K. Altmann

K. Altmann, 2009, Fortschritte der Chemie organischer Naturstoffe = Progress in the chemistry of organic natural products. Progres dans la chimie des substances organiques naturelles.

The biology and medicinal chemistry of epothilones.

K. Altmann, M. Wartmann, 2012, Current medicinal chemistry. Anti-cancer agents.

Synergistic immunomopharmacological effects of N-alkylamides in Echinacea purpurea herbal extracts.

K. Altmann, J. Gertsch, F. Pellati, 2009, International immunopharmacology.

Small molecule inhibitors provide insights into the relevance of LAT1 and LAT2 in materno‐foetal amino acid transport

K. Altmann, C. Albrecht, J. Gertsch, 2020, Journal of cellular and molecular medicine.

Identification of serotonin 5-HT1A receptor partial agonists in ginger.

K. Altmann, J. Gertsch, A. Nievergelt, 2010, Bioorganic & medicinal chemistry.

High affinity and covalent-binding microtubule stabilizing agents show activity in chemotherapy-resistant acute myeloid leukemia cells.

K. Altmann, M. Moore, S. Ambati, 2015, Cancer letters.

Deorphaning the Macromolecular Targets of the Natural Anticancer Compound Doliculide.

G. Schneider, P. Schneider, D. Reker, 2016, Angewandte Chemie.

Dual Recognition of Double-Stranded DNA by 2'-Aminoethoxy-Modified Oligonucleotides.

F. Natt, K. Altmann, R. Wolf, 1998, Angewandte Chemie.

New anilinophthalazines as potent and orally well absorbed inhibitors of the VEGF receptor tyrosine kinases useful as antagonists of tumor-driven angiogenesis.

G. Martiny-Baron, K. Altmann, R. Cozens, 2000, Journal of medicinal chemistry.

Peptide-Membrane Interaction between Targeting and Lysis.

G. Schneider, P. Wrede, S. Wessler, 2017, ACS chemical biology.

Methods for studying microtubule binding site interactions: zampanolide as a covalent binding agent.

K. Altmann, J. Díaz, J. Miller, 2013, Methods in cell biology.

The epothilones : an outstanding family of anti-tumor agents : from soil to the clinic

K. Altmann, 2009 .

Ring-Closing Metathesis Approaches towards the Total Synthesis of Rhizoxins

K. Altmann, Marc Liniger, C. Neuhaus, 2020, Molecules.

The Chemistry and Biology of Epothilones—The Wheel Keeps Turning

K. Nicolaou, K. Altmann, B. Pfeiffer, 2007, ChemMedChem.

Epothilones and related structures--a new class of microtubule inhibitors with potent in vivo antitumor activity.

K. Altmann, T. O'reilly, M. Wartmann, 2000, Biochimica et biophysica acta.

FUNCTIONALIZED POLYETHYLENE GLYCOLS AND POLYPEPTIDES IN ORGANIC-SYNTHESIS AND CATALYSIS

M. Mutter, K. Altmann, H. Gehrhardt, 1987 .

On the Importance of the Thiazole Nitrogen in Epothilones: Semisynthesis and Microtubule-Binding Affinity of Deaza-Epothilone C

K. Altmann, J. Díaz, J. Estévez-Gallego, 2020, Chemistry.

Synthesis, Microtubule-Binding Affinity, and Antiproliferative Activity of New Epothilone Analogs and of an EGFR-Targeted Epothilone-Peptide Conjugate

K. Altmann, M. Redondo-Horcajo, I. Barasoain, 2019, International journal of molecular sciences.

Synthesis, Biological Profiling and Determination of the Tubulin-Bound Conformation of 12-Aza-Epothilones (Azathilones)

A. Jantsch, K. Altmann, J. Gertsch, 2016, Molecules.

The Impact of Cyclopropane Configuration on the Biological Activity of Cyclopropyl‐Epothilones

K. Altmann, M. Redondo-Horcajo, I. Barasoain, 2014, ChemMedChem.

Diversity through semisynthesis: the chemistry and biological activity of semisynthetic epothilone derivatives

K. Altmann, F. Gaugaz, Raphael Schiess, 2011, Molecular Diversity.

Epothilone analogues with benzimidazole and quinoline side chains: chemical synthesis, antiproliferative activity, and interactions with tubulin.

K. Altmann, J. Díaz, J. Gertsch, 2009, Chemistry.

Synthesis and SAR of C12-C13-oxazoline derivatives of epothilone A.

K. Altmann, J. Gertsch, B. Pfeiffer, 2009, Bioorganic & medicinal chemistry letters.

Epothilones – A fascinating family of microtubule stabilizing antitumor agents

K. Altmann, R. Müller, J. Mulzer, 2008 .

Structure–Activity Relationships in Side‐Chain‐Modified Epothilone Analogues—How Important is the Position of the Nitrogen Atom?

