M. Ferraroni

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Structural basis of hyaluronan degradation by Streptococcus pneumoniae hyaluronate lyase

Songlin Li, S. Kelly, E. Lamani, 2000, The EMBO journal.

M. Ferraroni, F. Briganti, 2009 .

Crystal Structure of 4-Chlorocatechol 1,2-Dioxygenase from the Chlorophenol-utilizing Gram-positive Rhodococcus opacus 1CP*

A. Scozzafava, M. Ferraroni, I. Solyanikova, 2004, Journal of Biological Chemistry.

4-Chlorocatechol 1,2-dioxygenase from the chlorophenol-utilizing Gram-positive Rhodococcus opacus 1CP: crystallization and preliminary crystallographic analysis.

A. Scozzafava, M. Ferraroni, S. Mangani, 2002, Acta crystallographica. Section D, Biological crystallography.

Bmc Structural Biology Crystal Structure of a Blue Laccase from Lentinus Tigrinus: Evidences for Intermediates in the Molecular Oxygen Reductive Splitting by Multicopper Oxidases

A. Scozzafava, M. Ferraroni, L. Golovleva, 2007 .

Laccase isoforms with unusual properties from the basidiomycete Steccherinum ochraceum strain 1833

A. Scozzafava, M. Ferraroni, N. Myasoedova, 2008, Journal of applied microbiology.

Crystal structure of the blue multicopper oxidase from the white-rot fungus Trametes trogii complexed with p-toluate

A. Scozzafava, M. Ferraroni, A. Gullotto, 2008 .

Synthesis and cholinergic affinity of diastereomeric and enantiomeric isomers of 1-methyl-2-(2-methyl-1,3-dioxolan-4-yl)- pyrrolidine, 1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine and of Their iodomethylates.

M. Buccioni, M. Ferraroni, R. Matucci, 2003, Bioorganic & medicinal chemistry.

Polymeric hydrophobic membranes as a tool to control polymorphism and protein–ligand interactions

Enrico Drioli, Efrem Curcio, Gianluca Di Profio, 2006 .

[Au(9-methylcaffein-8-ylidene)2 ]+ /DNA Tel23 System: Solution, Computational, and Biological Studies.

M. Ferraroni, D. Colangelo, L. Massai, 2017, Chemistry.

Sulfonamide Diuretic Azosemide as an Efficient Carbonic Anhydrase Inhibitor

C. Supuran, M. Ferraroni, M. Pinteala, 2022, Journal of Molecular Structure.

Crystal Structure of a Tetrameric Type II β-Carbonic Anhydrase from the Pathogenic Bacterium Burkholderia pseudomallei

C. Supuran, M. Ferraroni, C. Capasso, 2020, Molecules.

Crystal structure and chemical inhibition of essential schistosome host-interactive virulence factor carbonic anhydrase SmCA

C. Supuran, M. Ferraroni, A. Angeli, 2019, Communications Biology.

2-Benzylpiperazine: A new scaffold for potent human carbonic anhydrase inhibitors. Synthesis, enzyme inhibition, enantioselectivity, computational and crystallographic studies and in vivo activity for a new class of intraocular pressure lowering agents.

C. Supuran, E. Masini, M. Ferraroni, 2018, European journal of medicinal chemistry.

Crystal analysis of aromatic sulfonamide binding to native and (Zn)2 adduct of human carbonic anhydrase I Michigan 1

C. Supuran, A. Scozzafava, M. Ferraroni, 2002 .

Polypharmacology of epacadostat: a potent and selective inhibitor of the tumor associated carbonic anhydrases IX and XII.

C. Supuran, M. Ferraroni, A. Angeli, 2019, Chemical communications.

Anion inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.

C. Supuran, M. Ferraroni, D. Vullo, 2016, Bioorganic & medicinal chemistry letters.

Crystallization and preliminary X-ray crystallographic analysis of the small subunit of the heterodimeric laccase POXA3b from Pleurotus ostreatus.

A. Scozzafava, M. Ferraroni, S. Ullah, 2014, Acta crystallographica. Section F, Structural biology communications.

Crystallization and preliminary X-ray crystallographic analysis of hydroquinone dioxygenase from Sphingomonas sp. TTNP3.

