K. Omori

发表

Striatum- and testis-specific phosphodiesterase PDE10A isolation and characterization of a rat PDE10A.

K. Fujishige, J. Kotera, K. Omori, 1999, European journal of biochemistry.

Transcriptional activation of phosphodiesterase 7B1 by dopamine D1 receptor stimulation through the cyclic AMP/cyclic AMP‐dependent protein kinase/cyclic AMP‐response element binding protein pathway in primary striatal neurons

J. Kotera, K. Omori, Takashi Sasaki, 2004, Journal of neurochemistry.

Novel, potent, and selective phosphodiesterase 5 inhibitors: synthesis and biological activities of a series of 4-aryl-1-isoquinolinone derivatives.

J. Kotera, K. Omori, T. Ukita, 2001, Journal of medicinal chemistry.

Genomic organization of the human phosphodiesterase PDE11A gene. Evolutionary relatedness with other PDEs containing GAF domains.

K. Omori, K. Yuasa, K. Okumura, 2001, European journal of biochemistry.

The ABC-exporter genes involved in the lipase secretion are clustered with the genes for lipase, alkaline protease, and serine protease homologues in Pseudomonas fluorescens no. 33.

K. Omori, K. Shimazaki, H. Kumura, 1999, Biochimica et biophysica acta.

Identification of a conserved residue responsible for the autoinhibition of cGMP‐dependent protein kinase Iα and β

K. Omori, N. Yanaka, K. Yuasa, 2000 .

Identification of a conserved residue responsible for the autoinhibition of cGMP-dependent protein kinase Ialpha and beta.

K. Omori, N. Yanaka, K. Yuasa, 2000, FEBS letters.

Two species of RNA polymerase II released from rat liver chromatin

K. Omori, K. Omori, Y. Okai, 1979, FEBS letters.

Isolation and characterization of the 5'-flanking regulatory region of the human natriuretic peptide receptor C gene.

J. Kotera, K. Omori, N. Yanaka, 1998, Endocrinology.

Structure of the 5'-flanking regulatory region of the mouse gene encoding the clearance receptor for atrial natriuretic peptide.

J. Kotera, K. Omori, N. Yanaka, 1996, European journal of biochemistry.

Localization of clearance receptor in rat lung and trachea: association with chondrogenic differentiation.

K. Fujishige, K. Omori, N. Yanaka, 1998, The American journal of physiology.

The apolipoprotein AICIII-AIV gene cluster: sequence of the ApoCIII-ApoAIV intergenic region.

K. Omori, L. Vergnes, M. Zakin, 1995, Gene.

Trichostatin A and herboxidiene up-regulate the gene expression of low density lipoprotein receptor.

J. Kotera, K. Omori, S. Komatsubara, 1997, The Journal of antibiotics.

Phosphatidylinositol 5-phosphate 4-kinase

F. Tamanoi, K. Jacobson, Mark A Sussman, 2012 .

TMC-49A, a novel transcriptional up-regulator of low density lipoprotein receptor, produced by Streptomyces sp. AS1345.

Y. Asai, K. Omori, N. Yanaka, 1998, The Journal of antibiotics.

cGMP-Phosphodiesterase Activity Is Up-regulated in Response to Pressure Overload of Rat Ventricles

K. Omori, N. Yanaka, E. Kawai, 2003, Bioscience, biotechnology, and biochemistry.

Potential role of phosphodiesterase 7 in human T cell function: comparative effects of two phosphodiesterase inhibitors

T. Sasaki, J. Kotera, K. Omori, 2002, Clinical and experimental immunology.

Identification of rat cyclic nucleotide phosphodiesterase 11A (PDE11A): comparison of rat and human PDE11A splicing variants.

K. Omori, K. Yuasa, T. Ohgaru, 2001, European journal of biochemistry.

Expression, structure and chromosomal localization of the human cGMP-binding cGMP-specific phosphodiesterase PDE5A gene.

K. Fujishige, J. Kotera, K. Omori, 1998, European journal of biochemistry.

Enzymological and pharmacological profile of T-0156, a potent and selective phosphodiesterase type 5 inhibitor.

