R. Seifert

发表

The olfactory G protein Gαolf possesses a lower GDP‐affinity and deactivates more rapidly than Gsαshort: consequences for receptor‐coupling and adenylyl cyclase activation

Hui-yu Liu, K. Wenzel-Seifert, R. Seifert, 2001 .

The olfactory G protein G(alphaolf) possesses a lower GDP-affinity and deactivates more rapidly than G(salphashort): consequences for receptor-coupling and adenylyl cyclase activation.

K. Wenzel-Seifert, R. Seifert, H. Y. Liu, 2001, Journal of neurochemistry.

Computational and Experimental Analysis of the Transmembrane Domain 4/5 Dimerization Interface of the Serotonin 5-HT1A Receptor

M. Niv, R. Seifert, N. Kowalsman, 2012, Molecular Pharmacology.

Homology Model Adjustment and Ligand Screening with a Pseudoreceptor of the Human Histamine H4 Receptor

G. Schneider, H. Stark, R. Seifert, 2009, ChemMedChem.

Involvement of pyrimidinoceptors in the regulation of cell functions by uridine and by uracil nucleotides.

G. Schultz, R. Seifert, Roland Seifert, 1989, Trends in pharmacological sciences.

Dimeric carbamoylguanidine-type histamine H2 receptor ligands: A new class of potent and selective agonists.

R. Seifert, M. Keller, A. Buschauer, 2015, Bioorganic & medicinal chemistry.

Partial inhibition of human neutrophil activation by FK-506 at supratherapeutic concentrations

K. Wenzel-Seifert, R. Seifert, K. Wenzel‐Seifert, 1993, Naunyn-Schmiedeberg's Archives of Pharmacology.

Histamine H3 and H4 receptor affinity of branched 3-(1H-imidazol-4-yl)propyl N-alkylcarbamates.

H. Stark, K. Kieć‐Kononowicz, R. Seifert, 2009, Bioorganic & medicinal chemistry letters.

GPCR-Galpha fusion proteins: molecular analysis of receptor-G-protein coupling.

B. Kobilka, K. Wenzel-Seifert, R. Seifert, 1999, Trends in pharmacological sciences.

Differential coupling of the human cannabinoid receptors hCB1R and hCB2R to the G-protein Gαi2β1γ2

R. Seifert, J. Heilmann, Kathrin Nickl, 2008, Neuroscience Letters.

Adenylyl cyclases (ACs) (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

C. Dessauer, R. Seifert, R. Ostrom, 2019, IUPHAR/BPS Guide to Pharmacology CITE.

Chiral NG-acylated hetarylpropylguanidine-type histamine H2 receptor agonists do not show significant stereoselectivity.

R. Seifert, A. Buschauer, R. Geyer, 2010, Bioorganic & medicinal chemistry letters.

Non-targeted metabolomics by high resolution mass spectrometry in HPRT knockout mice.

R. Seifert, A. Kaever, V. Kaever, 2016, Life sciences.

Species-dependent activities of G-protein-coupled receptor ligands: lessons from histamine receptor orthologs.

Hans-Joachim Wittmann, A. Strasser, R. Seifert, 2013, Trends in pharmacological sciences.

Dissociations in the Effects of β2-Adrenergic Receptor Agonists on cAMP Formation and Superoxide Production in Human Neutrophils: Support for the Concept of Functional Selectivity

R. Seifert, A. Buschauer, M. Reinartz, 2013, PloS one.

Cyclosporin H Is a Potent and Selective Formyl Peptide Receptor Antagonist Comparison with Nt-Butoxycarbonyl-~-phenylalanyl-L-leucyl-L-phenylalanyl-1-leucyl-L-phenylalanine and Cyclosporins

K. Wenzel-Seifert, R. Seifert, K. Wenzel‐Seifert, 2001 .

Regulation of the superoxide-forming NADPH oxidase of human neutrophils is not altered in essential hypertension.

R. Seifert, A. Distler, G. Hilgenstock, 1991, Journal of hypertension.

Analysis by high-resolution two-dimensional electrophoresis of differentiation-dependent alterations in cytosolic protein pattern of HL-60 leukemic cells.

R. Seifert, P. Jungblut, Roland Seifert, 1990, Journal of biochemical and biophysical methods.

Effects of 39 Compounds on Calmodulin-Regulated Adenylyl Cyclases AC1 and Bacillus anthracis Edema Factor

R. Seifert, C. Lübker, 2015, PloS one.

Towards selective inhibitors of adenylyl cyclase toxin from Bordetella pertussis.

R. Seifert, S. Dove, 2012, Trends in microbiology.

Interactions of Bordetella pertussis adenylyl cyclase toxin CyaA with calmodulin mutants and calmodulin antagonists: comparison with membranous adenylyl cyclase I.

R. Seifert, Wei-Jen Tang, G. Lushington, 2012, Biochemical pharmacology.

NG‐Acylated Aminothiazolylpropylguanidines as Potent and Selective Histamine H2 Receptor Agonists

R. Seifert, A. Buschauer, G. Bernhardt, 2009, ChemMedChem.

No Evidence for Histamine H4 Receptor in Human Monocytes

R. Seifert, A. Buschauer, D. Neumann, 2014, The Journal of Pharmacology and Experimental Therapeutics.

The dual H3/4R antagonist thioperamide does not fully mimic the effects of the ‘standard’ H4R antagonist JNJ 7777120 in experimental murine asthma

R. Seifert, D. Neumann, S. Glage, 2013, Naunyn-Schmiedeberg's Archives of Pharmacology.

Molecular and cellular analysis of human histamine receptor subtypes.

A. Strasser, R. Seifert, A. Buschauer, 2013, Trends in pharmacological sciences.

Evidence for ligand-specific conformations of the histamine H(2)-receptor in human eosinophils and neutrophils.

R. Seifert, D. Neumann, Till M Reher, 2012, Biochemical pharmacology.

The bivalent ligand approach leads to highly potent and selective acylguanidine-type histamine H₂ receptor agonists.

R. Seifert, A. Buschauer, G. Bernhardt, 2012, Journal of medicinal chemistry.

Expression and functional properties of canine, rat, and murine histamine H4 receptors in Sf9 insect cells

R. Seifert, Patrick Igel, A. Buschauer, 2011, Naunyn-Schmiedeberg's Archives of Pharmacology.

Does the Histamine H4 Receptor Have a Pro- or Anti-Inflammatory Role in Murine Bronchial Asthma?

R. Seifert, D. Neumann, S. Beermann, 2010, Pharmacology.

N(G)-acylated imidazolylpropylguanidines as potent histamine H4 receptor agonists: selectivity by variation of the N(G)-substituent.

R. Seifert, Patrick Igel, A. Buschauer, 2009, Journal of medicinal chemistry.

Colors of Ag+-Exchanged Zeolite A

G. Calzaferri, R. Seifert, A. Rytz, 2000 .

Histamine H(1)- and H(4)-receptor signaling cooperatively regulate MAPK activation.

R. Seifert, A. Buschauer, D. Neumann, 2015, Biochemical pharmacology.

Particle Distribution in a Microporous Material

G. Calzaferri, R. Seifert, A. Kunzmann, 1999 .

Dynamic bias and its implications for GPCR drug discovery

R. Seifert, M. Michel, R. Bond, 2014, Nature Reviews Drug Discovery.

Regulation of G protein subunit composition in cardiomyocytes: pharmacological implications

R. Seifert, 2013, Naunyn-Schmiedeberg's Archives of Pharmacology.

R. Seifert, P. Han, F. Schweda, 2013, PloS one.

The therapeutic potential of histamine receptor ligands in inflammatory bowel disease.

R. Seifert, D. Neumann, 2014, Biochemical pharmacology.

Assessing the Use of the sGC Stimulator BAY-747, as a Potential Treatment for Duchenne Muscular Dystrophy

R. Seifert, A. Vakalopoulos, L. Dietz, 2021, International journal of molecular sciences.

Histamine H1-receptors in HL-60 monocytes are coupled to Gi-proteins and pertussis toxin-insensitive G-proteins and mediate activation of Ca2+ influx without concomitant Ca2+ mobilization from intracellular stores

G. Schultz, R. Seifert, L. Grünbaum, 1994, Naunyn-Schmiedeberg’s Archives of Pharmacology.

Stimulus-dependent inhibition of platelet aggregation by the protein kinase C inhibitors polymyxin B, H-7 and staurosporine.

R. Seifert, H. Osswald, C. Schächtele, 1988, Biochemical and biophysical research communications.

Cyclic cytidine 3′,5′‐monophosphate (cCMP) signals via cGMP kinase I

F. Hofmann, R. Seifert, J. Schlossmann, 2010, FEBS letters.

Point mutations in the second extracellular loop of the histamine H2 receptor do not affect the species-selective activity of guanidine-type agonists

R. Seifert, A. Buschauer, S. Dove, 2007, Naunyn-Schmiedeberg's Archives of Pharmacology.

In vivo Evidence for Partial Activation of Eosinophils via the Histamine H4-Receptor: Adoptive Transfer Experiments Using Eosinophils From H4R−/− and H4R+/+ Mice

R. Seifert, D. Neumann, Bastian Schirmer, 2018, Front. Immunol..

Differential inhibition of human neutrophil activation by cyclosporins A, D, and H. Cyclosporin H is a potent and effective inhibitor of formyl peptide-induced superoxide formation.

K. Wenzel-Seifert, R. Seifert, L. Grünbaum, 1991, Journal of immunology.

Cyclosporin H is a potent and selective formyl peptide receptor antagonist. Comparison with N-t-butoxycarbonyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L- leucyl-L-phenylalanine and cyclosporins A, B, C, D, and E.

K. Wenzel-Seifert, R. Seifert, K. Wenzel‐Seifert, 1993, Journal of immunology.

Defective Gi Protein Coupling in Two Formyl Peptide Receptor Mutants Associated with Localized Juvenile Periodontitis*

K. Wenzel-Seifert, R. Seifert, K. Wenzel‐Seifert, 2001, The Journal of Biological Chemistry.

High Constitutive Activity of the Human Formyl Peptide Receptor*

K. Wenzel-Seifert, R. Seifert, C. Hurt, 1998, The Journal of Biological Chemistry.

Synthesis and cannabinoid receptor activity of ketoalkenes from Echinacea pallida and nonnatural analogues.

R. Seifert, J. Heilmann, B. König, 2008, Chemistry.

Lack of Histamine H4-Receptor Expression Aggravates TNBS-Induced Acute Colitis Symptoms in Mice

R. Seifert, D. Neumann, Bastian Schirmer, 2017, Front. Pharmacol..

Proinflammatory role of the histamine H4 receptor in dextrane sodium sulfate-induced acute colitis.

