D. Lawrence

发表

Synergies and Coincidence Requirements between NO, cGMP, and Ca2+ in the Induction of Cerebellar Long-Term Depression

R. Tsien, V. Lev-Ram, T. Jiang, 1997, Neuron.

Development of a protease-resistant reporter to quantify BCR-ABL activity in intact cells.

N. Allbritton, C. Sims, D. Lawrence, 2016, The Analyst.

Nonphosphorylatable Tyrosine Surrogates

D. Lawrence, J. Niu, 1997, The Journal of Biological Chemistry.

Is Protein Kinase Substrate Efficacy a Reliable Barometer for Successful Inhibitor Design? (*)

D. Lawrence, D. Werner, T. R. Lee, 1996, The Journal of Biological Chemistry.

Selection and optimization of enzyme reporters for chemical cytometry.

N. Allbritton, D. Lawrence, Angela Proctor, 2019, Methods in enzymology.

Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design.

D S Lawrence, S. Almo, D. Lawrence, 1997, Proceedings of the National Academy of Sciences of the United States of America.

On Command Drug Delivery via Cell-Conveyed Phototherapeutics.

Emilia M. Zywot, D. Lawrence, P. Dayton, 2019, Small.

Src Kinase Regulation in Progressively Invasive Cancer

N. Allbritton, D. Lawrence, Weichen Xu, 2012, PloS one.

Signaling protein inhibitors via the combinatorial modification of peptide scaffolds.

D. Lawrence, 2005, Biochimica et Biophysica Acta.

Light-mediated liberation of enzymatic activity: "small molecule" caged protein equivalents.

D. Lawrence, Haishan Li, J. Hah, 2008, Journal of the American Chemical Society.

Compartmentalized cAMP Generation by Engineered Photoactivated Adenylyl Cyclases.

D. Lawrence, Lauren L Haar, Brianna M. Vickerman, 2019, Cell chemical biology.

Design and Application of Sensors for Chemical Cytometry.

Brae V. Petersen, N. Allbritton, D. Lawrence, 2018, ACS chemical biology.

High yield synthesis of 5,15-diarylporphyrins

D. Lawrence, J. Maňka, 1989 .

Substrate specificity of cyclic amp dependent protein kinase

D. Lawrence, M. Prorok, 1988 .

Stepwise Combinatorial Evolution of Akt Bisubstrate Inhibitors

D. Lawrence, Sanjai Kumar, J. H. Lee, 2008, Chembiochem : a European journal of chemical biology.

Small molecule approach to studying protein tyrosine phosphatase.

D. Lawrence, Sanjai Kumar, Zhon-Yin Zhang, 2005, Methods.

A biosensor of S100A4 metastasis factor activation: inhibitor screening and cellular activation dynamics.

K. Hahn, D. Lawrence, A. Bresnick, 2008, Biochemistry.

Cofilin Promotes Actin Polymerization and Defines the Direction of Cell Motility

John S. Condeelis, David S. Lawrence, D. Lawrence, 2004, Science.

Optogenetic engineering: light-directed cell motility.

D. Lawrence, R. M. Hughes, R. Hughes, 2014, Angewandte Chemie.

A new strategy for caging proteins regulated by kinases.

D. Lawrence, J. Condeelis, Xiaoyan Song, 2002, Journal of the American Chemical Society.

Deep quench: an expanded dynamic range for protein kinase sensors.

D. Lawrence, Vyas Sharma, R. S. Agnes, 2007, Journal of the American Chemical Society.

Protein kinase inhibitors: the tyrosine-specific protein kinases.

D. Lawrence, J. Niu, 1998, Pharmacology & therapeutics.

Structural genomics of protein phosphatases

A. Sali, J. M. Sauder, A. Fiser, 2007, Journal of Structural and Functional Genomics.

Long-wavelength fluorescent reporters for monitoring protein kinase activity.

D. Lawrence, Melanie A. Priestman, Luong T Nguyen, 2014, Angewandte Chemie.

A strategy for the construction of caged diols using a photolabile protecting group.

D. Lawrence, Weiying Lin, 2002, The Journal of organic chemistry.

A broad spectrum dark quencher: construction of multiple colour protease and photolytic sensors.

D. Lawrence, F. Jernigan, 2013, Chemical communications.

Tunable visible and near-IR photoactivation of light-responsive compounds by using fluorophores as light-capturing antennas.

Jennifer R. Shell, D. Lawrence, Thomas A. Shell, 2014, Angewandte Chemie.

A light-activated probe of intracellular protein kinase activity.