A. Scozzafava, M. Ferraroni, B. Kolvenbach, 2012, Acta crystallographica. Section F, Structural biology and crystallization communications.

Pyridine Derivative of the Natural Alkaloid Berberine as Human Telomeric G4-DNA Binder: A Solution and Solid-State Study.

M. Ferraroni, G. S. Kumar, P. Lombardi, 2020, ACS medicinal chemistry letters.

Induction of a Four‐Way Junction Structure in the DNA Palindromic Hexanucleotide 5′‐d(CGTACG)‐3′ by a Mononuclear Platinum Complex

M. Ferraroni, L. Messori, B. Siewert, 2019, Angewandte Chemie.

Crystallization and preliminary structure analysis of the blue laccase from the ligninolytic fungus Panus tigrinus.

A. Scozzafava, M. Ferraroni, L. Golovleva, 2005, Acta crystallographica. Section F, Structural biology and crystallization communications.

Function of different amino acid residues in the reaction mechanism of gentisate 1,2-dioxygenases deduced from the analysis of mutants of the salicylate 1,2-dioxygenase from Pseudaminobacter salicylatoxidans.

M. Ferraroni, A. Stolz, Lenz Steimer, 2015, Biochimica et biophysica acta.

Probing the Efficiency of 13-Pyridylalkyl Berberine Derivatives to Human Telomeric G-Quadruplexes Binding: Spectroscopic, Solid State and In Silico Analysis

M. Ferraroni, P. Lombardi, P. Gratteri, 2022, International journal of molecular sciences.

Design, synthesis, biological evaluation and crystal structure determination of dual modulators of carbonic anhydrases and estrogen receptors.

G. Rastelli, J. Nwachukwu, K. Nettles, 2022, European journal of medicinal chemistry.

Sulfonamides incorporating piperazine bioisosteres as potent human carbonic anhydrase I, II, IV and IX inhibitors.

C. Supuran, M. Ferraroni, Niccolò Chiaramonte, 2019, Bioorganic chemistry.

Benzenesulfonamides Incorporating Flexible Triazole Moieties Are Highly Effective Carbonic Anhydrase Inhibitors: Synthesis and Kinetic, Crystallographic, Computational, and Intraocular Pressure Lowering Investigations.

C. Supuran, E. Masini, M. Ferraroni, 2016, Journal of medicinal chemistry.

Muscarinic antagonists with multiple stereocenters: Synthesis, affinity profile and functional activity of isomeric 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine sulfoxide derivatives.

G. Marucci, M. Buccioni, M. Ferraroni, 2008, Bioorganic & medicinal chemistry.

4-Arylbenzenesulfonamides as Human Carbonic Anhydrase Inhibitors (hCAIs): Synthesis by Pd Nanocatalyst-Mediated Suzuki-Miyaura Reaction, Enzyme Inhibition, and X-ray Crystallographic Studies.

C. Supuran, M. Ferraroni, G. Rance, 2016, Journal of medicinal chemistry.

Structural insights on carbonic anhydrase inhibitory action, isoform selectivity, and potency of sulfonamides and coumarins incorporating arylsulfonylureido groups.

C. Supuran, A. Scozzafava, E. Masini, 2014, Journal of medicinal chemistry.

Combining the tail and the ring approaches for obtaining potent and isoform-selective carbonic anhydrase inhibitors: solution and X-ray crystallographic studies.

C. Supuran, A. Scozzafava, M. Ferraroni, 2014, Bioorganic & medicinal chemistry.

X-ray structural study of Human Neutrophil Elastase inhibition with a series of azaindoles, azaindazoles and isoxazolones

M. Ferraroni, M. Giovannoni, L. Crocetti, 2022, Journal of Molecular Structure.

Diphenylcyclohexylamine derivatives as new potent multidrug resistance (MDR) modulators.

