H. Ohba

发表

Age differences in phosphodiesterase type‐IV and its functional response to dopamine D1 receptor modulation in the living brain: A PET study in conscious monkeys

N. Harada, S. Nishiyama, H. Ohba, 2002, Synapse.

Effects of acute acetylcholinesterase inhibition on the cerebral cholinergic neuronal system and cognitive function: Functional imaging of the conscious monkey brain using animal PET in combination with microdialysis

S. Nishiyama, H. Ohba, Kengo Sato, 2004, Synapse.

Evaluation of 6-11C-Methyl-m-Tyrosine as a PET Probe for Presynaptic Dopaminergic Activity: A Comparison PET Study with β-11C-l-DOPA and 18F-FDOPA in Parkinson Disease Monkeys

N. Harada, H. Ohba, T. Kakiuchi, 2016, The Journal of Nuclear Medicine.

Pharmacokinetic Modeling of (R)-[11C]verapamil to Measure the P-Glycoprotein Function in Nonhuman Primates

R. Boellaard, N. Colabufo, A. van Waarde, 2020, Molecular pharmaceutics.

PET Imaging of Mitochondrial Complex I with 18F-BCPP-EF in the Brains of MPTP-Treated Monkeys

N. Harada, S. Nishiyama, H. Ohba, 2016, The Journal of Nuclear Medicine.

Imaging mitochondrial complex I activation during a vibrotactile stimulation: A PET study using [18F]BCPP-EF in the conscious monkey brain

Huafeng Liu, Feiyan Chen, H. Ohba, 2020, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Effects of acetaminophen on mitochondrial complex I activity in the rat liver and kidney: a PET study with 18F-BCPP-BF

H. Ohba, T. Kakiuchi, H. Tsukada, 2016, EJNMMI Research.

Cholinergic neuronal modulations affect striatal dopamine transporter activity: PET studies in the conscious monkey brain

N. Harada, S. Nishiyama, H. Ohba, 2001, Synapse.

Liposome-encapsulated hemoglobin ameliorates ischemic stroke in nonhuman primates: longitudinal observation.

H. Ohba, H. Tsukada, D. Fukumoto, 2013, Artificial organs.

Evaluation of 18F-BCPP-EF for mitochondrial complex 1 imaging in the brain of conscious monkeys using PET

N. Harada, H. Ohba, T. Kakiuchi, 2014, European Journal of Nuclear Medicine and Molecular Imaging.

An increase of sigma1 receptors in the aged monkey brain

Hideo Tsukada, Yuichi Kimura, Kiichi Ishiwata, 2003, Neurobiology of Aging.

Synthesis and evaluation of N-isopropyl-p-[11C]methylamphetamine as a novel cerebral blood flow tracer for positron emission tomography

K. Ishiwata, N. Harada, H. Ohba, 2020, EJNMMI Research.

Head-to-head comparison of (R)-[11C]verapamil and [18F]MC225 in non-human primates, tracers for measuring P-glycoprotein function

Lara Garcia Varela, R. Boellaard, N. Colabufo, 2021, European Journal of Nuclear Medicine and Molecular Imaging.

Targeting and anti-tumor efficacy of liposomal 5'-O-dipalmitoylphosphatidyl 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine in mice lung bearing B16BL6 melanoma.

S. Shuto, H. Ohba, H. Tsukada, 2001, Cancer letters.

Quantification of ONO-2952 Occupancy of 18-kDaTranslocator Protein in Conscious Monkey Brains using Positron Emission Tomography

H. Ohba, H. Tsukada, S. Katsumata, 2017, The Journal of Pharmacology and Experimental Therapeutics.

Quantification of ONO-2952 occupancy of translocator protein 18 kDa in conscious monkey brain using positron emission tomography

H. Ohba, H. Tsukada, S. Katsumata, 2016 .

Upregulation of cannabinoid receptor type 2, but not TSPO, in senescence-accelerated neuroinflammation in mice: a positron emission tomography study

S. Nishiyama, H. Ohba, T. Kakiuchi, 2019, Journal of Neuroinflammation.

Positron emission tomography imaging of renal mitochondria is a powerful tool in the study of acute and progressive kidney disease models.

H. Ohba, H. Tsukada, T. Shimada, 2020, Kidney international.

Application of PET with feedback injection control system for quantification of drug-induced effects on the brain function

N. Harada, H. Ohba, T. Kakiuchi, 2004 .

Synthesis of 6-[(11)C]methyl-m-tyrosine ([(11)C]6MemTyr) for dopamine synthesis imaging in living brain using PET.

