C. Arrowsmith

发表

M. Gerstein, G. Montelione, A. Edwards, 2003, Science.

Global analysis of protein folding using massively parallel design, synthesis, and testing

D. Baker, Alex Ford, V. Mulligan, 2017, Science.

Epigenetic protein families: a new frontier for drug discovery

C. Bountra, C. Arrowsmith, P. Fish, 2012, Nature Reviews Drug Discovery.

An NMR approach to structural proteomics

D. Wishart, A. Edwards, Gregory M Lee, 2002, Proceedings of the National Academy of Sciences of the United States of America.

NMR data collection and analysis protocol for high-throughput protein structure determination.

Gaohua Liu, G. Montelione, T. Szyperski, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Single-stranded DNA mimicry in the p53 transactivation domain interaction with replication protein A

C. Arrowsmith, A. Pineda-Lucena, J. Liao, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Assignment of 1HN, 15N, 13Cα, 13CO and 13Cβ resonances in a 67 kDa p53 dimer using 4D-TROSY NMR spectroscopy

L. Kay, C. Arrowsmith, F. Mulder, 2000 .

New insights into p53 function from structural studies.

C. Arrowsmith, P. Morin, 1996, Oncogene.

Refined solution structures of the Escherichia coli trp holo- and aporepressor.

O Jardetzky, O. Jardetzky, C. Arrowsmith, 1993, Journal of molecular biology.

Molecular recognition of p53 and MDM2 by USP7/HAUSP

Shili Duan, Cheryl H Arrowsmith, Tianne Wu, 2006, Nature Structural &Molecular Biology.

Characterization of the oligomerization defects of two p53 mutants found in families with Li–Fraumeni and Li–Fraumeni-like syndrome

T. Davison, C. Arrowsmith, C. Kay, 1998, Oncogene.

Solution structure and dynamics of yeast elongin C in complex with a von Hippel-Lindau peptide.

D. Case, A. Edwards, C. Arrowsmith, 2001, Journal of molecular biology.

Structural characterization of a flexible two-domain protein in solution using small angle X-ray scattering and NMR data.

J. Prestegard, Yun-Xing Wang, C. Arrowsmith, 2014, Structure.

Epigenetic switch-induced viral mimicry evasion in chemotherapy resistant breast cancer.

B. Haibe-Kains, D. Cescon, M. Lupien, 2020, Cancer discovery.

Metabolic adaptations underlie epigenetic vulnerabilities in chemoresistant breast cancer

Benjamin Haibe-Kains, D. Cescon, M. Lupien, 2018, bioRxiv.

Structure of Escherichia coli ribose-5-phosphate isomerase: a ubiquitous enzyme of the pentose phosphate pathway and the Calvin cycle.

Cheryl H Arrowsmith, Steven Beasley, Andrzej Joachimiak, 2003, Structure.

Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family

A. Gingras, T. Pawson, S. Knapp, 2012, Cell.

Human HDAC7 Harbors a Class IIa Histone Deacetylase-specific Zinc Binding Motif and Cryptic Deacetylase Activity*

J. Min, C. Arrowsmith, M. Schapira, 2008, Journal of Biological Chemistry.

Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors.

S. Frye, F. Liu, C. Arrowsmith, 2013, Journal of medicinal chemistry.

Consistent blind protein structure generation from NMR chemical shift data

Oliver F. Lange, D. Baker, Gaohua Liu, 2008, Proceedings of the National Academy of Sciences.

Simultaneous prediction of protein folding and docking at high resolution

D. Baker, I. André, Rhiju Das, 2009, Proceedings of the National Academy of Sciences.

Assessment of a method to characterize antibody selectivity and specificity for use in immunoprecipitation

Jeffrey R. Whiteaker, Ben C. Collins, Jacob J. Kennedy, 2015, Nature Methods.

Screening for Inhibitors of Low-Affinity Epigenetic Peptide-Protein Interactions: An AlphaScreen™-Based Assay for Antagonists of Methyl-Lysine Binding Proteins

Tim J. Wigle, S. Frye, W. Janzen, 2010, Journal of biomolecular screening.

Structural proteomics: toward high-throughput structural biology as a tool in functional genomics.

A. Edwards, C. Arrowsmith, A. Yee, 2003, Accounts of chemical research.

Protein production and purification

K. Gunsalus, G. Montelione, J. Bray, 2008, Nature Methods.

Structural proteomics: a tool for genome annotation.

A. Edwards, C. Arrowsmith, A. Yee, 2004, Current opinion in chemical biology.

Crystal Structure Of Human Potassium Channel Kv Beta-subunit (KCNAB2)

A. Edwards, K. Kavanagh, C. Arrowsmith, 2005 .

Solution structure of the hypothetical protein Mth677 from Methanobacterium thermoautotrophicum: A novel α+β fold

A. Valencia, D. Devos, A. Ortiz, 2004, Protein science : a publication of the Protein Society.

Tackling reproducibility in academic preclinical drug discovery

Michelle R. Arkin, Marcie A. Glicksman, P. Jeffrey Conn, 2015, Nature Reviews Drug Discovery.

A structure-based model of the c-Myc/Bin1 protein interaction shows alternative splicing of Bin1 and c-Myc phosphorylation are key binding determinants.

Thomas Szyperski, Antonio Pineda-Lucena, Cheryl H Arrowsmith, 2005, Journal of molecular biology.

Recognition and Specificity Determinants of the Human Cbx Chromodomains*

Shili Duan, Matthieu Schapira, Cheryl H. Arrowsmith, 2010, The Journal of Biological Chemistry.

A chemical biology toolbox to study protein methyltransferases and epigenetic signaling

Jian Jin, Matthieu Schapira, Jennifer A. Ward, 2019, Nature Communications.

Hypothetical protein AF2241 from Archaeoglobus fulgidus adopts a cyclophilin-like fold

S. Li, Lei Li, C. Arrowsmith, 2007, Journal of biomolecular NMR.

Backbone and side chain 1H, 13C, and 15N resonance assignments of AF2241 from Archaeoglobus fulgidus

S. Li, C. Arrowsmith, A. Yee, 2007, Journal of biomolecular NMR.

Structural proteomics: prospects for high throughput sample preparation.

M Gerstein, M. Gerstein, Y. Kluger, 2000, Progress in biophysics and molecular biology.

Solution NMR structure of the HLTF HIRAN domain: a conserved module in SWI2/SNF2 DNA damage tolerance proteins

C. Arrowsmith, D. Korzhnev, D. Neculai, 2016, Journal of biomolecular NMR.

Solution structure of ribosomal protein S28E from Methanobacterium thermoautotrophicum

Bin Wu, Weontae Lee, Antonio Pineda-Lucena, 2003, Protein science : a publication of the Protein Society.

PRMT5 inhibition disrupts splicing and stemness in glioblastoma

Gary D Bader, Trevor J Pugh, M. Tyers, 2021, Nature Communications.

A novel strategy for NMR resonance assignment and protein structure determination

Cheryl H. Arrowsmith, Alexander Lemak, Maria Sunnerhagen, 2011, Journal of biomolecular NMR.

Chemical shift changes provide evidence for overlapping single-stranded DNA- and XPA-binding sites on the 70 kDa subunit of human replication protein A.

C. Arrowsmith, G. W. Buchko, M. Kennedy, 2003, Nucleic acids research.

Crystal structure of Methanobacterium thermoautotrophicum conserved protein MTH1020 reveals an NTN‐hydrolase fold

Cheryl H Arrowsmith, Anders Thygesen, A. Edwards, 2002, Proteins.

Structural genomics and drug discovery: all in the family.

Matthieu Schapira, Cheryl H Arrowsmith, Linda D B McBroom-Cerajewski, 2008, Current opinion in chemical biology.

Structural Biology of Human H3K9 Methyltransferases

Valérie Campagna-Slater, Matthieu Schapira, Abdellah Allali-Hassani, 2010, PloS one.

Characterization of segments from the central region of BRCA1: an intrinsically disordered scaffold for multiple protein-protein and protein-DNA interactions?

Cheryl H Arrowsmith, C. Arrowsmith, J. Liao, 2005, Journal of molecular biology.

Optimization of resolution and sensitivity of 4D NOESY using Multi-dimensional Decomposition

V. Orekhov, C. Arrowsmith, A. Yee, 2005, Journal of biomolecular NMR.

A Suite of Triple Resonance NMR Experiments for the Backbone Assignment of 15N, 13C, 2H Labeled Proteins with High Sensitivity

Weontae Lee, Cheryl H. Arrowsmith, Toshio Yamazaki, 1994 .

Assignment of 15N, 13Cα, 13Cβ, and HN Resonances in an 15N,13C,2H Labeled 64 kDa Trp Repressor−Operator Complex Using Triple-Resonance NMR Spectroscopy and 2H-Decoupling

L. Kay, K. Gardner, C. Arrowsmith, 1996 .

Solution NMR in structural genomics.

Cheryl H Arrowsmith, Aleksandras Gutmanas, C. Arrowsmith, 2006, Current opinion in structural biology.

Integrating Structure, Bioinformatics, and Enzymology to Discover Function

J. Thornton, R. Laskowski, A. Edwards, 2003, Journal of Biological Chemistry.

Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1).

G. Poda, C. Arrowsmith, M. Schapira, 2016, Journal of medicinal chemistry.

A chemical toolbox for the study of bromodomains and epigenetic signaling

Shili Duan, Mathieu Lupien, Stefan Knapp, 2018, bioRxiv.

Structure-based functional classification of hypothetical protein MTH538 from Methanobacterium thermoautotrophicum.

A. Edwards, C. Arrowsmith, A. Yee, 2000, Journal of molecular biology.

The Shwachman-Bodian-Diamond Syndrome Protein Family Is Involved in RNA Metabolism*

T. Hughes, J. Rommens, N. Krogan, 2005, Journal of Biological Chemistry.

X‐ray crystal structure of MTH938 from Methanobacterium thermoautotrophicum at 2.2 Å resolution reveals a novel tertiary protein fold

G. Montelione, E. Arnold, C. Arrowsmith, 2001, Proteins.

A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion

L. Qin, L. Mazutis, J. Min, 2019, eLife.

Discovery of small molecule antagonists of the USP5 zinc finger ubiquitin-binding domain

C. Arrowsmith, S. Houliston, M. Schapira, 2019, bioRxiv.

Structural and Functional Comparison of the RING Domains of Two p53 E3 Ligases, Mdm2 and Pirh2*

B. Raught, C. Arrowsmith, Y. Sheng, 2010, The Journal of Biological Chemistry.

ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells.

Gary D Bader, M. Bernstein, M. Lupien, 2017, Cell stem cell.

Preferential binding of IFI16 protein to cruciform structure and superhelical DNA.

C. Arrowsmith, J. Liao, J. Coufal, 2012, Biochemical and biophysical research communications.

Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP.

Xi-Ping Huang, B. Roth, S. Frye, 2013, Journal of medicinal chemistry.

A cellular chemical probe targeting the chromodomains of Polycomb Repressive Complex 1

Nancy Cheng, Su Qin, Bradley M Dickson, 2015, Nature chemical biology.

Targeting non-bromodomain chromatin readers

C. Arrowsmith, M. Schapira, 2019, Nature Structural & Molecular Biology.

Discovery of a chemical probe for the L3MBTL3 methyl-lysine reader domain

A. Emili, J. Greenblatt, Xi-Ping Huang, 2012, Nature chemical biology.

Structural and Functional Characterization of DUF1471 Domains of Salmonella Proteins SrfN, YdgH/SssB, and YahO

Michael D. Daily, Meagan C. Burnet, G. Montelione, 2014, PloS one.

GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer

B. Haibe-Kains, D. Cescon, M. Lupien, 2019, Nature Communications.

Hemi-methylated DNA regulates DNA methylation inheritance through allosteric activation of H3 ubiquitylation by UHRF1

B. Kuhlman, B. Strahl, C. Arrowsmith, 2016, eLife.

Discovery of the SMYD3 Inhibitor BAY-6035 Using Thermal Shift Assay (TSA)-Based High-Throughput Screening

Clara D. Christ, C. Arrowsmith, A. Haegebarth, 2021, SLAS discovery : advancing life sciences R & D.

Abstract A44: Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer

P. Khatri, P. Hainaut, J. Sage, 2016 .

An Integrative Proteomic Approach Identifies Novel Cellular SMYD2 Substrates.

C. Arrowsmith, M. Schapira, Shili Duan, 2016, Journal of proteome research.

Mammary molecular portraits reveal lineage-specific features and progenitor cell vulnerabilities

Gary D Bader, Swneke D. Bailey, P. Boutros, 2018, The Journal of cell biology.

Discovery of a chemical probe for PRDM9

E. Guccione, C. Arrowsmith, M. Schapira, 2019, Nature Communications.

The Human Epha3 Receptor Tyrosine Kinase and Juxtamembrane Region

A. Edwards, F. Mackenzie, C. Arrowsmith, 2006 .

A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases.

Kyle V. Butler, C. Arrowsmith, M. Schapira, 2016, ACS chemical biology.

Structure of human Ubiquitin-conjugating enzyme E2 G1

A. Edwards, F. Mackenzie, C. Arrowsmith, 2005 .

Structure of human CDC2-like kinase 2 (CLK2)

S. Knapp, A. Edwards, O. Fedorov, 2010 .

Alternative splicing and allosteric regulation modulate the chromatin binding of UHRF1

Alaguraj Veluchamy, C. Arrowsmith, S. Houliston, 2020, Nucleic acids research.

PRMT inhibition induces a viral mimicry response in triple-negative breast cancer

B. Haibe-Kains, K. Massirer, D. Cescon, 2022, Nature Chemical Biology.

RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors.

Grant W. Brown, A. Antoniou, G. Chenevix-Trench, 2021, The Journal of clinical investigation.

Selective, small molecule co-factor binding site inhibition of a Su(var)3-9, Enhancer of Zeste, Trithorax (SET) domain containing lysine methyltransferase.

C. Arrowsmith, M. Schapira, R. Ferreira de Freitas, 2019, Journal of medicinal chemistry.

Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas.

Dylan M. Marchione, B. Garcia, M. McConechy, 2019, Cancer cell.

Chemical Biology Approaches for Characterization of Epigenetic Regulators.

C. Arrowsmith, P. Prinos, M. Szewczyk, 2016, Methods in enzymology.

Epigenetic chemical probes to identify therapeutic targets in oncology

C. Arrowsmith, E. Lima-Fernandes, D. Barsyte-Lovejoy, 2015 .

1.3 Efficient Strategies for Production of Eukaryotic Proteins

C. Arrowsmith, J. Cossar, 2012 .

Metabotropic glutamate receptor mGluR1 complexed with LY341495 antagonist

C. Bountra, C. Arrowsmith, J. Weigelt, 2009 .

NMR structure and binding studies confirm that PA4608 from Pseudomonas aeruginosa is a PilZ domain and a c‐di‐GMP binding protein

C. Arrowsmith, A. Yee, A. Semesi, 2006, Proteins.

Fluorescence-Based Methods for Screening Writers and Readers of Histone Methyl Marks

C. Arrowsmith, M. Vedadi, A. Allali-Hassani, 2012, Journal of biomolecular screening.

A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells.

Peter A. DiMaggio, Tim J. Wigle, B. Garcia, 2011, Nature chemical biology.

Diverse modes of galacto-specific carbohydrate recognition by a family 31 glycoside hydrolase from Clostridium perfringens

C. Arrowsmith, S. Houliston, A. Boraston, 2017, PloS one.

Segmental differences in the stability of thetrp-repressor peptide backbone

O. Jardetzky, C. Arrowsmith, J. Czaplicki, 1991, Journal of biomolecular NMR.

A novel member of the split βαβ fold: Solution structure of the hypothetical protein YML108W from Saccharomyces cerevisiae

C. Arrowsmith, A. Yee, A. Pineda-Lucena, 2003, Protein science : a publication of the Protein Society.

Discovery of small molecule antagonists of human Retinoblastoma Binding Protein 4 (RBBP4)

G. Poda, C. Arrowsmith, M. Schapira, 2021, bioRxiv.

Structure and activity of human TMPRSS2 protease implicated in SARS-CoV-2 activation

S. Subramaniam, C. Arrowsmith, A. Hutchinson, 2022, Nature Chemical Biology.

Discovery of a First-in-class Protein Arginine Methyltransferase 6 (PRMT6) Covalent Inhibitor.

C. Arrowsmith, M. Vedadi, M. Szewczyk, 2020, Journal of medicinal chemistry.

Identification of lysine isobutyrylation as a new histone modification mark

C. Arrowsmith, Yingming Zhao, Y. G. Zheng, 2020, bioRxiv.

A Chemical Probe For Tudor Domain Protein Spin1 to Investigate Chromatin Functions

O. Fedorov, C. Bountra, C. Arrowsmith, 2019 .

HMCES Functions in the Alternative End-Joining Pathway of the DNA DSB Repair during Class Switch Recombination in B Cells.

L. Aravind, C. Arrowsmith, A. Rao, 2019, Molecular cell.

Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3

Julian E. Fuchs, O. Fedorov, C. Arrowsmith, 2019, Nature Chemical Biology.

Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress responses

Amber L. Couzens, M. Tyers, A. Gingras, 2018, bioRxiv.

Revealing the Protein Propionylation Activity of the Histone Acetyltransferase Males absent on the first (MOF)

C. Arrowsmith, Yingming Zhao, Y. G. Zheng, 2018 .

Solution structure of TA0895, a MoaD homologue from Thermoplasma acidophilum

C. Arrowsmith, A. Yee, Weontae Lee, 2006, Proteins.

PRMT inhibition induces a viral mimicry response in triple-negative breast cancer

B. Haibe-Kains, K. Massirer, D. Cescon, 2022, Nature Chemical Biology.

RAS and PP2A activities converge on epigenetic gene regulation

M. Nykter, C. Arrowsmith, M. Schapira, 2022, bioRxiv.

A meanfield approach to the thermodynamics of a protein-solvent system with application to the oligomerization of the tumor suppressor p53.

T. Davison, J. Noolandi, C. Arrowsmith, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Arginine methylation of FOXP3 is crucial for the suppressive function of regulatory T cells.

C. Arrowsmith, Chung-Hsi Wang, Tingxi Guo, 2019, Journal of autoimmunity.

PRMT5 regulates ATF4 transcript splicing and oxidative stress response

M. Minden, M. Lupien, C. Arrowsmith, 2022, bioRxiv.

Functional interdependence of BRD4 and DOT1L in MLL leukemia

Andrew J. Bannister, P. Grandi, G. Drewes, 2016, Nature Structural &Molecular Biology.

Structure and activity of human TMPRSS2 protease implicated in SARS-CoV-2 activation

S. Subramaniam, F. Bénard, C. Arrowsmith, 2022, Nature Chemical Biology.

Combinatorial Anticancer Drug Screen Identifies Off-Target Effects of Epigenetic Chemical Probes.

C. Arrowsmith, M. Schapira, A. Schimmer, 2022, ACS chemical biology.

A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3).

Xi-Ping Huang, B. Roth, P. Atadja, 2015, Angewandte Chemie.

Ubiquitin-conjugating enzyme E2-25 kDa (Huntington interacting protein 2)

Alexey Bochkarev, Cheryl H. Arrowsmith, Aled M. Edwards, 2005 .

Abstract PR03: Multivalent histone engagement by the linked tandem Tudor and PHD domains of UHRF1 is required for DNA methylation maintenance

B. Strahl, C. Arrowsmith, S. Houliston, 2013 .

Protein Interaction Domains of the Ubiquitin-specific Protease, USP7/HAUSP*

C. Arrowsmith, Y. Sheng, L. Frappier, 2003, Journal of Biological Chemistry.

Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein-Barr nuclear antigen 1 implications for EBV-mediated immortalization.

C. Arrowsmith, J. Liao, Weontae Lee, 2005, Molecular cell.

Identification of Rpl29 as a major substrate of the lysine methyltransferase Set7/9

A. Singh, C. Arrowsmith, A. Guo, 2018, The Journal of Biological Chemistry.

Protein Aggregates Are Recruited to Aggresome by Histone Deacetylase 6 via Unanchored Ubiquitin C Termini

H. Ouyang, F. Mackenzie, C. Arrowsmith, 2011, The Journal of Biological Chemistry.

Crystal structure of human CUL3 N-terminal domain bound to KEAP1 BTB and 3-box

C. Bountra, C. Arrowsmith, A. Bullock, 2017 .

Secretion and circular dichroism analysis of the C-terminal signal peptides of HlyA and LktA.

C. Arrowsmith, V. Ling, F. Zhang, 1995, Biochemistry.

Inter-comparison of salt effect correction for δ18O and δ2H measurements in seawater by CRDS and IRMS using the gas-H2O equilibration method

C. Arrowsmith, M. Leng, G. Aloisi, 2017 .

Recognition of multivalent histone states associated with heterochromatin by UHRF 1

Yun-Xing Wang, F. Chédin, C. Arrowsmith, 2011 .

Three-dimensional solution structure of lactoferricin B, an antimicrobial peptide derived from bovine lactoferrin.

H. Vogel, C. Arrowsmith, P. Hwang, 1998, Biochemistry.

The solution structure of the protein ydhA from Escherichia coli

C. Arrowsmith, A. Yee, A. Semesi, 2006, Journal of biomolecular NMR.

Structure of Escherichia coli ribose-5-phosphate isomerase, RpiA, complexed with arabinose-5-phosphate.

Sherry L. Mowbray, Cheryl H. Arrowsmith, Aled M. Edwards, 2003 .

PBRM1, SETD2 and BAP1 — the trinity of 3p in clear cell renal cell carcinoma

A. Finelli, C. Arrowsmith, P. Prinos, 2022, Nature Reviews Urology.

Identiﬁcation of lysine isobutyrylation as a new histone modiﬁcation mark

C. Arrowsmith, Yingming Zhao, Y. G. Zheng, 2020 .

A conversation on using chemical probes to study protein function in cells and organisms

C. Arrowsmith, 2022, Nature Communications.

Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3)

P. Atadja, E. Li, F. Liu, 2017, Journal of medicinal chemistry.

An HNCA Pulse Scheme for the Backbone Assignment of 15N,13C,2H-Labeled Proteins: Application to a 37-kDa Trp Repressor-DNA Complex

L. Kay, F. Dahlquist, C. Arrowsmith, 1994 .

Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines.

S. Frye, C. Arrowsmith, M. Vedadi, 2011, Journal of medicinal chemistry.

Structure of the kinase domain of human RIPK2 in complex with ponatinib

C. Bountra, C. Arrowsmith, A. Bullock, 2013 .

Enzymatic nucleosome acetylation selectively affects activity of histone methyltransferases in vitro.

R. Aebersold, C. Arrowsmith, M. Vedadi, 2022, Biochimica et biophysica acta. Gene regulatory mechanisms.

Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2.

Mikkel A. Algire, N. Soni, C. Arrowsmith, 2015, ACS medicinal chemistry letters.

