T. Kawai

发表

Essential function for the kinase TAK1 in innate and adaptive immune responses

S. Akira, Shintaro Sato, H. Sanjo, 2005, Nature Immunology.

Viral infection augments Nod1/2 signaling to potentiate lethality associated with secondary bacterial infections.

S. Akira, T. Kawai, D. Baker, 2011, Cell host & microbe.

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

K. Ishii, S. Akira, A. Jung, 2006, Nature.

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

S. Akira, T. Kawai, 2010, Nature Immunology.

The chemotherapeutic agent DMXAA potently and specifically activates the TBK1–IRF-3 signaling axis

S. Akira, T. Kawai, H. Young, 2007, The Journal of experimental medicine.

Lipopolysaccharide-Inducible Genes the Expression of a Subset of Activation of IFN-Regulatory Factor 3 and MyD 88-Independent Pathway and Results in Lipopolysaccharide Stimulates the and Shizuo

S. Akira, Shintaro Sato, T. Kawai, 2001 .

Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function.

S. Akira, K. Takeda, T. Kawai, 1998, Immunity.

Unresponsiveness of MyD88-deficient mice to endotoxin.

S. Akira, T. Ogawa, K. Takeda, 1999, Immunity.

Poly IC triggers a cathepsin D- and IPS-1-dependent pathway to enhance cytokine production and mediate dendritic cell necroptosis.

S. Akira, T. Kawai, H. Kumar, 2013, Immunity.

Regulation of innate immune signalling pathways by the tripartite motif (TRIM) family proteins

S. Akira, T. Kawai, 2011, EMBO molecular medicine.

Toll-like receptors and their crosstalk with other innate receptors in infection and immunity.

S. Akira, T. Kawai, 2011, Immunity.

Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

C. Coban, K. Ishii, S. Akira, 2004, Nature Immunology.

Innate immune recognition of viral infection.

S. Akira, T. Kawai, 2006, Nature immunology.

TLR signaling.

S. Akira, T. Kawai, 2006, Cell death and differentiation.

Pathogen Recognition by the Innate Immune System

S. Akira, T. Kawai, H. Kumar, 2011, International reviews of immunology.

A Toll-like receptor recognizes bacterial DNA

S. Akira, T. Kaisho, Shintaro Sato, 2000, Nature.

IPS-1 Signaling Has a Nonredundant Role in Mediating Antiviral Responses and the Clearance of Respiratory Syncytial Virus

S. Akira, T. Kawai, Toshihiro Ito, 2012, The Journal of Immunology.

Differential Role of TLR- and RLR-Signaling in the Immune Responses to Influenza A Virus Infection and Vaccination

Shohei Koyama, Himanshu Kumar, Takeshi Tanimoto, 2007, The Journal of Immunology.

Toll-Like Receptor Signaling Pathways

Taro Kawai, Takumi Kawasaki, T. Kawai, 2014, Front. Immunol..

Innate immune responses through Toll-like receptor 3 require human-antigen-R-mediated Atp6v0d2 mRNA stabilization

T. Kawai, Takumi Kawasaki, Mohd Izwan Bin Zainol, 2019, Scientific Reports.

IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases.

S. Akira, K. Takeda, T. Kawai, 1999, International immunology.

NLRC5 Deficiency Does Not Influence Cytokine Induction by Virus and Bacteria Infections

S. Akira, T. Kawai, Y. Kumagai, 2011, The Journal of Immunology.

Transcriptional Control of Inflammatory

S. Akira, G. Natoli, T. Kawai, 2014 .

Enhanced TLR-mediated NF-IL6–dependent gene expression by Trib1 deficiency

Osamu Takeuchi, Toru Okamoto, Himanshu Kumar, 2007, The Journal of experimental medicine.

Host DNA Induced Inflammation and Autoimmune Diseases

T. Kawai, S. Pandey, 2014 .

Recognition of nucleic acids by pattern‐recognition receptors and its relevance in autoimmunity

S. Akira, T. Kawai, Takumi Kawasaki, 2011, Immunological reviews.

Toll/IL-1 Receptor Domain-Containing Adaptor Inducing IFN-β (TRIF) Associates with TNF Receptor-Associated Factor 6 and TANK-Binding Kinase 1, and Activates Two Distinct Transcription Factors, NF-κB and IFN-Regulatory Factor-3, in the Toll-Like Receptor Signaling 1

Shizuo Akira, Taro Kawai, Masahiro Yamamoto, 2003, The Journal of Immunology.

