S. Okumura

发表

Motor Dysfunction in Type 5 Adenylyl Cyclase-null Mice*

S. Vatner, T. Iwamoto, S. Okumura, 2003, The Journal of Biological Chemistry.

Post-stress perfusion abnormalities detected on myocardial perfusion single-photon emission computed tomography predict long-term mortality after elective abdominal aortic aneurysm repair.

S. Okumura, M. Hayashi, K. Komori, 2013, Circulation journal : official journal of the Japanese Circulation Society.

Oscillation of cAMP and Ca2+ in cardiac myocytes: a systems biology approach

H. Kitano, Samik Ghosh, S. Okumura, 2015, The Journal of Physiological Sciences.

Simultaneous hyperthermia-chemotherapy with controlled drug delivery using single-drug nanoparticles

I. Tohnai, K. Mitsudo, S. Okumura, 2016, Scientific Reports.

Drug therapy aimed at adenylyl cyclase to regulate cyclic nucleotide signaling.

S. Okumura, K. Iwatsubo, Y. Ishikawa, 2006, Endocrine, metabolic & immune disorders drug targets.

Inhibition of phosphodiesterase type 3 dilates the rat ductus arteriosus without inducing intimal thickening.

S. Okumura, Y. Ishikawa, M. Masuda, 2012, Circulation journal : official journal of the Japanese Circulation Society.

Relationship between bite size per mouthful and dental arch size in healthy subjects

S. Okumura, Y. Saeki, K. Shiozawa, 2018, The Journal of Physiological Sciences.

Caveolin regulates microtubule polymerization in the vascular smooth muscle cells.

S. Okumura, J. Kawabe, Y. Ishikawa, 2006, Biochemical and biophysical research communications.

Epac1 Deficiency Attenuated Vascular Smooth Muscle Cell Migration and Neointimal Formation

S. Okumura, Y. Ishikawa, T. Tamura, 2015, Arteriosclerosis, thrombosis, and vascular biology.

A Second Attack of Anisakis: Intestinal Anisakiasis Following Gastric Anisakiasis

S. Okumura, M. Ogawa, Naoto Mizumura, 2018, ACG case reports journal.

Impact of physical function on indeterminable anaerobic threshold in patients with heart failure

E. Saitoh, Y. Otaka, Y. Aoyagi, 2020, Fujita medical journal.

Clinical Characteristics and Predictors of Super‐Response to Cardiac Resynchronization Therapy: A Combination of Predictive Factors

S. Okumura, M. Hirai, T. Murohara, 2014, Pacing and clinical electrophysiology : PACE.

New aspects for the treatment of cardiac diseases based on the diversity of functional controls on cardiac muscles: effects of targeted disruption of the type 5 adenylyl cyclase gene.

S. Okumura, Y. Ishikawa, Sayaka Suzuki, 2009, Journal of pharmacological sciences.

Effect of ascorbic acid on reactive oxygen species production in chemotherapy and hyperthermia in prostate cancer cells

S. Okumura, Y. Ishikawa, Tomoyuki Saito, 2012, The Journal of Physiological Sciences.

Impact of albuminuria on the incidence of periprocedural myocardial injury in patients undergoing elective coronary stent implantation.

S. Okumura, T. Murohara, H. Ishii, 2014, The American journal of cardiology.

Long-term Survival Following Repeated Abdominal Para-aortic Lymph Node Dissection after Postcurative Gastrectom

S. Okumura, M. Kameyama, M. Ogawa, 2016 .

Impact of diabetic retinopathy on late cardiac events after percutaneous coronary intervention.

S. Okumura, T. Murohara, H. Ishii, 2014, Journal of cardiology.

Accelerated decline in renal function after acute myocardial infarction in patients with high low-density lipoprotein-cholesterol to high-density lipoprotein-cholesterol ratio

S. Okumura, M. Hayashi, T. Murohara, 2012, Heart and Vessels.

Influence of the false lumen status on clinical outcomes in patients with acute type B aortic dissection.