H. Ohba, T. Kakiuchi, H. Tsukada, 2015, Bioorganic & medicinal chemistry.

In vivo alterations of mitochondrial activity and amyloidosis in early-stage senescence-accelerated mice: a positron emission tomography study

N. Harada, S. Nishiyama, H. Ohba, 2021, Journal of neuroinflammation.

In Vivo Elevation of Mitochondrial Activity and Amyloid Deposition, but Inversely Correlated, in Early-stage Senescence-Accelerated Mice: A Positron Emission Tomography Study

S. Nishiyama, H. Ohba, T. Kakiuchi, 2020 .

Sensitive and early detection of mitochondrial dysfunction in the liver of NASH model mice by PET imaging with 18F-BCPP-BF

S. Nishiyama, H. Ohba, T. Kakiuchi, 2018, EJNMMI Research.

Mitochondrial Complex I Deficit in the Olfactory Systems of Age-related Neurodegenerative Monkey Models: A PET Study using 18F-BCPP-EF

S. Nishiyama, H. Ohba, T. Kakiuchi, 2018 .

Comparing α7 nicotinic acetylcholine receptor binding, amyloid‐β deposition, and mitochondria complex‐I function in living brain: A PET study in aged monkeys

Hideo Tsukada, Hiroyuki Ohba, Shingo Nishiyama, 2015, Synapse.

Comparing amyloid-β deposition, neuroinflammation, glucose metabolism, and mitochondrial complex I activity in brain: a PET study in aged monkeys

N. Harada, S. Nishiyama, H. Ohba, 2014, European Journal of Nuclear Medicine and Molecular Imaging.

PET Imaging of Ischemia-Induced Impairment of Mitochondrial Complex I Function in Monkey Brain

N. Harada, S. Nishiyama, H. Ohba, 2014, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

N. Harada, S. Nishiyama, H. Ohba, 2001, Brain Research.

In vivo TSPO and cannabinoid receptor type 2 availability early in post-stroke neuroinflammation in rats: a positron emission tomography study

S. Nishiyama, H. Ohba, T. Kakiuchi, 2017, Journal of Neuroinflammation.

Reduction of dopamine D2/3 receptor binding in the striatum after a single administration of esketamine, but not R-ketamine: a PET study in conscious monkeys

K. Hashimoto, S. Nishiyama, H. Ohba, 2016, European Archives of Psychiatry and Clinical Neuroscience.

[11C]CHIBA-1001 as a Novel PET Ligand for α7 Nicotinic Receptors in the Brain: A PET Study in Conscious Monkeys

K. Hashimoto, M. Iyo, S. Nishiyama, 2008, PloS one.

Ketamine decreased striatal [11C]raclopride binding with no alterations in static dopamine concentrations in the striatal extracellular fluid in the monkey brain: Multiparametric PET studies combined with microdialysis analysis

N. Harada, S. Nishiyama, H. Ohba, 2000, Synapse.

Isoflurane anesthesia enhances the inhibitory effects of cocaine and GBR12909 on dopamine transporter: PET studies in combination with microdialysis in the monkey brain

Hideo Tsukada, Hiroyuki Ohba, Shingo Nishiyama, 1999, Brain Research.

Neuroprotection by a Central Nervous System–Type Prostacyclin Receptor Ligand Demonstrated in Monkeys Subjected to Middle Cerebral Artery Occlusion and Reperfusion: A Positron Emission Tomography Study

C. Yokoyama, H. Onoe, H. Ohba, 2006, Stroke.

LoudNoise Exposure during Activity and Neurogenesis in the Living Rat Brain:Preliminary Study

S. Nishiyama, H. Ohba, T. Kakiuchi, 2014 .

Effect of MPTP on Serotonergic Neuronal Systems and Mitochondrial Complex I Activity in the Living Brain: A PET Study on Conscious Rhesus Monkeys

S. Nishiyama, H. Ohba, T. Kakiuchi, 2017, The Journal of Nuclear Medicine.

Ketamine alters the availability of striatal dopamine transporter as measured by [11C]β‐CFT and [11C]β‐CIT‐FE in the monkey brain

Hideo Tsukada, Hiroyuki Ohba, Shingo Nishiyama, 2001 .

Ketamine alters the availability of striatal dopamine transporter as measured by [(11)C]beta-CFT and [(11)C]beta-CIT-FE in the monkey brain.

