Eugene M. Johnson

发表

Suppression of programmed neuronal death by sustained elevation of cytoplasmic calcium

J. Franklin, Eugene M. Johnson, E. Johnson, 1992, Trends in Neurosciences.

Artemin Is a Vascular-Derived Neurotropic Factor for Developing Sympathetic Neurons

J. Milbrandt, Eugene M. Johnson, A. Bruce, 2002, Neuron.

NGF augments the autophosphorylation of Ret via inhibition of ubiquitin‐dependent degradation

J. Milbrandt, Eugene M. Johnson, E. Johnson, 2007, Journal of neurochemistry.

Properly scaled and targeted AAV2-NRTN (neurturin) to the substantia nigra is safe, effective and causes no weight loss: Support for nigral targeting in Parkinson's disease

Eugene M. Johnson, J. Kordower, R. Bartus, 2011, Neurobiology of Disease.

Alternating metabolic pathways in NGF-deprived sympathetic neurons affect caspase-independent death

R. Schmidt, Eugene M. Johnson, Louis K. Chang, 2003, The Journal of cell biology.

GFRα1-Deficient Mice Have Deficits in the Enteric Nervous System and Kidneys

J. Milbrandt, Eugene M. Johnson, W. Snider, 1998, Neuron.

GFRα-Mediated Localization of RET to Lipid Rafts Is Required for Effective Downstream Signaling, Differentiation, and Neuronal Survival

J. Milbrandt, Eugene M. Johnson, M. Tansey, 2000, Neuron.

Gene Targeting Reveals a Critical Role for Neurturin in the Development and Maintenance of Enteric, Sensory, and Parasympathetic Neurons

J. Milbrandt, Eugene M. Johnson, W. Snider, 1999, Neuron.

The activation loop phosphorylation of protein kinase D is an early marker of neuronal DNA damage

Eugene M. Johnson, E. Johnson, C. Besirli, 2006, Journal of neurochemistry.

Critical and distinct roles for key RET tyrosine docking sites in renal development.

J. Milbrandt, Eugene M. Johnson, Sanjay Jain, 2006, Genes & development.

Neurturin-Mediated Ret Activation Is Required for Retinal Function

J. Milbrandt, Eugene M. Johnson, M. Brantley, 2008, The Journal of Neuroscience.

Mice expressing a dominant-negative Ret mutation phenocopy human Hirschsprung disease and delineate a direct role of Ret in spermatogenesis

J. Milbrandt, C. Naughton, Eugene M. Johnson, 2004, Development.

GFRα1 Expression in Cells Lacking RET Is Dispensable for Organogenesis and Nerve Regeneration

J. Milbrandt, Eugene M. Johnson, H. Enomoto, 2004, Neuron.

Persephin, a Novel Neurotrophic Factor Related to GDNF and Neurturin

R. Vejsada, C. Henderson, J. Milbrandt, 1998, Neuron.

Inhibition of Apoptotic Signaling Cascades Causes Loss of Trophic Factor Dependence during Neuronal Maturation

Eugene M. Johnson, M. Deshmukh, G. Putcha, 2000, The Journal of cell biology.

Fibroblast growth factor receptor‐bearing neurons in the CNS: Identification by receptor‐mediated retrograde transport

Eugene M. Johnson, I. Ferguson, E. Johnson, 1991, The Journal of comparative neurology.

Nomenclature of GPI-Linked Receptors for the GDNF Ligand Family

L. M. Goodman, J. Treanor, J. Milbrandt, 1997, Neuron.

Artemin, a Novel Member of the GDNF Ligand Family, Supports Peripheral and Central Neurons and Signals through the GFRα3–RET Receptor Complex

J. Milbrandt, Eugene M. Johnson, H. Enomoto, 1998, Neuron.

Control of Neuronal Size Homeostasis by Trophic Factor–mediated Coupling of Protein Degradation to Protein Synthesis

J. Franklin, Eugene M. Johnson, E. Johnson, 1998, The Journal of cell biology.

Functional Mapping of Receptor Specificity Domains of Glial Cell Line-derived Neurotrophic Factor (GDNF) Family Ligands and Production of GFRα1 RET-specific Agonists*

J. Milbrandt, Eugene M. Johnson, M. Tansey, 2000, The Journal of Biological Chemistry.

Effect of capsaicin upon fluoride sensitive acid phosphatases in selected ganglia and spinal cord and upon neuronal size and number in dorsal root ganglion

Sarah H. McDougal, Eugene M. Johnson, D. McDougal, 1985, Brain Research.

