R. O’Keefe

Klaus Klaushofer, Piet Geusens, Regis O'Keefe, 2010, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Smad2 and 3 Mediate Transforming Growth Factor-β1-Induced Inhibition of Chondrocyte Maturation* *The work was supported by National Health Services Grant AR-38945 (to R.J.O.) and an Orthopaedic Research Education Foundation Award (to C.M.F.).

E. Schwarz, J. Puzas, P. Reynolds, 2000, Endocrinology.

Development of siRNA Technology to Prevent Scar Formation in Tendon Repair

R. O’Keefe, 2012 .

Generation of a transgenic mouse model with chondrocyte‐specific and tamoxifen‐inducible expression of Cre recombinase

R. O’Keefe, Di Chen, Mo Chen, 2007, Genesis.

Teriparatide therapy enhances devitalized femoral allograft osseointegration and biomechanics in a murine model.

E. Schwarz, R. O’Keefe, H. Awad, 2011, Bone.

Viral interleukin-10 gene inhibition of inflammation, osteoclastogenesis, and bone resorption in response to titanium particles.

E. Schwarz, J. Puzas, R. O’Keefe, 2002, Arthritis and rheumatism.

Effect of transforming growth factor-β on DNA synthesis by growth plate chondrocytes: Modulation by factors present in serum

J. Puzas, R. O’Keefe, R. Rosier, 1988, Calcified Tissue International.

Deletion of the transforming growth factor β receptor type II gene in articular chondrocytes leads to a progressive osteoarthritis-like phenotype in mice.

R. O’Keefe, Y. Yang, H. Im, 2013, Arthritis and rheumatism.

NF-κB Regulates VCAM-1 Expression on Fibroblast-Like Synoviocytes1

E. Schwarz, R. O’Keefe, Ping Li, 2000, The Journal of Immunology.

Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair.

E. Schwarz, J. Puzas, R. O’Keefe, 2002, The Journal of clinical investigation.

Regulation of embryonic endochondral ossification by Smurf2

R. O’Keefe, Di Chen, Qiuqian Wu, 2008, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Overexpression of Smurf2 Stimulates Endochondral Ossification Through Upregulation of β‐Catenin

R. O’Keefe, Di Chen, Qiuqian Wu, 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Induction of an osteoarthritis-like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice.

E. Schwarz, J. Puzas, R. O’Keefe, 2008, Arthritis and rheumatism.

Smad6 Interacts with Runx2 and Mediates Smad Ubiquitin Regulatory Factor 1-induced Runx2 Degradation*

R. O’Keefe, Di Chen, L. Xing, 2006, Journal of Biological Chemistry.

Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19.

H. Chi, P. Romano, J. Puzas, 1999, Genomics.

Clinical presentation of alveolar soft-part sarcoma.

S. Scully, R. O’Keefe, H. Mankin, 1994, Clinical orthopaedics and related research.

Structural bone allograft combined with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineering.

R. Guldberg, E. Schwarz, R. O’Keefe, 2006, Tissue engineering.

Immunohistochemical study of receptor activator of nuclear factor kappa‐B ligand (RANK‐L) in human osteolytic bone tumors

Christopher R. Good, E. Schwarz, J. Puzas, 2002, Journal of Surgical Oncology.

Tumor necrosis factor‐α/nuclear transcription factor‐κB signaling in periprosthetic osteolysis

G. Kollias, E. Schwarz, J. Puzas, 2000 .

Efficacy of Etanercept for Wear Debris‐Induced Osteolysis

E. Schwarz, E. Schwarz, R. O’Keefe, 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Short-term and Long-term Orthopaedic Issues in Patients With Fragility Fractures

S. Kates, R. O’Keefe, S. Bukata, 2011, Clinical orthopaedics and related research.

HiPER1, a phosphatase of the endoplasmic reticulum with a role in chondrocyte maturation.

P. Romano, J. Puzas, P. Reynolds, 1998, Journal of cell science.

A mouse model of flexor tendon repair.

R. O’Keefe, H. Awad, Sys Hasslund, 2014, Methods in molecular biology.

Titanium particles stimulate COX-2 expression in synovial fibroblasts through an oxidative stress-induced, calpain-dependent, NF-kappaB pathway.

E. Schwarz, R. O’Keefe, H. Drissi, 2009, American journal of physiology. Cell physiology.

Transforming growth factor‐β1 induced alteration of skeletal morphogenesis in vivo

E. Schwarz, J. Puzas, R. O’Keefe, 2004 .

Inhibition of the Wnt-β-catenin and Notch signaling pathways sensitizes osteosarcoma cells to chemotherapy.

R. O’Keefe, Y. Konttinen, Di Chen, 2013, Biochemical and biophysical research communications.

Late recurrence of giant-cell tumor of bone. A report of four cases.

S. Scully, R. O’Keefe, R. O'Donnell, 1994, The Journal of bone and joint surgery. American volume.

Differential regulation of EP receptor isoforms during chondrogenesis and chondrocyte maturation.

E. Schwarz, R. O’Keefe, H. Drissi, 2005, Biochemical and biophysical research communications.

Primary murine limb bud mesenchymal cells in long-term culture complete chondrocyte differentiation: TGF-beta delays hypertrophy and PGE2 inhibits terminal differentiation.

E. Schwarz, J. Puzas, R. O’Keefe, 2004, Bone.

FoxO1 is a crucial mediator of TGF-β/TAK1 signaling and protects against osteoarthritis by maintaining articular cartilage homeostasis

R. O’Keefe, Cuicui Wang, Jie Shen, 2020, Proceedings of the National Academy of Sciences.

Lead Toxicity in the Skeleton and Its Role in Osteoporosis

J. Puzas, R. O’Keefe, R. Rosier, 2004 .

Bone metastasis: an update on mechanisms of bone resorption and therapeutic strategies

E. Schwarz, R. O’Keefe, B. Boyce, 2000 .

In Vivo RANK Signaling Blockade Using the Receptor Activator of NF‐κB:Fc Effectively Prevents and Ameliorates Wear Debris‐Induced Osteolysis via Osteoclast Depletion Without Inhibiting Osteogenesis

A. Boskey, E. Schwarz, J. Puzas, 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Isolation and Culture of Periosteum-Derived Progenitor Cells from Mice.

R. O’Keefe, Jie Shen, G. Sharma, 2021, Methods in molecular biology.

A Perspective: Engineering Periosteum for Structural Bone Graft Healing

R. Guldberg, E. Schwarz, R. O’Keefe, 2008, Clinical orthopaedics and related research.

Loss of Dnmt3b in Chondrocytes Leads to Delayed Endochondral Ossification and Fracture Repair

R. O’Keefe, Y. Abu-Amer, Cuicui Wang, 2018, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Wnt‐mediated regulation of chondrocyte maturation: Modulation by TGF‐β

E. Schwarz, R. O’Keefe, Di Chen, 2005, Journal of cellular biochemistry.

Aging periosteal progenitor cells have reduced regenerative responsiveness to bone injury and to the anabolic actions of PTH 1-34 treatment.

C. Beck, E. Schwarz, R. O’Keefe, 2014, Bone.

Thrombospondin-2 Influences the Proportion of Cartilage and Bone During Fracture Healing

S. Goldstein, R. O’Keefe, J. Meganck, 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Oral Pentoxifylline Inhibits Release of Tumor Necrosis Factor-Alpha from Human Peripheral Blood Monocytes: A Potential Treatment for Aseptic Loosening of Total Joint Components

E. Schwarz, J. Puzas, R. O’Keefe, 2001, The Journal of bone and joint surgery. American volume.

A Role for the BMP Antagonist Chordin in Endochondral Ossification

J. Puzas, P. Reynolds, R. O’Keefe, 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

American Society for Bone and Mineral Research‐Orthopaedic Research Society Joint Task Force Report on Cell‐Based Therapies – Secondary Publication

C. Colnot, F. Barry, R. Guldberg, 2020, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

American Society for Bone and Mineral Research‐Orthopaedic Research Society Joint Task Force Report on Cell‐Based Therapies

C. Colnot, F. Barry, R. Guldberg, 2019, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Lead Exposure Inhibits Fracture Healing and Is Associated with Increased Chondrogenesis, Delay in Cartilage Mineralization, and a Decrease in Osteoprogenitor Frequency

E. Schwarz, J. Puzas, R. O’Keefe, 2005, Environmental health perspectives.

Smad3‐Deficient Chondrocytes Have Enhanced BMP Signaling and Accelerated Differentiation

E. Schwarz, R. O’Keefe, Di Chen, 2005, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Axin1 and Axin2 Are Regulated by TGF‐β and Mediate Cross‐talk between TGF‐β and Wnt Signaling Pathways

Debbie Y. Dao, R. O’Keefe, Di Chen, 2007, Annals of the New York Academy of Sciences.