S. Okumura, T. Murohara, H. Ishii, 2014, Journal of vascular surgery.

Clinical outcome of implantable cardioverter defibrillators with recalled and non-recalled leads in Japanese patients. Increased failure rate of the Sprint Fidelis lead.

S. Okumura, M. Hirai, T. Murohara, 2014, Circulation journal : official journal of the Japanese Circulation Society.

Temporary Adjunctive Cilostazol vs Clopidogrel Loading for ST-segment Elevation Acute Myocardial Infarction

S. Okumura, T. Murohara, H. Ishii, 2014, American Journal of Cardiovascular Drugs.

Comparison of early outcomes after primary stenting in Japanese patients with acute myocardial infarction between clopidogrel and ticlopidine in concomitant use with proton-pump inhibitor.

S. Okumura, T. Murohara, H. Ishii, 2012, Journal of cardiology.

Effects of occlusal disharmony on susceptibility to atrial fibrillation in mice

S. Okumura, Y. Saeki, Yasumasa Mototani, 2020, Scientific Reports.

Vidarabine, an anti-herpes agent, prevents occlusal-disharmony-induced cardiac dysfunction in mice

S. Okumura, Yasumasa Mototani, Y. Ohnuki, 2021, The Journal of Physiological Sciences.

Increased expression of the adipocytokine omentin in the epicardial adipose tissue of coronary artery disease patients.

H. Funakubo, S. Okumura, T. Murohara, 2016, Atherosclerosis.

Role of β-adrenergic signaling in masseter muscle

S. Okumura, K. Shiozawa, Yoshiki Nakamura, 2019, PloS one.

Role of cyclic AMP sensor Epac1 in masseter muscle hypertrophy and myosin heavy chain transition induced by β2‐adrenoceptor stimulation

S. Okumura, Y. Ishikawa, Y. Saeki, 2014, The Journal of physiology.

Role of masseter muscle β₂-adrenergic signaling in regulation of muscle activity, myosin heavy chain transition, and hypertrophy.

E. Tanaka, S. Okumura, Y. Saeki, 2013, Journal of pharmacological sciences.

Effects of chronic Akt/mTOR inhibition by rapamycin on mechanical overload-induced hypertrophy and myosin heavy chain transition in masseter muscle.

S. Okumura, Y. Saeki, K. Shiozawa, 2013, Journal of pharmacological sciences.

Prevention of heart failure in mice by an antiviral agent that inhibits type 5 cardiac adenylyl cyclase.

S. Vatner, S. Okumura, Y. Ishikawa, 2012, American journal of physiology. Heart and circulatory physiology.

Protective Effects of Clenbuterol against Dexamethasone-Induced Masseter Muscle Atrophy and Myosin Heavy Chain Transition

S. Okumura, Y. Saeki, K. Shiozawa, 2015, PloS one.

Developmental changes in gene expression of Epac and its upregulation in myocardial hypertrophy.

S. Okumura, Y. Ishikawa, Xu Wang, 2007, American journal of physiology. Heart and circulatory physiology.

Mechanisms of desensitization to a PDE inhibitor (milrinone) in conscious dogs with heart failure.

S. Vatner, S. Okumura, Y. Ishikawa, 1999, American journal of physiology. Heart and circulatory physiology.

Colocalization of β‐adrenergic receptors and caveolin within the plasma membrane

S. Okumura, Y. Ishikawa, Manabu Yamamoto, 1999 .

Mechanisms of desensitization to a PDE inhibitor (milrinone) in conscious dogs with heart failure.

S. Vatner, S. Okumura, Y. Ishikawa, 1999, The American journal of physiology.

Impact of heart failure severity on bone mineral density among older patients with heart failure

Y. Otaka, Y. Aoyagi, S. Okumura, 2021, Heart and Vessels.

The risk of adverse cardiac events following minor surgery under discontinuation of all antiplatelet therapy in patients with prior drug-eluting stent implantation.