Erratum: A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells (Nature Chemical Biology (2011) 7 (401-404))

Peter A. DiMaggio, Tim J. Wigle, B. Garcia, 2011 .

A First-in-class, Highly Selective and Cell-active Allosteric Inhibitor of Protein Arginine Methyltransferase 6 (PRMT6)

R. Campbell, C. Arrowsmith, M. Schapira, 2020, bioRxiv.

Zinc is required for structural stability of the C‐terminus of archaeal translation initiation factor aIF2β

C. Arrowsmith, P. Gutiérrez, K. Gehring, 2002, FEBS letters.

Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination

P. Nordlund, O. Fedorov, C. Arrowsmith, 2006, Proceedings of the National Academy of Sciences.

A Basic Post-SET Extension of NSDs Is Essential for Nucleosome Binding In Vitro

C. Arrowsmith, M. Schapira, S. Gräslund, 2014, Journal of biomolecular screening.

Small-molecule ligands of methyl-lysine binding proteins: optimization of selectivity for L3MBTL3.

S. Frye, W. Janzen, C. Arrowsmith, 2013, Journal of medicinal chemistry.

Phosphorylation of the DNA repair scaffold SLX4 drives folding of the SAP domain and activation of the MUS81-EME1 endonuclease.

S. Sharpe, C. Arrowsmith, S. Houliston, 2022, Cell reports.

Crystal structure of catalytic domain of human euchromatic histone methyltransferase 1 in complex with SAH and mono-Methylated H3K9 Peptide

J. Min, C. Arrowsmith, A. Bochkarev, 2007 .

Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1

C. Arrowsmith, C. Bronner, Shili Duan, 2008, Nature.

An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1.

K. Hahn, Xi-Ping Huang, B. Roth, 2013, ACS chemical biology.

WDR5 in complex with unmodified H3K4 peptide

J. Min, C. Arrowsmith, J. Weigelt, 2006 .

I: NMR STRUCTURAL ANALYSIS OF THE MINIMAL TRANSCRIPTIONALLY ACTIVE REGION*

C. Arrowsmith, C. Koth, P. Morin, 1998 .

Ring1B contains a ubiquitin-like docking module for interaction with Cbx proteins.

C. Arrowsmith, J. Bacik, Shili Duan, 2009, Biochemistry.

KCMF1 (potassium channel modulatory factor 1) Links RAD6 to UBR4 (ubiquitin N-recognin domain-containing E3 ligase 4) and Lysosome-Mediated Degradation*

B. Raught, C. Arrowsmith, T. Srikumar, 2015, Molecular & Cellular Proteomics.

KCMF 1 links RAD 6 to UBR 4 and lysosome-mediated degradation

B. Raught, C. Arrowsmith, T. Srikumar, 2015 .

Elongation factor TFIIS contains three structural domains: solution structure of domain II.

C. Arrowsmith, P. Morin, D. Awrey, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Quantitative determination of conformational, dynamic, and kinetic parameters of a ligand-protein/DNA complex from a complete relaxation and conformational exchange matrix analysis of intermolecular transferred NOESY.

H. Moseley, C. Arrowsmith, N. Krishna, 1997, Biochemistry.

Abstract B45: Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell and patient-derived tumor organoids

L. Muthuswamy, C. Arrowsmith, S. Gallinger, 2016 .

Assignment of 1H(N), 15N, 13C(alpha), 13CO and 13C(beta) resonances in a 67 kDa p53 dimer using 4D-TROSY NMR spectroscopy.

L. Kay, C. Arrowsmith, F. Mulder, 2000, Journal of biomolecular NMR.

A Semi-automated Organoid Screening Method Demonstrates Epigenetic Control of Intestinal Epithelial Differentiation

C. Arrowsmith, J. V. von Kries, P. Jay, 2021, Frontiers in Cell and Developmental Biology.

Rational Design and Synthesis of Selective PRMT4 Inhibitors: a New Chemotype for Development of Cancer Therapeutics

C. Arrowsmith, M. Vedadi, M. Szewczyk, 2020, bioRxiv.

The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity.

Mikkel A. Algire, K. Comess, Chaohong Sun, 2017, Nature chemical biology.

A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion

L. Qin, L. Mazutis, J. Min, 2019, bioRxiv.

Analysis of binding site similarity, small-molecule similarity and experimental binding profiles in the human cytosolic sulfotransferase family

Janet M. Thornton, Rafael Najmanovich, Richard J. Morris, 2007, Bioinform..

LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity.

Cheryl H Arrowsmith, Peter J Brown, Mary M Mader, 2018, ACS medicinal chemistry letters.

NMR Structure Determination and Structure-Based Functional Characterization of Conserved Hypothetical Protein MTH1175 from Methanobacterium thermoautotrophicum

C. Arrowsmith, A. Yee, J. Cort, 2004, Journal of Structural and Functional Genomics.

The promise and peril of chemical probes.

John P. Overington, Jian Jin, Matthieu Schapira, 2015, Nature chemical biology.

A community resource of experimental data for NMR / X‐ray crystal structure pairs

Rong Xiao, Robert Powers, Thomas Szyperski, 2016, Protein science : a publication of the Protein Society.

The second round of Critical Assessment of Automated Structure Determination of Proteins by NMR: CASD-NMR-2013

Bin Wu, Antonio Rosato, Gaohua Liu, 2015, Journal of biomolecular NMR.

Blind testing of routine, fully automated determination of protein structures from NMR data.

Harald Schwalbe, Bin Wu, David Baker, 2012, Structure.

Unique opportunities for NMR methods in structural genomics

G. Montelione, R. Powers, J. Prestegard, 2009, Journal of Structural and Functional Genomics.

The solution structure of ribosomal protein S17E from Methanobacterium thermoautotrophicum: A structural homolog of the FF domain

G. Montelione, C. Arrowsmith, A. Yee, 2008, Protein science : a publication of the Protein Society.

An integrated platform for automated analysis of protein NMR structures.

Robert Powers, Thomas Szyperski, Gaetano T Montelione, 2005, Methods in enzymology.

Letter to the Editor: Solution structure of hypothetical protein TA1414 from Thermoplasma acidophilum

C. Arrowsmith, A. Yee, D. Monleón, 2004, Journal of biomolecular NMR.

Role for NMR in structural genomics

G. Montelione, J. Markley, C. Arrowsmith, 2004, Journal of Structural and Functional Genomics.

Novel projected 4D triple resonance experiments for polypeptide backbone chemical shift assignment

T. Szyperski, C. Arrowsmith, Youlin Xia, 2002, Journal of biomolecular NMR.

NleG Type 3 Effectors from Enterohaemorrhagic Escherichia coli Are U-Box E3 Ubiquitin Ligases

Cheryl H. Arrowsmith, Alexander Lemak, Bin Wu, 2010, PLoS pathogens.

Zinc-bundle structure of the essential RNA polymerase subunit RPB10 from Methanobacterium thermoautotrophicum.

C. Arrowsmith, L. McIntosh, Cameron D. Mackereth, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Solution structure of the RNA polymerase subunit RPB5 from Methanobacterium thermoautotrophicum.

C. Arrowsmith, A. Yee, A. Dharamsi, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Structure of a Conserved Domain Common to the Transcription Factors TFIIS, Elongin A, and CRSP70*

C. Arrowsmith, C. Koth, C H Arrowsmith, 2000, The Journal of Biological Chemistry.

Yeast Transcript Elongation Factor (TFIIS), Structure and Function

C. Arrowsmith, C. Koth, C. Kane, 1998, The Journal of Biological Chemistry.

Yeast Transcript Elongation Factor (TFIIS), Structure and Function

C. Arrowsmith, C. Koth, P. Morin, 1998, The Journal of Biological Chemistry.

Structure and function in the p53 family

C. Arrowsmith, 1999, Cell Death and Differentiation.

Solution structure of a conserved C‐terminal domain of p73 with structural homology to the SAM domain

C. Arrowsmith, A. Ayed, S. Chi, 1999, The EMBO journal.

Structure-Activity Relationship of USP5 Inhibitors.

C. Arrowsmith, M. Schapira, R. Al-awar, 2021, Journal of medicinal chemistry.

Discovery of small molecule antagonists of the USP5 zinc finger ubiquitin-binding domain.

C. Arrowsmith, S. Houliston, M. Schapira, 2019, Journal of medicinal chemistry.

(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells

Amber L. Couzens, A. Gingras, M. Bunnage, 2014, Proceedings of the National Academy of Sciences.

Erratum: The promise and peril of chemical probes (Nature Chemical Biology (2015) 11 (536-541))

John P. Overington, Jayme L. Dahlin, Christopher M. Austin, 2015 .

The crystal structure of spermidine synthase with a multisubstrate adduct inhibitor

Aled Edwards, Cheryl Arrowsmith, Steven Beasley, 2002, Nature Structural Biology.

Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell– and patient-derived tumor organoids

Gordon Keller, Steven Gallinger, Ming-Sound Tsao, 2015, Nature Medicine.

A correlation between .beta.-hydrogen isotope effects on carbon-13 NMR chemical shifts in unsaturated systems and the strength of hyperconjugative interactions

C. Arrowsmith, A. Kresge, 1986 .

Genome-wide Analysis of Substrate Specificities of the Escherichia coli Haloacid Dehalogenase-like Phosphatase Family*

Liran Carmel, Eugene V Koonin, Hirotada Mori, 2006, Journal of Biological Chemistry.

Discovery of Small-Molecule Antagonists of the H3K9me3 Binding to UHRF1 Tandem Tudor Domain

P. Atadja, E. Li, C. Arrowsmith, 2018, SLAS discovery : advancing life sciences R & D.

TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma

K. Saikatendu, C. Arrowsmith, M. Schapira, 2018, Oncotarget.

Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6.

C. Arrowsmith, M. Schapira, M. Vedadi, 2016, Journal of medicinal chemistry.

Protein arginine methylation: from enigmatic functions to therapeutic targeting

C. Arrowsmith, M. Schapira, D. Barsyte-Lovejoy, 2021, Nature Reviews Drug Discovery.

Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening.

Matthieu Schapira, Cheryl H Arrowsmith, Peter J Brown, 2016, Journal of medicinal chemistry.

Structure of Thermotoga maritima stationary phase survival protein SurE: a novel acid phosphatase.

A. Joachimiak, C. Arrowsmith, J. Katz, 2001, Structure.

Accessibility of different histone H3-binding domains of UHRF1 is allosterically regulated by phosphatidylinositol 5-phosphate.

D. Schwarzer, C. Arrowsmith, S. Houliston, 2014, Molecular cell.

Human steroidogenic acute regulatory protein

P. Nordlund, C. Arrowsmith, J. Weigelt, 2010 .

Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors

Matthieu Schapira, James E. Bradner, John R. Engen, 2012, Nature Communications.

Structural basis of HMCES interactions with abasic DNA and multivalent substrate recognition

L. Aravind, C. Arrowsmith, A. Rao, 2019, Nature Structural & Molecular Biology.

WD40 repeat domain proteins: a novel target class?

Mike Tyers, Matthieu Schapira, Cheryl H. Arrowsmith, 2017, Nature Reviews Drug Discovery.

THE BASE-CATALYZED DECOMPOSITION OF NITRAMIDE : A NEW LOOK AT AN OLD REACTION

C. Arrowsmith, A. Kresge, D. Onwood, 1991 .

The weak interdomain coupling observed in the 70 kDa subunit of human replication protein A is unaffected by ssDNA binding.

C. Arrowsmith, N. Isern, G. Daughdrill, 2001, Nucleic acids research.

LSD1-Mediated Epigenetic Reprogramming Drives CENPE Expression and Prostate Cancer Progression.