Toll-like receptor downstream signaling

S. Akira, T. Kawai, 2004, Arthritis research & therapy.

ZIP Kinase Triggers Apoptosis from Nuclear PML Oncogenic Domains

S. Akira, John Calvin Reed, T. Kawai, 2003, Molecular and Cellular Biology.

Mouse proteasomal ATPases Psmc3 and Psmc4: genomic organization and gene targeting.

S. Akira, N. Copeland, D. Gilbert, 2000, Genomics.

Cutting Edge: Cooperation of IPS-1- and TRIF-Dependent Pathways in Poly IC-Enhanced Antibody Production and Cytotoxic T Cell Responses

K. Ishii, S. Akira, T. Kawai, 2008, The Journal of Immunology.

IC-Enhanced Antibody Production and TRIF-Dependent Pathways in Poly Cutting Edge : Cooperation of IPS-1-and and Shizuo

K. Ishii, S. Akira, T. Kawai, 2007 .

Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells

C. Coban, K. Ishii, S. Akira, 2006, Nature Immunology.

Poly I:C-Induced Activation of NK Cells by CD8α+ Dendritic Cells via the IPS-1 and TRIF-Dependent Pathways1

S. Akira, T. Kawai, O. Takeuchi, 2009, The Journal of Immunology.

Iκb Kinase α Is Essential for Mature B Cell Development and Function

S. Akira, T. Kaisho, K. Takeda, 2001, The Journal of experimental medicine.

DNA-Containing Exosomes Derived from Cancer Cells Treated with Topotecan Activate a STING-Dependent Pathway and Reinforce Antitumor Immunity

K. Ishii, S. Akira, T. Kawai, 2017, The Journal of Immunology.

DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking

K. Ishii, S. Akira, T. Kawai, 2013, Proceedings of the National Academy of Sciences.

Physical and functional interactions between ZIP kinase and UbcH5.

S. Akira, T. Kawai, Y. Sekine, 2008, Biochemical and biophysical research communications.

A Cytosolic Sensor, PmDDX41, Binds Double Stranded-DNA and Triggers the Activation of an Innate Antiviral Response in the Shrimp Penaeus monodon via the STING-Dependent Signaling Pathway

T. Kawai, A. Tassanakajon, Piti Amparyup, 2019, Front. Immunol..

Cutting Edge: Roles of Caspase-8 and Caspase-10 in Innate Immune Responses to Double-Stranded RNA

S. Akira, Shintaro Sato, T. Kawai, 2006, The Journal of Immunology.

Pathophysiological Role of Nucleic Acid-Sensing Pattern Recognition Receptors in Inflammatory Diseases

T. Kawai, D. Ori, Norisuke Kano, 2022, Frontiers in Cellular and Infection Microbiology.

Antigen Presentation in the Lung

T. Kawai, Takumi Kawasaki, Moe Ikegawa, 2022, Frontiers in Immunology.

Inhibition of lipopolysaccharide‐induced inflammatory responses by 1′‐acetoxychavicol acetate

T. Kawai, Takumi Kawasaki, D. Ori, 2022, Genes to cells : devoted to molecular & cellular mechanisms.

MyD88 Signaling Is Indispensable for Primary Influenza A Virus Infection but Dispensable for Secondary Infection

S. Akira, T. Kawai, B. Seong, 2010, Journal of Virology.

PtdIns3P phosphatases MTMR3 and MTMR4 negatively regulate innate immune responses to DNA through modulating STING trafficking

T. Kawai, S. Suetsugu, Takumi Kawasaki, 2019, The Journal of Biological Chemistry.

Sensing Self and Non-Self DNA by Innate Immune Receptors and Their Signaling Pathways.