Glial Cell Line-Derived Neurotrophic Factor Promotes the Survival of Early Postnatal Spinal Motor Neurons in the Lateral and Medial Motor Columns in Slice Culture

J. Milbrandt, Eugene M. Johnson, W. Rakowicz, 2002, The Journal of Neuroscience.

Central nervous system and peripheral nerve growth factor provide trophic support critical to mature sensory neuronal survival

Eugene M. Johnson, H. Yip, E. Johnson, 1985, Nature.

The Long and Short Isoforms of Ret Function as Independent Signaling Complexes*

R. Crowder, J. Milbrandt, Eugene M. Johnson, 2002, The Journal of Biological Chemistry.

Expression of Neurturin, GDNF, and GDNF Family-Receptor mRNA in the Developing and Mature Mouse

J. Milbrandt, Eugene M. Johnson, J. Demaro, 1999, Experimental Neurology.

Analysis of Events Leading to Neuronal Death after Infection with E1-Deficient Adenoviral Vectors

Eugene M. Johnson, D. Creedon, R. Easton, 1998, Molecular and Cellular Neuroscience.

Postnatal development of survival responsiveness in rat sympathetic neurons to leukemia inhibitory factor and ciliary neurotrophic factor

J. Milbrandt, S. Estus, Eugene M. Johnson, 1994, Neuron.

Cyclosporin A inhibits caspase-independent death of NGF-deprived sympathetic neurons

Eugene M. Johnson, Louis K. Chang, E. Johnson, 2002, The Journal of cell biology.

The limited role of NH2-terminal c-Jun phosphorylation in neuronal apoptosis

E. Wagner, Eugene M. Johnson, C. Besirli, 2005, The Journal of cell biology.

The limited role of NH2-terminal c-Jun phosphorylation in neuronal apoptosis

E. Wagner, Eugene M. Johnson, C. Besirli, 2005, The Journal of cell biology.

Why do neurons die when deprived of trophic factor?

D. P. Martin, Eugene M. Johnson, T. Koike, 1989, Neurobiology of Aging.

Models of chemotherapy drug-induced peripheral neuropathy

Eugene M. Johnson, J. Golden, E. Johnson, 2004 .

Ventral rhizotomy enhances regeneration of uninjured sensory neurons

Eugene M. Johnson, K. Rich, E. Johnson, 1985, Brain Research.

Immunosuppressive agents prevent guanethidine-induced destruction of rat sympathetic neurons

Eugene M. Johnson, J. Russell, P. Manning, 1982, Brain Research.

Presenilin-1 Protects against Neuronal Apoptosis Caused by Its Interacting Protein PAG

A. Goate, Jane Y. Wu, Eugene M. Johnson, 2002, Neurobiology of Disease.

Caspase Inhibition Extends the Commitment to Neuronal Death Beyond Cytochrome c Release to the Point of Mitochondrial Depolarization

Eugene M. Johnson, K. Kuida, M. Deshmukh, 2000, The Journal of cell biology.

Effect of exposure to anti-NGF on sensory neurons of adult rats and guinea pigs

Eugene M. Johnson, J. P. Schwartz, J. Pearson, 1982, Brain Research.

Destruction of the sympathetic nervous system in neonatal rats and hamsters by vinblastine: prevention by concomitant administration of nerve growth factor

Eugene M. Johnson, E. Johnson, 1978, Brain Research.

Neurotrophin and GDNF family ligands promote survival and alter excitotoxic vulnerability of neurons derived from murine embryonic stem cells

D. Gottlieb, Eugene M. Johnson, D. Choi, 2005, Experimental Neurology.

Expression and possible function of nerve growth factor receptors on Schwann cells

P. Distefano, Eugene M. Johnson, M. Taniuchi, 1988, Trends in Neurosciences.

Disruption of the Jak1 Gene Demonstrates Obligatory and Nonredundant Roles of the Jaks in Cytokine-Induced Biologic Responses

R. Schreiber, Eugene M. Johnson, S. Rodig, 1998, Cell.

Placement of the BCL2 Family Member BAX in the Death Pathway of Sympathetic Neurons Activated by Trophic Factor Deprivation

S. Korsmeyer, Eugene M. Johnson, C. Knudson, 1998, Experimental Neurology.

The GDNF family ligands and receptors — implications for neural development

Hideki Enomoto, J. Milbrandt, Eugene M. Johnson, 2000, Current Opinion in Neurobiology.

Intrinsic and extrinsic pathway signaling during neuronal apoptosis

Charles A. Harris, K. Moulder, Eugene M. Johnson, 2002, The Journal of cell biology.