PGE2 Receptor Subtype 1 (EP1) Regulates Mesenchymal Stromal Cell Osteogenic Differentiation by Modulating Cellular Energy Metabolism

R. O’Keefe, Bradley N. Mills, J. Jonason, 2017, Journal of cellular biochemistry.

Loss of the PGE2 receptor EP1 enhances bone acquisition, which protects against age and ovariectomy-induced impairments in bone strength.

E. Schwarz, R. O’Keefe, T. Sheu, 2015, Bone.

Increased insulin mRNA binding protein-3 expression correlates with vascular enhancement of renal cell carcinoma by intravenous contrast-CT and is associated with bone metastasis

E. Schwarz, R. O’Keefe, G. Yin, 2015, Journal of bone oncology.

Inhibition of beta‐catenin signaling by Pb leads to incomplete fracture healing

J. Puzas, R. O’Keefe, T. Sheu, 2014, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Role of Pentoxifylline in Preventing Radiation Damage to Epiphyseal Growth Plate Chondrocytes

P. Okunieff, L. Constine, E. Schwarz, 2002, Radiation research.

Deletion of EP4 in S100a4-lineage cells reduces scar tissue formation during early but not later stages of tendon healing

R. O’Keefe, Alayna E. Loiselle, Katherine T. Best, 2017, bioRxiv.

The Spatiotemporal Role of COX-2 in Osteogenic and Chondrogenic Differentiation of Periosteum-Derived Mesenchymal Progenitors in Fracture Repair

R. O’Keefe, J. Jiao, H. Herschman, 2014, PloS one.

Osteoporosis in Men. The Effects of Gender on Skeletal Health.

R. O’Keefe, 2001 .

Teriparatide (human PTH1-34) compensates for impaired fracture healing in COX-2 deficient mice.

C. Beck, E. Schwarz, R. O’Keefe, 2018, Bone.

PTH‐enhanced structural allograft healing is associated with decreased angiopoietin‐2–mediated arteriogenesis, mast cell accumulation, and fibrosis

E. Schwarz, R. O’Keefe, L. Calvi, 2013, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Delayed short‐course treatment with teriparatide (PTH1–34) improves femoral allograft healing by enhancing intramembranous bone formation at the graft–host junction

E. Schwarz, R. O’Keefe, H. Awad, 2012, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Endogenous tissue engineering: PTH therapy for skeletal repair

E. Schwarz, R. O’Keefe, H. Awad, 2011, Cell and Tissue Research.

Teriparatide (1‐34 human PTH) regulation of osterix during fracture repair

E. Schwarz, R. O’Keefe, H. Drissi, 2008, Journal of cellular biochemistry.

Mastocytosis presenting as a skeletal disorder.

R. O’Keefe, R. Rosier, D. Hicks, 1996, The Iowa orthopaedic journal.

TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages

E. Schwarz, R. O’Keefe, T. Sheu, 2013, Journal of Cell Science.

Treatment of multifocal lymphoma of bone with intensified Promace‐Cytabom chemotherapy and involved field radiotherapy

L. Constine, R. O’Keefe, David G. Hicks, 1998, American journal of hematology.

A Novel Animal Model for Studying Silicone Gel–Related Capsular Contracture

H. Langstein, R. O’Keefe, Jacqueline P. Williams, 2010, Plastic and reconstructive surgery.

Tumor metastasis and the reciprocal regulation of prometastatic and antimetastatic factors by nuclear factor kappaB.

J. Puzas, E. Schwarz, R. O’Keefe, 2000, Cancer research.

Nuclear factor-kappaB-dependent mechanisms in breast cancer cells regulate tumor burden and osteolysis in bone.

E. Schwarz, J. Puzas, R. O’Keefe, 2005, Cancer research.

Low-Dose and Short-Duration Matrix Metalloproteinase 9 Inhibition Does Not Affect Adhesion Formation during Murine Flexor Tendon Healing

R. O’Keefe, W. Hammert, Alayna E. Loiselle, 2016, Plastic and reconstructive surgery.

Parathyroid hormone 1–34 enhances extracellular matrix deposition and organization during flexor tendon repair

R. O’Keefe, W. Hammert, H. Awad, 2015, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Periosteal Progenitor Cell Fate in Segmental Cortical Bone Graft Transplantations: Implications for Functional Tissue Engineering

R. Guldberg, E. Schwarz, R. O’Keefe, 2005, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

SYMPOSIUM: NEW APPROACHES TO ALLOGRAFT TRANSPLANTATION

R. Guldberg, E. Schwarz, R. O’Keefe, 2008 .

Adhesions in a murine flexor tendon graft model: Autograft versus allograft reconstruction

E. Schwarz, R. O’Keefe, David J. Mitten, 2008, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Differential regulation of type‐II and type‐X collagen synthesis by parathyroid hormone‐related protein in chick growth‐plate chondrocytes

J. Puzas, P. Reynolds, R. O’Keefe, 1997, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Cells Regulate Tumor Burden and Osteolysis in Bone Dependent Mechanisms in Breast Cancer − B κ Nuclear Factor-Updated

E. Schwarz, J. Puzas, R. O’Keefe, 2005 .

Effects of receptor activator of NFκB (RANK) signaling blockade on fracture healing

E. Schwarz, R. O’Keefe, W. Dougall, 2003, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Aryl hydrocarbon receptor‐mediated impairment of chondrogenesis and fracture healing by cigarette smoke and benzo(α)pyrene

R. O’Keefe, M. Zuscik, K. Yukata, 2012, Journal of cellular physiology.

Inhibition of the Prostaglandin EP-1 Receptor in Periosteum Progenitor Cells Enhances Osteoblast Differentiation and Fracture Repair

R. O’Keefe, H. Awad, Jie Shen, 2019, Annals of Biomedical Engineering.

Osterix/Sp7 regulates mesenchymal stem cell mediated endochondral ossification

E. Schwarz, R. O’Keefe, H. Drissi, 2008, Journal of cellular physiology.

Regulation of osteoclastic activity in infection.

J. Puzas, R. O’Keefe, S. Reynolds, 1994, Methods in enzymology.

Interleukin‐10 inhibits cytokine synthesis in monocytes stimulated by titanium particles: Evidence of an anti‐inflammatory regulatory pathway

J. Puzas, P. Reynolds, R. O’Keefe, 1998, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Granular Histiocytosis of Pelvic Lymph Nodes following Total Hip Arthroplasty. The Presence of Wear Debris, Cytokine Production, and Immunologically Activated Macrophages*

J. Puzas, R. O’Keefe, A. Judkins, 1996, The Journal of bone and joint surgery. American volume.

Erratum: Atypical subtrochanteric and diaphyseal femoral fractures: Report of a task force of the American Society for Bone and Mineral Research (Journal of Bone and Mineral Research (2010) 25 (2267-2294))

T. Brown, P. Geusens, H. Genant, 2011 .

NFκB: A Pivotal Transcription Factor in Prostate Cancer Metastasis to Bone

E. Schwarz, J. Puzas, R. O’Keefe, 2003, Clinical orthopaedics and related research.

Effects of transforming growth factor-β on matrix synthesis by chick growth plate chondrocytes

J. Puzas, R. O’Keefe, R. Rosier, 1988 .

Inhibition of 4-aminobutyrate aminotransferase protects against injury-induced osteoarthritis in mice.

