J. Klein-Nulend

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Pulsatile fluid flow stimulates nitric oxide (NO) production by osteocytes, but not periosteal fibroblasts

J. Klein-Nulend, E. Burger, C. Semeins, 1995 .

3D-printed poly(Ɛ-caprolactone) scaffold with gradient mechanical properties according to force distribution in the mandible for mandibular bone tissue engineering.

J. H. Koolstra, J. Klein-Nulend, M. Helder, 2020, Journal of the mechanical behavior of biomedical materials.

MECHANOTRANSDUCTION IN BONE : ROLE OF THE LACUNOCANALICULAR NETWORK

J. Klein-Nulend, E. Burger, J. Klein‐Nulend, 1999 .

Mechanotransduction of bone cellsin vitro: Mechanobiology of bone tissue

M. Mullender, J. Klein-Nulend, E. Burger, 2006, Medical and Biological Engineering and Computing.

Mechanisms of Osteocyte Mechanotransduction

J. Klein-Nulend, A. Bakker, 2010 .

Mechanosensation and transduction in osteocytes.

S. Weinbaum, R. Bacabac, J. Klein-Nulend, 2013, Bone.

Pulsating fluid flow increases nitric oxide (NO) synthesis by osteocytes but not periosteal fibroblasts--correlation with prostaglandin upregulation.

P. Nijweide, J. Klein-Nulend, E. Burger, 1995, Biochemical and biophysical research communications.

Sensitivity of osteocytes to biomechanical stress in vitro

A. van der Plas, P. Nijweide, J. Klein-Nulend, 1995, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Mechanotransduction in Bone

S. Cowin, J. Klein-Nulend, E. Burger, 1998 .

Osteocyte morphology in fibula and calvaria --- is there a role for mechanosensing?

T. Smit, J. Klein-Nulend, C. Semeins, 2008, Bone.

Aging, Osteocytes, and Mechanotransduction

J. Klein-Nulend, G. V. van Lenthe, A. Bakker, 2017, Current Osteoporosis Reports.

A novel approach revealing the effect of a collagenous membrane on osteoconduction in maxillary sinus floor elevation with β-tricalcium phosphate.

J. Klein-Nulend, M. Helder, H. Prins, 2013, European cells & materials.

Pulsating fluid flow increases prostaglandin production by cultured chicken osteocytes--a cytoskeleton-dependent process.

E H Burger, P. Nijweide, J. Klein-Nulend, 1996, Biochemical and biophysical research communications.

Expression of Serotonin Receptors in Bone*

A. van der Plas, P. Nijweide, J. Klein-Nulend, 2001, The Journal of Biological Chemistry.

Modulation of osteogenesis in fetal bone rudiments by mechanical stress in vitro.

J. Klein-Nulend, E. Burger, J. Veldhuijzen, 1991, Journal of biomechanics.

Wnt signaling is involved in human articular chondrocyte de-differentiation in vitro

J. Klein-Nulend, B. Zandieh-Doulabi, S. Makni, 2014, Biotechnic & histochemistry : official publication of the Biological Stain Commission.

The roles of canonical and non-canonical Wnt signaling in human de-differentiated articular chondrocytes

J. Klein-Nulend, B. Zandieh-Doulabi, S. Makni, 2014, Biotechnic & histochemistry : official publication of the Biological Stain Commission.

Biologically Relevant In Vitro 3D-Model to Study Bone Regeneration Potential of Human Adipose Stem Cells

J. Klein-Nulend, A. Bakker, Victor J. B. van Santen, 2022, Biomolecules.

CXCL8 and CCL20 Enhance Osteoclastogenesis via Modulation of Cytokine Production by Human Primary Osteoblasts

W. Lems, F. Luyten, J. Klein-Nulend, 2015, PloS one.

Increased Endoplasmic Reticulum Stress in Mouse Osteocytes with Aging Alters Cox-2 Response to Mechanical Stimuli

J. Klein-Nulend, L. Deldicque, R. Jaspers, 2014, Calcified Tissue International.

Hypothermia reduces VEGF-165 expression, but not osteogenic differentiation of human adipose stem cells under hypoxia

J. Klein-Nulend, A. Bakker, P. Nolte, 2017, PloS one.

Different responsiveness to mechanical stress of bone cells from osteoporotic versus osteoarthritic donors

I. Heyligers, P. Lips, J. Klein-Nulend, 2006, Osteoporosis International.

Serum of patients with active rheumatoid arthritis inhibits differentiation of osteochondrogenic precursor cells

W. Lems, F. Luyten, J. Klein-Nulend, 2016, Connective tissue research.

The Osteocyte as an Orchestrator of Bone Remodeling: An Engineer’s Perspective

R. Bacabac, J. Klein-Nulend, R. V. Oers, 2014, Clinical Reviews in Bone and Mineral Metabolism.

Strontium ranelate affects signaling from mechanically-stimulated osteocytes towards osteoclasts and osteoblasts.

J. Klein-Nulend, B. Zandieh-Doulabi, A. Bakker, 2013, Bone.

Diet and Exercise: a Match Made in Bone

J. Klein-Nulend, R. Schoemaker, A. Bakker, 2017, Current Osteoporosis Reports.

Mechanical Stimulation and IGF‐1 Enhance mRNA Translation Rate in Osteoblasts Via Activation of the AKT‐mTOR Pathway

J. Klein-Nulend, R. Jaspers, A. Bakker, 2016, Journal of cellular physiology.

Mechanical Loading Stimulates BMP7, But Not BMP2, Production by Osteocytes

J. Klein-Nulend, A. Bakker, A. Bronckers, 2011, Calcified Tissue International.

Stiff matrices enhance myoblast proliferation, reduce differentiation, and alter the response to fluid shear stress in vitro

J. Klein-Nulend, R. Jaspers, A. Bakker, 2022, Cell biochemistry and biophysics.

VDR dependent and independent effects of 1,25-dihydroxyvitamin D3 on nitric oxide production by osteoblasts

J. Klein-Nulend, G. Carmeliet, A. Bakker, 2012, Steroids.

Is There a Governing Role of Osteocytes in Bone Tissue Regeneration?

J. Klein-Nulend, M. Helder, Gang Wu, 2020, Current Osteoporosis Reports.

Inhibition by 17 beta-estradiol of PTH stimulated resorption and prostaglandin production in cultured neonatal mouse calvariae.

