J. Kraus

发表

Synthesis and antiviral activity of new anti-HIV amprenavir bioisosteres.

L. Rocheblave, F. Bihel, C. De Michelis, 2002, Journal of medicinal chemistry.

N-acyl substituted 7-amino-4-chloroisocoumarin: a peptide degradation model via an imide mechanism.

F. Bihel, J. Kraus, C. Garino, 2004, Bioorganic & medicinal chemistry letters.

Naphthyl and coumarinyl biarylpiperazine derivatives as highly potent human beta-secretase inhibitors. Design, synthesis, and enzymatic BACE-1 and cell assays.

T. Iwatsubo, J. Kraus, B. Maigret, 2006, Journal of medicinal chemistry.

Isosterism and molecular modification in drug design: tetrazole analogue of GABA: effects on enzymes of the gamma-aminobutyrate system.

J. Kraus, J L Kraus, 1983, Pharmacological research communications.

New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage.

O. Pourquié, F. Bihel, J. Kraus, 2001, Nature cell biology.

Synthesis of new 3-alkoxy-7-amino-4-chloro-isocoumarin derivatives as new beta-amyloid peptide production inhibitors and their activities on various classes of protease.

O. Pourquié, F. Bihel, J. Kraus, 2003, Bioorganic & medicinal chemistry.

Anti-human immunodeficiency virus type 1 activity and in vitro toxicity of 2'-deoxy-3'-thiacytidine (BCH-189), a novel heterocyclic nucleoside analog

M. Wainberg, B. Spira, J. Kraus, 1991, Antimicrobial Agents and Chemotherapy.

Polymeric analogues of N-formyl peptides are potent activators of degranulation and superoxide production by human neutrophils.

F. Lederer, J. Kraus, P. Ravel, 1990, Biochemical and biophysical research communications.

Why as a Medicinal Chemist I Am Not Optimistic about the Possibility of Finding, in a Reasonable Timeframe, Small‐Molecule Drugs Capable of Curing the Evolution of Alzheimer’s Disease

J. Kraus, 2012, ChemMedChem.

Quinone methides and their prodrugs: a subtle equilibrium between cancer promotion, prevention, and cure.

R. Kiss, J. Kraus, M. Gelbcke, 2011, Current medicinal chemistry.

Synthesis and biological activity of N-substituted spiro[benzoxazepine-piperidine] Aβ-peptide production inhibitors

T. Iwatsubo, J. Kraus, T. Tomita, 2008 .

N,N-Bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines (HQNBA): peroxisome proliferator-activated receptor (PPAR-γ) agonists with neuroprotective properties.

J. Kraus, P. Maher, S. Madonna, 2010, Bioorganic & medicinal chemistry letters.

Bis-8-hydroxyquinoline and bis-8-hydroxyquinaldine N-substituted amines: A single methyl group structural difference between the two heterocycles, which modulates the antiproliferative effects

S. Spiegl-Kreinecker, C. Pirker, W. Berger, 2010 .

JLK1486, a Bis 8-Hydroxyquinoline-Substituted Benzylamine, Displays Cytostatic Effects in Experimental Gliomas through MyT1 and STAT1 Activation and, to a Lesser Extent, PPARγ Activation.

R. Kiss, J. Kraus, V. Mathieu, 2011, Translational oncology.

Imino-tetrahydro-benzothiazole derivatives as p53 inhibitors: discovery of a highly potent in vivo inhibitor and its action mechanism.

J. Kraus, M. Bähr, N. Pietrancosta, 2006, Journal of medicinal chemistry.

Cyclic tetrameric clusters of chemotactic peptides as superactive activators of lysozyme release from human neutrophils.

J. Kraus, B. Belleau, A. DiPaola, 1984, Biochemical and biophysical research communications.

Novel synthesis of 3,4-dihydro-5-bromo[1,4]oxazin-2-one derivatives, new protease inhibitor scaffold.