S. Okumura, T. Murohara, H. Ishii, 2014, International journal of cardiology.

Comparison of tissue characteristic between left main and non-left main coronary artery lesions--assessment using integrated backscatter intravascular ultrasound.

S. Okumura, M. Hayashi, T. Murohara, 2013, International journal of cardiology.

Role of TLR4 signaling on Porphyromonas gingivalis LPS-induced cardiac dysfunction in mice

S. Okumura, T. Matsubara, Yasumasa Mototani, 2021, bioRxiv.

Decreased serum osmolality promotes ductus arteriosus constriction.

S. Okumura, Y. Ishikawa, M. Taguri, 2014, Cardiovascular research.

Coupling of β1-adrenergic receptor to type 5 adenylyl cyclase and its physiological relevance in cardiac myocytes.

S. Okumura, Y. Ishikawa, Wenqian Cai, 2015, Biochemical and biophysical research communications.

High Efficiency Gene Transfer by Multiple Transfection Protocol

S. Okumura, Y. Ishikawa, J. Sadoshima, 1999, The Histochemical Journal.

Sigmoid colon cancer with an incidental diagnosis of Leriche syndrome successfully treated without inferior epigastric artery injury

S. Okumura, M. Ogawa, Naoto Mizumura, 2016 .

Effects of chronic Porphylomonas gingivalis lipopolysaccharide infusion on cardiac dysfunction in mice.

S. Okumura, K. Gomi, Yasumasa Mototani, 2021, Journal of oral biosciences.

Changes in caveolin subtype protein expression in aging rat organs

S. Okumura, J. Kawabe, Y. Ishikawa, 2001, Molecular and Cellular Endocrinology.

Differential Regulation of Vascular Tone and Remodeling via Stimulation of Type 2 and Type 6 Adenylyl Cyclases in the Ductus Arteriosus

S. Okumura, K. Iwatsubo, Y. Ishikawa, 2010, Circulation research.

Activator of G Protein Signaling 8 (AGS8) Is Required for Hypoxia-induced Apoptosis of Cardiomyocytes

T. Honda, S. Okumura, Y. Ishikawa, 2009, The Journal of Biological Chemistry.

Downregulation of caveolin expression by cAMP signal.

S. Okumura, Y. Ishikawa, C. Schwencke, 1999, Life sciences.

Continuous Administration of Vancomycin through a Long Intestinal Tube for Clostridium difficile Infection.

S. Okumura, M. Kameyama, M. Ogawa, 2015, Internal medicine.

How the histamine N-methyltransferase inhibitor metoprine alleviates methamphetamine reward

F. S. Hall, G. Uhl, S. Okumura, 2017 .

Epac activation inhibits IL-6-induced cardiac myocyte dysfunction

S. Okumura, Y. Ishikawa, Meihua Jin, 2016, The Journal of Physiological Sciences.

Effects of protein kinase a on the phosphorylation status and transverse stiffness of cardiac myofibrils.

S. Okumura, Y. Saeki, K. Shiozawa, 2013, Journal of pharmacological sciences.

A Case of Gastrointenstinal Hemorrhage Caused by Invasion of the Duodenum by a Pancreatic Neuroendocrine Tumor

S. Okumura, M. Kameyama, M. Ogawa, 2014 .

Effects of occlusal disharmony on cardiac fibrosis, myocyte apoptosis and myocyte oxidative DNA damage in mice

S. Okumura, Y. Saeki, Yasuharu Amitani, 2020, PloS one.

The iron chelating agent, deferoxamine detoxifies Fe(Salen)-induced cytotoxicity.

S. Okumura, Y. Ishikawa, M. Taguri, 2017, Journal of pharmacological sciences.

Ascitic fluid with ammonia odor as a symptom of bladder rupture

S. Okumura, M. Ogawa, Naoto Mizumura, 2016, Acute medicine & surgery.

Gender differences in eating behavior and masticatory performance: An analysis of the Three-Factor-Eating Questionnaire and its association with body mass index in healthy subjects.

