S. Zographos

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POTENT INHIBITION OF GLYCOGEN PHOSPHORYLASE BY A SPIROHYDANTOIN OF GLUCOPYRANOSE : FIRST PYRANOSE ANALOGUES OF HYDANTOCIDIN

L. Johnson, C. Bichard, E. Mitchell, 1995 .

Effects of commonly used cryoprotectants on glycogen phosphorylase activity and structure

L. Johnson, K. Watson, S. Zographos, 1999, Protein science : a publication of the Protein Society.

New inhibitors of glycogen phosphorylase as potential antidiabetic agents.

S. Zographos, N. Oikonomakos, D. Leonidas, 2008, Current medicinal chemistry.

Glucose-based spiro-isoxazolines: a new family of potent glycogen phosphorylase inhibitors.

S. Zographos, N. Oikonomakos, D. Leonidas, 2009, Bioorganic & medicinal chemistry.

The σ‐Hole Phenomenon of Halogen Atoms Forms the Structural Basis of the Strong Inhibitory Potency of C5 Halogen Substituted Glucopyranosyl Nucleosides towards Glycogen Phosphorylase b

S. Zographos, D. Leonidas, A. Psarra, 2012, ChemMedChem.

Indirubin and indigo analogues as potential inhibitors of glycogenolysis: structural basis of glycogen phosphorylase inhibition

S. Zographos, N. Oikonomakos, D. Leonidas, 2006 .

Crystallographic and computational studies on 4‐phenyl‐N‐(β‐D‐glucopyranosyl)‐1H‐1,2,3‐triazole‐1‐acetamide, an inhibitor of glycogen phosphorylase: Comparison with α‐D‐glucose, N‐acetyl‐β‐D‐glucopyranosylamine and N‐benzoyl‐N′‐β‐D‐glucopyranosyl urea binding

S. Zographos, N. Oikonomakos, D. Leonidas, 2007 .

Identification of novel bioinspired synthetic mosquito repellents by combined ligand-based screening and OBP-structure-based molecular docking.

S. Zographos, T. Thireou, E. Eliopoulos, 2018, Insect biochemistry and molecular biology.

Characterization of hCINAP, a Novel Coilin-interacting Protein Encoded by a Transcript from the Transcription Factor TAFIID32 Locus*

A. Lamond, S. Zographos, S. Ogg, 2005, Journal of Biological Chemistry.

The architecture of hydrogen and sulfur σ-hole interactions explain differences in the inhibitory potency of C-β-d-glucopyranosyl thiazoles, imidazoles and an N-β-d glucopyranosyl tetrazole for human liver glycogen phosphorylase and offer new insights to structure-based design.

S. Zographos, D. Leonidas, A. Psarra, 2019, Bioorganic & medicinal chemistry.

Amide-1,2,3-triazole bioisosterism: the glycogen phosphorylase case

S. Zographos, N. Oikonomakos, D. Leonidas, 2009 .

The design of potential antidiabetic drugs: experimental investigation of a number of β-D-glucose analogue inhibitors of glycogen phosphorylase

L. Johnson, C. Bichard, E. Mitchell, 1994, European Journal of Drug Metabolism and Pharmacokinetics.

Effects of commonly used cryoprotectants on glycogen phosphorylase activity and structure

L. Johnson, K. Watson, S. Zographos, 1999, Protein science : a publication of the Protein Society.

Glucopyranosylidene-spiro-imidazolinones, a New Ring System: Synthesis and Evaluation as Glycogen Phosphorylase Inhibitors by Enzyme Kinetics and X-ray Crystallography.

S. Zographos, D. Leonidas, A. Psarra, 2019, Journal of medicinal chemistry.

Essential oil-in-water microemulsions for topical application: structural study, cytotoxic effect and insect repelling activity

S. Zographos, V. Papadimitriou, F. Nallet, 2022, Colloids and Surfaces A: Physicochemical and Engineering Aspects.

Triazole carboxylic acids as anionic sugar mimics? Inhibition of glycogen phosphorylase by a d-glucotriazole carboxylate

L. Pickering, S. Zographos, N. Oikonomakos, 1997 .

The crystal structure of the AgamOBP1•Icaridin complex reveals alternative binding modes and stereo-selective repellent recognition

S. Zographos, D. Fessas, C. Potamitis, 2016, Cellular and Molecular Life Sciences.

Crystal and Solution Studies of the “Plus-C” Odorant-binding Protein 48 from Anopheles gambiae

S. Zographos, T. Thireou, D. Fessas, 2013, The Journal of Biological Chemistry.

Glucose analogue inhibitors of glycogen phosphorylase: from crystallographic analysis to drug prediction using GRID force-field and GOLPE variable selection.