K. Altmann, G. Bold, G. Caravatti, 2006, ChemMedChem.

Patupilone (epothilone B, EPO906) inhibits growth and metastasis of experimental prostate tumors in vivo

K. Altmann, T. O'reilly, F. Wenger, 2005, The Prostate.

Total Synthesis and Biological Evaluation of a C(10)/C(12)‐Phenylene‐Bridged Analog of Epothilone D

P. Furet, K. Altmann, M. Wartmann, 2004, Chemistry & biodiversity.

The merger of natural product synthesis and medicinal chemistry: on the chemistry and chemical biology of epothilones.

K. Altmann, 2004, Organic & biomolecular chemistry.

4. The natural products epothilones A and B as lead structures for anticancer drug discovery: chemistry, biology, and SAR studies.

K. Altmann, T. O'reilly, M. Wartmann, 2004, Progress in medicinal chemistry.

Epothilones and their analogues - a new class of promising microtubule inhibitors

K. Altmann, A. Flörsheimer, 2001 .

Chemical synthesis and biological properties of pyridine epothilones.

D. Zaharevitz, K. Nicolaou, K. Altmann, 2000, Chemistry & biology.

Pharmacological characterization of actin-binding (-)-doliculide.

A. Vollmar, K. Altmann, Tao Chen, 2014, Bioorganic & medicinal chemistry.

Chemical probes to potently and selectively inhibit endocannabinoid cellular reuptake

H. Schiöth, K. Altmann, B. Lutz, 2017, Proceedings of the National Academy of Sciences.

SECOND GENERATION ANTISENSE OLIGONUCLEOTIDES : INHIBITION OF PKC-ALPHA AND C-RAF KINASE EXPRESSION BY CHIMERIC OLIGONUCLEOTIDES INCORPORATING 6'-SUBS TITUTED CARBOCYCLIC NUCLEOSIDES AND 2'-O-ETHYLENE GLYCOL SUBSTITUTED RIBONU CLEOSIDES

K. Altmann, N. Dean, Pierre Martin, 1997 .

Stereoselective synthesis of a monocyclic peloruside a analogue.

K. Altmann, J. Gertsch, C. Wullschleger, 2010, Organic letters.

Ginger Phenylpropanoids Inhibit IL-1β and Prostanoid Secretion and Disrupt Arachidonate-Phospholipid Remodeling by Targeting Phospholipases A2

K. Altmann, J. Gertsch, A. Nievergelt, 2011, The Journal of Immunology.

A Multicenter, Randomized, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Long-Acting Injectable Formulation of Vanoxerine (Vanoxerine Consta 394.2 mg) for Cocaine Relapse Prevention

O. Kallioniemi, K. Altmann, H. Möhler, 2019, World Journal of Neuroscience.

Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter

K. Altmann, Qiang Zhou, J. Gertsch, 2021, Cell discovery.

Synthesis and biological evaluation of epothilone A dimeric compounds.

K. Altmann, D. Passarella, A. Quesada, 2009, Bioorganic & medicinal chemistry.

DUPLEX- AND TRIPLEX-FORMING PROPERTIES OF 4′-THIO-MODIFIED OLIGODEOXYNUCLEOTIDES

R. T. Walker, K. Altmann, D. Hüsken, 1997 .

Polyamide based nucleic acid analogs : Synthesis of δ-amino acids with nucleic acid bases bearing side chains

K. Altmann, C. García-echeverría, C. S. Chiesi, 1997 .

Synthesis and Biological Evaluation of Endocannabinoid Uptake Inhibitors Derived from WOBE437

K. Altmann, J. Gertsch, Simon Nicolussi, 2020, ChemMedChem.

Design, synthesis, and biological properties of highly potent epothilone B analogues.

K. Nicolaou, K. Altmann, P. Giannakakou, 2003, Angewandte Chemie.

An Antigen Capture Assay for the Detection of Mycolactone, the Polyketide Toxin of Mycobacterium ulcerans

K. Altmann, G. Pluschke, M. Gehringer, 2021, The Journal of Immunology.

Actin-binding doliculide causes premature senescence in p53 wild type cells.

A. Vollmar, K. Altmann, Tao Chen, 2016, Bioorganic & medicinal chemistry.

Ammonia uptake by transmembrane pH gradient poly(isoprene)-block-poly(ethylene glycol) polymersomes.

K. Altmann, J. Leroux, Yinyin Bao, 2020, Soft matter.

Discovery of novel CB2 receptor ligands by a pharmacophore-based virtual screening workflow.

Thierry Langer, Daniela Schuster, Gerhard Wolber, 2009, Journal of medicinal chemistry.

Recent developments in natural product-based drug discovery for tuberculosis.

K. Altmann, B. Pfeiffer, Maryline Dong, 2017, Drug discovery today.

Recent developments in the chemical biology of epothilones.

K. Altmann, 2005, Current pharmaceutical design.

Chemical modulation of microtubule structure through the laulimalide/peloruside site.

M. Steinmetz, K. Altmann, F. Gago, 2022, Structure.

Rv2466c mediates the activation of TP053 to kill replicating and non-replicating Mycobacterium tuberculosis.

