P. Chiap

发表

Nonaqueous capillary electrophoretic behavior of 2-aryl propionic acids in the presence of an achiral ionic liquid. A chemometric approach.

Yannis-Nicolas François, A. Varenne, Emilie Juillerat, 2007, Journal of chromatography. A.

Comparison and combination of spectroscopic techniques for the detection of counterfeit medicines.

T. De Beer, P. Chiap, E. Deconinck, 2010, Journal of pharmaceutical and biomedical analysis.

Development of response models for optimising HPLC methods

Philippe Hubert, Patrice Chiap, Walthère Dewé, 2004 .

Harmonization of strategies for the validation of quantitative analytical procedures. A SFSTP proposal--part II.

M Laurentie, P. Chiap, P. Hubert, 2004, Journal of pharmaceutical and biomedical analysis.

An analysis of the SFSTP guide on validation of chromatographic bioanalytical methods: progress and limitations.

P. Chiap, P. Hubert, B. Boulanger, 2003, Journal of pharmaceutical and biomedical analysis.

Harmonization of strategies for the validation of quantitative analytical procedures. A SFSTP proposal--Part I.

M Laurentie, P. Chiap, P. Hubert, 2004, Journal of pharmaceutical and biomedical analysis.

Harmonization of strategies for the validation of quantitative analytical procedures

Patrice Chiap, Walthère Dewé, Bruno Boulanger, 2007 .

The SFSTP guide on the validation of chromatographic methods for drug bioanalysis: from the Washington Conference to the laboratory

Philippe Hubert, Patrice Chiap, Bruno Boulanger, 1999 .

Development and validation of a ultra-high-performance liquid chromatography-UV method for the detection and quantification of erectile dysfunction drugs and some of their analogues found in counterfeit medicines.

P. Chiap, E. Rozet, E. Deconinck, 2011, Journal of chromatography. A.

The transfer of a LC-UV method for the determination of fenofibrate and fenofibric acid in Lidoses: use of total error as decision criterion.

B. Govaerts, P. Chiap, P. Hubert, 2006, Journal of pharmaceutical and biomedical analysis.

Optimization of micro-HPLC peak focusing for the detection and quantification of low hepcidin concentrations.

A. Servais, P. Chiap, M. Fillet, 2011, Journal of separation science.

Nonaqueous capillary electrophoresis method for the enantiomeric purity determination of S-timolol using heptakis(2,3-di-O-methyl-6-O-sulfo)-beta-cyclodextrin: validation using the accuracy profile strategy and estimation of uncertainty.

Serge Rudaz, Philippe Hubert, Patrice Chiap, 2006, Journal of chromatography. A.

Association of two single‐isomer anionic CD in NACE for the chiral and achiral separation of fenbendazole, its sulphoxide and sulphone metabolites: Application to their determination after in vitro metabolism

A. Servais, P. Chiap, M. Fillet, 2010, Electrophoresis.

Enantiomeric separation of basic compounds using heptakis(2,3‐di‐O‐methyl‐6‐O‐sulfo)‐β‐cyclodextrin in combination with potassium camphorsulfonate in nonaqueous capillary electrophoresis: Optimization by means of an experimental design

A. Servais, P. Chiap, P. Hubert, 2004, Electrophoresis.

Generic systems for the enantioseparation of basic drugs in NACE using single-isomer anionic CDs.

A. Servais, P. Chiap, M. Fillet, 2011, Journal of pharmaceutical and biomedical analysis.

Development and validation of a UHPLC-UV method for the detection and quantification of erectile dysfunction drugs and some of their analogues found in counterfeit medicines.

P. Chiap, E. Rozet, P. Sacré, 2011 .

Multivariate optimization approach for the separation of water-soluble vitamins and related compounds by capillary electrophoresis.

P. Chiap, M. Fillet, B. Boulanger, 2000, Biomedical chromatography : BMC.

On‐line coupling of partial filling‐capillary zone electrophoresis with mass spectrometry for the separation of clenbuterol enantiomers

P. Chiap, P. Hubert, J. Crommen, 2001, Electrophoresis.

Determination of albendazole and its main metabolites in ovine plasma by liquid chromatography with dialysis as an integrated sample preparation technique.

