I. Beacham

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Transcription and regulation of the cpdB gene in Escherichia coli K12 and Salmonella typhimurium LT2: Evidence for modulation of constitutive promoters by cyclic AMP-CRP complex

Ju Liu, I. Beacham, 1990, Molecular and General Genetics MGG.

A Genomic Survey of Positive Selection in Burkholderia pseudomallei Provides Insights into the Evolution of Accidental Virulence

Wing-Kin Sung, William C. Nierman, Christina Nilsson, 2010, PLoS pathogens.

Pathogens Penetrating the Central Nervous System: Infection Pathways and the Cellular and Molecular Mechanisms of Invasion

Alan Mackay-Sim, Robert Norton, Glen C. Ulett, 2014, Clinical Microbiology Reviews.

L-asparaginase genes in Escherichia coli: isolation of mutants and characterization of the ansA gene and its protein product

I. Beacham, K. Spring, P. Jerlström, 1986, Journal of bacteriology.

Bacteriophage-resistant mutants of Escherichia coli K12. Location of receptors within the lipopolysaccharide.

I. Beacham, R. Picken, 1977, Journal of general microbiology.

Characterization of genomic DNA, mRNA and enzyme protein in cases of HPRT-deficiency.

B. Emmerson, R. Gordon, I. Beacham, 1989, Advances in experimental medicine and biology.

Temperature-sensitive mutants of Escherichia coli requiring saturated and unsaturated fatty acids for growth: isolation and properties.

I. Beacham, J. Cronan, D. F. Silbert, 1972, Proceedings of the National Academy of Sciences of the United States of America.

Transfer of RP4::Mu to Salmonella typhimurium.

I. Beacham, S. Garrett, 1981, Journal of general microbiology.

Degradation of triglycerides by a pseudomonad isolated from milk: molecular analysis of a lipase-encoding gene and its expression in Escherichia coli

I. Beacham, I. C. Macrae, M. Free, 1992, Applied and environmental microbiology.

Regulation of the aprX-lipA operon of Pseudomonas fluorescens B52: differential regulation of the proximal and distal genes, encoding protease and lipase, by ompR-envZ.

I. Beacham, C. McCarthy, R. Woods, 2004, FEMS microbiology letters.

Silent genes in prokaryotes

I. Beacham, 1987 .

Identification and sequence analysis of a silent gene (ushA0) in Salmonella typhimurium.

I. Beacham, D. M. Burns, 1986, Journal of molecular biology.

Silent genes in bacteria: the previously designated 'cryptic' ilvHI locus of 'Salmonella typhimurium LT2' is active in natural isolates.

I. Beacham, D. M. Burns, M. Burger, 1995, FEMS microbiology letters.

Burkholderia pseudomallei Penetrates the Brain via Destruction of the Olfactory and Trigeminal Nerves: Implications for the Pathogenesis of Neurological Melioidosis

A. Mackay-Sim, I. Beacham, R. Horton, 2014, mBio.

Burkholderia pseudomallei Rapidly Infects the Brain Stem and Spinal Cord via the Trigeminal Nerve after Intranasal Inoculation

I. Beacham, J. Ekberg, M. Batzloff, 2016, Infection and Immunity.

Nasal-associated lymphoid tissue and olfactory epithelium as portals of entry for Burkholderia pseudomallei in murine melioidosis.

A. Mackay-Sim, I. Beacham, M. Batzloff, 2009, The Journal of infectious diseases.

The role of signal sequence proximal residues in the mature region of bacterial secreted proteins in E. coli.

I. Beacham, Yaramah M. Zalucki, Joanna E Musik, 2022, Biochimica et biophysica acta. Biomembranes.

Human stomach class IV alcohol dehydrogenase: molecular genetic analysis.

I. Beacham, R. Holmes, B. Cheung, 1995, Alcoholism, clinical and experimental research.

Identification of new transposable genetic elements in Burkholderia pseudomallei using subtractive hybridisation.