F. Bihel, J. Kraus, 2003, Organic & biomolecular chemistry.

Thiazolamide–Ascorbic Acid Conjugate: a γ-Secretase Inhibitor with Enhanced Blood–Brain Barrier Permeation

J. Kraus, N. Pietrancosta, Y. Laras, 2007 .

Blood–brain barrier permeability and transport studies of JLK1486: a new antiglioblastoma drug

J. Kraus, M. Barthélémy-Requin, S. Madonna, 2012, Medicinal Chemistry Research.

Substituted thiazolamide coupled to a redox delivery system: a new gamma-secretase inhibitor with enhanced pharmacokinetic profile.

M. Wolfe, F. Bihel, J. Kraus, 2005, Organic & biomolecular chemistry.

New Non-Peptidic Inhibitors of γ-Secretase Abolish Aβ Production Without Modifying Notch Cleavage

O. Pourquié, Y. Suh, F. Bihel, 2002 .

New Phosphonate Analogues of 3′-Thia-2′,3′-dideoxycytidine(BCH-189) Synthesis and Anti-HIV Evaluation

J. Kraus, 1993 .

Design, Anti-Hiv Activity, Cellular Pharmacology and Conformation of BCH-189 [(±)3TC], A Novel Nucleoside Analogue

M. Wainberg, J. Kraus, M. Hershfield, 1992 .

Synthesis and Anti-HIV Evaluation of New 5-Substituted-2′,3′-Dideoxy-3′-thiauridine Nucleosides

J. Chermann, J. Kraus, M. Camplo, 1996 .

Peptide-Nucleoside Conjugates: Synthesis and Anti-HIV Activities

J. Chermann, J. Kraus, M. Camplo, 1995 .

SYNTHESIS AND ANTI-HIV SCREENING OF SOME HETEROCYCLIC COMPOUNDS

J. Chermann, J. Kraus, R. Verma, 1997 .

Synthesis and Biological Evaluation of a New N4-(N-Formyl Peptide)- 2′,3′-Dideoxy-3′-Thiacytidine as Anti-Hiv Prodrug

F. Lederer, J. Chermann, J. Kraus, 1993 .

Design of β-Secretase Inhibitors by Introduction of a Mandelyl Moiety in DAPT Analogues

J. Kraus, C. Garino, G. Quéléver, 2005 .

Sodium transport by an ionizable and a neutral mobile carrier: effects of membrane structure on the apparent activation energy.

J. Kraus, M. Castaing, G. Vareille, 1993, Biochimica et biophysica acta.

Temperature-dependent effects of cholesterol on sodium transport through lipid membranes by an ionizable mobile carrier.

S. Wehrli, J. Kraus, M. Castaing, 1992, Biochimica et biophysica acta.

Neuroprotective Effects of N‐Alkyl‐1,2,4‐oxadiazolidine‐3,5‐diones and Their Corresponding Synthetic Intermediates N‐Alkylhydroxylamines and N‐1‐Alkyl‐3‐carbonyl‐1‐hydroxyureas against in vitro Cerebral Ischemia

J. Kraus, P. Maher, Alain César Biraboneye, 2010, ChemMedChem.

ER stress in temozolomide-treated glioblastomas interferes with DNA repair and induces apoptosis

J. Kraus, A. Ross, Jessica L. Weatherbee, 2016, Oncotarget.

1,1'-Xylyl bis-1,4,8,11-tetraaza cyclotetradecane: a new potential copper chelator agent for neuroprotection in Alzheimer's disease. Its comparative effects with clioquinol on rat brain copper distribution.

J. Kraus, C. Garino, G. Quéléver, 2006, Bioorganic & medicinal chemistry letters.

Potent HIV protease inhibitors containing a novel (2-phenylsulfanyl-1-hydroxyethyl)amide isostere

L. Rocheblave, G. Priem, J. Kraus, 1999 .

New 3'-azido-3'-deoxythymidin-5'-yl O-(4-hydroxyalkyl or -alkenyl or -alkylepoxide) carbonate prodrugs: synthesis and anti-HIV evaluation.

