L. Gabryelski

发表

In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors

J. Condra, W. Schleif, O. M. Blahy, 1995, Nature.

Genetic correlates of in vivo viral resistance to indinavir, a human immunodeficiency virus type 1 protease inhibitor

J. Mellors, J. Condra, W. Schleif, 1996, Journal of virology.

A combinatorial library of indinavir analogues and its in vitro and in vivo studies.

Yuan Cheng, Xin Xu, Lawrence C Kuo, 2002, Bioorganic & medicinal chemistry letters.

A potent and orally active HIV-1 integrase inhibitor.

Wei Xu, D. Hazuda, Michael D. Miller, 2007, Bioorganic & medicinal chemistry letters.

Design and synthesis of substituted 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxamides, novel HIV-1 integrase inhibitors.

H. M. Langford, D. Hazuda, W. Schleif, 2008, Bioorganic & medicinal chemistry letters.

Combinatorial library of indinavir analogues: replacement for the aminoindanol at P2'.

L. Kuo, W. Schleif, L. Gabryelski, 2002, Bioorganic & medicinal chemistry letters.

Combinatorial diversification of indinavir: in vivo mixture dosing of an HIV protease inhibitor library.

L. Kuo, W. Schleif, L. Gabryelski, 2000, Bioorganic & medicinal chemistry letters.

Design and synthesis of 8-hydroxy-[1,6]naphthyridines as novel inhibitors of HIV-1 integrase in vitro and in infected cells.

Linghang Zhuang, D. Hazuda, W. Schleif, 2003, Journal of medicinal chemistry.

Indinavir analogues with blocked metabolism sites as HIV protease inhibitors with improved pharmacological profiles and high potency against PI-resistant viral strains.

Yuan Cheng, Jiunn H. Lin, W. Schleif, 2002, Bioorganic & medicinal chemistry letters.

4-Aryl-2,4-dioxobutanoic acid inhibitors of HIV-1 integrase and viral replication in cells.

H. M. Langford, D. Hazuda, W. Schleif, 2000, Journal of medicinal chemistry.

A series of 5-(5,6)-dihydrouracil substituted 8-hydroxy-[1,6]naphthyridine-7-carboxylic acid 4-fluorobenzylamide inhibitors of HIV-1 integrase and viral replication in cells.

D. Hazuda, Jiunn H. Lin, W. Schleif, 2005, Bioorganic & medicinal chemistry letters.

Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells.

J A Grobler, Amy S. Espeseth, D. Hazuda, 2000, Science.

Novel indole-3-sulfonamides as potent HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs).

G. McGaughey, Youwei Yan, L. Gabryelski, 2008, Bioorganic & medicinal chemistry letters.

Orally bioavailable highly potent HIV protease inhibitors against PI-resistant virus.

Jiunn H. Lin, W. Schleif, L. Gabryelski, 2005, Bioorganic & medicinal chemistry letters.

Synthesis of 5-(1-H or 1-alkyl-5-oxopyrrolidin-3-yl)-8-hydroxy-[1,6]-naphthyridine-7-carboxamide inhibitors of HIV-1 integrase.

D. Hazuda, W. Schleif, L. Gabryelski, 2008, Bioorganic & medicinal chemistry letters.

Vectored Gag and Env but Not Tat Show Efficacy against Simian-Human Immunodeficiency Virus 89.6P Challenge in Mamu-A*01-Negative Rhesus Monkeys

J. Shiver, W. Schleif, L. Gabryelski, 2005, Journal of Virology.

A series of 5-aminosubstituted 4-fluorobenzyl-8-hydroxy-[1,6]naphthyridine-7-carboxamide HIV-1 integrase inhibitors.

D. Hazuda, W. Schleif, L. Gabryelski, 2006, Bioorganic & medicinal chemistry letters.

10-Hydroxy-7,8-dihydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-1,9(2H,6H)-diones: potent, orally bioavailable HIV-1 integrase strand-transfer inhibitors with activity against integrase mutants.

D. Hazuda, W. Schleif, L. Gabryelski, 2008, Bioorganic & medicinal chemistry letters.

Design and synthesis of highly potent HIV protease inhibitors with activity against resistant virus.

W. Schleif, L. Gabryelski, E. Emini, 2003, Bioorganic & medicinal chemistry letters.

Synthesis of novel HIV protease inhibitors (PI) with activity against PI-resistant virus.

W. Schleif, L. Gabryelski, E. Emini, 2007, Bioorganic & medicinal chemistry letters.

8-Hydroxy-3,4-dihydropyrrolo[1,2-a]pyrazine-1(2H)-one HIV-1 integrase inhibitors.

D. Hazuda, W. Schleif, L. Gabryelski, 2007, Bioorganic & medicinal chemistry letters.

Dihydroxypyridopyrazine-1,6-dione HIV-1 integrase inhibitors.

D. Hazuda, W. Schleif, L. Gabryelski, 2007, Bioorganic & medicinal chemistry letters.