A. E. Lew, I. Beacham, N. F. Brown, 2000, FEMS microbiology letters.

Transposon mutagenesis: Some factors influencing the frequency of translocation of Tn10 from the λ to the bacterial chromosome

I. Beacham, S. Garrett, 1979 .

Quorum Sensing Negatively Regulates Multinucleate Cell Formation during Intracellular Growth of Burkholderia pseudomallei in Macrophage-Like Cells

I. Beacham, R. Horton, M. Batzloff, 2013, PloS one.

Mutants of Escherichia coli "cryptic" for certain periplasmic enzymes: evidence for an alteration of the outer membrane

I. Beacham, D. Haas, E. Yagil, 1977, Journal of bacteriology.

Nucleoside Diphosphate Sugar Hydrolase Gene of Salmonella typhimurium: Chromosomal Location Determined by Intergeneric Crosses

I. Beacham, J. Gunn, N. Minton, 1979, Journal of bacteriology.

Molecular analysis of an esterase-encoding gene from a lipolytic psychrotrophic pseudomonad.

I. Beacham, D. Mckay, M. Jennings, 1992, Journal of general microbiology.

Membrane localisation of a UDP-sugar hydrolase, in Salmonella, is by an uncleaved N-terminal signal peptide.

I. Beacham, R. Jones, D. M. Burns, 1993, FEMS microbiology letters.

Cloning and sequencing of cDNA encoding baboon liver alcohol dehydrogenase: evidence for a common ancestral lineage with the human alcohol dehydrogenase beta subunit and for class I ADH gene duplications predating primate radiation.

I. Beacham, A. E. Trezíse, R. Holmes, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Exploring Bacterial Heparinase II Activities with Defined Substrates

I. Beacham, M. von Itzstein, Chih-Wei Chang, 2015, Chembiochem : a European journal of chemical biology.

Crypticity of periplasmic enzymes Involvement of protein b in the permeability of the outer membrane of Escherichia coli

I. Beacham, A. Nissim, E. Yagil, 1978, FEBS letters.

Molecular cloning of the gene (ush) from Escherichia coli specifying periplasmic UDP-sugar hydrolase (5'-nucleotidase).

I. Beacham, A. Cowman, 1980, Gene.

Nucleotide sequence and transcriptional analysis of the E. coli ushA gene, encoding periplasmic UDP-sugar hydrolase (5'-nucleotidase): regulation of the ushA gene, and the signal sequence of its encoded protein product.

I. Beacham, D. M. Burns, 1986, Nucleic acids research.

Novel insights into the glia limitans of the olfactory nervous system

I. Beacham, J. Ekberg, M. Batzloff, 2019, The Journal of comparative neurology.

Interaction of Burkholderia pseudomallei and Burkholderia thailandensis with human monocyte-derived dendritic cells.

I. Beacham, R. Horton, N. Morrison, 2012, Journal of medical microbiology.

The role of nucleoside phosphorylases in the degradation of deoxyribonucleosides by thymine-requiring mutants of E. coli

R. H. Pritchard, I. Beacham, 2004, Molecular and General Genetics MGG.

Regulation of the ansB gene of Salmonella enterica

I. Beacham, S. Scott, M. Jennings, 1993, Molecular microbiology.

Periplasmic enzymes in gram-negative bacteria.

I. Beacham, 1979, The International journal of biochemistry.

Evolution of class I alcohol dehydrogenase genes in catarrhine primates: gene conversion, substitution rates, and gene regulation.

S. Easteal, I. Beacham, R. Holmes, 1999, Molecular biology and evolution.

Cloning and molecular analysis of the Salmonella enterica ansP gene, encoding an L-asparagine permease.

I. Beacham, M. Jennings, J. Anderson, 1995, Microbiology.

The role of the intracellular inhibitor of periplasmic UDP‐sugar hydrolase (5′‐nucleotidase) in Escherichia coli: cytoplasmic localisation of 5′‐nucleotidase is conditionally lethal

I. Beacham, D. M. Burns, D. Innes, 2001, Journal of basic microbiology.

Degradation of triglycerides by a pseudomonad isolated from milk: the roles of lipase and esterase studied using recombinant strains over-producing, or specifically deficient in these enzymes.