T. H. van der Kwast, P. Boutros, A. Zoubeidi, 2017, Cancer research.

Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy

Richard A. Moore, David J. Jörg, Trevor J Pugh, 2017, Nature.

ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells.

Gary D Bader, M. Bernstein, M. Lupien, 2017, Cell stem cell.

MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin.

J. Dick, M. Bernstein, S. Pfister, 2015, Cancer cell.

Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas.

Dylan M. Marchione, B. Garcia, M. McConechy, 2019, Cancer cell.

A global assessment of cancer genomic alterations in epigenetic mechanisms

M. Lupien, C. Arrowsmith, M. Schapira, 2014, Epigenetics & Chromatin.

Self-renewal as a therapeutic target in human colorectal cancer

A. Krešo, J. Dick, P. V. Galen, 2013, Nature Medicine.

Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors.

Mei Lu, Deena M A Gendoo, Gary D Bader, 2016, Cancer cell.

ATM‐dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post‐translational activation of p53 protein involving poly(ADP‐ribose) polymerase

T. Davison, C. Arrowsmith, S. Benchimol, 1997, The EMBO journal.

Telomere dysfunction cooperates with epigenetic alterations to impair murine embryonic stem cell fate commitment

N. Winegarden, M. Lupien, C. Arrowsmith, 2020, eLife.

Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation.

Bas J. Wouters, M. Minden, O. Abdel-Wahab, 2019, Cancer cell.

Trimethylation of Histone H3 Lysine 36 by Human Methyltransferase PRDM9 Protein

C. Arrowsmith, M. Schapira, M. Vedadi, 2014, The Journal of Biological Chemistry.

Structure and function of dioxygenases in histone demethylation and DNA/RNA demethylation

Chao Xu, J. Min, C. Arrowsmith, 2014, IUCrJ.

Functional diversification of the NleG effector family in enterohemorrhagic Escherichia coli

C. Arrowsmith, S. Houliston, A. Lemak, 2018, Proceedings of the National Academy of Sciences.

A Radioactivity-Based Assay for Screening Human m6A-RNA Methyltransferase, METTL3-METTL14 Complex, and Demethylase ALKBH5

Chao Xu, C. Arrowsmith, M. Vedadi, 2016, Journal of biomolecular screening.

MYC protein interactors in gene transcription and cancer

D. Andrews, B. Raught, C. Arrowsmith, 2021, Nature Reviews Cancer.

Solution structure of ribosomal protein L40E, a unique C4 zinc finger protein encoded by archaeon Sulfolobus solfataricus

J. Lukin, C. Arrowsmith, A. Lemak, 2008, Protein science : a publication of the Protein Society.

SPINE: an integrated tracking database and data mining approach for identifying feasible targets in high-throughput structural proteomics

Mark Gerstein, Deyou Zheng, Yuval Kluger, 2001, Nucleic Acids Res..

Basic Tilted Helix Bundle - a new protein fold in human FKBP25/FKBP3 and HectD1.

J. Almlöf, C. Arrowsmith, A. Lemak, 2014, Biochemical and biophysical research communications.

Structure-activity relationship studies of G9a-like protein (GLP) inhibitors.

C. Arrowsmith, M. Vedadi, Jian Jin, 2017, Bioorganic & medicinal chemistry.

Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase.

C. Arrowsmith, M. Vedadi, Jian Jin, 2017, Journal of medicinal chemistry.

Crystal structure of human Brachyury (T) in complex with DNA

C. Bountra, C. Arrowsmith, O. Gileadi, 2017 .

A chemical toolbox for the study of bromodomains and epigenetic signaling

S. Knapp, O. Fedorov, M. Lupien, 2018, Nature Communications.

Donated chemical probes for open science

Anton Simeonov, Steve Hitchcock, Stefan Laufer, 2018, eLife.

WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma.

R. C. Poulos, J. W. Wong, C. Arrowsmith, 2015, Cancer research.

Optimizing Production of Antigens and Fabs in the Context of Generating Recombinant Antibodies to Human Proteins

J. Greenblatt, A. Koide, S. Koide, 2015, PloS one.

A survey of proteins encoded by non-synonymous single nucleotide polymorphisms reveals a significant fraction with altered stability and activity.

Matthieu Schapira, Abdellah Allali-Hassani, John Moult, 2009, The Biochemical journal.

MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis.

P. Boutros, Benjamin Haibe-Kains, D. Cescon, 2018, Cancer cell.

Structure of the Catalytic Domain of EZH2 Reveals Conformational Plasticity in Cofactor and Substrate Binding Sites and Explains Oncogenic Mutations

C. Arrowsmith, M. Schapira, M. Vedadi, 2013, PloS one.

Histone recognition by human malignant brain tumor domains.

C. Arrowsmith, Shili Duan, N. Zhong, 2012, Journal of molecular biology.

Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation.

Ryan D. Morin, R. Gascoyne, M. Boyle, 2011, Blood.

Epigenetic siRNA and Chemical Screens Identify SETD8 Inhibition as a Therapeutic Strategy for p53 Activation in High-Risk Neuroblastoma.

J. Khan, E. Appella, Ying Hu, 2017, Cancer cell.

NMR solution structure of Thermotoga maritima protein TM1509 reveals a Zn-metalloprotease-like tertiary structure

T. Szyperski, C. Arrowsmith, R. Xiao, 2005, Journal of Structural and Functional Genomics.

Discovery of selective activators of PRC2 mutant EED-I363M

S. Frye, C. Arrowsmith, M. Vedadi, 2019, Scientific Reports.

The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex.

Jun Guo, Kenneth M Comess, Haizhong Zhu, 2017, Nature chemical biology.

trimethylation of selectively altered PRC2 catalytic activity, to increase H3K27 Somatic mutations at EZH2 Y641 act dominantly through a mechanism

R. Gascoyne, M. Boyle, B. Meissner, 2011 .

Chemical genetics screen identifies COPB2 tool compounds that alters ER stress response and induces RTK dysregulation in lung cancer cells.

M. Tyers, G. Poda, V. Wong, 2021, Journal of molecular biology.

Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.

Alexey Bochkarev, Wolfram Tempel, Anne Mulichak, 2007, Molecular and biochemical parasitology.

The MLL1 trimeric catalytic complex is a dynamic conformational ensemble stabilized by multiple weak interactions

R. Aebersold, Yun-Xing Wang, C. Arrowsmith, 2019, Nucleic acids research.

MLL1 minimal catalytic complex is a dynamic conformational ensemble susceptible to pharmacological allosteric disruption

R. Aebersold, Yun-Xing Wang, C. Arrowsmith, 2018, bioRxiv.

Targeting human SET1/MLL family of proteins

C. Arrowsmith, M. Vedadi, M. Eram, 2017, Protein science : a publication of the Protein Society.

HMCES Functions in the Alternative End-Joining Pathway of the DNA DSB Repair during Class Switch Recombination in B Cells.

L. Aravind, C. Arrowsmith, A. Rao, 2020, Molecular cell.

Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma

Lincoln D. Stein, John B Wojcik, P. Sorensen, 2020, Cell.

Aspartate Dehydrogenase, a Novel Enzyme Identified from Structural and Functional Studies of TM1643*

C. Arrowsmith, L. Tong, Rongguang Zhang, 2003, The Journal of Biological Chemistry.

Crystal Structure of Thermotoga maritima 0065, a Member of the IclR Transcriptional Factor Family*

R. Laskowski, A. Joachimiak, C. Arrowsmith, 2002, The Journal of Biological Chemistry.

A small-molecule inhibitor of BCL6 kills DLBCL cells in vitro and in vivo.

Alexander D. MacKerell, Jose M Polo, Alexander D Mackerell, 2010, Cancer cell.

CUL7 is a novel antiapoptotic oncogene.

M. Shago, P. Boutros, I. Jurisica, 2007, Cancer research.

Role of Pirh2 in Mediating the Regulation of p53 and c-Myc

P. Boutros, I. Jurisica, A. Mes-Masson, 2011, PLoS genetics.

Methylation-state-specific recognition of histones by the MBT repeat protein L3MBTL2

Randy J. Read, Matthieu Schapira, Abdellah Allali-Hassani, 2009, Nucleic acids research.

A SPOT on the chromatin landscape? Histone peptide arrays as a tool for epigenetic research.

J. Min, F. Chédin, C. Arrowsmith, 2008, Trends in biochemical sciences.

L3MBTL1 recognition of mono- and dimethylated histones

Abdellah Allali-Hassani, Cheryl H Arrowsmith, Jinrong Min, 2007, Nature Structural &Molecular Biology.

The ZIP5 Ectodomain Co-Localizes with PrP and May Acquire a PrP-Like Fold That Assembles into a Dimer

L. Kay, C. Arrowsmith, A. Yee, 2013, PloS one.

Crystal Structure of the KELCH domain of human KEAP1

C. Bountra, F. von Delft, C. Arrowsmith, 2019 .

Structure-Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase.

Kyle V. Butler, C. Arrowsmith, M. Vedadi, 2016, Journal of medicinal chemistry.

Methyltransferase inhibitors for modulation of the epigenome and beyond.

C. Arrowsmith, M. Schapira, 2016, Current opinion in chemical biology.

Discovery of a Selective, Substrate-Competitive Inhibitor of the Lysine Methyltransferase SETD8

Kyle V. Butler, S. Frye, W. Janzen, 2014, Journal of medicinal chemistry.

Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation.

N. Penrod, M. Lupien, C. Arrowsmith, 2014, The Journal of clinical investigation.

Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines.

Anton Simeonov, Feng Liu, Ajit Jadhav, 2010, Journal of medicinal chemistry.

Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a.

Anton Simeonov, Feng Liu, Ajit Jadhav, 2009, Journal of medicinal chemistry.

Prevalent p53 mutants co-opt chromatin pathways to drive cancer growth

Cheryl H. Arrowsmith, Greg Donahue, Ali Shilatifard, 2015, Nature.

Structure and functionality of a designed p53 dimer.

T. Davison, C. Arrowsmith, C. Kay, 2001, Journal of molecular biology.

Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells

J. Haynes, A. Krešo, M. Lupien, 2019, Nature Communications.

Latent and active p53 are identical in conformation

L. Kay, C. Arrowsmith, F. Mulder, 2001, Nature Structural Biology.

Placental Transforming Growth Factor-β Is a Downstream Mediator of the Growth Arrest and Apoptotic Response of Tumor Cells to DNA Damage and p53 Overexpression*

C. Arrowsmith, A. Ayed, Pei-Xiang Li, 2000, The Journal of Biological Chemistry.

Structural proteomics of an archaeon

Mark Gerstein, Yuval Kluger, Kalle Gehring, 2000, Nature Structural Biology.

Enzyme genomics: Application of general enzymatic screens to discover new enzymes.

Cheryl H Arrowsmith, Jeffrey Reinking, C. Arrowsmith, 2005, FEMS microbiology reviews.

The SMX DNA Repair Tri-nuclease

S. West, C. Arrowsmith, R. Laister, 2017, Molecular cell.

The solution structures of Escherichia coli trp repressor and trp aporepressor at an intermediate resolution.

O Jardetzky, R. Altman, O. Jardetzky, 1991, European journal of biochemistry.

p53 Transcriptional Activation Domain: A Molecular Chameleon?

C. Arrowsmith, E. Bochkareva, L. Kaustov, 2006, Cell cycle.

Synthesis, Optimization, and Evaluation of Novel Small Molecules as Antagonists of WDR5-MLL Interaction.

