R. Cherny

发表

Strategies for the isolation and characterization of bovine embryonic stem cells.

R. Cherny, T. M. Stokes, J. Merei, 1994, Reproduction, fertility, and development.

Plasma amyloid beta42 and amyloid beta40 levels are associated with early cognitive dysfunction after cardiac surgery.

C. Masters, P. Maruff, R. Cherny, 2009, The Annals of thoracic surgery.

Copper and zinc binding modulates the aggregation and neurotoxic properties of the prion peptide PrP106-126.

A. Bush, R. Cherny, R. Cappai, 2001, Biochemistry.

Parkinson's Disease Iron Deposition Caused by Nitric Oxide-Induced Loss of β-Amyloid Precursor Protein

A. Bush, R. Cherny, P. Adlard, 2015, The Journal of Neuroscience.

Genetic or Pharmacological Iron Chelation Prevents MPTP-Induced Neurotoxicity In Vivo A Novel Therapy for Parkinson's Disease

Subramanian Rajagopalan, Russell Jacobs, Ashley I Bush, 2003, Neuron.

Copper and Alzheimer Disease: The Good, the Bad and the Ugly

A. Bush, R. Cherny, Ya Hui Hung, 2012 .

Elevated cortical zinc in Alzheimer disease

V. Haroutunian, J. Naslund, V. Haroutunian, 2006, Neurology.

Metals, Oxidative Stress, and Brain Biology

A. Bush, R. Cherny, D. Finkelstein, 2007 .

The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson’s disease

C. Masters, A. Bush, R. Cherny, 2017, Acta neuropathologica communications.

The effect of dopamine on MPTP-induced rotarod disability

A. Bush, R. Cherny, P. Adlard, 2013, Neuroscience Letters.

Quantitative elemental bio-imaging of Mn, Fe, Cu and Zn in 6-hydroxydopamine induced Parkinsonism mouse models

Philip Doble, Rudolf Grimm, Dominic J. Hare, 2009 .

Elevated labile Cu is associated with oxidative pathology in Alzheimer disease.

C. Masters, A. Bush, R. Cherny, 2012, Free radical biology & medicine.

Direct in vivo imaging of ferrous iron dyshomeostasis in ageing Caenorhabditis elegans

Blaine R. Roberts, M. D. de Jonge, A. Bush, 2015, Chemical science.

Hypoxia-inducible Factor Prolyl 4-Hydroxylase Inhibition

J. LaManna, J. Connor, A. Bush, 2005, Journal of Biological Chemistry.

Intracellular Accumulation of Detergent‐Soluble Amyloidogenic Aβ Fragment of Alzheimer's Disease Precursor Protein in the Hippocampus of Aged Transgenic Mice

C. Masters, A. Bush, R. Cherny, 1999, Journal of neurochemistry.

Iron inhibits neurotoxicity induced by trace copper and biological reductants

Xudong Huang, Colin L. Masters, Ashley I. Bush, 2004, JBIC Journal of Biological Inorganic Chemistry.

Investigating copper‐regulated protein expression in Menkes fibroblasts using antibody microarrays

C. Masters, A. Bush, R. Cherny, 2008, Proteomics.

Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).

Xudong Huang, Colin L Masters, Roberto Cappai, 2002, The Journal of biological chemistry.

Metal-Protein Attenuation With Iodochlorhydroxyquin (Clioquinol) Targeting A Amyloid Deposition and Toxicity in Alzheimer Disease

A. Mackinnon, C. Masters, R. Tanzi, 2003 .

Cytosolic β-amyloid deposition and supranuclear cataracts in lenses from people with Alzheimer's disease

Xudong Huang, Colin L Masters, Rudolph E Tanzi, 2003, The Lancet.

Profiling the iron, copper and zinc content in primary neuron and astrocyte cultures by rapid online quantitative size exclusion chromatography-inductively coupled plasma-mass spectrometry.

