S. Hadano

S. Hadano, J. Ikeda, Kazunori Tanaka, 2005, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Genetic and clinical characteristics of ALS patients with NEK1 gene variants

H. Shang, S. Hadano, Yanbing Hou, 2022, Neurobiology of Aging.

Rostrocaudal Areal Patterning of Human PSC-Derived Cortical Neurons by FGF8 Signaling

H. Okano, S. Hadano, H. Miyajima, 2018, eNeuro.

De-erosion of X chromosome dosage compensation by the editing of XIST regulatory regions restores the differentiation potential in hPSCs

S. Hadano, A. Umezawa, A. Fukuda, 2022, Cell reports methods.

HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis.

S. Hersch, M. Hayden, B. Leavitt, 2002, Human molecular genetics.

Cell death attenuation by `Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex

M. Hayden, S. Hadano, B. Koop, 1998, Cell Death and Differentiation.

Alopecia areata susceptibility variant in MHC region impacts expressions of genes contributing to hair keratinization and is involved in hair loss

S. Beck, S. Mano, H. Inoko, 2020, EBioMedicine.

Alopecia areata susceptibility variant identified by MHC risk haplotype sequencing reproduces symptomatic patched hair loss in mice

S. Beck, S. Mano, H. Inoko, 2018, bioRxiv.

Persistent production of hypoxanthine in rat skeletal muscle causes prolonged hyperuricemia after an exhaustive exercise.

S. Hadano, M. Itakura, H. Goto, 1989 .

Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent

H. Okano, G. Sobue, H. Saya, 2018, Nature Medicine.

ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics.

Shuh Narumiya, Takeharu Nishimoto, Asako Otomo, 2003, Human molecular genetics.

The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter.

Y. Gondo, S. Hadano, J. Ikeda, 2000, Genomics.

Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent

H. Okano, G. Sobue, H. Saya, 2018, Nature Medicine.

Six SQSTM1 mutations in a Chinese amyotrophic lateral sclerosis cohort

S. Hadano, N. Zhang, D. Fan, 2015, Amyotrophic lateral sclerosis & frontotemporal degeneration.

Dysregulation of the Autophagy-Endolysosomal System in Amyotrophic Lateral Sclerosis and Related Motor Neuron Diseases

S. Hadano, A. Otomo, Lei Pan, 2012, Neurology research international.

Identification and characterization of the miniature pig Huntington's disease gene homolog: evidence for conservation and polymorphism in the CAG triplet repeat.

Y. Gondo, S. Hadano, J. Ikeda, 2000, Genomics.

Laser microdissection and single unique primer PCR allow generation of regional chromosome DNA clones from a single human chromosome.

I. Kanazawa, S. Hadano, J. Ikeda, 1991, Genomics.

Unstable transmission of the RS447 human megasatellite tandem repetitive sequence that contains the USP17 deubiquitinating enzyme gene

I. Kanazawa, Y. Gondo, S. Hadano, 2002, Human Genetics.

Mutation Screening of the CHCHD10 Gene in Chinese Patients with Amyotrophic Lateral Sclerosis

Jing Yang, H. Shang, S. Hadano, 2016, Molecular Neurobiology.

Molecular and cellular function of ALS2/alsin: Implication of membrane dynamics in neuronal development and degeneration

Asako Otomo, S. Hadano, J. Ikeda, 2007, Neurochemistry International.

A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2

S. Scherer, Robert H. Brown, M. Hayden, 2001, Nature Genetics.

Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2.

S. Scherer, M. Hayden, G. Rouleau, 2001, Genomics.

The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis

S. Scherer, Robert H. Brown, M. Hayden, 2001, Nature Genetics.

Functional human NAIP promoter transcription regulatory elements for the NAIP and PsiNAIP genes.

S. Hadano, J. Ikeda, Y. Yanagisawa, 2002, Biochimica et biophysica acta.

Transcript map of the human chromosome 4p16.3 consisting of 627 cDNA clones derived from 1 Mb of the Huntington's disease locus.

K. Yamamoto, S. Hadano, J. Ikeda, 1996, DNA research : an international journal for rapid publication of reports on genes and genomes.

Homo-oligomerization of ALS2 through Its Unique Carboxyl-terminal Regions Is Essential for the ALS2-associated Rab5 Guanine Nucleotide Exchange Activity and Its Regulatory Function on Endosome Trafficking*

Asako Otomo, S. Hadano, J. Ikeda, 2004, Journal of Biological Chemistry.

AI-based protein structure databases have the potential to accelerate rare diseases research: AlphaFoldDB and the case of IAHSP/Alsin.

S. Hadano, G. Caron, G. Ermondi, 2021, Drug discovery today.

SQSTM1L341V variant that is linked to sporadic ALS exhibits impaired association with MAP1LC3 in cultured cells

H. Shang, S. Hadano, Xueping Chen, 2020, eNeurologicalSci.

Systemic overexpression of SQSTM1/p62 accelerates disease onset in a SOD1H46R-expressing ALS mouse model

G. Sobue, H. Shang, S. Hadano, 2018, Molecular Brain.

A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2

S. Hadano, S. Hadano, 2001, Nature Genetics.

High-throughput quantitative analysis of axonal transport in cultured neurons from SOD1H46R ALS mice by using a microfluidic device

S. Hadano, Shun Mitsui, A. Otomo, 2021, Neuroscience Research.

Loss of glial fibrillary acidic protein marginally accelerates disease progression in a SOD1 H46R transgenic mouse model of ALS

S. Hadano, M. Ohtsuka, A. Otomo, 2011, Neuroscience Research.

The Rab5 Activator ALS2/alsin Acts as a Novel Rac1 Effector through Rac1-activated Endocytosis*

S. Hadano, J. Ikeda, A. Otomo, 2007, Journal of Biological Chemistry.

ALS2CL, a novel ALS2-interactor, modulates ALS2-mediated endosome dynamics.

