B. O'dowd

发表

Human dopamine D1 receptor encoded by an intronless gene on chromosome 5

R. Rozmahel, J. Kennedy, R. Sunahara, 1990, Nature.

Spatial learning deficit in dopamine D(1) receptor knockout mice.

D. Sibley, P. Fletcher, B. O'dowd, 1999, European journal of pharmacology.

Discovery of a receptor related to the galanin receptors

B. O'dowd, G. O'neill, S. George, 1999, FEBS letters.

Novel GPCRs and their endogenous ligands: expanding the boundaries of physiology and pharmacology.

L. F. Kolakowski, B. O'dowd, S. George, 1999, Trends in pharmacological sciences.

The Dopamine D1–D2 Receptor Heteromer in Striatal Medium Spiny Neurons: Evidence for a Third Distinct Neuronal Pathway in Basal Ganglia

B. O'dowd, S. George, M. Perreault, 2011, Front. Neuroanat..

Insights into the Role of Dopamine Receptor Systems in Learning and Memory

B. O'dowd, M. El-Ghundi, S. George, 2007, Reviews in the neurosciences.

Modification of dopamine D(1) receptor knockout phenotype in mice lacking both dopamine D(1) and D(3) receptors.

P. Fletcher, B. O'dowd, M. El-Ghundi, 2000, European journal of pharmacology.

Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1

Susan R. George, Philip Seeman, Roger K. Sunahara, 1991, Nature.

Dopamine D2 receptor dimers and receptor-blocking peptides.

P. Seeman, M. Brann, B. O'dowd, 1996, Biochemical and biophysical research communications.

Lack of association between schizophrenia and alleles of the dopamine D1, D2, D3 and D4 receptor loci1

S. Cichon, H. Möller, M. Rietschel, 1993 .

Structural, Functional, and Genetic Aspects of Receptors Coupled to G-Proteins

M. Caron, R. Lefkowitz, B. O'dowd, 1992 .

Desensitization of the Dopamine D1 and D2 Receptor Hetero-Oligomer Mediated Calcium Signal by Agonist Occupancy of Either Receptor

B. O'dowd, S. George, C. H. So, 2007, Molecular Pharmacology.

A mutation of the beta 2-adrenergic receptor impairs agonist activation of adenylyl cyclase without affecting high affinity agonist binding. Distinct molecular determinants of the receptor are involved in physical coupling to and functional activation of Gs.

M. Caron, R. Lefkowitz, B. O'dowd, 1990, The Journal of biological chemistry.

The fate of the internalized apelin receptor is determined by different isoforms of apelin mediating differential interaction with beta-arrestin.

B. O'dowd, S. George, S. Ferguson, 2010, Biochemical and biophysical research communications.

Dopamine Receptor Oligomerization Visualized in Living Cells*

B. O'dowd, A. Rashid, S. George, 2005, Journal of Biological Chemistry.

Dopamine D2 receptor dimers in human and rat brain

P. Seeman, B. O'dowd, S. George, 1998, FEBS letters.

Inhibition of cell surface expression by mutant receptors demonstrates that D2 dopamine receptors exist as oligomers in the cell.

H. Akil, B. O'dowd, S. George, 2000, Molecular pharmacology.

The Role of Oligomerization in G Protein-Coupled Receptor Maturation

B. O'dowd, S. George, C. H. So, 2005 .

The splice variant D3nf reduces ligand binding to the D3 dopamine receptor: evidence for heterooligomerization.

B. O'dowd, S. George, Z. Xie, 2000, Brain research. Molecular brain research.

Phosphorylation and Palmitoylation of the Human D2L Dopamine Receptor in Sf9 Cells

M. Caron, M. Brann, B. O'dowd, 1994, Journal of neurochemistry.

CHAPTER 13 – Structure and Function of Adrenergic Receptors: Models for Understanding G Protein-Coupled Receptors

M. Caron, H. Dohlman, B. Kobilka, 1990 .

The β2 subunit of human placenta hexosaminidase (Hex) A and B is a non-random association of the two polypeptides αa and βb

B. O'dowd, D. Mahuran, J. Lowden, 1984 .

Unravelling the roles of the apelin system: prospective therapeutic applications in heart failure and obesity.

B. O'dowd, S. George, Dennis K. Lee, 2006, Trends in pharmacological sciences.

Disruption of dopamine D1 receptor gene expression attenuates alcohol-seeking behavior.

D. Sibley, P. Fletcher, B. O'dowd, 1998, European journal of pharmacology.

Dopamine D1 receptor distribution in Sf9 cells imaged by confocal microscopy: a quantitative evaluation.

J. Stevens, B. O'dowd, S. George, 1995, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Dopamine D1 receptor mutagenesis: role of amino acids in agonist and antagonist binding.