R. Seifert, D. Neumann, Bastian Schirmer, 2015, Biochemical pharmacology.

Adenylyl cyclase regulation in heart failure due to myocardial infarction in rats

R. Seifert, Barbara E. Albrecht-Küpper, Jörg H. Bräunig, 2014, Naunyn-Schmiedeberg's Archives of Pharmacology.

Functional Adenylyl Cyclase Inhibition in Murine Cardiomyocytes by 2′(3′)-O-(N-Methylanthraniloyl)-Guanosine 5′-[γ-Thio]triphosphate

S. Vatner, R. Seifert, S. Herzig, 2007, Journal of Pharmacology and Experimental Therapeutics.

Generation of specific antibodies against the rap1A, rap1B and rap2 small GTP-binding proteins. Analysis of rap and ras proteins in membranes from mammalian cells.

G. Schultz, R. Seifert, R. Frank, 1992, European journal of biochemistry.

A liquid chromatography-coupled tandem mass spectrometry method for quantitation of cyclic di-guanosine monophosphate.

R. Seifert, U. Jenal, A. Böhm, 2010, Journal of microbiological methods.

Distinct Interactions of Human (cid:1) 1 - and (cid:1) 2 -Adrenoceptors with Isoproterenol, Epinephrine, Norepinephrine, and Dopamine

R. Seifert, Nina Weitl, 2008 .

Monovalent anions differentially modulate coupling of the beta2-adrenoceptor to G(s)alpha splice variants.

R. Seifert, 2001, The Journal of pharmacology and experimental therapeutics.

cUMP hydrolysis by PDE3A

R. Seifert, D. Hilfiker-Kleiner, V. Kaever, 2016, Naunyn-Schmiedeberg's Archives of Pharmacology.

N-protein kinase C isoenzymes may be involved in the regulation of various neutrophil functions.

K. Wenzel-Seifert, R. Seifert, C. Schächtele, 1994, Biochemical and biophysical research communications.

Activation of the β2-Adrenergic Receptor-Gαs Complex Leads to Rapid Depalmitoylation and Inhibition of Repalmitoylation of Both the Receptor and Gαs *

R. Seifert, S. Marullo, M. Bouvier, 1999, The Journal of Biological Chemistry.

Functional reconstitution of human neuropeptide Y (NPY) Y2 and Y4 receptors in Sf9 insect cells

R. Seifert, Patrick Igel, A. Buschauer, 2011, Journal of receptor and signal transduction research.

Frontiers in Medicinal Chemistry in Regensburg

R. Seifert, A. Buschauer, S. Dove, 2008, ChemMedChem.

Opposite Effects of Mepyramine on JNJ 7777120-Induced Amelioration of Experimentally Induced Asthma in Mice in Sensitization and Provocation

R. Seifert, D. Jonigk, D. Neumann, 2012, PloS one.

The histamine H4‐receptor (H4R) regulates eosinophilic inflammation in ovalbumin‐induced experimental allergic asthma in mice

R. Seifert, D. Wedekind, D. Neumann, 2015, European journal of immunology.

Rethinking Pharmacological Nomenclature.

R. Seifert, 2018, Trends in pharmacological sciences.

Unmasking different constitutive activity of four chemoattractant receptors using Na+ as universal stabilizer of the inactive (R) state.

K. Wenzel-Seifert, R. Seifert, K. Wenzel‐Seifert, 2001, Receptors & channels.

Histamine H(4) receptor-RGS fusion proteins expressed in Sf9 insect cells: a sensitive and reliable approach for the functional characterization of histamine H(4) receptor ligands.

R. Seifert, E. Schneider, 2009, Biochemical pharmacology.

From bedside to bench—meeting report of the 7th International Conference on cGMP “cGMP: generators, effectors and therapeutic implications” in Trier, Germany, from June 19th to 21st 2015

R. Seifert, A. Friebe, P. Sandner, 2015, Naunyn-Schmiedeberg's Archives of Pharmacology.

In U-937 promonocytes, misteltoe lectin I increases basal [Ca2+]i, enhances histamine H1- and complement C5a-receptor-mediated rises in [Ca2+]i, and induces cell death

K. Wenzel-Seifert, R. Seifert, H. Lentzen, 1997, Naunyn-Schmiedeberg's Archives of Pharmacology.

Different Effects of Gsα Splice Variants on β2-Adrenoreceptor-mediated Signaling

B. Kobilka, K. Wenzel-Seifert, R. Seifert, 1998, The Journal of Biological Chemistry.

Functional differences between human formyl peptide receptor isoforms 26, 98, and G6

K. Wenzel-Seifert, R. Seifert, K. Wenzel‐Seifert, 2003, Naunyn-Schmiedeberg's Archives of Pharmacology.

Multiple Differences in Agonist and Antagonist Pharmacology between Human and Guinea Pig Histamine H1-Receptor

T. Bürckstümmer, K. Wenzel-Seifert, R. Seifert, 2003, Journal of Pharmacology and Experimental Therapeutics.

Flow cytometric analysis with a fluorescently labeled formyl peptide receptor ligand as a new method to study the pharmacological profile of the histamine H2 receptor

R. Seifert, A. Buschauer, D. Neumann, 2015, Naunyn-Schmiedeberg's Archives of Pharmacology.

Fatty-acid-induced activation of NADPH oxidase in plasma membranes of human neutrophils depends on neutrophil cytosol and is potentiated by stable guanine nucleotides.

G. Schultz, R. Seifert, 1987, European journal of biochemistry.

Activation of GTP formation and high-affinity GTP hydrolysis by mastoparan in various cell membranes. G-protein activation via nucleoside diphosphate kinase, a possible general mechanism of mastoparan action.

R. Seifert, K. Laugwitz, J. F. Klinker, 1996, Biochemical pharmacology.

Complex regulation of human neutrophil activation by actin filaments: dihydrocytochalasin B and botulinum C2 toxin uncover the existence of multiple cation entry pathways

K. Wenzel-Seifert, R. Seifert, K. Aktories, 1997, Journal of leukocyte biology.

Guanine nucleotides stimulate NADPH oxidase in membranes of human neutrophils

G. Schultz, R. Seifert, W. Rosenthal, 1986, FEBS letters.

Differential interactions of G-proteins and adenylyl cyclase with nucleoside 5′-triphosphates, nucleoside 5′-[γ-thio]triphosphates and nucleoside 5′-[β,γ-imido]triphosphates

R. Seifert, T. Mou, G. Lushington, 2005 .

Concanavalin A and mistletoe lectin I differentially activate cation entry and exocytosis in human neutrophils: lectins may activate multiple subtypes of cation channels

K. Wenzel-Seifert, R. Seifert, D. Krautwurst, 1996, Journal of leukocyte biology.

Thapsigargin activates univalent- and bivalent-cation entry in human neutrophils by a SK&F I3 96365- and Gd3+-sensitive pathway and is a partial secretagogue: involvement of pertussis-toxin-sensitive G-proteins and protein phosphatases 1/2A and 2B in the signal-transduction pathway.

K. Wenzel-Seifert, R. Seifert, D. Krautwurst, 1996, The Biochemical journal.

Maitotoxin activates cation channels distinct from the receptor-activated non-selective cation channels of HL-60 cells.

G. Schultz, R. Seifert, I. Musgrave, 1994, The Biochemical journal.

Formyl peptides and ATP stimulate Ca2+ and Na+ inward currents through non-selective cation channels via G-proteins in dibutyryl cyclic AMP-differentiated HL-60 cells. Involvement of Ca2+ and Na+ in the activation of beta-glucuronidase release and superoxide production.

G. Schultz, R. Seifert, D. Krautwurst, 1992, The Biochemical journal.

Histamine increases cytosolic Ca2+ in dibutyryl-cAMP-differentiated HL-60 cells via H1 receptors and is an incomplete secretagogue.

R. Seifert, A. Buschauer, S. Offermanns, 1992, Molecular pharmacology.

The superoxide-forming NADPH oxidase of phagocytes. An enzyme system regulated by multiple mechanisms.

G. Schultz, R. Seifert, 1991, Reviews of physiology, biochemistry and pharmacology.

A simple mechanistic terminology of psychoactive drugs: a proposal

R. Seifert, Bastian Schirmer, 2020, Naunyn-Schmiedeberg's Archives of Pharmacology.

Incomplete functional differentiation of HL‐60 leukemic cells by synthetic lipopetides

D. Huhn, W. Bessler, R. Seifert, 1992 .

Examination of ligand-induced conformational changes in the beta2 adrenergic receptor.

B. Kobilka, R. Seifert, P. Ghanouni, 1998, Life Science.

The Effect of pH on β2 Adrenoceptor Function

S. Rasmussen, B. Kobilka, R. Seifert, 2000, The Journal of Biological Chemistry.

Modulation of histamine H3 receptor function by monovalent ions

R. Seifert, D. Schnell, 2010, Neuroscience Letters.

Search for novel, high affinity histamine H3 receptor ligands with fluorescent properties

H. Stark, K. Kuder, K. Kieć‐Kononowicz, 2010, Inflammation Research.

Apoptotic and anti-proliferative effect of guanosine and guanosine derivatives in HuT-78 T lymphoma cells

R. Seifert, E. Schneider, S. Kälble, 2020, Naunyn-Schmiedeberg's Archives of Pharmacology.

Activation and Inhibition of Adenylyl Cyclase Isoforms by Forskolin Analogs

R. Seifert, Cibele S. Pinto, T. Mou, 2008, Journal of Pharmacology and Experimental Therapeutics.

Effect of MANT-nucleotides on L-type calcium currents in murine cardiomyocytes

R. Seifert, S. Herzig, J. Matthes, 2011, Naunyn-Schmiedeberg's Archives of Pharmacology.

Differential interactions of the catalytic subunits of adenylyl cyclase with forskolin analogs.

S. Sprang, R. Seifert, Cibele S. Pinto, 2009, Biochemical pharmacology.

Synthesis and Pharmacological Properties of New Tetracyclic Forskolin Analogues

R. Seifert, B. König, Prantik Maity, 2009 .

Functionally nonequivalent interactions of guanosine 5'-triphosphate, inosine 5'-triphosphate, and xanthosine 5'-triphosphate with the retinal G-protein, transducin, and with Gi-proteins in HL-60 leukemia cell membranes.

R. Seifert, J. F. Klinker, 1997, Biochemical pharmacology.

G-protein α-subunits in cytosolic and membranous fractions of human neutrophils

R. Seifert, M. Bigalke, W. Rosenthal, 1989, Molecular and Cellular Endocrinology.

No Evidence for Functional Selectivity of Proxyfan at the Human Histamine H3 Receptor Coupled to Defined Gi/Go Protein Heterotrimers

R. Seifert, D. Schnell, K. Burleigh, 2010, Journal of Pharmacology and Experimental Therapeutics.

N-Alkenyl and cycloalkyl carbamates as dual acting histamine H3 and H4 receptor ligands.