D. Lawrence, W. F. Veldhuyzen, Quan Nguyen, 2003, Journal of the American Chemical Society.

Dual wavelength photoactivation of cAMP- and cGMP-dependent protein kinase signaling pathways.

D. Lawrence, Melanie A. Priestman, Liang Sun, 2011, ACS chemical biology.

Metabolism of peptide reporters in cell lysates and single cells.

N. Allbritton, D. Lawrence, Angela Proctor, 2012, The Analyst.

Visual snapshots of intracellular kinase activity at the onset of mitosis.

D. Lawrence, A. Bresnick, N. Dulyaninova, 2007, Chemistry & biology.

The specificity of the protein kinase C α, βII and γ isoforms as assessed by an unnatural alcohol-appended peptide library

D. Lawrence, K. Curley, Xiongwei Yan, 2000 .

Increased hypothalamic protein tyrosine phosphatase 1B contributes to leptin resistance with age.

D. Lawrence, W. Cefalu, T. Gettys, 2007, Endocrinology.

Simultaneous fluorescent monitoring of proteasomal subunit catalysis.

D. Lawrence, Marion Schmidt, A. Toutchkine, 2010, Journal of the American Chemical Society.

Light-regulated sampling of protein tyrosine kinase activity.

D. Lawrence, S. Cahill, Qunzhao Wang, 2006, Journal of the American Chemical Society.

Caged regulators of signaling pathways.

D. Lawrence, K. Curley, 1999, Pharmacology & therapeutics.

Light-activated proteins.

D. Lawrence, K. Curley, Kieran Curley, 1999, Current opinion in chemical biology.

Light-mediated spatial control via photolabile fluorescently quenched peptide cassettes.

D. Lawrence, Melanie A. Priestman, Hsien-Ming Lee, 2010, Journal of the American Chemical Society.

Acquisition of Fyn-selective SH3 domain ligands via a combinatorial library strategy.

D. Lawrence, Haishan Li, 2005, Chemistry & biology.

The Role of Protein-tyrosine Phosphatase 1B in Integrin Signaling*

D. Lawrence, Zhon-Yin Zhang, F. Liang, 2005, Journal of Biological Chemistry.

Precision Targeting of Protein Kinases

D. Lawrence, J. Corbin, S. Francis, 1996, The Journal of Biological Chemistry.

Monitoring of protein arginine deiminase activity by using fluorescence quenching: multicolor visualization of citrullination.

D. Lawrence, Melanie A. Priestman, Qunzhao Wang, 2013, Angewandte Chemie.

Peptide-based fluorescent sensors of protein kinase activity: design and applications.

D. Lawrence, Qunzhao Wang, Vyas Sharma, 2008, Biochimica et biophysica acta.

Aurintricarboxylic Acid Blocks in Vitro and in Vivo Activity of YopH, an Essential Virulent Factor of Yersinia pestis, the Agent of Plague*

A. Alonso, T. Mustelin, D. Lawrence, 2003, Journal of Biological Chemistry.

An improved synthesis of tetramesitylporphyrin

D. Lawrence, R. Wagner, J. Lindsey, 1987 .

Multicolor monitoring of dysregulated protein kinases in chronic myelogenous leukemia.

D. Lawrence, Qunzhao Wang, L. Graves, 2010, ACS chemical biology.

Uber-responsive peptide-based sensors of signaling proteins.

D. Lawrence, Vyas Sharma, 2009, Angewandte Chemie.

The Active Site Specificity of the Yersinia Protein-tyrosine Phosphatase (*)

D. Lawrence, Zhon-Yin Zhang, D. Dunn, 1996, The Journal of Biological Chemistry.

Construction of a photoactivatable profluorescent enzyme via propinquity labeling.

D. Lawrence, Weichen Xu, Hsien-Ming Lee, 2011, Journal of the American Chemical Society.

The design of peptide-based substrates for the cdc2 protein kinase.

D. Lawrence, M. Koszelak, Y. Kwon, 1995, The Biochemical journal.

The Extraordinary Active Site Substrate Specificity of pp60c−src

D. Lawrence, J. Niu, T. R. Lee, 1995, The Journal of Biological Chemistry.

The active site substrate specificity of protein kinase C.

D. Lawrence, Y. Kwon, M. Mendelow, 1994, The Journal of biological chemistry.

The active site substrate specificity of the cAMP-dependent protein kinase.

D. Lawrence, T. R. Lee, S. Pluskey, 1993, The Journal of biological chemistry.

Catalytic and regulatory domains of doublecortin kinase-1.