G. Poda, C. Arrowsmith, M. Schapira, 2013, ACS medicinal chemistry letters.

Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5

G. Poda, C. Arrowsmith, M. Schapira, 2012, The Biochemical journal.

SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/β-Catenin and Hippo/YAP Signaling.

M. Gold, C. Arrowsmith, Toshiro Sato, 2016, Developmental cell.

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia

G. Poda, G. Superti-Furga, K. Bennett, 2015, Nature chemical biology.

Structural insights into aldosterone synthase substrate specificity and targeted inhibition.

C. Arrowsmith, Hee-won Park, A. Gilep, 2013, Molecular endocrinology.

Revealing the protein propionylation activity of the histone acetyltransferase MOF (males absent on the first)

C. Arrowsmith, Yingming Zhao, Xiang-Jiao Yang, 2018, The Journal of Biological Chemistry.

Multivalent histone engagement by the linked tandem Tudor and PHD domains of UHRF1 is required for the epigenetic inheritance of DNA methylation.

B. Strahl, C. Arrowsmith, S. Houliston, 2013, Genes & development.

Association of UHRF1 with H3K9 methylation directs the maintenance of DNA methylation

B. Strahl, C. Arrowsmith, K. Krajewski, 2012, Nature Structural &Molecular Biology.

Biophysical characterization of recombinant proteins: A key to higher structural genomics success

C. Arrowsmith, M. Vedadi, A. Allali-Hassani, 2010, Journal of structural biology.

A Human Ubiquitin Conjugating Enzyme (E2)-HECT E3 Ligase Structure-function Screen*

Tharan Srikumar, Brian Raught, Ryan Doherty, 2012, Molecular & Cellular Proteomics.

The Conserved CPH Domains of Cul7 and PARC Are Protein-Protein Interaction Modules That Bind the Tetramerization Domain of p53*

J. Lukin, C. Arrowsmith, A. Lemak, 2007, Journal of Biological Chemistry.

Deep trefoil knot implicated in RNA binding found in an archaebacterial protein

Youngchang Kim, Cheryl H Arrowsmith, Andrzej Joachimiak, 2002, Proteins.

Myxoma virus immunomodulatory protein M156R is a structural mimic of eukaryotic translation initiation factor eIF2alpha.

C. Arrowsmith, A. Yee, T. Ramelot, 2002, Journal of molecular biology.

The Structural Basis for Methylmalonic Aciduria

A. Joachimiak, C. Arrowsmith, V. Saridakis, 2004, Journal of Biological Chemistry.

Design and synthesis of selective, small molecule inhibitors of coactivator-associated arginine methyltransferase 1 (CARM1).

C. Arrowsmith, M. Vedadi, M. Eram, 2016, MedChemComm.

The Structural Basis for Methylmalonic Aciduria THE CRYSTAL STRUCTURE OF ARCHAEAL ATP:COBALAMIN ADENOSYLTRANSFERASE*

A. Joachimiak, C. Arrowsmith, V. Saridakis, 2004 .

Target 2035: probing the human proteome.

Matthias Zwick, Cheryl H Arrowsmith, Anke Mueller-Fahrnow, 2019, Drug discovery today.

Identification and Structure-Activity Relationship of HDAC6 Zinc-Finger Ubiquitin Binding Domain Inhibitors.

H. Ouyang, C. Arrowsmith, M. Schapira, 2018, Journal of medicinal chemistry.

Small Molecule Antagonists of the Interaction between the Histone Deacetylase 6 Zinc-Finger Domain and Ubiquitin.

H. Ouyang, F. von Delft, C. Arrowsmith, 2017, Journal of medicinal chemistry.

Discovery of Ubiquitin Deamidases in the Pathogenic Arsenal of Legionella pneumophila.

Malene L Urbanus, Cheryl H Arrowsmith, C. Arrowsmith, 2018, Cell reports.

Transient structure and dynamics in the disordered c-Myc transactivation domain affect Bin1 binding

Julie D. Forman-Kay, Cheryl H. Arrowsmith, Alexander Lemak, 2012, Nucleic acids research.

RPRD 1 A and RPRD 1 B Are Human RNA Polymerase II C-Terminal Domain Scaffolds for Ser 5 Dephosphorylation

A. Emili, Xinghua Guo, Joyce Li, 2014 .

Interferon-inducible protein 16: insight into the interaction with tumor suppressor p53.

Yun-Xing Wang, C. Arrowsmith, N. Chirgadze, 2011, Structure.

High-throughput production of prokaryotic membrane proteins

James E. Bray, Cheryl H. Arrowsmith, Aled M. Edwards, 2005, Journal of Structural and Functional Genomics.

Refolding out of guanidine hydrochloride is an effective approach for high‐throughput structural studies of small proteins

C. Arrowsmith, D. Bona, K. Maxwell, 2003, Protein science : a publication of the Protein Society.

Structure and function of the PWI motif: a novel nucleic acid-binding domain that facilitates pre-mRNA processing.

B. Blencowe, B. Graveley, C. Arrowsmith, 2003, Genes & development.

Solution structure of the tetrameric minimum transforming domain of p53

C. Arrowsmith, Weontae Lee, T. Harvey, 1995, Nature Structural Biology.

Letter to the Editor: 1H, 13C, and 15N resonance assignments and secondary structure of the PWI domain from SRm160 using Reduced Dimensionality NMR

T. Szyperski, C. Arrowsmith, A. Pineda-Lucena, 2002, Journal of biomolecular NMR.

LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2

B. Garcia, R. Campbell, C. Arrowsmith, 2015, The Journal of Biological Chemistry.

The structure-activity relationships of L3MBTL3 inhibitors: flexibility of the dimer interface.

S. Frye, W. Janzen, C. Arrowsmith, 2013, MedChemComm.

Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1).

O. Fedorov, C. Arrowsmith, D. Dilworth, 2019, Journal of medicinal chemistry.

Structure- and Function-based Characterization of a New Phosphoglycolate Phosphatase from Thermoplasma acidophilum*

A. Joachimiak, C. Arrowsmith, D. Christendat, 2004, Journal of Biological Chemistry.

New perceptions of transcription factor properties from NMR.

M. Ikura, C. Arrowsmith, S. Bagby, 1998, Biochemistry and cell biology = Biochimie et biologie cellulaire.

p73 and p63 Are Homotetramers Capable of Weak Heterotypic Interactions with Each Other but Not with p53*

T. Davison, C. Arrowsmith, M. Kaghad, 1999, The Journal of Biological Chemistry.

Cruciform structures are a common DNA feature important for regulating biological processes

Cheryl Arrowsmith, Václav Brázda, C. Arrowsmith, 2011, BMC Molecular Biology.

A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic Cancer.

L. Wood, R. Hruban, C. Curtis, 2017, Cancer cell.

Structural analysis and comparison of the C‐terminal transport signal domains of hemolysin A and leukotoxin A

C. Arrowsmith, V. Ling, Ya-Jie Yin, 1995, FEBS letters.

Discovery of a Dual PRMT5-PRMT7 Inhibitor.

Matthieu Schapira, Cheryl H Arrowsmith, Peter J Brown, 2015, ACS medicinal chemistry letters.

An allosteric inhibitor of protein arginine methyltransferase 3.

Jian Jin, Matthieu Schapira, Alena Siarheyeva, 2012, Structure.

Further insight into substrate recognition by USP7: structural and biochemical analysis of the HdmX and Hdm2 interactions with USP7.

C. Arrowsmith, Y. Sheng, V. Saridakis, 2010, Journal of molecular biology.

The Central Region of BRCA1 Binds Preferentially to Supercoiled DNA

C. Arrowsmith, J. Liao, V. Brázda, 2009, Journal of biomolecular structure & dynamics.

Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks.

Cheryl H Arrowsmith, Daniel Durocher, D. Durocher, 2012, Molecular cell.

Structure-Activity Relationship Studies for Enhancer of Zeste Homologue 2 (EZH2) and Enhancer of Zeste Homologue 1 (EZH1) Inhibitors.

Jian Jin, Jamel Meslamani, Cheryl H Arrowsmith, 2016, Journal of medicinal chemistry.

Four p(53)s in a pod

C. Arrowsmith, S. Chitayat, 2010, Nature Structural &Molecular Biology.

DNA Binding Specificity Studies of Four ETS Proteins Support an Indirect Read-out Mechanism of Protein-DNA Recognition* 210

C. Arrowsmith, C H Arrowsmith, B. Szymczyna, 2000, The Journal of Biological Chemistry.

Structural and Chemical Profiling of the Human Cytosolic Sulfotransferases

Rafael Najmanovich, Alexey Bochkarev, Abdellah Allali-Hassani, 2007, PLoS biology.

High throughput screening of purified proteins for enzymatic activity.

Cheryl H Arrowsmith, C. Arrowsmith, A. Yakunin, 2008, Methods in molecular biology.

DOT1L inhibition attenuates graft-versus-host disease by allogeneic T cells in adoptive immunotherapy models

C. Arrowsmith, Chung-Hsi Wang, Tingxi Guo, 2018, Nature Communications.

Kinetic characterization of human histone H3 lysine 36 methyltransferases, ASH1L and SETD2.

C. Arrowsmith, M. Schapira, M. Vedadi, 2015, Biochimica et biophysica acta.

AKT drives SOX2 overexpression and cancer cell stemness in esophageal cancer by protecting SOX2 from UBR5-mediated degradation

C. Arrowsmith, J. Wong, Zhen Wang, 2019, Oncogene.

BET bromodomain inhibition enhances T cell persistence and function in adoptive immunotherapy models.

C. Arrowsmith, Tingxi Guo, M. Butler, 2016, The Journal of clinical investigation.

Elongin from Saccharomyces cerevisiae *

R. Conaway, J. Conaway, C. Arrowsmith, 2000, The Journal of Biological Chemistry.

Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex

J. Greenblatt, C. Arrowsmith, Shili Duan, 2018, Nucleic acids research.

Recognition of Multivalent Histone States Associated with Heterochromatin by UHRF1 Protein*

Shili Duan, Abdellah Allali-Hassani, Cheryl H. Arrowsmith, 2011, The Journal of Biological Chemistry.

A semi-automated organoid screening method demonstrates epigenetic control of intestinal epithelial maturation

C. Arrowsmith, M. T. Pedersen, J. V. von Kries, 2020, bioRxiv.

Structural and Biochemical Characterization of Phage λ FI Protein (gpFI) Reveals a Novel Mechanism of DNA Packaging Chaperone Activity*

C. Arrowsmith, A. Davidson, Bin Wu, 2012, The Journal of Biological Chemistry.

Cbx2 targets PRC1 to constitutive heterochromatin in mouse zygotes in a parent-of-origin-dependent manner.

C. Arrowsmith, L. Kaustov, Shili Duan, 2015, Molecular cell.

Identifying and Validating MYC:Protein Interactors in Pursuit of Novel Anti-MYC Therapies.

B. Raught, C. Arrowsmith, L. Penn, 2021, Methods in molecular biology.

The Solution Structure of the Bacteriophage λ Head–Tail Joining Protein, gpFII

C. Arrowsmith, A. Davidson, A. Yee, 2002 .

The solution structure of bacteriophage lambda protein W, a small morphogenetic protein possessing a novel fold.

C. Arrowsmith, A. Davidson, A. Yee, 2001, Journal of molecular biology.

Characterization of inv(3) cell line OCI-AML-20 with stroma-dependent CD34 expression.