Induction of BIM, a Proapoptotic BH3-Only BCL-2 Family Member, Is Critical for Neuronal Apoptosis

K. Moulder, A. Strasser, Eugene M. Johnson, 2001, Neuron.

BAX Is Required for Neuronal Death after Trophic Factor Deprivation and during Development

S. Korsmeyer, Eugene M. Johnson, W. Snider, 1996, Neuron.

Role of BCL-2 in the survival and function of developing and mature sympathetic neurons

S. Korsmeyer, Eugene M. Johnson, L. Greenlund, 1995, Neuron.

Superoxide dismutase delays neuronal apoptosis: A role for reactive oxygen species in programmed neuronal death

Eugene M. Johnson, T. Deckwerth, L. Greenlund, 1995, Neuron.

Molecular genetics of neuronal survival

Eugene M. Johnson, W. Snider, L. Greenlund, 1995, Current Opinion in Neurobiology.

Bax Deletion Further Orders the Cell Death Pathway in Cerebellar Granule Cells and Suggests a Caspase-independent Pathway to Cell Death

S. Korsmeyer, K. Moulder, Eugene M. Johnson, 1997, The Journal of cell biology.

BAX Translocation Is a Critical Event in Neuronal Apoptosis: Regulation by Neuroprotectants, BCL-2, and Caspases

Eugene M. Johnson, M. Deshmukh, G. Putcha, 1999, The Journal of Neuroscience.

Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis

S. Estus, Eugene M. Johnson, R. Bravo, 1994, The Journal of cell biology.

Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury.

A. Shah, D. Holtzman, M. Jacquin, 1998, The Journal of clinical investigation.

JNK-Mediated BIM Phosphorylation Potentiates BAX-Dependent Apoptosis

Eugene M. Johnson, S. Frank, A. Maroney, 2003, Neuron.

Clinical tests of neurotrophic factors for human neurodegenerative diseases, part 2: Where do we stand and where must we go next?

Eugene M. Johnson, R. Bartus, E. Johnson, 2017, Neurobiology of Disease.

Clinical tests of neurotrophic factors for human neurodegenerative diseases, part 1: Where have we been and what have we learned?

Eugene M. Johnson, R. Bartus, E. Johnson, 2017, Neurobiology of Disease.

BH3-only Bcl-2 family members are coordinately regulated by the JNK pathway and require Bax to induce apoptosis in neurons.

Charles A. Harris, Eugene M. Johnson, E. Johnson, 2001, The Journal of biological chemistry.

Analysis of cell cycle-related gene expression in postmitotic neurons: Selective induction of cyclin D1 during programmed cell death

S. Estus, Eugene M. Johnson, R. Freeman, 1994, Neuron.

Mixed-lineage kinases: a target for the prevention of neurodegeneration.

Eugene M. Johnson, Eugene M Johnson, Leo H Wang, 2004, Annual review of pharmacology and toxicology.

Localization of FGF receptor mRNA in the adult rat central nervous system by in situ hybridization

Eugene M. Johnson, A. Wanaka, E. Johnson, 1990, Neuron.

MIXED LINEAGE KINASE INHIBITOR CEP- 1347 FAILS TO DELAY DISABILITY IN EARLY PARKINSON DISEASE

Eugene M. Johnson, Eugene M Johnson, Leo H Wang, 2008, Neurology.

Protection from guanethidine-induced neuronal destruction by nerve growth factor: Effect of NGF on immune function

Eugene M. Johnson, J. Russell, P. Manning, 1985, Brain Research.

Evidence of a Novel Event during Neuronal Death Development of Competence-to-Die in Response to Cytoplasmic Cytochrome c

Eugene M. Johnson, M. Deshmukh, E. Johnson, 1998, Neuron.

Events that Commit Neurons to Die After Trophic Factor Deprivation

Eugene M. Johnson, M. Deshmukh, G. Putcha, 2001 .

Chronic guanethidine treatment increases cardiac β-adrenergic receptors

R. Lefkowitz, Eugene M. Johnson, B. Weiss, 1978, Nature.

Neurotoxicity of MAO metabolites of catecholamine neurotransmitters: role in neurodegenerative diseases.

D. S. Zahm, W. Burke, Eugene M. Johnson, 2004, Neurotoxicology.

Lipid rafts in neuronal signaling and function

J. Milbrandt, Eugene M. Johnson, M. Encinas, 2002, Trends in Neurosciences.

RET Is Dispensable for Maintenance of Midbrain Dopaminergic Neurons in Adult Mice

Judith P Golden, J. Milbrandt, E. Pehek, 2006, The Journal of Neuroscience.

JNK-independent Activation of c-Jun during Neuronal Apoptosis Induced by Multiple DNA-damaging Agents*

Eugene M. Johnson, C. Besirli, E. Johnson, 2003, Journal of Biological Chemistry.