E. De Clercq, C. Pannecouque, J. Kraus, 2001, Journal of medicinal chemistry.

New 3'-azido-3'-deoxythymidin-5'-yl O-(omega-hydroxyalkyl) carbonate prodrugs: synthesis and anti-HIV evaluation.

E. De Clercq, C. Pannecouque, F. Bihel, 2001, Journal of medicinal chemistry.

Blood–brain barrier permeability and transport studies of JLK1486: a new antiglioblastoma drug

J. Kraus, M. Barthélémy-Requin, J. Nugier, 2012, Medicinal Chemistry Research.

New 2-bromomethyl-8-substituted-benzo[c]chromen-6-ones. Synthesis and biological properties.

F. Bihel, J. Kraus, J. Boucher, 2005, Bioorganic & medicinal chemistry letters.

Synthesis of New 2,5‐Substituted 1,3‐Oxathiolanes. Intermediates in Nucleoside Chemistry.

J. Kraus, G. Attardo, 1992 .

Design and activity of a novel class of nucleoside analogs effective against hiv 1

J. Kraus, B. Belleau, D. Dixit, 1989 .

Design of potential new HIV protease inhibitors: enantioconvergent synthesis of new pyrrolidin-3-ol, and pyrrolidin-3-one peptide conjugates

F. Bihel, J. Courcambeck, J. Kraus, 2001 .

Urea cyclisation reaction studies

J. Kraus, M. Camplo, J. Dessolin, 1997 .

Novel phenyl(thio)ureas bearing (thio)oxothiazoline group as potential BACE-1 inhibitors: synthesis and biological evaluation

J. Kraus, Federico Andreoli, N. Vanthuyne, 2013, Journal of enzyme inhibition and medicinal chemistry.

Artificial intelligence applied to the production of high-added-value dinoflagellates toxins

J. Kraus, 2020, AI & SOCIETY.

The Bioorganic Chemistry of N-Allyl and N-Propargyl Substituents in Drug Interactions with Flavin-linked Oxidases

J. Kraus, B. Belleau, 1975 .

New 2-bromomethyl-8-substituted-benzo[c]chromen-6-ones. Synthesis and biological properties.

F. Bihel, J. Kraus, J. Boucher, 2005, Bioorganic & medicinal chemistry letters.

Synthesis and anti-HIV activities of symmetrical N1,N3-dibenzyl-2-hydroxy-propane derivatives.

L. Rocheblave, J. Chermann, J. Kraus, 1998, Bioorganic & medicinal chemistry letters.

Synthesis of new 7-membered α-phenylthio cyclic oxamides: HIV inhibitors

G. Priem, J. Kraus, G. Quéléver, 1998 .

BACE-1 inhibitory activities of new substituted phenyl-piperazine coupled to various heterocycles: chromene, coumarin and quinoline.

J. Kraus, C. Garino, G. Quéléver, 2006, Bioorganic & medicinal chemistry letters.

Synthesis of New 2,5-Substituted 1,3-Oxathiolanes. Intermediates in Nucleoside Chemistry

J. Kraus, G. Attardo, 1991 .

Novel cyclized Pifithrin-α p53 inactivators: synthesis and biological studies

J. Kraus, C. Garino, G. Quéléver, 2005 .

Use of proline bioisosteres in potential HIV protease inhibitors: phenylalanine-2-thiophenoxy-3-pyrrolidinone: synthesis and anti-HIV evaluation.

J. Courcambeck, J. Chermann, J. Kraus, 2000, Bioorganic & medicinal chemistry letters.

Synthesis and anti-HIV evaluation of new 2′,3′- dideoxy-3′-thiacytidine prodrugs

J. Chermann, J. Kraus, M. Camplo, 2000, Nucleosides, nucleotides & nucleic acids.

Synthesis and anti-HIV activity of alpha-thiophenoxy-hydroxyethylamide derivatives.

L. Rocheblave, G. Priem, J. Chermann, 1999, European journal of medicinal chemistry.

Reactivity studies of 3-alkoxy-7-amino-4-chloroisocoumarins (beta-amyloid peptide inhibitors) versus different classes of amines.