S. Okumura, K. Shiozawa, Yasumasa Mototani, 2020, Journal of oral biosciences.

Disruption of type 5 adenylyl cyclase gene preserves cardiac function against pressure overload

Jing Liu, Guiping Yang, Yoshihiro Ishikawa, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Disruption of type 5 adenylyl cyclase negates the developmental increase in Gαolf expression in the striatum

T. Iwamoto, S. Okumura, K. Iwatsubo, 2004, FEBS letters.

Identification of Transcription Factor E3 (TFE3) as a Receptor-independent Activator of Gα16

S. Okumura, Y. Ishikawa, M. Hiraoka, 2011, The Journal of Biological Chemistry.

The role of Epac in the heart

S. Okumura, Y. Ishikawa, M. Umemura, 2017, Cellular and Molecular Life Sciences.

Type 5 Adenylyl Cyclase Disruption Alters Not Only Sympathetic But Also Parasympathetic and Calcium-Mediated Cardiac Regulation

S. Vatner, S. Okumura, J. Kawabe, 2003, Circulation research.

Effect of cardiac rehabilitation on circulating microRNA expression in heart failure: a preliminary study

E. Saitoh, S. Okumura, M. Hayashi, 2020, Fujita medical journal.

Inhibition of EP4 Signaling Attenuates Aortic Aneurysm Formation

S. Okumura, Y. Ishikawa, Y. Sugimoto, 2012, PloS one.

Disruption of Type 5 Adenylyl Cyclase Enhances Desensitization of Cyclic Adenosine Monophosphate Signal and Increases Akt Signal With Chronic Catecholamine Stress

Reiko Kurotani, Stephen F. Vatner, Yoshihiro Ishikawa, 2007, Circulation.

Compartmentation of cyclic adenosine 3',5'-monophosphate signaling in caveolae.

S. Okumura, Y. Toya, Y. Ishikawa, 1999, Molecular endocrinology.

Caveolin gene transfer improves glucose metabolism in diabetic mice.

Reiko Kurotani, Susumu Minamisawa, Utako Yokoyama, 2010, American journal of physiology. Cell physiology.

Vidarabine, an anti-herpesvirus agent, prevents catecholamine-induced arrhythmias without adverse effect on heart function in mice

S. Okumura, Y. Ishikawa, B. Knollmann, 2018, Pflügers Archiv - European Journal of Physiology.

Norepinephrine-Induced Adrenergic Activation Strikingly Increased the Atrial Fibrillation Duration through β1- and α1-Adrenergic Receptor-Mediated Signaling in Mice

S. Okumura, Y. Ishikawa, Wenqian Cai, 2015, PloS one.

Trends in physiological coagulation factors in Japanese patients receiving novel oral anticoagulants

S. Okumura, T. Murohara, T. Amano, 2016, Journal of arrhythmia.

Efficacy and Safety of Apixaban in the Patients Undergoing the Ablation of Atrial Fibrillation

S. Okumura, M. Hirai, T. Murohara, 2015, Pacing and clinical electrophysiology : PACE.

Feasibility and safety of uninterrupted dabigatran therapy in patients undergoing ablation for atrial fibrillation.

S. Okumura, M. Hirai, T. Murohara, 2015, Internal medicine.

Translocation of caveolin regulates stretch-induced ERK activity in vascular smooth muscle cells.

S. Okumura, J. Kawabe, Y. Ishikawa, 2004, American journal of physiology. Heart and circulatory physiology.

Effect of ascorbic acid on reactive oxygen species production in chemotherapy and hyperthermia in prostate cancer cells

S. Okumura, Y. Ishikawa, Tomoyuki Saito, 2012, The Journal of Physiological Sciences.

Relation of plasma indoxyl sulfate levels and estimated glomerular filtration rate to left ventricular diastolic dysfunction.