Sandip K. Nandy, A. Edelman, D. Lawrence, 2003, Biochemistry.

Spatially discrete, light-driven protein expression.

D. Lawrence, C. Albanese, R. Pestell, 2002, Chemistry & biology.

Probing the Molecular Basis for Potent and Selective Protein-tyrosine Phosphatase 1B Inhibition*

D. Lawrence, F. Wang, Zhon-Yin Zhang, 2002, The Journal of Biological Chemistry.

Structure-activity studies of cerulenin analogues as protein palmitoylation inhibitors.

D. Lawrence, J. T. Zilfou, C. Smith, 1999, Journal of medicinal chemistry.

A requirement of hydrophobic and basic amino acid residues for substrate recognition by Ca2+/calmodulin-dependent protein kinase Ia.

A. Edelman, J. Lee, D. Lawrence, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Merging of confocal and caging technologies: selective three-color communication with profluorescent reporters.

D. Lawrence, Melanie A. Priestman, Hsien-Ming Lee, 2012, Angewandte Chemie.

Covalent modification with concomitant inactivation of the cAMP-dependent protein kinase by affinity labels containing only L-amino acids.

D. Lawrence, A. Salerno, 1993, The Journal of biological chemistry.

Photoactivation of a Signal Transduction Pathway in Living Cells

D. Lawrence, K. Curley, 1998 .

Cellular effects of small molecule PTP1B inhibitors on insulin signaling.

D. Lawrence, J. Olefsky, J. Andersen, 2003, Biochemistry.

Seeing Is Believing: Peptide-Based Fluorescent Sensors of Protein Tyrosine Kinase Activity

D. Lawrence, Qunzhao Wang, 2007 .

Phosphorylation-driven protein-protein interactions: a protein kinase sensing system.

D. Lawrence, Qunzhao Wang, 2005, Journal of the American Chemical Society.

Phenol kinase activity of the serine/threonine-specific cAMP-dependent protein kinase: steric and electronic effects.

D. Lawrence, J. Niu, T. R. Lee, 1994, Biochemistry.

The chemical modification of enzymatic specificity.

D. Lawrence, S. Rokita, E. Kaiser, 1985, Annual review of biochemistry.

Cell-mediated assembly of phototherapeutics.

D. Lawrence, Christina M Marvin, Weston J Smith, 2014, Angewandte Chemie.

Camphorae: chiral intermediates fob the total synthesis of steroids : Part 2. An enantiospecific approach toward vitamin d metabolites

D. Lawrence, R. V. Stevens, 1985 .

Structure-activity studies of substituted quinoxalinones as multiple-drug-resistance antagonists.

D. Lawrence, C. Smith, Jean E. Copper, 2001, Journal of medicinal chemistry.

Illuminating the chemistry of life: design, synthesis, and applications of "caged" and related photoresponsive compounds.

David S Lawrence, Hsien-Ming Lee, D. Lawrence, 2009, ACS chemical biology.

Self-Assembling Supramolecular Complexes

D. Lawrence, Tao Jiang, Michael. Levett, 1995 .

Chemical mutation of enzyme active sites.

D. Lawrence, E. Kaiser, 1984, Science.

Structures of the 1:1 Complexes of 18-Crown-6 with Hydrazinium Perchlorate, Hydroxylammonium Perchlorate, and Methylammonium Perchlorate

C. Knobler, D. Lawrence, K. Trueblood, 1982 .

Self-Assembling Supramolecular Complexes

David S. Lawrence, D. Lawrence, Tao Jiang, 1995 .

Camphorae: chiral intermediates for the enantiospecific total synthesis of steroids. 1

D. Lawrence, F. Gaeta, R. V. Stevens, 1983 .

Photochemistry and Photophysical Properties of Novel, Unsymmetrically Substituted Metallophthalocyanines

D. Whitten, D. Lawrence, 1996, Photochemistry and photobiology.

Definition of Optimal Substrate Recognition Motifs of Ca2+-Calmodulin-dependent Protein Kinases IV and II Reveals Shared and Distinctive Features*

D S Lawrence, A. Edelman, D. Lawrence, 1998, The Journal of Biological Chemistry.

Molecular encapsulation: cyclodextrin-based analogs of heme-containing proteins

D. Lawrence, D. Sukumaran, T. V. Rao, 1992, Journal of the American Chemical Society.

Self-Assembly of a Threaded Molecular Loop

D. Lawrence, T. V. Rao, 1990 .

Template-driven self-assembly of a porphyrin-containing supramolecular complex

D. Lawrence, J. Maňka, 1990 .

The Synthesis and Characterization of a Pyridine-Linked Cyclodextrin Dimer

D. Lawrence, D. Sukumaran, Tao Jiang, 1994 .

Self-reporting fluorescent substrates of protein tyrosine kinases.