P. Seeman, B. O'dowd, S. George, 1993, Biochemical and biophysical research communications.

Continued discovery of ligands for G protein-coupled receptors.

B. O'dowd, S. George, Dennis K. Lee, 2003, Life sciences.

Discovery of three novel G-protein-coupled receptor genes.

H. Heng, L. F. Kolakowski, B. O'dowd, 1998, Genomics.

Mutations of the human beta 2-adrenergic receptor that impair coupling to Gs interfere with receptor down-regulation but not sequestration.

M. Caron, R. Lefkowitz, B. O'dowd, 1991, Molecular pharmacology.

Two distinct pathways for cAMP-mediated down-regulation of the beta 2-adrenergic receptor. Phosphorylation of the receptor and regulation of its mRNA level.

M. Caron, B. Kobilka, R. Lefkowitz, 1989, The Journal of biological chemistry.

Non-amine-based dopamine transporter (reuptake) inhibitors retain properties of amine-based progenitors.

B. O'dowd, R. De La Garza, S. George, 2003, European journal of pharmacology.

Cloning, Expression, and Chromosomal Localization of the Human Uridine Nucleotide Receptor Gene (*)

J. T. Turner, H. Heng, B. O'dowd, 1995, The Journal of Biological Chemistry.

Distinct distributions of mu, delta and kappa opioid receptor mRNA in rat brain.

B. O'dowd, S. George, R. Cheng, 1994, Biochemical and biophysical research communications.

Cloning genes encoding receptors related to chemoattractant receptors.

H. Heng, L. F. Kolakowski, B. O'dowd, 1998, Genomics.

A novel human gene encoding a G-protein-coupled receptor (GPR15) is located on chromosome 3.

H. Heng, B. O'dowd, S. George, 1996, Genomics.

Human serotonin1B receptor expression in Sf9 cells: phosphorylation, palmitoylation, and adenylyl cyclase inhibition.

M. Caron, B. O'dowd, S. George, 1993, Biochemistry.

Discovery of the first nonpeptide agonist of the GPR14/urotensin-II receptor: 3-(4-chlorophenyl)-3-(2- (dimethylamino)ethyl)isochroman-1-one (AC-7954).

U. Hacksell, D. Weiner, M. Brann, 2002, Journal of medicinal chemistry.

Adrenergic receptor homologies in vertebrate and invertebrate species examined by DNA hybridization.

M. Caron, J. Palacios, R. Lefkowitz, 1989, Life sciences.

Cloning of human genes encoding novel G protein-coupled receptors.

H. Heng, L. Tsui, B. O'dowd, 1994, Genomics.

Disruption of the mu-delta opioid receptor heteromer.

B. O'dowd, S. George, Xiaodong Ji, 2012, Biochemical and biophysical research communications.

Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8

A. Yamanaka, T. Sakurai, B. O'dowd, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Isolation of cDNA clones coding for the alpha-subunit of human beta-hexosaminidase. Extensive homology between the alpha- and beta-subunits and studies on Tay-Sachs disease.

H. Willard, B. O'dowd, M. Anderson, 1986, The Journal of biological chemistry.

Molecular Characterization and Expression of Cloned Human Galanin Receptors GALR2 and GALR3

L. F. Kolakowski, B. O'dowd, S. Kargman, 1998, Journal of neurochemistry.

Discovery of a novel human G protein-coupled receptor gene (GPR25) located on chromosome 1.

H. Heng, L. F. Kolakowski, B. O'dowd, 1997, Biochemical and biophysical research communications.

Enhanced Brain-Derived Neurotrophic Factor Signaling in the Nucleus Accumbens of Juvenile Rats

B. O'dowd, S. George, M. Perreault, 2013, Developmental Neuroscience.

Using Ligand-Induced Conformational Change to Screen for Compounds Targeting G-Protein-Coupled Receptors

B. O'dowd, S. George, R. Eglen, 2007, Journal of biomolecular screening.

B. O'dowd, S. George, Dennis K. Lee, 1999, Brain research. Molecular brain research.

Substitution of an extracellular cysteine in the beta 2-adrenergic receptor enhances agonist-promoted phosphorylation and receptor desensitization.

M. Caron, S. Liggett, R. Lefkowitz, 1989, Biochemical and biophysical research communications.

μ-δ opioid receptor heteromer-specific signaling in the striatum and hippocampus.

B. O'dowd, S. George, N. Kabli, 2014, Biochemical and biophysical research communications.

Identification of a Molecular Target of Psychosine and Its Role in Globoid Cell Formation

B. O'dowd, D. Im, K. Lynch, 2001, The Journal of cell biology.

Repeat sequences in the gene encoding the human D4 dopamine receptor.