S. Okumura, M. Hayashi, T. Murohara, 2013, The American journal of cardiology.

Pharmacological stimulation of type 5 adenylyl cyclase stabilizes heart rate under both microgravity and hypergravity induced by parabolic flight.

S. Okumura, K. Iwatsubo, Y. Ishikawa, 2012, Journal of pharmacological sciences.

Circulating miR-489 as a potential new biomarker for idiopathic dilated cardiomyopathy

H. Naruse, S. Okumura, J. Ishii, 2020, Fujita medical journal.

Secretoglobin 3A2 Suppresses Bleomycin-induced Pulmonary Fibrosis by Transforming Growth Factor β Signaling Down-regulation*

D. Esposito, J. Ward, S. Okumura, 2011, The Journal of Biological Chemistry.

Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses.

T. Abe, H. Kiyonari, S. Okumura, 2014, The Journal of clinical investigation.

Relation of omega-3 fatty acid and C-reactive protein to peripheral artery disease in patients with coronary artery disease

S. Okumura, M. Hayashi, T. Murohara, 2014, Heart and Vessels.

Cardiac overexpression of Epac1 in transgenic mice rescues lipopolysaccharide-induced cardiac dysfunction and inhibits Jak-STAT pathway.

S. Okumura, Y. Ishikawa, K. Shiozawa, 2017, Journal of molecular and cellular cardiology.

Impact of cardiac resynchronization therapy-defibrillator implantation on the association between body mass index and prognosis in patients with heart failure

S. Okumura, M. Hirai, T. Murohara, 2015, Journal of Interventional Cardiac Electrophysiology.

Role of phosphodiesterase 4 expression in the Epac1 signaling‐dependent skeletal muscle hypertrophic action of clenbuterol

S. Okumura, Y. Ishikawa, Y. Saeki, 2016, Physiological reports.

Effects of chronic Porphyromonas gingivalis lipopolysaccharide infusion on skeletal muscles in mice

S. Okumura, Y. Ujiie, K. Shiozawa, 2019, The Journal of Physiological Sciences.

Protection of Cardiomyocytes from the Hypoxia-Mediated Injury by a Peptide Targeting the Activator of G-Protein Signaling 8

Abdullah Al Mamun, S. Okumura, Y. Ishikawa, 2014, PloS one.

Predictive impact of early mobilization on rehospitalization for elderly Japanese heart failure patients

E. Saitoh, Y. Aoyagi, S. Okumura, 2019, Heart and Vessels.

Prediction of difficult laparoscopic cholecystectomy for acute cholecystitis.

S. Okumura, Aya Itoh, M. Kameyama, 2017, The Journal of surgical research.

Use of dynamic CT attenuation value for diagnosis of acute gangrenous cholecystitis.

S. Okumura, Aya Itoh, M. Kameyama, 2016, The American journal of emergency medicine.

[Sigmoid colon cancer with intussusception prolapsing through the anus treated by elective laparoscopic radical surgery].

S. Okumura, M. Ogawa, K. Horii, 2018, Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology.

Usefulness of Exchanged Protein Directly Activated by cAMP (Epac)1-Inhibiting Therapy for Prevention of Atrial and Ventricular Arrhythmias in Mice.

S. Okumura, Y. Ishikawa, B. Knollmann, 2019, Circulation journal : official journal of the Japanese Circulation Society.

Prognostic Value of Albuminuria on Cardiovascular Outcomes After Elective Percutaneous Coronary Intervention.

S. Okumura, T. Murohara, H. Ishii, 2016, The American journal of cardiology.

Hyperthermia generated with ferucarbotran (Resovist®) in an alternating magnetic field enhances cisplatin-induced apoptosis of cultured human oral cancer cells

I. Tohnai, T. Iwai, K. Mitsudo, 2014, The Journal of Physiological Sciences.

Differential Roles of Epac in Regulating Cell Death in Neuronal and Myocardial Cells*

T. Abe, H. Kiyonari, S. Okumura, 2010, The Journal of Biological Chemistry.

Serum microRNA-126 and -223 as new-generation biomarkers for sarcoidosis in patients with heart failure.