J. Klein-Nulend, L. Raisz, C. Pilbeam, 1989, Biochemical and biophysical research communications.

J. Klein-Nulend, L. Deldicque, Nicolas Pierre, 2015, Biochemical and biophysical research communications.

Low‐intensity ultrasound stimulates endochondral ossification in vitro

R. Marti, J. Klein-Nulend, E. Burger, 2001, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

A Three-Dimensional Mechanical Loading Model of Human Osteocytes in Their Native Matrix

H. V. van Essen, J. Klein-Nulend, N. Bravenboer, 2021, Calcified tissue international.

Mechanical Loading Differentially Affects Osteocytes in Fibulae from Lactating Mice Compared to Osteocytes in Virgin Mice: Possible Role for Lacuna Size

J. Klein-Nulend, C. Semeins, G. V. van Lenthe, 2018, Calcified Tissue International.

Accuracy and reproducibility of mouse cortical bone microporosity as quantified by desktop microcomputed tomography

J. Klein-Nulend, G. V. van Lenthe, D. Vanderschueren, 2017, PloS one.

Osteogenesis versus chondrogenesis by BMP-2 and BMP-7 in adipose stem cells.

J. Klein-Nulend, M. Helder, B. Zandieh Doulabi, 2006, Biochemical and biophysical research communications.

CHAPTER 7 POLYAMINES REGULATE RUNX-2 AND OSTEOPONTIN GENE EXPRESSION , AND ALKALINE PHOSPHATASE ACTIVITY IN ADIPOSE TISSUE-DERIVED MESENCHYMAL STEM CELLS

J. Klein-Nulend, M. Helder, B. Zandieh-Doulabi, 2011 .

The polymine spermine regulates osteogenic differentiation in adipose stem cells

J. Klein-Nulend, M. Helder, P. Wuisman, 2008, Journal of cellular and molecular medicine.

Prostaglandins differentially affect osteogenic differentiation of human adipose tissue-derived mesenchymal stem cells.

J. Klein-Nulend, P. Wuisman, M. Helder, 2007, Tissue engineering.

Osteogenic protein (OP-1, BMP-7) stimulates cartilage differentiation of human and goat perichondrium tissue in vitro.

I. Heyligers, J. Klein-Nulend, E. Burger, 1998, Journal of biomedical materials research.

Influence of nanostructural environment and fluid flow on osteoblast-like cell behavior: a model for cell-mechanics studies.

J. Jansen, J. Klein-Nulend, C. Semeins, 2013, Acta biomaterialia.

Collaboration Around Rare Bone Diseases Leads to the Unique Organizational Incentive of the Amsterdam Bone Center

W. Lems, G. Pals, A. Lammertsma, 2020, Frontiers in Endocrinology.

Fluid shear stress-induced mechanotransduction in myoblasts: Does it depend on the glycocalyx?

J. Klein-Nulend, L. Deldicque, R. Jaspers, 2022, Experimental cell research.

CHAPTER 3 Cytokines TNF-α , IL-6 , IL-17 F , and IL-4 differentially affect osteogenic differentiation of human adipose stem cells

J. Klein-Nulend, B. Zandieh-Doulabi, T. Forouzanfar, 2019 .

Cytokines TNF-α, IL-6, IL-17F, and IL-4 Differentially Affect Osteogenic Differentiation of Human Adipose Stem Cells

J. Klein-Nulend, B. Zandieh-Doulabi, T. Forouzanfar, 2016, Stem cells international.

Exostoses of the Bony Pyramid of the Nose: A Review About an Adaptive Response to Mechanical Stimuli Exerted by In-Flight Oxygen Masks

M. Kon, J. Klein-Nulend, P. Nolte, 2015, Clinical Reviews in Bone and Mineral Metabolism.

Mechanical loading prevents the stimulating effect of IL-1β on osteocyte-modulated osteoclastogenesis.

J. Klein-Nulend, V. Everts, A. Bakker, 2012, Biochemical and biophysical research communications.

MT1-MMP modulates the mechanosensitivity of osteocytes.

J. Klein-Nulend, V. Everts, A. Bakker, 2012, Biochemical and biophysical research communications.

Mechanically Loaded Myotubes Affect Osteoclast Formation

J. Klein-Nulend, R. Jaspers, A. Bakker, 2014, Calcified Tissue International.

CHAPTER 3 Mechanical loading induces expression of osteo-anabolic and osteo-catabolic factors by myotubes : Role in myogenic adaptation

J. Klein-Nulend, R. Jaspers, A. Bakker, 2013 .

Incorporation of anterior iliac crest or calvarial bone grafts in reconstructed atrophied maxillae: A randomized clinical trial with histomorphometric and micro‐CT analyses

A. Vissink, J. Klein-Nulend, G. Raghoebar, 2021, Clinical implant dentistry and related research.

Histomorphometric and micro‐CT analyses of calvarial bone grafts used to reconstruct the extremely atrophied maxilla

A. Vissink, J. Klein-Nulend, G. Raghoebar, 2020, Clinical implant dentistry and related research.

Blood Vessel Formation and Bone Regeneration Potential of the Stromal Vascular Fraction Seeded on a Calcium Phosphate Scaffold in the Human Maxillary Sinus Floor Elevation Model

J. Klein-Nulend, M. Helder, E. Schulten, 2018, Materials.

Evaluation of a new biphasic calcium phosphate for maxillary sinus floor elevation: Micro‐CT and histomorphometrical analyses

J. Klein-Nulend, M. Helder, E. Schulten, 2018, Clinical oral implants research.

A histomorphometric and micro-computed tomography study of bone regeneration in the maxillary sinus comparing biphasic calcium phosphate and deproteinized cancellous bovine bone in a human split-mouth model.

G. Langenbach, J. Klein-Nulend, G. D. de Lange, 2014, Oral surgery, oral medicine, oral pathology and oral radiology.

Reaming debris as a novel source of autologous bone to enhance healing of bone defects.

R. D. de Kleine, J. Klein-Nulend, R. Kroeze, 2011, Journal of biomedical materials research. Part A.

Inflammatory factors in the circulation of patients with active rheumatoid arthritis stimulate osteoclastogenesis via endogenous cytokine production by osteoblasts

W. Lems, F. Luyten, J. Klein-Nulend, 2014, Osteoporosis International.

Clinical Correlate : Van Buchem Disease

J. Klein-Nulend, A. Bronckers, H. Prins, 2013 .

Osteoblast isolation from murine calvaria and long bones.

