J. Kay

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Subsite preferences of retroviral proteinases.

A. Wlodawer, B. Dunn, A. Gustchina, 1994, Methods in enzymology.

Different requirements for productive interaction between the active site of HIV-1 proteinase and substrates containing -hydrophobic*hydrophobic- or -aromatic*pro- cleavage sites.

A. Wlodawer, B. Dunn, A. Gustchina, 1992, Biochemistry.

[14]Subsite preferences of retroviral proteinases

A. Wlodawer, B. Dunn, A. Gustchina, 1994 .

The aspartic proteinase from Saccharomyces cerevisiae folds its own inhibitor into a helix

Alexander Wlodawer, Mi Li, Jakob R. Winther, 2000, Nature Structural Biology.

High resolution X-ray analyses of renin inhibitor-aspartic proteinase complexes

T. L. Blundell, B. L. Sibanda, L. H. Pearl, 1987, Nature.

Adaptation of the behaviour of an aspartic proteinase inhibitor by relocation of a lysine residue by one helical turn

Colin Berry, D. M. Wyatt, J. Kay, 2006, Biological chemistry.

A consensus sequence for substrate hydrolysis by rhino virus 3C proteinase

B. Dunn, J. Kay, J. Cameron, 1989, FEBS Letters.

Identification of the acid proteinase in human seminal fluid as a gastricsin originating in the prostate

J. Kay, M. Valler, J. Svasti, 2004, Cell and Tissue Research.

The interaction of aspartic proteinases with naturally-occurring inhibitors from actinomycetes and Ascaris lumbricoides.

B. Dunn, J. Kay, M. Valler, 1985, Journal of enzyme inhibition.

Gastricsin in the benign and malignant prostate.

J. Kay, J. Svasti, C. Liddle, 1985, Journal of clinical pathology.

Molecular organization, expression and chromosomal localization of the mouse pronapsin gene.

J. Kay, P. Tatnell, M. Cook, 2000, European journal of biochemistry.

Comparison of the specificity of the aspartic proteinases towards internally consistent sets of oligopeptide substrates.

W. Lowther, B. Dunn, J. Kay, 1998, Advances in experimental medicine and biology.

Plasmepsins I and II from the malarial parasite Plasmodium falciparum.

B. Dunn, J. Kay, H. Loetscher, 1998, Advances in experimental medicine and biology.

Exploring the binding preferences/specificity in the active site of human cathepsin E

T. Blundell, B. Dunn, J. Kay, 1995, Proteins.

Human cathepsin E produced in E. coli

J. Kay, J. Hill, D. Montgomery, 1993, FEBS letters.

The pH dependence of the hydrolysis of chromogenic substrates of the type, Lys-Pro-Xaa-Yaa-Phe-(NO2)Phe-Arg-Leu, by selected aspartic proteinases: evidence for specific interactions in subsites S3 and S2.

B. Dunn, J. Kay, M. Valler, 1987, Biochimica et biophysica acta.

Comparison of kinetic properties of native and recombinant human cathepsin D.

B. Dunn, J. Kay, G. Conner, 1991, Advances in experimental medicine and biology.

Degradation of smooth-muscle myosin by trypsin-like serine proteinases.

J. Kay, D. E. Goll, R. F. Siemankowski, 1982, The Biochemical journal.

The aspartic proteinase family of three Phytophthora species

J. Kay, J. V. van Kan, H. Meijer, 2011, BMC Genomics.

Antigen processing for presentation by class II major histocompatibility complex requires cleavage by cathepsin E

J. Kay, B. Chain, T. Levine, 1992, European journal of immunology.

Natural processing sites for human cathepsin E and cathepsin D in tetanus toxin: implications for T cell epitope generation.

J. Kay, N. Morrice, C. Watts, 1997, Journal of immunology.

A DIFFERENT FORM OF THE Ca2+-DEPENDENT PROTEINASE ACTIVATED BY MICROMOLAR LEVELS OF Ca2+

J. Kay, D. E. Goll, Y. Otsuka, 1981 .

Analysis of latent forms of renin using antibodies raised against the propart segment of human prorenin: validation with representative samples of ovarian cyst and follicular fluids.