H. Stark, J. Handzlik, K. Kieć‐Kononowicz, 2011, Bioorganic & medicinal chemistry.

Establishment of recombinant cannabinoid receptor assays and characterization of several natural and synthetic ligands

R. Seifert, J. Heilmann, E. Schneider, 2010, Naunyn-Schmiedeberg's Archives of Pharmacology.

Constitutive Activity and Ligand Selectivity of Human, Guinea Pig, Rat, and Canine Histamine H2 Receptors

R. Seifert, A. Buschauer, S. Dove, 2007, Journal of Pharmacology and Experimental Therapeutics.

Mutations of Cys-17 and Ala-271 in the Human Histamine H2 Receptor Determine the Species Selectivity of Guanidine-Type Agonists and Increase Constitutive Activity

R. Seifert, A. Buschauer, S. Dove, 2007, Journal of Pharmacology and Experimental Therapeutics.

Striking differences of action of lisuride stereoisomers at histamine H1 receptors

A. Strasser, R. Seifert, H. Pertz, 2006, Naunyn-Schmiedeberg's Archives of Pharmacology.

N1-(3-Cyclohexylbutanoyl)-N2-[3-(1H-imidazol-4-yl)propyl]guanidine (UR-AK57), a Potent Partial Agonist for the Human Histamine H1- and H2-Receptors

R. Seifert, A. Buschauer, S. Xie, 2006, Journal of Pharmacology and Experimental Therapeutics.

N 1-( 3-Cyclohexylbutanoyl )-N 2-[ 3-( 1 H-imidazol-4-yl ) propyl ] guanidine ( UR-AK 57 ) , a Potent Partial Agonist for the Human Histamine H 1-and H 2-Receptors

R. Seifert, A. Buschauer, S. Xie, 2006 .

Alpha 2A-adrenoceptors mediate activation of non-selective cation channels via Gi-proteins in human erythroleukaemia (HEL) cells. No evidence for a functional role of imidazoline receptors in modulating calcium.

R. Seifert, I. Musgrave, 1995, Biochemical Pharmacology.

Inhibitors of Bacillus anthracis edema factor.

R. Seifert, S. Dove, 2013, Pharmacology & therapeutics.

Nucleotidyl cyclase activity of soluble guanylyl cyclase α1β1.

J. Stasch, R. Seifert, V. Kaever, 2012, Biochemistry.

Allosteric Regulation of Nucleotidyl Cyclases: An Emerging Pharmacological Target

R. Seifert, K. Beste, 2012, Science Signaling.

Histamine inhibits activation of human neutrophils and HL-60 leukemic cells via H2-receptors

G. Schultz, R. Seifert, R. Burde, 1989, Naunyn-Schmiedeberg's Archives of Pharmacology.

Impact of fusion to Gαi2 and co‐expression with RGS proteins on pharmacological properties of human cannabinoid receptors CB1R and CB2R

R. Seifert, J. Heilmann, S. Sutor, 2011, The Journal of pharmacy and pharmacology.

Drug-Induced Arrhythmias and Drugs for the Treatment of Arrhythmias

R. Seifert, 2019, Basic Knowledge of Pharmacology.

Microsoft Word-47256044-file00

R. Thurmond, A. Strasser, R. Seifert, 2010 .

Differential inhibition and potentiation by cell-permeant analogues of cyclic AMP and cyclic GMP and NO-containing compounds of exocytosis in human neutrophils

K. Wenzel-Seifert, R. Seifert, J. Ervens, 1991, Naunyn-Schmiedeberg's Archives of Pharmacology.

The Role of Pseudomonas aeruginosa ExoY in an Acute Mouse Lung Infection Model

R. Seifert, A. Munder, Christina Kloth, 2018, Toxins.

Characterization of ligand-induced conformational states in the beta 2 adrenergic receptor.

B. Kobilka, R. Seifert, P. Ghanouni, 1999, Journal of receptor and signal transduction research.

Receptor-independent G protein activation may account for the stimulatory effects of first-generation H1-receptor antagonists in HL-60 cells, basophils, and mast cells.

R. Seifert, E. Dippel, R. Burde, 1996, Biochemical pharmacology.

Recruitment of β-Arrestin 1 and 2 to the β2-Adrenoceptor: Analysis of 65 Ligands

R. Seifert, M. Reinartz, T. Ozawa, 2015, The Journal of Pharmacology and Experimental Therapeutics.

Recruitment of b-Arrestin 1 and 2 to the b 2-Adrenoceptor : Analysis of 65 Ligands s

R. Seifert, M. Reinartz, T. Ozawa, 2015 .

Activation of NADPH Oxidase

G. Schultz, R. Seifert, 1991 .

G Protein-Coupled Receptors as Drug Targets: Analysis of Activation and Constitutive Activity

T. Wieland, R. Seifert, 2005 .

Fusion proteins as model systems for the analysis of constitutive GPCR activity.

R. Seifert, E. Schneider, 2010, Methods in enzymology.

Examining the efficiency of receptor/G‐protein coupling with a cleavable β2‐adrenoceptor–Gsα fusion protein

B. Kobilka, K. Wenzel-Seifert, R. Seifert, 1999 .

Different effects of Gsalpha splice variants on beta2-adrenoreceptor-mediated signaling. The beta2-adrenoreceptor coupled to the long splice variant of Gsalpha has properties of a constitutively active receptor.

B. Kobilka, K. Wenzel-Seifert, R. Seifert, 1998, The Journal of biological chemistry.

Distinct interaction of human and guinea pig histamine H2-receptor with guanidine-type agonists.

T. Bürckstümmer, K. Wenzel-Seifert, R. Seifert, 2001, Molecular pharmacology.

Systematic analysis of histamine and N-methylhistamine concentrations in organs from two common laboratory mouse strains: C57Bl/6 and Balb/c

R. Seifert, Anna-Sophie Zimmermann, D. Neumann, 2011, Inflammation Research.

cCMP and cUMP: emerging second messengers.

R. Seifert, 2015, Trends in biochemical sciences.

cAMP, cGMP, cCMP and cUMP concentrations across the tree of life: High cCMP and cUMP levels in astrocytes

R. Seifert, V. Kaever, H. Bähre, 2014, Neuroscience Letters.

Histamine increases cytosolic Ca2+ in HL-60 promyelocytes predominantly via H2 receptors with an unique agonist/antagonist profile and induces functional differentiation.

R. Seifert, A. Buschauer, A. Höer, 1992, Molecular pharmacology.

Studies with protein kinase C inhibitors presently available cannot elucidate the role of protein kinase C in the activation of NADPH oxidase.

R. Seifert, C. Schächtele, C. Schächtele, 1988, Biochemical and biophysical research communications.

Arachidonic Acid-Induced Activation of NADPH Oxidase in Membranes of Human Neutrophils and HL-60 Leukemic Cells is Regulated by Guanine Nucleotide-Binding Proteins and is Independent of Ca2+ and Protein Kinase C

G. Schultz, R. Seifert, C. Schächtele, 1988 .

Activation of protein kinase C by cis- and trans-octadecadienoic acids in intact human platelets and its potentiation by diacylglycerol.

G. Schultz, R. Seifert, C. Schächtele, 1987, Biochemical and biophysical research communications.

The H1 receptor agonist 2-(3-chlorophenyl)histamine activates Gi proteins in HL-60 cells through a mechanism that is independent of known histamine receptor subtypes.

G. Schultz, R. Seifert, S. Offermanns, 1994, Molecular pharmacology.

Interaction of fenoterol stereoisomers with β2-adrenoceptor-Gsα fusion proteins: antagonist and agonist competition binding

R. Seifert, M. Reinartz, I. Wainer, 2015, Naunyn-Schmiedeberg's Archives of Pharmacology.

Inactivation of Non-canonical Cyclic Nucleotides: Hydrolysis and Transport.

R. Seifert, E. Schneider, 2017, Handbook of experimental pharmacology.

Distinct Signalling Pathways of Murine Histamine H1- and H4-Receptors Expressed at Comparable Levels in HEK293 Cells

R. Seifert, D. Neumann, S. Beermann, 2014, PloS one.

Impairment of adenylyl cyclase 2 function and expression in hypoxanthine phosphoribosyltransferase-deficient rat B103 neuroblastoma cells as model for Lesch–Nyhan disease: BODIPY–forskolin as pharmacological tool

R. Seifert, J. V. D. Ohe, Liz Kinast, 2012, Naunyn-Schmiedeberg's Archives of Pharmacology.

Drugs for Treatment of Diabetes Mellitus

R. Seifert, 2019, Basic Knowledge of Pharmacology.

Differential modulation by N4, 2'-O-dibutyryl cytidine 3':5'-cyclic monophosphate of neutrophil activation.

R. Seifert, J. Ervens, 1991, Biochemical and biophysical research communications.

Evidence that inhibition of phorbol ester-induced superoxide anion formation by cyclosporin A in phagocytes is not mediated by direct inhibition of protein kinase C.

K. Wenzel-Seifert, R. Seifert, C. Schächtele, 1994, Biochemical pharmacology.

Faculty Opinions recommendation of K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions.

Roland Seifert, R. Seifert, 2013 .

High constitutive Akt2 activity in U937 promonocytes: effective reduction of Akt2 phosphorylation by the histamine H2-receptor and the β2-adrenergic receptor

R. Seifert, D. Neumann, K. Werner, 2015, Naunyn-Schmiedeberg's Archives of Pharmacology.

Adenylyl and Guanylyl Cyclase Assays

R. Seifert, W. Thompson, T. Stevens, 2005, Current protocols in pharmacology.

Critical role of N-terminal N-glycosylation for proper folding of the human formyl peptide receptor.

K. Wenzel-Seifert, R. Seifert, K. Wenzel‐Seifert, 2003, Biochemical and biophysical research communications.

Differential activation of Gi and Gs proteins by E- and I-type prostaglandins in membranes from the human erythroleukaemia cell line, HEL.

G. Schultz, R. Seifert, S. Offermanns, 1995, Biochimica et biophysica acta.

Flow cytometric analysis with a fluorescently labeled formyl peptide receptor ligand as a new method to study the pharmacological profile of the histamine H2 receptor

R. Seifert, A. Buschauer, D. Neumann, 2015, Naunyn-Schmiedeberg's Archives of Pharmacology.

cCMP and cUMP Across the Tree of Life: From cCMP and cUMP Generators to cCMP- and cUMP-Regulated Cell Functions.

R. Seifert, 2017, Handbook of experimental pharmacology.

Inhibition of NADPH Oxidase

G. Schultz, R. Seifert, 1991 .

R. Seifert, H. Liu, K. Wenzel‐Seifert, 2002, Biochemical pharmacology.

Fishing for elusive cCMP-degrading phosphodiesterases

R. Seifert, V. Kaever, E. Schneider, 2013, BMC Pharmacology and Toxicology.

Drugs for Treatment of Gout

R. Seifert, 2019, Basic Knowledge of Pharmacology.

How do basic secretagogues activate mast cells?

R. Seifert, 2015, Naunyn-Schmiedeberg's Archives of Pharmacology.

Direct and indirect receptor‐independent G‐protein activation by cationic‐amphiphilic substances. Studies with mast cells, HL‐60 human leukemic cells and purified G‐proteins

R. Seifert, J. F. Klinker, Astrid Hageluken, 1995, Experimental dermatology.

Histamine receptor-dependent and/or -independent activation of guanine nucleotide-binding proteins by histamine and 2-substituted histamine derivatives in human leukemia (HL-60) and human erythroleukemia (HEL) cells.