R. Glockshuber, S. Cole, K. Altmann, 2014, ACS chemical biology.

The chemistry and biology of mycolactones

K. Altmann, M. Gehringer, 2017, Beilstein journal of organic chemistry.

Sequence-specific antitumor activity of a phosphorothioate oligodeoxyribonucleotide targeted to human C-raf kinase supports an antisense mechanism of action in vivo.

E. Lesnik, S. Freier, D. Fabbro, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Beta-caryophyllene is a dietary cannabinoid

Xiang-Qun Xie, Andreas Zimmer, Karl-Heinz Altmann, 2008, Proceedings of the National Academy of Sciences.

Aza-Claisen Rearrangement: Synthesis of 5′-branched 5′-aminothymidines†

K. Altmann, D. Belluš, J. Ammenn, 1997 .

Identification of a new chemical class of potent angiogenesis inhibitors based on conformational considerations and database searching.

P. Furet, K. Altmann, F. Hofmann, 2003, Bioorganic & medicinal chemistry letters.

Chemical synthesis and biological evaluation of cis- and trans-12,13-cyclopropyl and 12,13-cyclobutyl epothilones and related pyridine side chain analogues.

A. Ritzén, K. Nicolaou, K. Altmann, 2001, Journal of the American Chemical Society.

1′,6′-methano carbocyclic thymidine: Synthesis, x-ray crystal structure, and effect on nucleic acid duplex stability

K. Altmann, R. Imwinkelried, G. Rihs, 1994 .

4′,6′-Methano carbocyclic thymidine: A conformationally constrained building block for oligonucleotides

K. Altmann, E. Francotte, G. Rihs, 1994 .

Aza‐Claisen Rearrangement: Synthesis of 5′‐Branched 5′‐Aminothymidines.

K. Altmann, D. Belluš, J. Ammenn, 1997 .

Single-Centre Model for the Active Site of α-Chymotrypsin

M. Mutter, K. Altmann, T. Vorherr, 1986 .

Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents

M. Steinmetz, K. Altmann, J. Díaz, 2013, Science.

Zampanolide, a potent new microtubule-stabilizing agent, covalently reacts with the taxane luminal site in tubulin α,β-heterodimers and microtubules.

K. Altmann, I. Barasoain, J. Díaz, 2012, Chemistry & biology.

Helix‐coil stability constants for the naturally occurring amino acids in water. XXIII. Proline parameters from random poly(hydroxybutylglutamine‐CO‐L‐proline)

H. Scheraga, M. Vásquez, K. Altmann, 1990, Biopolymers.

Synthesis of Peptides Containing (S)‐α‐Methylserine

M. Mutter, E. Altmann, K. Altmann, 1988 .

Synthesis and antimycobacterial activity of 2,1'-dihydropyridomycins.

S. Cole, K. Altmann, R. Hartkoorn, 2013, ACS medicinal chemistry letters.

Total synthesis and configurational assignment of the marine natural product haliclamide.

Luzi J. Barandun, K. Altmann, J. Gertsch, 2013, The Journal of organic chemistry.

Studies toward the Total Synthesis of the Marine Macrolide Salarin C.

K. Altmann, Raffael Schrof, 2018, Organic letters.

Total synthesis of hygrolines and pseudohygrolines.

K. Altmann, Marc Liniger, Katja Estermann, 2013, The Journal of organic chemistry.

Total synthesis of the tubulin inhibitor WF-1360F based on macrocycle formation through ring-closing alkyne metathesis.

K. Altmann, M. Stieger, Marc Liniger, 2013, Angewandte Chemie.

6′-Carbon-substituted carbocyclic analogs of 2′-deoxyribonucleosides — Synthesis and effect on DNA/RNA duplex stability

K. Altmann, U. Pieles, R. Kesselring, 1996 .

Synthesis of (-)-dactylolide and 13-desmethylene-(-)-dactylolide and their effects on tubulin.

K. Altmann, J. Gertsch, Didier Zurwerra, 2010, Organic letters.

Total synthesis of the bacterial RNA polymerase inhibitor ripostatin B.

K. Altmann, F. Glaus, 2012, Angewandte Chemie.

Semisynthetic derivatives of epothilones.

K. Altmann, 2009, Fortschritte der Chemie organischer Naturstoffe = Progress in the chemistry of organic natural products. Progres dans la chimie des substances organiques naturelles.

Protein design: template-assembled synthetic proteins.

M. Mutter, K. Altmann, R. I. Carey, 1991, Ciba Foundation symposium.

Synthesis, Profiling, and Bioactive Conformation of trans ‐Cyclopropyl Epothilones

K. Altmann, M. Redondo-Horcajo, J. Díaz, 2019, Helvetica Chimica Acta.

Making Epothilones Fluoresce: Design, Synthesis, and Biological Characterization of a Fluorescent N12‐Aza‐Epothilone (Azathilone)

K. Altmann, B. Pfeiffer, Jürg Gertsch , 2009, Chembiochem : a European journal of chemical biology.

Synthesis of 12-aza analogs of epothilones and (E)-9,10-dehydroepothilones

A. Jantsch, K. Altmann, B. Pfeiffer, 2008 .

Diastereoselective titanium enolate aldol reaction for the total synthesis of epothilones.