R. O’Keefe, Taotao Xu, Cuicui Wang, 2019, JCI insight.

Modulation of the Production of Cytokines in Titanium-Stimulated Human Peripheral Blood Monocytes by Pharmacological Agents. The Role of cAMP-Mediated Signaling Mechanisms*†

J. Puzas, P. Reynolds, R. O’Keefe, 1997, The Journal of bone and joint surgery. American volume.

Delayed Fracture Healing and Increased Callus Adiposity in a C57BL/6J Murine Model of Obesity-Associated Type 2 Diabetes Mellitus

D. Chen, R. O’Keefe, L. Xing, 2014, PloS one.

Axin2 regulates chondrocyte maturation and axial skeletal development

Debbie Y. Dao, R. O’Keefe, Di Chen, 2009, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Synergistic effect of transforming growth factor β and fibroblast growth factor on DNA synthesis in chick growth plate chondrocytes

J. Puzas, R. O’Keefe, R. Rosier, 1990, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Efficacy of ex vivo OPG gene therapy in preventing wear debris induced osteolysis

E. Schwarz, J. Puzas, R. O’Keefe, 2002, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Systemic tumor necrosis factor α mediates an increase in peripheral CD11bhigh osteoclast precursors in tumor necrosis factor α–transgenic mice

E. Schwarz, R. O’Keefe, L. Xing, 2004 .

Establishment of an index with increased sensitivity for assessing murine arthritis

C. Beck, E. Schwarz, John P. Ketz, 2011, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Aberrant hypertrophy in Smad3-deficient chondrocytes is rescued by restoring TAK1-ATF-2 signaling: a potential clinical implication for osteoarthritis

E. Schwarz, R. O’Keefe, T. Sheu, 2011 .

Breakthrough in bone: the molecular mechanism of osteoclast/osteoblast coupling revealed

E. Schwarz, R. O’Keefe, 2000 .

Evidence for a Direct Role of Cyclo‐Oxygenase 2 in Implant Wear Debris‐Induced Osteolysis

E. Schwarz, R. O’Keefe, L. Xing, 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

through an oxidative stress-induced, calpain-dependent, NF-kappa B pathway

E. Schwarz, R. O’Keefe, H. Drissi, 2009 .

Sphingomyelinase mediates macrophage activation by titanium particles independent of phagocytosis: A role for free radicals, NFkB, and TNFα

E. Schwarz, R. O’Keefe, M. Darowish, 2005 .

Fibroblast-Like Synoviocytes B Regulates VCAM-1 Expression on κ NF -

R. O’Keefe, I. Sanz, S. Li, 2000 .

Regulation of Chondrocyte Differentiation

R. O’Keefe, A. Ionescu, M. Drissi, 2004 .

Bone Morphogenetic Protein 2 Activates Smad6 Gene Transcription through Bone-specific Transcription Factor Runx2*

R. O’Keefe, Di Chen, L. Xing, 2007, Journal of Biological Chemistry.

Differential effects of biologic versus bisphosphonate inhibition of wear debris‐induced osteolysis assessed by longitudinal micro‐CT

E. Schwarz, R. O’Keefe, Hiromu Ito, 2008, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

RANK Signaling Is Not Required for TNFα‐Mediated Increase in CD11bhi Osteoclast Precursors but Is Essential for Mature Osteoclast Formation in TNFα‐Mediated Inflammatory Arthritis

E. Schwarz, R. O’Keefe, L. Xing, 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Anti-TNF-α therapy as a clinical intervention for periprosthetic osteolysis

E. Schwarz, R. O’Keefe, R. Looney, 2000, Arthritis research.

Efficacy of colistin‐impregnated beads to prevent multidrug‐resistant A. baumannii implant‐associated osteomyelitis

E. Schwarz, R. O’Keefe, C. Murray, 2009, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Clinical translation and application in orthopaedics

R. O’Keefe, Chih-Hwa Chen, 2017, Journal of orthopaedic translation.

A Novel Model of Hip Femoroacetabular Impingement in Immature Rabbits Reproduces the Distinctive Head-Neck Cam Deformity

R. O’Keefe, J. Clohisy, R. Brophy, 2022, The American journal of sports medicine.

Prostaglandin E2 inhibits BMP signaling and delays chondrocyte maturation

R. O’Keefe, Tian‐Fang Li, H. Drissi, 2009, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

High Incidence of Hemiarthroplasty for Shoulder Osteoarthritis Among Recently Graduated Orthopaedic Surgeons

J. Harrast, J. Baumhauer, R. O’Keefe, 2014, Clinical orthopaedics and related research.

Assessment of the performance of engineered tissues in humans requires the development of highly sensitive and quantitative noninvasive outcome measures

K. Parker, E. Schwarz, R. O’Keefe, 2003 .

RBPj κ -dependent Notch signaling is required for articular cartilage and joint maintenance

R. O’Keefe, M. Zuscik, A. J. Mirando, 2014 .

Cloning of the chick BMP1/Tolloid cDNA and expression in skeletal tissues.

J. Puzas, P. Reynolds, R. O’Keefe, 2000, Gene.

Murine and Chicken Chondrocytes Regulate Osteoclastogenesis by Producing RANKL in Response to BMP2

R. O’Keefe, Di Chen, L. Xing, 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor

E. Schwarz, R. O’Keefe, H. Drissi, 2006, Journal of cellular physiology.

Effect of Anti‐Tumor Necrosis Factor-&agr; Gene Therapy on Wear Debris‐Induced Osteolysis

E. Schwarz, R. O’Keefe, J. Goater, 2001, The Journal of bone and joint surgery. American volume.

A Rapid Multiparameter Approach to Study Factors that Regulate Osteoclastogenesis: Demonstration of the Combinatorial Dominant Effects of TNF-α and TGF-ß in RANKL-Mediated Osteoclastogenesis

E. Schwarz, R. O’Keefe, W. Huang, 2003, Calcified Tissue International.

Teriparatide (human PTH 1–34 ) Compensates for Impaired Fracture Healing in COX-2 Deficient Mice

C. Beck, E. Schwarz, R. O’Keefe, 2018 .

In vivo prostaglandin E 2 treatment alters the bone marrow microenvironment and preferentially expands short-term hematopoietic stem cells

R. O’Keefe, L. Calvi, C. Jordan, 2009 .

COX‐2 has a Critical Role During Incorporation of Structural Bone Allografts

E. Schwarz, R. O’Keefe, Di Chen, 2006, Annals of the New York Academy of Sciences.

ATF-2 cooperates with Smad3 to mediate TGF-β effects on chondrocyte maturation

E. Schwarz, J. Puzas, R. O’Keefe, 2003 .

Unique angiogenic and vasculogenic properties of renal cell carcinoma in a xenograft model of bone metastasis are associated with high levels of vegf‐a and decreased ang‐1 expression

E. Schwarz, R. O’Keefe, E. Sampson, 2012, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Atypical femur fractures.

R. O’Keefe, S. Bukata, W. Tyler, 2014, Clinics in geriatric medicine.

Safety and efficacy of ultraviolet-a light-activated gene transduction for gene therapy of articular cartilage defects.

E. Schwarz, M. Maloney, R. O’Keefe, 2006, The Journal of bone and joint surgery. American volume.

Targeted Deletion of Minpp1 Provides New Insight into the Activity of Multiple Inositol Polyphosphate Phosphatase In Vivo

H. Chi, J. Puzas, P. Reynolds, 2000, Molecular and Cellular Biology.

Gene Expression Analysis of the Pleiotropic Effects of TGF-β1 in an In Vitro Model of Flexor Tendon Healing

E. Schwarz, R. O’Keefe, H. Awad, 2012, PloS one.

Primary lymphoma of bone. Correlation of magnetic resonance imaging features with cytokine production by tumor cells

D. Rubens, R. O’Keefe, S. Totterman, 1995, Cancer.

Bone Marrow-Derived Matrix Metalloproteinase-9 Is Associated with Fibrous Adhesion Formation after Murine Flexor Tendon Injury

E. Schwarz, R. O’Keefe, L. Calvi, 2012, PloS one.

Inhibition of beta-catenin signaling in articular chondrocytes results in articular cartilage destruction.

R. O’Keefe, Di Chen, Qiuqian Wu, 2008, Arthritis and rheumatism.

Conditional Activation of β -Catenin Signaling Leads to Severe Defects in Intervertebral Disc Tissue

E. Schwarz, R. O’Keefe, H. Im, 2013 .

Conditional activation of β-catenin signaling in mice leads to severe defects in intervertebral disc tissue.

E. Schwarz, R. O’Keefe, H. Im, 2012, Arthritis and rheumatism.

Cytokine and matrix metalloproteinase expression in pigmented villonodular synovitis may mediate bone and cartilage destruction.

R. O’Keefe, L. Teot, R. Rosier, 1998, The Iowa orthopaedic journal.

Autocrine regulation of articular cartilage.

R. O’Keefe, R. Rosier, 1998, Instructional course lectures.

The Impact of Smad3 Loss of Function on TGF-&bgr; Signaling and Radiation-Induced Capsular Contracture

H. Langstein, R. O’Keefe, Jacqueline P. Williams, 2011, Plastic and reconstructive surgery.

PGE2 inhibits chondrocyte differentiation through PKA and PKC signaling.