S. Hadano, J. Ikeda, H. Osuga, 2007, Biochemical and biophysical research communications.

ALS2CL, the novel protein highly homologous to the carboxy‐terminal half of ALS2, binds to Rab5 and modulates endosome dynamics

S. Hadano, J. Ikeda, Y. Yanagisawa, 2004, FEBS letters.

EFFECTS OF EXERCISE INTENSITY ON PURINE CATABOLISM

S. Hadano, A. Ito, M. Ogasawara, 1988 .

Mice deficient in the Rab5 guanine nucleotide exchange factor ALS2/alsin exhibit age-dependent neurological deficits and altered endosome trafficking.

Robert H. Brown, S. Hadano, J. Shefner, 2006, Human molecular genetics.

A novel small molecule, N-(4-(2-pyridyl)(1,3-thiazol-2-yl))-2-(2,4,6-trimethylphenoxy) acetamide, selectively protects against oxidative stress-induced cell death by activating the Nrf2-ARE pathway: therapeutic implications for ALS.

S. Hadano, J. Ikeda, Kazunori Tanaka, 2012, Free radical biology & medicine.

Aberration of miRNAs Expression in Leukocytes from Sporadic Amyotrophic Lateral Sclerosis

H. Shang, S. Hadano, Xueping Chen, 2016, Front. Mol. Neurosci..

Single-nucleotide polymorphisms in uncoding regions of ALS2 gene of Japanese patients with autosomal-recessive amyotrophic lateral sclerosis

Koji Abe, Isao Nagano, Yasuhiro Manabe, 2003, Neurological research.

A yeast artificial chromosome-based physical map of the juvenile amyotrophic lateral sclerosis (ALS2) critical region on human chromosome 2q33-q34.

S. Scherer, M. Hayden, R. Brinkman, 1999, Genomics.

ALS2/alsin deficiency in neurons leads to mild defects in macropinocytosis and axonal growth.

S. Hadano, J. Ikeda, H. Osuga, 2008, Biochemical and biophysical research communications.

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

Sara W. Bird, Erinna F. Lee, Michael D. Kim, 2016 .

Efficient differentiation and polarization of primary cultured neurons on poly(lactic acid) scaffolds with microgrooved structures

S. Hadano, T. Fujie, S. Takeoka, 2019, bioRxiv.

Purification and functional analyses of ALS2 and its homologue.

S. Hadano, J. Ikeda, 2005, Methods in enzymology.

Editorial :Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). DOI: 10.1080/15548627.2015.1100356;WOS:000373595400001; 2-s2.0-85013763791&;PMID: 26799652

Lee, Duchen, Izzo, 2016 .

A novel function of N-linked glycoproteins, alpha-2-HS-glycoprotein and hemopexin: Implications for small molecule compound-mediated neuroprotection

S. Hadano, J. Ikeda, Kazunori Tanaka, 2017, PloS one.

Central nervous system specific high molecular weight ALS2/alsin homophilic complex is enriched in mouse brain synaptosomes.

S. Hadano, Shun Mitsui, A. Otomo, 2022, Biochemical and biophysical research communications.

ALS2, the small GTPase Rab17-interacting protein, regulates maturation and sorting of Rab17-associated endosomes.

S. Hadano, M. Fukuda, Shun Mitsui, 2020, Biochemical and biophysical research communications.

Generation of high-density DNA markers from yeast artificial chromosome DNA by single unique primer-polymerase chain reaction.

H. Lehrach, S. Hadano, J. Ikeda, 1993, Genetic analysis, techniques and applications.

Genomic organization of the human caspase-9 gene on Chromosome 1p36.1-p36.3

M. Hayden, S. Hadano, J. Ikeda, 1999, Mammalian Genome.

A novel tandem repeat sequence located on human chromosome 4p: isolation and characterization.

S. Hadano, C. Lefèvre, J. Ikeda, 1997, Genomics.

EFFECT OF THE DIFFERENCE OF EXERCISE INTENSITY ON THE CHANGES IN AMMONIA AND OXYPURINES

S. Hadano, A. Ito, S. Ikawa, 1988 .

An open-type microdevice to improve the quality of fluorescence labeling for axonal transport analysis in neurons

H. Kimura, S. Hadano, S. Yokoyama, 2019, Biomicrofluidics.

Free Radical Biology and Medicine

S. Hadano, J. Ikeda, Kazunori Tanaka, 2012 .

Functional links between SQSTM1 and ALS2 in the pathogenesis of ALS: cumulative impact on the protection against mutant SOD1-mediated motor dysfunction in mice.

H. Shang, S. Hadano, Masayuki Yamamoto, 2016, Human molecular genetics.

Journal Pre-proof a protective factor of SOD1-linked motor neuron disease, regulates the accumulation and distribution of ubiquitinated protein aggregates in neuron

S. Hadano, E. Warabi, Shun Mitsui, 2022 .

A dopamine receptor antagonist L-745,870 suppresses microglia activation in spinal cord and mitigates the progression in ALS model mice

Y. Itoyama, S. Hadano, J. Ikeda, 2008, Experimental Neurology.