L. Johnson, C. Bichard, E. Mitchell, 1995, Acta crystallographica. Section D, Biological crystallography.

The binding of β-d-glucopyranosyl-thiosemicarbazone derivatives to glycogen phosphorylase: A new class of inhibitors.

S. Zographos, N. Oikonomakos, D. Leonidas, 2010, Bioorganic & medicinal chemistry.

Allosteric inhibition of glycogen phosphorylase a by the potential antidiabetic drug 3‐isopropyl 4‐(2‐chlorophenyl)‐1,4‐dihydro‐1‐ethyl‐2‐methyl‐pyridine‐3,5,6‐tricarboxylate

S. Zographos, N. Oikonomakos, K. Tsitsanou, 1999, Protein science : a publication of the Protein Society.

A galactopyranose analogue of hydantocidin

R. Dwek, M. Wormald, S. Zographos, 1996 .

The binding of C5-alkynyl and alkylfurano[2,3-d]pyrimidine glucopyranonucleosides to glycogen phosphorylase b: synthesis, biochemical and biological assessment.

S. Zographos, D. Leonidas, A. Psarra, 2012, European journal of medicinal chemistry.

1-(3-Deoxy-3-fluoro-beta-d-glucopyranosyl) pyrimidine derivatives as inhibitors of glycogen phosphorylase b: Kinetic, crystallographic and modelling studies.

S. Zographos, D. Leonidas, V. G. Tsirkone, 2010, Bioorganic & medicinal chemistry.

The binding of 2-deoxy-D-glucose 6-phosphate to glycogen phosphorylase b: kinetic and crystallographic studies.

L. Johnson, S. Zographos, N. Oikonomakos, 1995, Journal of molecular biology.

Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.

S. Zographos, N. Oikonomakos, D. Leonidas, 2008, Journal of medicinal chemistry.

Anopheles gambiae odorant binding protein crystal complex with the synthetic repellent DEET: implications for structure-based design of novel mosquito repellents

S. Zographos, T. Thireou, D. Leonidas, 2011, Cellular and Molecular Life Sciences.

Iminosugars as potential inhibitors of glycogenolysis: structural insights into the molecular basis of glycogen phosphorylase inhibition.

S. Zographos, N. Oikonomakos, D. Leonidas, 2006, Journal of medicinal chemistry.

Nanomolar Inhibitors of Glycogen Phosphorylase Based on β-d-Glucosaminyl Heterocycles: A Combined Synthetic, Enzyme Kinetic, and Protein Crystallography Study.

S. Zographos, D. Leonidas, G. Stravodimos, 2017, Journal of medicinal chemistry.

Cooperative Interactions of the Catalytic Nucleophile and the Catalytic Acid in the Inhibition of β-Glycosidases. Calculations and their validation by comparative kinetic and structural studies of the inhibition of glycogen phosphorylase b

Spyros E. Zographos, Katerina E. Tsitsanou, S. Zographos, 1998 .

Kinetic and crystallographic studies of glucopyranose spirohydantoin and glucopyranosylamine analogs inhibitors of glycogen phosphorylase

Georgios Archontis, Evangelia D Chrysina, K. Watson, 2005, Proteins.

Crystallographic studies on two bioisosteric analogues, N-acetyl-beta-D-glucopyranosylamine and N-trifluoroacetyl-beta-D-glucopyranosylamine, potent inhibitors of muscle glycogen phosphorylase.

Evangelia D Chrysina, S. Zographos, N. Oikonomakos, 2005, Bioorganic & medicinal chemistry.

Mapping the ribonucleolytic active site of bovine seminal ribonuclease. The binding of pyrimidinyl phosphonucleotide inhibitors.

S. Zographos, D. Leonidas, J. Matoušek, 2009, European journal of medicinal chemistry.

N-(4-Substituted-benzoyl)-N'-(β-d-glucopyranosyl)ureas as inhibitors of glycogen phosphorylase: Synthesis and evaluation by kinetic, crystallographic, and molecular modelling methods.