T. Kawai, N. H. Nagoor, Sophia P M Sok, 2018, Critical reviews in immunology.

Extrachromosomal Histone H2B Mediates Innate Antiviral Immune Responses Induced by Intracellular Double-Stranded DNA

A. Miyawaki, Asako Sakaue-Sawano, K. Ishii, 2009, Journal of Virology.

Hepatitis C Virus Nonstructural Protein 5A Modulates the Toll-Like Receptor-MyD88-Dependent Signaling Pathway in Macrophage Cell Lines

S. Akira, N. Hayashi, T. Kawai, 2007, Journal of Virology.

VP1686, a Vibrio Type III Secretion Protein, Induces Toll-like Receptor-independent Apoptosis in Macrophage through NF-κB Inhibition*

S. Akira, Masahiro Yamamoto, T. Kawai, 2006, Journal of Biological Chemistry.

Viral recognition and type I interferon production by Toll-like receptor and an RNA helicase, RIG-I

T. Kawai, O. Takeuchi, S. Uematsu, 2005 .

Regulation of Il6 expression by single CpG methylation in downstream of Il6 transcription initiation site

T. Kawai, Ayako Isotani, Takumi Kawasaki, 2022, iScience.

Cutting Edge: Impaired MHC Class I Expression in Mice Deficient for Nlrc5/Class I Transactivator

T. Kawai, A. Biswas, Koichi S. Kobayashi, 2012, The Journal of Immunology.

I Transactivator Expression in Mice Deficient for Nlrc 5 / Class Cutting Edge : Impaired MHC Class

T. Kawai, A. Biswas, Koichi S. Kobayashi, 2012 .

Involvement of the NLRP3 Inflammasome in Innate and Humoral Adaptive Immune Responses to Fungal β-Glucan1

S. Akira, P. Koenig, T. Kawai, 2009, The Journal of Immunology.

Signaling Through Nucleic Acid Sensors and Their Roles in Inflammatory Diseases

T. Kawai, D. Ori, Haruna Okude, 2021, Frontiers in Immunology.

Clearance of Respiratory Syncytial Virus Mediating Antiviral Responses and the IPS-1 Signaling Has a Nonredundant Role in

T. Kawai, Toshihiro Ito, M. Schaller, 2012 .

Essential role of B7-H1 in double-stranded RNA-induced augmentation of an asthma phenotype in mice.

S. Akira, T. Kawai, O. Takeuchi, 2011, American journal of respiratory cell and molecular biology.

TLR7-dependent and FcγR-independent production of type I interferon in experimental mouse lupus

S. Akira, Kindra M Kelly-Scumpia, T. Kawai, 2008, The Journal of experimental medicine.

The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA.

S. Akira, T. Kawai, T. Saitoh, 2010, Immunity.

The Roles of Two I (cid:2) B Kinase-related Kinases in Lipopolysaccharide and Double Stranded RNA Signaling and Viral Infection

S. Akira, T. Kaisho, Shintaro Sato, 2004 .

1'-acetoxychavicol acetate inhibits NLRP3-dependent inflammasome activation via mitochondrial ROS suppression.

T. Kawai, N. H. Nagoor, Takumi Kawasaki, 2021, International immunology.

Pathophysiological functions of self-derived DNA

T. Kawai, D. Ori, 2022, International reviews of immunology.

Nucleic acid sensing by T cells initiates Th2 cell differentiation

K. Ishii, S. Akira, T. Noda, 2014, Nature Communications.

TLR4-Mediated Signaling Pathways Toll-Like Receptor (TLR) 2- and Synergy and Cross-Tolerance Between

K. Takeda, T. Kawai, F. Nomura, 2013 .

MyD 88-Deficient Dendritic Cells Endotoxin-Induced Maturation of Hoshino and Shizuo

T. Kawai, O. Takeuchi, Akira Tsuneyasu Kaisho, 2001 .

Receptor 4 Expression Down-Regulation of Surface Toll-Like Peritoneal Macrophages Correlates with Cutting Edge: Endotoxin Tolerance in Mouse

S. Akira, Shintaro Sato, T. Kawai, 2000 .

recognizes bacterial DNA

S. Akira, T. Kaisho, Shintaro Sato, 2000 .

MyD 88-Dependent Signaling Pathway Through a Toll-Like Receptor 2-and Lipopeptide-2 Activates Immune Cells Lipopeptide Macrophage-Activating-Stereoisomer of the Mycoplasmal R Cutting Edge : Preferentially the and Shizuo

S. Akira, T. Kawai, O. Takeuchi, 1999 .

Impairment of Natural Killer Cytotoxic Activity and Interferon γ Production in Ccaat/Enhancer Binding Protein γ–Deficient Mice

S. Akira, T. Kaisho, K. Takeda, 1999, The Journal of experimental medicine.

Pathological role of Toll-like receptor signaling in cerebral malaria.