B. O'dowd, 1992, Gene.

Separation and reformation of cell surface dopamine receptor oligomers visualized in cells.

B. O'dowd, S. George, Tuan V. Nguyen, 2011, European journal of pharmacology.

Characterization of the human 5-hydroxytryptamine1B receptor.

R. Rozmahel, J. Palacios, G. Mengod, 1992, The Journal of biological chemistry.

Agonist-Induced Cell Surface Trafficking of an Intracellularly Sequestered D1 Dopamine Receptor Homo-Oligomer

B. O'dowd, S. George, Michael M. C. Kong, 2006, Molecular Pharmacology.

Agonist-induced desensitization of dopamine D1 receptor-stimulated adenylyl cyclase activity is temporally and biochemically separated from D1 receptor internalization.

J. Stevens, B. O'dowd, S. George, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Reduced striatal dopamine D1–D2 receptor heteromer expression and behavioural subsensitivity in juvenile rats

B. O'dowd, S. George, M. Perreault, 2012, Neuroscience.

G-Protein-coupled receptor oligomerization and its potential for drug discovery

Susan R. George, B. O'dowd, S. George, 2002, Nature Reviews Drug Discovery.

D5 dopamine receptor carboxyl tail involved in D5-D2 heteromer formation.

B. O'dowd, S. George, Xiaodong Ji, 2013, Biochemical and biophysical research communications.

Two amino acids in each of D1 and D2 dopamine receptor cytoplasmic regions are involved in D1-D2 heteromer formation.

B. O'dowd, S. George, Xiaodong Ji, 2012, Biochemical and biophysical research communications.

Oligomerization of μ- and δ-Opioid Receptors

B. O'dowd, S. George, G. Varghese, 2000, The Journal of Biological Chemistry.

Resistance of the dopamine D2L receptor to desensitization accompanies the up-regulation of receptors on to the surface of Sf9 cells.

P. Seeman, B. O'dowd, S. George, 1997, Endocrinology.

Agonist-induced Desensitization of the μ Opioid Receptor Is Determined by Threonine 394 Preceded by Acidic Amino Acids in the COOH-terminal Tail*

B. O'dowd, S. George, Y. Pak, 1997, The Journal of Biological Chemistry.

Phosphorylation sites on two domains of the beta 2-adrenergic receptor are involved in distinct pathways of receptor desensitization.

M. Caron, R. Lefkowitz, B. O'dowd, 1989, The Journal of biological chemistry.

Palmitoylation occurs at cysteine 347 and cysteine 351 of the dopamine D(1) receptor.

B. O'dowd, S. George, Z. Xie, 1999, European journal of pharmacology.

Agonist-induced, G protein-dependent and -independent down-regulation of the mu opioid receptor. The receptor is a direct substrate for protein-tyrosine kinase.

B. O'dowd, S. George, J. Wang, 1999, The Journal of biological chemistry.

Mapping studies of two G protein-coupled receptor genes: an amino acid difference may confer a functional variation between a human and rodent receptor.

B. O'dowd, S. George, A. Marchese, 1994, Biochemical and biophysical research communications.

D2 dopamine receptor homodimerization is mediated by multiple sites of interaction, including an intermolecular interaction involving transmembrane domain 4.

B. O'dowd, S. George, Samuel P. Lee, 2003, Biochemistry.

The cloning and chromosomal mapping of two novel human opioid-somatostatin-like receptor genes, GPR7 and GPR8, expressed in discrete areas of the brain.

H. Heng, L. Tsui, B. O'dowd, 1995, Genomics.

THE INTERMEDIATE HEXOSAMINIDASES OF PLACENTA AND THEIR RELATIONSHIP TO PRECURSOR PROCESSING

B. O'dowd, F. Tsui, D. Mahuran, 1984 .

The role of palmitoylation in directing dopamine D1 receptor internalization through selective endocytic routes.

B. O'dowd, S. George, Michael M. C. Kong, 2011, Biochemical and biophysical research communications.

Agonist-independent Nuclear Localization of the Apelin, Angiotensin AT1, and Bradykinin B2 Receptors*

B. O'dowd, S. George, S. Chemtob, 2004, Journal of Biological Chemistry.

G protein-coupled receptor-protein interactions

B. O'dowd, S. George, 2005 .

Postnatal maternal deprivation and pubertal stress have additive effects on dopamine D2 receptor and CaMKII beta expression in the striatum

B. O'dowd, S. George, G. Novak, 2013, International Journal of Developmental Neuroscience.

Discovery and mapping of ten novel G protein-coupled receptor genes.

Jilly F. Evans, B. O'dowd, J. Evans, 2001, Gene.