F. Bihel, J. Kraus, R. Faure, 2003, Organic & biomolecular chemistry.

Efficient synthesis of 5,8-disubstituted-1,4-dihydrobenzoxathiin-3-oxides and their isomeric structures, 4,7-disubstituted-1,3-dihydrobenzo[b] thiophene-2,2-dioxides

J. Kraus, G. Attardo, B. Belleau, 1994 .

Short and unexpectedly potent 3-pyrrolidinone type inhibitors of HIV-1 replication

J. Chermann, J. Kraus, M. Camplo, 1998 .

New antiviral nucleoside prodrugs await application.

J. Kraus, C. Garino, F. Souard, 2003, Current medicinal chemistry.

Approaches toward the synthesis of 2,5-disubstituted-1,3-thiazolidines

J. Kraus, P. Barthélémy, M. Camplo, 1994 .

Discovery of a new family of bis-8-hydroxyquinoline substituted benzylamines with pro-apoptotic activity in cancer cells: synthesis, structure-activity relationship, and action mechanism studies.

J. Kraus, U. Testa, Diane Allegro, 2009, European journal of medicinal chemistry.

Therapeutic Links between Alzheimer’s Disease and Brain Cancer: Drug Discovery Consequences

J. Kraus, 2013, ChemMedChem.

Temperature-jump method for studying the fast transport of Na+ by (221) C10-cryptand across lipid membranes.

J. Kraus, J. Ricard, M. Castaing, 1991, Biophysical chemistry.

Permeability of cryptands through dihexadecyl phosphate bilayer membranes.

J. Kraus, M. Castaing, C. Ponge, 1991, Biophysical chemistry.

Simple coupling reaction between amino acids and weakly nucleophilic heteroaromatic amines.

J. Kraus, C. Garino, G. Quéléver, 2004, Journal of combinatorial chemistry.

Synthesis and anti-HIV properties of new hydroxyquinoline-polyamine conjugates on cells infected by HIV-1 LAV and HIV-1 BaL viral strains.

J. Kraus, N. Pietrancosta, Y. Laras, 2006, Bioorganic & medicinal chemistry letters.

Inhibition of the cytochrome P-450 multifunctional oxidase by N-propargyl analogs of SKF-525A and acetylmethadol

J. Kraus, J. Yaouanc, 2010, European Journal of Drug Metabolism and Pharmacokinetics.

Syntheses of new unsymmetrical bispolyazamacrocycles

J. Kraus, G. Quéléver, M. Camplo, 1998 .

Synthesis and biological activities of new N-formylated methionyl peptides containing an α-substituted glycine residue

J. Kraus, G. Attardo, 1992 .

Selective inhibition of the duck hepatitis B virus by a new class of tetraazamacrocycles

F. Zoulim, J. Kraus, C. Borel, 1997, Antimicrobial agents and chemotherapy.

Reactivity of organo lithium reagents on dimethyl squarate : a 1,2-addition process leading to new 2-hydroxy-3,4 dimethoxy 3-cyclobutenone

J. Kraus, 1985 .

Synthesis and anti-human immunodeficiency virus type 1 activities of new peptido-nucleoside analogues

J. Chermann, J. Kraus, P. Barthélémy, 1995 .

Modelisation, synthesis and antiviral evaluation of new 2,3-disubstituted thiazolidinone nucleoside analogues

F. Zoulim, J. Chermann, J. Kraus, 1996 .

Synthesis of New Thiazolidinone Nucleoside Analogues.

J. Kraus, M. Camplo, N. Mourier, 1995 .

Synthesis of New Thiazolidinone Nucleoside Analogues

J. Kraus, M. Camplo, N. Mourier, 1995 .

Inhibition of human immunodeficiency virus type 1 replication by phosphonoformate- and phosphonoacetate-2',3'-dideoxy-3'-thiacytidine conjugates.

J. Chermann, J. Kraus, M. Camplo, 1994, Journal of medicinal chemistry.

Design and evaluation of hepatitis B virus inhibitors.