C. Coban, K. Ishii, S. Akira, 2006, International immunology.

IL-18 Binding Receptor Receptor-Related Protein as an Essential Receptor-Deficient Mice: Evidence for IL-1 Cutting Edge: Generation of IL-18

Y. Takeda, T. Kawai, H. Tsutsui, 1999 .

TRIF-Dependent Pathways Dendritic Cells via the IPS-1 and + α CD 8 Poly I : C-Induced Activation of NK Cells

S. Akira, T. Kawai, O. Takeuchi, 2009 .

Deletion of PIKfyve alters alveolar macrophage populations and exacerbates allergic inflammation in mice

S. Akira, T. Kawai, H. Miyata, 2017, The EMBO journal.

Zipper-interacting Protein Kinase (ZIPK) Modulates Canonical Wnt/β-Catenin Signaling through Interaction with Nemo-like Kinase and T-cell Factor 4 (NLK/TCF4)*

S. Akira, A. Nanbo, T. Kawai, 2011, The Journal of Biological Chemistry.

Thymocyte TCR Signaling Cutting Edge: Pivotal Function of Ubc13 in

Hiroaki, Shintaro Sato, Masahiro Yamamoto, 2022 .

The Ca2+-dependent pathway contributes to changes in the subcellular localization and extracellular release of interleukin-33.

K. Ishii, T. Kawai, Takumi Kawasaki, 2020, Biochemical and biophysical research communications.

InfectionsCytokine Induction by Virus and Bacteria NLRC5 Deficiency Does Not Influence

S. Akira, T. Kawai, Y. Kumagai, 2010 .

CD44 Participates in IP-10 Induction in Cells in Which Hepatitis C Virus RNA Is Replicating, through an Interaction with Toll-Like Receptor 2 and Hyaluronan

S. Akira, Y. Maehara, T. Kawai, 2012, Journal of Virology.

SnapShot: Pattern-Recognition Receptors

S. Akira, T. Kawai, 2007, Cell.

Identification of RPL15 60S Ribosomal Protein as a Novel Topotecan Target Protein That Correlates with DAMP Secretion and Antitumor Immune Activation

K. Ishii, T. Kawai, T. Matsuda, 2022, The Journal of Immunology.

Hu Antigen R Regulates Antiviral Innate Immune Responses through the Stabilization of mRNA for Polo-like Kinase 2

S. Akira, T. Kawai, Takumi Kawasaki, 2018, The Journal of Immunology.

Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase-mediated antiviral response

S. Akira, T. Kawai, O. Takeuchi, 2017, Proceedings of the National Academy of Sciences.

Contribution of IPS-1 to polyI:C-induced cytokine production in conjunctival epithelial cells.

S. Akira, T. Kawai, S. Kinoshita, 2011, Biochemical and biophysical research communications.

IPS-1 differentially induces TRAIL, BCL2, BIRC3 and PRKCE in type I interferons-dependent and -independent anticancer activity

S. Akira, A. Takaoka, T. Kawai, 2015, Cell Death and Disease.

Negative Regulation of Melanoma Differentiation-associated Gene 5 (MDA5)-dependent Antiviral Innate Immune Responses by Arf-like Protein 5B*

S. Akira, T. Kawai, O. Takeuchi, 2014, The Journal of Biological Chemistry.

Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I–mediated antiviral innate immunity

S. Akira, T. Kawai, O. Takeuchi, 2014, Proceedings of the National Academy of Sciences.

Lipopolysaccharide Stimulates the MyD88-Independent Pathway and Results in Activation of IFN-Regulatory Factor 3 and the Expression of a Subset of Lipopolysaccharide-Inducible Genes1

S. Akira, Shintaro Sato, T. Kawai, 2001, The Journal of Immunology.

Signaling to NF-?B by Toll-like receptors

Shizuo Akira, Taro Kawai, S. Akira, 2007 .

Signaling to NF-kappaB by Toll-like receptors.

Shizuo Akira, Taro Kawai, S. Akira, 2007, Trends in molecular medicine.

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.

S. Akira, T. Ogawa, H. Sanjo, 1999, Immunity.

Toll-like receptors and innate immunity.