J. Klein-Nulend, A. Bakker, J. Klein‐Nulend, 2012, Methods in molecular biology.

Systemic Inflammation Affects Human Osteocyte-Specific Protein and Cytokine Expression

W. Lems, F. Luyten, J. Klein-Nulend, 2016, Calcified Tissue International.

Polymethyl methacrylate does not adversely affect the osteogenic potential of human adipose stem cells or primary osteoblasts

J. Klein-Nulend, T. Forouzanfar, A. Bakker, 2019, Journal of biomedical materials research. Part B, Applied biomaterials.

Effect of 1,25‐dihydroxyvitamin D3 on prostaglandin E2 production in cultured mouse parietal bones

J. Klein-Nulend, L. Raisz, C. Pilbeam, 1991, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

PLS3 mutations in X-linked osteoporosis with fractures

A. Hofman, A. Uitterlinden, B. Wirth, 2014 .

The Src Inhibitor AZD0530 Reversibly Inhibits the Formation and Activity of Human Osteoclasts

M. Mullender, J. Klein-Nulend, C. Semeins, 2009, Molecular Cancer Research.

Bone vitality and vascularization of mandibular and maxillary bone grafts in maxillary sinus floor elevation: A retrospective cohort study

J. Klein-Nulend, M. Helder, V. Wu, 2022, Clinical implant dentistry and related research.

Bone cells from patients with quiescent Crohn's disease show a reduced growth potential and an impeded maturation

W. Lems, H. V. van Essen, P. Lips, 2012, Journal of cellular biochemistry.

Buccal fat pad, an oral access source of human adipose stem cells with potential for osteochondral tissue engineering: an in vitro study.

J. Klein-Nulend, Elisabet Farré-Guasch, N. Casals, 2010, Tissue engineering. Part C, Methods.

Additive effects of estrogen and mechanical stress on nitric oxide and prostaglandin E2 production by bone cells from osteoporotic donors

P. Lips, J. Klein-Nulend, E. Burger, 2005, Osteoporosis International.

Response of periodontal ligament fibroblasts and gingival fibroblasts to pulsating fluid flow: nitric oxide and prostaglandin E2 release and expression of tissue non-specific alkaline phosphatase activity.

J. Klein-Nulend, E. Burger, V. Everts, 2000, Journal of periodontal research.

Enhanced osteogenic activity by MC3T3-E1 pre-osteoblasts on chemically surface-modified poly(ε-caprolactone) 3D-printed scaffolds compared to RGD immobilized scaffolds

J. Klein-Nulend, M. Helder, Y. Zamani, 2018, Biomedical materials.

The osteocyte

J. Klein-Nulend, J. Klein‐Nulend, L. F. Bonewald, 2020, Principles of Bone Biology.

Role of osteocytes in the adaptation of bone to mechanical loading

J. Klein-Nulend, A. Bakker, J. Klein‐Nulend, 2008 .

Chapter 8 – The Osteocyte

L. Bonewald, J. Klein-Nulend, J. Klein‐Nulend, 2008 .

Osteocytes: Mechanosensors of Bone and Orchestrators of Mechanical Adaptation

Jenneke Klein-Nulend, J. Klein-Nulend, A. Bakker, 2007 .

Response of normal and osteoporotic human bone cells to mechanical stress in vitro.

P. Lips, J. Klein-Nulend, E. Burger, 1998, American journal of physiology. Endocrinology and metabolism.

Bone cell mechanosensitivity, estrogen deficiency, and osteoporosis.

Jenneke Klein-Nulend, R. Bacabac, J. Klein-Nulend, 2015, Journal of biomechanics.

Effect of cyclic uni-axial strain on IGF-I Ea and MGF gene expression by osteoblasts and osteocytes

P. Lips, J. Klein-Nulend, R. Jaspers, 2013 .

Osteocyte morphology in human tibiae of different bone pathologies with different bone mineral density--is there a role for mechanosensing?

Theo H Smit, Jenneke Klein-Nulend, T. Smit, 2009, Bone.

Strain-derived canalicular fluid flow regulates osteoclast activity in a remodelling osteon--a proposal.

Theo H Smit, Elisabeth H Burger, Jenneke Klein-Nulend, 2003, Journal of biomechanics.

Expression of muscle anabolic and metabolic factors in mechanically loaded MLO-Y4 osteocytes.

P. Lips, J. Klein-Nulend, R. Jaspers, 2012, American journal of physiology. Endocrinology and metabolism.

Pulsating fluid flow modulates gene expression of proteins involved in Wnt signaling pathways in osteocytes

J. Klein-Nulend, C. Semeins, B. Zandieh-Doulabi, 2009, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Nitric oxide production by bone cells is fluid shear stress rate dependent.

Theo H Smit, Jenneke Klein-Nulend, M. Mullender, 2004, Biochemical and biophysical research communications.

Responses of Bone Cells to Biomechanical Forces in Vitro

J. Klein-Nulend, E. Burger, J. Klein‐Nulend, 1999, Advances in dental research.

Dynamic shear stress in parallel-plate flow chambers.

Theo H Smit, Jenneke Klein-Nulend, Stephen C Cowin, 2005, Journal of biomechanics.

Low-intensity pulsed ultrasound affects human articular chondrocytes in vitro

C. M. Korstjens, G. H. R. Albers, R. H. H. van der Rijt, 2008, Medical & Biological Engineering & Computing.

Round versus flat: bone cell morphology, elasticity, and mechanosensing.

Daisuke Mizuno, Theo H Smit, Christoph F Schmidt, 2008, Journal of biomechanics.

Cellulose and its derivatives: towards biomedical applications

R. Bacabac, J. Klein-Nulend, Lester C. Geonzon, 2021, Cellulose.

Donor Age and Mechanosensitivity of Human Bone Cells

J. A. Baart, C. M. Semeins, J. Klein-Nulend, 2002, Osteoporosis International.

Response of normal and osteoporotic human bone cells to mechanical stress in vitro.

P. Lips, J. Klein-Nulend, E. Burger, 1998, The American journal of physiology.

Adipose tissue-derived mesenchymal stem cell yield and growth characteristics are affected by the tissue-harvesting procedure.

F J van Milligen, J. Klein-Nulend, M. Helder, 2006, Cytotherapy.

Mechanoresponsiveness of human adipose stem cells on nanocomposite and micro-hybrid composite.