M. Ferraroni, R. Budriesi, A. Chiarini, 2005, Bioorganic & medicinal chemistry.

Dioxygen, an unexpected carbonic anhydrase ligand

A. Cavalli, C. Supuran, A. Scozzafava, 2018, Journal of enzyme inhibition and medicinal chemistry.

Fluorescent sulfonamide carbonic anhydrase inhibitors incorporating 1,2,3-triazole moieties: Kinetic and X-ray crystallographic studies.

C. Supuran, A. Scozzafava, M. Ferraroni, 2016, Bioorganic & medicinal chemistry.

Thioxocoumarins Show an Alternative Carbonic Anhydrase Inhibition Mechanism Compared to Coumarins.

C. Supuran, A. Scozzafava, M. Ferraroni, 2016, Journal of medicinal chemistry.

Determinants for Tight and Selective Binding of a Medicinal Dicarbene Gold(I) Complex to a Telomeric DNA G-Quadruplex: a Joint ESI MS and XRD Investigation.

A. Casini, M. Ferraroni, L. Massai, 2016, Angewandte Chemie.

Structure and function of Aspergillus niger laccase McoG

M. Ferraroni, W. Berkel, A. Westphal, 2017 .

Structure and function of Aspergillus niger laccase

M. Ferraroni, W. Berkel, A. Westphal, 2017 .

Direct and straightforward access to substituted alkyl selenols as novel carbonic anhydrase inhibitors.

C. Supuran, M. Ferraroni, A. Angeli, 2019, European journal of medicinal chemistry.

Synthesis of different thio-scaffolds bearing sulfonamide with subnanomolar carbonic anhydrase II and IX inhibitory properties and X-ray investigations for their inhibitory mechanism.

F. Turco, C. Supuran, M. Ferraroni, 2018, Bioorganic chemistry.

X-Ray diffraction analyses of the natural isoquinoline alkaloids Berberine and Sanguinarine complexed with double helix DNA d(CGTACG).

M. Ferraroni, A. Bilia, P. Gratteri, 2011, Chemical communications.

The crystal structure of human telomeric DNA complexed with berberine: an interesting case of stacked ligand to G-tetrad ratio higher than 1:1

Paola Gratteri, Anna Rita Bilia, Carla Bazzicalupi, 2012, Nucleic acids research.

Preliminary crystallographic analysis of 3-chlorocatechol 1,2-dioxygenase of a new modified ortho-pathway from the Gram-positive Rhodococcus opacus 1CP grown on 2-chlorophenol.

A. Scozzafava, M. Ferraroni, I. Solyanikova, 2003, Acta crystallographica. Section D, Biological crystallography.

Experimental and theoretical affinity studies of substituted phenols to chlorocatechol 1,2-dioxygenases: A step toward the comprehension of inhibitor/substrate binding to intradiol dioxygenases

A. Scozzafava, M. Ferraroni, F. Briganti, 2010 .

Catechol 1,2-dioxygenase from the Gram-positive Rhodococcus opacus 1CP: quantitative structure/activity relationship and the crystal structures of native enzyme and catechols adducts.

A. Scozzafava, M. Ferraroni, L. Golovleva, 2010, Journal of structural biology.

Crystal Structure of the Hydroxyquinol 1,2-Dioxygenase from Nocardioides simplex 3E, a Key Enzyme Involved in Polychlorinated Aromatics Biodegradation*

A. Scozzafava, M. Ferraroni, L. Golovleva, 2005, Journal of Biological Chemistry.

Interaction of a gold(i) dicarbene anticancer drug with human telomeric DNA G-quadruplex: solution and computationally aided X-ray diffraction analysis.

M. Ferraroni, L. Messori, G. Pescitelli, 2018, Dalton transactions.

Synthesis of Azasugar–Sulfonamide conjugates and their Evaluation as Inhibitors of Carbonic Anhydrases: the Azasugar Approach to Selectivity

C. Supuran, M. Ferraroni, A. Angeli, 2021 .

Azidothymidine “Clicked” into 1,2,3-Triazoles: First Report on Carbonic Anhydrase–Telomerase Dual-Hybrid Inhibitors

S. Carradori, C. Supuran, T. Peat, 2020, Journal of medicinal chemistry.

Crystal structures of salicylate 1,2-dioxygenase-substrates adducts: A step towards the comprehension of the structural basis for substrate selection in class III ring cleaving dioxygenases.