Himanshu Kumar, Shizuo Akira, Taro Kawai, 2009, Biochemical and biophysical research communications.

Discrimination Between Self and Non-Self-Nucleic Acids by the Innate Immune System

T. Kawai, Takumi Kawasaki, 2018, International Review of Cell and Molecular Biology.

Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product.

S. Akira, Y. Takeda, T. Ogawa, 1999, Journal of immunology.

Cutting Edge: Preferentially the R-Stereoisomer of the Mycoplasmal Lipopeptide Macrophage-Activating Lipopeptide-2 Activates Immune Cells Through a Toll-Like Receptor 2- and MyD88-Dependent Signaling Pathway1

S. Akira, T. Kawai, O. Takeuchi, 2000, The Journal of Immunology.

TLR13 Recognizes Bacterial 23S rRNA Devoid of Erythromycin Resistance–Forming Modification

Stefan Bauer, Carsten J. Kirschning, Hermann Wagner, 2012, Science.

Innate immune recognition of viral infection

Shizuo Akira, Taro Kawai, S. Akira, 2006, Nature Immunology.

Baculovirus Induces Type I Interferon Production through Toll-Like Receptor-Dependent and -Independent Pathways in a Cell-Type-Specific Manner

K. Ishii, S. Akira, T. Kawai, 2009, Journal of Virology.

Prx4 acts as DAMP in shrimp, enhancing bacterial resistance via the toll pathway and prophenoloxidase activation

T. Kawai, Kunlaya Somboonwiwat, Supitcha Wanvimonsuk, 2022, iScience.

Cutting Edge: Endotoxin Tolerance in Mouse Peritoneal Macrophages Correlates with Down-Regulation of Surface Toll-Like Receptor 4 Expression1

S. Akira, Shintaro Sato, K. Takeda, 2000, The Journal of Immunology.

Discrimination of bacterial lipoproteins by Toll-like receptor 6.

S. Akira, K. Takeda, T. Kawai, 2001, International immunology.

Microbial sensing by Toll-like receptors and intracellular nucleic acid sensors.

S. Akira, T. Kawai, S. Pandey, 2014, Cold Spring Harbor perspectives in biology.

The roles of TLRs, RLRs and NLRs in pathogen recognition.

Shizuo Akira, Taro Kawai, S. Akira, 2009, International immunology.

erratum A Toll-like receptor recognizes bacterial DNA

S. Akira, T. Kaisho, Shintaro Sato, 2001, Nature.

Exploration of Pattern Recognition Receptor Agonists as Candidate Adjuvants

T. Kawai, Takumi Kawasaki, G. Ong, 2021, Frontiers in Cellular and Infection Microbiology.

Pathogen recognition with Toll-like receptors.

S. Akira, T. Kawai, 2005, Current opinion in immunology.

Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

K. Ishii, S. Akira, T. Noda, 2009, Proceedings of the National Academy of Sciences.

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

S. Akira, T. Kawai, O. Takeuchi, 2008, Nature.

Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses.

S. Akira, T. Kawai, O. Takeuchi, 2007, Immunity.

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

Osamu Takeuchi, Himanshu Kumar, Hiroki Kato, 2005, Nature Immunology.

The Roles of Two IκB Kinase-related Kinases in Lipopolysaccharide and Double Stranded RNA Signaling and Viral Infection

Osamu Takeuchi, Katsuaki Hoshino, Shizuo Akira, 2004, The Journal of experimental medicine.

Dissecting negative regulation of Toll-like receptor signaling.

Shizuo Akira, Taro Kawai, S. Akira, 2012, Trends in immunology.

TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

C. Coban, K. Ishii, S. Akira, 2008, Nature.

Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells.

S. Akira, T. Kawai, O. Takeuchi, 2011, Immunity.

Pathogen recognition in the innate immune response.

S. Akira, T. Kawai, H. Kumar, 2009, The Biochemical journal.

The Atg5–Atg12 conjugate associates with innate antiviral immune responses

A. Miyawaki, K. Ishii, S. Akira, 2007, Proceedings of the National Academy of Sciences.

Sequential control of Toll-like receptor–dependent responses by IRAK1 and IRAK2

Osamu Takeuchi, Hiroki Kato, Shizuo Akira, 2008, Nature Immunology.

Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-α induction

C. Coban, K. Ishii, S. Akira, 2005, The Journal of experimental medicine.

Influenza A Virus Polymerase Inhibits Type I Interferon Induction by Binding to Interferon β Promoter Stimulator 1*

S. Akira, Y. Kawaoka, A. Takada, 2010, The Journal of Biological Chemistry.

Limb and skin abnormalities in mice lacking IKKalpha.

S. Akira, K. Yoshikawa, H. Sanjo, 1999, Science.

MyD88-Deficient Dendritic Cells Endotoxin-Induced Maturation of

Osamu Takeuchi, Shizuo Akira, Tsuneyasu Kaisho, 2013 .

Endotoxin-Induced Maturation of MyD88-Deficient Dendritic Cells1

S. Akira, T. Kaisho, T. Kawai, 2001, The Journal of Immunology.

Receptor Signaling IFN-Regulatory Factor-3, in the Toll-Like B and κ Distinct Transcription Factors, NF- TANK-Binding Kinase 1, and Activates Two with TNF Receptor-Associated Factor 6 and (TRIF) Associates β Adaptor Inducing IFN- Toll/IL-1 Receptor Domain-Containing

S. Akira, Shintaro Sato, K. Takeda, 2013 .

TLR6: A novel member of an expanding toll-like receptor family.

S. Akira, N. Copeland, D. Gilbert, 1999, Gene.

Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity

S. Akira, N. Copeland, D. Gilbert, 1999, Oncogene.

ZIP Kinase, a Novel Serine/Threonine Kinase Which Mediates Apoptosis

Shizuo Akira, Taro Kawai, S. Akira, 1998, Molecular and Cellular Biology.

Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling

K. Ishii, S. Akira, Shintaro Sato, 2006, Nature Immunology.

Toll‐like Receptor and RIG‐1‐like Receptor Signaling

Shizuo Akira, Taro Kawai, S. Akira, 2008, Annals of the New York Academy of Sciences.

Phosphorylation of threonine-265 in Zipper-interacting protein kinase plays an important role in its activity and is induced by IL-6 family cytokines.

S. Akira, T. Kawai, Y. Sekine, 2006, Immunology letters.

Physical and functional interactions between STAT3 and ZIP kinase.

Kenji Sugiyama, Shizuo Akira, Taro Kawai, 2005, International immunology.

Duet is a novel serine/threonine kinase with Dbl-Homology (DH) and Pleckstrin-Homology (PH) domains.

S. Akira, H. Sanjo, T. Kawai, 1999, Gene.

DRAKs, Novel Serine/Threonine Kinases Related to Death-associated Protein Kinase That Trigger Apoptosis*

S. Akira, H. Sanjo, T. Kawai, 1998, The Journal of Biological Chemistry.

TLR signaling

S. Akira, T. Kawai, Shizuo Akira, 2006, Cell Death and Differentiation.

Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin

C. Coban, K. Ishii, S. Akira, 2005, The Journal of experimental medicine.

Meta-analysis of single-cell RNA-seq data reveals phenotypic switching of immune cells in severe COVID-19 patients

T. Kawai, Md Zobaer Hasan, Syful Islam, 2021, Computers in Biology and Medicine.

Synergy and Cross-Tolerance Between Toll-Like Receptor (TLR) 2- and TLR4-Mediated Signaling Pathways1

S. Akira, Shintaro Sato, K. Takeda, 2000, The Journal of Immunology.

TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells.

S. Akira, Shintaro Sato, H. Sanjo, 2006, International immunology.

Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome

K. Mizuguchi, K. Ishii, S. Akira, 2014, Nature Communications.

Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus.

Osamu Takeuchi, Gunther Hartmann, Hiroki Kato, 2009, Immunity.

The Shared Antibiotic Resistome of Soil Bacteria and Human Pathogens

S. Akira, J. Buer, T. Kawai, 2019 .

Lymphocytoid Choriomeningitis Virus Activates Plasmacytoid Dendritic Cells and Induces a Cytotoxic T-Cell Response via MyD88

S. Akira, A. Jung, T. Kawai, 2007, Journal of Virology.

Cytosolic nucleic acid sensors and innate immune regulation

T. Kawai, Motoya Murase, D. Ori, 2017, International reviews of immunology.

Completion of the entire hepatitis C virus life-cycle in genetically humanized mice

Charles M. Rice, Shizuo Akira, Taro Kawai, 2013, Nature.