Family 1 G protein-coupled receptor function in the CNS Insights from gene knockout mice

B. O'dowd, S. George, J. Karasinska, 2003, Brain Research Reviews.

Oligomerization of mu- and delta-opioid receptors. Generation of novel functional properties.

B. O'dowd, S. George, S R George, 2000, The Journal of biological chemistry.

Ontogenic profile of the expression of the mu opioid receptor gene in the rat telencephalon and diencephalon: an in situ hybridization study

B. O'dowd, S. George, R. Quirion, 2000, Journal of Chemical Neuroanatomy.

Novel G-protein-coupled receptor genes expressed in the brain: continued discovery of important therapeutic targets

B. O'dowd, S. George, Dennis K. Lee, 2002, Expert opinion on therapeutic targets.

Altered patterns of agonist-stimulated cAMP accumulation in cells expressing mutant beta 2-adrenergic receptors lacking phosphorylation sites.

M. Caron, S. Liggett, R. Lefkowitz, 1989, Molecular pharmacology.

The human dopamine D5 receptor gene: cloning and characterization of the 5'-flanking and promoter region.

R. Tyndale, P. Seeman, H. Niznik, 1995, Biochemistry.

Site-directed mutagenesis of the cytoplasmic domains of the human beta 2-adrenergic receptor. Localization of regions involved in G protein-receptor coupling.

M. Caron, R. Lefkowitz, B. O'dowd, 1988, The Journal of biological chemistry.

Discovery of a novel member of the histamine receptor family.

V. Setola, B. Roth, D. A. Shapiro, 2001, Molecular pharmacology.

Structure of the adrenergic and related receptors.

M. Caron, R. Lefkowitz, B. O'dowd, 1989, Annual review of neuroscience.

Identification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brain.

H. Heng, B. O'dowd, S. George, 1999, Brain research. Molecular brain research.

D1–D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of Gq/11 in the striatum

B. O'dowd, A. Rashid, M. El-Ghundi, 2007, Proceedings of the National Academy of Sciences.

Oligosaccharide structure and amino acid sequence of the major glycopeptides of mature human beta-hexosaminidase.

B. O'dowd, D. Cumming, D. Mahuran, 1988, Biochemistry.

Molecular Heterogeneity in O-Variant GM2 Gangliosidosis

H. Willard, B. O'dowd, D. Mahuran, 1986 .

Lack of association between dopamine D1 and D2 receptor genes and bipolar affective disorder.

M. Nöthen, R. Fimmers, D. Grandy, 1992, The American journal of psychiatry.

The Dopamine D1 Receptors

Philip Seeman, Mark R. Brann, P. Seeman, 1992 .

The identification of NP25: a novel protein that is differentially expressed by neuronal subpopulations.

B. O'dowd, S. George, C. Liew, 1994, Brain research. Molecular brain research.

Characterization of the Human Cysteinyl Leukotriene 2 Receptor*

Jilly F. Evans, B. O'dowd, R. Stocco, 2000, The Journal of Biological Chemistry.

A cysteinyl leukotriene 2 receptor variant is associated with atopy in the population of Tristan da Cunha.

Jilly F. Evans, Arthur S Slutsky, K. Siminovitch, 2003, Pharmacogenetics.

Orphan G protein-coupled receptors in the CNS.

B. O'dowd, J. Evans, S. George, 2001, Current opinion in pharmacology.

Identification of four novel human G protein-coupled receptors expressed in the brain.

B. O'dowd, S. George, M. Brown, 2001, Brain research. Molecular brain research.

A novel gene codes for a putative G protein‐coupled receptor with an abundant expression in brain

H. Heng, L. F. Kolakowski, B. O'dowd, 1996, FEBS letters.

A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11.

H. Heng, L. Tsui, J. Kennedy, 1993, Gene.

The human serotonin 5-hydroxytryptamine1D receptor pseudogene is transcribed.

T. Branchek, B. O'dowd, S. George, 1995, Gene.

Dopamine D1 and D2 Receptor Co-activation Generates a Novel Phospholipase C-mediated Calcium Signal*

B. O'dowd, A. Rashid, S. George, 2004, Journal of Biological Chemistry.

Characterization of a human gene related to genes encoding somatostatin receptors

L. F. Kolakowski, B. O'dowd, S. George, 1996, FEBS letters.

Genotyping of mitochondrial aldehyde dehydrogenase locus of Native American Indians.

F. Rothhammer, Y. Israel, B. O'dowd, 1990, Alcoholism, clinical and experimental research.

Cloning of two additional catecholamine receptors from rat brain

P. Seeman, H. Niznik, Y. Israel, 1990, FEBS letters.

Human dopamine transporter gene: coding region conservation among normal, Tourette's disorder, alcohol dependence and attention-deficit hyperactivity disorder populations

E H Cook, E. Cook, D. Comings, 2000, Molecular Psychiatry.