G. Schultz, R. Seifert, B. Nürnberg, 1995, Biochemical pharmacology.

Histamine H4-receptor expression in the brain?

R. Seifert, D. Neumann, E. Schneider, 2014, Naunyn-Schmiedeberg's Archives of Pharmacology.

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes

Stephen P. H. Alexander, C. Southan, D. Fabbro, 2021, British journal of pharmacology.

Drugs for Treatment of Schizophrenia

R. Seifert, 2019, Basic Knowledge of Pharmacology.

Human neutrophils and HL-60 cells do not possess α2-adrenoceptors

R. Seifert, I. Musgrave, 1994 .

Differential inhibition and potentiation of chemoattractant-induced superoxide formation in human neutrophils by the cell-permeant analogue of cyclic GMP, N2,2′-O-dibutyryl guanosine 3′:5′-cyclic monophosphate

G. Schultz, R. Seifert, J. Ervens, 1991, Naunyn-Schmiedeberg's Archives of Pharmacology.

Differential expression of cytosolic activation factors for NADPH oxidase in HL-60 leukemic cells.

G. Schultz, R. Seifert, P. Jungblut, 1989, Biochemical and biophysical research communications.

Inhalation and Injection Anesthetics

R. Seifert, 2019, Basic Knowledge of Pharmacology.

Physiological Roles of Mammalian Transmembrane Adenylyl Cyclase Isoforms.

C. Dessauer, R. Seifert, R. Ostrom, 2021, Physiological reviews.

Acylguanidines as bioisosteres of guanidines: NG-acylated imidazolylpropylguanidines, a new class of histamine H2 receptor agonists.

R. Seifert, M. Keller, Patrick Igel, 2008, Journal of medicinal chemistry.

Synthesis of a hydrolytically stable, fluorescent-labeled ATP analog as a tool for probing adenylyl cyclases.

C. Müller, R. Seifert, A. Link, 2010, Bioorganic & medicinal chemistry letters.

Activation by beta-carbolines of G-proteins in HL-60 membranes and the bovine retinal G-protein transducin in a receptor-independent manner.

R. Seifert, H. Rommelspacher, H. Damm, 1997, Biochemical pharmacology.

2,4-Diaminopyrimidines as histamine H4 receptor ligands--Scaffold optimization and pharmacological characterization.

Gisbert Schneider, Ewgenij Proschak, Roland Seifert, 2009, Bioorganic & medicinal chemistry.

Generation of a homology model of the human histamine H3 receptor for ligand docking and pharmacophore-based screening

René Meier, Thierry Langer, Hans-Dieter Höltje, 2007, J. Comput. Aided Mol. Des..

The Yellow Color of Silver-Containing Zeolite A.

G. Calzaferri, R. Seifert, A. Kunzmann, 1998, Angewandte Chemie.

Distinct interactions of 2'- and 3'-O-(N-methyl)anthraniloyl-isomers of ATP and GTP with the adenylyl cyclase toxin of Bacillus anthracis, edema factor.

R. Seifert, Wei-Jen Tang, G. Lushington, 2009, Biochemical pharmacology.

Characterization of Mouse Heart Adenylyl Cyclase

R. Seifert, B. König, A. Gille, 2009, Journal of Pharmacology and Experimental Therapeutics.

Molecular Analysis of the Interaction of Anthrax Adenylyl Cyclase Toxin, Edema Factor, with 2′(3′)-O-(N-(methyl)anthraniloyl)-Substituted Purine and Pyrimidine Nucleotides

R. Seifert, Wei-Jen Tang, Yuequan Shen, 2009, Molecular Pharmacology.

Molecular Analysis of the Interaction of Bordetella pertussis Adenylyl Cyclase with Fluorescent Nucleotides

R. Seifert, Wei-Jen Tang, P. Steindel, 2007, Molecular Pharmacology.

Broad Specificity of Mammalian Adenylyl Cyclase for Interaction with 2′,3′-Substituted Purine- and Pyrimidine Nucleotide Inhibitors

Roland Seifert, Andreas Gille, S. Sprang, 2006, Molecular Pharmacology.

Structural Basis for the Inhibition of Mammalian Membrane Adenylyl Cyclase by 2 ′(3′)-O-(N-Methylanthraniloyl)-guanosine 5 ′-Triphosphate*

Roland Seifert, Andreas Gille, S. Sprang, 2005, Journal of Biological Chemistry.

Structure-activity relationships of histamine H2 receptor ligands.

R. Seifert, A. Buschauer, S. Dove, 2004, Mini reviews in medicinal chemistry.

International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases

C. Dessauer, R. Seifert, M. Conti, 2017, Pharmacological Reviews.

From canonical to non-canonical cyclic nucleotides as second messengers: pharmacological implications.

R. Seifert, H. Bähre, E. Schneider, 2015, Pharmacology & therapeutics.

N4-monobutyryl-cCMP activates PKA RIα and PKA RIIα more potently and with higher efficacy than PKG Iα in vitro but not in vivo

R. Seifert, S. Dove, F. Schwede, 2014, Naunyn-Schmiedeberg's Archives of Pharmacology.

QUANTUM-SIZED SILVER SULFIDE CLUSTERS IN ZEOLITE A

G. Calzaferri, R. Seifert, D. Brühwiler, 1999 .

Incomplete activation of human eosinophils via the histamine H4-receptor: evidence for ligand-specific receptor conformations.

R. Seifert, A. Buschauer, D. Neumann, 2012, Biochemical pharmacology.

An extracytoplasmic protein and a moonlighting enzyme modulate synthesis of c-di-AMP in Listeria monocytogenes.

R. Seifert, R. Ficner, J. Rosenberg, 2020, Environmental microbiology.

Guideline (S2k) on acute therapy and management of anaphylaxis: 2021 update

H. Sitter, L. Klimek, O. Pfaar, 2021, Allergo Journal International.

Guideline for acute therapy and management of anaphylaxis

H. Sitter, B. Niggemann, L. Klimek, 2014, Allergo Journal International.

R. Seifert, H. Liu, K. Wenzel‐Seifert, 2002 .

Chemoattractant Receptor-G-Protein Coupling

R. Seifert, K. Wenzel‐Seifert, 2001 .

Functional selectivity of G-protein-coupled receptors: from recombinant systems to native human cells.

R. Seifert, 2013, Biochemical pharmacology.

Effects of guanine, inosine, and xanthine nucleotides on beta(2)-adrenergic receptor/G(s) interactions: evidence for multiple receptor conformations.

R Seifert, B. Kobilka, R. Seifert, 1999, Molecular pharmacology.

G-protein alpha-subunits in cytosolic and membranous fractions of human neutrophils.

G. Schultz, R. Seifert, M. Bigalke, 1989, Molecular and cellular endocrinology.

The Pseudomonas aeruginosa ExoY phenotype of high-copy-number recombinants is not detectable in natural isolates

J. Klockgether, R. Seifert, B. Tümmler, 2018, Open Biology.

ExoY from Pseudomonas aeruginosa is a nucleotidyl cyclase with preference for cGMP and cUMP formation.

R. Seifert, D. Ladant, V. Kaever, 2014, Biochemical and biophysical research communications.

Hydrolysis of the non-canonical cyclic nucleotide cUMP by PDE9A: kinetics and binding mode

R. Seifert, V. Kaever, E. Schneider, 2018, Naunyn-Schmiedeberg's Archives of Pharmacology.

cCMP and cUMP occur in vivo.

R. Seifert, B. Tümmler, V. Kaever, 2015, Biochemical and biophysical research communications.

Heterogeneity of Pulmonary Endothelial Cyclic Nucleotide Response to Pseudomonas aeruginosa Infection

R. Seifert, D. Frank, T. Stevens, 2015, American journal of physiology. Lung cellular and molecular physiology.

cNMP-AMs mimic and dissect bacterial nucleotidyl cyclase toxin effects.

R. Seifert, E. Kostenis, H. Rehmann, 2014, Biochemical and biophysical research communications.

cCMP is a substrate for MRP5

R. Seifert, F. Russel, V. Kaever, 2014, Naunyn-Schmiedeberg's Archives of Pharmacology.

Soluble adenylyl cyclase accounts for high basal cCMP and cUMP concentrations in HEK293 and B103 cells.

R. Seifert, K. Danker, V. Kaever, 2014, Biochemical and biophysical research communications.

Nucleotidyl cyclase activity of soluble guanylyl cyclase in intact cells.

J. Stasch, R. Seifert, K. Danker, 2014, Biochemical and biophysical research communications.

The Receptor-Bound Guanylyl Cyclase DAF-11 Is the Mediator of Hydrogen Peroxide-Induced Cgmp Increase in Caenorhabditis elegans

R. Seifert, L. Timmons, V. Kaever, 2013, PloS one.

Interaction of the retinal G-protein transducin with uracil nucleotides.

R. Seifert, J. F. Klinker, 1999, Biochemical and biophysical research communications.

cGAS-like receptors sense RNA and control 3′2′-cGAMP signalling in Drosophila

P. J. Kranzusch, R. Seifert, J. Imler, 2021, Nature.

Convenient Preparation of Close-Packed Monograin Layers of Pure Zeolite A Microcrystals.

G. Calzaferri, R. Seifert, P. Lainé, 1997 .

G-protein-coupled receptors in HL-60 human leukemia cells.

R. Seifert, J. F. Klinker, K. Wenzel‐Seifert, 1996, General pharmacology.

Purine and pyrimidine nucleotides potentiate activation of NADPH oxidase and degranulation by chemotactic peptides and induce aggregation of human neutrophils via G proteins.

G. Schultz, R. Seifert, F. Eckstein, 1989, European journal of biochemistry.

Analysis of Histamine Receptor Knockout Mice in Models of Inflammation

Roland Seifert, Detlef Neumann, R. Seifert, 2014, The Journal of Pharmacology and Experimental Therapeutics.

Characterization of histamine H2-receptors in human neutrophils with a series of guanidine analogues of impromidine

R. Seifert, A. Buschauer, R. Burde, 1990, Naunyn-Schmiedeberg's Archives of Pharmacology.

Co-expression of the beta2-adrenoceptor and dopamine D1-receptor with Gsalpha proteins in Sf9 insect cells: limitations in comparison with fusion proteins.

R. Seifert, A. Gille, 2003, Biochimica et biophysica acta.

Distinct interactions of Gsα-long, Gsα-short, and Gαolf with GTP, ITP, and XTP

Hui-yu Liu, R. Seifert, 2002 .

Histamine induces chemotaxis and phagocytosis in murine bone marrow-derived macrophages and RAW 264.7 macrophage-like cells via histamine H4-receptor

R. Seifert, A. Klos, D. Neumann, 2013, Inflammation Research.

Some taste substances are direct activators of G-proteins.