Cutting Edge: TLR-Dependent Viral Recognition Along with Type I IFN Positive Feedback Signaling Masks the Requirement of Viral Replication for IFN-α Production in Plasmacytoid Dendritic Cells1

S. Akira, T. Kawai, O. Takeuchi, 2009, The Journal of Immunology.

Virus Infection and Vaccination in the Immune Responses to Influenza A Differential Role of TLR-and RLR-Signaling and Shizuo

C. Coban, K. Ishii, S. Akira, 2007 .

Essential role of IPS-1 in innate immune responses against RNA viruses

C. Coban, K. Ishii, S. Akira, 2006, The Journal of experimental medicine.

A Toll-like receptor–independent antiviral response induced by double-stranded B-form DNA

C. Coban, K. Ishii, S. Akira, 2006, Nature Immunology.

SARS-CoV-2 infection initiates interleukin-17-enriched transcriptional response in different cells from multiple organs

T. Kawai, Md Zobaer Hasan, S. Islam, 2021, Scientific Reports.

Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor.

S. Akira, Y. Takeda, K. Takeda, 1999, Journal of immunology.

Inhibition of IRF3-dependent antiviral responses by cellular and viral proteins

S. Akira, T. Kawai, T. Tsuchida, 2009, Cell Research.

TAK 1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells

S. Akira, Shintaro Sato, H. Sanjo, 2006 .

Signaling to NF-kB by Toll-like receptors

S. Akira, T. Kawai, 2007 .

Signaling to NFk B by Toll-like receptors

S. Akira, T. Kawai, 2007 .

Antiviral signaling through pattern recognition receptors.

Shizuo Akira, Taro Kawai, S. Akira, 2006, Journal of biochemistry.

RIG-I Detects mRNA of Intracellular Salmonella enterica Serovar Typhimurium during Bacterial Infection

S. Akira, M. Merad, T. Kawai, 2014, mBio.

TRAF6 and MEKK1 Play a Pivotal Role in the RIG-I-like Helicase Antiviral Pathway*

S. Akira, A. Yoshimura, T. Kawai, 2008, Journal of Biological Chemistry.

Antiviral Signaling Through TLRs and RLHs

T. Kawai, 2008 .

Penaeus monodon Interferon Regulatory Factor (PmIRF) Activates IFNs and Antimicrobial Peptide Expression via a STING-Dependent DNA Sensing Pathway

T. Kawai, A. Tassanakajon, Piti Amparyup, 2022, Frontiers in Immunology.

Expression in Mammalian Cells Baculovirus Attenuates Transgene Innate Immune Response Induced

K. Ishii, S. Akira, Masahiro Yamamoto, 2014 .

Innate Immune Response Induced by Baculovirus Attenuates Transgene Expression in Mammalian Cells

K. Ishii, S. Akira, Masahiro Yamamoto, 2013, Journal of Virology.

Penaeus monodon IKKs Participate in Regulation of Cytokine-Like System and Antiviral Responses of Innate Immune System

T. Kawai, A. Tassanakajon, Piti Amparyup, 2019, Front. Immunol..

[Nucleic acids recognition by innate immunity].

S. Akira, T. Kawai, T. Saitoh, 2012, Uirusu.

Thymocyte TCR Signaling Cutting Edge: Pivotal Function of Ubc13 in

K. Ishii, S. Akira, Shintaro Sato, 2006 .

The second messenger phosphatidylinositol-5-phosphate facilitates antiviral innate immune signaling.

S. Akira, D. Standley, T. Kawai, 2013, Cell host & microbe.

Identification of nucleoporin 93 (Nup93) that mediates antiviral innate immune responses.

T. Kawai, Md Zobaer Hasan, Takumi Kawasaki, 2019, Biochemical and biophysical research communications.

Type-I Interferon is Critical for FasL Expression on Lung Cells to Determine the Severity of Influenza

S. Akira, T. Kawai, H. Kida, 2013, PloS one.

Alveolar macrophages instruct CD8+ T cell expansion by antigen cross-presentation in lung.

K. Ishii, T. Kawai, Toshihiro Ito, 2022, Cell reports.

Genome organization and definition of the Penaeus monodon viral responsive protein 15 (PmVRP15) promoter.