Characterization of Apelin, the Ligand for the APJ Receptor

B. O'dowd, S. George, Dennis K. Lee, 2000, Journal of neurochemistry.

Heteromeric Dopamine Receptor Signaling Complexes: Emerging Neurobiology and Disease Relevance

B. O'dowd, S. George, M. Perreault, 2014, Neuropsychopharmacology.

Calcium signaling cascade links dopamine D1–D2 receptor heteromer to striatal BDNF production and neuronal growth

B. O'dowd, S. George, M. Perreault, 2009, Proceedings of the National Academy of Sciences.

Dopamine D1-D2 receptor heteromer signaling pathway in the brain: emerging physiological relevance

B. O'dowd, S. George, A. Hasbi, 2011, Molecular Brain.

Characterization of a Novel Sphingosine 1-Phosphate Receptor, Edg-8*

B. O'dowd, M. Rigby, G. Mcallister, 2000, The Journal of Biological Chemistry.

Molecular cloning and characterization of a lysophosphatidic acid receptor, Edg-7, expressed in prostate.

D. Theodorescu, B. O'dowd, S. George, 2000, Molecular pharmacology.

Heterogeneous tissue-specific transcription of dopamine receptor subtype messenger RNA in rat brain.

B. O'dowd, S. George, L. Laurier, 1994, Brain research. Molecular brain research.

Agonist-induced, G Protein-dependent and -independent Down-regulation of the μ Opioid Receptor

B. O'dowd, S. George, Jia Bei Wang, 1999, The Journal of Biological Chemistry.

Human dopamine D5 receptor pseudogenes.

D. Ward, D. Taruscio, J. Kennedy, 1991, Gene.

(Recombinant DNA; polymerase chain reaction; intronless gene; in situ hybridization; chromosome; G-protein-linked receptor; Southern blot)

D. Ward, D. Taruscio, J. Kennedy, 1991 .

Oligomerization of opioid receptors: generation of novel signaling units.

B. O'dowd, S. George, B. Levac, 2002, Current opinion in pharmacology.

Activation of calcium/calmodulin-dependent protein kinase IIα in the striatum by the heteromeric D1-D2 dopamine receptor complex

B. O'dowd, A. Rashid, S. George, 2010, Neuroscience.

Restoration of amphetamine-induced locomotor sensitization in dopamine D1 receptor-deficient mice

B. O'dowd, M. El-Ghundi, S. George, 2009, Psychopharmacology.

Deletion of dopamine D1 and D3 receptors differentially affects spontaneous behaviour and cocaine‐induced locomotor activity, reward and CREB phosphorylation

B. O'dowd, S. George, R. Cheng, 2005, The European journal of neuroscience.

Attenuation of sucrose reinforcement in dopamine D1 receptor deficient mice

B. O'dowd, M. El-Ghundi, S. George, 2003, The European journal of neuroscience.

Structure of Mammalian D1 and D5 Dopamine Receptors and Their Function and Regulation in Cells

B. O'dowd, S. George, L. Demchyshyn, 2003 .

Prolonged fear responses in mice lacking dopamine D1 receptor

B. O'dowd, M. El-Ghundi, S. George, 2001, Brain Research.

Modification of dopamine D1 receptor knockout phenotype in mice lacking both dopamine D1 and D3 receptors

P. Fletcher, B. O'dowd, M. El-Ghundi, 2000 .

Low endogenous dopamine function in brain predisposes to high alcohol preference and consumption: reversal by increasing synaptic dopamine.

C. Naranjo, B. O'dowd, S. George, 1995, The Journal of pharmacology and experimental therapeutics.

Genotypic differences in brain dopamine receptor function in the DBA/2J and C57BL/6J inbred mouse strains.

B. O'dowd, S. George, G. Ng, 1994, European journal of pharmacology.

Discovery of a null mutation in a human trace amine receptor gene.

P. Muglia, J. Kennedy, B. O'dowd, 2003, Genomics.

Dopamine supersensitivity correlates with D2High states, implying many paths to psychosis.

Philip Seeman, R. Palmiter, D. Grandy, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Serotonin 5‐HT1B and 5‐HT1D receptors form homodimers when expressed alone and heterodimers when co‐expressed

B. O'dowd, S. George, Samuel P. Lee, 1999, FEBS letters.

TRH-R2 exhibits similar binding and acute signaling but distinct regulation and anatomic distribution compared with TRH-R1.

B. O'dowd, W. Huang, S. George, 2000, Molecular endocrinology.

Palmitoylation of the human beta 2-adrenergic receptor. Mutation of Cys341 in the carboxyl tail leads to an uncoupled nonpalmitoylated form of the receptor.