P. Chiap, L. Delattre, P. Hubert, 2000, Journal of chromatography. A.

On-line coupling of cyclodextrin mediated nonaqueous capillary electrophoresis to mass spectrometry for the determination of salbutamol enantiomers in urine.

A. Servais, P. Chiap, M. Fillet, 2006, Journal of pharmaceutical and biomedical analysis.

Development of a mass spectrometry method for the determination of a melanoma biomarker, 5-S-cysteinyldopa, in human plasma using solid phase extraction for sample clean-up.

P. Chiap, P. Hubert, E. Rozet, 2007, Journal of chromatography. A.

Automated determination of pirlindole enantiomers in plasma by on-line coupling of a pre-column packed with restricted access material to a chiral liquid chromatographic column.

P. Chiap, P. Hubert, A. Ceccato, 2002, Journal of pharmaceutical and biomedical analysis.

Use of a novel cation-exchange restricted-access material for automated sample clean-up prior to the determination of basic drugs in plasma by liquid chromatography.

P. Chiap, P. Hubert, J. Crommen, 2002, Journal of chromatography. A.

Evaluation of a novel anion-exchange restricted-access sorbent for on-line sample clean-up prior to the determination of acidic compounds in plasma by liquid chromatography.

P. Chiap, P. Hubert, J. Crommen, 2004, Journal of chromatography. A.

Triphenylphosphonium salts of 1,2,4-benzothiadiazine 1,1-dioxides related to diazoxide targeting mitochondrial ATP-sensitive potassium channels.

A. Mouithys-Mickalad, B. Elmoualij, P. Chiap, 2013, Bioorganic & medicinal chemistry letters.

Hydroxylated analogues of ATP-sensitive potassium channel openers belonging to the group of 6- and/or 7-substituted 3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides: toward an improvement in sulfonylurea receptor 1 selectivity and metabolism stability.

A. Servais, P. Chiap, M. Fillet, 2011, Journal of medicinal chemistry.

Coupling of Liquid Chromatography/Tandem Mass Spectrometry and Liquid Chromatography/Solid-Phase Extraction/NMR Techniques for the Structural Identification of Metabolites following In Vitro Biotransformation of SUR1-Selective ATP-Sensitive Potassium Channel Openers

P. Chiap, M. Frédérich, B. Pirotte, 2010, Drug Metabolism and Disposition.

Coupling of LC-MS/MS and LC-SPE-NMR techniques for the structural identification of metabolites following in vitro biotransformation of SUR1-selective KATP channel openers

P. Tullio, P. Chiap, M. Frédérich, 2009 .

A pilot double-blind randomized placebo-controlled study of molsidomine 16 mg once-a-day in patients suffering from stable angina pectoris: correlation between efficacy and over time plasma concentrations

P. Chiap, P. Hubert, J. Crommen, 2003, European Journal of Clinical Pharmacology.

Pharmacological profile and therapeutic potential of BM-573, a combined thromboxane receptor antagonist and synthase inhibitor.

P. Kolh, P. Chiap, B. Lambermont, 2006, Cardiovascular drug reviews.

P-[F]MPPF AND A POTENTIAL METABOLITE IN HUMAN PLASMA

A. Luxen, J. Aerts, A. Plenevaux, 2020 .

Performance evaluation of a MIP for the MISPE-LC determination of p-[18F]MPPF and a potential metabolite in human plasma.

A. Luxen, J. Aerts, A. Plenevaux, 2019, Journal of pharmaceutical and biomedical analysis.

Example of application of the new strategy proposed for the validation of chromatographic bioanalytical methods

Philippe Hubert, Patrice Chiap, Bruno Boulanger, 2000 .

Automated determination of tramadol enantiomers in human plasma using solid-phase extraction in combination with chiral liquid chromatography.

P. Chiap, P. Hubert, A. Ceccato, 1997, Journal of chromatography. B, Biomedical sciences and applications.

Fully automated determination of sulfamethazine in ovine plasma using solid-phase extraction on disposable cartridges and liquid chromatography.

P. Chiap, L. Delattre, P. Hubert, 1993, Journal of chromatography.

Curcumin–cyclodextrin complexes potentiate gemcitabine effects in an orthotopic mouse model of lung cancer

J. Foidart, P. Chiap, B. Evrard, 2012, British Journal of Cancer.

Impurity fingerprints for the identification of counterfeit medicines--a feasibility study.