H. Naruse, S. Okumura, J. Ishii, 2018, Journal of Cardiology.

The roles of cytochrome p450 in ischemic heart disease.

S. Okumura, T. Fujita, U. Yokoyama, 2011, Current drug metabolism.

Role of G protein-regulated inducer of neurite outgrowth 3 (GRIN3) in β-arrestin 2-Akt signaling and dopaminergic behaviors

S. Okumura, Yukiko Shimizu, T. Okamura, 2018, Pflügers Archiv - European Journal of Physiology.

Epac activation inhibits IL-6-induced cardiac myocyte dysfunction

S. Okumura, Y. Ishikawa, Meihua Jin, 2016, The Journal of Physiological Sciences.

Oscillation of cAMP and Ca2+ in cardiac myocytes: a systems biology approach

H. Kitano, Samik Ghosh, S. Okumura, 2015, The Journal of Physiological Sciences.

Type 5 adenylyl cyclase plays a major role in stabilizing heart rate in response to microgravity induced by parabolic flight.

S. Okumura, S. Umemura, Y. Ishikawa, 2008, Journal of applied physiology.

Genetic manipulation and functional analysis of cAMP signalling in cardiac muscle: implications for a new target of pharmacotherapy.

S. Okumura, K. Iwatsubo, Y. Ishikawa, 2005, Biochemical Society transactions.

Disruption of Epac1 protects the heart from adenylyl cyclase type 5-mediated cardiac dysfunction.

S. Okumura, Y. Ishikawa, Wenqian Cai, 2016, Biochemical and biophysical research communications.

Dopamine induces apoptosis in young, but not in neonatal, neurons via Ca2+-dependent signal.

S. Okumura, K. Iwatsubo, Y. Toya, 2007, American journal of physiology. Cell physiology.

Effects of food diameter on bite size per mouthful and chewing behavior

S. Okumura, Y. Saeki, K. Shiozawa, 2015, The Journal of Physiological Sciences.

[Usefulness of combining a immunological fecal occult blood test (latex method) with a chemical test (guaiac method)].

S. Okumura, O. Kinoshita, E. Hamajima, 1990, Gan no rinsho. Japan journal of cancer clinics.

Colocalization of beta-adrenergic receptors and caveolin within the plasma membrane.

S. Okumura, Y. Ishikawa, C. Schwencke, 1999, Journal of cellular biochemistry.

“Brief” Aripiprazole-induced Neuroleptic Malignant Syndrome with Symptoms that Only Lasted a Few Hours

S. Okumura, M. Ogawa, H. Maehira, 2017, Internal medicine.

Non‐traumatic bladder rupture showing less than 10 Hounsfield units of ascites

Naoto Mizumura, Masao Ogawa, S. Okumura, 2016, Acute medicine & surgery.

[Early Liver Metastases after Curative Surgery for StageⅠ Gastric Cancer with Neuroendocrine Differentiation-A Case Report].

S. Okumura, M. Kameyama, M. Ogawa, 2018, Gan to kagaku ryoho. Cancer & chemotherapy.

Differences in activated clotting time among uninterrupted anticoagulants during the periprocedural period of atrial fibrillation ablation.

S. Okumura, M. Hirai, T. Murohara, 2015, Heart rhythm.

Perforated Carcinoma in the Gastric Remnant: A Case of Conservative Treatment Prior to Successful Curative R0 Resection

S. Okumura, M. Kameyama, M. Ogawa, 2016, Case reports in surgery.

Immunodetection of adenylyl cyclase protein in tissues

S. Okumura, Y. Ishikawa, Manabu Yamamoto, 2000, Molecular and Cellular Endocrinology.