I. Beacham, D. Mckay, M. Dieckelmann, 1995, The Journal of applied bacteriology.

Invasionand Molecular Mechanisms of System: Infection Pathways and the Pathogens Penetrating the Central Nervous

A. Mackay-Sim, I. Beacham, J. Ekberg, 2014 .

Co‐dependent positive regulation of the ansBF promoter of Escherichia coli by CRP and the FNR protein: a molecular analysis

I. Beacham, M. Jennings, M P Jennings, 1993, Molecular microbiology.

Analysis of the Escherichia coli gene encoding L-asparaginase II, ansB, and its regulation by cyclic AMP receptor and FNR proteins

I. Beacham, M. Jennings, Michael P. Jennings, 1990, Journal of bacteriology.

Uptake of adenosine 5'-monophosphate by Escherichia coli

I. Beacham, E. Yagil, 1975, Journal of bacteriology.

Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.

Kim Rutherford, Julian Parkhill, Ben Crossett, 2004, Proceedings of the National Academy of Sciences of the United States of America.

A Type IV Pilin, PilA, Contributes to Adherence of Burkholderia pseudomallei and Virulence In Vivo

I. Beacham, R. Titball, N. F. Brown, 2005, Infection and Immunity.

Genetic Tools for Select-Agent-Compliant Manipulation of Burkholderia pseudomallei

I. Beacham, H. Schweizer, Ayush Kumar, 2007, Applied and Environmental Microbiology.

The inducer of the deoxynucleoside phosphorylases and deoxyriboaldolase in Escherichia coli.

R. H. Pritchard, I. Beacham, S. Ahmad, 1968, Biochimica et biophysica acta.

Facile construction of unmarked deletion mutants in Burkholderia pseudomallei using sacB counter-selection in sucrose-resistant and sucrose-sensitive isolates.

I. Beacham, I. Peak, C. Logue, 2009, Journal of microbiological methods.

Burkholderia pseudomallei Capsule Exacerbates Respiratory Melioidosis but Does Not Afford Protection against Antimicrobial Signaling or Bacterial Killing in Human Olfactory Ensheathing Cells

I. Beacham, J. Ekberg, D. Crossman, 2016, Infection and Immunity.

The cryptic ushA gene (ushA(c)) in natural isolates of Salmonella enterica (serotype Typhimurium) has been inactivated by a single missense mutation.

I. Beacham, Michael W. Laird, J. Joly, 2001, Microbiology.

Cloning and analysis of genomic differences unique to Burkholderia pseudomallei by comparison with B. thailandensis.

I. Beacham, N. F. Brown, 2000, Journal of medical microbiology.

Bacteriophage-resistant mutants of Escherichia coli K12 with altered lipopolysaccharide. Studies with concanavalin A.

I. Beacham, R. Picken, 1977, Journal of general microbiology.

Temperature-Regulated Microcolony Formation by Burkholderia pseudomallei Requires pilA and Enhances Association with Cultured Human Cells

I. Beacham, J. Boddey, I. Peak, 2006, Infection and Immunity.

Identification of a novel two-partner secretion system from Burkholderia pseudomallei

I. Beacham, R. Hirst, N. F. Brown, 2004, Molecular Genetics and Genomics.

Adherence of Burkholderia pseudomallei Cells to Cultured Human Epithelial Cell Lines Is Regulated by Growth Temperature

I. Beacham, N. F. Brown, J. Boddey, 2002, Infection and Immunity.

Rare codons in E. coli and S. typhimurium signal sequences

D M Burns, I. Beacham, I R Beacham, 1985, FEBS letters.

A method for the ligation of DNA following isolation from low melting temperature agarose.

I. Beacham, D. M. Burns, 1983, Analytical biochemistry.

A new assay for phosphodeoxyribomutase: surface localisation of the enzyme.

I. Beacham, 1969, Biochimica et biophysica acta.

Constitutivity of thymidine phosphorylase in deoxyriboaldolase negative strains: dependence on thymine requirement and concentration.

R. H. Pritchard, I. Beacham, P. Barth, 1968, Biochimica et biophysica acta.

Intracellular thymidine triphosphate concentrations in wild type and in thymine requiring mutants of Escherichia coli 15 and K12.