A. Jantsch, K. Altmann, O. Loiseleur, 2002, Organic letters.

Chemical synthesis and biological evaluation of novel epothilone B and trans-12,13-cyclopropyl epothilone B analogues

A. Ritzén, K. Nicolaou, K. Altmann, 2002 .

Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands

M. Steinmetz, K. Altmann, A. Prota, 2019, International journal of molecular sciences.

Synthesis and hybridization properties of polyamide based nucleic acid analogues incorporating pyrrolidine-derived nucleoamino acids.

K. Altmann, C. García-echeverría, B. Cuenoud, 2000, Bioorganic & medicinal chemistry letters.

Sequence dependence of secondary‐structure formation part IV Helix‐forming potential of amphiphilic oligopeptides containing aib residues

M. Mutter, K. Altmann, A. Flörsheimer, 1986 .

Synthesis and biological activity of 7,8,9-trideoxy- and 7R desTHP-peloruside A.

K. Altmann, J. Gertsch, C. Wullschleger, 2013, Chemistry.

Synthesis of an Azathymidine and Its Incorporation into Oligonucleotides

S. Freier, K. Altmann, U. Pieles, 1994 .

Sequence-dependence of secondary structure formation. II. Effect of nearest neighbour interactions on the β-structure formation of host-guest peptides

M. Mutter, K. Altmann, 2009 .

Pyrrolidine based analogs of 3′-deoxythymidine

K. Altmann, 1993 .

SEQUENCE-DEPENDENCE OF SECONDARY STRUCTURE FORMATION .3. BETA-STRUCTURE FORMING POTENTIAL OF AMPHIPHILIC OLIGOPEPTIDES CONTAINING ALTERNATING L-VAL-L-THR AND L-LEU-L-SER RESIDUES

M. Mutter, K. Altmann, A. Florsheimer, 2009 .

Conformational studies on host-guest peptides containing chiral alpha-methyl-alpha-amino acids. Comparison of the helix-inducing potential of alpha-aminoisobutyric acid, (S)-2-ethylalanine and (S)-2-methylserine.

M. Mutter, E. Altmann, K. Altmann, 2009, International journal of peptide and protein research.

Sequence‐Dependence of secondary structure formation: Conformational studies of host–guest peptides in α‐helix and β‐structure supporting media

C. Toniolo, M. Mutter, K. Altmann, 1985, Biopolymers.

Replacement of the phosphodiester linkage in oligonucleotides by heterocycles: synthesis of thymidine dinucleotide analogs with triazole-modified backbones

K. Altmann, P. Matt, Thomas Lochmann, 1997 .

Anticancer Agents: Frontiers in Cancer Chemotherapy

K. Altmann, I. Ojima, G. Vite, 2001 .

Cover Picture: Evaluation of Novel Epothilone Analogues by means of a Common Pharmacophore and a QSAR Pseudoreceptor Model for Taxanes and Epothilones (ChemMedChem 1/2010)

K. Altmann, M. Botta, F. Manetti, 2010 .

Microtubule-stabilizing agents: a growing class of important anticancer drugs.

K. Altmann, 2001, Current opinion in chemical biology.

Conformational preferences of natural and C3-modified epothilones in aqueous solution.

K. Altmann, J. Gertsch, T. Carlomagno, 2008, Journal of medicinal chemistry.

New tubulin inhibitors from plants - : A critical assessment

K. Altmann, J. Gertsch, Sarah Meier, 2007 .

Replacement of the phosphodiester linkage in oligonucleotides by heterocycles: the effect of triazole- and imidazole-modified backbones on DNA/RNA duplex stability

K. Altmann, P. Matt, 1997 .

RNA polymerase motions during promoter melting

K. Altmann, S. Darst, R. Landick, 2017, Science.

GABAA receptors as in vivo substrate for the anxiolytic action of valerenic acid, a major constituent of valerian root extracts

K. Vogt, K. Altmann, A. Barberis, 2009, Neuropharmacology.

Alkylamides from Echinacea Are a New Class of Cannabinomimetics

Xiang-Qun Xie, Bernard Faller, Karl-Heinz Altmann, 2006, Journal of Biological Chemistry.

Falcarinol is a covalent cannabinoid CB1 receptor antagonist and induces pro-allergic effects in skin.

K. Altmann, J. Gertsch, C. Floris, 2010, Biochemical pharmacology.

Development of an ELISA for the quantification of mycolactone, the cytotoxic macrolide toxin of Mycobacterium ulcerans

K. Altmann, N. Ruggli, G. Pluschke, 2020, PLoS neglected tropical diseases.

A ring-closing metathesis-based approach to the synthesis of (+)-tetrabenazine.