J. Kay, W. E. Lees, P. Charlton, 1993, Clinical and experimental hypertension.

Key Features Determining the Specificity of Aspartic Proteinase Inhibition by the Helix-forming IA3 Polypeptide*

D. M. Wyatt, J. Kay, L. H. Phylip, 2007, Journal of Biological Chemistry.

Expression, purification, and characterization of the recombinant pepsin inhibitor from Ascaris suum.

B. Dunn, J. Kay, C. Rao-Naik, 1998, Advances in experimental medicine and biology.

Extensive Expansion of A1 Family Aspartic Proteinases in Fungi Revealed by Evolutionary Analyses of 107 Complete Eukaryotic Proteomes

J. Kay, J. V. van Kan, A. ten Have, 2014, Genome biology and evolution.

Slow moving proteinase. Isolation, characterization, and immunohistochemical localization in gastric mucosa.

J. Kay, M. Valler, R. Lewis, 1987, Gastroenterology.

Human Aspartic Proteinases

J. Kay, D. Bur, 2011 .

Ca2-activated proteinases, protein degradation and muscular dystrophy.

J. Kay, 1984, Advances in experimental medicine and biology.

Immunogold electron-microscopic localisation of calpain I in skeletal muscle of rats

J. Kay, B. Jasani, N. Yoshimura, 2004, Cell and Tissue Research.

Regulation of cathepsin E expression during human B cell differentiation in vitro

J. Kay, B. Chain, N. Rayment, 1996, European journal of immunology.

Substrate cleavage by HIV-1 proteinase.

V. Kostka, W. Farmerie, B. Dunn, 1991, Advances in experimental medicine and biology.

Aspartic proteinases and inhibitors for their control in health and disease.

B. Dunn, J. Kay, C. Norey, 1988, Advances in experimental medicine and biology.

Generation of human endothelin by cathepsin E

J. Kay, W. E. Lees, S. Kalinka, 1990, FEBS letters.

Regulation of human and mouse procathepsin E gene expression.

J. Kay, R. Caswell, R. Richards, 2001, European journal of biochemistry.

Conversion of pepsinogen into pepsin is not a one-step process.

C. Dykes, J. Kay, 1976, The Biochemical journal.

Identification of primary tumour site by immunolocalization of progastricsin in metastatic adenocarcinoma

J. Kay, W. Reid, T. Branch, 1990, The Journal of pathology.

Immunolocalisation of cathepsin D in normal and neoplastic human tissues kidney

J. Kay, M. Valler, W. Reid, 2005 .

Pronapsin A and B gene expression in normal and malignant human lung and mononuclear blood cells.

J. Kay, F. Bühling, S. Ansorge, 2002, Biochimica et biophysica acta.

Shewasin A, an active pepsin homolog from the bacterium Shewanella amazonensis

J. Kay, I. Simões, C. Faro, 2011, The FEBS journal.

Intracellular protein degradation.

J. Kay, 1978, Biochemical Society transactions.

Inhibition of aspartic proteinases by alpha 2-macroglobulin.

J. Kay, D. Thomas, A. Richards, 1989, The Biochemical journal.

Identification of the aspartic proteinases from human erythrocyte membranes and gastric mucosa (slow-moving proteinase) as catalytically equivalent to cathepsin E.

B. Dunn, J. Kay, J. Wyckoff, 1988, The Biochemical journal.

Mouse procathepsin E gene: molecular organisation and chromosomal localisation.

J. Deussing, C. Peters, J. Kay, 1998, Biochimica et biophysica acta.

Structure of equine infectious anemia virus proteinase complexed with an inhibitor

A. Wlodawer, A. Gustchina, J. Kay, 1996 .

CGP 38 560: Orally Active, Low‐Molecular‐Weight Renin Inhibitor with High Potency and Specificity

J. Wood, J. Kay, M. de Gasparo, 1989, Journal of cardiovascular pharmacology.

Incorporation of choline and ethanolamine into phospholipids in germinating soya bean.

C. Dykes, J. Kay, J. Harwood, 1976, The Biochemical journal.

Human Herpesvirus Type 6 Assemblin

J. Kay, N. Tigue, R. Jupp, 2013 .

Characterization of the proteinase specified by varicella-zoster virus gene 33.

J. Kay, D. McMillan, J. Mills, 1997, The Journal of general virology.

An assay to differentiate the "true" activity of pepsin from the potential activity of pepsinogen.