G. Schultz, R. Seifert, B. Nürnberg, 1994, The Biochemical journal.

Extracellular vesicles: another compartment for the second messenger, cyclic adenosine monophosphate.

R. Seifert, V. Kaever, Sarah L Sayner, 2019, American journal of physiology. Lung cellular and molecular physiology.

Nucleotidyl Cyclase Activity of Particulate Guanylyl Cyclase A: Comparison with Particulate Guanylyl Cyclases E and F, Soluble Guanylyl Cyclase and Bacterial Adenylyl Cyclases Cyaa and Edema Factor

R. Seifert, Wei-Jen Tang, K. Koch, 2013, PloS one.

Inhibitors of membranous adenylyl cyclases.

Roland Seifert, Andreas Gille, Gerald H Lushington, 2012, Trends in pharmacological sciences.

A fluorimetric assay for real-time monitoring of adenylyl cyclase activity based on terbium norfloxacin.

Roland Seifert, Yuequan Shen, Michael Schäferling, 2008, Analytical biochemistry.

The histamine H4-receptor and the central and peripheral nervous system: A critical analysis of the literature

R. Seifert, E. Schneider, 2016, Neuropharmacology.

Modulation of behavior by the histaminergic system: Lessons from HDC-, H3R- and H4R-deficient mice

R. Seifert, D. Neumann, E. Schneider, 2014, Neuroscience & Biobehavioral Reviews.

Modulation of behavior by the histaminergic system: Lessons from H1R-and H2R-deficient mice

R. Seifert, D. Neumann, E. Schneider, 2014, Neuroscience & Biobehavioral Reviews.

Structure/Activity Relationships of (M)ANT- and TNP-Nucleotides for Inhibition of Rat Soluble Guanylyl Cyclase α1β1

J. Stasch, R. Seifert, K. Danker, 2014, Molecular Pharmacology.

Altered membrane NTPase activity in Lesch–Nyhan disease fibroblasts: comparison with HPRT knockout mice and HPRT‐deficient cell lines

R. Seifert, H. Jinnah, W. Nyhan, 2005, Journal of neurochemistry.

Neurotransmitter and their metabolite concentrations in different areas of the HPRT knockout mouse brain

R. Seifert, V. Kaever, S. Tschirner, 2016, Journal of the Neurological Sciences.

Activation of NADPH oxidase by purine and pyrimidine nucleotides involves G proteins and is potentiated by chemotactic peptides.

G. Schultz, R. Seifert, R. Burde, 1989, The Biochemical journal.

Serotonergic System

R. Seifert, 2019, Basic Knowledge of Pharmacology.

The effect of pH on beta(2) adrenoceptor function. Evidence for protonation-dependent activation.

P Ghanouni, R Seifert, S. Rasmussen, 2000, The Journal of biological chemistry.

Pharmacological Profile of Histaprodifens at Four Recombinant Histamine H1 Receptor Species Isoforms

Hans-Joachim Wittmann, A. Strasser, R. Seifert, 2008, Journal of Pharmacology and Experimental Therapeutics.

Influence of the N-terminus and the E2-loop onto the binding kinetics of the antagonist mepyramine and the partial agonist phenoprodifen to H(1)R.

Hans-Joachim Wittmann, A. Strasser, R. Seifert, 2011, Biochemical pharmacology.

Bibliometric development of Naunyn–Schmiedeberg’s Archives of Pharmacology

R. Seifert, Leah B. Dats, Florentin von Haugwitz, 2022, Naunyn-Schmiedeberg's archives of pharmacology.

Lipophilic beta-adrenoceptor antagonists and local anesthetics are effective direct activators of G-proteins.

R. Seifert, B. Nürnberg, W. Schunack, 1994, Biochemical pharmacology.

Botulinum C2 toxin ADP-ribosylates actin and enhances O2- production and secretion but inhibits migration of activated human neutrophils.

R. Seifert, J. Norgauer, K. Aktories, 1988, The Journal of clinical investigation.

Morphine and muscle relaxants are receptor-independent G-protein activators and cromolyn is an inhibitor of stimulated G-protein activity

R. Seifert, J. F. Klinker, 1997, Inflammation Research.

Therapeutic Efficacy of a H4 Receptor Antagonist in Humans: A Milestone in Histamine Research

R. Seifert, 2014, The Journal of Pharmacology and Experimental Therapeutics.

Histamine H1, H3 and H4 receptors are involved in pruritus

H. Stark, R. Seifert, M. Kietzmann, 2011, Neuroscience.

Octopamine drives honeybee thermogenesis

R. Seifert, H. Bähre, O. Scherf-Clavel, 2021, bioRxiv.

The role of nucleoside-diphosphate kinase reactions in G protein activation of NADPH oxidase by guanine and adenine nucleotides.

T. Wieland, G. Schultz, K. Jakobs, 1988, European journal of biochemistry.

Reversible activation of NADPH oxidase in membranes of HL-60 human leukemic cells.

G. Schultz, R. Seifert, 1987, Biochemical and biophysical research communications.

Mathematical analysis of the sodium sensitivity of the human histamine H3 receptor

Hans-Joachim Wittmann, A. Strasser, R. Seifert, 2014, In Silico Pharmacology.

Impact of the DRY Motif and the Missing “Ionic Lock” on Constitutive Activity and G-Protein Coupling of the Human Histamine H4 Receptor

A. Strasser, R. Seifert, E. Schneider, 2010, Journal of Pharmacology and Experimental Therapeutics.

Constitutive activity of G-protein-coupled receptors: cause of disease and common property of wild-type receptors

R. Seifert, K. Wenzel‐Seifert, 2002, Naunyn-Schmiedeberg's Archives of Pharmacology.

Structural Instability of a Constitutively Active G Protein-coupled Receptor

Brian K. Kobilka, Harel Weinstein, Roland Seifert, 1997, The Journal of Biological Chemistry.

The human formyl peptide receptor as model system for constitutively active G-protein-coupled receptors.

R. Seifert, K. Wenzel‐Seifert, 2003, Life sciences.

Sf9 cells: a versatile model system to investigate the pharmacological properties of G protein-coupled receptors.

Roland Seifert, R. Seifert, E. Schneider, 2010, Pharmacology & therapeutics.

Differential Inhibition of Various Adenylyl Cyclase Isoforms and Soluble Guanylyl Cyclase by 2′,3′-O-(2,4,6-Trinitrophenyl)-Substituted Nucleoside 5′-Triphosphates

S. Sprang, R. Seifert, T. Mou, 2009, Journal of Pharmacology and Experimental Therapeutics.

Interactions of recombinant human histamine H1, H2, H3, and H4 receptors with 34 antidepressants and antipsychotics

A. Strasser, R. Seifert, S. Dove, 2011, Naunyn-Schmiedeberg's Archives of Pharmacology.

Putative Nucleotide-Based Second Messengers in the Archaeal Model Organisms Haloferax volcanii and Sulfolobus acidocaldarius

R. Seifert, S. Albers, H. Bähre, 2021, Frontiers in Microbiology.

Analysis of the histamine H2-receptor in human monocytes.

R. Seifert, D. Neumann, K. Werner, 2014, Biochemical pharmacology.

cCMP and cUMP in Apoptosis: Concepts and Methods.

R. Seifert, Sabine Wolter, F. Dittmar, 2017, Handbook of experimental pharmacology.

Regulation of apoptosis by cyclic nucleotides in human erythroleukemia (HEL) cells and human myelogenous leukemia (K-562) cells.

R. Seifert, Sabine Wolter, F. Dittmar, 2016, Biochemical pharmacology.

cUMP hydrolysis by PDE3B

R. Seifert, V. Kaever, E. Schneider, 2017, Naunyn-Schmiedeberg's Archives of Pharmacology.

Temporal and organ-specific detection of cNMPs including cUMP in the zebrafish.

R. Seifert, V. Kaever, S. Tschirner, 2015, Biochemical and biophysical research communications.

cCMP causes caspase-dependent apoptosis in mouse lymphoma cell lines.

R. Seifert, Christina Kloth, M. Golombek, 2015, Biochemical pharmacology.

N4-monobutyryl-cCMP activates PKA RIα and PKA RIIα more potently and with higher efficacy than PKG Iα in vitro but not in vivo

R. Seifert, S. Dove, F. Schwede, 2014, Naunyn-Schmiedeberg's Archives of Pharmacology.

cCMP is a substrate for MRP5

R. Seifert, F. Russel, V. Kaever, 2014, Naunyn-Schmiedeberg's Archives of Pharmacology.

Differential activation of cAMP- and cGMP-dependent protein kinases by cyclic purine and pyrimidine nucleotides.

R. Seifert, M. Golombek, Sabine Wolter, 2011, Biochemical and biophysical research communications.

Impact of divalent metal ions on regulation of adenylyl cyclase isoforms by forskolin analogs.

R. Seifert, T. Mou, M. Erdorf, 2011, Biochemical pharmacology.

Cyclic CMP and cyclic UMP: new (old) second messengers

R. Seifert, A. Pich, V. Kaever, 2011, BMC Pharmacology.

Xanthine nucleotide-specific G-protein α-subunits: a novel approach for the analysis of G-protein-mediated signal transduction

R. Seifert, A. Gille, 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

History of pharmacology:2 - The Institute of Pharmacology of the University of Strasbourg: genealogy and biographies

R. Seifert, A. Philippu, 2022, Naunyn-Schmiedeberg's archives of pharmacology.

Quantitative Analysis of Formyl Peptide Receptor Coupling to Giα1, Giα2, and Giα3 *

Hui-yu Liu, R. Seifert, J. Arthur, 1999, The Journal of Biological Chemistry.

Histamine and Histamine Receptors in Health and Disease

R. Seifert, Y. Hattori, 2017 .

Altered histamine neurotransmission in HPRT-deficient mice

R. Seifert, V. Kaever, S. Tschirner, 2015, Neuroscience Letters.

Cross‐linking of CD18 in human neutrophils induces an increase of intracellular free Ca2+, exocytosis of azurophilic granules, quantitative up‐regulation of CD18, shedding of L‐selectin, and actin polymerization

K. Ley, P. Gaehtgens, B. Walzog, 1994, Journal of leukocyte biology.

Commercially available antibodies against human and murine histamine H4-receptor lack specificity

R. Seifert, D. Neumann, S. Beermann, 2011, Naunyn-Schmiedeberg's Archives of Pharmacology.

Functional reconstitution of the human chemokine receptor CXCR4 with Gi/Go-proteins in Sf9 insect cells

R. Seifert, Sandra C. Vigil-Cruz, D. Papa, 2008, Naunyn-Schmiedeberg's Archives of Pharmacology.

Nucleoside diphosphate kinase activity in soluble transducin preparations biochemical properties and possible role of transducin-beta as phosphorylated enzyme intermediate.