D. Lawrence, S. Cahill, Qunzhao Wang, 2006, Journal of the American Chemical Society.

Synthesis and Molecular Recognition Properties of a .beta.-Cyclodextrin Tetramer

D. Lawrence, Ming Li, Tao Jiang, 1995 .

Self-assembly of a hydrophobic groove

D. Lawrence, J. Maňka, 1989 .

The free base of tetraphenylporphine serves as a host for alkali metal salts

D. Lawrence, J. Maňka, Dennis B Chugh, 1990 .

The cyclic AMP-dependent protein kinase from bovine cardiac muscle is a homoserine kinase.

D. Lawrence, D. Sukumaran, M. Prorok, 1989, The Journal of biological chemistry.

Biosensors of protein kinase action: from in vitro assays to living cells.

D. Lawrence, Chien-an Chen, Xiongwei Yan, 2004, Biochimica et biophysica acta.

Laser Light Therapy in Inflammatory, Musculoskeletal, and Autoimmune Disease

David S. Lawrence, Emilia M. Zywot, D. Lawrence, 2019, Current Allergy and Asthma Reports.

B(12)-mediated, long wavelength photopolymerization of hydrogels.

Jennifer R. Shell, D. Lawrence, Andrew M. Moran, 2015, Journal of the American Chemical Society.

Red Blood Cells for Glucose‐Responsive Insulin Delivery

David S Lawrence, Zhen Gu, Wujin Sun, 2017, Advanced materials.

Noncovalent active site interactions enhance the affinity and control the binding order of reversible inhibitors of the cAMP-dependent protein kinase.

D. Lawrence, M. Prorok, A. Salerno, 1990, The Journal of biological chemistry.

Taking phototherapeutics from concept to clinical launch

Emilia M. Zywot, D. Lawrence, T. Tarrant, 2021, Nature Reviews Chemistry.

Imaging of gene expression in living cells and tissues.

David S Lawrence, Ben Ovryn, Robert H Singer, 2005, Journal of biomedical optics.

The preparation and in vivo applications of caged peptides and proteins.

David S Lawrence, D. Lawrence, 2005, Current opinion in chemical biology.

Real Time Visualization of Protein Kinase Activity in Living Cells* 210

D. Lawrence, A. Bresnick, M. Cammer, 2002, The Journal of Biological Chemistry.

Assessment of Photoreleasable Linkers and Light-Capturing Antennas on a Photoresponsive Cobalamin Scaffold.

D. Lawrence, J. Dempsey, Michael J. Mortelliti, 2022, The Journal of organic chemistry.

Photo-released drugs: a targeted treatment approach for arthritis

Song Ding, Natalia Orlova, David S. Lawrence, 2020, BiOS.

Fluorophore Assisted Photolysis of Thiolato-Cob(III)alamins.

D. Lawrence, M. Forbes, Thomas A. Shell, 2016, Inorganic chemistry.

Vitamin B12: a tunable, long wavelength, light-responsive platform for launching therapeutic agents.

D. Lawrence, Thomas A. Shell, 2015, Accounts of chemical research.

A new trick (hydroxyl radical generation) for an old vitamin (B12).

D. Lawrence, Thomas A. Shell, 2011, Journal of the American Chemical Society.

An Integrated Chemical Cytometry Method: Shining a Light on Akt Activity in Single Cells.

N. Allbritton, D. Lawrence, Qunzhao Wang, 2016, Angewandte Chemie.

Phosphorylation of Adf/Cofilin Abolishes Egf-Induced Actin Nucleation at the Leading Edge and Subsequent Lamellipod Extension

D. Lawrence, J. Condeelis, O. Bernard, 2000, The Journal of cell biology.

Measurement of Protein Kinase B Activity in Single Primary Human Pancreatic Cancer Cells

N. Allbritton, J. Yeh, D. Lawrence, 2014, Analytical chemistry.

Direct observation of frequency modulated transcription in single cells using light activation

D. Larson, D. Lawrence, R. Singer, 2013, eLife.

Crystal Structure of PTP1B Complexed with a Potent and Selective Bidentate Inhibitor*

A. Fedorov, S. Almo, D. Lawrence, 2003, The Journal of Biological Chemistry.

Acquisition of a Specific and Potent PTP1B Inhibitor from a Novel Combinatorial Library and Screening Procedure*

D. Lawrence, Y. Keng, Zhon-Yin Zhang, 2001, The Journal of Biological Chemistry.

Development of a peptidase-resistant substrate for single-cell measurement of protein kinase B activation.