F. Zoulim, J. Kraus, O. Hantz, 2000, Current pharmaceutical design.

HIV Reverse Transcriptase (RT) and HIV Protease Inhibitors

J. Chermann, J. Kraus, M. Camplo, 1997 .

Modelization, Synthesis and Antiviral Evaluation of New 2,3‐ Disubstituted Thiazolidinone Nucleoside Analogues.

F. Zoulim, J. Chermann, J. Kraus, 1996 .

Synthesis and antiviral activity of N-4′-dihydropyridinyl and dihydroquinolinylcarbonyl-2-hydroxymethyl-5-[cytosin-1′-yl]-1,3-oxathiolane derivatives against human immunodeficiency virus and duck hepatitis B virus

J. Chermann, J. Kraus, C. Borel, 1996 .

Prospects for the resistance to HIV protease inhibitors: current drug design approaches and perspectives.

Jean-Louis Kraus, J. Kraus, C. Garino, 2005, Current pharmaceutical design.

Synthesis and comparative anti-HIV activities of new acetylated 2′,3′-dideoxy-3′-thiacytidine analogues

J. Chermann, J. Kraus, M. Camplo, 1994 .

Erratum to “Are 5′-O-Carbamate-2′,3′-dideoxythiacytidine new anti-HIV and anti-HBV nucleoside drugs or prodrugs?”[Bioorg. Med. Chem. Lett. 13 (2003) 2459] ☆

C. Pannecouque, J. Kraus, D. Dormont, 2003 .

Are 5'-O-carbamate-2',3'-dideoxythiacytidine new anti-HIV and anti-HBV nucleoside drugs or prodrugs?

E. De Clercq, C. Pannecouque, J. Kraus, 2003, Bioorganic & medicinal chemistry letters.

New protease inhibitors prevent γ-secretase-mediated production of Aβ40/42 without affecting Notch cleavage

Olivier Pourquié, Jean-Louis Kraus, O. Pourquié, 2001, Nature Cell Biology.

Passive permeability of dihexadecyl phosphate vesicles altered by aliphatic alcohols and ω-diols

J. Kraus, M. Camplo, M. Castaing, 1991 .

Synthèse de N‐2 alkyl (aryl) dioxo‐3,5 oxadiazolidine‐1,2,4

J. Kraus, J. Yaouanc, P. Dugenet, 1982 .

Alternative responses of primary tumor cells and glioblastoma cell lines to N,N-bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines: cell death versus P53-independent senescence.

J. Kraus, F. Conti, A. Tchoghandjian, 2010, International journal of oncology.

Artificial intelligence applied to the production of high-added-value dinoflagellates toxins

Jean-louis Kraus, J. Kraus, 2020, AI & SOCIETY.

Synthesis and Anti-Proliferative Activity of Novel Quinolin-8-ol Derivatives

J. Kraus, T. Cresteil, Geneviève Aubert, 2011 .

Is Alzheimer's Disease an Irreversible Loss of Memory Function with No Hope of Return?

J. Kraus, 2014 .

New anti-HIV derivatives: synthesis and antiviral evaluation.

L. Rocheblave, C. De Michelis, G. Priem, 2000, Bioorganic & medicinal chemistry.

Synthesis and biological activity of phosphonate analogues and geometric isomers of the highly potent phosphoantigen (E)-1-hydroxy-2-methylbut-2-enyl 4-diphosphate.

Christian Belmant, Jean Dessolin, Jean-Louis Kraus, 2008, Journal of medicinal chemistry.

JLK1486, a N,N‐[(8‐hydroxyquinoline)methyl]‐substituted benzylamine analogue, inhibits melanoma proliferation and induces autophagy

J. Kraus, M. Venter, T. Koekemoer, 2014, Cell proliferation.

Structure-activity relationships and mechanism of action of antitumor bis 8-hydroxyquinoline substituted benzylamines.

R. Kiss, J. Kraus, T. Cresteil, 2010, European journal of medicinal chemistry.

Simple di- and trivanillates exhibit cytostatic properties toward cancer cells resistant to pro-apoptotic stimuli.