R. Seifert, J. F. Klinker, 1999, European journal of biochemistry.

Histamine receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

H. Haas, J. Schwartz, R. Thurmond, 2019, IUPHAR/BPS Guide to Pharmacology CITE.

Stimulation of histamine H2- (and H1)-receptors activates Ca2+ influx in all-atrans-retinoic acid-differentiated HL-60 cells independently of phospholipase C or adenylyl cyclase

R. Seifert, R. Burde, 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

The human histamine H2‐receptor couples more efficiently to Sf9 insect cell Gs‐proteins than to insect cell Gq‐proteins: limitations of Sf9 cells for the analysis of receptor/Gq‐protein coupling

T. Bürckstümmer, R. Seifert, K. Wenzel‐Seifert, 2002, Journal of neurochemistry.

GPCR–Gα fusion proteins: molecular analysis of receptor–G-protein coupling

B. Kobilka, R. Seifert, K. Wenzel‐Seifert, 1999 .

Membranous adenylyl cyclase 1 activation is regulated by oxidation of N- and C-terminal methionine residues in calmodulin.

R. Seifert, M. Fedorova, S. Dove, 2015, Biochemical pharmacology.

Different Roles of N-Terminal and C-Terminal Domains in Calmodulin for Activation of Bacillus anthracis Edema Factor

R. Seifert, Wei-Jen Tang, S. Dove, 2015, Toxins.

Molecular analysis of beta(2)-adrenoceptor coupling to G(s)-, G(i)-, and G(q)-proteins.

R. Seifert, Roland Seifert, K. Wenzel‐Seifert, 2000, Molecular pharmacology.

Molecular Analysis of b 2-Adrenoceptor Coupling to Gs-, Gi-, and Gq-Proteins

R. Seifert, KATHARINA WENZEL-SEIFERT, ROLAND SEIFERT, 2000 .

Structural Requirements for Inverse Agonism and Neutral Antagonism of Indole-, Benzimidazole-, and Thienopyrrole-Derived Histamine H4 Receptor Ligands

Roland Seifert, Andrea Strasser, R. Thurmond, 2010, Journal of Pharmacology and Experimental Therapeutics.

The class III antiarrhythmic drug amiodarone directly activates pertussis toxin-sensitive G proteins.

R. Seifert, B. Nürnberg, W. Schunack, 1995, Molecular pharmacology.

Receptor-specific functional efficacies of alkyl imidazoles as dual histamine H3/H4 receptor ligands.

H. Stark, R. Seifert, K. Sander, 2011, European journal of pharmacology.

Comparison of the pharmacological properties of human and rat histamine H(3)-receptors.

A. Strasser, R. Seifert, D. Schnell, 2010, Biochemical pharmacology.

Properties of Arg389-β 1 -Adrenoceptor-G sα Fusion Proteins: Comparison with Gly389-β 1 -Adrenoceptor-G sα Fusion Proteins

R. Seifert, K. Wenzel‐Seifert, 2003 .

Pharmacological characterization of adenylyl cyclase isoforms in rabbit kidney membranes

R. Seifert, M. Erdorf, 2011, Naunyn-Schmiedeberg's Archives of Pharmacology.

Problems associated with the use of the term “antibiotics”

R. Seifert, Bastian Schirmer, 2021, Naunyn-Schmiedeberg's Archives of Pharmacology.

Structure-bias relationships for fenoterol stereoisomers in six molecular and cellular assays at the β2-adrenoceptor

R. Seifert, M. Reinartz, T. Ozawa, 2014, Naunyn-Schmiedeberg's Archives of Pharmacology.

Functional Selectivity of GPCR Ligand Stereoisomers: New Pharmacological Opportunities

R. Seifert, S. Dove, 2009, Molecular Pharmacology.

Differential activation of dibutyryl cAMP-differentiated HL-60 human leukemia cells by chemoattractants.

R. Seifert, S. Offermanns, I. Schwaner, 1994, Biochemical pharmacology.

Interaction of fenoterol stereoisomers with β2-adrenoceptor-Gsα fusion proteins: antagonist and agonist competition binding

R. Seifert, M. Reinartz, I. Wainer, 2015, Naunyn-Schmiedeberg's Archives of Pharmacology.

Distinct Interactions of Human β1- and β2-Adrenoceptors with Isoproterenol, Epinephrine, Norepinephrine, and Dopamine

R. Seifert, Nina Weitl, 2008, Journal of Pharmacology and Experimental Therapeutics.

Lipopeptides activate Gi-proteins in dibutyryl cyclic AMP-differentiated HL-60 cells.

R. Seifert, S. Offermanns, A. Höer, 1993, The Biochemical journal.

Incomplete functional differentiation of HL-60 leukemic cells by synthetic lipopeptides. Partial inhibition by pertussis toxin of enhanced superoxide formation.

D. Huhn, W. Bessler, R. Seifert, 1992, European journal of biochemistry.

Nucleotide-, chemotactic peptide- and phorbol ester-induced exocytosis in HL-60 leukemic cells.

R. Seifert, K. Wenzel‐Seifert, 1990, Immunobiology.

IN MEMBRANES OF HL-60 HUMAN LEUKEMIC CELLS

R. Seifert, G. Schultz, 1987 .

History of pharmacology: 1—the Department of Pharmacology of the University of Tartu (Dorpat): genealogy and biographies

R. Seifert, A. Philippu, 2022, Naunyn-Schmiedeberg's archives of pharmacology.

Reflections on the 150th anniversary of Naunyn–Schmiedeberg’s Archives of Pharmacology: past, challenges, and future

R. Seifert, Y. Hattori, 2022, Naunyn-Schmiedeberg's archives of pharmacology.

A GGDEF domain serves as a spatial on-switch for a phosphodiesterase by direct interaction with a polar landmark protein

Georg K. A. Hochberg, K. Thormann, R. Seifert, 2021, bioRxiv.

Contribution of Binding Enthalpy and Entropy to Affinity of Antagonist and Agonist Binding at Human and Guinea Pig Histamine H1-Receptor

Hans-Joachim Wittmann, A. Strasser, R. Seifert, 2009, Molecular Pharmacology.

Microsoft Word-91201841-file00

R. Seifert, N. Kowalsman, Nataliya Gorinski, 2012 .

Computational and Experimental Analysis of the Transmembrane Domain 4/5 Dimerization Interface of the Serotonin 5-HT1A Receptor □S

M. Niv, R. Seifert, N. Kowalsman, 2012 .

Vidarabine is neither a potent nor a selective AC5 inhibitor.

R. Seifert, 2014, Biochemical pharmacology.

Binding Kinetics and Pathways of Ligands to GPCRs.

Hans-Joachim Wittmann, A. Strasser, R. Seifert, 2017, Trends in pharmacological sciences.

cUMP hydrolysis by PDE3B

R. Seifert, V. Kaever, E. Schneider, 2018, Naunyn-Schmiedeberg's Archives of Pharmacology.

Cytidylyl and uridylyl cyclase activity of bacillus anthracis edema factor and Bordetella pertussis CyaA.

R. Seifert, J. Schlossmann, Wei-Jen Tang, 2010, Biochemistry.

Genetic Deficiency of the Histamine H4-Receptor Reduces Experimental Colorectal Carcinogenesis in Mice

R. Seifert, A. Bleich, D. Jonigk, 2020, Cancers.

Different effects of Gsalpha splice variants on beta2-adrenoreceptor-mediated signaling. The Beta2-adrenoreceptor coupled to the long splice variant of Gsalpha has properties of a constitutively active receptor.

B. Kobilka, R. Seifert, U. Gether, 1998, The Journal of biological chemistry.

Activation of soluble guanylyl cyclase signalling with cinaciguat improves impaired kidney function in diabetic mice

R. Seifert, J. Schlossmann, Manuela Harloff, 2021, British journal of pharmacology.

Hrs-2 is an ATPase implicated in calcium-regulated secretion

R. Scheller, R. Seifert, Yu A. Chen, 1997, Nature.

Selectivity of pharmacological tools: implications for use in cell physiology. A review in the theme: Cell signaling: proteins, pathways and mechanisms.

R. Seifert, M. Michel, 2015, American journal of physiology. Cell physiology.

Reconstitution of beta2-adrenoceptor-GTP-binding-protein interaction in Sf9 cells--high coupling efficiency in a beta2-adrenoceptor-G(s alpha) fusion protein.

B. Kobilka, R. Seifert, T. Lee, 1998, European Journal of Biochemistry.

Structure-Activity Relationships of Histamine H_2 Receptor Ligands,

R. Seifert, A. Buschauer, S. Dove, 2004 .

N(alpha)-imidazolylalkyl and pyridylalkyl derivatives of histaprodifen: synthesis and in vitro evaluation of highly potent histamine H(1)-receptor agonists.

R. Seifert, H. Pertz, W. Schunack, 2003, Journal of medicinal chemistry.

Functional differences between full and partial agonists: evidence for ligand-specific receptor conformations.

B. Kobilka, R. Seifert, U. Gether, 2001, The Journal of pharmacology and experimental therapeutics.

Activation of protein kinase C by cis- and trans-fatty acids and its potentiation by diacylglycerol.

G. Schultz, R. Seifert, C. Schächtele, 1988, Biochemical and biophysical research communications.

How Naunyn-Schmiedeberg’s Archives of Pharmacology deals with fraudulent papers from paper mills

R. Seifert, 2021, Naunyn-Schmiedeberg's Archives of Pharmacology.

How criminal science publishing gangs damage the genesis of knowledge and technology—a call to action to restore trust

B. Sabel, R. Seifert, 2021, Naunyn-Schmiedeberg's Archives of Pharmacology.

Drugs for Treatment of Osteoporosis

R. Seifert, 2019, Basic Knowledge of Pharmacology.

Histamine induces chemotaxis and phagocytosis in murine bone marrow-derived macrophages and RAW 264.7 macrophage-like cells via histamine H4-receptor

R. Seifert, A. Klos, D. Neumann, 2014, Inflammation Research.

A conformational transition in the adenylyl cyclase catalytic site yields different binding modes for ribosyl-modified and unmodified nucleotide inhibitors.

R. Seifert, G. Lushington, Qi-Yuan Zhang, 2007, Bioorganic & medicinal chemistry.

Fishing for elusive cCMP-degrading phosphodiesterases

R. Seifert, V. Kaever, E. Schneider, 2013, BMC Pharmacology and Toxicology.

A simple mechanistic terminology of psychoactive drugs: a proposal

R. Seifert, Bastian Schirmer, 2020, Naunyn-Schmiedeberg's Archives of Pharmacology.

Is cIMP a second messenger with functions opposite to those of cGMP?