H. Inoue, K. Fujishige, J. Kotera, 2002, European journal of pharmacology.

Functional Characterization of the HasAPF Hemophore and Its Truncated and Chimeric Variants: Determination of a Region Involved in Binding to the Hemophore Receptor

K. Omori, S. Létoffé, C. Wandersman, 2000, Journal of bacteriology.

Lipase secretion by bacterial hybrid ATP-binding cassette exporters: molecular recognition of the LipBCD, PrtDEF, and HasDEF exporters

K. Omori, C. Wandersman, H. Akatsuka, 1997, Journal of bacteriology.

Role of repetitive nine-residue sequence motifs in secretion, enzymatic activity, and protein conformation of a family I.3 lipase.

K. Omori, S. Kanaya, M. Haruki, 2002, Journal of bioscience and bioengineering.

Isolation and analysis of lipase-overproducing mutants of Serratia marcescens.

N. Sakurai, K. Omori, S. Komatsubara, 2001, Journal of bioscience and bioengineering.

Overproduction of the Extracellular Lipase Is Closely Related to That of Metalloprotease in Serratia marcescens

K. Omori, S. Komatsubara, H. Akatsuka, 1996 .

Alteration of cGMP metabolism during chondrogenic differentiation of chondroprogenitor-like EC cells, ATDC5.

K. Fujishige, J. Kotera, K. Omori, 1999, Biochimica et biophysica acta.

Selectivity of avanafil, a PDE5 inhibitor for the treatment of erectile dysfunction: implications for clinical safety and improved tolerability.

J. Kotera, K. Omori, A. Burnett, 2012, The journal of sexual medicine.

1,25-Dihydroxyvitamin D3upregulates natriuretic peptide receptor-C expression in mouse osteoblasts.

K. Omori, N. Yanaka, H. Akatsuka, 1998, American journal of physiology. Endocrinology and metabolism.

Localization of clearance receptor in rat lung and trachea: association with chondrogenic differentiation.

K. Fujishige, K. Omori, N. Yanaka, 1998, American journal of physiology. Lung cellular and molecular physiology.

1,25-Dihydroxyvitamin D3 upregulates natriuretic peptide receptor-C expression in mouse osteoblasts.

K. Omori, N. Yanaka, H. Akatsuka, 1998, The American journal of physiology.

Protein kinase C activation down‐regulates natriuretic peptide receptor C expression via transcriptional and post‐translational pathways

K. Omori, N. Yanaka, H. Akatsuka, 1997, FEBS letters.

The Discovery of Stendra™(Avanafil) for the Treatment of Erectile Dysfunction

K. Omori, K. Kikkawa, Koichiro Yamada, 2015 .

Serratia marcescens S‐layer protein is secreted extracellularly via an ATP‐binding cassette exporter, the Lip system

K. Omori, H. Akatsuka, A. Idei, 1998, Molecular microbiology.

The three genes lipB, lipC, and lipD involved in the extracellular secretion of the Serratia marcescens lipase which lacks an N-terminal signal peptide

K. Omori, H. Akatsuka, T. Shibatani, 1995, Journal of bacteriology.

Isolation and Characterization of Two Novel Phosphodiesterase PDE11A Variants Showing Unique Structure and Tissue-specific Expression*

K. Fujishige, J. Kotera, K. Omori, 2000, The Journal of Biological Chemistry.

Immunohistochemical Localization of cGMP-binding cGMP-specific Phosphodiesterase (PDE5) in Rat Tissues

K. Fujishige, J. Kotera, K. Omori, 2000, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

1,7- and 2,7-naphthyridine derivatives as potent and highly specific PDE5 inhibitors.

K. Fujishige, J. Kotera, K. Omori, 2003, Bioorganic & medicinal chemistry letters.

Phosphodiesterase-9A: A cGMP-Specific Enzyme

J. Kotera, K. Omori, Takashi, 2010 .

Avanafil, a potent and highly selective phosphodiesterase-5 inhibitor for erectile dysfunction.

