P. Tonge

发表

Roles of tyrosine 158 and lysine 165 in the catalytic mechanism of InhA, the enoyl-ACP reductase from Mycobacterium tuberculosis.

S. Parikh, D. Moynihan, G. Xiao, 1999, Biochemistry.

Drug-target residence time: critical information for lead optimization.

P. Tonge, Hao Lu, 2010, Current opinion in chemical biology.

Evaluating the Contribution of Transition-State Destabilization to Changes in the Residence Time of Triazole-Based InhA Inhibitors.

P. Tonge, C. Kisker, R. Slayden, 2017, Journal of the American Chemical Society.

Drug–Target Kinetics in Drug Discovery

P. Tonge, 2017, ACS chemical neuroscience.

Slow-onset inhibition of the FabI enoyl reductase from francisella tularensis: residence time and in vivo activity.

P. Tonge, C. Kisker, R. Slayden, 2009, ACS chemical biology.

crystal structure of M. tuberculosis InhA inhibited by PT70

P. Tonge, C. Kisker, Lauren A. Spagnuolo, 2017 .

Inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosis, by triclosan and isoniazid.

S. Parikh, G. Xiao, P. Tonge, 2000, Biochemistry.

during Infection to Bacterial Viability and Is Expressed Essential Carrier Protein Reductase Gene Is The Francisella tularensis FabI Enoyl-Acyl

P. Tonge, K. Brookman, C. Kingry, 2014 .

Rational Design of Broad Spectrum Antibacterial Activity Based on a Clinically Relevant Enoyl-Acyl Carrier Protein (ACP) Reductase Inhibitor*

C. Sotriffer, P. Tonge, C. Kisker, 2014, The Journal of Biological Chemistry.

Modulating the Spectrum of FabI Inhibition by Pyridones 1 Rational Design of Broad-Spectrum Antibacterial Activity based on a Clinically Relevant Enoyl-ACP Reductase Inhibitor *

C. Sotriffer, P. Tonge, C. Kisker, 2014 .

The Francisella tularensis FabI Enoyl-Acyl Carrier Protein Reductase Gene Is Essential to Bacterial Viability and Is Expressed during Infection

P. Tonge, K. Brookman, R. Slayden, 2012, Journal of bacteriology.

The Kinetics and Thermodynamics of Staphylococcus aureus FabI Inhibition

P. Tonge, Eleanor K H Allen, Andrew Chang, 2015 .

Functional dynamics of a single tryptophan residue in a BLUF protein revealed by fluorescence spectroscopy

G. M. Greetham, P. Tonge, S. Meech, 2020, Scientific Reports.

Synthesis of 4-phenoxybenzamide adenine dinucleotide as NAD analogue with inhibitory activity against enoyl-ACP reductase (InhA) of Mycobacterium tuberculosis.

P. Tonge, Taesoo Kim, L. Bonnac, 2007, Bioorganic & medicinal chemistry letters.

Time‐Dependent Diaryl Ether Inhibitors of InhA: Structure–Activity Relationship Studies of Enzyme Inhibition, Antibacterial Activity, and in vivo Efficacy

M. García-Díaz, P. Tonge, C. Simmerling, 2014, ChemMedChem.

Mechanism of the intramolecular Claisen condensation reaction catalyzed by MenB, a crotonase superfamily member.

M. García-Díaz, P. Tonge, C. Kisker, 2011, Biochemistry.

Another brick in the wall

P. Tonge, 2000, Nature Structural Biology.

Vibrational assignment of the ultrafast infrared spectrum of the photoactivatable flavoprotein AppA.

A. Bacher, G. M. Greetham, I. Clark, 2012, The journal of physical chemistry. B.

Radiosynthesis and biological evaluation of a novel enoyl-ACP reductase inhibitor for Staphylococcus aureus.

J. Fowler, P. Tonge, J. Hooker, 2014, European journal of medicinal chemistry.

Exploring the chemical space of 1,2,3-triazolyl triclosan analogs for discovery of new antileishmanial chemotherapeutic agents.

P. Hoffmann, B. Tekwani, P. Tonge, 2020, RSC medicinal chemistry.

Stereoselectivity of enoyl-CoA hydratase results from preferential activation of one of two bound substrate conformers.

Peter J Tonge, Adrian Whitty, A. Whitty, 2002, Chemistry & biology.

Electronic rearrangement induced by substrate analog binding to the enoyl-CoA hydratase active site: evidence for substrate activation.

P. Tonge, P. Carey, V. Anderson, 1994, Biochemistry.

Enoyl-coenzyme A hydratase-catalyzed exchange of the alpha-protons of coenzyme A thiol esters: a model for an enolized intermediate in the enzyme-catalyzed elimination?

P. Tonge, V. Anderson, R. D'Ordine, 1994, Biochemistry.

Molecular structures of cis- and trans-S-ethyl thiocrotonate. A combined vibrational spectroscopic and ab initio SCF-MO study

P. Tonge, P. Carey, R. Fausto, 1994 .

Localized electron polarization in a substrate analog binding to the active site of enoyl‐CoA hydratase: Raman spectroscopic and conformational analyses of rotamers of hexadienoyl thiolesters

P. Tonge, P. Carey, V. Anderson, 1995 .

Raman study of the polarizing forces promoting catalysis in 4-chlorobenzoate-CoA dehalogenase.