M. Caron, R. Lefkowitz, B. O'dowd, 1989, The Journal of biological chemistry.

Discovery of three novel orphan G-protein-coupled receptors.

H. Heng, B. O'dowd, S. George, 1999, Genomics.

Novel human G-protein-coupled receptors.

B. O'dowd, S. George, W. Vanti, 2003, Biochemical and biophysical research communications.

Polymorphisms of the D4 dopamine receptor alleles in chronic alcoholism.

Y. Israel, B. O'dowd, S. George, 1993, Biochemical and biophysical research communications.

Modification of the terminal residue of apelin-13 antagonizes its hypotensive action.

B. O'dowd, S. George, Dennis K. Lee, 2005, Endocrinology.

Striatal development involves a switch in gene expression networks, followed by a myelination event: Implications for neuropsychiatric disease

B. O'dowd, S. George, G. Novak, 2013, Synapse.

Heteromerization of dopamine D2 receptors with dopamine D1 or D5 receptors generates intracellular calcium signaling by different mechanisms.

B. O'dowd, S. George, A. Hasbi, 2010, Current opinion in pharmacology.

Heterogeneity of Renin Alleles in Outbred Dahl Salt‐Sensitive (Brookhaven) Rats

B. O'dowd, J. Rapp, Brian F. O'Dowd, 1991, Hypertension.

Antidepressant-like and anxiolytic-like effects following activation of the μ-δ opioid receptor heteromer in the nucleus accumbens

B. O'dowd, S. George, G. Balboni, 2014, Molecular Psychiatry.

Mutation screening of the dopamine D1 receptor gene in Tourette's syndrome and alcohol dependent patients.

D. Comings, B. O'dowd, M. Thompson, 1998, American journal of medical genetics.

Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes.

H. Heng, L. F. Kolakowski, B. O'dowd, 1997, Gene.

Structures of Dopamine Receptors

B. O'dowd, 1993, Journal of neurochemistry.

A single amino-acid difference confers major pharmacological variation between human and rodent 5-HT1B receptors

B. O'dowd, S. Marsters, A. Ashkenazi, 1992, Nature.

Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine γ-lyase☆

Y. Israel, B. O'dowd, H. Orrego, 1992 .

D1 and D2 dopamine receptor mRNA in rat brain.

A. Levey, R. Sunahara, P. Seeman, 1991, Proceedings of the National Academy of Sciences of the United States of America.

A Transmembrane Domain-derived Peptide Inhibits D1 Dopamine Receptor Function without Affecting Receptor Oligomerization*

P. Seeman, B. O'dowd, S. George, 1998, The Journal of Biological Chemistry.

Structure and regulation of G protein-coupled receptors: the beta 2-adrenergic receptor as a model.

M. Caron, R. Lefkowitz, M. Lohse, 1991, Vitamins and hormones.

The influence of the renin gene on alcohol consumption in Dahl rats.

B. O'dowd, L. Grupp, 1991, Alcoholism, clinical and experimental research.

Opioids: molecular basis of action

B. O'dowd, S. George, B. Levac, 2001 .

Serotonin transporter gene polymorphisms in alcohol dependence.

D. Comings, B. O'dowd, M. Thompson, 2000, Alcohol.

Minireview: Diversity and complexity of signaling through peptidergic G protein-coupled receptors.

B. O'dowd, A. Rashid, S. George, 2004, Endocrinology.

Distinct Residues in the Carboxyl Tail Mediate Agonist-induced Desensitization and Internalization of the Human Dopamine D1 Receptor*

B. O'dowd, S. George, M. Lamey, 2002, The Journal of Biological Chemistry.

Elimination of palmitoylation sites in the human dopamine D1 receptor does not affect receptor-G protein interaction.

B. O'dowd, S. George, H. Jin, 1997, European journal of pharmacology.

Removal of phosphorylation sites from the β2-adrenergic receptor delays onset of agonist-promoted desensitization

M. Caron, B. Kobilka, R. Lefkowitz, 1988, Nature.

Dopamine D1-D2 Receptor Heteromer-mediated Calcium Release Is Desensitized by D1 Receptor Occupancy with or without Signal Activation

B. O'dowd, S. George, A. Hasbi, 2010, The Journal of Biological Chemistry.

Regulation of Dopamine Receptor Trafficking and Responsiveness

B. O'dowd, S. George, M. Perreault, 2010 .

Regulation of D1 Dopamine Receptor Trafficking and Signaling by Caveolin-1

Susan R. George, B. O'dowd, S. George, 2007, Molecular Pharmacology.