H. Inoue, K. Fujishige, J. Kotera, 2012, The Journal of urology.

Overview of PDEs and Their Regulation

J. Kotera, K. Omori, 2007, Circulation research.

Cloning and Characterization of a Novel Human Phosphodiesterase That Hydrolyzes Both cAMP and cGMP (PDE10A)*

K. Fujishige, J. Kotera, K. Omori, 1999, The Journal of Biological Chemistry.

The discovery of avanafil for the treatment of erectile dysfunction: a novel pyrimidine-5-carboxamide derivative as a potent and highly selective phosphodiesterase 5 inhibitor.

K. Fujishige, J. Kotera, K. Omori, 2014, Bioorganic & medicinal chemistry letters.

Active lactonizing lipase (LipL) efficiently overproduced by Pseudomonas strains as heterologous expression hosts.

K. Omori, T. Nihira, F. Ihara, 2005, Journal of bioscience and bioengineering.

Human Ca2+/calmodulin-dependent phosphodiesterase PDE1A: novel splice variants, their specific expression, genomic organization, and chromosomal localization.

K. Omori, N. Yanaka, K. Okumura, 2001, Biochimica et biophysica acta.

The influence of single or fractionated doses of 5-fluoro-2'-deoxycytidine teratogenicity in mice.

K. Omori, H. Sasaki, 1973, Teratology.

Nucleotide sequence of a region in 23-S RNA adjacent to peptidyl transferase catalytic center of Escherichia coli ribosomes.

K. Omori, T. Hatayama, M. Yukioka, 1977, European journal of biochemistry.

Purification and properties of a major casein component of rat milk.

R. Sasaki, K. Omori, M. Maki, 1981, Biochimica et biophysica acta.

The lipA gene of Serratia marcescens which encodes an extracellular lipase having no N-terminal signal peptide

K. Omori, T. Tosa, S. Komatsubara, 1994, Journal of bacteriology.

A Novel Interaction of cGMP-dependent Protein Kinase I with Troponin T*

K. Omori, N. Yanaka, K. Yuasa, 1999, The Journal of Biological Chemistry.

Identification of human PDE7B, a cAMP-specific phosphodiesterase.

T. Sasaki, J. Kotera, K. Omori, 2000, Biochemical and biophysical research communications.

The apolipoprotein A-I/C-III/A-IV gene cluster: ApoC-III and ApoA-IV expression is regulated by two common enhancers.

K. Omori, L. Vergnes, M. Zakin, 1997, Biochimica et biophysica acta.

PCAF Lysine Acetyltransferase

F. Tamanoi, K. Jacobson, Mark A Sussman, 2008 .

Involvement of natriuretic peptide system in C2C12 myocytes

K. Omori, T. Shimomura, K. Ishikawa, 2018, Molecular and Cellular Biochemistry.

Genomic origin and transcriptional regulation of two variants of cGMP-binding cGMP-specific phosphodiesterases.

K. Fujishige, J. Kotera, K. Omori, 1999, European journal of biochemistry.

Expression of rat cGMP-binding cGMP-specific phosphodiesterase mRNA in Purkinje cell layers during postnatal neuronal development.

T. Ishizuka, K. Fujishige, J. Kotera, 1997, European journal of biochemistry.

mRNA expression patterns of the cGMP‐hydrolyzing phosphodiesterases types 2, 5, and 9 during development of the rat brain

M. F. Goy, J. Kotera, K. Omori, 2003, The Journal of comparative neurology.

PfPDE 1 , a novel cGMP-specific phosphodiesterase from the human malaria parasite Plasmodium falciparum

J. Kotera, K. Omori, M. Yamanouchi, 2005 .

Serratia ATP-binding Cassette Protein Exporter, Lip, Recognizes a Protein Region Upstream of the C Terminus for Specific Secretion*

K. Omori, H. Akatsuka, A. Idei, 2001, The Journal of Biological Chemistry.

Gram-negative bacterial ATP-binding cassette protein exporter family and diverse secretory proteins.