P. Tonge, D. Dunaway-Mariano, P. Carey, 1997, Biochemistry.

Structure of Hexadienoyl-CoA Bound to Enoyl-CoA Hydratase Determined by Transferred Nuclear Overhauser Effect Measurements: Mechanistic Predictions Based on the X-ray Structure of 4-(Chlorobenzoyl)-CoA Dehalogenase†

D. Raleigh, P. Tonge, V. Anderson, 1997 .

Role of glutamate 144 and glutamate 164 in the catalytic mechanism of enoyl-CoA hydratase.

P. Tonge, V. Anderson, Y. Feng, 1999, Biochemistry.

Stereospecificity of the Reaction Catalyzed by Enoyl-CoA Hydratase

P. Tonge, Yuguo Feng, H. Hofstein, 2000 .

Involvement of glycine 141 in substrate activation by enoyl-CoA hydratase.

P. Tonge, A. Bell, J. Wu, 2001, Biochemistry.

Effect of mutagenesis on the stereochemistry of enoyl-CoA hydratase.

P. Tonge, Yuguo Feng, H. Hofstein, 2002, Biochemistry.

Efficacy Target of a Novel Chemotherapeutic with Growth and Is the In Vivo Essential for Carrier Protein Reductase FabI 1 Is The Burkholderia pseudomallei Enoyl-Acyl

Herbert, P. Tonge, R. Slayden, 2014 .

The Burkholderia pseudomallei Enoyl-Acyl Carrier Protein Reductase FabI1 Is Essential for In Vivo Growth and Is the Target of a Novel Chemotherapeutic with Efficacy

P. Tonge, H. Schweizer, R. Slayden, 2013, Antimicrobial Agents and Chemotherapy.

Site Specific Protein Dynamics Probed by Ultrafast Infrared Spectroscopy of a Noncanonical Amino Acid.

G. M. Greetham, I. Sazanovich, P. Tonge, 2019, The journal of physical chemistry. B.

Pharmacokinetic and Pharmacodynamics Relationships

P. Tonge, F. Daryaee, Zhuo Zhang, 2017 .

Variation in LOV Photoreceptor Activation Dynamics Probed by Time-Resolved Infrared Spectroscopy.

A. Bacher, G. M. Greetham, I. Sazanovich, 2018, Biochemistry.

Synthesis and in vitro antimycobacterial activity of B-ring modified diaryl ether InhA inhibitors.

Peter J Tonge, P. Tonge, F. Johnson, 2008, Bioorganic & medicinal chemistry letters.

Rationalizing the Binding Kinetics for the Inhibition of the Burkholderia pseudomallei FabI1 Enoyl-ACP Reductase.

P. Tonge, C. Kisker, R. Slayden, 2017, Biochemistry.

Thiolactomycin-Based Inhibitors of Bacterial β-Ketoacyl-ACP Synthases with in Vivo Activity.

P. Tonge, R. Slayden, Susan E. Knudson, 2016, Journal of medicinal chemistry.

Structure of the Yersinia pestis FabV enoyl-ACP reductase and its interaction with two 2-pyridone inhibitors.

C. Sotriffer, P. Tonge, C. Kisker, 2012, Structure.

Inhibition of the bacterial enoyl reductase FabI by triclosan: a structure-reactivity analysis of FabI inhibition by triclosan analogues.

P. Tonge, C. Simmerling, F. Johnson, 2004, Journal of medicinal chemistry.

Targeting FtsZ for antituberculosis drug discovery: noncytotoxic taxanes as novel antituberculosis agents.

T. Kirikae, P. Tonge, F. Kirikae, 2006, Journal of medicinal chemistry.

Structure-activity studies of the inhibition of FabI, the enoyl reductase from Escherichia coli, by triclosan: kinetic analysis of mutant FabIs.

P. Tonge, L. Hedstrom, A. Bell, 2003, Biochemistry.

Structure-kinetic relationships that control the residence time of drug-target complexes: insights from molecular structure and dynamics.

P. Tonge, Hao Lu, James N Iuliano, 2018, Current opinion in chemical biology.

Computer-aided identification, synthesis, and biological evaluation of novel inhibitors for botulinum neurotoxin serotype A.

S. Swaminathan, P. Tonge, T. E. Balius, 2015, Bioorganic & medicinal chemistry.

Rational Modulation of the Induced-Fit Conformational Change for Slow-Onset Inhibition in Mycobacterium tuberculosis InhA.

M. García-Díaz, P. Tonge, C. Simmerling, 2015, Biochemistry.

Thiolactomycin-based β-Ketoacyl-AcpM Synthase A (KasA) Inhibitors

P. Tonge, C. Simmerling, F. Picart, 2013, The Journal of Biological Chemistry.

Characterizing septum inhibition in Mycobacterium tuberculosis for novel drug discovery.

D. Raleigh, P. Tonge, C. Kisker, 2008, Tuberculosis.

Radiosynthesis and bioimaging of the tuberculosis chemotherapeutics isoniazid, rifampicin and pyrazinamide in baboons.

J. Fowler, P. Tonge, C. Shea, 2010, Journal of medicinal chemistry.

Discovery of anti-TB agents that target the cell-division protein FtsZ.