R. Kiss, J. Kraus, A. Kornienko, 2010, Bioorganic & medicinal chemistry.

From 'molecules of life' to new therapeutic approaches, an evolution marked by the advent of artificial intelligence: the cases of chronic pain and neuropathic disorders.

J. Kraus, 2021, Drug discovery today.

And if the discovery of new drugs for the treatment of brain diseases depends on Asian countries?

J. Kraus, 2014, Journal of market access & health policy.

Can artificial intelligency revolutionize drug discovery?

Jean-Louis Kraus, J. Kraus, 2019, AI & SOCIETY.

Novel cyclized Pifithrin-alpha p53 inactivators: synthesis and biological studies.

J. Kraus, C. Garino, G. Quéléver, 2005, Bioorganic & medicinal chemistry letters.

Isosterism and molecular modification in drug design: new n-dipropylacetate analogs as inhibitors of succinic semi aldehyde dehydrogenase.

J. Kraus, 1983, Pharmacological research communications.

New bicyclam-AZT conjugates: design, synthesis, anti-HIV evaluation, and their interaction with CXCR-4 coreceptor.

J. Chermann, J. Kraus, P. Vlieghe, 1999, Journal of medicinal chemistry.

Characterization of Novel Neuroprotective Lipid Analogues for the Treatment of Stroke

J. Kraus, P. Maher, Alain César Biraboneye, 2012 .

Synthesis of new covalently bound kappa-carrageenan-AZT conjugates with improved anti-HIV activities.

Myriam Witvrouw, Christophe Pannecouque, Jean-Louis Kraus, 2002, Journal of medicinal chemistry.

Discovery of new small molecules that influence neuroblast cell migration from the subventricular zone.

J. Kraus, Y. Laras, J. Norreel, 2008, Bioorganic & Medicinal Chemistry Letters.

Tri-N-Boc-tetraazamacrocycle-nucleoside conjugates: synthesis and anti-HIV activities.

J. Chermann, J. Kraus, G. Quéléver, 1998, Nucleosides & nucleotides.

Tri‐N‐Boc‐tetraazamacrocycle—Nucleoside Conjugates: Synthesis and Anti‐HIV Activities.

J. Chermann, J. Kraus, G. Quéléver, 2010 .

Potential neuroprotective drugs in cerebral ischemia: new saturated and polyunsaturated lipids coupled to hydrophilic moieties: synthesis and biological activity.

J. Kraus, P. Maher, S. Krantic, 2009, Journal of medicinal chemistry.

Are p53 inhibitors potentially useful therapeutics?

J. Kraus, C. Garino, G. Quéléver, 2005 .

A new Met inhibitory-scaffold identified by a focused forward chemical biological screen.

Bernard Maigret, Vincent Leroux, Jean-Louis Kraus, 2008, Biochemical and biophysical research communications.

New N4-substituted piperazine naphthamide derivatives as BACE-1 inhibitors

J. Kraus, C. Garino, Y. Laras, 2009 .

Effect of new biologically active polypeptides on dihexadecyl phosphate vesicles.

J. Kraus, P. Ménassa, 1987, Pharmacological research communications.

Syntheses of new modified Phe-Pro peptides. Use of proline replacements in potential HIV inhibitors.

J. Chermann, J. Kraus, G. Quéléver, 1998, Bioorganic & medicinal chemistry letters.

Studies on the structural requirements for synthetic formyl peptide chemoattractants.

J. Kraus, 1986, Pharmacological research communications.

Synthesis of New Substituted 4,5-Dihydro-3H-spiro[1,5]-benzoxazepine-2,4′-piperidine and Biological Properties

J. Kraus, C. Garino, N. Pietrancosta, 2006 .

Cholesterol and Sitosterol, Two Members of the Steroid Family That Differ in Structure by a Single Ethyl Group Yet Maintain the Right Balance between Plant and Animal Kingdoms

J. Kraus, 2020, Russian Journal of Bioorganic Chemistry.