K. Omori, A. Idei, 2003, Journal of bioscience and bioengineering.

Cloning and Characterization of thePseudomonas fluorescens ATP-Binding Cassette Exporter, HasDEF, for the Heme Acquisition Protein HasA

K. Omori, H. Akatsuka, A. Idei, 1999, Journal of bacteriology.

Role of serine 352 in the allosteric response of Serratia marcescens aspartokinase I-homoserine dehydrogenase I analyzed by using site-directed mutagenesis

K. Omori, S. Komatsubara, 1993, Journal of bacteriology.

Nucleotide sequence of the Serratia marcescens threonine operon and analysis of the threonine operon mutations which alter feedback inhibition of both aspartokinase I and homoserine dehydrogenase I

K. Omori, Y. Imai, S. Komatsubara, 1993, Journal of bacteriology.

Analysis of the Serratia marcescens proBA operon and feedback control of proline biosynthesis.

K. Omori, Y. Imai, S. Komatsubara, 1991, Journal of general microbiology.

Comparison of enzymatic characterization and gene organization of cyclic nucleotide phosphodiesterase 8 family in humans.

N. Sakurai, J. Kotera, K. Omori, 2003, Cellular signalling.

Subcellular Localization of Cyclic Nucleotide Phosphodiesterase Type 10A Variants, and Alteration of the Localization by cAMP-dependent Protein Kinase-dependent Phosphorylation*

K. Fujishige, J. Kotera, K. Omori, 2004, Journal of Biological Chemistry.

Binding and Phosphorylation of a Novel Male Germ Cell-specific cGMP-dependent Protein Kinase-anchoring Protein by cGMP-dependent Protein Kinase Iα*

K. Omori, N. Yanaka, K. Yuasa, 2000, The Journal of Biological Chemistry.

Involvement of natriuretic peptide system in C2C12 myocytes

K. Omori, T. Shimomura, K. Ishikawa, 2018, Molecular and Cellular Biochemistry.

Girdin is phosphorylated on tyrosine 1798 when associated with structures required for migration.

N. Asai, Masahide Takahashi, A. Enomoto, 2015, Biochemical and biophysical research communications.

Novel alternative splice variants of rat phosphodiesterase 7B showing unique tissue-specific expression and phosphorylation.

J. Kotera, K. Omori, Takashi Sasaki, 2002, The Biochemical journal.

Partial characterization of RNA polymerase II complex released by micrococcal nuclease digestion of rat liver nuclei.

K. Omori, T. Hatayama, A. Inoue, 1981, Biochimica et biophysica acta.

Promotion of non-rapid eye movement sleep in mice after oral administration of ornithine

K. Omori, Y. Urade, N. Matsumoto, 2012 .

Targeted Disruption of Na+/Ca2+ Exchanger Gene Leads to Cardiomyocyte Apoptosis and Defects in Heartbeat*

S. Kudoh, O. Kohmoto, Y. Yazaki, 2000, The Journal of Biological Chemistry.

Crystal Structure of the GAF-B Domain from Human Phosphodiesterase 10A Complexed with Its Ligand, cAMP*

S. Yokoyama, J. Kotera, K. Omori, 2008, Journal of Biological Chemistry.

Novel Alternative Splice Variants of cGMP-binding cGMP-specific Phosphodiesterase*

K. Fujishige, J. Kotera, K. Omori, 1998, The Journal of Biological Chemistry.

Molecular comparison of rat cyclic nucleotide phosphodiesterase 8 family: unique expression of PDE8B in rat brain.

J. Kotera, K. Omori, Takashi Sasaki, 2003, Gene.

Novel Membrane Protein Containing Glycerophosphodiester Phosphodiesterase Motif Is Transiently Expressed during Osteoblast Differentiation*

N. Sakurai, K. Omori, N. Yanaka, 2003, Journal of Biological Chemistry.

Morphology-Based Analysis of Myoblasts for Prediction of Myotube Formation

Ryuji Kato, Kei Kanie, Kei Yoshida, 2018, SLAS discovery : advancing life sciences R & D.

l-Serine Production by a Mutant of Sarcina albida Defective in l-Serine Degradation

K. Omori, I. Chibata, T. Kakimoto, 1983, Applied and environmental microbiology.

N-Acyl-l-Homoserine Lactone-Mediated Regulation of the Lip Secretion System inSerratia liquefaciens MG1

K. Omori, L. Eberl, T. S. Hansen, 2001, Journal of bacteriology.

Characterization and effects of methyl-2- (4-aminophenyl)-1, 2-dihydro-1-oxo-7- (2-pyridinylmethoxy)-4-(3,4, 5-trimethoxyphenyl)-3-isoquinoline carboxylate sulfate (T-1032), a novel potent inhibitor of cGMP-binding cGMP-specific phosphodiesterase (PDE5).

