P. Couvreur

发表

Temperature-dependent rheological behavior of pluronic F-127 aqueous solutions

V. Lenaerts, Caroline Triqueneaux, M. Quartern, 1987 .

Polymer nanocarriers for the delivery of small fragments of nucleic acids: oligonucleotides and siRNA.

C Malvy, P Couvreur, P. Couvreur, 2009, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Nanocarriers’ entry into the cell: relevance to drug delivery

P. Couvreur, H. Hillaireau, 2009, Cellular and Molecular Life Sciences.

Nanotechnology: Intelligent Design to Treat Complex Disease

P. Couvreur, C. Vauthier, 2006, Pharmaceutical Research.

New Bicompartmental Structures Are Observed When Stearylamine is Mixed with Triglyceride Emulsions

J. Lepault, P. Couvreur, S. Benita, 2000, Pharmaceutical Research.

Stimuli-responsive nanocarriers for drug delivery.

Patrick Couvreur, Simona Mura, Julien Nicolas, 2013, Nature materials.

Nanoparticles in cancer therapy and diagnosis.

P. Couvreur, C. Dubernet, I. Brigger, 2002, Advanced drug delivery reviews.

Intraocular injection of tamoxifen‐loaded nanoparticles: a new treatment of experimental autoimmune uveoretinitis

P. Couvreur, M. Naud, C. Klein, 2004, European journal of immunology.

Polycyanoacrylate nanocapsules as potential lysosomotropic carriers: preparation, morphological and sorptive properties

P. Couvreur, P. Speiser, B. Kante, 1979, The Journal of pharmacy and pharmacology.

Disposition kinetics and oral bioavailability of vincamine-loaded polyalkyl cyanoacrylate nanoparticles.

P. Couvreur, P. Maincent, R. Le Verge, 1986, Journal of pharmaceutical sciences.

Attachment of antibiotics to nanoparticles: preparation, drug-release and antimicrobial activity in vitro

P. Couvreur, M. Alonso, A. Andremont, 1987 .

Development of sterically stabilized poly(isobutyl 2-cyanoacrylate) nanoparticles by chemical coupling of poly(ethylene glycol).

P. Couvreur, C. Vauthier, M. Peracchia, 1997, Journal of biomedical materials research.

Stealth® PEGylated polycyanoacrylate nanoparticles for intravenous administration and splenic targeting

P. Couvreur, E. Fattal, M. Besnard, 1999 .

Poly(ethylene glycol)-Coated Hexadecylcyanoacrylate Nanospheres Display a Combined Effect for Brain Tumor Targeting

G. Vassal, P. Couvreur, I. Brigger, 2002, Journal of Pharmacology and Experimental Therapeutics.

Negative preclinical results with stealth nanospheres-encapsulated Doxorubicin in an orthotopic murine brain tumor model.

G. Vassal, P. Couvreur, M. Appel, 2004, Journal of controlled release : official journal of the Controlled Release Society.

Folate-conjugated iron oxide nanoparticles for solid tumor targeting as potential specific magnetic hyperthermia mediators: synthesis, physicochemical characterization, and in vitro experiments.

D. Jaillard, P. Couvreur, P. Colombo, 2005, Bioconjugate chemistry.

Nanoparticles in drug delivery: past, present and future.

P. Couvreur, 2013, Advanced drug delivery reviews.

Colloidal carriers and blood-brain barrier (BBB) translocation: a way to deliver drugs to the brain?

P. Couvreur, K. Andrieux, E. García-García, 2005, International journal of pharmaceutics.

Targeted delivery of antibiotics using liposomes and nanoparticles: research and applications.

P. Couvreur, A. Andremont, H. Pinto-Alphandary, 2000, International journal of antimicrobial agents.

Translocation of poly(ethylene glycol-co-hexadecyl)cyanoacrylate nanoparticles into rat brain endothelial cells: role of apolipoproteins in receptor-mediated endocytosis.

Patrick Couvreur, Myriam Taverna, P. Couvreur, 2007, Biomacromolecules.

Cationic Vectors in Ocular Drug Delivery

P. Couvreur, C. Dubernet, L. Rabinovich‐Guilatt, 2004, Journal of drug targeting.

Metal-organic frameworks in biomedicine.

Gérard Férey, Ruxandra Gref, Patrick Couvreur, 2012, Chemical reviews.

Magnetic nanoparticles: design and characterization, toxicity and biocompatibility, pharmaceutical and biomedical applications.

Patrick Couvreur, Julien Nicolas, P. Couvreur, 2012, Chemical reviews.

A relevant in vitro rat model for the evaluation of blood-brain barrier translocation of nanoparticles

P. Couvreur, V. Nicolas, D. Georgin, 2005, Cellular and Molecular Life Sciences.

Analysis of plasma protein adsorption onto PEGylated nanoparticles by complementary methods: 2‐DE, CE and Protein Lab‐on‐chip® system

P. Couvreur, M. Appel, D. Georgin, 2007, Electrophoresis.

Low-density lipoprotein receptor-mediated endocytosis of PEGylated nanoparticles in rat brain endothelial cells

P. Couvreur, V. Nicolas, M. Appel, 2007, Cellular and Molecular Life Sciences.

Colloidal Carriers: A Promising Way to Treat Central Nervous System Diseases

P. Couvreur, K. Andrieux, E. García-García, 2009 .

Puromycin‐based purification of rat brain capillary endothelial cell cultures. Effect on the expression of blood–brain barrier‐specific properties

P Couvreur, M Debray, P. Couvreur, 2005, Journal of neurochemistry.

Design, functionalization strategies and biomedical applications of targeted biodegradable/biocompatible polymer-based nanocarriers for drug delivery.

Patrick Couvreur, Simona Mura, Julien Nicolas, 2013, Chemical Society reviews.

Porous metal-organic-framework nanoscale carriers as a potential platform for drug delivery and imaging.

Gérard Férey, Ruxandra Gref, Pascal Clayette, 2010, Nature materials.

Oral tolerance elicited in mice by beta-lactoglobulin entrapped in biodegradable microspheres.

A. Pfeifer, P. Couvreur, E. Fattal, 2000, Vaccine.

[Oral tolerance induced by poly (lactide-co-glycolide) containing B lactoglobulin].

P. Couvreur, E. Fattal, S. Pecquet, 2002, Annales pharmaceutiques francaises.

Translation of nanomedicines from lab to industrial scale synthesis: The case of squalene-adenosine nanoparticles.

P. Couvreur, F. Testard, D. Desmaële, 2019, Journal of controlled release : official journal of the Controlled Release Society.

Small-Angle X-ray Scattering Investigations of Biomolecular Confinement, Loading, and Release from Liquid-Crystalline Nanochannel Assemblies.

S. Lesieur, P. Couvreur, A. Angelova, 2012, The journal of physical chemistry letters.

When drug nanocarriers miss their target: extracellular diffusion and cell uptake are not enough to be effective.

P. Couvreur, C. Serre, S. Mura, 2021, Biomaterials Science.

Design attributes of long-circulating polymeric drug delivery vehicles.

Patrick Couvreur, Moritz Beck-Broichsitter, Julien Nicolas, 2015, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Elongated self-assembled nanocarriers: from molecular organization to therapeutic applications.

P. Couvreur, J. Mougin, C. Bourgaux, 2021, Advanced drug delivery reviews.

Evaluation of brain-targeted chitosan nanoparticles through blood–brain barrier cerebral microvessel endothelial cells

P. Couvreur, G. Esendagli, A. Şahin, 2017, Journal of microencapsulation.

Simple Synthesis of Cladribine-Based Anticancer Polymer Prodrug Nanoparticles with Tunable Drug Delivery Properties

P. Couvreur, Yinyin Bao, S. Mura, 2016 .

Self-assembly of polyisoprenoyl gemcitabine conjugates: influence of supramolecular organization on their biological activity.

P. Couvreur, F. Meneau, A. Maksimenko, 2014, Langmuir : the ACS journal of surfaces and colloids.

Interaction of self-assembled squalenoyl gemcitabine nanoparticles with phospholipid-cholesterol monolayers mimicking a biomembrane.

P. Couvreur, B. Stella, V. Rosilio, 2011, Langmuir : the ACS journal of surfaces and colloids.

Combined antitumoral therapy with nanoassemblies of bolaform polyisoprenoyl paclitaxel/gemcitabine prodrugs

P. Couvreur, A. Maksimenko, J. Mougin, 2014 .

Sorptive properties of antibodies onto cyanoacrylic nanoparticles

P. Couvreur, C. Kubiak, L. Manil, 1988 .

New Approach for Oral Administration of Insulin With Polyalkylcyanoacrylate Nanocapsules as Drug Carrier

P. Couvreur, M. Aprahamian, C. Damgé, 1988, Diabetes.

Polyalkylcyanoacrylates as colloidal drug carriers.

P. Couvreur, 1988, Critical reviews in therapeutic drug carrier systems.

Design of nanoparticles of less than 50 nm diameter: preparation, characterization and drug loading

P. Couvreur, E. Fattal, B. Seijo, 1990 .

Nanoparticles as carriers for growth hormone releasing factor

P. Couvreur, J. Grangier, J. Gautier, 1991 .

Controlled drug delivery with nanoparticles : current possibilities and future trends

Patrick Couvreur, Catherine Dubernet, P. Couvreur, 1995 .

Reversion of multidrug resistance using nanoparticles in vitro: Influence of the nature of the polymer

P. Couvreur, M. Poupon, H. Fessi, 1996 .

Polyisobutylcyanoacrylate Nanocapsules Containing an Aqueous Core as a Novel Colloidal Carrier for the Delivery of Oligonucleotides

Elias Fattal, Patrick Couvreur, P. Couvreur, 2000, Pharmaceutical Research.

Preparation and in vitro evaluation of chitosan nanoparticles containing a caspase inhibitor.

P. Couvreur, M. Alonso, Y. Capan, 2005, International journal of pharmaceutics.

Influence of polysaccharide coating on the interactions of nanoparticles with biological systems.

R. Müller, P. Couvreur, C. Passirani, 2006, Biomaterials.

Nanoparticles against Alzheimer's disease: PEG-PACA nanoparticles are able to link the aβ-peptide and influence its aggregation kinetic.

W. Scheper, M. Gobbi, P. Couvreur, 2010, Journal of controlled release : official journal of the Controlled Release Society.

New method based on capillary electrophoresis with laser-induced fluorescence detection (CE-LIF) to monitor interaction between nanoparticles and the amyloid-β peptide.

W. Scheper, M. Gobbi, P. Couvreur, 2010, Analytical chemistry.

Nanotechnologies for Alzheimer's disease: diagnosis, therapy, and safety issues.

Patrick Couvreur, S Moein Moghimi, Julien Nicolas, 2011, Nanomedicine : nanotechnology, biology, and medicine.

Intracarotidal administration of liposomally-entrapped ATP: improved efficiency against experimental brain ischemia.

P. Couvreur, E. Fattal, J. Delattre, 1988, Pharmacological research communications.

Nanomedicines: A New Approach for the Treatment of Serious Diseases

P. Couvreur, C. Vauthier, 2007 .

Synthesis and Cytotoxic Activity of Self‐Assembling Squalene Conjugates of 3‐[(Pyrrol‐2‐yl)methylidene]‐2,3‐dihydro‐1H‐indol‐2‐one Anticancer Agents

P. Couvreur, S. Mura, J. Mougin, 2015 .

Nanoparticles with in vivo anticancer activity from polymer prodrug amphiphiles prepared by living radical polymerization.

P. Couvreur, A. Maksimenko, J. Nicolas, 2013, Angewandte Chemie.

Self-assembled squalenoylated penicillin bioconjugates: an original approach for the treatment of intracellular infections.

P. Couvreur, J. Poupaert, V. Nicolas, 2012, ACS nano.

PEGylated Polymer‐Based Nanoparticles for Drug Delivery to the Brain

P. Couvreur, K. Andrieux, H. Kim, 2011 .

Complement consumption by poly(ethylene glycol) in different conformations chemically coupled to poly(isobutyl 2-cyanoacrylate) nanoparticles.

P Couvreur, P. Couvreur, C. Passirani, 1997, Life sciences.

Visualization of in vitro protein-rejecting properties of PEGylated stealth polycyanoacrylate nanoparticles.

P Couvreur, R. Müller, P. Couvreur, 1999, Biomaterials.

Tissue Distribution of [actinomycin-h-3 D Adsorbed On Polybutylcyanoacrylate Nanoparticles

V. Lenaerts, P. Couvreur, P. Baudhuin, 1980 .

Actinomycin D absorbed on polymethylcyanoacrylate nanoparticles: increased efficiency against an experimental tumor.

P. Couvreur, F. Brasseur, P. Speiser, 1980, European journal of cancer.

Uptake of Nanoparticles by Rat Glomerular Mesangial Cells in Vivo and in Vitro

P. Couvreur, C. Kubiak, L. Manil, 1994, Pharmaceutical Research.

Towards improved HIV-microbicide activity through the co-encapsulation of NRTI drugs in biocompatible metal organic framework nanocarriers.

P. Couvreur, C. Serre, P. Horcajada, 2017, Journal of materials chemistry. B.

Long-Circulating PEGylated Polycyanoacrylate Nanoparticles as New Drug Carrier for Brain Delivery

P. Couvreur, E. Fattal, D. Georgin, 2001, Pharmaceutical Research.

Novel Polysaccharide-Decorated Poly(Isobutyl Cyanoacrylate) Nanoparticles

P. Couvreur, C. Vauthier, D. Labarre, 2003, Pharmaceutical Research.

Poly(alkyl cyanoacrylate) nanospheres for oral administration of insulin.