M. Daszykowski, P. Chiap, E. Deconinck, 2011, Analytica chimica acta.

Liquid chromatographic analysis of local anesthetics in human plasma after sample preparation by on-line dialysis. Optimization by use of experimental design

P. Chiap, P. Hubert, B. Boulanger, 2001 .

Optimization of the LC enantioseparation of chiral pharmaceuticals using cellulose tris(4-chloro-3-methylphenylcarbamate) as chiral selector and polar non-aqueous mobile phases.

A. Servais, P. Chiap, M. Fillet, 2010, Journal of separation science.

Enantioresolution of basic pharmaceuticals using cellulose tris(4-chloro-3-methylphenylcarbamate) as chiral stationary phase and polar organic mobile phases.

A. Servais, P. Chiap, M. Fillet, 2009, Journal of chromatography. A.

Enantiomeric separation of acidic compounds using single‐isomer amino cyclodextrin derivatives in nonaqueous capillary electrophoresis

A. Servais, P. Chiap, M. Fillet, 2006, Electrophoresis.

Enantiomeric purity determination of propranolol by cyclodextrin-modified capillary electrophoresis

P. Chiap, P. Hubert, M. Fillet, 1995 .

Influence of the nature of the electrolyte on the chiral separation of basic compounds in nonaqueous capillary electrophoresis using heptakis(2,3-di-O-methyl-6-O-sulfo)-beta-cyclodextrin.

A. Servais, P. Chiap, P. Hubert, 2005, Journal of chromatography. A.

Strategy for the development of automated methods involving dialysis and trace enrichment as on-line sample preparation for the determination of basic drugs in plasma by liquid chromatography.

P. Chiap, P. Hubert, J. Crommen, 2002, Journal of chromatography. A.

Development and validation of an automated method for the liquid chromatographic determination of sotalol in plasma using dialysis and trace enrichment on a cation-exchange pre-column as on-line sample preparation.

P. Chiap, P. Hubert, A. Ceccato, 2001, Journal of pharmaceutical and biomedical analysis.

Enantioselective determination of oxprenolol in human plasma using dialysis coupled on-line to reversed-phase chiral liquid chromatography.

P. Chiap, P. Hubert, A. Ceccato, 1997, Journal of pharmaceutical and biomedical analysis.

Automated determination of verapamil and norverapamil in human plasma with on-line coupling of dialysis to high-performance liquid chromatography and fluorometric detection.

P. Chiap, P. Hubert, A. Ceccato, 1996, Journal of chromatography. A.

Knowledge-based system for the automated solid-phase extraction of basic drugs from plasma coupled with their liquid chromatographic determination. Application to the biodetermination of beta-receptor blocking agents.

D L Massart, D. Massart, P. Chiap, 1994, Journal of chromatography. A.

New strategy for the validation of chromatographic bioanalytical methods

P. Chiap, P. Hubert, B. Boulanger, 2000 .

Development and validation of a fully automated LC method for the determination of cloxacillin in human plasma using anion exchange restricted access material for sample clean-up.

P. Chiap, P. Hubert, J. Crommen, 2005, Journal of pharmaceutical and biomedical analysis.

Penetration of oxytetracycline into the nasal secretions and relationship between nasal secretions and plasma oxytetracycline concentrations after oral and intramuscular administration in healthy pigs.

P. Chiap, C. Cambier, P. Gustin, 2011, Journal of veterinary pharmacology and therapeutics.

Penetration of enrofloxacin into the nasal secretions and relationship between nasal secretions and plasma enrofloxacin concentrations after intramuscular administration in healthy pigs.

P. Chiap, C. Cambier, P. Gustin, 2010, Journal of veterinary pharmacology and therapeutics.

Optimization of the liquid chromatography enantioseparation of chiral acidic compounds using cellulose tris(3-chloro-4-methylphenylcarbamate) as chiral selector and polar organic mobile phases.

A. Servais, P. Chiap, M. Fillet, 2012, Journal of chromatography. A.

Determination of enantiomeric purity of S-amlodipine by chiral LC with emphasis on reversal of enantiomer elution order.

A. Servais, P. Chiap, M. Fillet, 2011, Journal of separation science.

Oral bioavailability in sheep of albendazole from a suspension and from a solution containing hydroxypropyl-beta-cyclodextrin.