J. Kay, 1975, Analytical biochemistry.

Hydrolysis of a series of synthetic peptide substrates by the human rhinovirus 14 3C proteinase, cloned and expressed in Escherichia coli.

B. Dunn, J. Kay, J. Cameron, 1989, The Journal of general virology.

Rational design of peptide-based HIV proteinase inhibitors.

I B Duncan, J. Kay, D. Taylor, 1990, Science.

Viral proteinases: weakness in strength.

B. Dunn, J. Kay, J. Kay, 1990, Biochimica et biophysica acta.

The chymotrypsin catalysed activation of glutamate dehydrogenase

J. Kay, R. Beynon, 1976 .

Aspartic proteases of Plasmodium falciparum and other parasitic protozoa as drug targets.

D. Goldberg, M. Klemba, G. H. Coombs, 2001, Trends in parasitology.

In vitro inhibition of HIV‐1 proteinase by cerulenin

Thomas Schulze, Karin Moelling, L. Pearl, 1990, FEBS letters.

Pepsinogen in gastric carcinoma cells

J. Kay, W. Reid, W. Thompson, 1983, Journal of clinical pathology.

Slow moving proteinase

J. Kay, M. Valler, R. Taggart, 1987 .

Immunolocalization of cathepsin D in normal and neoplastic human tissues.

J. Kay, M. Valler, W. Reid, 1986, Journal of clinical pathology.

The activation of bovine pepsinogen. Sequence of the peptides released, identification of a pepsin inhibitor.

J. Kay, B. Kassell, B. Foltmann, 1974, The Journal of biological chemistry.

A systematic series of synthetic chromophoric substrates for aspartic proteinases.

B. Dunn, J. Kay, M. Valler, 1986, The Biochemical journal.

The effect of diffusion on the immunolocalization of antigen

J. Kay, W. Thompson, W. Reid, 1987, Histopathology.

PEPSIN-LIKE PROTEINASES AND THEIR PRECURSORS RENNET SUBSTITUTES FOR CHEESE MAKING

J. Kay, M. Valler, H. Keilová, 1981 .

6 – Cathepsin E

J. Kay, 2004 .

Sub‐site preferences of the aspartic proteinase from the human immunodeficiency virus, HIV‐1

V. Kostka, B. Dunn, J. Kay, 1990, FEBS letters.

Effective blocking of HIV‐1 proteinase activity by characteristic inhibitors of aspartic proteinases

B. Dunn, J. Kay, A. Richards, 1989, FEBS letters.

The inactivation of native enzymes by a neutral proteinase from rat intestinal muscle.

J. Kay, R. Beynon, 1978, The Biochemical journal.

A possible role for neutral proteolysis in the degradation of intracellular proteins.

J. Kay, 1979, Ciba Foundation symposium.

Alkaline proteinase localization in myoblasts.

J. Kay, W. Stauber, B. Dahlmann, 1987, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Toward a universal inhibitor of retroviral proteases: Comparative analysis of the interactions of LP‐130 complexed with proteases from HIV‐1, FIV, and EIAV

K Y Hui, A Wlodawer, A. Wlodawer, 1998, Protein science : a publication of the Protein Society.

The autoactivation of trypsinogen.

J. Kay, B. Kassell, 1971, The Journal of biological chemistry.

HIV-1 Diversity in Tanzania and its Implication toward Development of Effective Vaccines: A Review Article

J. Kay, B. Nyombi, E. Shao, 2014 .

An aspartic proteinase gene family in the filamentous fungus Botrytis cinerea contains members with novel features.

J. Kay, L. H. Phylip, J. V. van Kan, 2004, Microbiology.

The Potency and Specificity of the Interaction between the IA3 Inhibitor and Its Target Aspartic Proteinase fromSaccharomyces cerevisiae *

Alexander Wlodawer, Mi Li, Jakob R. Winther, 2001, The Journal of Biological Chemistry.

Substrate specificity and inhibitors of aspartic proteinases.

B. Dunn, J. Kay, 1992, Scandinavian journal of clinical and laboratory investigation. Supplementum.

Naturally‐occurring and recombinant forms of the aspartic proteinases plasmepsins I and II from the human malaria parasite Plasmodium f alciparum

I. Gluzman, D. Goldberg, J. Kay, 1999, FEBS letters.

A semicontinuous assay for glycogen phosphorylase.