E. Schwarz, R. O’Keefe, Tian‐Fang Li, 2004, Experimental cell research.

CREB Cooperates with BMP‐stimulated Smad signaling to enhance transcription of the Smad6 promoter

E. Schwarz, J. Puzas, R. O’Keefe, 2004, Journal of cellular physiology.

Transforming growth factor beta: an autocrine regulator of chondrocytes.

J. Puzas, R. O’Keefe, R. Rosier, 1989, Connective tissue research.

Fibroblasts Express RANKL and Support Osteoclastogenesis in a COX‐2‐Dependent Manner After Stimulation With Titanium Particles

E. Schwarz, R. O’Keefe, M. Zuscik, 2005, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Runx3/AML2/Cbfa3 Regulates Early and Late Chondrocyte Differentiation

E. Schwarz, R. O’Keefe, H. Drissi, 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Impact of Smad3 loss of function on scarring and adhesion formation during tendon healing

H. Langstein, R. O’Keefe, W. Hammert, 2011, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Orthopaedic basic science : foundations of clinical practice

J. Buckwalter, R. O’Keefe, T. Einhorn, 2007 .

PGE2 and IL‐6 production by fibroblasts in response to titanium wear debris particles is mediated through a Cox‐2 dependent pathway

E. Schwarz, J. Puzas, R. O’Keefe, 2004, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Cyclooxygenase-2 deficiency causes delayed ossification of lumbar vertebral endplates.

J. Block, H. An, R. O’Keefe, 2018, American journal of translational research.

Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis

E. Schwarz, R. O’Keefe, M. Zuscik, 2008, Oncogene.

Parathyroid Hormone-Related Peptide Expression in Cartilaginous Tumors

R. O’Keefe, L. Teot, R. Rosier, 2002, Clinical orthopaedics and related research.

Otto Aufranc Award: Identification of Key Molecular Players in the Progression of Hip Osteoarthritis through Transcriptomes and Epigenetics.

R. O’Keefe, J. Clohisy, R. Brophy, 2022, The Journal of arthroplasty.

Scholarly Success of Orthopaedic Surgeons Participating in the Clinician Scholar Career Development Program

R. O’Keefe, A. Mesfin, P. Rubery, 2018, The Journal of bone and joint surgery. American volume.

Tamoxifen-inducible CreER-mediated gene targeting in periosteum via bone-graft transplantation.

E. Schwarz, R. O’Keefe, Xinping Zhang, 2008, The Journal of bone and joint surgery. American volume.

Demonstrating the value of orthopaedic surgery through multicenter trials: AOA critical issues.

K. Spindler, R. O’Keefe, A. Hilibrand, 2015, The Journal of bone and joint surgery. American volume.

EP1−/− Mice Have Enhanced Osteoblast Differentiation and Accelerated Fracture Repair

E. Schwarz, R. O’Keefe, T. Sheu, 2010, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

TGF- β SIGNALING IN CHONDROCYTES

R. O’Keefe, Tian‐Fang Li, 2004 .

Local and neurally mediated effects of sufentanil on canine skeletal muscle vascular resistance.

W. J. Powell, J. Guerrero, R. O’Keefe, 1987, The Journal of pharmacology and experimental therapeutics.

Alteration of femoral bone morphology and density in COX-2-/- mice.

R. Guldberg, E. Schwarz, R. O’Keefe, 2006, Bone.

Malic Enzyme 1 Absence in Synovial Sarcoma Shifts Antioxidant System Dependence and Increases Sensitivity to Ferroptosis Induction with ACXT-3102

Jason M. Held, Kevin B. Jones, T. Nielsen, 2022, Clinical cancer research : an official journal of the American Association for Cancer Research.

Smad6 is induced by BMP‐2 and modulates chondrocyte differentiation

E. Schwarz, J. Puzas, R. O’Keefe, 2003, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Inflammation and epigenetic regulation in osteoarthritis

R. O’Keefe, Y. Abu-Amer, Jie Shen, 2017, Connective tissue research.

Autoimmunity and Bone

E. Schwarz, R. O’Keefe, L. Xing, 2006, Annals of the New York Academy of Sciences.

Systemic tumor necrosis factor alpha mediates an increase in peripheral CD11bhigh osteoclast precursors in tumor necrosis factor alpha-transgenic mice.

E. Schwarz, R. O’Keefe, L. Xing, 2004, Arthritis and rheumatism.

Mycobacterium bovis osteomyelitis involving a hip arthroplasty after intravesicular bacille Calmette-Guérin for bladder cancer.

R. Betts, R. O’Keefe, C. Guerra, 1998, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Case report 830

S. Scully, R. O’Keefe, M. Gebhardt, 1994, Skeletal Radiology.

Calcific myonecrosis. A late sequela to compartment syndrome of the leg.

J. O'Connell, S. Scully, R. O’Keefe, 1995, Clinical orthopaedics and related research.

Activation of β‐Catenin Signaling in Articular Chondrocytes Leads to Osteoarthritis‐Like Phenotype in Adult β‐Catenin Conditional Activation Mice

R. O’Keefe, Di Chen, Qiuqian Wu, 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Articular Cartilage Biology

Michael D Maloney, E. Schwarz, M. Maloney, 2003, The Journal of the American Academy of Orthopaedic Surgeons.

Pharmacologic modulators of fracture healing: the role of cyclooxygenase inhibition.

J. Puzas, E. Schwarz, R. O’Keefe, 2003, Journal of musculoskeletal & neuronal interactions.

Cyclooxygenases and bone repair

E. Schwarz, R. O’Keefe, Yejia Zhang, 2001 .

The biology of the growth plate.

R. O’Keefe, Regis J O'Keefe, R Tracy Ballock, 2003, The Journal of bone and joint surgery. American volume.

Quantitative small‐animal surrogate to evaluate drug efficacy in preventing wear debris‐induced osteolysis

E M Schwarz, R N Rosier, E. Schwarz, 2000, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

The potential role of transforming growth factor beta in fracture healing.

R J O'Keefe, R N Rosier, R. O’Keefe, 1998, Clinical orthopaedics and related research.

The Surgical Treatment of Patients With Osteosarcoma Who Sustain a Pathologic Fracture

S. Scully, R. O’Keefe, M. Gebhardt, 1996, Clinical orthopaedics and related research.

Bone tissue engineering

R. O’Keefe, J. Mao, H. Awad, 2020, Principles of Tissue Engineering.

Bone Tissue Engineering: Clinical Challenges and Emergent Advances in Orthopedic and Craniofacial Surgery

R. O’Keefe, J. Mao, H. Awad, 2014 .

Functional Outcome after Soft‐Tissue Reconstruction for Limb Salvage after Sarcoma Surgery

R. O’Keefe, J. Serletti, R. Rosier, 1998, Plastic and reconstructive surgery.

Factors impacting musculoskeletal knowledge and clinical confidence in graduating medical students.

B. Digiovanni, R. O’Keefe, C. Mooney, 2014, The Journal of bone and joint surgery. American volume.

Use of volumetric computerized tomography as a primary outcome measure to evaluate drug efficacy in the prevention of peri‐prosthetic osteolysis: A 1‐year clinical pilot of etanercept vs. placebo

E. Schwarz, R. O’Keefe, S. Totterman, 2003, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Recombinant Adeno-Associated Virus-Mediated Osteoprotegerin Gene Therapy Inhibits Wear Debris-Induced Osteolysis

Kirk E. Smith, Kjeld Søballe, E. Schwarz, 2002, The Journal of bone and joint surgery. American volume.

Increased Levels of Tumor Necrosis Factor-&agr; and Interleukin-6 Protein and Messenger RNA in Human Peripheral Blood Monocytes due to Titanium Particles*

J. Puzas, P. Reynolds, R. O’Keefe, 1996, The Journal of bone and joint surgery. American volume.

PGE2 Signaling Through the EP4 Receptor on Fibroblasts Upregulates RANKL and Stimulates Osteolysis

E. Schwarz, R. O’Keefe, Xinping Zhang, 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

The Role of Muscle in Bone Repair: The Cells, Signals, and Tissue Responses to Injury

R. O’Keefe, K. Shah, J. Jonason, 2013, Current Osteoporosis Reports.

Assessment and management of the orthopedic and other complications of Proteus syndrome

Julie C. Sapp, L. Biesecker, R. O’Keefe, 2011, Journal of children's orthopaedics.