J. Dick, M. Minden, M. Lupien, 2019, Experimental hematology.

Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells

J. Haynes, A. Krešo, M. Lupien, 2019, Nature Communications.

LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium

C. Arrowsmith, Toshiro Sato, F. Drabløs, 2020, Science Advances.

Solution NMR Structure and Histone Binding of the PHD Domain of Human MLL5

S. Aparicio, C. Arrowsmith, S. Houliston, 2013, PloS one.

Structural basis for molecular recognition and presentation of histone H3 By WDR5

Alexey Bochkarev, Abdellah Allali-Hassani, Peter Loppnau, 2006, The EMBO journal.

A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization

Matthew J. Meiners, J. Greenblatt, J. Min, 2021, Nature Chemical Biology.

Pharmacological targeting of a PWWP domain demonstrates cooperative control of NSD2 localization

Matthew J. Meiners, J. Greenblatt, J. Min, 2021, bioRxiv.

RPRD1A and RPRD1B Are Human RNA Polymerase II C-Terminal Domain Scaffolds for Ser5 Dephosphorylation

A. Emili, Xinghua Guo, Joyce Li, 2014, Nature Structural &Molecular Biology.

Probing the epigenome.

S. Knapp, C. Arrowsmith, M. Schapira, 2015, Nature chemical biology.

Somatic mutations at EZH 2 Y 641 act dominantly through a mechanism of selectively altered PRC 2 catalytic activity , to increase H 3 K 27 trimethylation

Ryan D. Morin, R. Gascoyne, M. Boyle, 2011 .

Structural Characterization of Interaction between Human Ubiquitin-specific Protease 7 and Immediate-Early Protein ICP0 of Herpes Simplex Virus-1*

C. Arrowsmith, D. Korzhnev, S. Weller, 2015, The Journal of Biological Chemistry.

A semi-automated intestinal organoid screening method demonstrates epigenetic control of epithelial maturation

C. Arrowsmith, M. T. Pedersen, P. Jay, 2020 .

Biochemical and structural characterization of a novel family of cystathionine beta-synthase domain proteins fused to a Zn ribbon-like domain.

A. Murzin, J. Lukin, A. Joachimiak, 2008, Journal of molecular biology.

Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine.

D. Durocher, C. Arrowsmith, F. Sicheri, 2008, Molecular cell.

An unusual mode of galactose recognition by a family 32 carbohydrate-binding module.

C. Arrowsmith, S. Houliston, A. Boraston, 2014, Journal of molecular biology.

Molecular basis of Pirh2-mediated p53 ubiquitylation

J. Lukin, C. Arrowsmith, A. Lemak, 2008, Nature Structural &Molecular Biology.

The HD Domain of the Escherichia coli tRNA Nucleotidyltransferase Has 2′,3′-Cyclic Phosphodiesterase, 2′-Nucleotidase, and Phosphatase Activities*

C. Arrowsmith, A. Savchenko, A. Yakunin, 2004, Journal of Biological Chemistry.

Altered RNA splicing initiates the viral mimicry response from inverted SINEs following type I PRMT inhibition in Triple-Negative Breast Cancer

Benjamin Haibe-Kains, D. Cescon, M. Lupien, 2021 .

The human pseudouridine synthase PUS7 recognizes RNA with an extended multi-domain binding surface

C. Arrowsmith, A. Dong, Julia Guéguéniat, 2021, Nucleic acids research.

The RNF168 paralog RNF169 defines a new class of ubiquitylated histone reader involved in the response to DNA damage

G. Portella, D. Durocher, L. Kay, 2017, eLife.

The RNF 168 paralog RNF 169 defines a new class of ubiquitylated histone reader involved in the response to DNA damage

G. Portella, D. Durocher, L. Kay, 2017 .

Characterization of binding‐induced changes in dynamics suggests a model for sequence‐nonspecific binding of ssDNA by replication protein A

C. Arrowsmith, W. Chazin, M. Botuyan, 2002, Protein science : a publication of the Protein Society.

Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2

Clara D. Christ, C. Arrowsmith, H. Weinmann, 2016, Journal of medicinal chemistry.

The study of epigenetic mechanisms based on the analysis of histone modification patterns by flow cytoametry

M. Minden, D. Hedley, C. Arrowsmith, 2014, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

Expanding the Huntington’s disease research toolbox; validated subdomain protein constructs for biochemical and structural investigation of huntingtin

E. Wanker, C. Arrowsmith, S. Lea, 2022, bioRxiv.

Huntingtin structure is orchestrated by HAP40 and shows a polyglutamine expansion-specific interaction with exon 1

A. Heck, C. Arrowsmith, A. Lemak, 2021, Communications Biology.

HAP40 orchestrates huntingtin structure for differential interaction with polyglutamine expanded exon 1

A. Heck, C. Arrowsmith, A. Lemak, 2021, bioRxiv.

Discovery of Nanomolar DCAF1 Small Molecule Ligands.

Anthony D. Keefe, Christopher J. Mulhern, A. Keefe, 2023, Journal of medicinal chemistry.

Design and characterization of mutant and wildtype huntingtin proteins produced from a toolkit of scalable eukaryotic expression systems

C. Arrowsmith, A. Lemak, A. Holehouse, 2019, The Journal of Biological Chemistry.

Solution NMR structure of the HLTF HIRAN domain: a conserved module in SWI2/SNF2 DNA damage tolerance proteins

C. Arrowsmith, D. Korzhnev, D. Neculai, 2016, Journal of Biomolecular NMR.

Thermodynamic analysis of the structural stability of the tetrameric oligomerization domain of p53 tumor suppressor.

C. Arrowsmith, E. Freire, P. Morin, 1995, Biochemistry.

Solution NMR Structure of Hypothetical Protein CV_2116 Encoded by a Viral Prophage Element in Chromobacterium violaceum

C. Arrowsmith, A. Yee, T. Ramelot, 2012, International journal of molecular sciences.

Anti-Ro52 Autoantibodies from Patients with Sjögren's Syndrome Inhibit the Ro52 E3 Ligase Activity by Blocking the E3/E2 Interface*

C. Arrowsmith, Y. Sheng, J. Hennig, 2011, The Journal of Biological Chemistry.

Sequence-Specific Recognition of a PxLPxI/L Motif by an Ankyrin Repeat Tumbler Lock

T. Pawson, Chao Xu, C. Bian, 2012, Science Signaling.

Data mining crystallization databases: Knowledge‐based approaches to optimize protein crystal screens

Mark Gerstein, Steven Beasley, Masoud Vedadi, 2003, Proteins.

The MYC oncoprotein directly interacts with its chromatin cofactor PNUTS to recruit PP1 phosphatase

D. Andrews, C. Arrowsmith, S. Houliston, 2022, Nucleic acids research.

The PNUTS-PAD domain recruits MYC to the PNUTS:PP1 phosphatase complex via the oncogenic MYC-MB0 region

D. Andrews, C. Arrowsmith, S. Houliston, 2021, bioRxiv.

Domain–domain motions in proteins from time-modulated pseudocontact shifts

J. Prestegard, C. Arrowsmith, A. Lemak, 2007, Journal of biomolecular NMR.

A Suite of Biochemical Assays for Screening RNA Methyltransferase BCDIN3D

C. Arrowsmith, M. Vedadi, Y. Zheng, 2017, SLAS discovery : advancing life sciences R & D.

Solution-state NMR structure of the putative morphogene protein BolA (PFE0790c) from Plasmodium falciparum.

P. Myler, C. Arrowsmith, G. W. Buchko, 2015, Acta crystallographica. Section F, Structural biology communications.

Eme1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cells

S. West, M. Hande, C. Chahwan, 2003, The EMBO journal.

Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1.

Yunxiang Mu, Bradley M Dickson, Brian D Strahl, 2015, ACS chemical biology.

Conformational dynamics of the TTD–PHD histone reader module of the UHRF1 epigenetic regulator reveals multiple histone-binding states, allosteric regulation, and druggability

Yun-Xing Wang, C. Arrowsmith, A. Lemak, 2017, The Journal of Biological Chemistry.

Early‐life antibiotic treatment enhances the pathogenicity of CD4+ T cells during intestinal inflammation

M. Lupien, C. Arrowsmith, M. Taves, 2017, Journal of leukocyte biology.

Protein production: feeding the crystallographers and NMR spectroscopists

Cheryl H. Arrowsmith, James D. Friesen, Aled M. Edwards, 2000, Nature Structural Biology.

The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates

Sebastian A. Leidel, S. Leidel, J. Olsen, 2018, Nature Communications.

Crystal structure of JMJD5 domain of human Lysine-specific demethylase 8 (KDM8) in complex with N-oxalylglycine (NOG)

C. Bountra, C. Allerston, C. Arrowsmith, 2012 .

cGAS recruitment to micronuclei is dictated by pre-existing nuclear chromatin status

C. Arrowsmith, S. Harding, Kate MacDonald, 2022, bioRxiv.

Human METTL3-METTL14 complex

Cheryl H. Arrowsmith, Wolfram Tempel, C. Bountra, 2016 .

A novel member of the YchN‐like fold: Solution structure of the hypothetical protein Tm0979 from Thermotoga maritima

C. Arrowsmith, P. Stathopulos, Kenrick A. Vassall, 2005, Protein Science.

X‐ray crystal structure of CutA from Thermotoga maritima at 1.4 Å resolution

R. Laskowski, J. Watson, A. Joachimiak, 2003, Proteins.

Discovery of a Potent and Selective Targeted NSD2 Degrader for the Reduction of H3K36me2.

Laura E. Herring, J. Licht, C. Arrowsmith, 2023, Journal of the American Chemical Society.

Biological and Structural Basis for Aha1 Regulation of Hsp90 ATPase Activity in Maintaining Proteostasis in the Human Disease Cystic Fibrosis

J. Yates, M. Dong, C. Arrowsmith, 2010, Molecular biology of the cell.

Structural characterization of USP7 – ICP0 interaction

C. Arrowsmith, D. Korzhnev, S. Weller, 2015 .

Letter to the Editor: 1H, 13C and 15N Assignments of Single-Stranded DNA Binding Domains from the 70 kDa Subunit of Human Replication Protein A

C. Arrowsmith, W. Chazin, M. Botuyan, 2004, Journal of Biomolecular NMR.

Crystal structure of human Dipeptidyl Peptidase III

C. Bountra, C. Arrowsmith, A. Bochkarev, 2009 .

Solution structure of the human Pirh2 RING-H2 domain. Northeast Structural Genomics Consortium Target HT2B

Cheryl H. Arrowsmith, Yi Sheng, Alexander Lemak, 2007 .

Antecedent chromatin organization determines cGAS recruitment to ruptured micronuclei

C. Arrowsmith, S. Harding, Sarika Khasnis, 2023, Nature Communications.

Structural basis of HMCES interactions with DNA reveals multivalent substrate recognition

L. Aravind, C. Arrowsmith, A. Rao, 2019, bioRxiv.

Correction: Structural and Chemical Profiling of the Human Cytosolic Sulfotransferases

Janet M. Thornton, Abdellah Allali-Hassani, Alexander N. Plotnikov, 2007, PLoS Biology.

Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2

J. Min, C. Arrowsmith, M. Schapira, 2020, bioRxiv.

De novo design of immunoglobulin-like domains

D. Baker, C. Arrowsmith, T. M. Chidyausiku, 2021, bioRxiv.

Validating Small Molecule Chemical Probes for Biological Discovery.

C. Arrowsmith, M. Szewczyk, D. Barsyte-Lovejoy, 2022, Annual review of biochemistry.

Target 2035 – update on the quest for a probe for every protein

G. A. Bezerra, T. Willson, G. Superti-Furga, 2021, RSC medicinal chemistry.

Structural Proteomics: Toward High‐Throughput Structural Biology as a Tool in Functional Genomics

Cheryl H. Arrowsmith, Aled M. Edwards, C. Arrowsmith, 2003 .