J. Klein-Nulend, C. Semeins, B. Zandieh-Doulabi, 2017, Journal of biomedical materials research. Part A.

The role of osteocytes in bone mechanotransduction

A. D. Bakker, J. Klein-Nulend, J. Klein-Nulend, 2009, Osteoporosis International.

Mechanical stimulation by intermittent hydrostatic compression promotes bone-specific gene expression in vitro.

E H Burger, J. Klein-Nulend, E. Burger, 1995, Journal of biomechanics.

Enhanced Osteogenic and Vasculogenic Differentiation Potential of Human Adipose Stem Cells on Biphasic Calcium Phosphate Scaffolds in Fibrin Gels

J. Klein-Nulend, B. Zandieh-Doulabi, C. Kleverlaan, 2016, Stem cells international.

Stem cells from adipose tissue allow challenging new concepts for regenerative medicine.

J. Klein-Nulend, M. Helder, P. Wuisman, 2007, Tissue engineering.

Hypoxia decreases osteogenic differentiation potential but enhances vasculogenic differentiation potential of human adipose stem cells on biphasic calcium phosphate scaffolds in fibrin gels

J. Klein-Nulend, P. Koolwijk, J. Klein‐Nulend, 2017 .

Use of recombinant human osteogenic protein-1 for the repair of subchondral defects in articular cartilage in goats.

I. Heyligers, J. Klein-Nulend, E. Burger, 2000, Journal of biomedical materials research.

Polyamines Modulate Nitric Oxide Production and Cox‐2 Gene Expression in Response to Mechanical Loading in Human Adipose Tissue‐Derived Mesenchymal Stem Cells

J. Klein-Nulend, M. Helder, B. Zandieh-Doulabi, 2006, Stem cells.

Mechanobiology of bone tissue.

M G Mullender, M. Mullender, R. Bacabac, 2005, Pathologie-biologie.

Microgravity and bone cell mechanosensitivity.

R. Bacabac, J. Klein-Nulend, J Klein-Nulend, 2003, Advances in space research : the official journal of the Committee on Space Research.

Microgravity and bone cell mechanosensitivity.

E H Burger, J. Klein-Nulend, E. Burger, 1998, Bone.

Biocompatibility of Polypyrrole with Human Primary Osteoblasts and the Effect of Dopants

J. Klein-Nulend, C. Semeins, A. Gelmi, 2015, PloS one.

Transforming growth factor-β1 incorporated during setting in calcium phosphate cement stimulates bone cell differentiation in vitro

J. Klein-Nulend, E. Burger, C. Klein, 2000 .

Increased Endoplasmic Reticulum Stress in Mouse Osteocytes with Aging Alters Cox-2 Response to Mechanical Stimuli

J. Klein-Nulend, L. Deldicque, R. Jaspers, 2015, Calcified Tissue International.

The Osteocyte as the New Discovery of Therapeutic Options in Rare Bone Diseases

J. Klein-Nulend, J. Pathak, N. Bravenboer, 2020, Frontiers in Endocrinology.

Pulsating Fluid Flow Stimulates Prostaglandin Release and Inducible Prostaglandin G/H Synthase mRNA Expression in Primary Mouse Bone Cells

E H Burger, J. Klein-Nulend, E. Burger, 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Mechanical loading stimulates the release of transforming growth factor‐β activity by cultured mouse calvariae and periosteal cells

E H Burger, J. Klein-Nulend, E. Burger, 1995, Journal of cellular physiology.

UvA-DARE ( Digital Academic Repository ) Mechanical loading and how it affects bone cells : the role of the osteocyte cytoskeleton in maintaining our skeleton

R. Bacabac, J. Klein-Nulend, A. Bakker, 2017 .

Osteopontin-deficient bone cells are defective in their ability to produce NO in response to pulsatile fluid flow.

J. Klein-Nulend, E. Burger, C. Semeins, 2001, Biochemical and biophysical research communications.

Increased bone formation and decreased bone resorption in fetal mouse calvaria as a result of intermittent compressive force in vitro.

J. Klein-Nulend, M. de Jong, J. Veldhuijzen, 1987, Bone and mineral.

Mechanical stimulation of osteopontin mRNA expression and synthesis in bone cell cultures

J. Klein-Nulend, E. Burger, C. Semeins, 1997, Journal of cellular physiology.

IL‐6 counteracts the inhibitory effect of IL‐4 on osteogenic differentiation of human adipose stem cells

J. Klein-Nulend, P. Koolwijk, T. Forouzanfar, 2019, Journal of cellular physiology.

Application of Additive Manufacturing in Oral and Maxillofacial Surgery.

Jan Wolff, Jenneke Klein-Nulend, Elisabet Farré-Guasch, 2015, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

Human maxillary sinus floor elevation as a model for bone regeneration enabling the application of one-step surgical procedures.

J. Klein-Nulend, M. Helder, H. Prins, 2013, Tissue engineering. Part B, Reviews.

Differences in Osteocyte Density and Bone Histomorphometry Between Men and Women and Between Healthy and Osteoporotic Subjects

L. Vico, M. G. Mullender, J. Klein-Nulend, 2005, Calcified Tissue International.

Increased calcification of growth plate cartilage as a result of compressive force in vitro.

E H Burger, J. Klein-Nulend, E. Burger, 1986, Arthritis and rheumatism.

Bioprinting of Alginate-Encapsulated Pre-osteoblasts in PLGA/β-TCP Scaffolds Enhances Cell Retention but Impairs Osteogenic Differentiation Compared to Cell Seeding after 3D-Printing

J. Klein-Nulend, M. Helder, Y. Zamani, 2020, Regenerative Engineering and Translational Medicine.

Nitric Oxide is Involved in the Down-regulation of SOST Expression Induced by Mechanical Loading

J. Klein-Nulend, J. Riancho, J. Delgado-Calle, 2014, Calcified Tissue International.

1,25‐Dihydroxyvitamin D3—mediated transforming growth factor‐β release is impaired in cultured osteoblasts from patients with multiple pituitary hormone deficiencies

P. Lips, J. Klein-Nulend, E. Burger, 1996 .

Physicochemical Niche Conditions and Mechanosensing by Osteocytes and Myocytes

J. Klein-Nulend, R. Jaspers, A. Bakker, 2019, Current Osteoporosis Reports.

Inhibition of osteocyte apoptosis by fluid flow is mediated by nitric oxide.