N. Harada, H. Ohba, H. Tsukada, 2001, Synapse.

Effect of Oxygen Affinity of Liposome‐Encapsulated Hemoglobin on Cerebral Ischemia and Reperfusion as Detected by Positron Emission Tomography in Nonhuman Primates

H. Ohba, T. Kakiuchi, H. Tsukada, 2017, Artificial organs.

Differential effects of stress on [11C]raclopride and [11C]MNPA binding to striatal D2/D3 dopamine receptors: A PET study in conscious monkeys

Hideo Tsukada, Hiroyuki Ohba, Shingo Nishiyama, 2011, Synapse.

Application of feedback‐controlled bolus plus infusion (FC‐B/I) method for quantitative PET imaging of dopamine transporters with [18F]β‐CFT‐FE in conscious monkey brain

N. Harada, H. Ohba, T. Kakiuchi, 2013, Synapse.

Pharmacokinetic Modeling of [18F]MC225 for Quantification of the P-Glycoprotein Function at the Blood–Brain Barrier in Non-Human Primates with PET

R. Boellaard, N. Colabufo, A. van Waarde, 2020, Molecular pharmaceutics.

Facilitation of dopaminergic neural transmission does not affect [11C]SCH23390 binding to the striatal D1 dopamine receptors, but the facilitation enhances phosphodiesterase type‐IV activity through D1 receptors: PET studies in the conscious monkey brain

N. Harada, S. Nishiyama, H. Ohba, 2001, Synapse.

In vivo TSPO and cannabinoid receptor type 2 availability early in post-stroke neuroinflammation in rats: a positron emission tomography study

S. Nishiyama, H. Ohba, T. Kakiuchi, 2017, Journal of Neuroinflammation.

Anatomical-Guided Attention Enhances Unsupervised PET Image Denoising Performance

Yasuomi Ouchi, Etsuji Yoshikawa, Hiroyuki Ohba, 2021, Medical Image Anal..

Effects of aging on 5‐HT1A receptors and their functional response to 5‐HT1a agonist in the living brain: PET study with [carbonyl‐11C]WAY‐100635 in conscious monkeys

N. Harada, S. Nishiyama, H. Ohba, 2001, Synapse.

Cholinergic Neuronal Modulation Alters Dopamine D2Receptor Availability In Vivo by Regulating Receptor Affinity Induced by Facilitated Synaptic Dopamine Turnover: Positron Emission Tomography Studies with Microdialysis in the Conscious Monkey Brain

N. Harada, S. Nishiyama, H. Ohba, 2000, The Journal of Neuroscience.

Is synaptic dopamine concentration the exclusive factor which alters the in vivo binding of [ 11 C ]raclopride?: PET studies combined with microdialysis in conscious monkeys

N. Harada, S. Nishiyama, H. Ohba, 1999, Brain Research.

Muscarinic Receptor Occupancy and Cognitive Impairment: A PET Study with [11C](+)3-MPB and Scopolamine in Conscious Monkeys

Hideo Tsukada, Hiroyuki Ohba, Shingo Nishiyama, 2011, Neuropsychopharmacology.

Age differences in muscarinic cholinergic receptors assayed with (+)N‐[11C]methyl‐3‐piperidyl benzilate in the brains of conscious monkeys

N. Harada, S. Nishiyama, H. Ohba, 2001, Synapse.

Hideo Tsukada, Masami Futatsubashi, Hiroyuki Ohba, 2002, Brain Research.

Potential of [18F]β‐CFT‐FE (2β‐carbomethoxy‐3β‐(4‐fluorophenyl)‐8‐(2‐[18F]fluoroethyl)nortropane) as a dopamine transporter ligand: A PET study in the conscious monkey brain

Hideo Tsukada, Hiroyuki Ohba, Takeharu Kakiuchi, 2004 .

Dynamic PET Image Denoising Using Deep Convolutional Neural Networks Without Prior Training Datasets

Fumio Hashimoto, Hideo Tsukada, Hiroyuki Ohba, 2019, IEEE Access.

Evaluation of PET ligands (+)N‐[11C]ethyl‐3‐piperidyl benzilate and (+)N‐[11C]propyl‐3‐piperidyl benzilate for muscarinic cholinergic receptors: A PET study with microdialysis in comparison with (+)N‐[11C]methyl‐3‐piperidyl benzilate in the conscious monkey brain

N. Harada, S. Nishiyama, H. Ohba, 2001, Synapse.

Dose–response and duration effects of acute administrations of cocaine and GBR12909 on dopamine synthesis and transporter in the conscious monkey brain: PET studies combined with microdialysis

Hideo Tsukada, Hiroyuki Ohba, Shingo Nishiyama, 2000, Brain Research.