The Convergence of Fracture Repair and Stem Cells: Interplay of Genes, Aging, Environmental Factors and Disease

R. O’Keefe, M. Hadjiargyrou, 2014, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Parathyroid hormone‐related peptide regulation of chick tibial growth plate chondrocyte maturation requires protein kinase A

E. Schwarz, R. O’Keefe, M. Zuscik, 2002, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Physiology and pathophysiology of the growth plate.

R. O’Keefe, R. T. Ballock, R. Ballock, 2003, Birth defects research. Part C, Embryo today : reviews.

Effects of lead on growth plate chondrocyte phenotype.

K. Reynolds, J. Puzas, R. O’Keefe, 1996, Toxicology and applied pharmacology.

Atypical Subtrochanteric and Diaphyseal Femoral Fractures: Second Report of a Task Force of the American Society for Bone and Mineral Research

Thomas D Brown, Klaus Klaushofer, Jeffrey R Curtis, 2011, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Bone tissue engineering and regeneration: from discovery to the clinic--an overview.

Jeremy Mao, R. O’Keefe, J. Mao, 2011, Tissue engineering. Part B, Reviews.

Distinct metabolic programs induced by TGF-β1 and BMP2 in human articular chondrocytes with osteoarthritis

R. O’Keefe, Cuicui Wang, Jie Shen, 2018, Journal of orthopaedic translation.

Teriparatide as a Chondroregenerative Therapy for Injury-Induced Osteoarthritis

E. Schwarz, J. Puzas, R. O’Keefe, 2011, Science Translational Medicine.

Evaluation of dense polylactic acid/beta-tricalcium phosphate scaffolds for bone tissue engineering.

E. Schwarz, R. O’Keefe, M. Zuscik, 2010, Journal of biomedical materials research. Part A.

Overlapping expression of Runx1(Cbfa2) and Runx2(Cbfa1) transcription factors supports cooperative induction of skeletal development

G. Stein, J. Lian, E. Schwarz, 2005, Journal of cellular physiology.

Remodeling of murine intrasynovial tendon adhesions following injury: MMP and neotendon gene expression

E. Schwarz, R. O’Keefe, David J. Mitten, 2009, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Runx2-mediated regulation of the zinc finger Osterix/Sp7 gene.

E. Schwarz, R. O’Keefe, H. Drissi, 2006, Gene.

Runx2 plays a central role in Osteoarthritis development

R. O’Keefe, Di Chen, Jie Shen, 2019, Journal of orthopaedic translation.

Effects of transforming growth factor-beta on matrix synthesis by chick growth plate chondrocytes.

J. Puzas, R. O’Keefe, R. Rosier, 1988, Endocrinology.

Exposure to receptor-activator of NFκB ligand renders pre-osteoclasts resistant to IFN-γ by inducing terminal differentiation

E. Schwarz, R. O’Keefe, W. Huang, 2002, Arthritis research & therapy.

Effects of transforming growth factor‐β1 and fibroblast growth factor on DNA synthesis in growth plate chondrocytes are enhanced by insulin‐like growth factor‐I

R. O’Keefe, R. Rosier, I. D. Crabb, 1994 .

P‐glycoprotein expression in cartilaginous tumors

J. Puzas, P. Reynolds, R. O’Keefe, 1997, Journal of surgical oncology.

BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development

R. O’Keefe, Y. Mishina, Di Chen, 2011, Journal of Cell Science.

Dnmt3b ablation impairs fracture repair through upregulation of Notch pathway.

R. O’Keefe, J. Guan, Y. Abu-Amer, 2020, JCI insight.

Ablation of Dnmt3b in chondrocytes suppresses cell maturation during embryonic development

R. O’Keefe, Taotao Xu, Cuicui Wang, 2018, Journal of cellular biochemistry.

DNA methyltransferase 3b regulates articular cartilage homeostasis by altering metabolism.

John M. Ashton, Jason R. Myers, Daofeng Li, 2017, JCI insight.

BMP‐TAK1 (MAP3K7) Induces Adipocyte Differentiation Through PPARγ Signaling

R. O’Keefe, Yongchun Zhang, J. Jonason, 2017, Journal of cellular biochemistry.

Runx1/AML1/Cbfa2 Mediates Onset of Mesenchymal Cell Differentiation Toward Chondrogenesis

E. Schwarz, R. O’Keefe, H. Drissi, 2005, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

β‐catenin, cartilage, and osteoarthritis

R. O’Keefe, Di Chen, Qiuqian Wu, 2010, Annals of the New York Academy of Sciences.

Targeting Radioresistant Osteosarcoma Cells With Parthenolide

R. O’Keefe, R. Rosier, An-Hoa Giang, 2012, Journal of cellular biochemistry.

Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NFκB

E. Schwarz, R. O’Keefe, H. Drissi, 2006 .

Transcriptional regulation of chondrocyte maturation: potential involvement of transcription factors in OA pathogenesis.

R. O’Keefe, H. Drissi, M. Zuscik, 2005, Molecular aspects of medicine.

TAK1 Regulates Cartilage and Joint Development via the MAPK and BMP Signaling Pathways

E. Schwarz, R. O’Keefe, M. Hilton, 2010, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

TGF-beta signaling in chondrocytes.

R. O’Keefe, Di Chen, Tian‐Fang Li, 2005, Frontiers in bioscience : a journal and virtual library.

Analysis of type II and type X collagen synthesis in cultured growth plate chondrocytes by in situ hybridization: Rapid induction of type X collagen in culture

J. Puzas, R. O’Keefe, R. Rosier, 1994, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Mitochondrial Dysfunction and Permeability Transition in Osteosarcoma Cells Showing the Warburg Effect*

R. O’Keefe, K. L. de Mesy Bentley, P. Brookes, 2013, The Journal of Biological Chemistry.

Role of surgical resection in pelvic Ewing's sarcoma.

H J Mankin, R J O'Keefe, S. Scully, 1995, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Aberrant hypertrophy in Smad3-deficient murine chondrocytes is rescued by restoring transforming growth factor beta-activated kinase 1/activating transcription factor 2 signaling: a potential clinical implication for osteoarthritis.

E. Schwarz, R. O’Keefe, Y. Konttinen, 2010, Arthritis and rheumatism.

Reduced COX-2 Expression in Aged Mice Is Associated With Impaired Fracture Healing

Hicham Drissi, Hani Awad, R. Guldberg, 2008, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Safety of Overlapping Inpatient Orthopaedic Surgery: A Multicenter Study

Alan L. Zhang, A. Presson, M. Maloney, 2018, The Journal of bone and joint surgery. American volume.

Differential expression of biological effects in maturationally distinct subpopulations of growth plate chondrocytes.

J. Puzas, R. O’Keefe, R. Rosier, 1990, Connective tissue research.

Countercurrent centrifugal elutriation. High-resolution method for the separation of growth-plate chondrocytes.

J. Puzas, R. O’Keefe, R. Rosier, 1989, The Journal of bone and joint surgery. American volume.

Inflammatory Response of Articular Cartilage to Femoroacetabular Impingement in the Hip

R. O’Keefe, J. Clohisy, R. Brophy, 2020, The American journal of sports medicine.

Smurf2 induces degradation of GSK-3beta and upregulates beta-catenin in chondrocytes: a potential mechanism for Smurf2-induced degeneration of articular cartilage.

R. O’Keefe, Di Chen, Qiuqian Wu, 2009, Experimental cell research.

Forum on bone and skeletal muscle interactions: Summary of the proceedings of an ASBMR workshop

D. Kiel, K. Esser, L. Bonewald, 2013, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Growth plate chondrocyte maturation is regulated by basal intracellular calcium.

E. Schwarz, M. D'souza, J. Puzas, 2002, Experimental cell research.

Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy

Hiromu Ito, Brendan F Boyce, Kirill Gromov, 2005, Nature Medicine.

Runx2/Cbfa1 stimulation by retinoic acid is potentiated by BMP2 signaling through interaction with Smad1 on the collagen X promoter in chondrocytes

E. Schwarz, J. Puzas, R. O’Keefe, 2003, Journal of cellular biochemistry.

Parathyroid hormone-related peptide (PTHrP) inhibits Runx2 expression through the PKA signaling pathway.