P. Tonge, Kunal Kumar, R. Slayden, 2010, Future medicinal chemistry.

FtsZ: a novel target for tuberculosis drug discovery.

T. Kirikae, P. Tonge, R. Slayden, 2007, Current topics in medicinal chemistry.

Positron Emission Tomography Imaging with 2-[18F]F-p-Aminobenzoic Acid Detects Staphylococcus aureus Infections and Monitors Drug Response

P. Tonge, P. Smith-Jones, F. Daryaee, 2018, ACS infectious diseases.

The biodistribution of 5-[18F]fluoropyrazinamide in Mycobacterium tuberculosis-infected mice determined by positron emission tomography

P. Tonge, P. Smith-Jones, F. Daryaee, 2017, PloS one.

Determination of [11C]Rifampin Pharmacokinetics within Mycobacterium tuberculosis-Infected Mice by Using Dynamic Positron Emission Tomography Bioimaging

K. Dooley, D. Holt, P. Tonge, 2015, Antimicrobial Agents and Chemotherapy.

Radiolabelling and positron emission tomography of PT70, a time-dependent inhibitor of InhA, the Mycobacterium tuberculosis enoyl-ACP reductase.

J. Fowler, P. Tonge, J. Hooker, 2015, Bioorganic & medicinal chemistry letters.

Rational modulation of the induced-fit conformational change for slow-onset inhibition in M. tuberculosis InhA

M. García-Díaz, P. Tonge, C. Simmerling, 2016 .

Antibacterial Activity and Mode of Action of a Sulfonamide-Based Class of Oxaborole Leucyl-tRNA-Synthetase Inhibitors.

P. Tonge, J. Merino, S. Walker, 2019, ACS infectious diseases.

UNLOCKING THE SECRETS OF ENZYME POWER USING RAMAN SPECTROSCOPY

P. Tonge, P. Carey, 1995 .

Asparagine deprivation mediated by Salmonella asparaginase causes suppression of activation‐induced T cell metabolic reprogramming

E. Chen, A. Koller, P. Tonge, 2016, Journal of leukocyte biology.

Fourier-transform infra-red studies of the alkaline isomerization of mitochondrial cytochrome c and the ionization of carboxylic acids.

C. Wharton, P. Tonge, G. Moore, 1989, Biochemical Journal.

Rational Optimization of Diphenyl Ether Binding Kinetics to the Enoyl-ACP Reductase FabI1 from Burkholderia pseudomallei

P. Tonge, C. Kisker, R. Slayden, 2017 .

A [32P]-NAD+-based method to identify and quantitate long residence time enoyl-ACP reductase inhibitors

Ch Lai, P. Tonge, Lauren A. Spagnuolo, 2015 .

Mycobacterium Tuberculosis Condensing Enzyme and Drug Target from Mycolic Acid Precursors by KasA , a Structural Basis for the Recognition of Protein Structure and Folding

Martin J. Mueller, P. Tonge, C. Kisker, 2013 .

FACILE CHARACTERIZATION OF THE SPECTRA OF cis AND trans PHOTOISOMERS IN A MIXTURE OF ACYL‐ENZYMES BY RAMAN DIFFERENCE SPECTROSCOPY

P. Tonge, P. Carey, Munsok Kim, 1994 .

Structural and functional studies of fatty acyl adenylate ligases from E. coli and L. pneumophila.

J. M. Sauder, S. Burley, S. Swaminathan, 2010, Journal of molecular biology.

Structure and mechanism of MbtI, the salicylate synthase from Mycobacterium tuberculosis.

P. Tonge, C. Kisker, S. Kolappan, 2007, Biochemistry.

A Long Residence Time Enoyl-Reductase Inhibitor Explores an Extended Binding Region with Isoenzyme-Dependent Tautomer Adaptation and Differential Substrate-Binding Loop Closure.

C. Sotriffer, B. Merget, P. Tonge, 2021, ACS infectious diseases.

Vibrational spectroscopy of flavoproteins.

P. Tonge, J. French, James N. Iuliano, 2019, Methods in enzymology.

Substituted Diphenyl Ethers as a Novel Chemotherapeutic Platform against Burkholderia pseudomallei

P. Tonge, H. Schweizer, R. Slayden, 2013, Antimicrobial Agents and Chemotherapy.

Impact of Target Turnover on the Translation of Drug-Target Residence Time to Time-Dependent Antibacterial Activity.

Nan Wang, P. Tonge, J. Haley, 2021, ACS infectious diseases.

Raman, resonance Raman and FTIR spectroscopic studies of enzyme-substrate complexes

P. Tonge, P. Carey, 1993 .

A Methyl 4-Oxo-4-phenylbut-2-enoate with in Vivo Activity against MRSA that Inhibits MenB in the Bacterial Menaquinone Biosynthesis Pathway.

P. Tonge, F. Daryaee, B. Ruzsicska, 2016, ACS infectious diseases.

Lysine 190 is the catalytic base in MenF, the menaquinone-specific isochorismate synthase from Escherichia coli: implications for an enzyme family.

P. Tonge, C. Kisker, S. Kolappan, 2007, Biochemistry.

Structure-Kinetic Relationship Studies for the Development of Long Residence Time LpxC Inhibitors.

P. Tonge, Yong Li, F. Daryaee, 2022, Journal of medicinal chemistry.

Mechanism and inhibition of the FabV enoyl-ACP reductase from Burkholderia mallei.