P Couvreur, P. Couvreur, H Vranckx, 1997, Journal of pharmaceutical sciences.

Advanced nanomedicines for the treatment of inflammatory diseases

P. Couvreur, Romain Brusini, M. Varna, 2020, Advanced Drug Delivery Reviews.

Synthesis and physicochemical characterization of new squalenoyl amphiphilic gadolinium complexes as nanoparticle contrast agents.

P. Couvreur, S. Laurent, L. Vander Elst, 2011, Organic & biomolecular chemistry.

Lipid-Based Anticancer Prodrugs

P. Couvreur, L. H. Reddy, 2010 .

Design of triptorelin loaded nanospheres for transdermal iontophoretic administration.

P. Couvreur, P. Colombo, E. Fattal, 2001, International journal of pharmaceutics.

Gemcitabine Lipid Prodrugs: The Key Role of the Lipid Moiety on the Self-Assembly into Nanoparticles.

P. Couvreur, S. Mura, S. Tusseau-Nenez, 2021, Bioconjugate chemistry.

Desmoplastic Reaction in 3D‐Pancreatic Cancer Tissues Suppresses Molecular Permeability

M. Matsusaki, M. Akashi, M. Kano, 2017, Advanced healthcare materials.

Self-assembled multicompartment liquid crystalline lipid carriers for protein, peptide, and nucleic acid drug delivery.

S. Lesieur, P. Couvreur, A. Angelova, 2011, Accounts of chemical research.

Biodegradable polyalkylcyanoacrylate nanoparticles for the delivery of oligonucleotides.

P. Couvreur, C. Malvy, C. Vauthier, 1998, Journal of controlled release : official journal of the Controlled Release Society.

Biodegradable polymeric nanoformulation based on the antiprotozoal canthin-6-one

P. Couvreur, A. Fournet, J. Arias, 2011 .

Atomic pair distribution function (PDF) study of iron oxide nanoparticles in aqueous suspension

M. Port, P. Couvreur, P. Ballirano, 2009 .

Physico-chemical characterization of polysaccharide-coated nanoparticles.

S. Lesieur, P. Couvreur, H. Hommel, 2005, Journal of controlled release : official journal of the Controlled Release Society.

Interfacial rheology as a tool to study the potential of cyclodextrin polymers to stabilize oil–water interfaces

P. Couvreur, J. Grossiord, R. Gref, 2011 .

Efficient Loading and Controlled Release of Benzophenone-3 Entrapped into Self-Assembling Nanogels

P. Couvreur, K. Bouchemal, R. Gref, 2010 .

A comprehensive study on the inclusion mechanism of benzophenone into supramolecular nanoassemblies prepared using two water-soluble associative polymers

P. Couvreur, J. Poupaert, K. Bouchemal, 2009 .

High-relaxivity magnetic resonance imaging (MRI) contrast agent based on supramolecular assembly between a gadolinium chelate, a modified dextran, and poly-beta-cyclodextrin.

P. Couvreur, P. Durand, E. Gianolio, 2008, Chemistry.

Novel self-assembling nanogels: stability and lyophilisation studies.

P. Couvreur, R. Gref, S. Daoud-Mahammed, 2007, International journal of pharmaceutics.

Oral administration of peptides: Study of a glycerolipidic prodrug

P. Couvreur, D. Nisato, F. Puisieux, 1995 .

Synthesis and in Vitro Study of a Diglyceride Prodrug of a Peptide

P. Couvreur, J. Michel, D. Nisato, 1994, Pharmaceutical Research.

Polysaccharides Grafted with Polyesters: Novel Amphiphilic Copolymers for Biomedical Applications

P. Couvreur, R. Gref, J. Rodrigues, 2002 .

Drug-Initiated Synthesis of Heterotelechelic Polymer Prodrug Nanoparticles for in Vivo Imaging and Cancer Cell Targeting.

L. Mancini, P. Couvreur, S. Mura, 2019, Biomacromolecules.

Novel Polyester-Polysaccharide Nanoparticles

P. Couvreur, M. Besnard, R. Gref, 2003, Pharmaceutical Research.

PEGylated polycyanoacrylate nanoparticles as vector for drug delivery in prion diseases

P. Couvreur, D. Dormont, I. Brigger, 2001, Journal of Neuroscience Methods.

Near Infrared with Principal Component Analysis as a Novel Analytical Approach for Nanoparticle Technology

R. Gurny, P. Couvreur, I. Brigger, 2000, Pharmaceutical Research.

Magnetically responsive microspheres for the pulsed delivery of insulin.

P Couvreur, P. Couvreur, J. Benoit, 1988, Life sciences.

Vitamin C–squalene bioconjugate promotes epidermal thickening and collagen production in human skin

P. Couvreur, R. Gref, D. Desmaële, 2020, Scientific Reports.

Novel PEGylated Nanoassemblies Made of Self‐Assembled Squalenoyl Nucleoside Analogues

P. Couvreur, H. Hillaireau, J. Nicolas, 2008 .

First peptide/protein PEGylation with functional polymers designed by nitroxide-mediated polymerization

P. Couvreur, Y. Guillaneuf, J. Nicolas, 2011 .

Comblike Polymethacrylates with Poly(ethylene glycol) Side Chains via Nitroxide-Mediated Controlled Free-Radical Polymerization

P. Couvreur, J. Nicolas, B. Charleux, 2008 .

PLGA nanocapsules improve the delivery of clarithromycin to kill intracellular Staphylococcus aureus and Mycobacterium abscessus.

P. Couvreur, M. Bischoff, R. Müller, 2019, Nanomedicine : nanotechnology, biology, and medicine.

Liposome-entrapped ampicillin in the treatment of experimental murine listeriosis and salmonellosis

P. Couvreur, E. Fattal, A. Andremont, 1991, Antimicrobial Agents and Chemotherapy.

Ampicillin-loaded liposomes and nanoparticles: comparison of drug loading, drug release and in vitro antimicrobial activity.

P. Couvreur, E. Fattal, A. Andremont, 1991, Journal of microencapsulation.

Effect of nanoparticle-bound ampicillin on the survival of Listeria monocytogenes in mouse peritoneal macrophages.

P. Couvreur, F. Forestier, P. Gerrier, 1992, The Journal of antimicrobial chemotherapy.

Intracellular targeting of antibiotics by means of biodegradable nanoparticles

P. Couvreur, E. Fattal, H. Alphandary, 1992 .

Development of a New Drug Carrier Made from Alginate.

P. Couvreur, C. Vauthier, F. Puisieux, 1993 .

The uptake of ampicillin-loaded nanoparticles by murine macrophages infected with Salmonella typhimurium.

P. Couvreur, A. Andremont, H. Pinto-Alphandary, 1994, Journal of Antimicrobial Chemotherapy.

Intracellular distribution of ampicillin in murine macrophages infected with Salmonella typhimurium and treated with (3H)ampicillin-loaded nanoparticles.

P. Couvreur, A. Andremont, H. Pinto-Alphandary, 1996, The Journal of antimicrobial chemotherapy.

Liposomes and Nanoparticles in the Treatment of Intracellular Bacterial Infections

P. Couvreur, E. Fattal, A. Andremont, 1991, Pharmaceutical Research.

Intracellular Visualization of Ampicillin-Loaded Nanoparticles in Peritoneal Macrophages Infected in Vitro with Salmonella typhimurium

P. Couvreur, A. Andremont, F. Puisieux, 2004, Pharmaceutical Research.

Squalenoyl nanomedicines as potential therapeutics.

P. Couvreur, L. Cattel, B. Stella, 2006, Nano letters.

Conjugation of squalene to gemcitabine as unique approach exploiting endogenous lipoproteins for drug delivery

P. Couvreur, A. Klymchenko, S. Yesylevskyy, 2017, Nature Communications.

Circulating Lipoproteins: A Trojan Horse Guiding Squalenoylated Drugs to LDL-Accumulating Cancer Cells.

M. Windbergs, P. Couvreur, S. Mura, 2017, Molecular therapy : the journal of the American Society of Gene Therapy.

Prodrug-based intracellular delivery of anticancer agents.

P. Couvreur, C. Dubernet, L. Bildstein, 2011, Advanced drug delivery reviews.

COVID-19 and drugs: pathophysiology and therapeutic approaches.

P. Couvreur, D. Louvard, 2021, Comptes rendus biologies.

Solvent selection causes remarkable shifts of the "Ouzo region" for poly(lactide-co-glycolide) nanoparticles prepared by nanoprecipitation.

P. Couvreur, M. Beck-Broichsitter, J. Nicolas, 2015, Nanoscale.

Recent trends in the design of anticancer polymer prodrug nanocarriers

P. Couvreur, J. Nicolas, Vianney Delplace, 2014 .

Nanoparticles as microcarriers for anticancer drugs

P. Couvreur, M. Poupon, F. Brasseur, 1990 .

Polyalkylcyanoacrylate nanoparticles as drug carrier: present state and perspectives

P. Couvreur, C. Vauthier, 1991 .

Surface-engineered nanoparticles for multiple ligand coupling.

P. Couvreur, G. Barratt, R. Gref, 2003, Biomaterials.

Radical Emulsion Polymerization of Alkylcyanoacrylates Initiated by the Redox System Dextran-Cerium(IV) under Acidic Aqueous Conditions

P. Couvreur, C. Vauthier, D. Labarre, 2003 .

Enhancing the tolerance of poly(isobutylcyanoacrylate) nanoparticles with a modular surface design.

P. Couvreur, M. Marden, C. Vauthier, 2007, International journal of pharmaceutics.

Squalenoyl Gemcitabine Monophosphate: Synthesis, Characterisation of Nanoassemblies and Biological Evaluation

P. Couvreur, S. Wack, E. Lepeltier, 2011 .

Transmembrane diffusion of gemcitabine by a nanoparticulate squalenoyl prodrug: an original drug delivery pathway.

P. Couvreur, V. Nicolas, C. Dubernet, 2010, Journal of controlled release : official journal of the Controlled Release Society.

Squalene: A natural triterpene for use in disease management and therapy.

P. Couvreur, L. H. Reddy, 2009, Advanced drug delivery reviews.

Squalene based nanocomposites: a new platform for the design of multifunctional pharmaceutical theragnostics.

P. Couvreur, F. Dosio, R. Gref, 2011, ACS nano.

Squalenoyl-gemcitabine/edelfosine nanoassemblies: anticancer activity in pediatric cancer cells and pharmacokinetic profile in mice.

P. Couvreur, S. Mura, M. Blanco-Prieto, 2020, International journal of pharmaceutics.

Changing the pH of the external aqueous phase may modulate protein entrapment and delivery from poly(lactide-co-glycolide) microspheres prepared by a w/o/w solvent evaporation method.

P. Couvreur, E. Fattal, E. Leo, 1998, Journal of microencapsulation.

Polyunsaturated fatty acids (PUFA) and eicosanoids in human health and pathologies.

P. Couvreur, K. Tew, H. Tapiero, 2002, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Comparative cell uptake of propidium iodide associated with liposomes or nanoparticles.

P. Couvreur, M. Adolphe, J. Delattre, 1987, Cellular and molecular biology.

Enhanced cytotoxicity of doxorubicin encapsulated in polyisohexylcyanoacrylate nanospheres against multidrug-resistant tumour cells in culture.

P. Couvreur, J. Robert, S. Bennis, 1994, European journal of cancer.

Experience with doxorubicin-bound polyisohexylcyanoacrylate nanoparticles on murine alveolar echinococcosis of the liver.

P. Couvreur, F. Némati, C. Bories, 1993, International journal for parasitology.

[Nanoparticles of doxorubicin: colloidal vectors in the treatment of hepatic metastases in animals].

P. Couvreur, J. Benoit, N. Chiannilkulchai, 1989, Bulletin du cancer.

Adsorption/desorption of human serum albumin at the surface of poly(lactic acid) nanoparticles prepared by a solvent evaporation process.

P. Couvreur, D. Bazile, G. Spenlehauer, 1993, Journal of biomedical materials research.

Doxorubicin-loaded nanoparticles: increased efficiency in murine hepatic metastases.

P. Couvreur, J. Benoit, N. Chiannilkulchai, 1989, Selective cancer therapeutics.

Trends in the development of oral anticoagulants.

P. Couvreur, R. Gref, D. Borgel, 2015, Therapeutic delivery.

A new nanomedicine of gemcitabine displays enhanced anticancer activity in sensitive and resistant leukemia types.

P. Couvreur, C. Dubernet, P. Marque, 2007, Journal of controlled release : official journal of the Controlled Release Society.

The Design of Nanoparticles Obtained by Solvent Evaporation: A Comprehensive Study

P. Couvreur, C. Vauthier, J. Vacus, 2003 .

Biological characterization of folic acid-conjugated poly(H2NPEGCA-co-HDCA) nanoparticles in cellular models

P. Couvreur, G. Géraud, L. Cattel, 2007, Journal of drug targeting.

Design of folic acid-conjugated nanoparticles for drug targeting.

P. Couvreur, L. Cattel, J. Hoebeke, 2000, Journal of pharmaceutical sciences.

Increase of doxorubicin sensitivity by doxorubicin-loading into nanoparticles for hepatocellular carcinoma cells in vitro and in vivo.

M. Chevallier, P. Couvreur, E. Soma, 2005, Journal of hepatology.

Isobutyl cyanoacrylate nanoparticles as a solid phase for an efficient immunoradiometric assay.