A. Kuijpers-Jagtman, J. Klein-Nulend, C. Semeins, 2008, Biochemical and biophysical research communications.

Early activation of the beta-catenin pathway in osteocytes is mediated by nitric oxide, phosphatidyl inositol-3 kinase/Akt, and focal adhesion kinase.

Jenneke Klein-Nulend, Behrouz Zandieh-Doulabi, J. Klein-Nulend, 2010, Biochemical and biophysical research communications.

Studies on Osteocytes in Their 3D Native Matrix Versus 2D In Vitro Models

J. Klein-Nulend, A. Bakker, N. Bravenboer, 2019, Current Osteoporosis Reports.

Systemic Inflammation Affects Human Osteocyte-Specific Protein and Cytokine Expression

W. Lems, F. Luyten, J. Klein-Nulend, 2016, Calcified Tissue International.

Transforming growth factor-beta1 incorporated in calcium phosphate cement stimulates osteotransductivity in rat calvarial bone defects.

J. Klein-Nulend, E. Burger, L. Yin, 2001, Clinical oral implants research.

Osteocytes subjected to fluid flow inhibit osteoclast formation and bone resorption.

Anne Marie Kuijpers-Jagtman, Jenneke Klein-Nulend, Vincent Everts, 2007, Bone.

Osteocytes subjected to pulsating fluid flow regulate osteoblast proliferation and differentiation.

Jenneke Klein-Nulend, Qian Chen, J. Klein-Nulend, 2006, Biochemical and biophysical research communications.

Differential stimulation of prostaglandin G/H synthase-2 in osteocytes and other osteogenic cells by pulsating fluid flow.

E H Burger, P. Nijweide, J. Klein-Nulend, 2000, Biochemical and biophysical research communications.

Fluid Shear Stress Inhibits TNFα-induced Osteocyte Apoptosis

J. Klein-Nulend, A. Kuijpers-Jagtman, J. Klein-Nulend, 2006, Journal of dental research.

Supraphysiological loading induces osteocyte‐mediated osteoclastogenesis in a novel in vitro model for bone implant loosening

J. Klein-Nulend, C. Semeins, A. Bakker, 2018, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Inhibition of Osteoclastogenesis by Mechanically Loaded Osteocytes: Involvement of MEPE

Jenneke Klein-Nulend, Vincent Everts, J. Klein-Nulend, 2010, Calcified Tissue International.

Mapping the Response of Human Osteocytes in Native Matrix to Mechanical Loading Using RNA Sequencing

H. V. van Essen, J. Klein-Nulend, D. Micha, 2023, JBMR plus.

Stimulation of bone cell differentiation by low‐intensity ultrasound—a histomorphometric in vitro study

E H Burger, J. Klein-Nulend, E. Burger, 2004, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Transforming growth factor-β1 incorporation in an α-tricalcium phosphate/dicalcium phosphate dihydrate/ tetracalcium phosphate monoxide cement: release characteristics and physicochemical properties

Jenneke Klein-Nulend, J. Klein-Nulend, E. Burger, 2002 .

Nitric oxide signaling in mechanical adaptation of bone

R. Bacabac, J. Klein-Nulend, A. Bakker, 2013, Osteoporosis International.

Bio Imaging of Intracellular NO Production in Single Bone Cells After Mechanical Stimulation

Daisuke Mizuno, Theo H Smit, Christoph F Schmidt, 2006, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Signal transduction pathways involved in fluid flow-induced PGE2 production by cultured osteocytes.

E H Burger, P. Nijweide, J. Klein-Nulend, 1999, American journal of physiology. Endocrinology and metabolism.

Differences in proliferation, differentiation, and cytokine production by bone cells seeded on titanium–nitride and cobalt–chromium–molybdenum surfaces

J. Klein-Nulend, C. Semeins, P. Nolte, 2013, Journal of biomaterials applications.

A comparison of strain and fluid shear stress in stimulating bone cell responses—a computational and experimental study

Jenneke Klein-Nulend, J. McGarry, P. Prendergast, 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Estrogen enhances mechanical stress-induced prostaglandin production by bone cells from elderly women.

I. Heyligers, J. Klein-Nulend, E. Burger, 2001, American journal of physiology. Endocrinology and metabolism.

Predictive value of femoral head heterogeneity for fracture risk.

B. van Rietbergen, J. Klein-Nulend, E. Tanck, 2009, Bone.

Bone Tissue Regeneration in the Oral and Maxillofacial Region: A Review on the Application of Stem Cells and New Strategies to Improve Vascularization

J. Klein-Nulend, M. Helder, V. Wu, 2019, Stem cells international.

Bone Regeneration Using the Freshly Isolated Autologous Stromal Vascular Fraction of Adipose Tissue in Combination With Calcium Phosphate Ceramics

J. Klein-Nulend, M. Helder, H. Prins, 2016, Stem cells translational medicine.

Correlation of clinical manifestations and condylar morphology of patients with temporomandibular degenerative joint diseases.

J. Klein-Nulend, A. Bakker, J. Pathak, 2022, Cranio : the journal of craniomandibular practice.

UvA-DARE ( Digital Academic Repository ) CXCL 8 and CCL 20 enhance osteoclastogenesis via modulation of cytokine production by human primary osteoblasts

W. Lems, F. Luyten, J. Klein-Nulend, 2015 .

K-Carrageenan Stimulates Pre-Osteoblast Proliferation and Osteogenic Differentiation: A Potential Factor for the Promotion of Bone Regeneration?

R. Bacabac, J. Klein-Nulend, S. Matsukawa, 2021, Molecules.

CHAPTER 2 THE ROLE OF OSTEOCYTES IN BONE MECHANOTRANSDUCTION

Hogervorst, J. Klein-Nulend, B. Zandieh-Doulabi, 2010 .

The 3D Printing of Calcium Phosphate with K-Carrageenan under Conditions Permitting the Incorporation of Biological Components—A Method

Jenneke Klein-Nulend, J. Klein-Nulend, D. Wismeijer, 2018, Journal of functional biomaterials.

Release of nitric oxide, but not prostaglandin E2, by bone cells depends on fluid flow frequency

M. Mullender, R. Bacabac, J. Klein-Nulend, 2006, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Shear stress inhibits while disuse promotes osteocyte apoptosis.

Jenneke Klein-Nulend, J. Klein-Nulend, E. Burger, 2004, Biochemical and biophysical research communications.