R. H. Pritchard, I. Beacham, A. Zaritsky, 1971, Journal of molecular biology.

Deoxynucleoside-sensitive mutants ofSalmonella typhimurium

R. H. Pritchard, I. Beacham, A. Eisenstark, 2005, Molecular and General Genetics MGG.

A strain of Pseudomonas fluorescens with two lipase‐encoding genes, one of which possibly encodes cytoplasmic lipolytic activity

I. Beacham, M. Dieckelmann, C. Beven, 2001, Journal of applied microbiology.

Evidence for three genes encoding class-I alcohol dehydrogenase subunits in baboon and analysis of the 5' region of the gene encoding the ADH beta subunit.

I. Beacham, A. E. Trezíse, R. Holmes, 1991, Gene.

The nucleotide sequence of the yeast ARG4 gene.

B. Schweitzer, I. Beacham, J. Carbon, 1984, Gene.

The effect of translation and transcription inhibitors on the synthesis of periplasmic phosphatases in E. coli

I. Beacham, M. Wainwright, 1977, Molecular and General Genetics MGG.

Enzyme secretion in Escherichia coli: synthesis of alkaline phosphatase and acid hexose phosphatase in the absence of phospholipid synthesis

I. Beacham, N. Taylor, M. Youell, 1976, Journal of bacteriology.

Burkholderia pseudomallei invades the olfactory nerve and bulb after epithelial injury in mice and causes the formation of multinucleated giant glial cells in vitro

I. Beacham, J. Ekberg, M. Batzloff, 2020, PLoS neglected tropical diseases.

Burkholderia pseudomallei sequencing identifies genomic clades with distinct recombination, accessory, and epigenetic profiles

P. Baybayan, J. Parkhill, X. Didelot, 2015, Genome research.

Burkholderia pseudomallei sequencing identifies genomic clades with distinct recombination, accessory, and epigenetic profiles.

P. Baybayan, J. Parkhill, X. Didelot, 2015, Genome research.

Biased codon usage in signal peptides: a role in protein export.

I. Beacham, M. Jennings, Ifor R Beacham, 2009, Trends in microbiology.

Whole genome analysis reveals a high incidence of non-optimal codons in secretory signal sequences of Escherichia coli.

I. Beacham, M. Jennings, C. Bucholtz, 2004, Biochemical and biophysical research communications.

Temperature regulation of protease in Pseudomonas fluorescens LS107d2 by an ECF sigma factor and a transmembrane activator.

I. Beacham, R. G. Woods, C. McCarthy, 2000, Microbiology.

Evaluation of recombinant antigens for diagnosis of melioidosis.

I. Beacham, N. Ketheesan, I. Peak, 2008, FEMS immunology and medical microbiology.

The interaction of concanavalin A with mutant and wild-type strains of Escherichia coli K12.

I. Beacham, R. Picken, 1975, Biochemical Society transactions.

Positive selection vectors: a small plasmid vector useful for the direct selection of Sau3A-generated overlapping DNA fragments.

I. Beacham, D. M. Burns, 1984, Gene.

Distinct physiological roles for the two L-asparaginase isozymes of Escherichia coli.

I. Beacham, M. Jennings, John M. Atack, 2013, Biochemical and biophysical research communications.

Isolation of Escherichia coli mutants (cpdB) deficient in periplasmic 2':3'-cyclic phosphodiesterase and genetic mapping of the cpdB locus.

I. Beacham, S. Garrett, 1980, Journal of general microbiology.

Structure and expression in Escherichia coli K-12 of the L-asparaginase I-encoding ansA gene and its flanking regions.

I. Beacham, M. Jennings, P. Jerlström, 1989, Gene.

Phagocytosis of bacteria by olfactory ensheathing cells and Schwann cells

A. Mackay-Sim, I. Beacham, J. Ekberg, 2013, Neuroscience Letters.

Characterization of the ush gene of Escherichia coli and its protein products.

I. Beacham, L. Abraham, D. M. Burns, 1983, Gene.

Expression of active human hypoxanthine-guanine phosphoribosyltransferase in Escherichia coli and characterisation of the recombinant enzyme.