S. Zographos, N. Oikonomakos, D. Leonidas, 2012, Bioorganic & Medicinal Chemistry.

Structural basis for the carbohydrate recognition of the Sclerotium rolfsii lectin.

S. Zographos, N. Oikonomakos, D. Leonidas, 2007, Journal of molecular biology.

SWAPPING THREE-DIMENSIONAL DOMAIN BINDING SPECIFICITY THROUGH : CONTROL OF Anopheles gambiae from ' ' Plus-C ' ' Odorant-binding Protein 48 Crystal and Solution Studies of the Protein Structure and Folding :

S. Zographos, T. Thireou, D. Fessas, 2013 .

Flavopiridol Inhibits Glycogen Phosphorylase by Binding at the Inhibitor Site*

Spyros E. Zographos, Katerina E. Tsitsanou, L. Johnson, 2000, The Journal of Biological Chemistry.

Behavioural response of Culex pipiens biotype molestus to oviposition pheromone.

S. Zographos, D. Papachristos, A. Michaelakis, 2022, Journal of insect physiology.

[Simple screw fixation for calcaneal fractures: 60 cases with preoperative computed tomography analysis].

S. Zographos, B. Chaminade, G. Utheza, 2000, Revue de chirurgie orthopedique et reparatrice de l'appareil moteur.

Specific inhibition of glycogen phosphorylase by a spirodiketopiperazine at the anomeric position of glucopyranose

L. Johnson, K. Watson, S. Zographos, 1995 .

Differential expression of molecular motors in the motor cortex of sporadic ALS

Michael W. Pfaffl, Carsten W. Lederer, Spyros E. Zographos, 2007, Neurobiology of Disease.

Sourcing the affinity of flavonoids for the glycogen phosphorylase inhibitor site via crystallography, kinetics and QM/MM-PBSA binding studies: comparison of chrysin and flavopiridol.

S. Zographos, N. Oikonomakos, D. Leonidas, 2013, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Activator anion binding site in pyridoxal phosphorylase b: The binding of phosphite, phosphate, and fluorophosphate in the crystal

L. Johnson, S. Zographos, N. Oikonomakos, 1996, Protein science : a publication of the Protein Society.

[3-dimensional imaging of thalamic fractures of the calcaneum. Validation of classifying fractures into 3 forms].

S. Zographos, P. Chiron, B. Chaminade, 1998, Revue de chirurgie orthopédique et réparatrice de l'appareil moteur.

[Double measurement of the Böhler angle: prognostic value of radiological angles in posterior facet fractures of the calcaneus].

S. Zographos, B. Chaminade, G. Utheza, 2001, Revue de chirurgie orthopédique et réparatrice de l'appareil moteur.

The structure of AgamOBP5 in complex with the natural insect repellents Carvacrol and Thymol: Crystallographic, fluorescence and thermodynamic binding studies.

S. Zographos, D. Fessas, D. Leonidas, 2023, International journal of biological macromolecules.

A Combined Computational Methodology for the Discovery of Hit Compounds with Putative Insect Repellency Properties

S. Zographos, P. Zoumpoulakis, K. Tsitsanou, 2022, ChemMedChem.

Glycogen phosphorylase revisited: extending the resolution of the R- and T-state structures of the free enzyme and in complex with allosteric activators.

S. Zographos, D. Leonidas, K. Tsitsanou, 2021, Acta crystallographica. Section F, Structural biology communications.

High Consistency of Structure-Based Design and X-Ray Crystallography: Design, Synthesis, Kinetic Evaluation and Crystallographic Binding Mode Determination of Biphenyl-N-acyl-β-d-Glucopyranosylamines as Glycogen Phosphorylase Inhibitors

S. Zographos, D. Leonidas, A. Tsagkarakou, 2019, Molecules.

Kinetics, in silico docking, molecular dynamics, and MM‐GBSA binding studies on prototype indirubins, KT5720, and staurosporine as phosphorylase kinase ATP‐binding site inhibitors: The role of water molecules examined

Georgios Archontis, S. Zographos, N. Oikonomakos, 2011, Proteins.

hCINAP is an atypical mammalian nuclear adenylate kinase with an ATPase motif: Structural and functional studies

A. Lamond, S. Zographos, N. Oikonomakos, 2012, Proteins.

Binding of N‐acetyl‐N ′‐β‐d‐glucopyranosyl urea and N‐benzoyl‐N ′‐β‐d‐glucopyranosyl urea to glycogen phosphorylase b

B. Tóth, S. Zographos, N. Oikonomakos, 2002 .

Binding of N-acetyl-N '-beta-D-glucopyranosyl urea and N-benzoyl-N '-beta-D-glucopyranosyl urea to glycogen phosphorylase b: kinetic and crystallographic studies.