Brain p3‐Alcβ peptide restores neuronal viability impaired by Alzheimer's amyloid β‐peptide

N. Harada, S. Nishiyama, H. Ohba, 2023, EMBO molecular medicine.

Early distribution of18 F‐labeled AAV9 vectors in the cerebrospinal fluid after intracerebroventricular or intracisternal magna infusion in non‐human primates

K. Kawai, Takeshi Nakajima, N. Harada, 2022, Journal of Gene Medicine.

Evaluation of novel PET ligands (+)N‐[11C]methyl‐3‐piperidyl benzilate ([11C](+)3‐MPB) and its stereoisomer [11C](‐)3‐MPB for muscarinic cholinergic receptors in the conscious monkey brain: A PET study in comparison with [11C]4‐MPB

J. Hatazawa, S. Miura, T. Okudera, 2001, Synapse.

Potential of [(18)F]beta-CFT-FE (2beta-carbomethoxy-3beta-(4-fluorophenyl)-8-(2-[(18)F]fluoroethyl)nortropane) as a dopamine transporter ligand: A PET study in the conscious monkey brain.

N. Harada, H. Ohba, T. Kakiuchi, 2004, Synapse.

Development of novel PET probe [11C](R,R)HAPT and its stereoisomer [11C](S,S)HAPT for vesicular acetylcholine transporter imaging: A PET study in conscious monkey

S. Nishiyama, H. Ohba, H. Tsukada, 2014, Synapse.

Upregulation of cannabinoid receptor type 2, but not TSPO, in senescence-accelerated neuroinflammation in mice: a positron emission tomography study

S. Nishiyama, H. Ohba, T. Kakiuchi, 2019, Journal of Neuroinflammation.

Loud noise exposure during activity & neurogenesis in the living rat brain : A preliminary study 1 Title Loud noise exposure during activity and neurogenesis in the living rat brain : A preliminary study Authors

S. Nishiyama, H. Ohba, T. Kakiuchi, 2014 .

Ketamine/xylazine anesthesia alters [11C]MNPA binding to dopamine D2 receptors and response to methamphetamine challenge in monkey brain

Hideo Tsukada, Hiroyuki Ohba, Shingo Nishiyama, 2009, Synapse.

Hideo Tsukada, Hiroyuki Ohba, Shingo Nishiyama, 2000, Brain Research.

Subanesthetic Doses of Ketamine Transiently Decrease Serotonin Transporter Activity: A PET Study in Conscious Monkeys

Hideo Tsukada, Hiroyuki Ohba, Shingo Nishiyama, 2013, Neuropsychopharmacology.

Denoising of Dynamic Sinogram by Image Guided Filtering for Positron Emission Tomography

F. Hashimoto, H. Ohba, K. Ote, 2018, IEEE Transactions on Radiation and Plasma Medical Sciences.

Biodistribution assessment of cationic pullulan nanogel, a nasal vaccine delivery system, in mice and non-human primates.

H. Kiyono, N. Harada, H. Ohba, 2023, Vaccine.

Targeting of the Adenosine Receptors as A Novel Strategy for the Treatment of Arterial Hypertension

S. Nishiyama, H. Ohba, T. Kakiuchi, 2014 .

Omission of serial arterial blood sampling for quantitative analysis of monkey PET data using independent component analysis-based method

H. Tsukada, Y. Kimura, K. Ishiwata, 2007, 2007 IEEE Nuclear Science Symposium Conference Record.

Effect of oxybutynin and imidafenacin on central muscarinic receptor occupancy and cognitive function: A monkey PET study with [11C](+)3-MPB

Hideo Tsukada, Shuji Maruyama, Hiroyuki Ohba, 2011, NeuroImage.

4D deep image prior: dynamic PET image denoising using an unsupervised four-dimensional branch convolutional neural network

Akihiro Kakimoto, Fumio Hashimoto, Yasuomi Ouchi, 2020, Physics in medicine and biology.

Validation of reference tissue model of PET ligand [11C](+)3‐MPB for the muscarinic cholinergic receptor in the living brain of conscious monkey

S. Nishiyama, H. Ohba, H. Tsukada, 2011, Synapse.