B. Emmerson, R. Gordon, I. Beacham, 1990, Biochimica et biophysica acta.

Isolation and sequence analysis of the gene (cpdB) encoding periplasmic 2',3'-cyclic phosphodiesterase

J. Liu, I. Beacham, D. M. Burns, 1986, Journal of bacteriology.

Identification of a single nucleotide substitution in the coding sequence ofin vitro amplified cDNA from a patient with partial HPRT deficiency (HPRTBrisbane)

P. Dawson, B. Emmerson, R. Gordon, 1990, Journal of Inherited Metabolic Disease.

Hypoxanthine-guanine phosphoribosyltransferase deficiency: analysis of HPRT mutations by direct sequencing and allele-specific amplification

P. Dawson, B. Emmerson, R. Gordon, 1991, Human Genetics.

Site-specific mutagenesis of Escherichia coli asparaginase II. None of the three histidine residues is required for catalysis.

I. Beacham, P. Bast, M. Jennings, 1992, European journal of biochemistry.

Construction of expression systems for Escherichia coli asparaginase II and two-step purification of the recombinant enzyme from periplasmic extracts.

I. Beacham, M. Jennings, K. Röhm, 1991, Protein expression and purification.

UDP-sugar hydrolase isozymes in Salmonella enterica and Escherichia coli: silent alleles of ushA in related strains of group I Salmonella isolates, and of ushB in wild-type and K12 strains of E. coli, indicate recent and early silencing events, respectively.

I. Beacham, C. Edwards, D. M. Burns, 1993, FEMS microbiology letters.

Bacterial UDP-glucose hydrolases and P2 receptor-mediated responses to infection: A commentary

I. Beacham, J. Headrick, 2013 .

Functional and structural characterization of a heparanase.

Gregory D. Tredwell, J. Tiralongo, I. Beacham, 2015, Nature chemical biology.

Cobalt activation of Escherichia coli 5'-nucleotidase is due to zinc ion displacement at only one of two metal-ion-binding sites.

I. Beacham, D. M. Burns, L. McMillen, 2003, The Biochemical journal.

Mutants of Escherichia coli K-12 “Cryptic,” or Deficient in 5′-Nucleotidase (Uridine Diphosphate-Sugar Hydrolase) and 3′-Nucleotidase (Cyclic Phosphodiesterase) Activity

I. Beacham, E. Yagil, L. Levy, 1973, Journal of bacteriology.

Enzyme secretion in E. coli K12 : studies on alkaline phosphatase synthesis using an unsaturated fatty-acid auxotroph.

I. Beacham, S. Jones, 1978, Biochemical and biophysical research communications.

Regulation of Escherichia colil‐asparaginase II and l‐aspartase by the fnr gene‐product

Ju Liu, I. Beacham, P. Jerlström, 1987 .

Genetic Tools for Select-Agent-Compliant Manipulation of Burkholderia pseudomallei

I. Beacham, H. Schweizer, Ayush Kumar, 2008, Applied and Environmental Microbiology.

The aprX-lipA operon of Pseudomonas fluorescens B52: a molecular analysis of metalloprotease and lipase production.

I. Beacham, R. G. Woods, M. Burger, 2001, Microbiology.

The bacterial gene lfpA influences the potent induction of calcitonin receptor and osteoclast‐related genes in Burkholderia pseudomallei‐induced TRAP‐positive multinucleated giant cells

I. Beacham, R. Ulrich, N. Morrison, 2007, Cellular microbiology.

Transcriptional co‐activation at the ansB promoters: involvement of the activating regions of CRP and FNR when bound in tandem

I. Beacham, S. Busby, S. Scott, 1995, Molecular microbiology.

Coupling between codon usage, translation and protein export in Escherichia coli

I. Beacham, Ifor R Beacham, Michael P Jennings, 2011, Biotechnology journal.

Nasal-associated lymphoid tissue and olfactory epithelium as portals of entry for Burkholderia pseudomallei in murine melioidosis.

A. Mackay-Sim, I. Beacham, M. Batzloff, 2009, The Journal of infectious diseases.