Increased Osteogenic Potential of Pre-Osteoblasts on Three-Dimensional Printed Scaffolds Compared to Porous Scaffolds for Bone Regeneration.

J. Klein-Nulend, M. Helder, Y. Zamani, 2021, Iranian biomedical journal.

Prostaglandin mediated modulation of transforming growth factor‐β metabolism in primary mouse osteoblastic cells in vitro

J. Klein-Nulend, E. Burger, C. Semeins, 1996, Journal of cellular physiology.

Mechanism of regulation of prostaglandin production by parathyroid hormone, interleukin-1, and cortisol in cultured mouse parietal bones.

J. Klein-Nulend, L. Raisz, C. Pilbeam, 1991, Endocrinology.

Endothelial Nitric Oxide Synthase is Not Essential for Nitric Oxide Production by Osteoblasts Subjected to Fluid Shear Stress In Vitro

R. Aspden, A. Hughes, J. Klein-Nulend, 2013, Calcified Tissue International.

Natural and recombinant human IL-1 receptor antagonists block the effects of IL-1 on bone resorption and prostaglandin production.

J. Klein-Nulend, R. Thompson, J. Dayer, 1990, Journal of immunology.

J. Klein-Nulend, G. V. van Lenthe, D. Vanderschueren, 2018, Bone.

WNT5A induces osteogenic differentiation of human adipose stem cells via rho-associated kinase ROCK.

Jenneke Klein-Nulend, J. Klein-Nulend, A. Bakker, 2010, Cytotherapy.

Osteocyte and bone structure

Elisabeth H. Burger, Jenneke Klein-Nulend, P. Nijweide, 2003, Current osteoporosis reports.

Mechanical stress induces COX-2 mRNA expression in bone cells from elderly women.

J. Klein-Nulend, E. Burger, C. Semeins, 2000, Journal of biomechanics.

Mechanotransduction in bone cells proceeds via activation of COX-2, but not COX-1.

E H Burger, J. Klein-Nulend, E. Burger, 2003, Biochemical and biophysical research communications.

Isolation of primary avian osteocytes.

J. Klein-Nulend, C. Semeins, A. Bakker, 2012, Methods in molecular biology.

Osteocyte isolation and culture.

A. van der Plas, P. Nijweide, J. Klein-Nulend, 2003, Methods in molecular medicine.

Microscale fluid flow analysis in a human osteocyte canaliculus using a realistic high-resolution image-based three-dimensional model.

Yoshitaka Kameo, Taiji Adachi, Akio Takaoka, 2012, Integrative biology : quantitative biosciences from nano to macro.

Mechanical Loading Differentially Affects Osteocytes in Fibulae from Lactating Mice Compared to Osteocytes in Virgin Mice: Possible Role for Lacuna Size

J. Klein-Nulend, C. Semeins, G. V. van Lenthe, 2018, Calcified Tissue International.

Inlet flow rate of perfusion bioreactors affects fluid flow dynamics, but not oxygen concentration in 3D-printed scaffolds for bone tissue engineering: Computational analysis and experimental validation

Jenneke Klein-Nulend, Ghassem Amoabediny, Hadi Seddiqi, 2020, Comput. Biol. Medicine.

Tumor necrosis factor alpha and interleukin-1beta modulate calcium and nitric oxide signaling in mechanically stimulated osteocytes.

R. Bacabac, J. Klein-Nulend, R. Krishnan, 2009, Arthritis and rheumatism.

Shear Stress Modulates Osteoblast Cell and Nucleus Morphology and Volume

J. Korfage, J. Klein-Nulend, R. Jaspers, 2020, International Journal of Molecular Sciences.

Transforming growth factor-beta1 incorporated during setting in calcium phosphate cement stimulates bone cell differentiation in vitro.

J. Klein-Nulend, E. Burger, C. Klein, 2000, Journal of biomedical materials research.

The production of nitric oxide and prostaglandin E(2) by primary bone cells is shear stress dependent.

E H Burger, J. Klein-Nulend, E. Burger, 2001, Journal of biomechanics.

Function of osteocytes in bone--their role in mechanotransduction.

E H Burger, A. van der Plas, P. Nijweide, 1995, The Journal of nutrition.

Microgravity and bone cell mechanosensitivity: FLOW experiment during the DELTA mission

J. Loon, R. Bacabac, T. Smit, 2007 .

Inhibition of osteoclastic bone resorption by mechanical stimulation in vitro.

E H Burger, J. Klein-Nulend, E. Burger, 1990, Arthritis and rheumatism.

PLS3 mutations in X-linked osteoporosis with fractures.

A. Hofman, A. Uitterlinden, B. Wirth, 2013, The New England journal of medicine.

Osteoblast isolation from murine calvariae and long bones.

J. Klein-Nulend, A. Bakker, J. Klein‐Nulend, 2003, Methods in molecular medicine.

Sulfated carboxymethyl cellulose and carboxymethyl κ-carrageenan immobilization on 3D-printed poly-ε-caprolactone scaffolds differentially promote pre-osteoblast proliferation and osteogenic activity

R. Bacabac, J. Klein-Nulend, Hadi Seddiqi, 2022, Frontiers in Bioengineering and Biotechnology.

Biomimetic 3D-printed PCL scaffold containing a high concentration carbonated-nanohydroxyapatite with immobilized-collagen for bone tissue engineering: enhanced bioactivity and physicomechanical characteristics

J. Klein-Nulend, Hadi Seddiqi, N. Najmoddin, 2021, Biomedical materials.

Growth factor gene expression profiles of bone morphogenetic protein-2-treated human adipose stem cells seeded on calcium phosphate scaffolds in vitro.

J. Klein-Nulend, M. Helder, A. Bakker, 2013, Biochimie.

Kappa-carrageenan-Functionalization of octacalcium phosphate-coated titanium Discs enhances pre-osteoblast behavior and osteogenic differentiation

R. Bacabac, J. Klein-Nulend, M. Helder, 2022, Frontiers in Bioengineering and Biotechnology.

Transforming growth factor-beta1 incorporation in a calcium phosphate bone cement: material properties and release characteristics.

J. Klein-Nulend, E. Burger, F. Driessens, 2002, Journal of biomedical materials research.

The effect of cytoskeletal disruption on pulsatile fluid flow-induced nitric oxide and prostaglandin E2 release in osteocytes and osteoblasts.