P. Couvreur, L. Roblot-Treupel, L. Manil, 1986, Biomaterials.

Squalene-based nanoparticles for the targeting of atherosclerotic lesions.

P. Couvreur, V. Nicolas, C. Cailleau, 2020, International journal of pharmaceutics.

Squalenoyl gemcitabine nanomedicine overcomes the low efficacy of gemcitabine therapy in pancreatic cancer.

P. Couvreur, A. Hajri, L. H. Reddy, 2011, Nanomedicine : nanotechnology, biology, and medicine.

Significant Tumor Growth Inhibition from Naturally Occurring Lipid-Containing Polymer Prodrug Nanoparticles Obtained by the Drug-Initiated Method

P. Couvreur, A. Maksimenko, J. Nicolas, 2014 .

Nanomedicines and cell-based therapies for embryonal tumors of the nervous system.

P. Couvreur, E. Garbayo, M. Blanco-Prieto, 2022, Journal of controlled release : official journal of the Controlled Release Society.

Micro- and Nanocarriers for pain alleviation.

P. Couvreur, S. Lepetre-Mouelhi, Alexandre da Silva, 2022, Advanced drug delivery reviews.

A small variation in average particle size of PLGA nanoparticles prepared by nanoprecipitation leads to considerable change in nanoparticles’ characteristics and efficacy of intracellular delivery

M. Khan, P. Couvreur, G. Esendagli, 2017, Artificial cells, nanomedicine, and biotechnology.

Heterotelechelic polymer prodrug nanoparticles: Adaptability to different drug combinations and influence of the dual functionalization on the cytotoxicity

P. Couvreur, Y. Guillaneuf, S. Mura, 2019, Journal of controlled release : official journal of the Controlled Release Society.

A facile route to heterotelechelic polymer prodrug nanoparticles for imaging, drug delivery and combination therapy

P. Couvreur, Y. Guillaneuf, S. Mura, 2018, Journal of controlled release : official journal of the Controlled Release Society.

pH Sensitive Liposomes as Efficient Carriers for Intracellular Delivery of Oligonucleotides

P. Couvreur, C. Ropert, C. Malvy, 1996 .

Transport Mechanisms of Squalenoyl-Adenosine Nanoparticles Across the Blood–Brain Barrier

P. Couvreur, K. Braeckmans, V. Nicolas, 2015 .

Pharmaceutical Aspects of Oligonucleotides

Villejuif, P. Couvreur, C. Malvy, 2000 .

Stability of orosomucoid-coated polyisobutylcyanoacrylate nanoparticles in the presence of serum

P. Couvreur, C. Vauthier, M. Taverna, 1996 .

Synthesis of poly(alkyl cyanoacrylate)-based colloidal nanomedicines.

P. Couvreur, J. Nicolas, 2009, Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology.

Preparation and characterization of biodegradable poly(isobutylcyano acrylate) nanoparticles with the surface modified by the adsorption of proteins

P. Couvreur, C. Vauthier, M. Taverna, 1995 .

Encapsulation of gemcitabine lipophilic derivatives into polycyanoacrylate nanospheres and nanocapsules.

P. Couvreur, L. Cattel, S. Arpicco, 2007, International journal of pharmaceutics.

Preparation and Characterization of Biocompatible Chitosan Nanoparticles for Targeted Brain Delivery of Peptides.

P. Couvreur, T. Dalkara, Y. Capan, 2018, Methods in molecular biology.

Slow Delivery of the Selective Cholecystokinin Agonist pBC 264 into the Rat Nucleus Accumbens Using Microspheres

P. Couvreur, B. Roques, E. Fattal, 1996, Journal of neurochemistry.

Macromolecular Anticancer Therapeutics

R. Jain, P. Couvreur, L. H. Reddy, 2010 .

Electrophoretic pattern of sera of normal and cancer patients.

P. Couvreur, J. Maisin, I. P. Ochrymowicz, 1972, European journal of cancer.

Antineoplastic busulfan encapsulated in a metal organic framework nanocarrier: first in vivo results.

A. Paci, P. Couvreur, C. Serre, 2016, Journal of materials chemistry. B.

Propidium-iodide-loaded polyalkylcyanoacrylate particles —labelling conditions and loading capacity

P. Couvreur, R. Müller, C. Lherm, 1991 .

Gemcitabine lipid prodrug nanoparticles: switching the lipid moiety and changing the fate in the bloodstream.

P. Couvreur, S. Mura, D. Desmaële, 2021, International journal of pharmaceutics.

Comproportionation versus Disproportionation in the Initiation Step of Cu(0)-Mediated Living Radical Polymerization

P. Couvreur, J. Nicolas, S. Harrisson, 2012 .

Simple and efficient copper metal-mediated synthesis of alkoxyamine initiators

P. Couvreur, J. Nicolas, S. Harrisson, 2011 .

The Effect of Site of Administration in the Gastrointestinal Tract on the Absorption of Insulin from Nanocapsules in Diabetic Rats

P. Couvreur, M. Aprahamian, C. Damgé, 1991, The Journal of pharmacy and pharmacology.

In vivo uptake of polyisobutyl cyanoacrylate nanoparticles by rat liver Kupffer, endothelial, and parenchymal cells.

V. Lenaerts, P. Couvreur, T. V. van Berkel, 1984, Journal of pharmaceutical sciences.

Interactions of anticancer drugs with biomembranes: what can we learn from model membranes?

P. Couvreur, C. Bourgaux, 2014, Journal of controlled release : official journal of the Controlled Release Society.

Therapeutic Aspects of Liposomes

P. Couvreur, G. Barratt, J. Delattre, 1990 .

Influence of Surface Properties on the Inflammatory Response to Polymeric Nanoparticles

J. Féger, P. Couvreur, E. Fattal, 1995, Pharmaceutical Research.

Novel approaches to deliver gemcitabine to cancers.

P. Couvreur, L. H. Reddy, 2008, Current pharmaceutical design.

(Poly-cyanoacrylate) nanomedicines for cancer and beyond: Lessons learned.

P. Couvreur, 2021, Journal of controlled release : official journal of the Controlled Release Society.

Squalenoylation: a generic platform for nanoparticular drug delivery.

P. Couvreur, R. Gref, D. Desmaële, 2012, Journal of controlled release : official journal of the Controlled Release Society.

A Polysorbate-Based Non-Ionic Surfactant Can Modulate Loading and Release of β-Lactoglobulin Entrapped in Multiphase Poly(DL-Lactide-co-glycolide) Microspheres

P. Couvreur, E. Fattal, E. Leo, 1999, Pharmaceutical Research.

Intranasal immunization with protein-linked phosphorylcholine protects mice against a lethal intranasal challenge with streptococcus pneumoniae.

P. Couvreur, B. Diamond, E. Fattal, 2000, Vaccine.

Mucosal immunogenicity elicited in mice by oral vaccination with phosphorylcholine encapsulated in poly (D,L-lactide-co-glycolide) microspheres.

P. Couvreur, E. Fattal, A. Andremont, 1998, Vaccine.

Protective immunity against Salmonella typhimurium elicited in mice by oral vaccination with phosphorylcholine encapsulated in poly(DL-lactide-co-glycolide) microspheres

P. Couvreur, E. Fattal, A. Andremont, 1997, Infection and immunity.

Some parameters influencing cytotoxicity of free doxorubicin and doxorubicin-loaded nanoparticles in sensitive and multidrug resistant leucemic murine cells: incubation time, number of nanoparticles per cell

P. Couvreur, M. Poupon, C. Dubernet, 1994 .

Study of emulsion stabilization by graft copolymers using the optical analyzer Turbiscan.

P. Couvreur, C. Vauthier, R. Gref, 2003, International journal of pharmaceutics.

Analysis of Serum Proteins by Micellar Electrokinetic Capillary Chromatography. Application to a Drug Carrier Evaluation

P. Couvreur, C. Vauthier, M. Taverna, 1996 .

The role of solvent swelling in the self-assembly of squalene based nanomedicines.

P. Couvreur, D. Saha, I. Grillo, 2015, Soft matter.

Gemcitabine-based therapy for pancreatic cancer using the squalenoyl nucleoside monophosphate nanoassemblies.

P. Couvreur, A. Maksimenko, J. Mougin, 2015, International journal of pharmaceutics.

Efficient “green” encapsulation of a highly hydrophilic anticancer drug in metal–organic framework nanoparticles

P. Couvreur, A. Maksimenko, S. Monti, 2015, Journal of drug targeting.

Extracellular-protein-enhanced cellular uptake of squalenoyl gemcitabine from nanoassemblies

P. Couvreur, C. Dubernet, D. Desmaële, 2010 .

Squalenoyl nucleoside monophosphate nanoassemblies: new prodrug strategy for the delivery of nucleotide analogues.

P. Couvreur, S. Wack, D. Desmaële, 2010, Bioorganic & medicinal chemistry letters.

Interaction of a new anticancer prodrug, gemcitabine-squalene, with a model membrane: coupled DSC and XRD study.

P. Couvreur, H. Amenitsch, M. Ollivon, 2010, Biochimica et Biophysica Acta.

Preclinical Toxicology (Subacute and Acute) and Efficacy of a New Squalenoyl Gemcitabine Anticancer Nanomedicine

P. Couvreur, C. Dubernet, D. Desmaële, 2008, Journal of Pharmacology and Experimental Therapeutics.

Freeze-drying of squalenoylated nucleoside analogue nanoparticles.

P. Couvreur, H. Hillaireau, C. Dubernet, 2009, International journal of pharmaceutics.

Nanoencapsulation of antiviral nucleotide analogs

P. Couvreur, H. Hillaireau, 2009 .

Acute Renal Toxicity of Doxorubicin (Adriamycin)-Loaded Cyanoacrylate Nanoparticles

P. Couvreur, L. Manil, P. Mahieu, 2004, Pharmaceutical Research.

On shelf stability of freeze-dried poly(methylidene malonate 2.1.2) nanoparticles

P. Couvreur, F. Lescure, P. Breton, 1997 .

New Poly(Methylidene Malonate 2.1.2) Nanoparticles: Recent Developments

P. Couvreur, F. Lescure, P. Breton, 1994 .

Antiglaucomatous activity of betaxolol chlorhydrate sorbed onto different isobutylcyanoacrylate nanoparticle preparations

P. Couvreur, P. Maincent, J. Spittler, 1990 .

Development of a nanoparticle controlled-release formulation for human use

V. Lenaerts, P. Couvreur, M. Roland, 1986 .

Doxorubicin-loaded nanospheres bypass tumor cell multidrug resistance.

P. Couvreur, M. Poupon, S. Chevillard, 1992, Biochemical pharmacology.

Surface Pressure and Surface Potential Studies of Poly(Isobutylcyanoacrylate)-Ampicillin Interactions at the Water-Air Interface

P. Couvreur, A. Baszkin, M. Deyme, 1989 .

The use of poly (isobutyl cyanoacrylate) nanoparticles with selected antifungal drugs

P. Couvreur, P. Volz, P. S. Bajwa, 1987 .

Quantitative study of the interaction between polybutylcyanoacrylate nanoparticles and mouse peritoneal macrophages in culture.

P. Couvreur, P. Guiot, 1983, Journal de pharmacie de Belgique.

Physicochemical and morphological characterization of polyisobutyl cyanoacrylate nanocapsules.

P. Couvreur, F. Puisieux, L. Roblot-Treupel, 1986, Journal of pharmaceutical sciences.

[Monoclonal-antibodies for the Targeting of Drugs]

P. Couvreur, 1984 .

Squalene-Adenosine Nanoparticles: Ligands of Adenosine Receptors or Adenosine Prodrug?

A. IJzerman, P. Couvreur, J. Mougin, 2019, The Journal of Pharmacology and Experimental Therapeutics.

Structural characterization of ultrasmall superparamagnetic iron oxide (USPIO) particles in aqueous suspension by energy dispersive X-ray diffraction (EDXD).

M. Port, P. Couvreur, P. Ballirano, 2006, Journal of the American Chemical Society.

Uptake of doxorubicin from loaded nanoparticles in multidrug-resistant leukemic murine cells

P. Couvreur, M. Poupon, C. Dubernet, 2004, Cancer Chemotherapy and Pharmacology.

Lipid-Conjugation of Endogenous Neuropeptides: Improved Biotherapy against Human Pancreatic Cancer

P. Couvreur, A. Maksimenko, S. Mura, 2015, Advanced healthcare materials.

Role of gut macrophages in mice orally contaminated with scrapie or BSE.

P. Couvreur, E. Fattal, J. Deslys, 2005, International journal of pharmaceutics.

Involvement of Macrophages in the Pathogenesis of Transmissible Spongiform Encephalopathies

P. Couvreur, D. Dormont, V. Béringue, 2002, Developmental immunology.

Visualization of Insulin-Loaded Nanocapsules: In Vitro and in Vivo Studies After Oral Administration to Rats

D. Jaillard, P. Couvreur, C. Vauthier, 2003, Pharmaceutical Research.

Biodegradable microparticles for the mucosal delivery of antibacterial and dietary antigens.

P. Couvreur, E. Fattal, A. Andremont, 2002, International journal of pharmaceutics.

Effect of polymeric nanoparticle administration on the clearance activity of the mononuclear phagocyte system in mice.