P. Tonge, Hao Lu, 2010, Biochemistry.

Positron Emission Tomography Imaging of Staphylococcus aureus Infection Using a Nitro-Prodrug Analog of 2-[18F]F-p-Aminobenzoic Acid.

P. Tonge, P. Smith-Jones, F. Daryaee, 2020, ACS infectious diseases.

A Raman-active competitive inhibitor of OMP decarboxylase.

R. Wolfenden, P. Tonge, A. Bell, 2006, Bioorganic chemistry.

Synthesis of crotonyl-oxyCoA: a mechanistic probe of the reaction catalyzed by enoyl-CoA hydratase.

P. Tonge, Y. Feng, M. Dai, 2001, Journal of the American Chemical Society.

Rotational isomerism in CH3C(S)SCH3 and CH3C(S)SCH2CH3: a combined vibrational spectroscopic and ab initio study

P. Tonge, P. Carey, R. Fausto, 1994 .

A Slow, Tight Binding Inhibitor of InhA, the Enoyl-Acyl Carrier Protein Reductase from Mycobacterium tuberculosis*

Peter J Tonge, Nina Liu, P. Tonge, 2010, The Journal of Biological Chemistry.

Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

P. Tonge, R. Slayden, Susan E. Knudson, 2010, Bioorganic & medicinal chemistry letters.

Antitubercular activity of 1,2,3-triazolyl fatty acid derivatives.

P. Tonge, H. R. Morbidoni, G. Labadié, 2017, European journal of medicinal chemistry.

Observation of excited-state proton transfer in green fluorescent protein using ultrafast vibrational spectroscopy.

P. Matousek, M. Towrie, P. Tonge, 2005, Journal of the American Chemical Society.

Resonance Raman and absorption spectroscopic characterization of the chemically engineered enzyme thiolsubtilisin; comparison with a natural thiolenzyme

P. Tonge, Paul R. Carrey, 1989 .

Direct observation of the titration of substrate carbonyl groups in the active site of alpha-chymotrypsin by resonance Raman spectroscopy.

P. Tonge, P. Carey, 1989, Biochemistry.

Active site heterogeneity in dimethyl sulfoxide reductase from Rhodobacter capsulatus revealed by Raman spectroscopy.

P. Tonge, A. McEwan, J. P. Ridge, 2001, Biochemistry.

Targeting InhA, the FASII enoyl-ACP reductase: SAR studies on novel inhibitor scaffolds.

Peter J Tonge, P. Tonge, Pan Pan, 2012, Current topics in medicinal chemistry.

Structural basis and mechanism of enoyl reductase inhibition by triclosan.

S. Parikh, G. Xiao, P. Tonge, 1999, Journal of molecular biology.

Length of the acyl carbonyl bond in acyl-serine proteases correlates with reactivity.

P. Tonge, P. Carey, 1990, Biochemistry.

Novel trisubstituted benzimidazoles, targeting Mtb FtsZ, as a new class of antitubercular agents.

P. Tonge, Kunal Kumar, R. Slayden, 2011, Journal of medicinal chemistry.

Quantifying the Interactions between Biomolecules: Guidelines for Assay Design and Data Analysis

Peter J Tonge, P. Tonge, 2019, ACS infectious diseases.

A Machine Learning-Based Method To Improve Docking Scoring Functions and Its Application to Drug Repurposing

Philip E. Bourne, Peter J. Tonge, Lei Xie, 2011, J. Chem. Inf. Model..

The isoniazid-NAD adduct is a slow, tight-binding inhibitor of InhA, the Mycobacterium tuberculosis enoyl reductase: Adduct affinity and drug resistance

Peter J. Tonge, Richa Rawat, Adrian Whitty, 2003, Proceedings of the National Academy of Sciences of the United States of America.

CHAPTER 4:Narrow Spectrum Antibacterial Agents

P. Tonge, S. Fisher, Lauren A. Spagnuolo, 2017 .

Crystal Structure of Mycobacterium tuberculosis MenB, a Key Enzyme in Vitamin K2 Biosynthesis*

Peter J Tonge, Karsten Theis, P. Tonge, 2003, Journal of Biological Chemistry.

Structural Basis for the Recognition of Mycolic Acid Precursors by KasA, a Condensing Enzyme and Drug Target from Mycobacterium Tuberculosis *

Martin J. Mueller, P. Tonge, C. Kisker, 2013, The Journal of Biological Chemistry.

Resonance Raman spectroscopic and kinetic consequences of a nitrogen ... sulphur enzyme-substrate contact in a series of dithioacylpapains.

P. Tonge, P. Carey, A. C. Storer, 1992, Biophysical journal.

Potential of lichen secondary metabolites against Plasmodium liver stage parasites with FAS-II as the potential target.

A. Tarun, P. Tonge, M. Zloh, 2013, Journal of natural products.

Substrate Recognition by the Human Fatty-acid Synthase*

P. Tonge, W. Miller, C. Gordon, 2005, Journal of Biological Chemistry.

Identification of the vibrational marker of tyrosine cation radical using ultrafast transient infrared spectroscopy of flavoprotein systems

G. M. Greetham, I. Clark, P. Tonge, 2021, Photochemical & Photobiological Sciences.

Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli.