J. McGarry, P. Prendergast, J. Klein-Nulend, 2005, Biochemical and biophysical research communications.

Detection of living cells in non-processed but deep-frozen bone allografts

I. Heyligers, J. Klein-Nulend, J. Klein‐Nulend, 2005, Cell and Tissue Banking.

Alterations in osteocyte lacunar morphology affect local bone tissue strains.

J. Klein-Nulend, G. V. van Lenthe, A. Bakker, 2021, Journal of the mechanical behavior of biomedical materials.

Osteocyte morphology and orientation in relation to strain in the jaw bone

R. Bacabac, J. Klein-Nulend, M. Helder, 2018, International Journal of Oral Science.

Mechanical stress and osteogenesis in vitro

E H Burger, J. Klein-Nulend, E. Burger, 1992, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Mechanical Loading by Fluid Shear Stress of Myotube Glycocalyx Stimulates Growth Factor Expression and Nitric Oxide Production

J. Klein-Nulend, R. Jaspers, A. Bakker, 2014, Cell Biochemistry and Biophysics.

Noise enhances the rapid nitric oxide production by bone cells in response to fluid shear stress.

R. Bacabac, T. Smit, J. Klein-Nulend, 2009, Technology and health care : official journal of the European Society for Engineering and Medicine.

Initial Stress-Kick Is Required for Fluid Shear Stress-Induced Rate Dependent Activation of Bone Cells

J. Loon, M. Mullender, R. Bacabac, 2005, Annals of Biomedical Engineering.

Effects of two inhibitors of anion transport on bone resorption in organ culture.

J. Klein-Nulend, L. Raisz, J. Klein‐Nulend, 1989, Endocrinology.

Bone cell responses to high‐frequency vibration stress: does the nucleus oscillate within the cytoplasm?

Theo H Smit, Jenneke Klein-Nulend, R. Bacabac, 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Human dental pulp cells exhibit bone cell-like responsiveness to fluid shear stress.

B. Melsen, J. Klein-Nulend, D. Kraft, 2011, Cytotherapy.

Mechanosensitivity of dental pulp stem cells is related to their osteogenic maturity.

B. Melsen, J. Klein-Nulend, M. Kassem, 2010, European journal of oral sciences.

Differential effects of bone morphogenetic protein-2 and transforming growth factor-beta1 on gene expression of collagen-modifying enzymes in human adipose tissue-derived mesenchymal stem cells.

J. Klein-Nulend, R. Bank, M. Helder, 2009, Tissue engineering. Part A.

Pulsating fluid flow affects pre‐osteoblast behavior and osteogenic differentiation through production of soluble factors

J. Korfage, J. Klein-Nulend, R. Jaspers, 2021, Physiological reports.

Paxillin localisation in osteocytes--is it determined by the direction of loading?

T. Smit, J. Klein-Nulend, C. Semeins, 2008, Biochemical and biophysical research communications.

Reduced growth rate of aged muscle stem cells is associated with impaired mechanosensitivity

J. Klein-Nulend, L. Deldicque, R. Jaspers, 2022, Aging.

Effects and regulation of prostaglandins in bone: Possible implications for the pathogenesis of osteoporosis

J. Klein-Nulend, L. Raisz, C. Pilbeam, 1991, Journal of Bone and Mineral Metabolism.

Fibrin network adaptation to cell-generated forces

R. Bacabac, J. Klein-Nulend, F. V. Esterik, 2018, Rheologica Acta.

Adipose tissue-derived mesenchymal stem cells acquire bone cell-like responsiveness to fluid shear stress on osteogenic stimulation.

Jenneke Klein-Nulend, Marco N Helder, J. Klein-Nulend, 2005, Tissue engineering.

Low-intensity pulsed ultrasound affects RUNX2 immunopositive osteogenic cells in delayed clinical fracture healing.

J. Klein-Nulend, P. Nolte, C. Korstjens, 2009, Bone.

Stimulation of cartilage differentiation by osteogenic protein-1 in cultures of human perichondrium.

J. Klein-Nulend, E. Burger, C. Semeins, 1998, Tissue engineering.

Low-intensity pulsed ultrasound increases bone volume, osteoid thickness and mineral apposition rate in the area of fracture healing in patients with a delayed union of the osteotomized fibula.

Jenneke Klein-Nulend, J. Klein-Nulend, Peter A Nolte, 2008, Bone.

Short (15 minutes) bone morphogenetic protein-2 treatment stimulates osteogenic differentiation of human adipose stem cells seeded on calcium phosphate scaffolds in vitro.

J. Klein-Nulend, M. Helder, E. Schulten, 2013, Tissue engineering. Part A.

Short Pretreatment with Calcitriol Is Far Superior to Continuous Treatment in Stimulating Proliferation and Osteogenic Differentiation of Human Adipose Stem Cells

J. Klein-Nulend, M. Helder, G. Amoabediny, 2019, Cell journal.

Signal transduction pathways involved in fluid flow-induced PGE2 production by cultured osteocytes.

P. Nijweide, J. Klein-Nulend, E. Burger, 1999, The American journal of physiology.

Bone Adaptation and Regeneration - New Developments

R. Bacabac, J. Klein-Nulend, 2012 .

Effect of mechanical stimulation on the production of soluble bone factors in cultured fetal mouse calvariae

J. Veldhuijzen, J. Klein-Nulend, E. Burger, 1993, Cell and Tissue Research.

Influence of intermittent compressive force on proteoglycan content in calcifying growth plate cartilage in vitro.

J. Klein-Nulend, R. Kuijer, J. Veldhuijzen, 1987, The Journal of biological chemistry.

Comparison of the effects of synthetic human parathyroid hormone (PTH)-(1-34)-related peptide of malignancy and bovine PTH-(1-34) on bone formation and resorption in organ culture.

J. Klein-Nulend, L. Raisz, P. Fall, 1990, Endocrinology.

' s personal copy Osteocytes subjected to fluid flow inhibit osteoclast formation and bone resorption

A. Kuijpers-Jagtman, J. Klein-Nulend, V. Everts, 2007 .

Extracellular NO signalling from a mechanically stimulated osteocyte.

T. Smit, J. Klein-Nulend, A. Vatsa, 2007, Journal of biomechanics.

Interactive effects of PTH and mechanical stress on nitric oxide and PGE2 production by primary mouse osteoblastic cells.

Elisabeth H Burger, Jenneke Klein-Nulend, J. Klein-Nulend, 2003, American journal of physiology. Endocrinology and metabolism.