E. Schwarz, R. O’Keefe, Tian‐Fang Li, 2004, Experimental cell research.

Lead alters parathyroid hormone‐related peptide and transforming growth factor‐β1 effects and AP‐1 and NF‐κKB signaling in chondrocytes

E. Schwarz, J. Puzas, R. O’Keefe, 2002, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

PTHrP expression in chick sternal chondrocytes is regulated by TGF‐β through Smad‐mediated signaling

E. Schwarz, J. Puzas, R. O’Keefe, 2001, Journal of cellular physiology.

PTHrP Modulates Chondrocyte Differentiation through AP-1 and CREB Signaling*

C. Vinson, E. Schwarz, J. Puzas, 2001, The Journal of Biological Chemistry.

PTHrP expression in chondrocytes, regulation by TGF-beta, and interactions between epiphyseal and growth plate chondrocytes.

M. D'souza, J. Puzas, E. Schwarz, 2000, Experimental cell research.

Bone morphogenetic protein‐7 in growth‐plate chondrocytes: Regulation by retinoic acid is dependent on the stage of chondrocyte maturation

C. Grimsrud, J. Puzas, P. Reynolds, 1998, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

TNFα and pathologic bone resorption

E. Schwarz, R. O’Keefe, L. Xing, 2005 .

BMP‐6 Is an Autocrine Stimulator of Chondrocyte Differentiation

C. Grimsrud, M. D'souza, J. Puzas, 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Increased radiation‐induced apoptosis of Saos2 cells via inhibition of NFκB: A role for c‐Jun N‐terminal kinase

E. Schwarz, R. O’Keefe, H. Drissi, 2005, Journal of Cellular Biochemistry.

The histone deacetylase inhibitor vorinostat selectively sensitizes fibrosarcoma cells to chemotherapy

E. Schwarz, R. O’Keefe, E. Sampson, 2011, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

The Mevalonate Synthesis Pathway as a Therapeutic Target in Cancer

E. Schwarz, R. O’Keefe, R. Rosier, 2003, Clinical orthopaedics and related research.

Quantitative mouse model of implant‐associated osteomyelitis and the kinetics of microbial growth, osteolysis, and humoral immunity

E. Schwarz, J. Puzas, R. O’Keefe, 2008, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Effects of antiresorptive agents on osteomyelitis

E. Schwarz, R. O’Keefe, L. Xing, 2010, Annals of the New York Academy of Sciences.

Freeze-dried tendon allografts as tissue-engineering scaffolds for Gdf5 gene delivery.

Kjeld Søballe, Hani A Awad, Justin Jacobson, 2008, Molecular therapy : the journal of the American Society of Gene Therapy.

Volumetric computerized tomography as a measurement of periprosthetic acetabular osteolysis and its correlation with wear

Jose Tamez-Pena, Saara Totterman, E. Schwarz, 2001, Arthritis research.

Regulation of chondrogenesis and chondrocyte differentiation by stress.

R. O’Keefe, M. Zuscik, M. Hilton, 2008, The Journal of clinical investigation.

The molecular pathophysiology of subacromial bursitis in rotator cuff disease.

Francis Y. Lee, R. Winchester, R. O’Keefe, 2005, Journal of shoulder and elbow surgery.

Factors Associated With Early Improvement in Low Back Pain After Total Hip Arthroplasty: A Multi-Center Prospective Cohort Analyses.

P. Franklin, R. O’Keefe, Wenjun Li, 2016, The Journal of arthroplasty.

Proinflammatory cytokines and metalloproteases are expressed in the subacromial bursa in patients with rotator cuff disease.

M. Maloney, R. O’Keefe, L. Bigliani, 2005, Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association.

Cellular and Molecular Factors in Flexor Tendon Repair and Adhesions: A Histological and Gene Expression Analysis

Hani A Awad, E. Schwarz, R. O’Keefe, 2013, Connective tissue research.

Development of antisense oligonucleotide (ASO) technology against Tgf‐β signaling to prevent scarring during flexor tendon repair

Hani A Awad, R. O’Keefe, H. Awad, 2015, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

TGF‐β1 Suppresses Plasmin and MMP Activity in Flexor Tendon Cells via PAI‐1: Implications for Scarless Flexor Tendon Repair

E. Schwarz, R. O’Keefe, H. Awad, 2015, Journal of cellular physiology.

Systemic EP4 Inhibition Increases Adhesion Formation in a Murine Model of Flexor Tendon Repair

R. O’Keefe, W. Hammert, H. Awad, 2015, PloS one.

Periprosthetic osteolysis: an immunologist's update

E. Schwarz, R. O’Keefe, R. Looney, 2006, Current opinion in rheumatology.

E. Schwarz, J. Puzas, P. Reynolds, 2000, Endocrinology.

The orally bioavailable met inhibitor PF‐2341066 inhibits osteosarcoma growth and osteolysis/matrix production in a xenograft model

E. Schwarz, R. O’Keefe, E. Sampson, 2011, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

The Role of Autocrine Growth Factors in Radiation Damage to the Epiphyseal Growth Plate

P. Okunieff, L. Constine, E. Schwarz, 2001, Radiation research.

In vivo prostaglandin E2 treatment alters the bone marrow microenvironment and preferentially expands short-term hematopoietic stem cells.

R. O’Keefe, L. Calvi, C. Jordan, 2009, Blood.

LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis

R. O’Keefe, K. Ke, Manoj Arra, 2020, Nature Communications.

Case report 830: Aneurysmal bone cyst.

S. Scully, R. O’Keefe, M. Gebhardt, 1994, Skeletal radiology.

Gene polymorphisms and musculoskeletal disease

E. Schwarz, R. O’Keefe, W. Huang, 2001 .

Extraosseous primary and recurrent giant cell tumors: transforming growth factor-beta1 and -beta2 expression may explain metaplastic bone formation.

J. O'Connell, R. O’Keefe, David G. Hicks, 1996, Human pathology.

Influence of prostaglandins on DNA and matrix synthesis in growth plate chondrocytes

J. Puzas, R. O’Keefe, R. Rosier, 1992, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Molecular biology and therapeutics in musculoskeletal oncology.

R. O’Keefe, R. Randall, T. Guise, 2009, The Journal of bone and joint surgery. American volume.

RNA-Seq analysis of chondrocyte transcriptome reveals genetic heterogeneity in LG/J and SM/J murine strains.

J. Cheverud, R. O’Keefe, E. Tycksen, 2020, Osteoarthritis and cartilage.

Cartilage‐specific β‐catenin signaling regulates chondrocyte maturation, generation of ossification centers, and perichondrial bone formation during skeletal development

Debbie Y. Dao, R. O’Keefe, W. Hsu, 2012, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

The orthopaedic genome: what does the future hold and are we ready?

J. Puzas, R. O’Keefe, J. Lieberman, 2002, The Journal of bone and joint surgery. American volume.

Cartilage-specific RBPjκ-dependent and -independent Notch signals regulate cartilage and bone development

T. Honjo, R. O’Keefe, M. Zuscik, 2012, Development.

Axin2 controls bone remodeling through the β-catenin–BMP signaling pathway in adult mice

J. Puzas, R. O’Keefe, X. Tan, 2009, Journal of Cell Science.

Bone density changes after radiation for extremity sarcomas: exploring the etiology of pathologic fractures.

L. Constine, R. O’Keefe, R. Rosier, 2011, International journal of radiation oncology, biology, physics.

NFκB: a pivotal transcription factor in prostate cancer metastasis to bone1

E. Schwarz, J. Puzas, R. O’Keefe, 2004 .

COX‐1 and COX‐2 expression in osteoid osteomas

E. Schwarz, J. Puzas, R. O’Keefe, 2002, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Atypical subtrochanteric and diaphyseal femoral fractures: Report of a task force of the American Society for Bone and Mineral Research

T. Brown, P. Geusens, H. Genant, 2011 .

Autoimmunity and Bone

E. Schwarz, R. O’Keefe, L. Xing, 2006, Annals of the New York Academy of Sciences.

Transforming growth factor-beta stimulates cyclin D1 expression through activation of beta-catenin signaling in chondrocytes.

E. Schwarz, R. O’Keefe, Di Chen, 2006, The Journal of biological chemistry.

Malignant reversion of a human osteosarcoma cell line, Saos-2, by inhibition of NFkappaB.

E. Schwarz, R. O’Keefe, T. Sheu, 2002, Biochemical and biophysical research communications.

Retinoic acid stimulates chondrocyte differentiation and enhances bone morphogenetic protein effects through induction of Smad1 and Smad5.