J. Féger, P. Couvreur, P. Bedossa, 1996, Journal of biomedical materials research.

Laboratory techniques in biochemistry and molecular biology: An introduction to radioimmunoassay and related techniques: T. Chard (Ed.), Elsevier, Amsterdam, 1990, 290 pp

P. Couvreur, 1991 .

I. Arginine : Free amino acids in human health and pathologies. Part 1

P. Couvreur, K. Tew, H. Tapiero, 2002 .

Biocompatible poly(methylidene malonate)-made materials for pharmaceutical and biomedical applications.

David Bonnafous, P. Couvreur, E. Fattal, 2008, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Interfacial behavior of PEGylated lipids and their effect on the stability of squalenoyl-drug nanoassemblies.

P. Couvreur, V. Rosilio, R. Gref, 2014, International journal of pharmaceutics.

‘Green’ fluorine-free mesoporous iron(III) trimesate nanoparticles for drug delivery

H. Willaime, P. Couvreur, C. Serre, 2013 .

Quantification of trimesic acid in liver, spleen and urine by high-performance liquid chromatography coupled to a photodiode-array detection.

P. Couvreur, C. Serre, P. Horcajada, 2011, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

GraftFast Surface Engineering to Improve MOF Nanoparticles Furtiveness.

P. Couvreur, C. Serre, Á. González-Fernández, 2018, Small.

Superior preclinical efficacy of gemcitabine developed as chitosan nanoparticulate system.

P. Couvreur, J. Arias, L. H. Reddy, 2011, Biomacromolecules.

Interaction of an amphiphilic squalenoyl prodrug of gemcitabine with cellular membranes.

P. Couvreur, F. Meneau, S. Wack, 2011, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Drug delivery: replenishing reservoirs in vivo.

P. Couvreur, 2014, Nature nanotechnology.

Synthesis of a deuterated probe for the confocal Raman microscopy imaging of squalenoyl nanomedicines

M. Windbergs, P. Couvreur, S. Mura, 2016, Beilstein journal of organic chemistry.

A Smart Metal-Organic Framework Nanomaterial for Lung Targeting.

P. Couvreur, C. Serre, M. Giménez‐Marqués, 2017, Angewandte Chemie.

Biodistribution and anticancer activity of a new vinca alkaloid encapsulated into long-circulating liposomes

P. Couvreur, P. Wüthrich, J. Péan, 2009, Journal of liposome research.

Squalenoyl nanomedicine of gemcitabine is more potent after oral administration in leukemia-bearing rats: study of mechanisms

P. Couvreur, C. Dubernet, L. H. Reddy, 2008, Anti-cancer drugs.

An efficient system for intracellular delivery of beta-lactam antibiotics to overcome bacterial resistance

P. Couvreur, V. Nicolas, J. Mougin, 2015, Scientific Reports.

Squalenoylation Favorably Modifies the in Vivo Pharmacokinetics and Biodistribution of Gemcitabine in Mice

A. Paci, G. Vassal, P. Couvreur, 2008, Drug Metabolism and Disposition.

Compartmentalized Encapsulation of Two Antibiotics in Porous Nanoparticles: an Efficient Strategy to Treat Intracellular Infections

G. Salzano, P. Couvreur, C. Serre, 2019, Particle & Particle Systems Characterization.

Squalene versus cholesterol: Which is the best nanocarrier for the delivery to cells of the anticancer drug gemcitabine?

P. Couvreur, S. Yesylevskyy, C. Ramseyer, 2018, Comptes Rendus Chimie.

Reversion of multidrug resistance with polyalkylcyanoacrylate nanoparticles: towards a mechanism of action.

P. Couvreur, E. Soma, M. Appel, 1997, British Journal of Cancer.

Splenic Trapping of Nanoparticles: Complementary Approaches for In Situ Studies

P. Couvreur, B. Gouritin, J. Andreux, 1997, Pharmaceutical Research.

Towards an Improved anti‐HIV Activity of NRTI via Metal–Organic Frameworks Nanoparticles

H. Willaime, P. Couvreur, C. Serre, 2013, Advanced healthcare materials.

Novel nanoassemblies composed of squalenoyl-paclitaxel derivatives: synthesis, characterization, and biological evaluation.

P. Couvreur, F. Dosio, L. Cattel, 2010, Bioconjugate chemistry.

Phase I clinical trial and pharmacokinetic evaluation of doxorubicin carried by polyisohexylcyanoacrylate nanoparticles

P. Couvreur, P. Rougier, J. Droz, 1992, Investigational New Drugs.

BioMOFs: Metal—Organic Frameworks for Biological and Medical Applications

P. Couvreur, C. Serre, Alistair C. McKinlay, 2011 .

Oil/water “hand-bag like structures”: how interfacial rheology can help to understand their formation?

J. Lepault, P. Couvreur, F. Boury, 2005 .

Therapeutic Modalities of Squalenoyl Nanocomposites in Colon Cancer: An Ongoing Search for Improved Efficacy

P. Couvreur, A. Maksimenko, J. Mougin, 2014, ACS nano.

Breaking photoswitch activation depth limit using ionising radiation stimuli adapted to clinical application

S. Mériaux, P. Couvreur, C. Roulin, 2022, Nature Communications.

The Drug-Initiated Method: A Convenient Approach for the Synthesis of Efficient Polymer Prodrug Nanoparticles.

P. Couvreur, A. Maksimenko, J. Nicolas, 2015 .

Pharmacokinetics and Biodistribution of Oligonucleotide Adsorbed onto Poly(isobutylcyanoacrylate) Nanoparticles After Intravenous Administration in Mice

P. Couvreur, E. Fattal, Y. Nakada, 2004, Pharmaceutical Research.

Comparison of the ocular distribution of a model oligonucleotide after topical instillation in rabbits of conventional and new dosage forms.

P. Couvreur, E. Fattal, A. Bochot, 1998, Journal of drug targeting.

Stacking as a Key Property for Creating Nanoparticles with Tunable Shape: The Case of Squalenoyl-Doxorubicin.

P. Couvreur, F. Dosio, B. Stella, 2019, ACS nano.

key for The case of squalenoyl-doxorubicin

P. Couvreur, F. Dosio, B. Stella, 2022 .

Adsorption of hematoporphyrin onto polyalkylcyanoacrylate nanoparticles: carrier capacity and drug release

P. Couvreur, N. Brasseur, D. Brault, 1991 .

Evaluation of hepatic antioxidant systems after intravenous administration of polymeric nanoparticles.

E Fattal, P Couvreur, J. Féger, 1997, Biomaterials.

From Preparation to Real Applications as Drug Delivery Systems

P. Couvreur, C. Vauthier, C. Dubernet, 2004 .

Evaluation of liver toxicological effects induced by polyalkylcyanoacrylate nanoparticles.

J. Féger, P. Couvreur, E. Fattal, 1995, Toxicology and applied pharmacology.

Selective modification of a native protein in a patient tissue homogenate using palladium nanoparticles.

P. Couvreur, H. Remita, D. Desmaële, 2019, Chemical communications.

Nanotheranostics for personalized medicine.

Patrick Couvreur, Simona Mura, P. Couvreur, 2016, Advanced drug delivery reviews.

siRNA nanoformulation against the Ret/PTC1 junction oncogene is efficient in an in vivo model of papillary thyroid carcinoma

P. Couvreur, M. Santoro, A. Fusco, 2007, Nucleic acids research.

Spleen Capture of Nanoparticles: Influence of Animal Species and Surface Characteristics

P. Couvreur, B. Gouritin, J. Andreux, 2004, Pharmaceutical Research.

New Formulation for the Delivery of Oligonucleotides Using "Clickable" siRNA-Polyisoprenoid-Conjugated Nanoparticles: Application to Cancers Harboring Fusion Oncogenes.

P. Couvreur, S. Arpicco, B. Stella, 2018, Bioconjugate chemistry.

Extensive surface studies help to analyse zeta potential data: the case of cationic emulsions.

P. Couvreur, S. Benita, C. Dubernet, 2004, Chemistry and physics of lipids.

Synthesis, characterization, and in vivo delivery of siRNA-squalene nanoparticles targeting fusion oncogene in papillary thyroid carcinoma.

P. Couvreur, G. Clayman, E. Lepeltier, 2011, Journal of medicinal chemistry.

Improving the Antitumor Activity of Squalenoyl‐Paclitaxel Conjugate Nanoassemblies by Manipulating the Linker between Paclitaxel and Squalene

P. Couvreur, S. Wack, A. Maksimenko, 2013, Advanced healthcare materials.

Establishment of an in vitro model expressing the folate receptor for the investigation of targeted delivery systems

P. Couvreur, P. Colombo, B. Stella, 2005 .

Polyalkylcyanoacrylate nanoparticles as carriers for granulocyte-colony stimulating factor (G-CSF).

P. Couvreur, R. Favier, L. Douay, 1998, Journal of controlled release : official journal of the Controlled Release Society.

Cells involved in the capture of nanoparticles in hematopoietic organs.

P. Couvreur, B. Gouritin, J. Andreux, 1996, Journal of pharmaceutical sciences.

Increased bone marrow toxicity of doxorubicin bound to nanoparticles.

P. Couvreur, J. Andreux, C. Weingarten, 1994, European journal of cancer.

Liposomes Dispersed Within a Thermosensitive Gel: A New Dosage Form for Ocular Delivery of Oligonucleotides

P. Couvreur, E. Fattal, A. Bochot, 1998, Pharmaceutical Research.

Multifunctional squalene-based prodrug nanoparticles for targeted cancer therapy.

P. Couvreur, A. Maksimenko, J. Nicolas, 2014, Chemical communications.

Alkylcyanoacrylate drug carriers. I : Physicochemical characterization of nanoparticles with different alkyl chain length

R. Müller, P. Couvreur, T. Blunk, 1992 .

Lymphatic Targeting of Polymeric Nanoparticles After Intraperitoneal Administration in Rats

P. Couvreur, J. Kreuter, P. Maincent, 1992, Pharmaceutical Research.

Liposomally-entrapped ATP: improved efficiency against experimental brain ischemia in the rat.

P. Couvreur, E. Fattal, J. Delattre, 1987, Life sciences.

Adsorption of Oligonucleotides onto Polyisohexylcyanoacrylate Nanoparticles Protects Them Against Nucleases and Increases Their Cellular Uptake

P. Couvreur, T. Doan, F. Puisieux, 1994, Pharmaceutical Research.

Spongelike alginate nanoparticles as a new potential system for the delivery of antisense oligonucleotides.

P. Couvreur, C. Vauthier, E. Fattal, 1999, Antisense & nucleic acid drug development.

Polyisoprenoyl gemcitabine conjugates self assemble as nanoparticles, useful for cancer therapy.

P. Couvreur, A. Maksimenko, E. Lepeltier, 2013, Cancer letters.

Toxicity of metal-organic framework nanoparticles: from essential analyses to potential applications.

P. Couvreur, C. Serre, S. Wuttke, 2022, Chemical Society reviews.

Squalenoylation of Chitosan: A Platform for Drug Delivery?

P. Couvreur, C. Lehr, B. Loretz, 2015, Biomacromolecules.

Detailed structure of diamond-type lipid cubic nanoparticles.

S. Lesieur, P. Couvreur, A. Angelova, 2006, Journal of the American Chemical Society.

DNA/Fusogenic Lipid Nanocarrier Assembly: Millisecond Structural Dynamics.

S. Lesieur, P. Štěpánek, P. Couvreur, 2013, The journal of physical chemistry letters.

Swelling of a Sponge Lipid Phase via Incorporation of a Nonionic Amphiphile: SANS and SAXS Studies

S. Lesieur, P. Couvreur, S. Funari, 2011 .

In vivo fate and immune pulmonary response after nasal administration of microspheres loaded with phosphorylcholine-thyroglobulin.

P. Couvreur, E. Caudron, E. Fattal, 1999, International journal of pharmaceutics.

Nanomedicine: From where are we coming and where are we going?

P. Couvreur, 2019, Journal of controlled release : official journal of the Controlled Release Society.

Retroviral inhibition by antisense oligonucleotides determined by intracellular stability.

P. Couvreur, C. Ropert, C. Malvy, 1994, Antisense research and development.

New Core-Shell Nanoparticules for the Intravenous Delivery of siRNA to Experimental Thyroid Papillary Carcinoma

P. Couvreur, C. Malvy, J. Bertrand, 2010, Pharmaceutical Research.

Interaction of an anticancer drug, gemcitabine, with phospholipid bilayers

P. Couvreur, F. Meneau, M. Ollivon, 2009 .

Synthesis of poly(alkyl cyanoacrylate)-based colloidal

P. Couvreur, 2009 .

A new generation of polymer nanoparticles for drug delivery.

P. Couvreur, M. Marden, C. Vauthier, 2010, Cellular and molecular biology.

Polymer prodrug nanoparticles based on naturally occurring isoprenoid for anticancer therapy.

P. Couvreur, C. Vauthier, A. Maksimenko, 2013, Biomacromolecules.

Busulphan-loaded long-circulating nanospheres, a very attractive challenge for both galenists and pharmacologists

A. Paci, G. Vassal, P. Couvreur, 2007, Journal of microencapsulation.

Effects of silencing the RET/PTC1 oncogene in papillary thyroid carcinoma by siRNA-squalene nanoparticles with and without fusogenic companion GALA-cholesterol.

P. Couvreur, H. Harashima, A. Maksimenko, 2014, Thyroid : official journal of the American Thyroid Association.

Biodegradable nanoparticles for subcutaneous administration of growth hormone releasing factor (hGRF)

P. Couvreur, P. Dupont, J. Grangier, 1992 .

Intravitreal delivery of oligonucleotides by sterically stabilized liposomes.