T. Kawai, C. Lo, A. Tassanakajon, 2019, Fish & shellfish immunology.

Intravesicular Acidification Regulates Lipopolysaccharide Inflammation and Tolerance through TLR4 Trafficking

Shintaro Sato, T. Kawai, M. Ikawa, 2018, The Journal of Immunology.

TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus

S. Akira, J. Kohyama, T. Kawai, 2015, Nature Communications.

TLR signaling.

S. Akira, T. Kawai, 2006, Current topics in microbiology and immunology.

Generating an organ-deficient animal model using a multi-targeted CRISPR-Cas9 system

T. Kawai, S. Yuri, Jonathan Jun-Yong Lim, 2023, bioRxiv.

IPS-1 is crucial for DAP3-mediated anoikis induction by caspase-8 activation

S. Akira, John Calvin Reed, T. Kawai, 2009, Cell Death and Differentiation.

NF‐κB activation through IKK‐i‐dependent I‐TRAF/TANK phosphorylation

S. Akira, T. Kawai, K. Nakanishi, 2000, Genes to cells : devoted to molecular & cellular mechanisms.

Secretion of mitochondrial DNA via exosomes promotes inflammation in Behçet's syndrome

Masahito Ueda, T. Kawai, Y. Maeda, 2023, The EMBO journal.

Pathogen Recognition by the Innate Immune System

S. Akira, T. Kawai, H. Kumar, 2011, International reviews of immunology.

TLR13 Recognizes Bacterial 23S rRNA Devoid of Erythromycin Resistance–Forming Modification

S. Akira, J. Buer, T. Kawai, 2012, Science.

InfectionsCytokine Induction by Virus and Bacteria NLRC5 Deficiency Does Not Influence

S. Akira, T. Kawai, Y. Kumagai, 2010 .

NLRC5 Deficiency Does Not Influence Cytokine Induction by Virus and Bacteria Infections

S. Akira, T. Kawai, Y. Kumagai, 2010 .

IPS-1 Signaling Has a Nonredundant Role in Mediating Antiviral Responses and the Clearance of Respiratory Syncytial Virus

S. Akira, T. Kawai, Toshihiro Ito, 2012, The Journal of Immunology.

Bioinformatics Analysis of Inhibition Activation SHP-2 by Galangal as Activating Agent of Cancer Immunotherapy

E. Meiyanto, T. Kawai, Dyaningtyas Dewi Pamungkas Putri, 2023, Indonesian Journal of Cancer Chemoprevention.

CD44 Participates in IP-10 Induction in Cells in Which Hepatitis C Virus RNA Is Replicating, through an Interaction with Toll-Like Receptor 2 and Hyaluronan

S. Akira, Y. Maehara, T. Kawai, 2012, Journal of Virology.

InfectionsCytokine Induction by Virus and Bacteria NLRC5 Deficiency Does Not Influence

S. Akira, T. Kawai, Y. Kumagai, 2010 .

This information is current as Clearance of Respiratory Syncytial Virus Mediating Antiviral Responses and the IPS-1 Signaling Has a Nonredundant Role in

T. Kawai, Toshihiro Ito, M. Schaller, 2012 .

The Roles of Two IκB Kinase-related Kinases in Lipopolysaccharide and Double Stranded RNA Signaling and Viral Infection

S. Akira, T. Kaisho, Shintaro Sato, 2004, The Journal of experimental medicine.

Decoding Toll-like receptors: Recent insights and perspectives in innate immunity.

T. Kawai, D. Ori, Moe Ikegawa, 2024, Immunity.

Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-α induction

C. Coban, K. Ishii, S. Akira, 2005, The Journal of experimental medicine.

TLR7-dependent and FcγR-independent production of type I interferon in experimental mouse lupus

S. Akira, T. Kawai, O. Takeuchi, 2008, The Journal of experimental medicine.

MyD 88-Deficient Dendritic Cells Endotoxin-Induced Maturation of Hoshino and Shizuo

T. Kawai, O. Takeuchi, Akira Tsuneyasu Kaisho, 2001 .

Enhanced TLR-mediated NF-IL6–dependent gene expression by Trib1 deficiency

K. Ishii, S. Akira, Shintaro Sato, 2007, The Journal of experimental medicine.