P. Chiap, L. Delattre, B. Evrard, 2002, Journal of controlled release : official journal of the Controlled Release Society.

LC method for the determination of R-timolol in S-timolol maleate: Validation of its ability to quantify and uncertainty assessment.

S. Rudaz, P. Chiap, R. Marini, 2006, Talanta.

Elimination of adsorption effects in the analysis of water-soluble vitamins in pharmaceutical formulations by capillary electrophoresis.

P. Chiap, P. Hubert, M. Fillet, 1999, Journal of chromatography. A.

Performances of a multidimensional on-line SPE-LC-ECD method for the determination of three major catecholamines in native human urine: validation, risk and uncertainty assessments.

P. Chiap, P. Hubert, E. Rozet, 2006, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Development and validation of a high performance liquid chromatographic method for quantitative determination of aporphine alkaloids from different samples of Cassytha filiformis.

Philippe Hubert, Patrice Chiap, Joëlle Quetin-Leclercq, 2004, Planta medica.

Development and validation of a LC method for the enantiomeric purity determination of S-ropivacaine in a pharmaceutical formulation using a recently commercialized cellulose-based chiral stationary phase and polar non-aqueous mobile phase.

A. Servais, P. Chiap, M. Fillet, 2011, Journal of pharmaceutical and biomedical analysis.

Pharmacokinetic study of a new synthetic MMP inhibitor (Ro 28-2653) after IV and oral administration of cyclodextrin solutions.

J. Foidart, P. Chiap, L. Delattre, 2006, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Automated liquid chromatographic determination of atenolol in plasma using dialysis and trace enrichment on a cation-exchange precolumn for sample handling.

P. Chiap, P. Hubert, A. Ceccato, 2000, Journal of chromatography. B, Biomedical sciences and applications.

Validation of a nonaqueous capillary electrophoretic method for the enantiomeric purity determination of R-flurbiprofen using a single-isomer amino cyclodextrin derivative.

A. Servais, P. Chiap, M. Fillet, 2008, Journal of chromatography. A.

Development and validation of a nonaqueous capillary electrophoretic method for the enantiomeric purity determination of a synthetic intermediate of new 3,4-dihydro-2,2-dimethyl-2H-1-benzopyrans using a single-isomer anionic cyclodextrin derivative and an ionic liquid.

D. Villemin, A. Varenne, A. Servais, 2010, Journal of chromatography. A.

Determination of flurbiprofen enantiomers in plasma using a single‐isomer amino cyclodextrin derivative in nonaqueous capillary electrophoresis

A. Servais, P. Chiap, M. Fillet, 2008, Electrophoresis.

Pre-study and in-study validation of a SPE-LC-MS-MS method for the determination of 5-S-cysteinyldopa, a melanoma biomarker, in human plasma.

A. Servais, P. Chiap, A. Rorive, 2011, Talanta.

Development and validation of a high-performance liquid chromatographic method for the determination of cyproterone acetate in human skin.

Philippe Hubert, Patrice Chiap, Jacques Crommen, 2004, Journal of pharmaceutical and biomedical analysis.

Fully automated method for the liquid chromatographic determination of cyproterone acetate in plasma using restricted access material for sample pre-treatment.

P. Chiap, P. Hubert, J. Crommen, 2003, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Fully automated method for the liquid chromatographic-tandem mass spectrometric determination of cyproterone acetate in human plasma using restricted access material for on-line sample clean-up.

P. Chiap, P. Hubert, M. Fillet, 2004, Journal of chromatography. A.

Simultaneous determination of methylphenobarbital enantiomers and phenobarbital in human plasma by on-line coupling of an achiral precolumn to a chiral liquid chromatographic column.

P. Chiap, P. Hubert, A. Ceccato, 1998, Journal of chromatography. A.

LC method for the simultaneous determination of R-timolol and other closely related impurities in S-timolol maleate: Optimization by use of an experimental design

P. Chiap, R. Marini, P. Hubert, 2003 .

Detection of counterfeit Viagra® by Raman microspectroscopy imaging and multivariate analysis.

Patrice Chiap, Jacques Crommen, Thomas De Beer, 2011, Journal of pharmaceutical and biomedical analysis.