C. Masters, A. Bush, R. Cherny, 2013, Metallomics : integrated biometal science.

Genetically Decreased Spinal Cord Copper Concentration Prolongs Life in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

J. Morrison, M. Beal, A. Bush, 2004, The Journal of Neuroscience.

Selective Intracellular Release of Copper and Zinc Ions from Bis(thiosemicarbazonato) Complexes Reduces Levels of Alzheimer Disease Amyloid-β Peptide*

C. Masters, A. Hill, R. Cherny, 2008, Journal of Biological Chemistry.

Dimerisation of N-acetyl-l-tyrosine ethyl ester and Aβ peptides via formation of dityrosine

R. Cherny, C. Barrow, F. Separovic, 2006, Free radical research.

The effect of paraformaldehyde fixation and sucrose cryoprotection on metal concentration in murine neurological tissue

C. Masters, A. Bush, R. Cherny, 2014 .

Alzheimer disease beta-amyloid activity mimics cholesterol oxidase.

S. Melov, A. Bush, R. Cherny, 2005, The Journal of clinical investigation.

Soluble pool of Aβ amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

C. Masters, A. Bush, R. Cherny, 1999, Annals of neurology.

Amyloid- (cid:2) Peptide A (cid:2) 3pE-42 Induces Lipid Peroxidation, Membrane Permeabilization, and Calcium Influx in Neurons *

C. Masters, A. Bush, R. Cherny, 2016 .

In-vitro studies of the effects of interferons on endometrial metabolism in sheep.

R. Cherny, L. Salamonsen, J. Findlay, 2019, Journal of reproduction and fertility. Supplement.

Lithium suppression of tau induces brain iron accumulation and neurodegeneration

C. Pantelis, A. Bush, R. Cherny, 2017, Molecular Psychiatry.

Copper-Dependent Inhibition of Human Cytochrome c Oxidase by a Dimeric Conformer of Amyloid-β1-42

C. Masters, R. Cherny, R. Cappai, 2005, The Journal of Neuroscience.

Pyroglutamate-Aβ: role in the natural history of Alzheimer's disease.

C. Masters, R. Cherny, Adam P. Gunn, 2010, The international journal of biochemistry & cell biology.

Ceruloplasmin gene‐deficient mice with experimental autoimmune encephalomyelitis show attenuated early disease evolution

T. Kilpatrick, H. Butzkueven, R. Cherny, 2014, Journal of neuroscience research.

Aqueous Dissolution of Alzheimer’s Disease Aβ Amyloid Deposits by Biometal Depletion*

C. Masters, Xudong Huang, R. Tanzi, 1999, The Journal of Biological Chemistry.

Treatment with a Copper-Zinc Chelator Markedly and Rapidly Inhibits β-Amyloid Accumulation in Alzheimer's Disease Transgenic Mice

C. Masters, Xudong Huang, R. Tanzi, 2001, Neuron.

Immunocytochemical localization of oestrogen receptors in the endometrium of the ewe.

R. Cherny, L. Salamonsen, J. Findlay, 1991, Reproduction, fertility, and development.

Restored degradation of the Alzheimer’s amyloid‐β peptide by targeting amyloid formation

C. Masters, R. Cherny, P. Crouch, 2009, Journal of neurochemistry.

Decreased plasma iron in Alzheimer's disease is due to transferrin desaturation.

Blaine R. Roberts, N. Faux, C. Masters, 2015, ACS chemical neuroscience.

Targeting metals rescues the phenotype in an animal model of tauopathy.

A. Bush, R. Cherny, P. Adlard, 2018, Metallomics : integrated biometal science.

Rapid Restoration of Cognition in Alzheimer's Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial Aβ

C. Masters, R. Tanzi, A. Bush, 2008, Neuron.

Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial.

A. Mackinnon, C. Masters, R. Tanzi, 2003, Archives of neurology.

The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson’s disease

David M. Shackleford, C. Masters, A. Bush, 2017, Acta neuropathologica communications.

Targeting the Progression of Parkinson’s Disease

A. Bush, R. Cherny, S. S. Mok, 2009, Current neuropharmacology.

Overexpression of Alzheimer's Disease Amyloid-β Opposes the Age-dependent Elevations of Brain Copper and Iron*

C. Masters, A. Bush, R. Cherny, 2002, The Journal of Biological Chemistry.

Copper in the brain and Alzheimer’s disease

A. Bush, R. Cherny, Ya Hui Hung, 2009, JBIC Journal of Biological Inorganic Chemistry.

Alzheimer's Disease Amyloid-β Binds Copper and Zinc to Generate an Allosterically Ordered Membrane-penetrating Structure Containing Superoxide Dismutase-like Subunits*

C. Masters, A. Bush, R. Cherny, 2001, The Journal of Biological Chemistry.

Zinc and copper modulate Alzheimer Aβ levels in human cerebrospinal fluid

K. Blennow, L. Launer, A. Bush, 2009, Neurobiology of Aging.

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export

Blaine R. Roberts, G. Egan, A. Bush, 2012, Nature Medicine.