J. Kay, R. Beynon, I. Carney, 1978, Analytical Biochemistry.

Expression and characterisation of plasmepsin I from Plasmodium falciparum.

U. Certa, B. Dunn, J. Kay, 1997, European journal of biochemistry.

Cathepsin E. The best laid plans of mice and men.

J. Kay, W. E. Lees, D. Bur, 1998, Advances in experimental medicine and biology.

Cloning, expression and characterisation of murine procathepsin E

J. Kay, W. E. Lees, P. Tatnell, 1997, FEBS letters.

Hydrolysis of synthetic chromogenic substrates by HIV-1 and HIV-2 proteinases.

V. Kostka, J. Kay, L. H. Phylip, 1990, Biochemical and biophysical research communications.

Inhibition of the aspartic proteinase from HIV‐2

B. Dunn, J. Kay, A. Ritchie, 1989, FEBS letters.

The selectivity of action of the aspartic-proteinase inhibitor IA3 from yeast (Saccharomyces cerevisiae).

B. Dunn, J. Kay, P. Charlton, 1985, The Biochemical journal.

Aspartic proteinase inhibitors from tomato and potato are more potent against yeast proteinase A than cathepsin D.

J. Kay, L. H. Phylip, W. E. Lees, 2002, Biochimica et biophysica acta.

An alternatively spliced variant of cathepsin E in human gastric adenocarcinoma cells.

J. Kay, P. Tatnell, M. Cook, 2003, Biochimica et biophysica acta.

Stabilisation of cathepsin E by ATP

B. Dunn, J. Kay, I. Samloff, 1989, FEBS letters.

Monomeric human cathepsin E

B. Dunn, J. Kay, Sylvia D. Fowler, 1995, FEBS letters.

Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1'-P2' variation.

C. Humblet, E. Lunney, B. Dunn, 1993, Journal of medicinal chemistry.

Napsins: new human aspartic proteinases

J. Kay, T. Smith, D. Tew, 1998, FEBS letters.

The aspartic proteinase from Saccharomyces cerevisiae folds its own inhibitor into a helix.

A. Wlodawer, B. Dunn, A. Gustchina, 2000 .

Zymogens of Proteolytic Enzymes

J. Kay, B. Kassell, 1973, Science.

Degradation of myofibrillar proteins by trypsin-like serine proteinases.

J. Kay, D. E. Goll, R. F. Siemankowski, 1982, The Biochemical journal.

Processing, Activity, and Inhibition of Recombinant Cyprosin, an Aspartic Proteinase from Cardoon (Cynara cardunculus)*

J. Kay, P. White, P. Brodelius, 1999, The Journal of Biological Chemistry.

Neutral proteinases involved in muscle protein breakdown

J. Kay, N. Yoshimura, B. Dahlmann, 1985 .

Autoprocessing and Peptide Substrates for Human Herpesvirus 6 Proteinase*

J. Kay, N. Tigue, Natalie J. Tigue, 1998, The Journal of Biological Chemistry.

Cloning, expression and characterization of the proteinase from human herpesvirus 6

J. Kay, N. Tigue, N. Roberts, 1996, Journal of virology.

The first cleavage site in pepsinogen activation.

C. Dykes, J. Kay, 1977, Advances in experimental medicine and biology.

Interaction of pepstatin with pig pepsinogen.

C. Dykes, J. Kay, 1976, Biochemical Journal.

The first step in the activation of chicken pepsinogen is similar to that of prochymosin.

V. Kostka, J. Kay, H. Keilová, 1977, The Biochemical journal.

Quantitative structure activity relationship of IA3‐like peptides as aspartic proteinase inhibitors

Colin Berry, J. Kay, John Kay, 2009, Proteins.

Inhibition of aspartic proteinases by synthetic peptides derived from the propart region of human prorenin.

B. Dunn, J. Kay, P. Charlton, 1992, The International journal of biochemistry.

Lipase-induced alterations of fatty acid synthesis by subcellular fractions from germinating pea (Pisum sativum L.).

J. Kay, J. Harwood, B. Jordan, 1982, The Biochemical journal.

Sequence, expression and modeled structure of an aspartic proteinase from the human malaria parasite Plasmodium falciparum.