P. Tonge, R. Perozzo, D. Taşdemir, 2007, Bioorganic & Medicinal Chemistry.

Mechanism and inhibition of saFabI, the enoyl reductase from Staphylococcus aureus.

Christopher F Stratton, T. Kirikae, P. Tonge, 2008, Biochemistry.

Inhibitors of FabI, an enzyme drug target in the bacterial fatty acid biosynthesis pathway.

P. Tonge, Hao Lu, Hao Lu, 2008, Accounts of chemical research.

Ultrafast transient mid IR to visible spectroscopy of fully reduced flavins.

G. M. Greetham, M. Towrie, P. Tonge, 2011, Physical chemistry chemical physics : PCCP.

Unraveling the Photoactivation Mechanism of a Light-Activated Adenylyl Cyclase Using Ultrafast Spectroscopy Coupled with Unnatural Amino Acid Mutagenesis

András Lukács, G. M. Greetham, M. Towrie, 2022, ACS chemical biology.

Structural basis for the regulation of biofilm formation and iron uptake in A. baumannii by the blue-light using photoreceptor, BlsA.

P. Tonge, J. French, S. Walker, 2020, ACS infectious diseases.

Chemistry of enzyme–substrate complexes revealed by resonance Raman spectroscopy

P. Tonge, P. Carey, 1990 .

Striking changes observed in key acyl-enzyme linkages by resonance Raman experiments near 77 K

P. Tonge, P. Carey, B. Ruzsicska, 1989 .

Ultraviolet resonance Raman spectroscopy of a highly specific acyl-papain

C. Wharton, P. Tonge, R. Hester, 1985 .

Diacyltransferase Activity and Chain Length Specificity of Mycobacterium tuberculosis PapA5 in the Synthesis of Alkyl β-Diol Lipids.

Anil K. Shukla, P. Tonge, T. Metz, 2015, Biochemistry.

Vibrationally resolved photoabsorption spectroscopy of red fluorescent protein chromophore anions.

P. Tonge, A. Bell, S. Nielsen, 2003, Physical review letters.

CNS Anticancer Drug Discovery and Development Conference White Paper.

D. Berry, J. Sarkaria, P. Wen, 2015, Neuro-oncology.

Translating slow-binding inhibition kinetics into cellular and in vivo effects.

Peter J Tonge, Virna J A Schuck, Zhiping You, 2015, Nature chemical biology.

Gas-phase absorption properties of DsRed model chromophores

P. Tonge, A. Bell, S. Nielsen, 2003 .

Probing the ground state structure of the green fluorescent protein chromophore using Raman spectroscopy.

P. Tonge, R. Wachter, A. Bell, 2000, Biochemistry.

An alternate proton acceptor for excited-state proton transfer in green fluorescent protein: rewiring GFP.

P. Tonge, S. Meech, K. Ronayne, 2008, Journal of the American Chemical Society.

Stable Analogues of OSB‐AMP: Potent Inhibitors of MenE, the o‐Succinylbenzoate‐CoA Synthetase from Bacterial Menaquinone Biosynthesis

Derek S. Tan, S. Swaminathan, P. Tonge, 2012, Chembiochem : a European journal of chemical biology.

Crystal structures of Mycobacterium tuberculosis KasA show mode of action within cell wall biosynthesis and its inhibition by thiolactomycin.

P. Tonge, C. Kisker, S. Luckner, 2009, Structure.

Author ' s personal copy Crystal Structure and Raman Studies of dsFP 483 , a Cyan Fluorescent Protein from Discosoma striata

P. Tonge, R. Wachter, Meitian Wang, 2008 .

Substituted diphenyl ethers as a broad-spectrum platform for the development of chemotherapeutics for the treatment of tularaemia.

Peter J Tonge, P. Tonge, R. Slayden, 2009, The Journal of antimicrobial chemotherapy.

Isotopic labeling and normal-mode analysis of a model green fluorescent protein chromophore

Peter J. Tonge, P. Tonge, Xiang He, 2002 .

Targeting Fatty Acid Biosynthesis for the Development of Novel Chemotherapeutics against Mycobacterium tuberculosis: Evaluation of A-Ring-Modified Diphenyl Ethers as High-Affinity InhA Inhibitors

Peter J. Tonge, Richard A. Slayden, P. Tonge, 2007, Antimicrobial Agents and Chemotherapy.

Fatty Acid Biosynthesis and Oxidation

P. Tonge, Huaning Zhang, Carl A. Machutta, 2010 .

Substrate recognition by β-ketoacyl-ACP synthases.

P. Tonge, Xujie Zhang, Andrew Chang, 2011, Biochemistry.

Structure-Based Design, Synthesis, and Biological Evaluation of Non-Acyl Sulfamate Inhibitors of the Adenylate-Forming Enzyme MenE

Derek S. Tan, P. Tonge, J. French, 2019, Biochemistry.

Structure-Based Design, Synthesis, and Biological Evaluation ofNon-Acyl Sulfamate Inhibitors of the Adenylate-Forming EnzymeMenE

Derek S. Tan, P. Tonge, J. French, 2019 .

Light-driven decarboxylation of wild-type green fluorescent protein.

Peter J Tonge, P. Tonge, R. Wachter, 2003, Journal of the American Chemical Society.