P. Couvreur, J. Jeanny, E. Fattal, 2002, Investigative ophthalmology & visual science.

Adenosine and lipids: A forced marriage or a love match?

P. Couvreur, M. Rouquette, S. Lepetre-Mouelhi, 2019, Advanced drug delivery reviews.

Characterization of a new ocular delivery system based on a dispersion of liposomes in a thermosensitive gel

P. Couvreur, E. Fattal, A. Bochot, 1998 .

Nanomedicine as a promising approach for the treatment and diagnosis of brain diseases: the example of Alzheimer's disease.

P. Couvreur, K. Andrieux, 2013, Annales pharmaceutiques francaises.

Formulation of glycerolipidic prodrugs into PEGylated liposomes for brain delivery

P. Couvreur, V. Nicolas, N. Tsapis, 2009 .

Liposomal formulation of a glycerolipidic prodrug for lymphatic delivery of didanosine via oral route.

A. Paci, P. Couvreur, M. Besnard, 2007, International journal of pharmaceutics.

Protein-Functionalized Nanoparticles Derived from End-Functional Polymers and Polymer Prodrugs for Crossing the Blood-Brain Barrier.

M. Masserini, P. Couvreur, F. Re, 2019, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Characterization of oligonucleotide/lipid interactions in submicron cationic emulsions: influence of the cationic lipid structure and the presence of PEG-lipids.

J. Lepault, D. Scherman, P. Couvreur, 2001, Biophysical chemistry.

Factors influencing the oligonucleotides release from O-W submicron cationic emulsions.

D. Scherman, P. Couvreur, S. Benita, 2001, Journal of controlled release : official journal of the Controlled Release Society.

Lipid prodrug nanocarriers in cancer therapy.

P. Couvreur, S. Mura, J. Nicolas, 2015, Journal of controlled release : official journal of the Controlled Release Society.

Reversion of multidrug resistance by co-encapsulation of doxorubicin and cyclosporin A in polyalkylcyanoacrylate nanoparticles.

P Couvreur, P. Couvreur, S. Benita, 2000, Biomaterials.

A Self-Assembling NHC-Pd-Loaded Calixarene as a Potent Catalyst for the Suzuki-Miyaura Cross-Coupling Reaction in Water

P. Couvreur, Ibrahim Abdellah, C. Martini, 2020, Molecules.

Palladium: a future key player in the nanomedical field?

P. Couvreur, A. Dumas, 2015, Chemical science.

Metabolism evaluation of biomimetic prodrugs by in vitro models and mass spectrometry.

A. Paci, G. Vassal, P. Couvreur, 2009, International journal of pharmaceutics.

Hybrid polymer nanocapsules enhance in vitro delivery of azidothymidine-triphosphate to macrophages.

P. Couvreur, H. Hillaireau, M. Appel, 2006, Journal of controlled release : official journal of the Controlled Release Society.

Specific antitumor targetable beta-cyclodextrin-poly(ethylene glycol)-folic acid drug delivery bioconjugate.

Alessandra Semenzato, Patrick Couvreur, Catherine Dubernet, 2004, Bioconjugate chemistry.

Supramolecular organization of S12363-liposomes prepared with two different remote loading processes.

Patrick Couvreur, Georg Pabst, P. Couvreur, 2009, Biochimica et biophysica acta.

A comprehensive study of the spontaneous formation of nanoassemblies in water by a "lock-and-key" interaction between two associative polymers.

P. Couvreur, K. Bouchemal, R. Gref, 2011, Journal of colloid and interface science.

New self-assembled nanogels based on host-guest interactions: characterization and drug loading.

Ruxandra Gref, Brigitte Gillet, Patrick Couvreur, 2006, Journal of controlled release : official journal of the Controlled Release Society.

Cyclodextrins for drug delivery

P Couvreur, P. Couvreur, R. Gref, 2010, Journal of drug targeting.

A method of forming emulsions based on polymers of cyclodextrin and lipophilic compounds, emulsions thus obtained, and compositions comprising said emulsions

P. Couvreur, C. Amiel, R. Gref, 2009 .

II. Glutamine and glutamate.

P. Couvreur, K. Tew, H. Tapiero, 2002, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Nanocapsules as carriers for oral peptide delivery

Patrick Couvreur, Christiane Damgé, P. Couvreur, 1990 .

In vitro model for the degradation of alkylcyanoacrylate nanoparticles.

P. Couvreur, R. Müller, C. Lherm, 1990, Biomaterials.

Abstracts of Dutch doctoral theses

R. A. Zeeuw, G. J. Jong, M. J. M. Zeeland, 2005, Pharmaceutisch Weekblad.

Nanomedicines for Pediatric Cancers.

P. Couvreur, A. Aldaz, M. Blanco-Prieto, 2018, ACS nano.

Rational design for multifunctional non-liposomal lipid-based nanocarriers for cancer management: theory to practice

P. Couvreur, B. Stella, S. Mura, 2013, Journal of Nanobiotechnology.

Self-assembling cyclodextrin based hydrogels for the sustained delivery of hydrophobic drugs.

P Couvreur, P. Couvreur, C. Amiel, 2008, Journal of biomedical materials research. Part A.

Original tamoxifen-loaded gels containing cyclodextrins: in situ self-assembling systems for cancer treatment

P. Couvreur, C. Amiel, M. Besnard, 2004 .

In depth analysis of the in vivo toxicity of nanoparticles of porous iron(III) metal–organic frameworks

Ruxandra Gref, Patrick Couvreur, Christian Serre, 2013 .

Hepatic tissue distribution of doxorubicin-loaded nanoparticles after i.v. administration in reticulosarcoma M 5076 metastasis-bearing mice

P. Couvreur, B. Caillou, J. Devissaguet, 2008, Cancer Chemotherapy and Pharmacology.

Investigation of the role of macrophages on the cytotoxicity of doxorubicin and doxorubicin-loaded nanoparticles on M5076 cells in vitro.

P Couvreur, P. Couvreur, S. Benita, 2000, Journal of controlled release : official journal of the Controlled Release Society.

Molecular Weights of Free and Drug-Loaded Nanoparticles

P. Couvreur, M. Roland, L. Vansnick, 2004, Pharmaceutical Research.

Degradation of poly (isobutyl cyanoacrylate) nanoparticles.

V. Lenaerts, P. Couvreur, P. Speiser, 1984, Biomaterials.

BioMOFs: metal-organic frameworks for biological and medical applications.

Gérard Férey, Ruxandra Gref, Patrick Couvreur, 2010, Angewandte Chemie.

A Squalene-Based Nanomedicine for Oral Treatment of Colon Cancer.

P. Couvreur, J. Mougin, D. Desmaële, 2017, Cancer research.

Development of a new drug carrier made from alginate.

P Couvreur, P. Couvreur, C. Vauthier, 1993, Journal of pharmaceutical sciences.

Drug Targeting by Polyalkylcyanoacrylate Nanoparticles Is Not Efficient Against Persistent Salmonella

P. Couvreur, A. Andremont, E. Chachaty, 1998, Pharmaceutical Research.

Treatment of experimental salmonellosis in mice with ampicillin-bound nanoparticles

P. Couvreur, E. Fattal, A. Andremont, 1989, Antimicrobial Agents and Chemotherapy.

Effectiveness of nanoparticle-bound ampicillin in the treatment of Listeria monocytogenes infection in athymic nude mice

P. Couvreur, E. Fattal, A. Andremont, 1988, Antimicrobial Agents and Chemotherapy.

Intravitreal administration of antisense oligonucleotides: potential of liposomal delivery

Elias Fattal, Patrick Couvreur, Amélie Bochot, 2000, Progress in Retinal and Eye Research.

Role of spleen macrophages in the clearance of scrapie agent early in pathogenesis

Patrick Couvreur, Vincent Beringue, P. Couvreur, 2000, The Journal of pathology.

Nanocarriers for antibiotics: a promising solution to treat intracellular bacterial infections.

P. Couvreur, N. Abed, 2014, International journal of antimicrobial agents.

Drug delivery to resistant tumors: the potential of poly(alkyl cyanoacrylate) nanoparticles.

P Couvreur, P. Couvreur, C. Vauthier, 2003, Journal of controlled release : official journal of the Controlled Release Society.

Squalenyl Hydrogen Sulfate Nanoparticles for Simultaneous Delivery of Tobramycin and an Alkylquinolone Quorum Sensing Inhibitor Enable the Eradication of P. aeruginosa Biofilm Infections

R. Hartmann, P. Couvreur, R. Müller, 2020, Angewandte Chemie.

How can nanomedicines overcome cellular-based anticancer drug resistance?

P. Couvreur, S. Mura, D. Sobot, 2016, Journal of materials chemistry. B.

Paraquat detoxication with multiple emulsions.

P. Couvreur, B. Lacour, J. Grossiord, 2009, International journal of pharmaceutics.

Nanoparticles of Metal‐Organic Frameworks: On the Road to In Vivo Efficacy in Biomedicine

P. Couvreur, C. Serre, Angelika Mielcarek, 2018, Advanced materials.

[Polymer nanoparticles for the delivery of anticancer drug].

P. Couvreur, J. Nicolas, 2017, Medecine sciences : M/S.

[Hybrid nanocarriers for controlled delivery of antitumour and retroviral drugs delivery].

P. Couvreur, C. Serre, P. Horcajada, 2010, Medecine sciences : M/S.

Use of solvent effects to improve control over nitroxide-mediated polymerization of isoprene.

P. Couvreur, J. Nicolas, S. Harrisson, 2012, Macromolecular rapid communications.

SG1 Nitroxide-Mediated Polymerization of Isoprene: Alkoxyamine Structure/Control Relationship and α,ω–Chain-End Functionalization

P. Couvreur, J. Nicolas, S. Harrisson, 2011 .

Design, Functionalization Strategies and Biomedical Applications of Targeted Biodegradable/Biocompatible Polymer‐Based Nanocarriers for Drug Delivery

Patrick Couvreur, Simona Mura, Julien Nicolas, 2013 .

Versatile and efficient targeting using a single nanoparticulate platform: application to cancer and Alzheimer's disease.

Cristina Airoldi, Patrick Couvreur, Simona Mura, 2012, ACS nano.

Study of the Influence of Several Stabilizing Agents on the Entrapment and InVitro Release of pBC 264 from Poly(Lactide-Co-Glycolide) Microspheres Prepared by a W/O/W Solvent Evaporation Method

P. Couvreur, E. Fattal, E. Leo, 1996, Pharmaceutical Research.

Characterization and morphological analysis of a cholecystokinin derivative peptide-loaded poly(lactide-co-glycolide) microspheres prepared by a water-in-oil-in-water emulsion solvent evaporation method

P. Couvreur, B. Roques, E. Fattal, 1997 .

Nano- and microparticles for the delivery of polypeptides and proteins

P. Couvreur, F. Puisieux, 1993 .

Multilamellar Nanoparticles Self-Assembled from Opposite Charged Blends: Insights from Mesoscopic Simulation

P. Couvreur, Xiaofang Zhang, R. Gref, 2015 .

Polymeric Micro- and Nanoparticles as Drug Carriers

P. Couvreur, G. Ponchel, P. Legrand, 2001 .

A unique squalenoylated and nonpegylated doxorubicin nanomedicine with systemic long-circulating properties and anticancer activity

P. Couvreur, F. Dosio, L. Cattel, 2014, Proceedings of the National Academy of Sciences.

Novel isoprenoyl nanoassembled prodrug for paclitaxel delivery.

Julie Mougin, Patrick Couvreur, Simona Mura, 2013, Bioconjugate chemistry.

Multicellular spheroid based on a triple co-culture: A novel 3D model to mimic pancreatic tumor complexity.

M. Matsusaki, M. Akashi, P. Couvreur, 2018, Acta biomaterialia.

Characterization of V3 BRU peptide-loaded small PLGA microspheres prepared by a (w1/o)w2 emulsion solvent evaporation method

P. Couvreur, E. Fattal, A. Gulik, 1994 .

Porous Metal–Organic Frameworks as New Drug Carriers

P. Couvreur, C. Serre, P. Horcajada, 2011 .

Encapsulation of mono- and oligo-nucleotides into aqueous-core nanocapsules in presence of various water-soluble polymers.

J. Janin, P. Couvreur, H. Hillaireau, 2007, International journal of pharmaceutics.

Encapsulation of antiviral nucleotide analogues azidothymidine-triphosphate and cidofovir in poly(iso-butylcyanoacrylate) nanocapsules.

J. Janin, P. Couvreur, H. Hillaireau, 2006, International journal of pharmaceutics.

"Smart" delivery of antisense oligonucleotides by anionic pH-sensitive liposomes.

P. Couvreur, E. Fattal, C. Dubernet, 2004, Advanced drug delivery reviews.

Delivery of antisense oligonucleotides by means of pH-sensitive liposomes

P. Couvreur, C. Ropert, C. Malvy, 1997 .

pH-sensitive liposomes as a carrier for oligonucleotides: a physico-chemical study of the interaction between DOPE and a 15-mer oligonucleotide in quasi-anhydrous samples.

P. Couvreur, P. Lesieur, E. Fattal, 1998, Biochimica et biophysica acta.

Innovative nanotechnologies for the delivery of oligonucleotides and siRNA.

N Toub, C Malvy, E Fattal, 2006, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Poly(alkylcyanoacrylates) as biodegradable materials for biomedical applications.