A. Scozzafava, M. Ferraroni, A. Stolz, 2012, Journal of structural biology.

One-Pot Procedure for the Synthesis of Asymmetric Substituted Ureido Benzene Sulfonamides as Effective Inhibitors of Carbonic Anhydrase Enzymes.

C. Supuran, E. Masini, M. Ferraroni, 2021, Journal of medicinal chemistry.

Crystal structure and chemical inhibition of essential schistosome host-interactive virulence factor carbonic anhydrase SmCA

C. Supuran, M. Ferraroni, A. Angeli, 2019, Communications Biology.

Development of Praziquantel sulphonamide derivatives as antischistosomal drugs

J. Keiser, C. Supuran, M. Ferraroni, 2022, Journal of enzyme inhibition and medicinal chemistry.

Inhibition of Schistosoma mansoni carbonic anhydrase by the antiparasitic drug clorsulon: X-ray crystallographic and in vitro studies

S. Carradori, C. Supuran, M. Ferraroni, 2022, Acta crystallographica. Section D, Structural biology.

Structural Insights into Schistosoma mansoni Carbonic Anhydrase (SmCA) Inhibition by Selenoureido-Substituted Benzenesulfonamides.

C. Supuran, M. Ferraroni, M. Pinteala, 2021, Journal of medicinal chemistry.

1,3-Oxazole-based selective picomolar inhibitors of cytosolic human carbonic anhydrase II alleviate ocular hypertension in rabbits: Potency is supported by X-ray crystallography of two leads.

C. Supuran, A. Scozzafava, E. Masini, 2017, Bioorganic & medicinal chemistry.

Crystal structure and kinetic studies of a tetrameric type II β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.

C. Supuran, M. Ferraroni, D. Vullo, 2015, Acta crystallographica. Section D, Biological crystallography.

Sulfonamide inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.

C. Supuran, M. Ferraroni, D. Vullo, 2016, Bioorganic & medicinal chemistry.

First-in-Class Dual Hybrid Carbonic Anhydrase Inhibitors and Transient Receptor Potential Vanilloid 1 Agonists Revert Oxaliplatin-Induced Neuropathy

C. Supuran, M. Ferraroni, C. Ghelardini, 2023, Journal of medicinal chemistry.

Diversely substituted sulfamides for fragment-based drug discovery of carbonic anhydrase inhibitors: synthesis and inhibitory profile

C. Supuran, M. Ferraroni, A. Angeli, 2022, Journal of enzyme inhibition and medicinal chemistry.

Carbonic anhydrase inhibitors based on sorafenib scaffold: Design, synthesis, crystallographic investigation and effects on primary breast cancer cells.

Abdul-Malek S. Al-Tamimi, C. Supuran, M. Ferraroni, 2019, European journal of medicinal chemistry.

Sulfonamide carbonic anhydrase inhibitors: Zinc coordination and tail effects influence inhibitory efficacy and selectivity for different isoforms

C. Supuran, A. Scozzafava, M. Ferraroni, 2018 .

Chalcogenides-incorporating carbonic anhydrase inhibitors concomitantly reverted oxaliplatin-induced neuropathy and enhanced antiproliferative action.

S. Carradori, C. Supuran, M. Ferraroni, 2021, European journal of medicinal chemistry.

Discovery of 4-Hydroxy-3-(3-(phenylureido)benzenesulfonamides as SLC-0111 Analogues for the Treatment of Hypoxic Tumors Overexpressing Carbonic Anhydrase IX.

C. Supuran, S. Dedhar, M. Ferraroni, 2018, Journal of medicinal chemistry.

Solution and Solid-State Analysis of Binding of 13-Substituted Berberine Analogues to Human Telomeric G-quadruplexes.

M. Ferraroni, A. Scovassi, P. Lombardi, 2016, Chemistry, an Asian journal.

Mechanisms of the Antiproliferative and Antitumor Activity of Novel Telomerase-Carbonic Anhydrase Dual-Hybrid Inhibitors.