Pharmacokinetic-pharmacodynamic models that incorporate drug-target binding kinetics.

P. Tonge, F. Daryaee, 2019, Current opinion in chemical biology.

CNS Anticancer Drug Discovery and Development: 2016 conference insights.

P. Tonge, V. Levin, W. Weiss, 2017, CNS oncology.

Proteins in Action: Femtosecond to Millisecond Structural Dynamics of a Photoactive Flavoprotein

G. M. Greetham, I. Clark, M. Towrie, 2013, Journal of the American Chemical Society.

Development of modern InhA inhibitors to combat drug resistant strains of Mycobacterium tuberculosis.

Peter J Tonge, P. Tonge, C. Kisker, 2007, Current topics in medicinal chemistry.

Staphylococcus aureus FabI: inhibition, substrate recognition, and potential implications for in vivo essentiality.

P. Tonge, C. Kisker, Hao Lu, 2012, Structure.

A Virtual Screen Discovers Novel, Fragment-Sized Inhibitors of Mycobacterium tuberculosis InhA

Arthur J. Olson, Sean Ekins, Stefano Forli, 2015, J. Chem. Inf. Model..

Correlating Drug-Target Residence Time and Post-Antibiotic Effect: Insight into Target Vulnerability.

P. Tonge, F. Daryaee, S. Davoodi, 2020, ACS infectious diseases.

Correlating drug–target kinetics and in vivo pharmacodynamics: long residence time inhibitors of the FabI enoyl-ACP reductase

C. Sotriffer, P. Tonge, C. Kisker, 2016, Chemical science.

Inhibiting enoyl-ACP reductase (FabI) across pathogenic microorganisms by linear sesquiterpene lactones from Anthemis auriculata.

P. Tonge, R. Perozzo, S. Franzblau, 2008, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Electron transfer quenching in light adapted and mutant forms of the AppA BLUF domain.

G. M. Greetham, M. Towrie, P. Tonge, 2015, Faraday discussions.

BLUF Domain Function Does Not Require a Metastable Radical Intermediate State

Peter J. Tonge, Kiri Addison, Stephen R. Meech, 2014, Journal of the American Chemical Society.

Drug Discovery Using Chemical Systems Biology: Repositioning the Safe Medicine Comtan to Treat Multi-Drug and Extensively Drug Resistant Tuberculosis

Philip E. Bourne, Peter J. Tonge, Lei Xie, 2009, PLoS Comput. Biol..

An ordered water channel in Staphylococcus aureus FabI: unraveling the mechanism of substrate recognition and reduction.

C. Sotriffer, B. Merget, P. Tonge, 2015, Biochemistry.

Selectivity of Pyridone- and Diphenyl Ether-Based Inhibitors for the Yersinia pestis FabV Enoyl-ACP Reductase.

Ch Lai, P. Tonge, C. Simmerling, 2016, Biochemistry.

A Structural and Energetic Model for the Slow-Onset Inhibition of the Mycobacterium tuberculosis Enoyl-ACP Reductase InhA

Peter J. Tonge, Carlos Simmerling, Miguel Garcia-Diaz, 2014, ACS chemical biology.

Ultrafast vibrational spectroscopy of the flavin chromophore.

P. Tonge, S. Meech, Minako Kondo, 2006, The journal of physical chemistry. B.

Direct inhibitors of InhA are active against Mycobacterium tuberculosis

Paul W Smith, K. Kuhen, P. Tonge, 2015, Science Translational Medicine.

Excited State Vibrations of Isotopically Labeled FMN Free and Bound to a Light-Oxygen-Voltage (LOV) Protein.

A. Bacher, P. Tonge, M. Fischer, 2020, The journal of physical chemistry. B.

Functional dynamics of a single tryptophan residue in a BLUF protein revealed by fluorescence spectroscopy

G. M. Greetham, P. Tonge, S. Meech, 2020, Scientific Reports.

Femtosecond stimulated Raman study of the photoactive flavoprotein AppABLUF

P. Tonge, S. Meech, Christopher R. Hall, 2017 .

Femtosecond to Millisecond Dynamics of Light Induced Allostery in the Avena sativa LOV Domain.

A. Bacher, G. M. Greetham, I. Sazanovich, 2017, The journal of physical chemistry. B.

Ultrafast Structural Dynamics of BlsA, a Photoreceptor from the Pathogenic Bacterium Acinetobacter baumannii

A. Bacher, G. M. Greetham, I. Clark, 2013, The journal of physical chemistry letters.

Photoexcitation of the blue light using FAD photoreceptor AppA results in ultrafast changes to the protein matrix.

G. M. Greetham, I. Clark, M. Towrie, 2011, Journal of the American Chemical Society.

Ultrafast infrared spectroscopy of an isotope-labeled photoactivatable flavoprotein.

A. Bacher, G. M. Greetham, I. Clark, 2011, Biochemistry.

Ultrafast structural dynamics in BLUF domains: transient infrared spectroscopy of AppA and its mutants.

Peter J Tonge, Jérôme Nappa, P. Tonge, 2007, Journal of the American Chemical Society.

Probing hydrogen-bonding interactions in the active site of medium-chain acyl-CoA dehydrogenase using Raman spectroscopy.