P. Couvreur, C. Vauthier, E. Fattal, 2003, Advanced drug delivery reviews.

A Druggable Pocket at the Nucleocapsid/Phosphoprotein Interaction Site of Human Respiratory Syncytial Virus

M. Tortorici, F. Rey, P. Couvreur, 2015, Journal of Virology.

Lipid conjugated oligonucleotides: a useful strategy for delivery.

P. Couvreur, D. Desmaële, L. Massaad-Massade, 2012, Bioconjugate chemistry.

Effect of polyisobutylcyanoacrylate nanoparticles and lipofectin loaded with oligonucleotides on cell viability and PKC alpha neosynthesis in HepG2 cells.

J. Féger, P. Couvreur, E. Fattal, 1998, Biochimie.

Retrovirus budding may constitute a port of entry for drug carriers.

P. Couvreur, C. Ropert, C. Malvy, 1996, Biochimica et biophysica acta.

Oligonucleotides encapsulated in pH sensitive liposomes are efficient toward Friend retrovirus.

P. Couvreur, C. Ropert, C. Malvy, 1992, Biochemical and biophysical research communications.

pH-sensitive liposomes as a carrier for oligonucleotides: a physico-chemical study of the interaction between DOPE and a 15-mer oligonucleotide in excess water.

P. Couvreur, P. Lesieur, C. Dubernet, 2000, Biophysical chemistry.

I. Arginine.

P. Couvreur, K. Tew, H. Tapiero, 2002, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Physicochemical characteristics and preliminary in vivo biological evaluation of nanocapsules loaded with siRNA targeting estrogen receptor alpha.

P. Opolon, E. Connault, P. Couvreur, 2008, Biomacromolecules.

A new nanomedicine based on didanosine glycerolipidic prodrug enhances the long term accumulation of drug in a HIV sanctuary.

A. Paci, G. Vassal, P. Couvreur, 2011, International journal of pharmaceutics.

Liposomal squalenoyl-gemcitabine: formulation, characterization and anticancer activity evaluation.

P. Couvreur, D. Desmaële, L. H. Reddy, 2010, Nanoscale.

Consequences of ions and pH on the supramolecular organization of sphingomyelin and sphingomyelin/cholesterol bilayers.

P. Couvreur, G. Pabst, M. Ollivon, 2008, Chemistry and physics of lipids.

Efficacy of siRNA Nanocapsules Targeted Against the EWS–Fli1 Oncogene in Ewing Sarcoma

P. Couvreur, A. Tamaddon, C. Malvy, 2006, Pharmaceutical Research.

Polyalkylcyanoacrylate Nanoparticles as Polymeric Carriers for Antisense Oligonucleotides

P. Couvreur, T. Doan, F. Puisieux, 1992, Pharmaceutical Research.

EWS fli-1 antisense nanocapsules inhibits ewing sarcoma-related tumor in mice.

P. Couvreur, C. Malvy, J. Bertrand, 2000, Biochemical and biophysical research communications.

Vidarabine-Loaded Nanoparticles: A Physicochemical Study

P. Couvreur, P. Dumont, V. Guise, 1990, Pharmaceutical Research.

Strategies to increase the oral bioavailability of nucleoside analogs.

P. Couvreur, K. Andrieux, M. Lalanne, 2009, Current Medicinal Chemistry.

Knocking Down TMPRSS2-ERG Fusion Oncogene by siRNA Could be an Alternative Treatment to Flutamide

P. Couvreur, I. de Waziers, D. Desmaële, 2016, Molecular therapy. Nucleic acids.

Preparation and characterization of biocompatible chitosan nanoparticles for targeted brain delivery of peptides.

P. Couvreur, T. Dalkara, Y. Capan, 2012, Methods in molecular biology.

Nanotechnologies for the treatment of colon cancer: From old drugs to new hope.

P. Couvreur, D. Desmaële, E. Chastre, 2016, International journal of pharmaceutics.

Antineoplastic Effects of siRNA against TMPRSS2-ERG Junction Oncogene in Prostate Cancer

P. Couvreur, D. Desmaële, L. Massaad-Massade, 2015, PloS one.

Preparation and Characterization of Novel Poly(methylidene Malonate 2.1.2.)-Made Nanoparticles

P. Couvreur, P. Bourrinet, F. Lescure, 1994, Pharmaceutical Research.

Pharmacokinetics and Distribution of a Biodegradable Drug-carrier

Patrick Couvreur, V. Lenaerts, P. Couvreur, 1983 .

Nanoprecipitation and the "Ouzo effect": Application to drug delivery devices.

Patrick Couvreur, P. Couvreur, E. Lepeltier, 2014, Advanced drug delivery reviews.

X-ray microfluorescence for biodistribution studies of nanomedicines.

P. Couvreur, D. Desmaële, G. Bastian, 2017, International journal of pharmaceutics.

Nanoplumbers: biomaterials to fight cardiovascular diseases

P. Couvreur, Flavio Dormont, M. Varna, 2017 .

Squalenoyl siRNA PMP22 nanoparticles are effective in treating mouse models of Charcot-Marie-Tooth disease type 1 A

M. Schumacher, P. Couvreur, L. Richard, 2021, Communications biology.

Nanotechnology for therapy and imaging of liver diseases.

P. Couvreur, L. H. Reddy, 2011, Journal of hepatology.

On the mechanism of action of doxorubicin encapsulation in nanospheres for the reversal of multidrug resistance

P. Couvreur, J. Robert, C. Dubernet, 1996, Cancer Chemotherapy and Pharmacology.

Novel self assembling nanoparticles for the oral administration of fondaparinux: Synthesis, characterization and in vivo evaluation

P. Couvreur, E. Lepeltier, J. Tranchant, 2014, Journal of controlled release : official journal of the Controlled Release Society.

Peptide conjugation: before or after nanoparticle formation?

P. Couvreur, F. Dosio, S. Arpicco, 2014, Bioconjugate chemistry.

In‐vitro evaluation of filaricidal activity of GABA and 1,3‐dipalmitoyl‐2‐(4‐aminobutyryl)glycerol HCl: a diglyceride prodrug

P. Couvreur, J. Benoit, P. Gayral, 1989, The Journal of pharmacy and pharmacology.

Nanocapsule technology: a review.

Elias Fattal, Christine Vauthier, Patrick Couvreur, 2002, Critical reviews in therapeutic drug carrier systems.

Improvement of in vivo stability of phosphodiester oligonucleotide using anionic liposomes in mice.

P. Couvreur, E. Fattal, D. Boquet, 2000, Life sciences.

In vitro investigation of multidrug nanoparticles for combined therapy with gemcitabine and a tyrosine kinase inhibitor: Together is not better.

P. Couvreur, B. Stella, S. Mura, 2016, Biochimie.

Simultaneous quantification of preactivated ifosfamide derivatives and of 4-hydroxyifosfamide by high performance liquid chromatography-tandem mass spectrometry in mouse plasma and its application to a pharmacokinetic study.

A. Paci, P. Couvreur, E. Daudigeos-Dubus, 2015, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Dual controlled delivery of squalenoyl-gemcitabine and paclitaxel using thermo-responsive polymeric micelles for pancreatic cancer.

P. Couvreur, G. Pasparakis, D. Desmaële, 2017, Journal of materials chemistry. B.

Preactivated oxazaphosphorines designed for isophosphoramide mustard delivery as bulk form or nanoassemblies: synthesis and proof of concept.

A. Paci, G. Vassal, P. Couvreur, 2015, Journal of medicinal chemistry.

Combinatorial Nanomedicine Made of Squalenoyl-Gemcitabine and Edelfosine for the Treatment of Osteosarcoma

P. Couvreur, F. Lecanda, D. Desmaële, 2020, Cancers.

Development of ciprofloxacin-loaded nanoparticles: physicochemical study of the drug carrier.

P. Couvreur, A. Andremont, H. Pinto-Alphandary, 1998, Journal of controlled release : official journal of the Controlled Release Society.

Therapeutic Opportunities in Neuroblastoma Using Nanotechnology

P. Couvreur, R. Noguera, M. Blanco-Prieto, 2019, The Journal of Pharmacology and Experimental Therapeutics.

Tissue distribution of antitumor drugs associated with polyalkylcyanoacrylate nanoparticles.

P Couvreur, V. Lenaerts, P. Couvreur, 1980, Journal of pharmaceutical sciences.

A unique multidrug nanomedicine made of squalenoyl-gemcitabine and alkyl-lysophospholipid edelfosine.

S. Irusta, P. Couvreur, V. Sebastián, 2019, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Synthesis of a Novel Poly(MePEG cyanoacrylate-co-alkyl cyanoacrylate) Amphiphilic Copolymer for Nanoparticle Technology‡

Patrick Couvreur, P. Couvreur, M. Peracchia, 1997 .

A new approach for the characterization of insoluble amphiphilic copolymers based on their emulsifying properties

P. Couvreur, C. Vauthier, D. Labarre, 2004 .

Adsorption of antineoplastic drugs to polyalkylcyanoacrylate nanoparticles and their release in calf serum.

P Couvreur, P. Couvreur, P. Speiser, 1979, Journal of pharmaceutical sciences.

Alkylcyanoacrylate drug carriers: II. Cytotoxicity of cyanoacrylate nanoparticles with different alkyl chain length

Rainer H. Müller, Patrick Couvreur, R. Müller, 1992 .

Toxicity of polyalkylcyanoacrylate nanoparticles II: Doxorubicin-loaded nanoparticles.

P. Couvreur, P. Speiser, B. Kante, 1982, Journal of pharmaceutical sciences.

Physico-chemical characterization of insulin-loaded poly(isobutylcyanoacrylate) nanocapsules obtained by interfacial polymerization.

P. Couvreur, C. Vauthier, F. Puisieux, 1999, International journal of pharmaceutics.

Characterization of alginate pregel by rheological investigation

P. Couvreur, C. Vauthier, G. Couarraze, 1994 .

[Influence of water penetration on the disintegration of tablets with a starchy base].

P. Couvreur, J. Gillard, M. Roland, 1975, Annales pharmaceutiques francaises.

Physicochemical characterization of ultrasmall superparamagnetic iron oxide particles (USPIO) for biomedical application as MRI contrast agents

M. Port, P. Couvreur, C. Sadun, 2007, International journal of nanomedicine.

Influence of the nanoprecipitation conditions on the supramolecular structure of squalenoyled nanoparticles.

P. Couvreur, H. Amenitsch, V. Rosilio, 2015, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Discovery of new hexagonal supramolecular nanostructures formed by squalenoylation of an anticancer nucleoside analogue.

Patrick Couvreur, P. Couvreur, J. Poupaert, 2008, Small.

Quantum dot-loaded PEGylated poly(alkyl cyanoacrylate) nanoparticles for in vitro and in vivo imaging

I. Maksimovic, P. Couvreur, E. Larquet, 2011 .

Biodegradation of Poly(alkylcyanoacrylates)

P. Couvreur, C. Vauthier, 2002 .

Pegylated Nanoparticles from a Novel Methoxypolyethylene Glycol Cyanoacrylate-Hexadecyl Cyanoacrylate Amphiphilic Copolymer

Christine Vauthier, Patrick Couvreur, P. Couvreur, 1998, Pharmaceutical Research.

Development of Novel Technologies for the Synthesis of Biodegradable Pegylated Nanoparticles

P. Couvreur, C. Vauthier, E. Fattal, 1998 .

Polymeric nanoparticulate system augmented the anticancer therapeutic efficacy of gemcitabine

P. Couvreur, J. Arias, L. H. Reddy, 2009, Journal of drug targeting.

Investigation of the formation of sterically stabilized poly(ethylene glycol/isobutyl cyanoacrylate) nanoparticles by chemical grafting of polyethylene glycol during the polymerization of isobutyl cyanoacrylate

P. Couvreur, C. Vauthier, M. Peracchia, 1997 .

Nanocapsules: A new type of lysosomotropic carrier

P. Couvreur, P. Speiser, M. Roland, 1977, FEBS letters.

Novel microparticulate system made of poly(methylidene malonate 2.1.2).

E Fattal, P Couvreur, P. Couvreur, 2001, Biomaterials.

Insulin‐loaded nanocapsules for oral administration: In vitro and in vivo investigation

P. Couvreur, B. Lacour, R. Farinotti, 2000 .

Study of the mechanism of insulin encapsulation in poly(isobutylcyanoacrylate) nanocapsules obtained by interfacial polymerization.

P. Couvreur, C. Vauthier, F. Puisieux, 1999, Journal of biomedical materials research.

Simultaneous use of size-exclusion chromatography and photon correlation spectroscopy for the characterization of poly(lactic acid) nanoparticles

P. Couvreur, C. Vauthier, D. Bazile, 1994 .

A new method to isolate polyalkylcyanoacrylate nanoparticle preparations.

P. Couvreur, H. Pinto-Alphandary, O. Balland, 1995, Journal of drug targeting.

Study of the mechanisms of formation of nanoparticles and nanocapsules of polyisobutyl-2-cyanoacrylate

P. Couvreur, F. Puisieux, G. Couarraze, 1993 .

Optimization of polyalkylcyanoacrylate nanoparticle preparation: Influence of sulfur dioxide and pH on nanoparticle characteristics

C. Zimmer, P. Couvreur, F. Lescure, 1992 .

Design of fluorescently tagged poly(alkyl cyanoacrylate) nanoparticles for human brain endothelial cell imaging.

P. Couvreur, P. Couraud, B. Le Droumaguet, 2010, Chemical communications.

Self-assembled nucleolipids: from supramolecular structure to soft nucleic acid and drug delivery devices

Patrick Couvreur, P. Couvreur, Vanessa Allain, 2011, Nucleic acids research.