R. Seifert, 2014, Naunyn-Schmiedeberg's Archives of Pharmacology.

cCMP, cUMP, cTMP, cIMP and cXMP as possible second messengers: Development of a hypothesis based on studies with soluble guanylyl cyclase α1β1

R. Seifert, K. Beste, 2013, Biological chemistry.

Enzymes of the AKR1B and AKR1C subfamilies and uterine diseases

R. Seifert, W. Ni, Yi Jin, 2012 .

Differential Inhibition of Adenylyl Cyclase Isoforms and Soluble Guanylyl Cyclase by Purine and Pyrimidine Nucleotides*

R. Seifert, T. Mou, G. Lushington, 2004, Journal of Biological Chemistry.

Tritium‐Labeled N1‐[3‐(1H‐imidazol‐4‐yl)propyl]‐N2‐propionylguanidine ([3H]UR‐PI294), a High‐Affinity Histamine H3 and H4 Receptor Radioligand

R. Seifert, Patrick Igel, A. Buschauer, 2009, ChemMedChem.

From bedside to bench—meeting report of the 7th International Conference on cGMP “cGMP: generators, effectors and therapeutic implications” in Trier, Germany, from June 19th to 21st 2015

R. Seifert, A. Friebe, P. Sandner, 2015, Naunyn-Schmiedeberg's Archives of Pharmacology.

Structure-activity relationships for the interactions of 2'- and 3'-(O)-(N-methyl)anthraniloyl-substituted purine and pyrimidine nucleotides with mammalian adenylyl cyclases.

S. Sprang, R. Seifert, Cibele S. Pinto, 2011, Biochemical pharmacology.

Structural Basis for the High-Affinity Inhibition of Mammalian Membranous Adenylyl Cyclase by 2′,3′-O-(N-Methylanthraniloyl)-Inosine 5′-Triphosphate

S. Sprang, A. Dixit, R. Seifert, 2011, Molecular Pharmacology.

2′(3′)-O-(N-Methylanthraniloyl)-substituted GTP Analogs: A Novel Class of Potent Competitive Adenylyl Cyclase Inhibitors*

R. Seifert, A. Gille, 2003, The Journal of Biological Chemistry.

Adenylyl cyclase regulation in heart failure due to myocardial infarction in rats

R. Seifert, Barbara E. Albrecht-Küpper, Jörg H. Bräunig, 2014, Naunyn-Schmiedeberg's Archives of Pharmacology.

Bacillus anthracis Edema Factor Substrate Specificity: Evidence for New Modes of Action

R. Seifert, S. Dove, Martin Göttle, 2012, Toxins.

Does Vidarabine Mediate Cardioprotection via Inhibition of AC5?

R. Seifert, 2016, The Journal of Pharmacology and Experimental Therapeutics.

Structure / Activity Relationships of ( M ) ANT-and TNP-Nucleotides for Inhibition of Rat Soluble Guanylyl Cyclase a 1 b 1

J. Stasch, R. Seifert, K. Danker, 2014 .

Bis-Halogen-Anthraniloyl-Substituted Nucleoside 5′-Triphosphates as Potent and Selective Inhibitors of Bordetella pertussis Adenylyl Cyclase Toxin

R. Seifert, Wei-Jen Tang, Yuequan Shen, 2011, Journal of Pharmacology and Experimental Therapeutics.

The C1 homodimer of adenylyl cyclase binds nucleotides with high affinity but possesses exceedingly low catalytic activity

R. Seifert, Cibele S. Pinto, T. Mou, 2009, Neuroscience Letters.

MANT-substituted guanine nucleotides: a novel class of potent adenylyl cyclase inhibitors.

R. Seifert, A. Gille, 2003, Life sciences.

Drugs for the Treatment of Malignant Tumor Diseases

R. Seifert, 2019, Basic Knowledge of Pharmacology.

Mouse Colonic Epithelial Cells Functionally Express the Histamine H4 Receptor

R. Seifert, D. Neumann, L. Lindemann, 2020, The Journal of Pharmacology and Experimental Therapeutics.

Molecular determinants for the high constitutive activity of the human histamine H4 receptor: functional studies on orthologues and mutants

A. Strasser, R. Seifert, A. Buschauer, 2015, British journal of pharmacology.

Luciferase Reporter Gene Assay on Human, Murine and Rat Histamine H4 Receptor Orthologs: Correlations and Discrepancies between Distal and Proximal Readouts

H. Stark, R. Seifert, A. Buschauer, 2013, PloS one.

The dual H3/4R antagonist thioperamide does not fully mimic the effects of the ‘standard’ H4R antagonist JNJ 7777120 in experimental murine asthma

R. Seifert, D. Neumann, S. Glage, 2013, Naunyn-Schmiedeberg's Archives of Pharmacology.

Problems associated with the use of commercial and non-commercial antibodies against the histamine H4 receptor

R. Seifert, D. Männel, D. Jonigk, 2012, Naunyn-Schmiedeberg's Archives of Pharmacology.

Paradoxical Stimulatory Effects of the “Standard” Histamine H4-Receptor Antagonist JNJ7777120: the H4 Receptor Joins the Club of 7 Transmembrane Domain Receptors Exhibiting Functional Selectivity

A. Strasser, R. Seifert, A. Buschauer, 2011, Molecular Pharmacology.

Interactions of Histamine H1-Receptor Agonists and Antagonists with the Human Histamine H4-Receptor

A. Strasser, R. Seifert, D. Neumann, 2009, Molecular Pharmacology.

[Rationalized lithium adjustment by load-test (author's transl)].

R. Seifert, C. Junge, H. Bremkamp, 1975, Psychopharmacologia.

Identification of small molecules that interfere with c-di-GMP signaling and induce dispersal of Pseudomonas aeruginosa biofilms

R. Seifert, J. Berthelsen, T. Tolker-Nielsen, 2021, npj Biofilms and Microbiomes.

A door opener for future research: agonist-induced β3-adrenoceptor desensitization in HEK cells but not CHO cells

R. Seifert, 2013, Naunyn-Schmiedeberg's Archives of Pharmacology.

Modulation of GPCRs by monovalent cations and anions

Hans-Joachim Wittmann, A. Strasser, R. Seifert, 2015, Naunyn-Schmiedeberg's Archives of Pharmacology.

Pharmacological Characterization of Human Histamine Receptors and Histamine Receptor Mutants in the Sf9 Cell Expression System

R. Seifert, E. Schneider, 2017, Handbook of experimental pharmacology.

Naunyn-Schmiedeberg’s Archives of Pharmacology under new editorship: change and continuity

R. Seifert, 2016, Naunyn-Schmiedeberg's Archives of Pharmacology.

Sodium binding to hH3R and hH4R — a molecular modeling study

Hans-Joachim Wittmann, A. Strasser, R. Seifert, 2014, Journal of Molecular Modeling.

Role of the second and third extracellular loops of the histamine H4 receptor in receptor activation

A. Strasser, R. Seifert, A. Buschauer, 2011, Naunyn-Schmiedeberg's Archives of Pharmacology.

High constitutive activity and a G-protein-independent high-affinity state of the human histamine H(4)-receptor.

Roland Seifert, R. Seifert, E. Schneider, 2009, Biochemistry.

The prostacyclin analogues, cicaprost and iloprost, increase cytosolic Ca2+ concentration in the human erythroleukemia cell line, HEL, via pertussis toxin-insensitive G-proteins.

G. Schultz, R. Seifert, I. Schwaner, 1992, Eicosanoids.

GDP Affinity and Order State of the Catalytic Site Are Critical for Function of Xanthine Nucleotide-selective GαsProteins*

R. Seifert, A. Gille, M. Doughty, 2003, The Journal of Biological Chemistry.

Distinct Interactions of GTP, UTP, and CTP with GsProteins*

S. Sprang, Hui-yu Liu, R. Seifert, 2002, The Journal of Biological Chemistry.

R. Seifert, A. Buschauer, M. Kelley, 2001, The Journal of pharmacology and experimental therapeutics.

Integrative Case Studies

R. Seifert, 2019, Basic Knowledge of Pharmacology.

Human cyclic nucleotide phosphodiesterases possess a much broader substrate‐specificity than previously appreciated

R. Seifert, V. Kaever, P. Sandner, 2011, FEBS letters.

Adenylyl cyclases (ACs) in GtoPdb v.2023.1

C. Dessauer, R. Seifert, R. Ostrom, 2023, IUPHAR/BPS Guide to Pharmacology CITE.

Pseudomonas aeruginosa ExoY, a cyclic GMP- and cyclic UMP-generating nucleotidyl cyclase

R. Seifert, E. Kostenis, B. Tümmler, 2013, BMC Pharmacology and Toxicology.

Binding of Regulatory Subunits of Cyclic AMP-Dependent Protein Kinase to Cyclic CMP Agarose

R. Seifert, A. Pich, V. Kaever, 2012, PloS one.

Analysis of Substrate Specificity and Kinetics of Cyclic Nucleotide Phosphodiesterases with N’-Methylanthraniloyl-Substituted Purine and Pyrimidine 3′,5′-Cyclic Nucleotides by Fluorescence Spectrometry

R. Seifert, H. Genieser, F. Schwede, 2013, PloS one.

Sex Hormones: Hormonal Contraception and Hormone Replacement Therapy

R. Seifert, 2019, Basic Knowledge of Pharmacology.

Interactions of recombinant human histamine H1, H2, H3, and H4 receptors with 34 antidepressants and antipsychotics

A. Strasser, R. Seifert, S. Dove, 2012, Naunyn-Schmiedeberg's Archives of Pharmacology.

Guideline (S2k) on acute therapy and management of anaphylaxis - 2021 Update

H. Sitter, L. Klimek, O. Pfaar, 2021 .

Critical analysis of ginkgo preparations: comparison of approved drugs and dietary supplements marketed in Germany

R. Seifert, Milan Trabert, 2023, Naunyn-Schmiedeberg's archives of pharmacology.

Commercially available antibodies against human and murine histamine H4-receptor lack specificity

R. Seifert, D. Neumann, S. Beermann, 2012, Naunyn-Schmiedeberg's Archives of Pharmacology.

Synthetic lipopeptide Pam3CysSer(Lys)4 is an effective activator of human platelets.

G. Schultz, R. Seifert, S. Offermanns, 1994, The American journal of physiology.

Activation of superoxide formation and lysozyme release in human neutrophils by the synthetic lipopeptide Pam3Cys-Ser-(Lys)4. Involvement of guanine-nucleotide-binding proteins and synergism with chemotactic peptides.

G. Schultz, W. Bessler, R. Seifert, 1990, The Biochemical journal.

Complex changes in ecto-nucleoside 5′-triphosphate diphosphohydrolase expression in hypoxanthine phosphoribosyl transferase deficiency

R. Seifert, Cibele S. Pinto, V. Lorenz, 2007, Neuroscience Letters.

[Covid-19 vaccination and risk of anaphylaxis - Recommendations for practical management].

H. Sitter, L. Klimek, O. Pfaar, 2021, MMW Fortschritte der Medizin.

Histamine receptors in GtoPdb v.2021.3

H. Haas, J. Schwartz, R. Thurmond, 2021, IUPHAR/BPS Guide to Pharmacology CITE.

Drugs for the Treatment of Viral Infections

R. Seifert, 2019, Basic Knowledge of Pharmacology.

GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1–2 September 2014

Gebhard F. X. Schertler, Christofer S. Tautermann, Philip C. Biggin, 2015, Naunyn-Schmiedeberg's Archives of Pharmacology.