K. Altmann, M. Johannes, 2012, Organic letters.

Structural basis of small-molecule inhibition of human multidrug transporter ABCG2

J. Kowal, H. Stahlberg, K. Altmann, 2018, Nature Structural & Molecular Biology.

Total Synthesis of the Endocannabinoid Uptake Inhibitor Guineensine and SAR Studies

K. Altmann, J. Gertsch, Simon Nicolussi, 2019, ChemMedChem.

Cancer Chemotherapy: Basic Science to the Clinic. By Rachel Airley.

Karl-Heinz Altmann, K. Altmann, 2009 .

Synthesis of an Azathymidine and Its Incorporation into Oligonucleotides.

S. Freier, K. Altmann, U. Pieles, 1995 .

The residence time of the bound water in the hydrophobic minor groove of the carbocyclic-nucleoside analogs of Dickerson-Drew dodecamers.

K. Altmann, M. Egli, J. Chattopadhyaya, 1998, Journal of biomolecular structure & dynamics.

An expeditious synthesis of 3′-α-carboxymethyl-2′-O-methyl ribonucleosides

K. Altmann, R. Kesselring, P. Matt, 1999 .

The evaluation of 2′- and 6′-substituted carbocyclic nucleosides as building blocks for antisense oligonucleotides

K. Altmann, H. Moser, A. D. Mesmaeker, 1995 .

The ups and downs of nucleic acid duplex stability: structure-stability studies on chemically-modified DNA:RNA duplexes.

S. Freier, K. Altmann, S M Freier, 1997, Nucleic acids research.

Studies toward the Synthesis of an Oxazole-Based Analog of (-)-Zampanolide.

K. Altmann, D. Lucena‐Agell, B. Pfeiffer, 2021, Organic Letters.

Correlating structure and stability of DNA duplexes with incorporated 2'-O-modified RNA analogues.

F. Natt, K. Altmann, M. Egli, 1998, Biochemistry.

The effects of 2′- and 3′-alkyl substituents on oligonucleotide hybridization and stability

K. Altmann, A. D. Mesmaeker, C. Schmit, 1994 .

Antisense- and antigene-based drug design strategies in oncology

D. Fabbro, K. Altmann, T. Geiger, 1998 .

STUDIES OF A CHEMICALLY MODIFIED OLIGODEOXYNUCLEOTIDE CONTAINING A 5-ATOM AMIDE BACKBONE WHICH EXHIBITS IMPROVED BINDING TO RNA

F. Natt, K. Altmann, M. Egli, 2001, Nucleosides, Nucleotides & Nucleic Acids.

Crystal Structures of Oligodeoxyribonucleotides Containing 6'-alpha-Methyl and 6'-alpha-Hydroxy Carbocyclic Thymidines

K. Altmann, M. Egli, S. Portmann, 1996 .

The Synthesis of 1′-Methyl Carbocyclic Thymidine and its Effect on Nucleic Acid Duplex Stability

K. Altmann, R. Kesselring, 1994 .

2′-deoxyribo-PNAs: A structurally novel class of polyamide nucleic acids with good RNA and DNA binding affinity

K. Altmann, U. Pieles, A. D. Mesmaeker, 1999 .

RNA-Binding affinities and crystal structure of oligonucleotides containing five-atom amide-based backbone structures.

K. Altmann, M. Egli, C. Wilds, 2006, Biochemistry.

Confromational Studies on Peptides Containing Enantiometric α-Methyl α-Amino Acids. Part I. Differential conformational properties of (R)- and (S)-2-methylaspartic acid

M. Mutter, E. Altmann, K. Altmann, 1992 .

Directed hydrogenations and an Ireland-Claisen rearrangement linked to evans-tishchenko chemistry: the highly efficient total synthesis of the marine cyclodepsipeptide doliculide.

K. Altmann, Tao Chen, 2015, Chemistry.

Arylvinylpiperazine Amides, a New Class of Potent Inhibitors Targeting QcrB of Mycobacterium tuberculosis

S. Cole, K. Altmann, A. Steyn, 2018, mBio.

Clinical studies with epothilones.

K. Altmann, 2009, Fortschritte der Chemie organischer Naturstoffe = Progress in the chemistry of organic natural products. Progres dans la chimie des substances organiques naturelles.

Synthesis and biological evaluation of highly potent analogues of epothilones B and D.

K. Altmann, G. Bold, G. Caravatti, 2000, Bioorganic & medicinal chemistry letters.

Structural basis of small-molecule inhibition of human multidrug transporter ABCG2

J. Kowal, H. Stahlberg, K. Altmann, 2018, Nature Structural & Molecular Biology.

Antibody-Mediated Neutralization of the Exotoxin Mycolactone, the Main Virulence Factor Produced by Mycobacterium ulcerans

Jun Li, Karl-Heinz Altmann, K. Altmann, 2016, PLoS neglected tropical diseases.

Zampanolide Binding to Tubulin Indicates Cross-Talk of Taxane Site with Colchicine and Nucleotide Sites.