C. Supuran, M. Ferraroni, A. Veselovsky, 2021, Journal of medicinal chemistry.

γ-Carbonic anhydrases

M. Ferraroni, 2019, Carbonic Anhydrases.

Crystal structure of a zinc-activated variant of human carbonic anhydrase I, CA I Michigan 1: evidence for a second zinc binding site involving arginine coordination.

Andrea Scozzafava, Claudiu T Supuran, C. Supuran, 2002, Biochemistry.

Discovery of new 2, 5-disubstituted 1,3-selenazoles as selective human carbonic anhydrase IX inhibitors with potent anti-tumor activity.

C. Supuran, M. Ferraroni, C. Ghelardini, 2018, European journal of medicinal chemistry.

Gentisate 1,2-dioxygenase from the gram-positive bacteria Rhodococcus opacus 1CP: Identical active sites vs. different substrate selectivities.

O. V. Moiseeva, M. Ferraroni, M. Kolomytseva, 2020, Biochimie.

The generation of a 1-hydroxy-2-naphthoate 1,2-dioxygenase by single point mutations of salicylate 1,2-dioxygenase--rational design of mutants and the crystal structures of the A85H and W104Y variants.

A. Scozzafava, M. Ferraroni, A. Stolz, 2012, Journal of structural biology.

Selenols: a new class of carbonic anhydrase inhibitors.

C. Supuran, M. Ferraroni, A. Angeli, 2019, Chemical communications.

The crystal structure of the monomeric human SOD mutant F50E/G51E/E133Q at atomic resolution. The enzyme mechanism revisited.

M. Ferraroni, I. Bertini, K. Wilson, 1999, Journal of molecular biology.

The salicylate 1,2‐dioxygenase as a model for a conventional gentisate 1,2‐dioxygenase: crystal structures of the G106A mutant and its adducts with gentisate and salicylate

A. Scozzafava, M. Ferraroni, A. Stolz, 2013, The FEBS journal.

The crystal structures of native hydroquinone 1,2-dioxygenase from Sphingomonas sp. TTNP3 and of substrate and inhibitor complexes.

A. Scozzafava, M. Ferraroni, B. Kolvenbach, 2017, Biochimica et biophysica acta. Proteins and proteomics.

Salicylate 1,2-dioxygenase from Pseudaminobacter salicylatoxidans: crystal structure of a peculiar ring-cleaving dioxygenase.

A. Scozzafava, M. Ferraroni, A. Stolz, 2008, Journal of molecular biology.

Polypharmacology of Epacadostat: a Potent and Selective Inhibitor of the Tumor Associated Carbonic Anhydrases IX and XII

C. Supuran, M. Ferraroni, A. Angeli, 2019 .

Crystallographic determination of reduced bovine superoxide dismutase at pH 5.0 and of anion binding to its active site

Bruno Bruni, M. Ferraroni, S. Mangani, 1998, JBIC Journal of Biological Inorganic Chemistry.

Selenocarbamates As a Prodrug‐Based Approach to Carbonic Anhydrase Inhibition

C. Supuran, M. Ferraroni, A. Angeli, 2022, ChemMedChem.

Reaction intermediates and redox state changes in a blue laccase from Steccherinum ochraceum observed by crystallographic high/low X-ray dose experiments.

A. Scozzafava, M. Ferraroni, L. Golovleva, 2012, Journal of inorganic biochemistry.

X-ray structures of 4-chlorocatechol 1,2-dioxygenase adducts with substituted catechols: new perspectives in the molecular basis of intradiol ring cleaving dioxygenases specificity.

A. Scozzafava, M. Ferraroni, L. Golovleva, 2013, Journal of structural biology.

Famotidine, an Antiulcer Agent, Strongly Inhibits Helicobacter pylori and Human Carbonic Anhydrases.

C. Supuran, M. Ferraroni, A. Angeli, 2018, ACS medicinal chemistry letters.

Crystal structure of 3-chlorocatechol 1,2-dioxygenase key enzyme of a new modified ortho-pathway from the Gram-positive Rhodococcus opacus 1CP grown on 2-chlorophenol.