Multicellular tumor spheroids: a relevant 3D model for the in vitro preclinical investigation of polymer nanomedicines

Patrick Couvreur, Gianpiero Lazzari, Simona Mura, 2017 .

Cyclodextrin and polysaccharide-based nanogels: entrapment of two hydrophobic molecules, benzophenone and tamoxifen.

Ruxandra Gref, Patrick Couvreur, P. Couvreur, 2009, Biomacromolecules.

New magnetic drug carrier

P. Couvreur, P. Speiser, M. Roland, 1983, The Journal of pharmacy and pharmacology.

Long-living intermediates during a lamellar to a diamond-cubic lipid phase transition: a small-angle X-ray scattering investigation.

S. Lesieur, P. Couvreur, A. Angelova, 2009, Langmuir : the ACS journal of surfaces and colloids.

Increased cytotoxicity of nanoparticle-carried Adriamycin in vitro and potentiation by verapamil and amiodarone.

P. Couvreur, B. Clausse, C. Kubiak, 1989, Biomaterials.

Squalenoyl Adenosine Nanoparticles provide Neuroprotection after Stroke and Spinal Cord Injury

P. Couvreur, V. Nicolas, N. Hildebrandt, 2014, Nature nanotechnology.

Fe3O4/chitosan nanocomposite for magnetic drug targeting to cancer

Patrick Couvreur, P. Couvreur, J. Arias, 2012 .

A new painkiller nanomedicine to bypass the blood-brain barrier and the use of morphine

M. Hamon, P. Couvreur, S. Mura, 2019, Science Advances.

Dual delivery of nucleic acids and PEGylated-bisphosphonates via calcium phosphate nanoparticles

P. Couvreur, J. Leroux, S. Bisso, 2019, bioRxiv.

N-methylation of anthracyclines modulates their cytotoxicity and pharmacokinetic in wild type and multidrug resistant cells.

P. Couvreur, H. Tapiero, L. Gaté, 2003, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Therapeutic Potentialities of EWS‐Fli‐1 mRNA‐Targeted Vectorized Antisense Oligonucleotides

P. Couvreur, C. Malvy, J. Bertrand, 2003, Annals of the New York Academy of Sciences.

PEGylated squalenoyl-gemcitabine nanoparticles for the treatment of glioblastoma.

P. Couvreur, W. Saltzman, R. Bindra, 2016, Biomaterials.

Nanoparticles: heating tumors to death?

Nicolas Tsapis, Christine Vauthier, Patrick Couvreur, 2011, Nanomedicine.

Synthesis and aqueous organization of 1,3-dipalmitoyl-2-(4-aminobutyryl) glycerol·HCl: a diglyceride prodrug

P. Couvreur, J. Benoit, A. Gulik, 1991 .

Capillary electrophoresis monitoring of the competitive adsorption of albumin onto the orosomucoid‐coated polyisobutylcyanoacrylate nanoparticles

P. Couvreur, C. Vauthier, M. Taverna, 1994, Electrophoresis.

Quantification of tetramethyl-terephthalic acid in rat liver, spleen and urine matrices by liquid-liquid phase extraction and HPLC-photodiode array detection.

P. Couvreur, C. Serre, P. Horcajada, 2012, Journal of pharmaceutical and biomedical analysis.

Quantification of fumaric acid in liver, spleen and urine by high-performance liquid chromatography coupled to photodiode-array detection.

P. Couvreur, C. Serre, P. Horcajada, 2011, Journal of pharmaceutical and biomedical analysis.

Optimisation of the synthesis of MOF nanoparticles made of flexible porous iron fumarate MIL-88A

Ruxandra Gref, Patrick Couvreur, Christian Serre, 2011 .

“Squalenoylcurcumin” Nanoassemblies as Water‐Dispersible Drug Candidates with Antileishmanial Activity

P. Couvreur, D. Desmaële, S. Cojean, 2015, ChemMedChem.

Development and brain delivery of chitosan-PEG nanoparticles functionalized with the monoclonal antibody OX26.

Patrick Couvreur, Maria Jose Alonso, Turgay Dalkara, 2005, Bioconjugate chemistry.

In vitro determination of the CYP 3A4 activity in rat hepatic microsomes by liquid-phase extraction and HPLC-photodiode array detection.

P. Couvreur, C. Serre, P. Horcajada, 2012, Journal of pharmacological and toxicological methods.

Effect of nanoparticles binding β-amyloid peptide on nitric oxide production by cultured endothelial cells and macrophages

M. Masserini, P. Couvreur, F. Re, 2013, International journal of nanomedicine.

Antibody-functionalized polymer nanoparticle leading to memory recovery in Alzheimer's disease-like transgenic mouse model.

M. Masserini, G. Forloni, P. Couvreur, 2017, Nanomedicine : nanotechnology, biology, and medicine.

Sustained delivery of growth factors from methylidene malonate 2.1.2-based polymers.

David Bonnafous, P. Couvreur, E. Fattal, 2006, Biomaterials.

PEGylated nanoparticles bind to and alter amyloid-beta peptide conformation: toward engineering of functional nanomedicines for Alzheimer's disease.

W. Scheper, M. Gobbi, P. Couvreur, 2012, ACS nano.

In vitro evaluation of nanoparticles spleen capture.

P Couvreur, P. Couvreur, B. Gouritin, 1999, Life sciences.

Polysaccharide-decorated nanoparticles.

Ruxandra Gref, Patrick Couvreur, P. Couvreur, 2004, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Inhibition of the Friend Retrovirus by Antisense Oligonucleotides Encapsulated in Liposomes: Mechanism of Action

P. Couvreur, C. Ropert, C. Malvy, 1993, Pharmaceutical Research.

Protection of insulin from enzymatic degradation by its association to liposomes

P. Couvreur, J. Delattre, F. Puisieux, 1985 .

Nanomedicines and stroke: Toward translational research

P. Couvreur, A. Gaudin, K. Andrieux, 2015 .

[Mechanism of disintegration of tablets with a starch base].

P. Couvreur, J. Gillard, H. G. Van den Schrieck, 1974, Journal de pharmacie de Belgique.

Nanomaterials: Applications in Drug Delivery

P. Couvreur, C. Vauthier, E. Fattal, 2013 .

Tamoxifen encapsulation within polyethylene glycol-coated nanospheres. A new antiestrogen formulation.

R. Gurny, P. Couvreur, M. Besnard, 2001, International journal of pharmaceutics.

Study of the Breakup Under Shear of a New Thermally Reversible Water-in-Oil-in-Water (W/O/W) Multiple Emulsion

P. Couvreur, L. Bromberg, J. Grossiord, 2001, Pharmaceutical Research.

Metallic colloid nanotechnology, applications in diagnosis and therapeutics.

Paolo Colombo, Patrick Couvreur, Catherine Dubernet, 2005, Current pharmaceutical design.

Colloidal properties of biodegradable nanoparticles influence interaction with amyloid-β peptide.

P. Couvreur, B. Le Droumaguet, J. Nicolas, 2011, Journal of biotechnology.

Formulation of Didanosine Prodrugs into PEGylated Poly(alkyl cyanoacrylate) Nanoparticles and Uptake by Brain Endothelial Cells

P. Couvreur, V. Nicolas, J. Nicolas, 2009 .

Facile Synthesis of Innocuous Comb-Shaped Polymethacrylates with PEG Side Chains by Nitroxide-Mediated Radical Polymerization in Hydroalcoholic Solutions

D. Gigmes, P. Couvreur, E. Fattal, 2010 .

Investigation of squalene-doxorubicin distribution and interactions within single cancer cell using Raman microspectroscopy.

P. Couvreur, F. Dosio, B. Stella, 2021, Nanomedicine : nanotechnology, biology, and medicine.

Squalenoylation: A Novel Technology for Anticancer and Antibiotic Drugs with Enhanced Activity

P. Couvreur, 2016 .

Simultaneous determination of gemcitabine and gemcitabine-squalene by liquid chromatography-tandem mass spectrometry in human plasma.

A. Paci, G. Vassal, P. Couvreur, 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Anti-HIV efficacy and biodistribution of nucleoside reverse transcriptase inhibitors delivered as squalenoylated prodrug nanoassemblies.

P. Couvreur, H. Hillaireau, K. Andrieux, 2013, Biomaterials.

Anticancer efficacy of squalenoyl gemcitabine nanomedicine on 60 human tumor cell panel and on experimental tumor.

P. Couvreur, J. Renoir, D. Desmaële, 2009, Molecular pharmaceutics.

Magnetoresponsive squalenoyl gemcitabine composite nanoparticles for cancer active targeting.

P. Couvreur, J. Arias, L. H. Reddy, 2008, Langmuir : the ACS journal of surfaces and colloids.

The Stenlying Effect of High Hydrostatic Pressure on Thermally and Hydrolytically Labile Nanosized Carriers

P. Couvreur, M. Besnard, I. Brigger, 2003, Pharmaceutical Research.

A Nanomedicine Transports a Peptide Caspase-3 Inhibitor across the Blood–Brain Barrier and Provides Neuroprotection

Patrick Couvreur, Turgay Dalkara, Ebru Bodur, 2009, The Journal of Neuroscience.

Dual delivery of nucleic acids and PEGylated-bisphosphonates via calcium phosphate nanoparticles

P. Couvreur, J. Leroux, S. Bisso, 2019, bioRxiv.

Some physicochemical properties of polyalkylcyanoacrylate nanospheres and nanocapsules

P. Couvreur, F. Puisieux, L. Roblot, 1988 .

Selegiline-functionalized, PEGylated poly(alkyl cyanoacrylate) nanoparticles: Investigation of interaction with amyloid-β peptide and surface reorganization.

P. Couvreur, B. Le Droumaguet, J. Nicolas, 2011, International journal of pharmaceutics.

Squalene-based multidrug nanoparticles for improved mitigation of uncontrolled inflammation in rodents

P. Couvreur, J. Mougin, C. Cailleau, 2020, Science Advances.

Submicron Cationic Emulsions as a New Delivery System for Oligonucleotides

P. Couvreur, S. Benita, H. Teixeira, 2004, Pharmaceutical Research.

Facile synthesis of multicompartment micelles based on biocompatible poly(3-hydroxyalkanoate).

P. Couvreur, B. Le Droumaguet, V. Langlois, 2013, Macromolecular rapid communications.

Synthesis of Highly Functionalized Poly(alkyl cyanoacrylate) Nanoparticles by Means of Click Chemistry

P. Couvreur, C. Detrembleur, J. Nicolas, 2008 .

A computationally derived structural model of doxorubicin interacting with oligomeric polyalkylcyanoacrylate in nanoparticles.

P. Couvreur, J. Poupaert, 2003, Journal of controlled release : official journal of the Controlled Release Society.

Positively charged cyclodextrins as effective molecular transporters of active phosphorylated forms of gemcitabine into cancer cells

G. Salzano, P. Couvreur, K. Yannakopoulou, 2017, Scientific Reports.

About the alleged toxicity of aluminium-based adjuvants in vaccines: all published studies should be taken into account.

P. Couvreur, J. Goullé, L. Grangeot‐Keros, 2021, International journal of pharmaceutics.

Cover Picture: Squalenyl Hydrogen Sulfate Nanoparticles for Simultaneous Delivery of Tobramycin and an Alkylquinolone Quorum Sensing Inhibitor Enable the Eradication of P. aeruginosa Biofilm Infections (Angew. Chem. Int. Ed. 26/2020)

R. Hartmann, P. Couvreur, R. Müller, 2020 .

Synthesis and Biopharmaceutical Characterization of Amphiphilic Squalenyl Derivative Based Versatile Drug Delivery Platform

P. Couvreur, C. Lehr, B. Loretz, 2020, Frontiers in Chemistry.

Nanoparticulate systems for the delivery of antisense oligonucleotides.

P. Couvreur, E. Fattal, G. Lambert, 2001, Advanced drug delivery reviews.

Precise Engineering of Multifunctional PEGylated Polyester Nanoparticles for Cancer Cell Targeting and Imaging

P. Couvreur, J. Nicolas, J. Mougin, 2014 .

Light sheet fluorescent microscopy versus confocal microscopy: in quest of a suitable tool to assess drug and nanomedicine penetration into multicellular tumor spheroids.

P. Couvreur, V. Nicolas, Nicolas Goudin, 2019, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Chapter 1:Historical View of the Design and Development of Nanocarriers for Overcoming Biological Barriers

María J. Alonso, Patrick Couvreur, P. Couvreur, 2012 .

Pharmacokinetics, biodistribution and metabolism of squalenoyl adenosine nanoparticles in mice using dual radio-labeling and radio-HPLC analysis

P. Couvreur, A. Gaudin, J. Mougin, 2015, Journal of controlled release : official journal of the Controlled Release Society.

In Vivo FRET Imaging to Predict the Risk Associated with Hepatic Accumulation of Squalene‐Based Prodrug Nanoparticles

P. Couvreur, A. Klymchenko, S. Mura, 2018, Advanced healthcare materials.

Albumin-driven disassembly of lipidic nanoparticles: the specific case of the squalene-adenosine nanodrug.

P. Couvreur, I. Grillo, F. Wien, 2020, Nanoscale.

Polyalkylcyanoacrylate nanoparticles for delivery of drugs across the blood-brain barrier.

Patrick Couvreur, P. Couvreur, K. Andrieux, 2009, Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology.

Toxicity of polyalkylcyanoacrylate nanoparticles I: Free nanoparticles.