The novel endolysin XZ.700 effectively treats MRSA biofilms in two biofilm models without showing toxicity on human bone cells in vitro

J. Klein-Nulend, B. P. Krom, A. Bakker, 2021, Biofouling.

Orthodontic Force Stimulates eNOS and iNOS in Rat Osteocytes

A. Kuijpers-Jagtman, J. Klein-Nulend, J. W. Von den Hoff, 2009, Journal of dental research.

Different responsiveness of cells from adult and neonatal mouse bone to mechanical and biochemical challenge

J. Klein-Nulend, E. Burger, C. Semeins, 2001, Journal of cellular physiology.

Noise enhances the production by bone shear stress oxide

R. Bacabac, J. Klein-Nulend, Thea H. SmitC, 2009 .

Mechanosensitivity of aged muscle stem cells

J. Klein-Nulend, R. Jaspers, A. Bakker, 2017, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Characteristics of the parallel-plate flow chamber for mechanical stimulation of bone cells under microgravity.

R. Heethaar, R. Bacabac, T. Smit, 2002, Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology.

Stiff matrices enhance myoblast proliferation, reduce differentiation, and alter the response to fluid shear stress in vitro

J. Klein-Nulend, R. Jaspers, A. Bakker, 2022, Cell Biochemistry and Biophysics.

IL-6 Alters Osteocyte Signaling toward Osteoblasts but Not Osteoclasts

J. Klein-Nulend, A. Bakker, J Klein-Nulend, 2014, Journal of dental research.

Rgd-Functionalized Supported Lipid Bilayers Modulate Pre-Osteoblast Adherence and Promote Osteogenic Differentiation.

J. Klein-Nulend, R. Jaspers, P. Jonkheijm, 2020, Journal of biomedical materials research. Part A.

Surface modification of silicone tubes by functional carboxyl and amine, but not peroxide groups followed by collagen immobilization improves endothelial cell stability and functionality

J. Klein-Nulend, N. Salehi-Nik, M. Shokrgozar, 2015, Biomedical materials.

Immediate dental implant placement in calvarial bone grafts to rehabilitate the severely resorbed edentulous maxilla: A prospective pilot study.

A. Vissink, J. Klein-Nulend, G. Raghoebar, 2019, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.

Myofiber stretch induces tensile and shear deformation of muscle stem cells in their native niche

J. Klein-Nulend, R. Jaspers, A. Bakker, 2020, bioRxiv.

Identification of an osteoblastic silencer element in the first intron of the rat osteocalcin gene.

J. Klein-Nulend, H. Kronenberg, M. Demay, 1996, Biochemistry.

Long-Term Safety of Bone Regeneration Using Autologous Stromal Vascular Fraction and Calcium Phosphate Ceramics: A 10-Year Prospective Cohort Study

J. Klein-Nulend, M. Helder, V. Wu, 2023, Stem cells translational medicine.

Influence of Oxygen in the Cultivation of Human Mesenchymal Stem Cells in Simulated Microgravity: An Explorative Study

J. Klein-Nulend, S. Bradamante, S. Versari, 2012, Microgravity, science and technology.

Endothelial Nitric Oxide Synthase is Not Essential for Nitric Oxide Production by Osteoblasts Subjected to Fluid Shear Stress In Vitro

Jenneke Klein-Nulend, Richard M. Aspden, R. Aspden, 2012, Calcified Tissue International.

Nitric oxide response to shear stress by human bone cell cultures is endothelial nitric oxide synthase dependent.

E H Burger, J. Klein-Nulend, E. Burger, 1998, Biochemical and biophysical research communications.

Evidence that adenosine 3',5'-monophosphate mediates hormonal stimulation of prostaglandin production in cultured mouse parietal bones.

J. Klein-Nulend, L. Raisz, P. Bowers, 1990, Endocrinology.

Transforming growth factor-beta1 incorporation in an alpha-tricalcium phosphate/dicalcium phosphate dihydrate/tetracalcium phosphate monoxide cement: release characteristics and physicochemical properties.

J. Klein-Nulend, E. Burger, J. Wolke, 2002, Biomaterials.

J. Klein-Nulend, D. Vanderschueren, M. Laurent, 2018, Bone.

Mechanosensation and transduction in osteocytes.

S. Weinbaum, R. Bacabac, J. Klein-Nulend, 2013, Bone.

MT1-MMP modulates the mechanosensitivity of osteocytes.

J. Klein-Nulend, V. Everts, A. Bakker, 2012, Biochemical and biophysical research communications.

Expression of muscle anabolic and metabolic factors in mechanically loaded MLO-Y4 osteocytes.

P. Lips, J. Klein-Nulend, R. Jaspers, 2012, American journal of physiology. Endocrinology and metabolism.

Biomimetic modification of silicone tubes using sodium nitrite-collagen immobilization accelerates endothelialization.

J. Klein-Nulend, N. Salehi-Nik, M. Shokrgozar, 2016, Journal of biomedical materials research. Part B, Applied biomaterials.

The role of osteocytes in bone mechanotransduction

R. Bacabac, J. Klein-Nulend, A. Vatsa, 2005 .

1,25-dihydroxyvitamin D3-mediated transforming growth factor-beta release is impaired in cultured osteoblasts from patients with multiple pituitary hormone deficiencies.

P. Lips, J. Klein-Nulend, E. Burger, 1996, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Microgravity and bone cell mechanosensitivity.

J. Klein-Nulend, E. H. Burger, 1998, Bone.

Nitric Oxide is Involved in the Down-regulation of SOST Expression Induced by Mechanical Loading

Jenneke Klein-Nulend, J. Klein-Nulend, J. Riancho, 2013, Calcified Tissue International.

Fluoride inhibits the response of bone cells to mechanical loading

J. Klein-Nulend, A. Bakker, A. Bronckers, 2011, Odontology.

Pulsating fluid flow modulates gene expression of proteins involved in Wnt signaling pathways in osteocytes

J. Klein-Nulend, C. Semeins, B. Zandieh-Doulabi, 2009, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

PLS3 mutations in X-linked osteoporosis with fractures.

B. Wirth, G. Pals, Q. Waisfisz, 2013, The New England journal of medicine.

Predictive value of femoral head heterogeneity for fracture risk.

J. Klein-Nulend, V. Rietbergen, A. Bakker, 2009, Bone.