A. Scozzafava, M. Ferraroni, I. Solyanikova, 2006, Journal of molecular biology.

Role of the Benzodioxole Group in the Interactions between the Natural Alkaloids Chelerythrine and Coptisine and the Human Telomeric G-Quadruplex DNA. A Multiapproach Investigation.

M. Ferraroni, C. Sissi, P. Gratteri, 2017, Journal of natural products.

Structural basis for the substrate specificity and the absence of dehalogenation activity in 2-chloromuconate cycloisomerase from Rhodococcus opacus 1CP.

A. Scozzafava, M. Ferraroni, L. Golovleva, 2014, Biochimica et biophysica acta.

X-ray crystallographic and molecular docking studies on a unique chloromuconolactone dehalogenase from Rhodococcus opacus 1CP.

A. Scozzafava, M. Ferraroni, L. Golovleva, 2013, Journal of structural biology.

Crystal structure and chemical inhibition of essential schistosome host-interactive virulence factor carbonic anhydrase SmCA

C. Supuran, M. Ferraroni, A. Angeli, 2019, Communications Biology.

Selenolesterase enzyme activity of carbonic anhydrases.

C. Supuran, M. Ferraroni, A. Angeli, 2020, Chemical communications.

Selenols: a new class of Carbonic Anhydrase inhibitors

C. Supuran, M. Ferraroni, A. Angeli, 2018 .

Crystal structure of a blue laccase from Lentinus tigrinus: evidences for intermediates in the molecular oxygen reductive splitting by multicopper oxidases

A. Scozzafava, M. Ferraroni, L. Golovleva, 2007, BMC Structural Biology.

Interaction of a gold(i) dicarbene anticancer drug with human telomeric DNA G-quadruplex: solution and computationally aided X-ray diffraction analysis.

M. Ferraroni, L. Messori, G. Pescitelli, 2018, Dalton transactions.

Laccase isoforms with unusual properties from the basidiomycete Steccherinum ochraceum strain 1833

A. Scozzafava, M. Ferraroni, N. Myasoedova, 2008, Journal of applied microbiology.

Determinants for Tight and Selective Binding of a Medicinal Dicarbene Gold(I) Complex to a Telomeric DNA G-Quadruplex: a Joint ESI MS and XRD Investigation.

A. Casini, M. Ferraroni, L. Massai, 2016, Angewandte Chemie.

C. Supuran, E. Masini, M. Ferraroni, 2018, European journal of medicinal chemistry.

Novel Carbonic Anhydrase Inhibitors with Dual-Tail Core Sulfonamide Show Potent and Lasting Effects for Glaucoma Therapy.

C. Supuran, M. Ferraroni, C. Capasso, 2024, Journal of medicinal chemistry.

Mono- and three-tailed sugar and iminosugar decorated benzenesulfonamide carbonic anhydrase inhibitors.

C. Supuran, M. Ferraroni, A. Angeli, 2023, Organic & biomolecular chemistry.

A new framework for novel analogues of pazopanib as potent and selective human carbonic anhydrase inhibitors: Design, repurposing rational, synthesis, crystallographic, in vivo and in vitro biological assessments.

C. Supuran, M. Ferraroni, A. Angeli, 2024, European journal of medicinal chemistry.

Correction to "Pyridine Derivative of the Natural Alkaloid Berberine as Human Telomeric G4-DNA Binder: A Solution and Solid-State Study".

M. Ferraroni, P. Lombardi, P. Gratteri, 2020, ACS medicinal chemistry letters.

Crystal structure and kinetic studies of a tetrameric type II β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.

C. Supuran, M. Ferraroni, D. Vullo, 2015, Acta crystallographica. Section D, Biological crystallography.

The crystal structures of native hydroquinone 1,2-dioxygenase from Sphingomonas sp. TTNP3 and of substrate and inhibitor complexes.

A. Scozzafava, M. Ferraroni, B. Kolvenbach, 2017, Biochimica et biophysica acta. Proteins and proteomics.

Crystal structure of the monocupin ring-cleaving dioxygenase 5-nitrosalicylate 1,2-dioxygenase from Bradyrhizobium sp.

M. Ferraroni, A. Stolz, E. Eppinger, 2023, Acta crystallographica. Section D, Structural biology.