology.

Isolation and functional property of mRNAs coding for human interleukin 2.

P. Wernet, H. Lipps, H. Schott, 1984, Cell biology international reports.

The Pathway to Detangle a Scrambled Gene

Grzegorz Rozenberg, Laura F. Landweber, Thomas G. Doak, 2008, PloS one.

Limited sequence polymorphism in the Plasmodium falciparum merozoite surface protein 3.

H. Lipps, I. Felger, H. Matile, 1997, Molecular and biochemical parasitology.

A telomere binding protein in the macronuclei of the hypotrichous ciliate Stylonychia lemnae

H. Lipps, W. Steinhilber, 1986 .

A linear shuttle vector for yeast and the hypotrichous ciliate Stylonychia.

H. Lipps, F. Ascenzioni, 1986, Gene.

Chromosome-based vectors for gene therapy.

H. Lipps, J. Bode, A. Jenke, 2003, Gene.

Fast-sorting system for cells with high-copy-number expression vectors and its use for the modulation of CML cells.

H. Lipps, U. Weidle, F. Grummt, 1998, Advances in experimental medicine and biology.

The use of RNAi to analyze gene function in spirotrichous ciliates

Jan Postberg, Katrin Paeschke, F. Jönsson, 2003 .

The Euplotes La motif protein p43 has properties of a telomerase-specific subunit.

T. Cech, J. Postberg, H. Lipps, 2003, Biochemistry.

The telomerase-associated protein p43 is involved in anchoring telomerase in the nucleus

F. Jönsson, J. Postberg, H. Lipps, 2003, Journal of Cell Science.

Native yeast telomeres are sufficient to stabilize linear DNA in Xenopus laevis oocytes.

M. Schmid, H. Lipps, H. Steinbeisser, 1991, Gene.

Inhibition of HIV-1 replication by a high-copy-number vector expressing antisense RNA for reverse transcriptase.

H. Lipps, S. Nick, F. Grummt, 1993, Gene.

[Lifelong healing via gene transfer - reality or utopia? Stable versus transient gene transfer].

H. Lipps, W. Hammerschmidt, A. Ehrhardt, 2011, Pharmazie in unserer Zeit.

A gene from the hypotrichous ciliate Stylonychia lemnae coding for a protein with homology to cyclin B.

H. Lipps, C. Maercker, 1994, Gene.

The two macronuclear histone H4 genes of the hypotrichous ciliate Stylonychia lemnae.

H. Lipps, I. Wefes, 1990, DNA sequence : the journal of DNA sequencing and mapping.

A nuclear protein involved in apoptotic-like DNA degradation in Stylonychia: implications for similar mechanisms in differentiating and starved cells.

C. Allis, H. Lipps, M. Nikiforov, 1999, Molecular biology of the cell.

pEPI for Gene Therapy Non viral episomes and their Application in Somatic Gene Therapy

H. Lipps, C. Hagedorn, 2013 .

Restoration of membrane excitability by microinjection of cytoplasmic wild-type RNA into Paramecium tetraurelia pawn C mutants

H. Lipps, J. Schultz, A. Nock, 1982 .

Translation of homologous RNA injected into the ciliate Stylonychia mytilus.

H. Lipps, J. Knowles, A. Nock, 1978, Biochemical and biophysical research communications.

In vitro generated antibodies specific for telomeric guanine-quadruplex DNA react with Stylonychia lemnae macronuclei

I Berger, A. Plückthun, J. Postberg, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Controlled removal of a nonviral episomal vector from transfected cells.

H. Lipps, M. Ogris, E. Wagner, 2010, Gene.

pEPito: a significantly improved non-viral episomal expression vector for mammalian cells

A. Baiker, J. Haas, H. Lipps, 2010, BMC biotechnology.

Nonviral Delivery of the Rat PDX1 Gene to Rat Liver For the In Vivo Transdifferentiation of Liver Cells to Pancreatic Beta-Cells

H. Lipps, Haibin Su, L. Collins, 2010 .

Exploiting a minimal system to study the epigenetic control of DNA replication: the interplay between transcription and replication

A. Baiker, H. Lipps, A. Jenke, 2004, Chromosome Research.

Mitotic stability of an episomal vector containing a human scaffold/matrix-attached region is provided by association with nuclear matrix

A. Baiker, H. Lipps, C. Benham, 2000, Nature Cell Biology.

A vector based on the SV40 origin of replication and chromosomal S/MARs replicates episomally in CHO cells.

A. Baiker, H. Lipps, J. Bode, 1999, Nucleic acids research.

Concanavalin A-induced nuclear division in Stylonychia mytilus.

W. Bessler, H. Lipps, 1976, Journal of general microbiology.

The genome of hypotrichous ciliates.

D. Prescott, H. Lipps, H. Kraut, 1986, International review of cytology.

G-quadruplex structures: in vivo evidence and function.

Daniela Rhodes, H. Lipps, D. Rhodes, 2009, Trends in cell biology.

Copy number variations of 11 macronuclear chromosomes and their gene expression in Oxytricha trifallax.