Letter to the Editor: Complete 1H, 13C and 15N NMR assignments of MTH0776 from Methanobacterium thermoautotrophicum

Paul Stothard, David S Wishart, Zhan Chang, 2004, Journal of biomolecular NMR.

Binding of elongin A or a von Hippel-Lindau peptide stabilizes the structure of yeast elongin C.

R. Conaway, J. Conaway, C. Arrowsmith, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Crystal Structure of Fushi Tarazu Factor 1 Ligand Binding Domain/Fushi Tarazu Peptide Complex Identifies New Class of Nuclear Receptors*

H. Krause, C. Arrowsmith, Weontae Lee, 2011, The Journal of Biological Chemistry.

Discovery of Peptidomimetic Ligands of EED as Allosteric Inhibitors of PRC2.

S. Frye, C. Arrowsmith, M. Vedadi, 2017, ACS combinatorial science.

Control of the hippo pathway by Set7-dependent methylation of Yap.

Amber L. Couzens, A. Gingras, M. Gold, 2013, Developmental cell.

Solution structure of YKR049C, a putative redox protein from Saccharomyces cerevisiae.

Bin Wu, Weontae Lee, Cheryl H Arrowsmith, 2005, Journal of biochemistry and molecular biology.

Crystal structure of human spermine synthase in complex with spermidine and 5-methylthioadenosine

J. Min, C. Arrowsmith, J. Weigelt, 2008 .

NMR and X-ray crystallography, complementary tools in structural proteomics of small proteins.

Cheryl H Arrowsmith, J. Lukin, C. Arrowsmith, 2005, Journal of the American Chemical Society.

Nahuoic acid A produced by a Streptomyces sp. isolated from a marine sediment is a selective SAM-competitive inhibitor of the histone methyltransferase SETD8.

David E. Williams, R. Andersen, C. Arrowsmith, 2013, Organic letters.

Design, Synthesis, and Evaluation of WD-Repeat-Containing Protein 5 (WDR5) Degraders.

B. Kuster, S. Knapp, C. Sotriffer, 2021, Journal of medicinal chemistry.

Design, Synthesis and Evaluation of WD-repeat containing protein 5 (WDR5) degraders

B. Kuster, S. Knapp, C. Sotriffer, 2021, bioRxiv.

PRMT1 is a critical dependency in clear cell renal cell carcinoma through its role in post-transcriptional regulation of DNA damage response genes

B. Raught, C. Arrowsmith, P. Prinos, 2023, bioRxiv.

Structural analysis of HopPmaL reveals the presence of a second adaptor domain common to the HopAB family of Pseudomonas syringae type III effectors.

C. Arrowsmith, S. Houliston, A. Yee, 2012, Biochemistry.

A chemical biology toolbox to study protein methyltransferases and epigenetic signaling

Jennifer A. Ward, P. Richardson, C. Arrowsmith, 2018, bioRxiv.

Crystal structure of the nucleotide-binding domain of Ras-related GTP-binding protein C

C. Bountra, C. Arrowsmith, J. Weigelt, 2010 .

Crystal Structure of human NAD kinase

C. Bountra, C. Arrowsmith, J. Weigelt, 2010 .

Detection of antibodies against the huntingtin protein in human plasma

R. Barker, C. Arrowsmith, F. Cicchetti, 2023, Cellular and Molecular Life Sciences.

MAPK14 with bound inhibitor SR-318

S. Knapp, C. Bountra, C. Arrowsmith, 2019 .

Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors

Jayme L. Dahlin, J. Baell, M. Walters, 2017, Nature Communications.

Target 2035 – an update on private sector contributions

T. Willson, S. Knapp, U. Lessel, 2023, RSC medicinal chemistry.

Design of a fluorescent ligand targeting the S-adenosylmethionine binding site of the histone methyltransferase MLL1.

C. Arrowsmith, S. Houliston, M. Vedadi, 2016, Organic & biomolecular chemistry.

Abstract 1646: Discovery and characterization of BAY-6035, a novel benzodiazepine-based SMYD3 inhibitor

Clara D. Christ, C. Arrowsmith, A. Haegebarth, 2018, Cancer Chemistry.

SETDB1 Triple Tudor Domain Ligand, (R,R)-59, Promotes Methylation of Akt1 in Cells

S. Frye, C. Arrowsmith, K. Pearce, 2023, bioRxiv.

Identification and characterization of the first fragment hits for SETDB1 Tudor domain.

J. Min, C. Arrowsmith, S. Houliston, 2019, Bioorganic & medicinal chemistry.

Identification and Characterization of the First Fragment Hits for SETDB1 Tudor Domain

J. Min, C. Arrowsmith, S. Houliston, 2019, bioRxiv.

The hypothetical protein Atu4866 from Agrobacterium tumefaciens adopts a streptavidin‐like fold

S. Li, C. Arrowsmith, A. Yee, 2007, Protein science : a publication of the Protein Society.

Hydrogen Isotope Fractionation Factors for Benzylamine and Benzylammonium Ion. Comparison of Fractionation Factors for Neutral and Positively-Charged Nitrogen-Hydrogen Bonds

C. Arrowsmith, A. Kresge, H.-X. Guo, 1994 .

NMR of large (s> 25 kDa) proteins and protein complexes

C. Arrowsmith, Wu Yu-Sung, 1998 .

Structure Activity Relationship of USP5 Allosteric Inhibitors

C. Arrowsmith, M. Schapira, R. Al-awar, 2021, bioRxiv.

Crystal Structure of dTDP-4-keto-6-deoxy-d-hexulose 3,5-Epimerase fromMethanobacterium thermoautotrophicum Complexed with dTDP*

E. Pai, C. Arrowsmith, V. Saridakis, 2000, The Journal of Biological Chemistry.

Crystal Structure of the Complex between the 25 kDa Subunit and the 59 kDa Subunit (RRM domain) of Human Cleavage Factor Im

P. Nordlund, C. Bountra, C. Arrowsmith, 2010 .

Poly ADP-Ribose Signaling is Dysregulated in Huntington’s Disease Patients

C. Arrowsmith, T. Dawson, V. Dawson, 2022 .

Discovery and Characterization of BAY-805, a Potent and Selective Inhibitor of Ubiquitin-Specific Protease USP21

P. Lienau, C. Arrowsmith, M. Vedadi, 2023, Journal of medicinal chemistry.

Solution structure of TA1092, a ribosomal protein S24e from Thermoplasma acidophilum

C. Arrowsmith, A. Yee, Weontae Lee, 2006, Proteins.

Rational Design and Synthesis of Selective PRMT4 Inhibitors: A New Chemotype for Development of Cancer Therapeutics **

C. Arrowsmith, M. Vedadi, M. Szewczyk, 2021, ChemMedChem.

Zn-binding AZUL domain of human ubiquitin protein ligase Ube3A

C. Arrowsmith, A. Lemak, A. Yee, 2011, Journal of biomolecular NMR.

Structural Genomics by NMR Spectroscopy

C. Arrowsmith, 2007 .

CRYSTAL STRUCTURE OF THE HUMAN PIM1 IN COMPLEX WITH A RUTHENIUM ORGANOMETALLIC LIGAND RU1

S. Knapp, C. Arrowsmith, J. Weigelt, 2005 .

human SETD8 in complex with MS2177

Anqi Ma, Jian Jin, Nicolas Babault, 2016 .

Small-molecule ligands of methyl-lysine binding proteins.

Jian Jin, Cen Gao, Robert Lam, 2011, Journal of medicinal chemistry.

Identification and Structure-Activity Relationship of HDAC6 Zinc-finger Ubiquitin Binding Domain Inhibitors

H. Ouyang, C. Arrowsmith, M. Schapira, 2018, bioRxiv.

Structural Basis of E2–25K/UBB+1 Interaction Leading to Proteasome Inhibition and Neurotoxicity*

S. Eom, C. Arrowsmith, Weontae Lee, 2010, The Journal of Biological Chemistry.

Crystal structure of human Glutamate oxaloacetate transaminase 1 (GOT1)

J. Bray, K. Kavanagh, C. Bountra, 2009 .

Preclinical target validation using patient-derived cells

Arthur S Slutsky, J. Isaac, B. Pollock, 2015, Nature Reviews Drug Discovery.

Crystal Structural of CBX5 Chromo Shadow Domain

H. Ouyang, J. Min, C. Bountra, 2009 .

Solution structure of the yeast ubiquitin-like modifier protein Hub1

C. Arrowsmith, A. Yee, A. Semesi, 2002, Journal of Structural and Functional Genomics.

Discovery and Characterization of a Chemical Probe Targeting the Zinc-Finger Ubiquitin-Binding Domain of HDAC6

C. Arrowsmith, M. Schapira, M. Szewczyk, 2023, bioRxiv.

Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response

Amber L. Couzens, M. Tyers, A. Gingras, 2020, Nature Communications.

1HC and 1HN total NOE correlations in a single 3D NMR experiment. 15N and 13C time-sharing in t1 and t2 dimensions for simultaneous data acquisition

C. Arrowsmith, Xiaolian Gao, A. Yee, 2003, Journal of biomolecular NMR.

A pulsed field gradient isotope‐filtered 3D 13C HMQC‐NOESY experiment for extracting intermolecular NOE contacts in molecular complexes

L. Kay, C. Arrowsmith, L E Kay, 1994, FEBS letters.

Identification of a novel archaebacterial thioredoxin: determination of function through structure.

D. Wishart, C. Arrowsmith, A. Yee, 2002, Biochemistry.

EHMT2/G9a-Inhibition Reprograms Cancer-Associated Fibroblasts (CAFs) to a More Differentiated, Less Proliferative and Invasive State

C. Simmons, A. McGuigan, C. Arrowsmith, 2023, bioRxiv.

A chemical toolbox for the study of bromodomains and epigenetic signaling

S. Knapp, O. Fedorov, M. Lupien, 2019, Nature Communications.

Crystal structure of the BAR domain of human Amphiphysin, isoform 1

C. Bountra, C. Allerston, C. Arrowsmith, 2011 .

Prediction and Validation of a Protein’s Free Energy Surface Using Hydrogen Exchange and (Importantly) Its Denaturant Dependence

Nabil F. Faruk, K. Freed, C. Arrowsmith, 2021, Journal of chemical theory and computation.

The solution structures of the trp repressor-operator DNA complex.

O. Jardetzky, C. Arrowsmith, D. Zhao, 1994, Journal of molecular biology.

Cooperative interaction between the DNA-binding domains of PU.1 and IRF4.

T. Mak, C. Arrowsmith, D. Siderovski, 1998, Journal of molecular biology.

Crystal Structure Of Human 17-Beta-Hydroxysteroid Dehydrogenase Type 4 In Complex With NAD

J. Bray, K. Kavanagh, C. Arrowsmith, 2005 .

ABACUS, a direct method for protein NMR structure computation via assembly of fragments

A. Grishaev, C. Arrowsmith, M. Llinás, 2005, Proteins.

DOT1L inhibition attenuates graft-versus-host disease by allogeneic T cells in adoptive immunotherapy models

C. Arrowsmith, Chung-Hsi Wang, Tingxi Guo, 2018, Nature Communications.

Crystal structure of EHMT1

C. Bountra, C. Arrowsmith, Y. Tong, 2018 .

Toward the solution structure of large (>30 kDa) proteins and macromolecular complexes

L. Kay, C. Arrowsmith, Weontae Lee, 1995 .

Crystal Structure of Human FtsJ homolog 2 (E.coli) protein in complex with S-adenosylmethionine

C. Arrowsmith, J. Weigelt, A. Bochkarev, 2006 .

PR Domain-containing Protein 7 (PRDM7) Is a Histone 3 Lysine 4 Trimethyltransferase*

C. Arrowsmith, M. Schapira, M. Vedadi, 2016, The Journal of Biological Chemistry.

Crystal structure of toxoplasma specific mitochondrial acyl carrier protein, 59.m03510

C. Bountra, C. Arrowsmith, J. Weigelt, 2008 .

A chemical probe to modulate human GID4 Pro/N-degron interactions

S. Knapp, J. Min, C. Arrowsmith, 2023, bioRxiv.

CACHE (Critical Assessment of Computational Hit-finding Experiments): A public–private partnership benchmarking initiative to enable the development of computational methods for hit-finding

Tudor I. Oprea, Rommie E. Amaro, Yoshua Bengio, 2021, Nature Reviews Chemistry.