D1 and D2 Dopamine Receptors Form Heterooligomers and Cointernalize after Selective Activation of Either Receptor

B. O'dowd, S. George, Tuan V. Nguyen, 2005, Molecular Pharmacology.

Desensitization, phosphorylation and palmitoylation of the human dopamine D1 receptor.

M. Caron, B. O'dowd, S. George, 1994, European journal of pharmacology.

The Dopamine D1-D2 Receptor Heteromer Localizes in Dynorphin/Enkephalin Neurons

P. Fletcher, P. Seeman, B. O'dowd, 2010, The Journal of Biological Chemistry.

Oligomerization of Dopamine and Serotonin Receptors

B. O'dowd, S. George, Tuan V. Nguyen, 2000, Neuropsychopharmacology.

Role for the C-terminus in agonist-induced mu opioid receptor phosphorylation and desensitization.

G. Uhl, B. O'dowd, Y. Yu, 2000, Biochemistry.

A serotonin receptor gene (5HT1A) variant found in a Tourette's syndrome patient.

D. Comings, M. Brann, B. O'dowd, 1996, Biochemical and biophysical research communications.

Visualization of dopamine D1, D2 and D3 receptor mRNA's in human and rat brain

J. Palacios, G. Mengod, R. Sunahara, 1992, Neurochemistry International.

Visualization of a dopamine D1 receptor mRNA in human and rat brain.

J. Palacios, G. Mengod, R. Sunahara, 1991, Brain research. Molecular brain research.

CHAPTER 10 – Expression of G Protein-Coupled Receptors in Baculovirus/Sf9 Cells: Imaging Receptor Distribution by Confocal Fluorescence Microscopy

J. Stevens, B. O'dowd, S. George, 1994 .

Cloning and characterization of additional members of the G protein-coupled receptor family.

H. Heng, P. Seeman, B. O'dowd, 2000, Biochimica et biophysica acta.

Homo- and hetero-oligomerization of G protein-coupled receptors.

B. O'dowd, S. George, Susan R George, 2003, Life sciences.

Neuronal Gq/11-coupled dopamine receptors: an uncharted role for dopamine.

B. O'dowd, A. Rashid, S. George, 2007, Trends in pharmacological sciences.

Calcium Signaling by Dopamine D5 Receptor and D5-D2 Receptor Hetero-Oligomers Occurs by a Mechanism Distinct from That for Dopamine D1-D2 Receptor Hetero-Oligomers

B. O'dowd, A. Rashid, S. George, 2009, Molecular Pharmacology.

Identification of the natural ligand of an orphan G-protein-coupled receptor involved in the regulation of vasoconstriction

Yumiko Saito, B. O'dowd, O. Civelli, 1999, Nature Cell Biology.

Isolation of cDNA clones coding for the beta subunit of human beta-hexosaminidase.

H. Willard, B. O'dowd, R. Korneluk, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Agonist-induced functional desensitization of the mu-opioid receptor is mediated by loss of membrane receptors rather than uncoupling from G protein.

B. O'dowd, S. George, M. Scheideler, 1996, Molecular pharmacology.

C. Austin, T. Mcdonald, B. O'dowd, 2001, Biochemical and biophysical research communications.

A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1.

L. F. Kolakowski, B. O'dowd, S. George, 1997, Biochemical and biophysical research communications.

Genotypic differences in mesolimbic enkephalin gene expression in DBA/2J and C57BL/6J inbred mice.

B. O'dowd, S. George, G. Ng, 1996, European journal of pharmacology.

A Role for the Distal Carboxyl Tails in Generating the Novel Pharmacology and G Protein Activation Profile of μ and δ Opioid Receptor Hetero-oligomers*

Susan R. George, B. O'dowd, S. George, 2005, Journal of Biological Chemistry.

Dopamine D1–D2 Receptor Heteromer in Dual Phenotype GABA/Glutamate-Coexpressing Striatal Medium Spiny Neurons: Regulation of BDNF, GAD67 and VGLUT1/2

B. O'dowd, S. George, M. Perreault, 2012, PloS one.

D 1 and D 2 dopamine receptor mRNA in rat brain ( striatum / substantia nigra / amygdala / septum / in situ hybridization )

A. Levey, R. Sunahara, P. Seeman, 2022 .

PstI RFLP in the human hexosaminidase (HEXB) gene on chromosome 5.

H. Willard, B. O'dowd, D. Mahuran, 1987, Nucleic acids research.

Activation of Dopamine D1-D2 Receptor Complex Attenuates Cocaine Reward and Reinstatement of Cocaine-Seeking through Inhibition of DARPP-32, ERK, and ΔFosB

A. Grace, P. Fletcher, B. O'dowd, 2018, Front. Pharmacol..

Molecular heterogeneity in the infantile and juvenile forms of Sandhoff disease (O-variant GM2 gangliosidosis).