K. Fujishige, J. Kotera, K. Omori, 2000, Biochemical pharmacology.

Characterization and phosphorylation of PDE10A2, a novel alternative splice variant of human phosphodiesterase that hydrolyzes cAMP and cGMP.

K. Fujishige, J. Kotera, K. Omori, 1999, Biochemical and biophysical research communications.

PfPDE1, a novel cGMP-specific phosphodiesterase from the human malaria parasite Plasmodium falciparum.

J. Kotera, K. Omori, M. Yamanouchi, 2005, The Biochemical journal.

Divergence of a flagellin protein in Serratia marcescens.

K. Omori, H. Akatsuka, T. Shibatani, 1995, Gene.

The human phosphodiesterase PDE10A gene

K. Fujishige, J. Kotera, K. Omori, 2000 .

Isolation and Characterization of Na+/Ca2+ Exchanger Gene and Splicing Isoforrns in Mice

I. Komuro, K. Omori, M. Kuro-o, 2000 .

PTPe (RPTPe and Cyt-PTPe)

F. Tamanoi, K. Jacobson, Mark A Sussman, 2012 .

Analysis of the mutant proBA operon from a proline-producing strain of Serratia marcescens.

K. Omori, Y. Imai, S. Komatsubara, 1992, Journal of general microbiology.

8-(3-chloro-4-methoxybenzyl)-8H-pyrido[2,3-d]pyrimidin-7-one derivatives as potent and selective phosphodiesterase 5 inhibitors.

K. Fujishige, J. Kotera, K. Omori, 2015, Bioorganic & medicinal chemistry letters.

Design and synthesis of novel 5-(3,4,5-trimethoxybenzoyl)-4-aminopyrimidine derivatives as potent and selective phosphodiesterase 5 inhibitors: scaffold hopping using a pseudo-ring by intramolecular hydrogen bond formation.

K. Fujishige, J. Kotera, K. Omori, 2014, Bioorganic & medicinal chemistry letters.

Enzymatic resolution of diltiazem intermediate by Serratia marcescens lipase : molecular mechanism of lipase secretion and its industrial application

K. Omori, H. Akatsuka, H. Matsumae, 2000 .

The Serratia marcescens bioH gene encodes an esterase.

N. Sakurai, K. Omori, H. Akatsuka, 2003, Gene.

Purification and characterization of four components of rat caseins.

R. Sasaki, K. Omori, M. Hirose, 1981, Biochimica et biophysica acta.

Crystal Structure of the GAF-B Domain from Human Phosphodiesterase 10A Complexed with Its Ligand, cAMP*

S. Yokoyama, J. Kotera, K. Omori, 2008, Journal of Biological Chemistry.

Utilization of ATP-binding cassette exporter for hyperproduction of an exoprotein: construction of lipase-hyperproducing recombinant strains of Serratia marcescens

K. Omori, H. Akatsuka, A. Idei, 2002, Applied Microbiology and Biotechnology.

Discovery of 2-[(E)-2-(7-Fluoro-3-methylquinoxalin-2-yl)vinyl]-6-pyrrolidin-1-yl-N-(tetrahydro-2H-pyran-4-yl)pyrimidin-4-amine Hydrochloride as a Highly Selective PDE10A Inhibitor.

J. Kotera, K. Omori, Takashi Sasaki, 2018, Chemical and pharmaceutical bulletin.

Dynamics of Estrio1-16-Glucosiduronate (E 3 -16-G) in Early Pregnancy-its Prognostic Value in Complicated Pregnancy

K. Omori, 1982 .