K. Altmann, J. Miller, A. Prota, 2017, Journal of natural products.

Primary resistance mechanism of the canine distemper virus fusion protein against a small-molecule membrane fusion inhibitor.

R. Plemper, D. Fotiadis, K. Altmann, 2019, Virus research.

Fragment-Based De Novo Design Reveals a Small-Molecule Inhibitor of Helicobacter Pylori HtrA.

G. Schneider, S. Wessler, Tiago Rodrigues, 2015, Angewandte Chemie.

Taxanes convert regions of perturbed microtubule growth into rescue sites

M. Steinmetz, K. Altmann, J. Díaz, 2019, Nature Materials.

A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin

M. Steinmetz, K. Altmann, D. Lucena‐Agell, 2018, Nature Communications.

A Method for the Stereoselective Construction of the Hemiaminal Center in Zampanolides.

K. Altmann, J. Díaz, T. Brütsch, 2020, Organic letters.

Epothilones as lead structures for new anticancer drugs--pharmacology, fermentation, and structure-activity-relationships.

K. Altmann, K. Memmert, 2008, Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques.

Structural insight into the stabilization of microtubules by taxanes

M. Steinmetz, K. Altmann, F. Gago, 2022, bioRxiv.

Zampanolide, a Microtubule-Stabilizing Agent, Is Active in Resistant Cancer Cells and Inhibits Cell Migration

K. Altmann, J. Miller, P. Northcote, 2017, International journal of molecular sciences.

The Total Synthesis and Biological Assessment of trans‐Epothilone A

K. Altmann, G. Bold, G. Caravatti, 2002 .

New Natural Noncannabinoid Ligands for Cannabinoid Type-2 (CB2) Receptors

K. Altmann, J. Gertsch, Stefan Raduner, 2006, Journal of receptor and signal transduction research.

Configurationally Stabilized Analogs of M. ulcerans Exotoxins Mycolactones A and B Reveal the Importance of Side Chain Geometry for Mycolactone Virulence.

K. Altmann, B. Pfeiffer, G. Pluschke, 2019, Organic letters.

The Construction of New Proteins. Part III. Artificial folding units by assembly of amphiphilic secondary structures on a template

M. Mutter, E. Altmann, K. Altmann, 1988 .

Helix‐coil stability constants for the naturally occurring amino acids in water. XXIV. Half‐cystine parameters from random poly(hydroxybutylglutamine‐CO‐S‐methylthio‐L‐cysteine)

H. Scheraga, K. Altmann, J. Wójcik, 1990 .

A general strategy for the de novo design of proteins--template assembled synthetic proteins.

M. Mutter, K. Altmann, 1990, The International journal of biochemistry.

Patupilone (epothilone B, EPO906) and imatinib (STI571, Glivec) in combination display enhanced antitumour activity in vivo against experimental rat C6 glioma

K. Altmann, S. Ferretti, E. Buchdunger, 2005, Cancer Chemotherapy and Pharmacology.

Molecular recognition of epothilones by microtubules and tubulin dimers revealed by biochemical and NMR approaches.

K. Altmann, F. Gago, T. Carlomagno, 2014, ACS chemical biology.

Efficacy and Tolerability of Long-Acting Injectable Formulation of Nalmefene (Nalmefene Consta 393.1 mg) for Opioid Relapse Prevention: A Multicentre, Open-Label, Randomised Controlled Trial

O. Kallioniemi, K. Altmann, H. Möhler, 2019, World Journal of Neuroscience.

Self-assembling cannabinomimetics: supramolecular structures of N-alkyl amides.

R. Abagyan, K. Altmann, J. Gertsch, 2007, Journal of natural products.

Mycobacterial Toxin Induces Analgesia in Buruli Ulcer by Targeting the Angiotensin Pathways

Daniel Henrion, Karl-Heinz Altmann, Edouard Yeramian, 2014, Cell.

Approaches to synthetic vaccines: design of epitope-containing amphiphilic peptides matching the antigenic structure in the native protein

M. Mutter, K. Altmann, S. Vuilleumier, 1986 .

Natural products as leads for anticancer drug discovery: discovery of new chemotypes of microtubule stabilizers through reengineering of the epothilone scaffold.

K. Altmann, J. Gertsch, M. Wartmann, 2010, Chimia.

Pyridomycin bridges the NADH- and substrate-binding pockets of the enoyl reductase InhA.

Karl-Heinz Altmann, S. Cole, K. Altmann, 2014, Nature chemical biology.

Structure-Activity Relationship Studies on the Macrolide Exotoxin Mycolactone of Mycobacterium ulcerans

Jun Li, Karl-Heinz Altmann, K. Altmann, 2013, PLoS neglected tropical diseases.

Template-Assembled Synthetic Proteins with 4-Helix-Bundle Topology - Total Chemical Synthesis and Conformational Studies

D. Wyss, M. Mutter, K. Altmann, 1992 .

Multidimensional Design of Anticancer Peptides.