4 – NEUROTROPHIC FACTORS

M. Tuszynski, Eugene M. Johnson, E. Johnson, 2008 .

Neurturin, a relative of glial-cell-line-derived neurotrophic factor

J. Milbrandt, Eugene M. Johnson, R. Heuckeroth, 1996, Nature.

RET Signaling Is Required for Survival and Normal Function of Nonpeptidergic Nociceptors

Robert W Gereau, Hideki Enomoto, Masato Hoshi, 2010, The Journal of Neuroscience.

Characterization of the retrograde transport of nerve growth factor (NGF) using high specific activity [125I]NGF

Eugene M. Johnson, R. Bradshaw, R. Andres, 1978, Brain Research.

Expression of FGF receptor gene in rat development.

J. Milbrandt, Eugene M. Johnson, A. Wanaka, 1991, Development.

Chronic depolarization prevents programmed death of sympathetic neurons in vitro but does not support growth: requirement for Ca2+ influx but not Trk activation

J. Franklin, Eugene M. Johnson, A. Juhász, 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Effects of long-term nerve growth factor deprivation on the nervous system of the adult rat: An experimental autoimmune approach

Eugene M. Johnson, P. D. Gorin, E. Johnson, 1980, Brain Research.

Development and Maintenance of Renal Hypertension in Normal and Guanethidine Sympathectomized Rats

B. K. Hartman, G. Marshall, Eugene M. Johnson, 1975, Circulation research.

Mixed-Lineage Kinase Inhibitors Require the Activation of Trk Receptors to Maintain Long-Term Neuronal Trophism and Survival

Eugene M. Johnson, Leo H. Wang, E. Johnson, 2005, Journal of Pharmacology and Experimental Therapeutics.

Inhibition of the c-Jun N-Terminal Kinase Signaling Pathway by the Mixed Lineage Kinase Inhibitor CEP-1347 (KT7515) Preserves Metabolism and Growth of Trophic Factor-Deprived Neurons

Charles A. Harris, Eugene M. Johnson, A. Maroney, 2002, The Journal of Neuroscience.

Genetic and metabolic status of NGF-deprived sympathetic neurons saved by an inhibitor of ICE family proteases

Eugene M. Johnson, T. Deckwerth, M. Deshmukh, 1996, The Journal of cell biology.

The role of NGF in sensory neurons in vivo

Eugene M. Johnson, H. Yip, K. Rich, 1986, Trends in Neurosciences.

TrnR2, a Novel Receptor That Mediates Neurturin and GDNF Signaling through Ret

J. Milbrandt, Eugene M. Johnson, D. Zimonjic, 1997, Neuron.

NGF Utilizes c-Ret Via a Novel GFL-Independent, Inter-RTK Signaling Mechanism to Maintain the Trophic Status of Mature Sympathetic Neurons

J. Milbrandt, Eugene M. Johnson, B. Tsui-Pierchala, 2002, Neuron.

TGFβ Trophic Factors Differentially Modulate Motor Axon Outgrowth and Protection from Excitotoxicity

J. Milbrandt, J. Rothstein, Eugene M. Johnson, 2000, Experimental Neurology.

Dopamine-Dependent Compensation Maintains Motor Behavior in Mice with Developmental Ablation of Dopaminergic Neurons

Robert W Gereau, Masato Hoshi, Judith P Golden, 2013, The Journal of Neuroscience.

The limited role of NH 2 -terminal c-Jun phosphorylation in neuronal apoptosis: Identiﬁcation of the nuclear pore complex as a potential target of the JNK pathway

E. Wagner, Eugene M. Johnson, C. Besirli, 2005 .

Retrograde transport of nerve growth factor (NGF) in motoneurons of developing rats: Assessment of potential neurotrophic effects

Eugene M. Johnson, W. Snider, J. Pinzone, 1988, Neuron.

Tyrosine 981, a Novel Ret Autophosphorylation Site, Binds c-Src to Mediate Neuronal Survival*

R. Crowder, J. Milbrandt, Eugene M. Johnson, 2004, Journal of Biological Chemistry.

Dok-6, a Novel p62 Dok Family Member, Promotes Ret-mediated Neurite Outgrowth*

R. Crowder, J. Milbrandt, Eugene M. Johnson, 2004, Journal of Biological Chemistry.

Glial Cell Line-Derived Neurotrophic Factor-Dependent Recruitment of Ret into Lipid Rafts Enhances Signaling by Partitioning Ret from Proteasome-Dependent Degradation

J. Milbrandt, Eugene M. Johnson, B. Pierchala, 2006, The Journal of Neuroscience.

Nerve Growth Factor Promotes the Survival of Sympathetic Neurons through the Cooperative Function of the Protein Kinase C and Phosphatidylinositol 3-Kinase Pathways*

Eugene M. Johnson, B. Pierchala, Rebecca Ahrens, 2004, Journal of Biological Chemistry.