Automatic determination of diltiazem and desacetyldiltiazem in human plasma using liquid-solid extraction on disposable cartridges coupled to HPLC--Part I: Optimization of the HPLC system and method validation.

P. Chiap, P. Hubert, J. Crommen, 1991, Journal of pharmaceutical and biomedical analysis.

Optimization of the separation of β-blockers by ion-pair capillary electrophoresis in non-aqueous media using univariate and multivariate approaches

A. Servais, P. Chiap, P. Hubert, 2002 .

Interlaboratory studies on two high-performance liquid chromatographic assays for tylosin (tartrate)

Y. Heyden, D. Massart, E. Roets, 1999 .

Uncertainty assessment from robustness testing applied on an LC assay for R-timolol and other related substances in S-timolol maleate

Y. Heyden, P. Chiap, R. Marini, 2005 .

Interlaboratory study of a liquid chromatography method for erythromycin: determination of uncertainty.

D. Massart, A. Van Schepdael, J. Hoogmartens, 2003, Journal of chromatography. A.

Collaborative study of an liquid chromatographic method for the determination of R-timolol and other related substances in S-timolol maleate

Y. Heyden, J. Hoogmartens, P. Dehouck, 2005 .

Risk-based approach for the transfer of quantitative methods: bioanalytical applications.

P. Chiap, P. Hubert, E. Rozet, 2008, Journal of chromatography. A.

Clinical pharmacokinetics of once-daily molsidomine

P. Chiap, P. Hubert, A. Herchuelz, 2004 .

New fluorinated 1,2,4-benzothiadiazine 1,1-dioxides: discovery of an orally active cognitive enhancer acting through potentiation of the 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors.

L. Danober, P. Chiap, P. Lestage, 2010, Journal of Medicinal Chemistry.

Integrated on-line sample clean-up using cation exchange restricted access sorbent for the LC determination of atropine in human plasma coupled to UV detection.

P. Chiap, P. Hubert, J. Crommen, 2005, Journal of pharmaceutical and biomedical analysis.

Precision study on capillary electrophoresis methods for metacycline

A. Van Schepdael, J. Hoogmartens, R. Gotti, 2006, Electrophoresis.

Using total error as decision criterion in analytical method transfer

Philippe Hubert, Patrice Chiap, Walthère Dewé, 2007 .

Pre-study and in-study validation of an ultra-high pressure LC method coupled to tandem mass spectrometry for off-line determination of oxytetracycline in nasal secretions of healthy pigs.

P. Chiap, E. Rozet, P. Gustin, 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Fully automated electrophoretically mediated microanalysis for CYP1A1 activity monitoring optimized by multivariate approach

A. Servais, P. Chiap, M. Fillet, 2016, Electrophoresis.

Determination of salbutamol enantiomers in human urine using heptakis(2,3‐di‐O‐acetyl‐6‐O‐sulfo)‐β‐cyclodextrin in nonaqueous capillary electrophoresis

A. Servais, P. Chiap, P. Hubert, 2004, Electrophoresis.

Evaluation of some parameters influencing the drug delivery from a dry powder inhalation device using an in vitro model of the horse airways.

P. Chiap, J. Crommen, P. Lekeux, 1997, Veterinary research.

Liquid chromatographic determination of enrofloxacin in nasal secretions and plasma of healthy pigs using restricted access material for on-line sample clean-up.

P. Chiap, P. Hubert, E. Rozet, 2008, Journal of chromatography. A.

Fully automated LC method for the determination of sotalol in human plasma using restricted access material with cation exchange properties for sample clean-up.

P. Chiap, P. Hubert, J. Crommen, 2003, Journal of pharmaceutical and biomedical analysis.

Determination of verapamil and norverapamil in human plasma by liquid chromatography: comparison between a liquid-liquid extraction procedure and an automated liquid-solid extraction method for sample preparation.

P. Chiap, P. Hubert, A. Ceccato, 1992, Journal of pharmaceutical and biomedical analysis.

Automatic determination of diltiazem and desacetyldiltiazem in human plasma using liquid-solid extraction on disposable cartridges coupled to HPLC--Part II: Optimization of liquid-solid extraction.

P. Chiap, P. Hubert, J. Crommen, 1991, Journal of pharmaceutical and biomedical analysis.