P. Couvreur, P. Speiser, M. Roland, 1982, Journal of pharmaceutical sciences.

Special Section on Drug Delivery Technologies — Minireview Therapeutic Opportunities in Neuroblastoma Using Nanotechnology

P. Couvreur, R. Noguera, M. Blanco-Prieto, 2019 .

Ability of Doxorubicin-Loaded Nanoparticles to Overcome Multidrug Resistance of Tumor Cells After Their Capture by Macrophages

P. Couvreur, S. Benita, G. Barratt, 1999, Pharmaceutical Research.

P oly ( alkylcyanoacrylates ) as biodegradable materials for biomedical applications

P. Couvreur, C. Vauthier, E. Fattal, 2003 .

Self-assembly of squalene-based nucleolipids: relating the chemical structure of the bioconjugates to the architecture of the nanoparticles.

P. Couvreur, J. Poupaert, F. Meneau, 2013, Langmuir : the ACS journal of surfaces and colloids.

Nanotechnologies for drug delivery: Application to cancer and autoimmune diseases

P. Couvreur, C. Malvy, K. Andrieux, 2006 .

Measurement of the Density of Polymeric Nanoparticulate Drug Carriers by Isopycnic Centrifugation

Christine Vauthier, Patrick Couvreur, C. Schmidt, 1999 .

Bioadhesive properties of poly(alkylcyanoacrylate) nanoparticles coated with polysaccharide.

P. Couvreur, G. Ponchel, C. Vauthier, 2006, Journal of nanoscience and nanotechnology.

[Perspective on the use of microdisperse forms as intracellular vehicles].

P. Couvreur, M. Roland, B. Kanté, 1978, Pharmaceutica acta Helvetiae.

In vitro and in vivo Evaluation of Poly(Methylidene Malonate 2.1.2) Microparticles Behavior for Oral Administration

P. Couvreur, E. Fattal, C. Le Visage, 2001, Journal of drug targeting.

Research Papers Alkylcyanoacrylate drug carriers: I. Physicochemical characterization of nanoparticles with different alkyl chain length

P. Couvreur, T. Blunk, C. Lherm, 1992 .

Quantification and localization of PEGylated polycyanoacrylate nanoparticles in brain and spinal cord during experimental allergic encephalomyelitis in the rat

Patrick Couvreur, P. Couvreur, C. Klein, 2002, The European journal of neuroscience.

Small-angle neutron and X-ray scattering from amphiphilic stimuli-responsive diamond-type bicontinuous cubic phase.

S. Lesieur, P. Couvreur, S. Funari, 2007, Journal of the American Chemical Society.

Polymeric Nanoparticles and Microspheres

P. Couvreur, P. Guiot, 2018 .

A methodology to study intracellular distribution of nanoparticles in brain endothelial cells.

Patrick Couvreur, Frédéric Taran, P. Couvreur, 2005, International journal of pharmaceutics.

Supramolecular organization and biological interaction of squalenoyl siRNA nanoparticles.

P. Couvreur, F. Wien, M. Hémadi, 2021, International journal of pharmaceutics.

Assessment of Squalene-Adenosine Nanoparticles in Two Rodent Models of Cardiac Ischemia-Reperfusion

P. Couvreur, V. Nicolas, C. Cailleau, 2023, Pharmaceutics.

Colloidal stability of ultrasmall superparamagnetic iron oxide (USPIO) particles with different coatings.

C. Robic, M. Port, P. Couvreur, 2007, International journal of pharmaceutics.

Dual controlled delivery of squalenoyl-gemcitabine and paclitaxel using thermo-responsive polymeric micelles for pancreatic cancer

P. Couvreur, G. Pasparakis, D. Desmaële, 2017 .

Heparin coated poly(alkylcyanoacrylate) nanoparticles coupled to hemoglobin: a new oxygen carrier.

Christine Vauthier, Patrick Couvreur, Denis Labarre, 2004, Biomaterials.

Busulfan loading into poly(alkyl cyanoacrylate) nanoparticles: physico-chemistry and molecular modeling.

P. Couvreur, J. Poupaert, N. Ghermani, 2006, Journal of biomedical materials research. Part B, Applied biomaterials.

Molecular Reactivity of Busulfan Through Its Experimental Electrostatic Properties in the Solid State

P. Couvreur, N. Ghermani, R. Gref, 2004, Pharmaceutical Research.

Nanoencapsulation of a crystalline drug.

P. Couvreur, A. Domb, M. Appel, 2005, International journal of pharmaceutics.

N anoparticles in cancer therapy and diagnosis

P. Couvreur, C. Dubernet, I. Brigger, 2002 .

Cell cultures for the assessment of toxicity and uptake of polymeric particulate drug carriers

R. Müller, P. Couvreur, E. Fattal, 1993 .

[Targeting bone marrow with the help of polyalkylcyanoacrylate nanoparticles].

P. Couvreur, J. Andreux, C. Weingarten, 1999, Annales pharmaceutiques francaises.

Self-assembled lipid–prodrug nanoparticles

P. Couvreur, E. Garbayo, M. Blanco-Prieto, 2023, Nature Reviews Bioengineering.

Cationic emulsions improves the delivery of oligonucleotides to leukemic P388/ADR cells in ascite.

L. Rabinovich, P. Couvreur, S. Benita, 2003, Journal of Controlled Release.

New Enkephalin Nanomedicines for Pain Alleviation, Overcoming the Side Effects of Morphine

P. Couvreur, Jiao Feng, S. Lepetre-Mouelhi, 2021 .

Plasma membrane lipid bilayer is druggable: Selective delivery of gemcitabine-squalene nano-medicine to cancer cells.

P. Couvreur, K. Pyrshev, S. Yesylevskyy, 2023, Biochimica et biophysica acta. Molecular basis of disease.

Turning Squalene into Cationic Lipid Allows a Delivery of siRNA in Cultured Cells.

P. Couvreur, Catherine Durieu, C. Malvy, 2015, Nucleic acid therapeutics.

Peptide-functionalized nanoparticles for selective targeting of pancreatic tumor.

P. Couvreur, E. Giraudo, L. Cattel, 2014, Journal of controlled release : official journal of the Controlled Release Society.

Patrick Couvreur: inspiring pharmaceutical innovation

P. Couvreur, 2014 .

Effects of siRNA on RET/PTC3 Junction Oncogene in Papillary Thyroid Carcinoma: From Molecular and Cellular Studies to Preclinical Investigations

P. Couvreur, J. Bertrand, L. Massaad-Massade, 2014, PloS one.

Oral absorption and tissue distribution of a new squalenoyl anticancer nanomedicine

P. Couvreur, C. Dubernet, D. Desmaële, 2008 .

Nanoparticles of therapeutic assets of low aqueous solubility

P. Couvreur, F. Dosio, L. Cattel, 2007 .

Tissue distribution of doxorubicin associated with polyisohexylcyanoacrylate nanoparticles

P. Couvreur, F. Brasseur, M. Roland, 2008, Cancer Chemotherapy and Pharmacology.

Drug Delivery: Nanoparticles of Metal-Organic Frameworks: On the Road to In Vivo Efficacy in Biomedicine (Adv. Mater. 37/2018)

P. Couvreur, C. Serre, Angelika Mielcarek, 2018, Advanced Materials.

Plug-in Spectrometry with Optical Fibers as a Novel Analytical Tool for Nanoparticles Technology: Application to the Investigation of the Emulsion Polymerization of the Alkylcyanoacrylate

Christine Vauthier, Patrick Couvreur, Denis Labarre, 2003 .

In Vivo Potentialities of EWS‐Fli‐1 Targeted Antisense Oligonucleotides‐Nanospheres Complexes

P. Couvreur, C. Malvy, J. Bertrand, 2005, Annals of the New York Academy of Sciences.

[The effect of kinetics of water absorption on the disintegration of pharmaceutic tablets with a starch base].

P. Couvreur, J. Gillard, M. Roland, 1976, Annales pharmaceutiques francaises.

Poly-isoprenylated ifosfamide analogs: Preactivated antitumor agents as free formulation or nanoassemblies.

J. Delahousse, A. Paci, P. Couvreur, 2017, International journal of pharmaceutics.

Optimization of the encapsulation and release of beta-lactoglobulin entrapped poly(DL-lactide-co-glycolide) microspheres.

P. Couvreur, E. Fattal, E. Leo, 1999, International journal of pharmaceutics.

Development of a quantitative polyacrylamide gel electrophoresis analysis using a multichannel radioactivity counter for the evaluation of oligonucleotide-bound drug carrier.

P. Couvreur, C. Malvy, C. Vauthier, 1996, Analytical biochemistry.

Implant Materials in Biofunction: Advances in Biomaterials 8, Editors: C. de Putter, G.L. Lange, K. de Groot and A.J.C. Lee Elsevier, Amsterdam, 1988, pp 522, DFL 365.00

P Couvreur, P. Couvreur, 1989 .

Liposomally entrapped adenosine triphosphate. Improved efficiency against experimental brain ischaemia in the rat.

P. Couvreur, E. Fattal, J. Delattre, 1988, Journal of chromatography.

Delivery of Antisense Oligonucleotides in Vitro

P. Couvreur, C. Malvy, 2003 .

Dynamic control of nanofluidic channels in protein drug delivery vehicles

S. Lesieur, P. Couvreur, A. Angelova, 2008 .

Nanoparticles for the Delivery of Peptides and Proteins

P. Couvreur, F. Puisieux, 1994 .

Development of dehydroemetine nanoparticles for the treatment of visceral leishmaniasis.

P. Couvreur, M. Roland, H. Vranckx, 1989, Journal of microencapsulation.

Nanotechnologies for Alzheimer's disease: diagnosis, therapy, and safety issues.

P. Couvreur, B. Le Droumaguet, S. Moghimi, 2011, Nanomedicine : nanotechnology, biology, and medicine.

Selegiline-functionalized, PEGylated poly(alkyl cyanoacrylate) nanoparticles: Investigation of interaction with amyloid-β peptide and surface reorganization.

P. Couvreur, B. Le Droumaguet, J. Nicolas, 2011, International journal of pharmaceutics.

Application of thermal analysis to the study of lipidic prodrug incorporation into nanocarriers

P. Couvreur, J. Nicolas, K. Andrieux, 2009 .

Interactions of anticancer drugs with biomembranes: what can we learn from model membranes?

P. Couvreur, C. Bourgaux, 2014, Journal of controlled release : official journal of the Controlled Release Society.

Squalenoylation Favorably Modifies the in Vivo Pharmacokinetics and Biodistribution of Gemcitabine in Mice

A. Paci, G. Vassal, P. Couvreur, 2008, Drug Metabolism and Disposition.

Phospholipid hydrolysis in a pharmaceutical emulsion assessed by physicochemical parameters and a new analytical method.

P. Couvreur, C. Dubernet, K. Gaudin, 2005, European journal of pharmaceutics and biopharmaceutics.

Nanotechnologies for the treatment of colon cancer: From old drugs to new hope.

P. Couvreur, D. Desmaële, E. Chastre, 2016, International journal of pharmaceutics.

Versatile and efficient targeting using a single nanoparticulate platform: application to cancer and Alzheimer's disease.

M. Masserini, W. Scheper, M. Gobbi, 2012, ACS nano.

Novel core(polyester)-shell(polysaccharide) nanoparticles: protein loading and surface modification with lectins.

P. Couvreur, G. Ponchel, R. Gref, 2003, Journal of controlled release : official journal of the Controlled Release Society.

Polymer-based nanoparticles for the delivery of nucleoside analogues.

P. Couvreur, H. Hillaireau, T. Le Doan, 2006, Journal of nanoscience and nanotechnology.

In vitro evaluation of nanoparticle formulations containing gangliosides.

P. Couvreur, L. Callegaro, L. Benedetti, 1994, Journal of drug targeting.

Theoretical and experimental study of beveled thyristor structures

P. Couvreur, F. Wiele, 1979 .

Peptide-functionalized nanoparticles for selective targeting of pancreatic tumor.

P. Couvreur, E. Giraudo, L. Cattel, 2014, Journal of controlled release : official journal of the Controlled Release Society.

NANO-OBJECTS IN BIOLOGICAL FLUIDS: FROM DETECTION OF ENDOGENOUS VESICLES TO NANOTOXICITY OF EXOGENOUS NANOPARTICLES

P. Couvreur, I. Grillo, F. Wien, 2019 .

Synthesis of Highly Functionalized Poly(alkyl cyanoacrylate) Nanoparticles by Means of Click Chemistry

P. Couvreur, C. Detrembleur, J. Nicolas, 2008 .

Synthesis and biological evaluation of two glycerolipidic prodrugs of didanosine for direct lymphatic delivery against HIV.

A. Paci, G. Vassal, P. Couvreur, 2007, Bioorganic & medicinal chemistry letters.

BioMOFs: metal-organic frameworks for biological and medical applications.

P. Couvreur, C. Serre, Alistair C. McKinlay, 2010, Angewandte Chemie.

Nanomedicines for Pediatric Cancers.

P. Couvreur, A. Aldaz, M. Blanco-Prieto, 2018, ACS nano.

Inhibition of the Friend Retrovirus by Antisense Oligonucleotides.

P. Couvreur, C. Ropert, C. Malvy, 1992, Annals of the New York Academy of Sciences.

Antisense oligonucleotide nanocapsules efficiently inhibit EWS-Fli1 expression in a Ewing's sarcoma model.

P. Couvreur, C. Malvy, J. Bertrand, 2006, Oligonucleotides.