P. Tonge, A. Bell, M. Stankovich, 2003, Biochemistry.

Resonance Raman and Fourier transform infrared spectroscopic studies of the acyl carbonyl group in [3-(5-methyl-2-thienyl)acryloyl]chymotrypsin: evidence for artifacts in the spectra obtained by both techniques.

C. Wharton, P. Tonge, P. Carey, 1991, Biochemistry.

Excited State Resonance Raman of Flavin Mononucleotide: Comparison of Theory and Experiment.

András Lukács, P. Tonge, S. Meech, 2021, The journal of physical chemistry. A.

Excited state structure and dynamics of the neutral and anionic flavin radical revealed by ultrafast transient mid-IR to visible spectroscopy.

G. M. Greetham, M. Towrie, P. Tonge, 2012, The journal of physical chemistry. B.

Slow Onset Inhibition of Bacterial β-Ketoacyl-acyl Carrier Protein Synthases by Thiolactomycin*

P. Tonge, C. Simmerling, C. Kisker, 2009, The Journal of Biological Chemistry.

Mechanism-based inhibitors of MenE, an acyl-CoA synthetase involved in bacterial menaquinone biosynthesis.

Derek S. Tan, P. Tonge, Huaning Zhang, 2008, Bioorganic & medicinal chemistry letters.

Photoactivation of the BLUF Protein PixD Probed by the Site-Specific Incorporation of Fluorotyrosine Residues.

G. M. Greetham, M. Towrie, P. Tonge, 2017, Journal of the American Chemical Society.

Mechanism of the AppABLUF Photocycle Probed by Site-Specific Incorporation of Fluorotyrosine Residues: Effect of the Y21 pKa on the Forward and Reverse Ground-State Reactions.

G. M. Greetham, I. Clark, M. Towrie, 2016, Journal of the American Chemical Society.

FTIR studies of hydrogen bonding between α,β-unsaturated esters and alcohols

P. Tonge, P. Carey, R. Fausto, 1996 .

Forces, bond lengths, and reactivity: fundamental insight into the mechanism of enzyme catalysis.

P. Tonge, P. Carey, Paul R. Carey, 1992, Biochemistry.

Transient IR study of Blue Light Sensing Proteins

András Lukács, G. M. Greetham, M. Towrie, 2013 .

Structural Basis for the Recognition of Mycolic Acid Precursors by KasA, a Condensing Enzyme and Drug Target

Martin J. Mueller, P. Tonge, C. Kisker, 2013 .

Mechanism and inhibition of the FabI enoyl-ACP reductase from Burkholderia pseudomallei.

P. Tonge, R. Slayden, K. England, 2011, The Journal of antimicrobial chemotherapy.

Unraveling the Mechanism of a LOV Domain Optogenetic Sensor: A Glutamine Lever Induces Unfolding of the Jα Helix

K. Gardner, J. Toettcher, G. M. Greetham, 2020, bioRxiv.

Structure of hexadienoyl-CoA bound to enoyl-CoA hydratase determined by transferred nuclear Overhauser effect measurements: mechanistic predictions based on the X-ray structure of 4-(chlorobenzoyl)-CoA dehalogenase.

D. Raleigh, P. Tonge, V. Anderson, 1997, Biochemistry.

Heterobivalent Inhibitors of Acetyl-CoA Carboxylase: Drug Target Residence Time and Time-Dependent Antibacterial Activity.

Nan Wang, P. Tonge, Lauren A. Spagnuolo, 2022, Journal of medicinal chemistry.

A quantitative mechanistic PK/PD model directly connects Btk target engagement and in vivo efficacy† †Electronic supplementary information (ESI) available: Derivation of PK/PD models, supplemental methods, analytical data. See DOI: 10.1039/c6sc03306g Click here for additional data file.

P. Tonge, S. Fisher, F. Daryaee, 2017, Chemical science.

A [(32)P]NAD(+)-based method to identify and quantitate long residence time enoyl-acyl carrier protein reductase inhibitors.

Ch Lai, P. Tonge, Lauren A. Spagnuolo, 2015, Analytical biochemistry.

Rational optimization of drug-target residence time: insights from inhibitor binding to the Staphylococcus aureus FabI enzyme-product complex.

Peter J. Tonge, Christoph A. Sotriffer, Weixuan Yu, 2013, Biochemistry.

Excited state dynamics in the green fluorescent protein

P. Tonge, S. Meech, 2009 .

Structure of Acyl Carrier Protein Bound to FabI, the FASII Enoyl Reductase from Escherichia coli*

Christopher F Stratton, P. Tonge, C. Simmerling, 2006, Journal of Biological Chemistry.

High affinity InhA inhibitors with activity against drug-resistant strains of Mycobacterium tuberculosis.

Peter J Tonge, Christopher F Stratton, P. Tonge, 2006, ACS chemical biology.

Formulation studies of InhA inhibitors and combination therapy to improve efficacy against Mycobacterium tuberculosis.

P. Tonge, R. Slayden, Susan E. Knudson, 2016, Tuberculosis.

Ultrafast proton transfer in the green fluorescent protein: Analysing the instantaneous emission at product state wavelengths

P. Tonge, S. Meech, Minako Kondo, 2012 .

Mechanism of MenE inhibition by acyl-adenylate analogues and discovery of novel antibacterial agents.

Derek S. Tan, P. Tonge, K. Rajashankar, 2015, Biochemistry.