Petra Schneider, Gisbert Schneider, Jan A Hiss, 2015, Angewandte Chemie.

Epothilone B and its analogs - a new family of anticancer agents.

K. Altmann, 2003, Mini reviews in medicinal chemistry.

Synthesis and Biological Evaluation of C(13)/C(13′)‐Bis(desmethyl)disorazole Z

K. Altmann, D. Lucena‐Agell, M. A. Oliva, 2022, Angewandte Chemie.

The Chemistry and Biology of Epothilones—Lead Structures for the Discovery of Improved Microtubule Inhibitors

K. Altmann, 2006 .

The State of the Art of Chemical Biology

G. Schneider, F. Diederich, S. Schreiber, 2009, Chembiochem : a European journal of chemical biology.

Total Synthesis of 26-Fluoro-epothilone B

K. Altmann, O. Loiseleur, G. Koch, 2004 .

Switch peptides : medium induced alpha-helix to beta-sheet transitions of bis-amphiphilic secondary structures and their membrane activity

M. Mutter, K. Altmann, R. Gassmann, 1992 .

The LAT1 inhibitor JPH203 reduces growth of thyroid carcinoma in a fully immunocompetent mouse model

K. Altmann, J. Gertsch, M. Dettmer, 2018, Journal of experimental & clinical cancer research : CR.

Crystal structures of taxane-tubulin complexes: Implications for the mechanism of microtubule stabilization by Taxol

M. Steinmetz, K. Altmann, D. Lucena‐Agell, 2021 .

A Collection of Robust Organic Synthesis Reactions for In Silico Molecule Design

Markus Hartenfeller, Gisbert Schneider, Edgar Jacoby, 2011, J. Chem. Inf. Model..

Probing the Bioactivity-Relevant Chemical Space of Robust Reactions and Common Molecular Building Blocks

Markus Hartenfeller, Gisbert Schneider, Edgar Jacoby, 2012, J. Chem. Inf. Model..

Structural basis of microtubule stabilization by laulimalide and peloruside A.

M. Steinmetz, K. Altmann, J. Díaz, 2014, Angewandte Chemie.

Epothilones as Lead Structures for the Synthesis-Based Discovery of New Chemotypes for Microtubule Stabilization

K. Altmann, J. Gertsch, M. Wartmann, 2008 .

Design and synthesis of 12-aza-epothilones (azathilones)--"non-natural" natural products with potent anticancer activity.

K. Altmann, J. Gertsch, M. Wartmann, 2006, Angewandte Chemie.

Total Synthesis and Biological Assessment of Benzimidazole‐Based Analogues of Epothilone A: Ambivalent Effects on Cancer Cell Growth Inhibition

K. Altmann, M. Wartmann, Frédéric Cachoux, 2006, Chembiochem : a European journal of chemical biology.

Natural product-based drug discovery: Epothilones as lead structures for the discovery of new anticancer agents

K. Altmann, Andreas Flörsheimera, Guido Bolda, 2004 .

The high-resolution solution structure of epothilone A bound to tubulin: an understanding of the structure-activity relationships for a powerful class of antitumor agents.

Jens Meiler, Christian Griesinger, Wolfgang Jahnke, 2003, Angewandte Chemie.

Total synthesis and biological assessment of cyclopropane-based epothilone analogues : Modulation of drug efflux through polarity adjustments

K. Altmann, M. Wartmann, Frédéric Cachoux, 2006 .

Evaluation of Novel Epothilone Analogues by means of a Common Pharmacophore and a QSAR Pseudoreceptor Model for Taxanes and Epothilones

K. Altmann, M. Botta, F. Manetti, 2010, ChemMedChem.

The Binding Mode of Side Chain‐ and C3‐Modified Epothilones to Tubulin

A. Navarro‐Vázquez, K. Altmann, J. Díaz, 2010, ChemMedChem.

Synthesis and Biological Activity of 12-Aza-Epothilones (Azathilones) - Non-Natural Natural Products with Potent Antiproliferative Activity

K. Altmann, J. Gertsch, M. Wartmann, 2007 .

Synthetic and Semisynthetic Analogs of Epothilones: Chemistry and Biological Activity

K. Nicolaou, K. Altmann, G. Caravatti, 2001 .

Total Synthesis of the Resorcylic Lactone-Based Kinase Inhibitor L-783277

K. Altmann, T. Hofmann, 2008 .

Polyamide Based Nucleic Acid Analogues - Synthesis of δ-Amino Acids with Nucleic Acid Bases Bearing Side Chains.

K. Altmann, C. García-echeverría, C. S. Chiesi, 1997 .

Preclinical pharmacological profile of ABJ879, a novel epothilone B analog with potent and protracted anti-tumor activity

K. Altmann, T. O'reilly, M. Wartmann, 2004 .

A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin

M. Steinmetz, K. Altmann, D. Lucena‐Agell, 2018, Nature Communications.

Resorcylic Acid Lactone L-783,277 Inhibits the Growth of the Human Adrenal Cancer Cell Line H295R in Vitro

K. Altmann, P. Sicińska, M. Kowalewicz-Kulbat, 2009, International journal of immunopathology and pharmacology.

Total Synthesis and Biological Assessment of Mandelalide A.