Metal-Protein Attenuating Compounds (MPACs) for the Treatment of Alzheimers Disease

C. Masters, S. Melov, A. Bush, 2004 .

Regulation of insulin-regulated membrane aminopeptidase activity by its C-terminal domain.

R. Cherny, M. Parker, C. Morton, 2011, Biochemistry.

Metalloenzyme-like Activity of Alzheimer's Disease β-Amyloid

C. Masters, Xudong Huang, R. Tanzi, 2002, The Journal of Biological Chemistry.

Direct determination of zinc in plasma by graphite furnace atomic absorption spectrometry using palladium/magnesium and EDTA matrix modification with high temperature pyrolysis

R. Cherny, D. Hare, B. Roberts, 2017 .

The Aβcentric Pathway of Alzheimer’s Disease

C. Rowe, C. Masters, R. Cherny, 2007 .

The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson’s disease

Blaine R. Roberts, David M. Shackleford, C. Masters, 2012, The Journal of experimental medicine.

Studies in vitro of effects of steroid hormones and the blastocyst on endometrial function in the sheep.

R. Cherny, L. Salamonsen, J. Findlay, 1992, Reproduction, Fertility and Development.

Separation and culture of ovine endometrial epithelial and stromal cells: evidence of morphological and functional polarity.

R. Cherny, J. Findlay, 1990, Biology of reproduction.

Corticotrophs and Peptides

R. Smith, R. Cherny, V. Clifton, 2002, Archives of physiology and biochemistry.

Chelation and intercalation: complementary properties in a compound for the treatment of Alzheimer's disease.

C. Masters, R. Tanzi, A. Bush, 2000, Journal of structural biology.

Dopamine promotes α‐synuclein aggregation into SDS‐resistant soluble oligomers via a distinct folding pathway

S. Bottomley, C. Masters, A. Hill, 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The Alzheimer’s therapeutic PBT2 promotes amyloid‐β degradation and GSK3 phosphorylation via a metal chaperone activity

C. Masters, A. Bush, R. Cherny, 2011, Journal of neurochemistry.

Mitochondrial Oxidative Stress Causes Hyperphosphorylation of Tau

C. Masters, A. Hubbard, S. Melov, 2007, PloS one.

Increasing Cu bioavailability inhibits Aβ oligomers and tau phosphorylation

C. Masters, A. Bush, R. Cherny, 2009, Proceedings of the National Academy of Sciences.

Increasing Cu bioavailability inhibits A beta oligomers and tau phosphorylation

C. Masters, A. Bush, R. Cherny, 2009 .

Neurotoxic, Redox-competent Alzheimer's β-Amyloid Is Released from Lipid Membrane by Methionine Oxidation*

C. Masters, A. Bush, R. Cherny, 2003, Journal of Biological Chemistry.

Iron accumulation confers neurotoxicity to a vulnerable population of nigral neurons: implications for Parkinson’s disease

A. Bush, R. Cherny, P. Adlard, 2014, Molecular Neurodegeneration.

Utility of an improved model of amyloid-beta (Aβ1-42) toxicity in Caenorhabditis elegans for drug screening for Alzheimer’s disease

Blaine R. Roberts, C. Masters, A. Bush, 2012, Molecular Neurodegeneration.

The Caenorhabditis elegans Aβ1–42 Model of Alzheimer Disease Predominantly Expresses Aβ3–42*

Blaine R. Roberts, C. Masters, A. Bush, 2009, The Journal of Biological Chemistry.