Synthesis and spectroscopic studies of model red fluorescent protein chromophores.

P. Tonge, A. Bell, Xiang He, 2002, Organic letters.

Observation of carbonyl stretch vibrations in acyl-chymotrypsins by using Fourier transform infrared spectroscopy

C. Wharton, P. Tonge, 1985 .

Critical role of reverse transcriptase in the inhibitory mechanism of CNI-H0294 on HIV-1 nuclear translocation.

M. Bukrinsky, M. Rexach, P. Tonge, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Infrared spectroscopy reveals multi-step multi-timescale photoactivation in the photoconvertible protein archetype dronpa

A. Miyawaki, G. M. Greetham, P. Donaldson, 2018, Nature Chemistry.

Ultrafast excited and ground-state dynamics of the green fluorescent protein chromophore in solution

P. Tonge, A. Bell, M. Vengris, 2004 .

Time-Resolved Emission Spectra of Green Fluorescent Protein

P. Matousek, M. Towrie, P. Tonge, 2006 .

Symposium-in-Print: Green Fluorescent Protein and Homologs Time-Resolved Emission Spectra of Green Fluorescent Protein

P. Matousek, M. Towrie, P. Tonge, 2006 .

Elucidation of the protonation states of the catalytic residues in mtKasA: implications for inhibitor design.

P. Tonge, B. Engels, C. Kisker, 2011, Biochemistry.

Noninvasive Determination of 2-[18F]-Fluoroisonicotinic Acid Hydrazide Pharmacokinetics by Positron Emission Tomography in Mycobacterium tuberculosis-Infected Mice

P. Tonge, S. K. Jain, J. Hooker, 2012, Antimicrobial Agents and Chemotherapy.

Evaluating the Impact of the Tyr158 pKa on the Mechanism and Inhibition of InhA, the Enoyl-ACP Reductase from Mycobacterium tuberculosis.

P. Tonge, J. Aramini, F. Daryaee, 2023, Biochemistry.

Discovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhA

A. Korkegian, T. Ioerger, P. Tonge, 2018, Life Science Alliance.

Ground state isomerization of a model green fluorescent protein chromophore

Peter J Tonge, P. Tonge, A. Bell, 2003, FEBS letters.

Inhibitors of Fabl, an Enzyme Drug Target in the Bacterial Fatty Acid Biosynthesis Pathway

P. Tonge, Hao Lu, 2008 .

Ultrafast Photoreactions in the Green Fluorescent Protein Studied Through Time Resolved Vibrational Spectroscopy

P. Tonge, S. Meech, K. Ronayne, 2006 .

Proton relay reaction in green fluorescent protein (GFP): Polarization-resolved ultrafast vibrational spectroscopy of isotopically edited GFP.

P. Tonge, S. Meech, K. Ronayne, 2006, The journal of physical chemistry. B.

Ultrafast Dynamics of the BLUF Mutant dAppA Q63E Revealed by TRIR and Fluorescent Upconversion

M. Towrie, P. Tonge, S. Meech, 2010 .

A Novel Interaction Linking the FAS-II and Phthiocerol Dimycocerosate (PDIM) Biosynthetic Pathways*

P. Tonge, Nicole A. Kruh, B. Ruzsicska, 2008, Journal of Biological Chemistry.

Protein photochromism observed by ultrafast vibrational spectroscopy.

A. Miyawaki, G. M. Greetham, M. Towrie, 2013, The journal of physical chemistry. B.

Photocycle alteration and increased enzymatic activity in genetically modified photoactivable adenylate cyclase OaPAC

P. Tonge, E. Telek, S. Meech, 2023, Journal of Biological Chemistry.

Stereoselective Synthesis, Docking, and Biological Evaluation of Difluoroindanediol-Based MenE Inhibitors as Antibiotics

Derek S. Tan, P. Tonge, C. Evans, 2016, Organic letters.

CoA Adducts of 4-Oxo-4-Phenylbut-2-enoates: Inhibitors of MenB from the M. tuberculosis Menaquinone Biosynthesis Pathway.

Carlos Simmerling, Peter J Tonge, Nina Liu, 2011, ACS medicinal chemistry letters.

Discovery of Novel Bruton's Tyrosine Kinase PROTACs with Enhanced Selectivity and Cellular Efficacy.

Nan Wang, P. Tonge, J. Haley, 2023, Journal of medicinal chemistry.

Neutral ceramidase-active site inhibitor chemotypes and binding modes

Y. Hannun, T. Spicer, P. Tonge, 2023, Bioorganic Chemistry.

Crystal structure and Raman studies of dsFP483, a cyan fluorescent protein from Discosoma striata.

P. Tonge, R. Wachter, Meitian Wang, 2008, Journal of molecular biology.

Rotational isomers of N-(β-phenylpropionyl)alanine ethyl dithioester: a Raman spectroscopic and MO study

P. Tonge, P. Carey, R. Fausto, 1994 .

High Accuracy Prediction of PROTAC Complex Structures.

S. Vajda, G. Poda, D. Kozakov, 2023, Journal of the American Chemical Society.

Probing mechanisms of resistance to the tuberculosis drug isoniazid: Conformational changes caused by inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosis

P. Tonge, B. Ruzsicska, R. Rawat, 2007, Protein science : a publication of the Protein Society.