H. Lipps, Ke Xu, E. Swart, 2012, Gene.

The Draft Assembly of the Radically Organized Stylonychia lemnae Macronuclear Genome

Estienne C. Swart, Jan Postberg, F. Jönsson, 2014, Genome biology and evolution.

A PIWI homolog is one of the proteins expressed exclusively during macronuclear development in the ciliate Stylonychia lemnae.

H. Lipps, Daniel J Hogan, C. Fetzer, 2002, Nucleic acids research.

RNA-dependent genome processing during nuclear differentiation: the model systems of stichotrichous ciliates.

H. Lipps, M. Nowacki, E. Swart, 2013, Epigenomics.

Designing nonviral vectors for efficient gene transfer and long-term gene expression.

H. Lipps, D. Jackson, S. Juranek, 2006, Molecular therapy : the journal of the American Society of Gene Therapy.

An expression vector inhibits gene expression in Xenopus embryos by antisense RNA

M. Schmid, H. Lipps, H. Steinbeisser, 1992, Roux's archives of developmental biology.

Evolutionary origin of the cell nucleus and its functional architecture.

T. Cremer, J. Postberg, H. Lipps, 2010, Essays in biochemistry.

27nt-RNAs guide histone variant deposition via ‘RNA-induced DNA replication interference’ and thus transmit parental genome partitioning in Stylonychia

F. Jönsson, J. Postberg, H. Lipps, 2018, Epigenetics & Chromatin.

Differential expression of histone H3 genes and selective association of the variant H3.7 with a specific sequence class in Stylonychia macronuclear development

F. Jönsson, J. Postberg, H. Lipps, 2014, Epigenetics & Chromatin.

A permissive chromatin structure is adopted prior to site-specific DNA demethylation of developmentally expressed genes involved in macronuclear differentiation

F. Jönsson, J. Postberg, H. Lipps, 2013, Epigenetics & Chromatin.

Overcoming Barriers to Achieve Safe, Sustained and Efficient Non-Viral Gene Therapy

H. Lipps, Dominic J. Glover, D. Jans, 2007 .

S/MAR sequence confers long-term mitotic stability on non-integrating lentiviral vector episomes without selection

H. Lipps, P. Kurre, Natalya A Goloviznina, 2014, Nucleic acids research.

Scaffold/matrix attached region-based nonviral episomal vectors.

H. Lipps, S. Wong, R. Harbottle, 2011, Human gene therapy.

Handling S/MAR vectors.

A. Baiker, J. Postberg, H. Lipps, 2012, Cold Spring Harbor protocols.

Spatial and temporal plasticity of chromatin during programmed DNA-reorganization in Stylonychia macronuclear development

T. Cremer, J. Postberg, H. Lipps, 2008, Epigenetics & Chromatin.

Genome-wide profiling of S/MAR-based replicon contact sites

H. Lipps, J. Epplen, A. Gogol-Döring, 2017, Nucleic acids research.

snRNA and Heterochromatin Formation Are Involved in DNA Excision during Macronuclear Development in Stichotrichous Ciliates

J. Postberg, H. Lipps, S. Juranek, 2005, Eukaryotic Cell.

The evolutionary history of histone H3 suggests a deep eukaryotic root of chromatin modifying mechanisms

Jan Postberg, J. Postberg, H. Lipps, 2010, BMC Evolutionary Biology.

The epigenetic regulation of autonomous replicons

H. Lipps, C. Hagedorn, Sina Rupprecht, 2010, Biomolecular concepts.

27nt-RNAs guide histone variant deposition via ‘RNA-induced DNA replication interference’ and thus transmit parental genome partitioning in Stylonychia

F. Jönsson, J. Postberg, H. Lipps, 2018, Epigenetics & Chromatin.

Association of the telomere-telomere-binding protein complex of hypotrichous ciliates with the nuclear matrix and dissociation during replication.

F. Jönsson, J. Postberg, H. Lipps, 2001, Journal of cell science.

Mammalian artificial chromosomes--vectors for somatic gene therapy.

H. Lipps, F. Ascenzioni, P. Donini, 1997, Cancer letters.

Cell cycle dependent histone dynamics of an episomal non-viral vector.

H. Lipps, Sina Rupprecht, 2009, Gene.

S/MAR VECTORS — ALTERNATIVE EXPRESSION SYSTEMS FOR GENE THERAPY?

H. Lipps, C. Hagedorn, 2012 .

Macronucleus structure and macronucleus development in hypotrichous ciliates.

H. Lipps, C. Eder, 1996, The International journal of developmental biology.

Characterization of the Structural Conformation Adopted by (TTAGGG)(n) Telomeric DNA Repeats of Different Length in Closed Circular DNA.

H. Lipps, F. Azorín, D. Huertas, 1994, Journal of biomolecular structure & dynamics.

The organization of internal telomeric repeats in the polytene chromosomes of the hypotrichous ciliate Stylonychia lemnae.

H. Lipps, C. Maercker, S. Stoll, 1993, Nucleic acids research.

Separation of micronuclear DNA of Stylonychia lemnae by pulsed-field electrophoresis and identification of a DNA molecule with a high copy number.