Solution structure of acyl carrier protein from Nitrosomonas europaea

J. Lukin, C. Arrowsmith, A. Yee, 2006, Proteins.

Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase

C. Arrowsmith, M. Vedadi, Jian Jin, 2017 .

Dissecting the stability determinants of a challenging de novo protein fold using massively parallel design and experimentation

C. Arrowsmith, G. Rocklin, S. Houliston, 2021, bioRxiv.

Solution structure of a novel calcium binding protein, MTH1880, from Methanobacterium thermoautotrophicum

C. Arrowsmith, A. Yee, Chang-Hun Lee, 2004, Protein science : a publication of the Protein Society.

NMR structure of the Escherichia coli protein YacG: A novel sequence motif in the zinc‐finger family of proteins

C. Arrowsmith, A. Yee, A. Semesi, 2002, Proteins.

Structure, activity and inhibition of human TMPRSS2, a protease implicated in SARS-CoV-2 activation

S. Subramaniam, F. Bénard, C. Arrowsmith, 2021, bioRxiv.

The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates

Sebastian A. Leidel, J. Olsen, C. Arrowsmith, 2018, Nature Communications.

A meanfield approach to the thermodynamics of a protein-solvent system with application to the oligomerization of the tumor suppressor p53

T. Davison, J. Noolandi, C. Arrowsmith, 2000 .

Discovery of a Novel DCAF1 Ligand Using a Drug-Target Interaction Prediction Model: Generalizing Machine Learning to New Drug Targets

C. Arrowsmith, M. Schapira, S. Green, 2023, J. Chem. Inf. Model..

Human Pancreatic lipase-related protein 1

C. Arrowsmith, J. Weigelt, A. Bochkarev, 2007 .

Rapid corepressor exchange from the trp-repressor/operator complex: An NMR study of [ul-13C/15N]-l-tryptophan

C. Arrowsmith, Weontae Lee, M. Kainosho, 1995, Journal of biomolecular NMR.

Ubiquitin-specific Protease 7 Is a Regulator of Ubiquitin-conjugating Enzyme UbE2E1*

C. Arrowsmith, K. Wheaton, Y. Sheng, 2013, The Journal of Biological Chemistry.

Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor.

C. Arrowsmith, M. Schapira, M. Vedadi, 2016, Journal of medicinal chemistry.

Sequence-specific 1H NMR assignments and secondary structure in solution of Escherichia coli trp repressor.

O. Jardetzky, C. Arrowsmith, R. Pachter, 1990, Biochemistry.

Crystal structure of TBL1XR1 WD40 repeats

Chao Xu, J. Min, C. Bountra, 2014 .

Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy 1

David J. Jörg, M. Hirst, T. Pugh, 2017 .

Study of a noncovalent trp repressor: DNA operator complex by electrospray ionization time‐of‐flight mass spectrometry

C. Arrowsmith, I. Chernushevich, W. Ens, 1998, Protein science : a publication of the Protein Society.

The effect of selective deuteration on magnetization transfer in larger proteins

O. Jardetzky, C. Arrowsmith, R. Pachter, 1992, Journal of biomolecular NMR.

The use of selective deuteration for the sequence specific 1H NMR assignment of larger proteins

O. Jardetzky, C. Arrowsmith, L. Szilágyi, 1990 .

NMR studies of the Escherichia coli trp aporepressor. Sequence-specific assignment of the aromatic proton resonances.

O. Jardetzky, C. Arrowsmith, G. Roberts, 1989, European journal of biochemistry.

NMR assignments for the amino-terminal residues of trp repressor and their role in DNA binding.

O. Jardetzky, C. Arrowsmith, J. Carey, 1989, Biochemistry.

Determination of Large Protein Structures from NMR Data: Definition of the Solution Structure of the TRP Repressor

R. Altman, O. Jardetzky, C. Arrowsmith, 1991 .

The chromatin and single-cell transcriptional landscapes of CD4 T cells in inflammatory bowel disease link risk loci with a proinflammatory Th17 cell population

M. Silverberg, M. Lupien, C. Arrowsmith, 2023, Frontiers in immunology.

Crystal Structure Analysis of Kelch protein from Plasmodium falciparum

C. Bountra, C. Arrowsmith, S. Gräslund, 2015 .

The solution structure of the bacteriophage lambda head-tail joining protein, gpFII.

C. Arrowsmith, A. Davidson, A. Yee, 2002, Journal of molecular biology.

SETDB1 Triple Tudor Domain Ligand, (R,R)-59, Promotes Methylation of Akt1 in Cells.

S. Frye, C. Arrowsmith, K. Pearce, 2023, ACS Chemical Biology.

A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function.

O. Fedorov, C. Bountra, C. Arrowsmith, 2019, Journal of Medicinal Chemistry.

MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin.

J. Dick, M. Bernstein, S. Pfister, 2015, Cancer Cell.

Human HDAC7 Harbors a Class IIa Histone Deacetylase-specific Zinc Binding Motif and Cryptic Deacetylase Activity*

C. Arrowsmith, M. Schapira, T. Lewis, 2008, Journal of Biological Chemistry.

A Chemical Toolbox for the Study of Bromodomains and Epigenetic Signaling

O. Fedorov, S. Müller, C. Arrowsmith, 2018, bioRxiv.

MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis.

P. Boutros, Benjamin Haibe-Kains, D. Cescon, 2018, Cancer cell.

Biological and Structural Basis for Aha1 Regulation of Hsp90 ATPase Activity in Maintaining Proteostasis in the Human Disease Cystic Fibrosis

J. Yates, C. Arrowsmith, W. Balch, 2010, Molecular biology of the cell.

Solution Structure of MTH0776 from Methanobacterium Thermoautotrophicum

Paul Stothard, David S Wishart, Ekaterina Kuznetsova, 2005, Journal of biomolecular NMR.

Anti-Ro 52 autoantibodies from patients with lupus and Sjögren ' s syndrome inhibit the E 3 ubiquitin ligase activity of Ro 52 by blocking the E 2E 3 interface

C. Arrowsmith, Y. Sheng, J. Hennig, 2014 .

RAS and PP2A activities converge on epigenetic gene regulation

M. Nykter, C. Arrowsmith, M. Schapira, 2023, Life Science Alliance.

MTH187 from Methanobacterium thermoautotrophicum has three HEAT-like Repeats

C. Arrowsmith, A. Yee, S. Gagné, 2006, Journal of biomolecular NMR.

Novel projected 4D triple resonance experiments for polypeptide backbone chemical shift assignment

T. Szyperski, C. Arrowsmith, Youlin Xia, 2002, Journal of biomolecular NMR.

A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic Cancer.

L. Wood, R. Hruban, C. Curtis, 2017, Cancer cell.

Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine.

D. Durocher, C. Arrowsmith, F. Sicheri, 2008, Molecular cell.

Crystal structure of human acyl-CoA dehydrogenase 11

C. Bountra, C. Arrowsmith, J. Weigelt, 2009 .

Sequence specific resonance assignment via Multicanonical Monte Carlo search using an ABACUS approach

C. Arrowsmith, A. Lemak, M. Llinás, 2008, Journal of biomolecular NMR.

The promise and peril of chemical probes (vol 11, pg 536, 2015)

John P. Overington, Jayme L. Dahlin, Christopher M. Austin, 2015 .

The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex.

Mikkel A. Algire, Justin D Dietrich, A. Petros, 2017, Nature chemical biology.

Bromo-deaza-SAH: a potent and selective DOT1L inhibitor.

Matthieu Schapira, Wenyu Yu, Wolfram Tempel, 2013, Bioorganic & medicinal chemistry.

A Semi-automated Organoid Screening Method Demonstrates Epigenetic Control of Intestinal Epithelial Differentiation

C. Arrowsmith, J. V. von Kries, P. Jay, 2021, Frontiers in Cell and Developmental Biology.

A semi-automated organoid screening method demonstrates epigenetic control of intestinal epithelial maturation

C. Arrowsmith, M. T. Pedersen, J. V. von Kries, 2020, bioRxiv.

Recognition of Multivalent Histone States Associated with Heterochromatin by UHRF1 Protein*

Yun-Xing Wang, F. Chédin, C. Arrowsmith, 2011, The Journal of Biological Chemistry.

The solution structure of ribosomal protein S17E from Methanobacterium thermoautotrophicum: A structural homolog of the FF domain

G. Montelione, C. Arrowsmith, A. Yee, 2008, Protein science : a publication of the Protein Society.

Human K-Ras in complex with a GTP analogue

Cheryl H. Arrowsmith, Hee-Won Park, J. Weigelt, 2007 .

Blind testing of routine, fully automated determination of protein structures from NMR data.

Oliver F. Lange, Gaohua Liu, G. Montelione, 2012, Structure.

A novel strategy for NMR resonance assignment and protein structure determination

C. Arrowsmith, A. Lemak, C. Farés, 2011, Journal of biomolecular NMR.

Crystal structure of VEGFR1 in complex with N-(4-Chlorophenyl)-2-((pyridin-4-ylmethyl)amino)benzamide

P. Nordlund, C. Bountra, C. Arrowsmith, 2009 .

NMR structure of the hypothetical protein encoded by the YjbJ gene from Escherichia coli

C. Arrowsmith, A. Yee, A. Pineda-Lucena, 2002, Proteins.

Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase.

C. Arrowsmith, M. Vedadi, Jian Jin, 2017, Journal of medicinal chemistry.

ABACUS, a direct method for protein NMR structure computation via assembly of fragments

C. Arrowsmith, A. Pineda-Lucena, Miguel Llinás, 2005, Proteins.

Basic Tilted Helix Bundle - a new protein fold in human FKBP25/FKBP3 and HectD1.

J. Almlöf, C. Arrowsmith, A. Lemak, 2014, Biochemical and biophysical research communications.

The crystal structure of hypothetical protein MTH1491 from Methanobacterium thermoautotrophicum

C. Arrowsmith, A. Semesi, V. Saridakis, 2002, Protein science : a publication of the Protein Society.

Fluorescence-Based Methods for Screening Writers and Readers of Histone Methyl Marks

C. Arrowsmith, M. Vedadi, A. Allali-Hassani, 2012, Journal of biomolecular screening.

Design of a fluorescent ligand targeting the S-adenosylmethionine binding site of the histone methyltransferase MLL1.

C. Arrowsmith, S. Houliston, M. Vedadi, 2016, Organic & biomolecular chemistry.

Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response

Amber L. Couzens, M. Tyers, A. Gingras, 2020, Nature Communications.

Small Molecule Antagonists of the Interaction between the Histone Deacetylase 6 Zinc-Finger Domain and Ubiquitin.

F. von Delft, C. Arrowsmith, M. Schapira, 2017, Journal of medicinal chemistry.