Utility of an improved model of amyloid-beta (Aβ1-42) toxicity in Caenorhabditis elegansfor drug screening for Alzheimer’s disease

C. Masters, A. Bush, R. Cherny, 2012, Molecular Neurodegeneration.

Intracellular amyloid formation in muscle cells of Aβ-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification

C. Masters, A. Bush, R. Cherny, 2009, Molecular Neurodegeneration.

Degradation of the Alzheimer Disease Amyloid β-Peptide by Metal-dependent Up-regulation of Metalloprotease Activity*

C. Masters, A. Hill, A. Bush, 2006, Journal of Biological Chemistry.

A randomized, exploratory molecular imaging study targeting amyloid β with a novel 8-OH quinoline in Alzheimer's disease: The PBT2-204 IMAGINE study

C. Rowe, C. Masters, P. Maruff, 2017, Alzheimer's & dementia.

Methionine regulates copper/hydrogen peroxide oxidation products of Aβ

C. Masters, A. Bush, R. Cherny, 2005, Journal of peptide science : an official publication of the European Peptide Society.

Methylation of the Imidazole Side Chains of the Alzheimer Disease Amyloid-β Peptide Results in Abolition of Superoxide Dismutase-like Structures and Inhibition of Neurotoxicity*

C. Masters, A. Bush, R. Cherny, 2005, Journal of Biological Chemistry.

Cytosolic beta-amyloid deposition and supranuclear cataracts in lenses from people with Alzheimer's disease.

C. Masters, L. Chylack, Xudong Huang, 2003, Lancet.

An iron–dopamine index predicts risk of parkinsonian neurodegeneration in the substantia nigra pars compacta

Blaine R. Roberts, C. Masters, A. Bush, 2014 .

Cardiac Light Chain Amyloidosis: The Role of Metal Ions in Oxidative Stress and Mitochondrial Damage.

R. Cherny, M. Salmona, L. Diomede, 2017, Antioxidants & redox signaling.

Gender and genetic background effects on brain metal levels in APP transgenic and normal mice: implications for Alzheimer beta-amyloid pathology.

C. Masters, A. Bush, R. Cherny, 2006, Journal of inorganic biochemistry.

Amyloid-β Peptide Aβ3pE-42 Induces Lipid Peroxidation, Membrane Permeabilization, and Calcium Influx in Neurons*

C. Masters, A. Bush, R. Cherny, 2015, The Journal of Biological Chemistry.

Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease β‐amyloid

C. Masters, A. Bush, R. Cherny, 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Paradoxical Condensation of Copper with Elevated β-Amyloid in Lipid Rafts under Cellular Copper Deficiency Conditions

C. Masters, A. Bush, R. Cherny, 2009, The Journal of Biological Chemistry.

Alzheimer disease β-amyloid activity mimics cholesterol oxidase

S. Melov, A. Bush, R. Cherny, 2005 .

Neuronal Zinc Exchange with the Blood Vessel Wall Promotes Cerebral Amyloid Angiopathy in an Animal Model of Alzheimer's Disease

R. Palmiter, T. van Groen, A. Bush, 2004, The Journal of Neuroscience.

A novel approach to rapidly prevent age-related cognitive decline

A. Bush, R. Cherny, P. Adlard, 2013, Aging cell.

Oxidative processes in Alzheimer's disease: the role of Aβ-metal interactions

A. Bush, R. Cherny, T. Lynch, 2000, Experimental Gerontology.

Decreased serum zinc is an effect of ageing and not Alzheimer's disease.

Blaine R. Roberts, R. Martins, C. Masters, 2014, Metallomics : integrated biometal science.

Platinum-based inhibitors of amyloid-β as therapeutic agents for Alzheimer's disease

C. Masters, A. Bush, R. Cherny, 2008, Proceedings of the National Academy of Sciences.

Zinc in Alzheimer's and Parkinson's Diseases

A. Bush, R. Cherny, P. Adlard, 2013 .

Decreased Copper in Alzheimer's Disease Brain Is Predominantly in the Soluble Extractable Fraction

Blaine R. Roberts, C. Masters, A. Bush, 2013, International journal of Alzheimer's disease.

Chronic ferritin expression within murine dopaminergic midbrain neurons results in a progressive age-related neurodegeneration

Subramanian Rajagopalan, J. Andersen, R. Cherny, 2007, Brain Research.

Differential modulation of Alzheimer's disease amyloid beta-peptide accumulation by diverse classes of metal ligands.