E. Schwarz, J. Puzas, R. O’Keefe, 2003, Endocrinology.

Lead Induces Chondrogenesis and Alters Transforming Growth Factor-β and Bone Morphogenetic Protein Signaling in Mesenchymal Cell Populations

E. Schwarz, J. Puzas, R. O’Keefe, 2007, Environmental health perspectives.

Ski inhibits TGF‐β/phospho‐Smad3 signaling and accelerates hypertrophic differentiation in chondrocytes

R. O’Keefe, Di Chen, H. Drissi, 2012, Journal of cellular biochemistry.

BMP-2 induces ATF4 phosphorylation in chondrocytes through a COX-2/PGE2 dependent signaling pathway.

R. O’Keefe, W. Hsu, Y. Konttinen, 2014, Osteoarthritis and cartilage.

Giant Cell Tumor of Bone in the Foot and Ankle

S. Scully, R. O’Keefe, R. O'Donnell, 1995, Foot & ankle international.

How do you know it is true? Integrity in research and publications: AOA critical issues.

Joseph A Buckwalter, Vernon T Tolo, J. Buckwalter, 2015, The Journal of bone and joint surgery. American volume.

Digital Commons@Becker How do you know it is true? Integrity in research and publications

Joseph A. Buckwalter, J. Buckwalter, R. O’Keefe, 2014 .

Peripheral Blood Stem Cell Therapy Does Not Improve Outcomes of Femoral Head Osteonecrosis With Cap‐Shaped Separated Cartilage Defect

R. O’Keefe, Di Chen, Jie Shen, 2020, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

What experimental approaches (eg, in vivo, in vitro, tissue retrieval) are effective in investigating the biologic effects of particles?

R. O’Keefe, M. Bostrom, 2008, The Journal of the American Academy of Orthopaedic Surgeons.

Clinical relevance of increased retinoid and cAMP transcriptional programs in tumor cells rendered non-malignant by dominant negative inhibition of NFkappaB.

E. Schwarz, R. O’Keefe, R. Rosier, 2003, Cancer letters.

Reduction of particle-induced osteolysis by interleukin-6 involves anti-inflammatory effect and inhibition of early osteoclast precursor differentiation.

E. Schwarz, R. O’Keefe, Ping Li, 2009, Bone.

Clinical Outcome of 38 Patients With Juxtacortical Osteosarcoma

S. Scully, R. O’Keefe, H. Temple, 2000, Clinical orthopaedics and related research.

ALK2 Functions as a BMP Type I Receptor and Induces Indian Hedgehog in Chondrocytes During Skeletal Development

E. Schwarz, J. Puzas, R. O’Keefe, 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis

R. O’Keefe, K. Ke, Manoj Arra, 2020, Nature Communications.

Variation in the Delivery of Inpatient Orthopaedic Care to Medicaid Beneficiaries within a Single Metropolitan Region.

R. O’Keefe, M. Olsen, C. Dy, 2019, The Journal of bone and joint surgery. American volume.

5‐azacytidine alters TGF‐β and BMP signaling and induces maturation in articular chondrocytes

E. Schwarz, J. Puzas, R. O’Keefe, 2004, Journal of cellular biochemistry.

Transforming growth factor-beta and Wnt signals regulate chondrocyte differentiation through Twist1 in a stage-specific manner.

E. Schwarz, R. O’Keefe, H. Drissi, 2007, Molecular endocrinology.

Self-complementary AAV2.5-BMP2-coated femoral allografts mediated superior bone healing versus live autografts in mice with equivalent biomechanics to unfractured femur.

E. Schwarz, R. O’Keefe, R. Samulski, 2011, Molecular therapy : the journal of the American Society of Gene Therapy.

Embracing Differences to Improve Success: American Orthopaedic Association Presidential Address, Boston, Massachusetts, June 23, 2017: AOA Critical Issues.

R. O’Keefe, 2019, The Journal of bone and joint surgery. American volume.

Differential effects of parathyroid hormone on chick growth plate and articular chondrocytes

J. Puzas, R. O’Keefe, R. Rosier, 2004, Calcified Tissue International.

Micro-computed tomography prediction of biomechanical strength in murine structural bone grafts.

Amy L Lerner, Hani A Awad, Justin Jacobson, 2007, Journal of biomechanics.

Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NFkappaB.

E. Schwarz, R. O’Keefe, H. Drissi, 2006, Experimental cell research.

A novel murine segmental femoral graft model

E. Schwarz, R. O’Keefe, P. Tiyapatanaputi, 2004, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Semi-automated CT-based analysis of regional bone-density in contra lateral total hip replacement

Monica Barbu-McInnis, Jose Tamez-Pena, Therese Crilly, 2004, SPIE Medical Imaging.

Notch signaling in postnatal joint chondrocytes, but not subchondral osteoblasts, is required for articular cartilage and joint maintenance.

R. O’Keefe, M. Zuscik, Y. Ren, 2016, Osteoarthritis and cartilage.

Deletion of Glut1 in early postnatal cartilage reprograms chondrocytes toward enhanced glutamine oxidation

R. O’Keefe, G. Patti, Xiangfeng Niu, 2021, Bone Research.

Transient gamma-secretase inhibition accelerates and enhances fracture repair likely via Notch signaling modulation.

Jason A Inzana, R. O’Keefe, H. Awad, 2015, Bone.

Isolation and culture of neonatal mouse calvarial osteoblasts.

R. O’Keefe, J. Jonason, 2014, Methods in molecular biology.

Epigenetic and therapeutic implications of dnmt3b in temporomandibular joint osteoarthritis.

R. O’Keefe, Xuedong Zhou, J. Mao, 2019, American journal of translational research.

Use of a Phage Display Technique to Identify Potential Osteoblast Binding Sites Within Osteoclast Lacunae

E. Schwarz, J. Puzas, R. O’Keefe, 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

A Phage Display Technique Identifies a Novel Regulator of Cell Differentiation*

E. Schwarz, J. Puzas, R. O’Keefe, 2003, The Journal of Biological Chemistry.

Endogenous tissue engineering: PTH therapy for skeletal repair

E. Schwarz, R. O’Keefe, H. Awad, 2012, Cell and Tissue Research.

NOTCH‐Mediated Maintenance and Expansion of Human Bone Marrow Stromal/Stem Cells: A Technology Designed for Orthopedic Regenerative Medicine

R. O’Keefe, Cuicui Wang, M. Hilton, 2014, Stem cells translational medicine.

Synergism of Aminobisphosphonates and Farnesyl Transferase Inhibitors on Tumor Metastasis

E. Schwarz, R. O’Keefe, R. Rosier, 2002, Clinical orthopaedics and related research.

The role of p105 protein in NFκB activation in ANA‐1 murine macrophages following stimulation with titanium particles

E. Schwarz, R. O’Keefe, S. Nedospasov, 2002, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Molecular mechanisms of bone metastasis and therapeutic implications.

R. O’Keefe, T. Guise, 2003, Clinical orthopaedics and related research.

A genome‐wide expression profile and system‐level integration of nuclear factor kappa B regulated genes reveals fundamental metabolic adaptations during cell growth and survival

E. Schwarz, R. O’Keefe, R. Rosier, 2005, FEBS letters.

Rescue of impaired fracture healing in COX-2-/- mice via activation of prostaglandin E2 receptor subtype 4.

R. Guldberg, E. Schwarz, R. O’Keefe, 2009, The American journal of pathology.

P38-ATF2 Signaling Regulates Chondrocyte Maturation: the potential novel therapeutics for osteoarthritis

E. Schwarz, R. O’Keefe, M. Zuscik, 2006 .

Teriparatide therapy and beta-tricalcium phosphate enhance scaffold reconstruction of mouse femoral defects.

E. Schwarz, R. O’Keefe, M. Zuscik, 2011, Tissue engineering. Part A.

Did the Physical and Mental Health of Orthopaedic Patients Change After the Onset of the COVID-19 Pandemic?

R. O’Keefe, R. Calfee, E. Yanik, 2023, Clinical orthopaedics and related research.

Tamoxifen-inducible Cre-recombination in articular chondrocytes of adult Col2a1-CreER(T2) transgenic mice.

R. O’Keefe, Mo Chen, A. Lichtler, 2008, Osteoarthritis and cartilage.

COX-2 from the injury milieu is critical for the initiation of periosteal progenitor cell mediated bone healing.

R. Guldberg, E. Schwarz, R. O’Keefe, 2008, Bone.

CCN1 Regulates Chondrocyte Maturation and Cartilage Development

R. O’Keefe, T. Sheu, M. Zuscik, 2016, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Functional integration of tissue-engineered bone constructs.

