S. Weiler

发表

Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c

S. Korsmeyer, M. Wei, M. Saito, 2000, Cell Death and Differentiation.

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics.

S. Korsmeyer, A. Letai, S. Weiler, 2002, Cancer cell.

Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response

S. Weiler, Jian Ding, W. Schamel, 2019, Nature Communications.

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis.

S. Korsmeyer, T. Mak, E. Cheng, 2001, Molecular cell.

Identification of the neurotrophic factor sequence of prosaposin

S. Weiler, Y. Kishimoto, J. Tomich, 1995, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Solution structure of human saposin C: pH-dependent interaction with phospholipid vesicles.

N. Tjandra, S. Weiler, E. de Alba, 2003, Biochemistry.

Interaction of saposins, acidic lipids, and glucosylceramidase.

S. Weiler, K. Kretz, Y. Kishimoto, 1990, The Journal of biological chemistry.

MAP 3 K 11 / GDF 15 axis is a critical driver of cancer cachexia

A. Vigano, Richard Nicoletti, S. Weiler, 2015 .

Structural basis of an embryonically lethal single Ala --> Thr mutation in the vnd/NK-2 homeodomain.

M. Nirenberg, S. Weiler, J. Ferretti, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Sequence of two alleles responsible for Gaucher disease.

S. Weiler, J. Barranger, T. Ohashi, 1990, DNA and cell biology.

Anticorps anti-ron

S. Weiler, J. Gyuris, L. Lerner, 2011 .

Expression studies and mutational analysis of the androgen regulated homeobox gene NKX3.1 in benign and malignant prostate epithelium.

D. Ornstein, W. M. Linehan, M. Emmert-Buck, 2001, The Journal of urology.

Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors.

S. Weiler, B. Brandhuber, G. Vigers, 2008, Bioorganic & medicinal chemistry letters.

A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis.

Luca Scorrano, Carmen A Mannella, S. Korsmeyer, 2002, Developmental cell.

Saposins (Sphingolipid Activator Proteins) in the Twitcher Mutant Mouse

S. Weiler, Y. Kishimoto, S. Morimoto, 1990, Journal of neurochemistry.

Characterization of human glucocerebrosidase from different mutant alleles.

S. Weiler, J. Tomich, J. Barranger, 1991, The Journal of biological chemistry.

Identification of the binding and activating sites of the sphingolipid activator protein, saposin C, with glucocerebrosidase

S. Weiler, Y. Kishimoto, J. Tomich, 1995, Protein science : a publication of the Protein Society.

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c.

V. Mootha, S. Korsmeyer, M. Ashiya, 2000, Genes & development.

23814, an Inhibitory Antibody of Ligand-Mediated Notch1 Activation, Modulates Angiogenesis and Inhibits Tumor Growth without Gastrointestinal Toxicity

Richard Nicoletti, L. Poling, S. Weiler, 2015, Molecular Cancer Therapeutics.

Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis.

S. Korsmeyer, J. Zha, M. Wei, 2000, Science.

Neuregulin 1 Expression Is a Predictive Biomarker for Response to AV-203, an ERBB3 Inhibitory Antibody, in Human Tumor Models

Richard Nicoletti, S. Weiler, J. Gyuris, 2014, Clinical Cancer Research.

GP369, an FGFR2-IIIb-specific antibody, exhibits potent antitumor activity against human cancers driven by activated FGFR2 signaling.

Nhi N. Y. Vo, L. Poling, S. Weiler, 2010, Cancer research.

MAP3K11/GDF15 axis is a critical driver of cancer cachexia

A. Vigano, Richard Nicoletti, S. Weiler, 2015, Journal of cachexia, sarcopenia and muscle.

Molecular biology of glucocerebrosidase and the treatment of Gaucher disease.

S. Weiler, J. Tomich, A. Bahnson, 1995, Cytokines and molecular therapy.

Position of the sulfhydryl group and the disulfide bonds of human glucocerebrosidase

S. Weiler, J. Tomich, J. Barranger, 1995, Journal of protein chemistry.

Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response

S. Weiler, Jian Ding, W. Schamel, 2019, Nature Communications.

2LB Anti-tumor activity of anti-RON antibodies and biomarker of response

S. Weiler, J. Gyuris, K. Whalen, 2010 .

Site-directed Mutations in the vnd/NK-2 Homeodomain

M. Nirenberg, S. Weiler, J. Ferretti, 1998, The Journal of Biological Chemistry.

Synthesis and characterization of a bioactive 82-residue sphingolipid activator protein, saposin C

D. Teplow, S. Weiler, Y. Kishimoto, 2007, Journal of Molecular Neuroscience.

Prodrug thiamine analogs as inhibitors of the enzyme transketolase.

S. Weiler, C. Lemieux, Stephen S. Gonzales, 2008, Bioorganic & medicinal chemistry letters.

Abstract 2509: AV-203, a humanized ERBB3 inhibitory antibody inhibits ligand-dependent and ligand-independent ERBB3 signaling in vitro and in vivo

S. Weiler, J. Gyuris, S. Bottega, 2012 .

Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors.

S. Weiler, B. Brandhuber, G. Vigers, 2008, Bioorganic & medicinal chemistry letters.