G. Reddy, J. Dame, C. Yowell, 1994, Molecular and biochemical parasitology.

Structure of equine infectious anemia virus proteinase complexed with an inhibitor

A. Wlodawer, A. Gustchina, J. Kay, 1996, Protein science : a publication of the Protein Society.

High level expression and characterisation of Plasmepsin II, an aspartic proteinase from Plasmodium falciparum

B. Dunn, J. Kay, L. H. Phylip, 1994, FEBS letters.

Interactions of substrates and inhibitors with a family of tethered HIV-1 and HIV-2 homo- and heterodimeric proteinases.

B. Dunn, J. Kay, J. T. Griffiths, 1994, The Journal of biological chemistry.

Escape mutants of HIV-1 proteinase: enzymic efficiency and susceptibility to inhibition.

J S Mills, B. Dunn, S. Gulnik, 1997, Biochimica et biophysica acta.

Expression, characterisation and mutagenesis of the aspartic proteinase from equine infectious anaemia virus.

A. Wlodawer, B. Dunn, A. Gustchina, 1996, European journal of biochemistry.

Multicatalytic proteinase activity in skeletal muscle from starving rat

J. Kay, H. Reinauer, B. Dahlmann, 1987 .

Studies on plasmepsins I and II from the malarial parasite Plasmodium falciparum and their exploitation as drug targets.

U. Certa, J. Kay, A. D'arcy, 1998, Advances in experimental medicine and biology.

The Botrytis cinerea aspartic proteinase family.

J. Kay, J. V. van Kan, A. ten Have, 2010, Fungal genetics and biology : FG & B.

Mutating P2 and P1 residues at cleavage junctions in the HIV‐1 pol polyprotein Effects on hydrolysis by HIV‐1 proteinase

J. Kay, L. H. Phylip, S. L. Le Grice, 1991, FEBS letters.

Active site mutants of human herpesvirus‐6 proteinase

J. Kay, N. Tigue, 1998, FEBS letters.

Varicella-Zoster Virus Assemblin

J. Kay, D. McMillan, R. Jupp, 2013 .

A distinct member of the aspartic proteinase gene family from the human malaria parasite Plasmodium falciparum

U. Certa, J. Kay, D. Bur, 1999, FEBS letters.

A low-molecular-weight inhibitor of the neutral proteinase from rat intestinal smooth muscle.

J. Kay, C. Curtis, I. Carney, 1980, The Biochemical journal.

Aspartic proteinases from the human malaria parasite Plasmodium falciparum.

J. Dame, B. Dunn, J. Kay, 1994, Advances in experimental medicine and biology.

Aspartic proteinases from parasites.

B. Dunn, J. Kay, C. Berry, 1996, Advances in experimental medicine and biology.

X-ray studies of aspartic proteinase-statine inhibitor complexes.

T L Blundell, T. Blundell, J. Cooper, 1991, Biochemistry.

Design, synthesis and analysis of new synthetic substrates for the aspartic proteinases.

B. Dunn, J. Kay, 1985, Biochemical Society transactions.

Intracellular protein degradation.

J. Kay, 1978, Biochemical Society Transactions.

Aspartic proteinases and their inhibitors.

J. Kay, J. Kay, J Kay, 1985, Biochemical Society transactions.

Molecular cloning and sequence determination of a novel aspartic proteinase from Antarctic fish.

J. Kay, P. Kille, V. Carginale, 1998, Biochimica et biophysica acta.

Immunolocalisation of aspartic proteinases in the developing human stomach.

J. Kay, W. Thompson, W. Reid, 1989, Journal of developmental physiology.

Binding of mutant hiv-i proteases with junction b peptides containing methyleneamino isostere replacements

B. Dunn, J. Kay, L. Zhang, 1997, Protein & Peptide Letters.

Assessment of the suitability for Cheddar cheesemaking of purified and commercial chicken pepsin preparations

J. Kay, M. L. Green, M. Valler, 1984, Journal of Dairy Research.

Recombinant human cathepsin E.

J. Kay, J. Hill, D. Montgomery, 1995, Advances in experimental medicine and biology.

Interaction of aspartic proteinases with a new series of synthetic substrates and with inhibitors based on the propart of porcine pepsinogen

B. Dunn, J. Kay, M. Valler, 1985 .

Shewasin A, an active pepsin homolog from the bacterium Shewanella amazonensis

J. Kay, I. Simões, C. Faro, 2011, The FEBS journal.