Probing Ligand-Specific Histamine H1- and H2-Receptor Conformations with NG-Acylated Imidazolylpropylguanidines

R. Seifert, A. Buschauer, S. Xie, 2006, Journal of Pharmacology and Experimental Therapeutics.

Synthesis and pharmacological characterization of novel fluorescent histamine H2-receptor ligands derived from aminopotentidine.

R. Seifert, A. Buschauer, S. Xie, 2006, Bioorganic & medicinal chemistry letters.

Histamine H1- and H4-receptor expression in human colon-derived cell lines

R. Seifert, M. König, D. Neumann, 2023, Naunyn-Schmiedeberg's Archives of Pharmacology.

Recent progress in the field of cIMP research

R. Seifert, 2016, Naunyn-Schmiedeberg's Archives of Pharmacology.

cIMP: Synthesis, effector activation, inactivation and occurrence in biological systems

R. Seifert, V. Kaever, H. Bähre, 2015, BMC Pharmacology and Toxicology.

Critical analysis of the prescription and evaluation of protein kinase inhibitors for oncology in Germany.

R. Seifert, Caecilia S Obst, 2023, Naunyn-Schmiedeberg's archives of pharmacology.

Receptor-mediated increases in cytosolic Ca2+ in the human erythroleukaemia cell line involve pertussis toxin-sensitive and -insensitive pathways.

G. Schultz, R. Seifert, I. Schwaner, 1992, The Biochemical journal.

Effects of Impromidine‐ and Arpromidine‐Derived Guanidines on Recombinant Human and Guinea Pig Histamine H1 and H2 Receptors

R. Seifert, A. Buschauer, S. Xie, 2007, Archiv der Pharmazie.

Regulation of G protein subunit composition in cardiomyocytes: pharmacological implications

R. Seifert, 2013, Naunyn-Schmiedeberg's Archives of Pharmacology.

Distinct Signaling Roles of cIMP, cCMP, and cUMP.

R. Seifert, 2016, Structure.

Lack of effect of opioid peptides, morphine and naloxone on superoxide formation in human neutrophils and HL-60 leukemic cells

G. Schultz, R. Seifert, R. Burde, 1989, Naunyn-Schmiedeberg's Archives of Pharmacology.

Drugs for Treatment of Depression and Bipolar Disorder

R. Seifert, 2019, Basic Knowledge of Pharmacology.

Cholinergic and Adrenergic System

R. Seifert, 2019, Basic Knowledge of Pharmacology.

Towards rational drug treatment of Lesch-Nyhan disease.

R. Seifert, 2016, Molecular genetics and metabolism.

Quantitative analysis of formyl peptide receptor coupling to g(i)alpha(1), g(i)alpha(2), and g(i)alpha(3).

R. Seifert, H. Y. Liu, J. Arthur, 1999, The Journal of biological chemistry.

Heterogeneity of pulmonary endothelial cyclic nucleotide response to Pseudomonas aeruginosa ExoY infection.

R. Seifert, V. Kaever, D. Frank, 2015, American journal of physiology. Lung cellular and molecular physiology.

Inhibitors of Bacillus anthracis edema factor.

R. Seifert, S. Dove, 2013, Pharmacology & therapeutics.

Differential Inhibition of Various Adenylyl Cyclase Isoforms and Soluble Guanylyl Cyclase by 2′,3′-O-(2,4,6-Trinitrophenyl)-Substituted Nucleoside 5′-Triphosphates

S. Sprang, R. Seifert, T. Mou, 2009, Journal of Pharmacology and Experimental Therapeutics.

GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1–2 September 2014

T. Ceska, P. Biggin, M. Bodkin, 2015, Naunyn-Schmiedeberg's Archives of Pharmacology.

α2A-adrenoceptors mediate activation of non-selective cation channels via Gi-proteins in human erythroleukaemia (HEL) cells

R. Seifert, I. Musgrave, 1995 .

Inhibition of the adenylyl cyclase toxin, edema factor, from Bacillus anthracis by a series of 18 mono- and bis-(M)ANT-substituted nucleoside 5′-triphosphates

R. Seifert, Wei-Jen Tang, Yuequan Shen, 2011, Naunyn-Schmiedeberg's Archives of Pharmacology.

Interaction of the Diguanylate Cyclase YdeH of Escherichia coli with 2′,(3′)-Substituted Purine and Pyrimidine Nucleotides

Roland Seifert, R. Seifert, V. Kaever, 2011, Journal of Pharmacology and Experimental Therapeutics.

Hydrolysis of the non-canonical cyclic nucleotide cUMP by PDE9A: kinetics and binding mode

R. Seifert, V. Kaever, E. Schneider, 2018, Naunyn-Schmiedeberg's Archives of Pharmacology.

3. Socioeconomic status, multiple risks, and development of intelligence

R. Seifert, 2001 .

Stimulation of histamine H2- (and H1)-receptors activates Ca2+ influx in all-atrans-retinoic acid-differentiated HL-60 cells independently of phospholipase C or adenylyl cyclase

R. Seifert, R. Burde, 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

The Yellow Color of Silver-Containing Zeolite A.

G. Calzaferri, R. Seifert, A. Kunzmann, 1998, Angewandte Chemie.

c-di-AMP signaling is required for bile salts resistance and long-term colonization by Clostridioides difficile

L. Bry, R. Seifert, B. Dupuy, 2021, bioRxiv.

No Evidence for Histamine H4 Receptor in Human Monocytes

R. Seifert, A. Buschauer, D. Neumann, 2014, The Journal of Pharmacology and Experimental Therapeutics.

Histamine H4-receptor expression in the brain?

R. Seifert, D. Neumann, E. Schneider, 2014, Naunyn-Schmiedeberg's Archives of Pharmacology.

Synthesis and Structure−Activity Relationships of Cyanoguanidine-Type and Structurally Related Histamine H4 Receptor Agonists§

A. Strasser, R. Seifert, Patrick Igel, 2009 .

N(G)-acylated imidazolylpropylguanidines as potent histamine H4 receptor agonists: selectivity by variation of the N(G)-substituent.

R. Seifert, Patrick Igel, A. Buschauer, 2009, Journal of medicinal chemistry.

Modulation of GPCRs by monovalent cations and anions

Hans-Joachim Wittmann, A. Strasser, R. Seifert, 2014, Naunyn-Schmiedeberg's Archives of Pharmacology.

Molecular and cellular analysis of human histamine receptor subtypes.

A. Strasser, R. Seifert, A. Buschauer, 2013, Trends in pharmacological sciences.

Nα-Methylated phenylhistamines exhibit affinity to the hH4R—a pharmacological and molecular modelling study

Hans-Joachim Wittmann, A. Strasser, R. Seifert, 2011, Naunyn-Schmiedeberg's Archives of Pharmacology.

Sf9 cells: a versatile model system to investigate the pharmacological properties of G protein-coupled receptors.

R. Seifert, E. Schneider, 2010, Pharmacology & therapeutics.

Interactions of Histamine H1-Receptor Agonists and Antagonists with the Human Histamine H4-Receptor

A. Strasser, R. Seifert, D. Neumann, 2009, Molecular Pharmacology.

Therapeutic Efficacy of a H4 Receptor Antagonist in Humans: A Milestone in Histamine Research

R. Seifert, 2014, The Journal of Pharmacology and Experimental Therapeutics.

Problems associated with the use of commercial and non-commercial antibodies against the histamine H4 receptor

R. Seifert, D. Jonigk, D. Neumann, 2012, Naunyn-Schmiedeberg's Archives of Pharmacology.

Analysis of Histamine Receptor Knockout Mice in Models of Inflammation

R. Seifert, D. Neumann, E. Schneider, 2014, The Journal of Pharmacology and Experimental Therapeutics.

Molecular Basis for the Selective Interaction of Synthetic Agonists with the Human Histamine H1-Receptor Compared with the Guinea Pig H1-Receptor

Hans-Joachim Wittmann, A. Strasser, R. Seifert, 2009, Molecular Pharmacology.

Ligand-Specific Contribution of the N Terminus and E2-Loop to Pharmacological Properties of the Histamine H1-Receptor

Hans-Joachim Wittmann, A. Strasser, R. Seifert, 2008, Journal of Pharmacology and Experimental Therapeutics.

Reconstitution of β2-adrenoceptor−GTP-binding-protein interaction in Sf9 cells

B. Kobilka, R. Seifert, T. Lee, 1998 .

Cationic-amphiphilic arpromidine-derived guanidines and a histamine trifluoromethyl-toluidide derivative may activate pertussis toxin-sensitive G-proteins by a receptor-independent mechanism

R. Seifert, A. Buschauer, B. Nürnberg, 1995, Naunyn-Schmiedeberg's Archives of Pharmacology.

Coexpression systems as models for the analysis of constitutive GPCR activity.

R. Seifert, E. Schneider, 2010, Methods in enzymology.

Functional Selectivity of GPCR Ligand Stereoisomers: New Pharmacological Opportunities

R. Seifert, S. Dove, 2009, Molecular Pharmacology.

Activation and Inhibition of Adenylyl Cyclase Isoforms by Forskolin Analogs

R. Seifert, Cibele S. Pinto, T. Mou, 2008, Journal of Pharmacology and Experimental Therapeutics.

Efficient adenylyl cyclase activation by a β2-adrenoceptor-Giα2 fusion protein

B. Kobilka, R. Seifert, J. Arthur, 2002 .

Restricting the mobility of Gs alpha: impact on receptor and effector coupling.

R Seifert, B. Kobilka, R. Seifert, 1999, Biochemistry.

Nα-Imidazolylalkyl and Pyridylalkyl Derivatives of Histaprodifen: Synthesis and in Vitro Evaluation of Highly Potent Histamine H1-Receptor Agonists

R. Seifert, H. Pertz, W. Schunack, 2003 .

Characterization of histamine Ha-receptors in human neutrophils with a series of guanidine analogues of impromidine Are cell type-specific Ha-receptors involved in the regulation of NADPH oxidase?

R. Seifert, A. Buschauer, R. Burde, 2022 .

R. Seifert, Liz Kinast, Heike Burhenne, 2012, Naunyn-Schmiedeberg's Archives of Pharmacology.

Preparations of Rp‐cyclic adenosine 3',5'‐phosphorothioate (Rp‐cAMPS) can contain biologically active amounts of adenosine

R. Seifert, E. Maronde, H. Genieser, 1993, FEBS letters.

Molsidomine inhibits the chemoattractant-induced respiratory burst in human neutrophils via a no-independent mechanism.

R. Seifert, J. Ervens, 1992, Biochemical pharmacology.

Low-affinity interactions of BODIPY-FL-GTPγS and BODIPY-FL-GppNHp with Gi- and Gs-proteins

R. Seifert, A. Gille, 2003, Naunyn-Schmiedeberg's Archives of Pharmacology.

Drugs for the Treatment of Alzheimer’s Disease

R. Seifert, 2019, Basic Knowledge of Pharmacology.