H. Lipps, C. Maercker, H. Kortwig, 1999, Genome research.

A subtelomeric DNA sequence is required for correct processing of the macronuclear DNA sequences during macronuclear development in the hypotrichous ciliate Stylonychia lemnae.

F. Jönsson, H. Lipps, C. Fetzer, 1999, Nucleic Acids Research.

Analysis of the subtelomeric regions of macronuclear gene-sized DNA molecules of the hypotrichous ciliate Stylonychia lemnae: implications for the DNA fragmentation process during macronuclear development?

H. Lipps, C. Maercker, 1993, Developmental genetics.

Both subtelomeric regions are required and sufficient for specific DNA fragmentation during macronuclear development in Stylonychia lemnae

F. Jönsson, H. Lipps, G. Steinbrück, 2001, Genome Biology.

Exploiting nuclear duality of ciliates to analyse topological requirements for DNA replication and transcription

T. Cremer, J. Postberg, H. Lipps, 2005, Journal of Cell Science.

The processing of macronuclear DNA sequences during macronuclear development of the hypotrichous ciliate Stylonychia lemnae.

H. Lipps, C. Maercker, C. Eder, 1993, The International journal of developmental biology.

Immobilization of Ciliates by Concanavalin A

W. Bessler, H. Lipps, D. Ammermann, 1976 .

Electron microscopy of surface spread polytene chromosomes of Drosophila and Stylonychia

H. Lipps, G. F. Meyer, H. J. Lipps, 1984, Chromosoma.

Chromatin elimination in the hypotrichous ciliate Stylonychia mytilus

H. Lipps, G. F. Meyer, H. J. Lipps, 2004, Chromosoma.

A colony-forming assay for determining the establishment efficiency of S/MAR-containing nonviral episomal expression vectors.

A. Baiker, J. Postberg, H. Lipps, 2012, Cold Spring Harbor protocols.

A reverse transcriptase like enzyme in the developing macronucleus of the hypotrichous ciliateStylonychia

H. Lipps, 1985, Current Genetics.

The Formation of New Nucleoli During Macronuclear Development of the Hypotrichous Ciliate Stylonychia lemnae Visualized by in situ Hybridization

H. Lipps, M. Neben, H. Niemann, 1997, Chromosome Research.

The formation of polytene chromosomes during macronuclear development of the hypotrichous ciliate Stylonychia mytilus

H. Lipps, G. F. Meyer, H. J. Lipps, 2004, Chromosoma.

Studies on the histones of the ciliate Stylonychia mytilus

H. Lipps, K. Hantke, 1975, Chromosoma.

The histones of the ciliated protozoan Stylonychia mytilus

H. Lipps, D. Ammermann, G. R. Sapra, 1974, Chromosoma.

Chromatin structure in the nuclei of the ciliate stylonychia mytilus.

H. Lipps, N. Morris, 1977, Biochemical and biophysical research communications.

Sequential excision of internal eliminated DNA sequences in the differentiating macronucleus of the hypotrichous ciliate Stylonychia lemnae.

H. Lipps, H J Lipps, C. Maercker, 1996, Nucleic acids research.

A telomerase-associated RecQ protein-like helicase resolves telomeric G-quadruplex structures during replication

J. Postberg, H. Lipps, D. Rhodes, 2012, Gene.

Histone genes in macronuclear DNA of the ciliate Stylonychia mytilus

H. Lipps, G. Steinbrück, S. Elsevier, 1978, Chromosoma.

The telomeres of replicating macronuclear DNA-molecules of the hypotrichous ciliate Stylonychia lemnae

F. Jönsson, H. Lipps, S. Juranek, 2000 .

Expression of Concern: Guanine quadruplex structures localize to heterochromatin

R. Hoffmann, B. Giepmans, P. Lansdorp, 2017 .

Early nuclear events following the interaction of the ciliate Stylonychia mytilus with the plant lectin concanavalin a

W. Bessler, H. Lipps, 1977 .

An analysis of the phenol-soluble nuclear proteins in the ciliate Stylonychia mytilus

H. Lipps, 1977 .

Differential expression of histone H3 genes and selective association of the variant H3.7 with a specific sequence class in Stylonychia macronuclear development

F. Jönsson, J. Postberg, H. Lipps, 2014, Epigenetics & Chromatin.

DNase I hypersensitivity of the terminal inverted repeat DNA sequences in the macronucleus of the ciliate Stylonychia mytilus

H. Lipps, Petra Erhardt, 1981, FEBS letters.

The processing of macronuclear-destined DNA sequences microinjected into the macronuclear anlagen of the hypotrichous ciliate Stylonchia lemnae.

H. Lipps, C. Eder, J. Wen, 1995, Nucleic acids research.

Viral hybrid-vectors for delivery of autonomous replicons.

H. Lipps, Wenli Zhang, A. Ehrhardt, 2014, Current gene therapy.

Characterization of a family of repetitive sequences that is eliminated late during macronuclear development of the hypotrichous ciliate Stylonychia lemnae.

H. Lipps, E. Becker, C. Maercker, 1997, Developmental genetics.