K. Altmann, T. Brütsch, P. Bucher, 2016, Chemistry.

Total Synthesis and Biological Assessment of Mandelalide A (I).

K. Altmann, P. Bucher, Tobias Michael Bruetsch, 2016 .

Total synthesis of the marine diterpenoid blumiolide C.

K. Altmann, J. Gertsch, W. Schweizer, 2008, Angewandte Chemie.

Novel polyamide based nucleic acid analogs-synthesis of oligomers and RNA-binding properties

K. Altmann, C. García-echeverría, D. Hüsken, 1997 .

In Vitro and In Vivo Evaluation of ABCG2 (BCRP) Inhibitors Derived from Ko143.

K. Altmann, S. Krämer, L. Mu, 2023, Journal of medicinal chemistry.

Local structure in ribonuclease A. Effect of amino acid substitutions on the preferential formation of the native disulfide loop in synthetic peptides corresponding to residues Cys58-Cys72 of bovine pancreatic ribonuclease A

H. Scheraga, K. Altmann, 1990 .

An RCM-Based Total Synthesis of the Antibiotic Disciformycin B.

K. Altmann, P. Waser, 2020, Angewandte Chemie.

Strategies for the de novo design of proteins

M. Mutter, K. Altmann, G. Tuchscherer, 1988 .

Maytansinol Derivatives: Side Reactions as a Chance for New Tubulin Binders

K. Altmann, D. Lucena‐Agell, F. Vasile, 2021, Chemistry.

Anticancer Drugs from Nature—Natural Products as a Unique Source of New Microtubule‐Stabilizing Agents

Karl-Heinz Altmann, K. Altmann, J. Gertsch, 2007 .

De novo design of proteins. Template-assembled synthetic proteins (TASP).

M. Mutter, K. Altmann, G. Tuchscherer, 1994, Methods in molecular biology.

The LAT1 inhibitor JPH203 reduces growth of thyroid carcinoma in a fully immunocompetent mouse model

K. Altmann, J. Gertsch, M. Dettmer, 2018, Journal of Experimental & Clinical Cancer Research.

Rv2466c mediates the activation of TP053 to kill replicating and non-replicating Mycobacterium tuberculosis.

R. Glockshuber, S. Cole, K. Altmann, 2014, ACS chemical biology.

Ginger Phenylpropanoids Inhibit IL-1β and Prostanoid Secretion and Disrupt Arachidonate-Phospholipid Remodeling by Targeting Phospholipases A2

K. Altmann, J. Gertsch, A. Nievergelt, 2011, The Journal of Immunology.

Deorphaning the Macromolecular Targets of the Natural Anticancer Compound Doliculide.

G. Schneider, P. Schneider, D. Reker, 2016, Angewandte Chemie.

Mycobacterial Toxin Induces Analgesia in Buruli Ulcer by Targeting the Angiotensin Pathways

E. Yeramian, K. Altmann, V. Paillé, 2014, Cell.

Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter

K. Altmann, J. Gertsch, R. Yan, 2021, Cell Discovery.

Total synthesis of hypermodified epothilone analogs with potent in vitro antitumor activity.

K. Altmann, J. Gertsch, M. Wartmann, 2008, Organic letters.

Pyridomycin bridges the NADH- and substrate-binding pockets of the enoyl reductase InhA.

S. Cole, K. Altmann, H. Gingell, 2014, Nature chemical biology.

The Binding Mode of Side Chain‐ and C3‐Modified Epothilones to Tubulin

A. Navarro‐Vázquez, K. Altmann, J. Díaz, 2010, ChemMedChem.

Epothilone analogues with benzimidazole and quinoline side chains: chemical synthesis, antiproliferative activity, and interactions with tubulin.

K. Altmann, J. Díaz, J. Gertsch, 2009, Chemistry.

Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents

M. Steinmetz, K. Altmann, J. Díaz, 2013, Science.

Multidimensional Design of Anticancer Peptides.

G. Schneider, P. Schneider, K. Altmann, 2015, Angewandte Chemie.

Structure, Function and Pharmacology of SLC7 Family Members and Homologues.

D. Fotiadis, K. Altmann, C. Albrecht, 2022, Chimia.

Synthesis and Biological Evaluation of Furano‐Epothilone C.

K. Altmann, M. Wartmann, D. Schinzer, 2004 .

New anilinophthalazines as potent and orally well absorbed inhibitors of the VEGF receptor tyrosine kinases useful as antagonists of tumor-driven angiogenesis

Stover, Roth, J. Mestan, 2000, Journal of medicinal chemistry.

The chemistry of disorazoles and structure-activity relationships: An update

K. Altmann, C. Bold, 2024, Tetrahedron.

A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin

M. Steinmetz, K. Altmann, D. Lucena‐Agell, 2018, Nature Communications.