B. Tóth, S. Zographos, N. Oikonomakos, 2002, European journal of biochemistry.

The structure of glycogen phosphorylase b with an alkyldihydropyridine-dicarboxylic acid compound, a novel and potent inhibitor.

L. Johnson, K. Watson, S. Zographos, 1997, Structure.

Experimental study of the subtalar joint axis preliminary investigation

S. Zographos, M. Hobatho, B. Chaminade, 2001, Surgical and Radiologic Anatomy.

The binding of 3'-N-piperidine-4-carboxyl-3'-deoxy-ara-uridine to ribonuclease A in the crystal.

S. Zographos, N. Oikonomakos, D. Leonidas, 2006, Bioorganic & medicinal chemistry.

Glucopyranosylidene-spiro-iminothiazolidinone, a new bicyclic ring system: synthesis, derivatization, and evaluation for inhibition of glycogen phosphorylase by enzyme kinetic and crystallographic methods.

S. Zographos, D. Leonidas, K. Kövér, 2014, Bioorganic & medicinal chemistry.

The 1.76 A resolution crystal structure of glycogen phosphorylase B complexed with glucose, and CP320626, a potential antidiabetic drug.

S. Zographos, N. Oikonomakos, G. Archontis, 2002, Bioorganic & medicinal chemistry.

Influence of pH on indole-dependent heterodimeric interactions between Anopheles gambiae odorant-binding proteins OBP1 and OBP4.

S. Zographos, R. Sowdhamini, D. Fessas, 2023, International journal of biological macromolecules.

N‐acetyl‐β‐D‐glucopyranosylamine: A potent T‐state inhibitor of glycogen phosphorylase. A comparison with α‐D‐glucose

L. Johnson, C. Bichard, K. Watson, 1995, Protein science : a publication of the Protein Society.

Halogen-substituted (C-β-D-glucopyranosyl)-hydroquinone regioisomers: synthesis, enzymatic evaluation and their binding to glycogen phosphorylase.

S. Zographos, N. Oikonomakos, D. Leonidas, 2011, Bioorganic & medicinal chemistry.

Glycogen phosphorylase inhibitors: A free energy perturbation analysis of glucopyranose spirohydantoin analogues

S. Zographos, N. Oikonomakos, G. Archontis, 2005, Proteins.

The σ‐Hole Phenomenon of Halogen Atoms Forms the Structural Basis of the Strong Inhibitory Potency of C5 Halogen Substituted Glucopyranosyl Nucleosides towards Glycogen Phosphorylase b

S. Zographos, D. Leonidas, A. Psarra, 2012, ChemMedChem.

Structure based inhibitor design targeting glycogen phosphorylase B. Virtual screening, synthesis, biochemical and biological assessment of novel N-acyl-β-d-glucopyranosylamines.

Georgios Archontis, Loranne Agius, S. Zographos, 2014, Bioorganic & medicinal chemistry.

Differential expression of molecular motors in the motor cortex of sporadic ALS

S. Zographos, M. Pfaffl, C. Lederer, 2007, Neurobiology of Disease.

Crystallographic Studies on α- and β-D-glucopyranosyl Formamide Analogues, Inhibitors of Glycogen Phosphorylase

Spyros E. Zographos, S. Zographos, N. Oikonomakos, 2003 .

Morpholino, piperidino, and pyrrolidino derivatives of pyrimidine nucleosides as inhibitors of ribonuclease A: synthesis, biochemical, and crystallographic evaluation.

S. Zographos, N. Oikonomakos, D. Leonidas, 2009, Journal of medicinal chemistry.

FR258900, a potential anti‐hyperglycemic drug, binds at the allosteric site of glycogen phosphorylase

S. Zographos, N. Oikonomakos, D. Leonidas, 2007, Protein science : a publication of the Protein Society.