Effects of exposure to nerve growth factor antibodies on the developing nervous system of the rat: an experimental autoimmune approach.

Eugene M. Johnson, E. Johnson, P. D. Gorin, 1980, Developmental biology.

In situ immunodetection of neuronal caspase-3 activation in Alzheimer disease.

D. Holtzman, D. Holtzman, Eugene M. Johnson, 1999, Journal of neuropathology and experimental neurology.

Exogenous Smac Induces Competence and Permits Caspase Activation in Sympathetic Neurons

Xiaodong Wang, Eugene M. Johnson, M. Deshmukh, 2002, The Journal of Neuroscience.

Reversible Physiological Alterations in Sympathetic Neurons Deprived of NGF but Protected from Apoptosis by Caspase Inhibition or Bax Deletion

J. Werth, Eugene M. Johnson, S. Rothman, 2000, Experimental Neurology.

Identification of JNK‐dependent and ‐independent components of cerebellar granule neuron apoptosis

Charles A. Harris, Eugene M. Johnson, A. Maroney, 2002, Journal of neurochemistry.

GFRα3 is an orphan member of the GDNF/neurturin/persephin receptor family

J. Milbrandt, Eugene M. Johnson, C. Keck, 1998 .

Time and dose dependencies of effects of nerve growth factor on sympathetic and sensory neurons in neonatal rats

Eugene M. Johnson, H. Kornblum, E. Johnson, 1982, Brain Research.

NGF deprivation and neuronal degeneration trigger altered beta-amyloid precursor protein gene expression in the rat superior cervical ganglia in vivo and in vitro.

Eugene M. Johnson, P. Brachet, R. Freeman, 1993, Brain research. Molecular brain research.

Catecholamine-Derived Aldehyde Neurotoxins

D. S. Zahm, W. Burke, Eugene M. Johnson, 2000 .

Partial purification of a parasympathetic neurotrophic factor in pig lung

Eugene M. Johnson, T. Wallace, E. Johnson, 1987, Brain Research.

Reduction by reserpine of the accumulation of retrogradely transported [125I]nerve growth factor in sympathetic neurons

Eugene M. Johnson, R. Bradshaw, H. Blumberg, 1979, Brain Research.

Cell death genes in invertebrates and (maybe) vertebrates

S. Estus, Eugene M. Johnson, R. Freeman, 1993, Current Opinion in Neurobiology.

Destruction of sympathetic and sensory neurons in the developing rat by a monoclonal antibody against the nerve growth factor (NGF) receptor

Eugene M. Johnson, P. Osborne, M. Taniuchi, 1989, Brain Research.

Multiple Channel Interactions Explain the Protection of Sympathetic Neurons from Apoptosis Induced by Nerve Growth Factor Deprivation

Eugene M. Johnson, S. Yu, S. Xia, 2002, The Journal of Neuroscience.

Effects of autoimmune NGF deprivation in the adult rabbit and offspring

Eugene M. Johnson, R. Rydel, J. Pearson, 1982, Brain Research.

Suppression of Active Neuronal Death by Immune Interferon

Eugene M. Johnson, Jason Y. Chang, B. Levy, 1989 .

Phosphatidylinositol 3-Kinase Is Required for the Trophic, But Not the Survival-Promoting, Actions of NGF on Sympathetic Neurons

Eugene M. Johnson, G. Putcha, E. Johnson, 2000, The Journal of Neuroscience.

A “calcium set-point hypothesis” of neuronal dependence on neurotrophic factor

J. Franklin, Eugene M. Johnson, T. Koike, 1992, Experimental Neurology.

Protection from guanethidine-induced neuronal destruction by nerve growth factor: Effect of NGF on immune function

Eugene M. Johnson, J. Russell, P. Manning, 1985, Brain Research.

Alzheimer research forum live discussion: mice on trial? Issues in the design of drug studies.

J. Glass, S. Perrin, B. Barres, 2009, Journal of Alzheimer's disease : JAD.

Cyclosporin A inhibits caspase-independent death of NGF-deprived sympathetic neurons

Eugene M. Johnson, Louis K. Chang, 2002, The Journal of cell biology.

Behavioral effects of early deprivation of nerve growth factor: Some similarities with familial dysautonomia

S. Finger, Eugene M. Johnson, J. Bell, 1982, Brain Research.