C. Masters, A. Hill, R. Cherny, 2007, The Biochemical journal.

Estrogen Decreases Zinc Transporter 3 Expression and Synaptic Vesicle Zinc Levels in Mouse Brain*

R. Palmiter, A. Bush, R. Cherny, 2004, Journal of Biological Chemistry.

Radioiodinated clioquinol as a biomarker for β‐amyloid: Zn2+ complexes in Alzheimer's disease

C. Rowe, C. Masters, A. Bush, 2006, Aging cell.

Enhanced Toxicity and Cellular Binding of a Modified Amyloid β Peptide with a Methionine to Valine Substitution*

C. Masters, A. Bush, R. Cherny, 2004, Journal of Biological Chemistry.

The Caenorhabditis elegans A beta(1-42) Model of Alzheimer Disease Predominantly Expresses A beta(3-42)

Blaine R. Roberts, C. Masters, A. Bush, 2009 .

Overexpression of Aβ is associated with acceleration of onset of motor impairment and superoxide dismutase 1 aggregation in an amyotrophic lateral sclerosis mouse model

C. Masters, R. Cherny, Qiao-Xin Li, 2006, Aging cell.

Cysteine Oxidation within N-terminal Mutant Huntingtin Promotes Oligomerization and Delays Clearance of Soluble Protein*

S. Hersch, A. Bush, R. Cherny, 2011, The Journal of Biological Chemistry.

Effects of Neonatal Iron Feeding and Chronic Clioquinol Administration on the Parkinsonian Human A53T Transgenic Mouse.

A. Bush, R. Cherny, P. Adlard, 2016, ACS Chemical Neuroscience.

PBT2 Reduces Toxicity in a C. elegans Model of polyQ Aggregation and Extends Lifespan, Reduces Striatal Atrophy and Improves Motor Performance in the R6/2 Mouse Model of Huntington's Disease.

A. Bush, R. Cherny, D. Finkelstein, 2012, Journal of Huntington's disease.

Mechanisms of Copper Ion Mediated Huntington's Disease Progression

S. Hersch, A. Bush, R. Cherny, 2007, PloS one.

High order W02-reactive stable oligomers of amyloid-β are produced in vivo and in vitro via dialysis and filtration of synthetic amyloid-β monomer.

C. Masters, A. Bush, R. Cherny, 2015, Journal of Alzheimer's disease : JAD.

Altered selenium status in Huntington's disease: Neuroprotection by selenite in the N171-82Q mouse model

S. Hersch, A. Bush, R. Cherny, 2014, Neurobiology of Disease.

The Compound ATH434 Prevents Alpha-Synuclein Toxicity in a Murine Model of Multiple System Atrophy

R. Cherny, P. Adlard, N. Stefanova, 2021, Journal of Parkinson's disease.

Clioquinol Protects Against Cell Death in Parkinson's Disease Models In Vivo and In Vitro

C. Masters, A. Bush, R. Cherny, 2009 .

Zinc and copper modulate Alzheimer Abeta levels in human cerebrospinal fluid.

K. Blennow, L. Launer, A. Bush, 2009, Neurobiology of aging.

Three-dimensional elemental bio-imaging of Fe, Zn, Cu, Mn and P in a 6-hydroxydopamine lesioned mouse brain.

Philip Doble, Paul A Adlard, Ashley I Bush, 2010, Metallomics : integrated biometal science.

ATH434 Reverses Colorectal Dysfunction in the A53T Mouse Model of Parkinson’s Disease

R. Cherny, P. Adlard, J. Furness, 2021, Journal of Parkinson's disease.

Increased murine neonatal iron intake results in Parkinson-like neurodegeneration with age

J. Andersen, R. Cherny, Deepinder Kaur, 2007, Neurobiology of Aging.

Methionine oxidation: Implications for the mechanism of toxicity of the β-amyloid peptide from Alzheimer's disease

C. Masters, A. Bush, R. Cherny, 2003, Letters in Peptide Science.

Methionine oxidation: Implications for the mechanism of toxicity of the β-amyloid peptide from Alzheimer's disease

C. Masters, A. Bush, R. Cherny, 2003, Letters in Peptide Science.

Oligomeric AB in PBS-soluble extracts of human Alzheimer brain

C. Masters, R. Cherny, P. Guerette, 2000, Neurobiology of Aging.

Characterizing bathocuproine self‐association and subsequent binding to Alzheimer's disease amyloid β‐peptide by NMR

Colin L Masters, Ashley I Bush, C. Masters, 2004, Journal of peptide science : an official publication of the European Peptide Society.