R E Guldberg, M Oest, A S P Lin, 2004, Journal of musculoskeletal & neuronal interactions.

Primary murine growth plate and articular chondrocyte isolation and cell culture.

R. O’Keefe, J. Jonason, Donna Hoak, 2015, Methods in molecular biology.

Osteoclasts constitutively express regulators of bone resorption: an immunohistochemical and in situ hybridization study.

J. Puzas, R. O’Keefe, L. Teot, 1997, Laboratory investigation; a journal of technical methods and pathology.

Shared phenotypic expression of osteoblasts and chondrocytes in fracture callus

A. Krasinskas, R. O’Keefe, S. Hurwitz, 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Patient Report Improves Posthospital Discharge Event Capture in Total Joint Replacement: A Novel Approach to Capturing All Posthospital Event Data

J. Allison, R. O’Keefe, V. Pellegrini, 2014, EGEMS.

Fibrinolysis as a Target to Enhance Fracture Healing.

R. O’Keefe, 2015, The New England journal of medicine.

RANK, RANKL and OPG in inflammatory arthritis and periprosthetic osteolysis.

E. Schwarz, R. O’Keefe, C. Ritchlin, 2004, Journal of musculoskeletal & neuronal interactions.

Multiple drug resistance in osteosarcoma.

J. Puzas, R. O’Keefe, L. Teot, 1995, The Iowa orthopaedic journal.

Inhibition of the Prostaglandin EP-1 Receptor in Periosteum Progenitor Cells Enhances Osteoblast Differentiation and Fracture Repair

R. O’Keefe, H. Awad, Jie Shen, 2019, Annals of Biomedical Engineering.

Effects of transforming growth factor-beta 1 and fibroblast growth factor on DNA synthesis in growth plate chondrocytes are enhanced by insulin-like growth factor-I.

J. Puzas, R. O’Keefe, R. Rosier, 1994, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Epigenetic dysregulation of articular cartilage during progression of hip femoroacetabular impingement disease

R. O’Keefe, J. Clohisy, R. Brophy, 2023, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Prostaglandin E2 (PGE2) Treatment Rapidly Increases the Fraction of Non-Dividing Hematopoietic Stem Cells (HSCs)

R. O’Keefe, L. Calvi, Benjamin J. Frisch, 2008 .

Orthopaedic basic science: Foundations of clinical practice, fourth edition

Joshua J. Jacobs, Regis J. O'Keefe, Constance R. Chu, 2018 .

In vivo gene delivery to articular chondrocytes mediated by an adeno‐associated virus vector

E. Schwarz, E. Schwarz, R. O’Keefe, 2004, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Receptor activator of nuclear ??B ligand and osteoprotegerin: where are we now and what about future treatment uses?

E. Schwarz, R. O’Keefe, L. Xing, 2005 .

ATF-2 cooperates with Smad3 to mediate TGF-beta effects on chondrocyte maturation.

E. Schwarz, J. Puzas, R. O’Keefe, 2003, Experimental cell research.

Identification and characterization of a unique chondrocyte gene involved in transition to hypertrophy.

J. Puzas, P. Reynolds, R. O’Keefe, 1996, Experimental cell research.

Bone implant interface, osteolysis and potential therapies.

E. Schwarz, R. O’Keefe, R. Looney, 2004, Journal of musculoskeletal & neuronal interactions.

Immunohistochemical study of receptor activator of nuclear factor kappa‐B ligand (RANK‐L) in human osteolytic bone tumors

E. Schwarz, J. Puzas, R. O’Keefe, 2002, Journal of surgical oncology.

NF-kappa B regulates VCAM-1 expression on fibroblast-like synoviocytes.

E. Schwarz, R. O’Keefe, I. Sanz, 2000, Journal of immunology.

Sphingomyelinase mediates macrophage activation by titanium particles independent of phagocytosis: A role for free radicals, NFkB, and TNFα

E. Schwarz, R. O’Keefe, M. Darowish, 2005 .

Periosteal stem cells are essential for bone revitalization and repair.

R. Guldberg, R. O’Keefe, H. Awad, 2005, Journal of musculoskeletal & neuronal interactions.

Current concepts review: The biology of the growth plate

R. O’Keefe, R. T. Ballock, 2003 .

Murine Model of Oligotrophic Tibial Nonunion

R. O’Keefe, Z. Yaseen, Catherine A. Humphrey, 2011, Journal of orthopaedic trauma.

μCT‐Based Measurement of Cortical Bone Graft‐to‐Host Union

M. O. Papuga, E. Schwarz, R. O’Keefe, 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Distinct Pattern of Inflammation of Articular Cartilage and the Synovium in Early and Late Hip Femoroacetabular Impingement

R. O’Keefe, J. Clohisy, R. Brophy, 2020, The American journal of sports medicine.

On the Horizon From the ORS

R. O’Keefe, C. McDevitt, K. Leach, 2006 .

Bone Morphogenetic Regulation Protein-7 in by Retinoic Growth-Plate Chondrocytes: Acid is Dependent on the Stage of Chondrocyte Maturation

C. Grimsrud, J. Puzas, P. Reynolds, 2004 .

Treatment of intra-articular hip malignancy with extra-articular resection, preservation of the acetabular columns, and total hip arthroplasty

R. O’Keefe, J. Clohisy, J. Wells, 2018, Arthroplasty today.

Clinician-directed treatment guidelines

R. O’Keefe, L. Qin, Chelsea Hopkins, 2019, Journal of Orthopaedic Translation.

IN SITU HYBRIDIZATION IN SKELETAL TISSUES UTILIZING NON-RADIOACTIVE PROBES

R. O’Keefe, L. Teot, D. Hicks, 1997 .

Loss of the PGE2 receptor EP1 enhances bone acquisition, which protects against age and ovariectomy-induced impairments in bone strength.

E. Schwarz, R. O’Keefe, T. Sheu, 2015, Bone.

Teriparatide as a Chondroregenerative Therapy for Injury-Induced Osteoarthritis

E. Schwarz, J. Puzas, R. O’Keefe, 2011, Science Translational Medicine.

Teriparatide (1‐34 human PTH) regulation of osterix during fracture repair

E. Schwarz, R. O’Keefe, H. Drissi, 2008, Journal of cellular biochemistry.

Inhibition of the Wnt-β-catenin and Notch signaling pathways sensitizes osteosarcoma cells to chemotherapy.

R. O’Keefe, Y. Konttinen, Di Chen, 2013, Biochemical and biophysical research communications.

Rescue of impaired fracture healing in COX-2-/- mice via activation of prostaglandin E2 receptor subtype 4.

R. Guldberg, E. Schwarz, R. O’Keefe, 2009, The American journal of pathology.

Short-term and Long-term Orthopaedic Issues in Patients With Fragility Fractures

S. Kates, R. O’Keefe, S. Bukata, 2011, Clinical orthopaedics and related research.

Impact of Smad3 loss of function on scarring and adhesion formation during tendon healing

H. Langstein, R. O’Keefe, W. Hammert, 2011, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Hyaluronic acid therapy.

R. O’Keefe, R. Rosier, 2000, Instructional course lectures.

Patient-Reported Outcomes Measurement Information System physical function correlates with Toronto Extremity Salvage Score in an orthopaedic oncology population☆☆☆

R. O’Keefe, D. McDonald, R. Calfee, 2019, Journal of orthopaedic translation.

Atypical subtrochanteric and diaphyseal femoral fractures: Report of a task force of the american society for bone and mineral Research

T. Brown, P. Geusens, H. Genant, 2010, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Axin2 controls bone remodeling through the β-catenin–BMP signaling pathway in adult mice

J. Puzas, R. O’Keefe, X. Tan, 2009, Journal of Cell Science.

Axin2 regulates chondrocyte maturation and axial skeletal development

Debbie Y. Dao, R. O’Keefe, Di Chen, 2009, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Ablation of Dnmt3b in chondrocytes suppresses cell maturation during embryonic development

R. O’Keefe, Taotao Xu, Cuicui Wang, 2018, Journal of cellular biochemistry.

TGF‐β1 Suppresses Plasmin and MMP Activity in Flexor Tendon Cells via PAI‐1: Implications for Scarless Flexor Tendon Repair

E. Schwarz, R. O’Keefe, H. Awad, 2015, Journal of cellular physiology.

μCT‐Based Measurement of Cortical Bone Graft‐to‐Host Union

M. O. Papuga, E. Schwarz, R. O’Keefe, 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.