H. Willard, B. O'dowd, D. Mahuran, 1986, The Journal of biological chemistry.

Mu-opioid receptor heterooligomer formation with the dopamine D1 receptor as directly visualized in living cells.

B. O'dowd, A. Rashid, S. George, 2008, European journal of pharmacology.

D1 dopamine receptor activity is not altered by a mutation in the first intracellular loop.

B. O'dowd, S. George, H. Jin, 1998, Biochimica et biophysica acta.

Trafficking of preassembled opioid μ-δ heterooligomer-Gz signaling complexes to the plasma membrane: Coregulation by agonists

B. O'dowd, A. Rashid, S. George, 2007 .

Trafficking of preassembled opioid mu-delta heterooligomer-Gz signaling complexes to the plasma membrane: coregulation by agonists.

B. O'dowd, A. Rashid, S. George, 2007, Biochemistry.

A physiological role for the dopamine D5 receptor as a regulator of BDNF and Akt signalling in rodent prefrontal cortex.

B. O'dowd, S. George, Jace Jones-Tabah, 2013, The international journal of neuropsychopharmacology.

Cloning, characterization, and distribution of a mu-opioid receptor in rat brain.

B. O'dowd, S. George, R. Cheng, 1994, Journal of neurochemistry.

A Novel Dopamine Receptor Signaling Unit in Brain: Heterooligomers of D1 And D2 Dopamine Receptors

B. O'dowd, S. George, 2007, TheScientificWorldJournal.

Blockade of G Protein-Coupled Receptors and the Dopamine Transporter by a Transmembrane Domain Peptide: Novel Strategy for Functional Inhibition of Membrane Proteins in Vivo

P. Seeman, B. O'dowd, C. Deber, 2003, Journal of Pharmacology and Experimental Therapeutics.

Cloning, Characterization, and Distribution of a μ‐Opioid Receptor in Rat Brain

B. O'dowd, S. George, Tuan V. Nguyen, 1994 .

Dopamine Receptor Homooligomers and Heterooligomers in Schizophrenia

B. O'dowd, S. George, M. Perreault, 2011, CNS neuroscience & therapeutics.

A peptide targeting an interaction interface disrupts the dopamine D1‐D2 receptor heteromer to block signaling and function in vitro and in vivo: effective selective antagonism

B. O'dowd, S. George, M. Perreault, 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Transcription of a human dopamine D5 pseudogene.

R. Sunahara, P. Seeman, B. O'dowd, 1991, Biochemical and biophysical research communications.

Two gene duplication events in the human and primate dopamine D5 receptor gene family.

H. Niznik, B. O'dowd, S. George, 1995, Gene.

Striatal development involves a switch in gene expression networks, followed by a myelination event: implications for neuropsychiatric disease

B. O'dowd, S. George, T. Fan, 2013 .

Resistance of the dopamine D2L receptor to desensitization accompanies the up-regulation of receptors on to the surface of Sf9 cells.

P. Seeman, B. O'dowd, S. George, 1997, Endocrinology.

Use of GPR1, GPR15, and STRL33 as coreceptors by diverse human immunodeficiency virus type 1 and simian immunodeficiency virus envelope proteins.

R. Doms, B. O'dowd, Benhur Lee, 1998, Virology.

An Alu sequence interrupts a human 5-hydroxytryptamine1D receptor pseudogene.

J. Kennedy, B. O'dowd, A. Petronis, 1993, Gene.

Effects of sedatives on GABA-mediated chloride flux into cerebral cortical microsacs prepared from emotional and non-emotional mice.

S. Mihic, B. O'dowd, P. Wu, 1992, European journal of pharmacology.

Reduced striatal dopamine D1–D2 receptor heteromer expression and behavioural subsensitivity in juvenile rats

B. O'dowd, M. Perreault, A. Hasbi, 2012, Neuroscience.

Striatal development involves a switch in gene expression networks, followed by a myelination event: Implications for neuropsychiatric disease

B. O'dowd, S. George, G. Novak, 2013, Synapse.

Oligomerization of m- and d-Opioid Receptors

B. O'dowd, S. George, G. Varghese, 2000 .

The Drosophila per gene homologs are expressed in mammalian suprachiasmatic nucleus and heart as well as in molluscan eyes.

H. Moldofsky, B. O'dowd, M. Ralph, 1992, Biochemical and biophysical research communications.

D1 and D2 Dopamine Receptors Form Heterooligomers and Co-internalize Following Selective Activation of Either Receptor ϕ

B. O'dowd, Michael M. C. Kong, Xiaodong Ji, 2022 .