N. Allbritton, D. Lawrence, Angela Proctor, 2012, Analytical Chemistry.

Dasatinib Is Preferentially Active in the Activated B-Cell Subtype of Diffuse Large B-Cell Lymphoma.

Laura E. Herring, D. Lawrence, D. Goldfarb, 2018, Journal of proteome research.

Multiple Regions of MAP Kinase Phosphatase 3 Are Involved in Its Recognition and Activation by ERK2*

D. Lawrence, Bo Zhou, Zhon-Yin Zhang, 2001, The Journal of Biological Chemistry.

Rational Design of a Dephosphorylation-Resistant Reporter Enables Single-Cell Measurement of Tyrosine Kinase Activity.

N. Allbritton, D. Lawrence, Angela Proctor, 2016, ACS chemical biology.

Precision Substrate Targeting of Protein Kinases v-Abl and c-Src (*)

D. Lawrence, W. Miller, J. Till, 1995, The Journal of Biological Chemistry.

New Design Strategies for Ligands That Target Protein Kinase-Mediated Protein-Protein Interactions

D. Lawrence, 2005 .

Functional proteomics: large-scale analysis of protein kinase activity

D. Lawrence, 2001, Genome Biology.

Proteolytic regulation of the mitochondrial cAMP-dependent protein kinase.

Jennifer R. Shell, D. Lawrence, 2012, Biochemistry.

Light-Controlled Release of Therapeutic Proteins from Red Blood Cells

D. Lawrence, Brianna M. Vickerman, X. Tan, 2020, ACS central science.

Cellular pharmacology of cerulenin analogs that inhibit protein palmitoylation.

D. Lawrence, C. Smith, M. L. De Vos, 2001, Biochemical pharmacology.

Precision Substrate Targeting of Protein Kinases

D. Lawrence, J. Corbin, S. Francis, 1996, The Journal of Biological Chemistry.

Potent Low Molecular Weight Substrates for Protein-tyrosine Phosphatase

D. Lawrence, Zhon-Yin Zhang, Li Chen, 1996, The Journal of Biological Chemistry.

Design and Profiling of a Subcellular Targeted Optogenetic cAMP-Dependent Protein Kinase.

Stephen J. Capuzzi, Laura E. Herring, D. Lawrence, 2017, Cell chemical biology.

The Plasma Membrane as a Reservoir, Protective Shield, and Light-Triggered Launch Pad for Peptide Therapeutics.

D. Lawrence, Melanie A. Priestman, Qunzhao Wang, 2016, Angewandte Chemie.

Lipid pools as photolabile "protecting groups": design of light-activatable bioagents.

N. Allbritton, D. Lawrence, Luong T Nguyen, 2013, Angewandte Chemie.

Light-mediated remote control of signaling pathways.

D. Lawrence, Melanie A. Priestman, 2010, Biochimica et biophysica acta.

Cellular Cyborgs: On the Precipice of a Drug Delivery Revolution.

D. Lawrence, S. Ding, C. O'banion, 2018, Cell chemical biology.

Protein kinase C phosphorylates the synthetic peptide Arg-Arg-Lys-Ala-Ser-Gly-Pro-Pro-Val in the presence of phospholipid plus either Ca2+ or a phorbol ester tumor promoter.

D. Lawrence, I. Weinstein, E. Kaiser, 1984, Biochemical and biophysical research communications.

Phototriggered Secretion of Membrane Compartmentalized Bioactive Agents.

D. Lawrence, Christina M Marvin, S. Ding, 2016, Angewandte Chemie.

Presynaptic Role of cGMP-Dependent Protein Kinase during Long-Lasting Potentiation

R. Hawkins, O. Arancio, I. Antonova, 2001, The Journal of Neuroscience.

From consensus sequence to high-affinity ligands: acquisition of signaling protein modulators.

D. Lawrence, Tae Ryong Lee, R. Yeh, 2002, Pharmacology & therapeutics.

ATPase-promoting dead end inhibitors of the cAMP-dependent protein kinase.

D. Lawrence, M. Prorok, A. Salerno, 1993, The Journal of biological chemistry.

From Consensus Sequence Peptide to High Affinity Ligand, a “Library Scan” Strategy*

D. Lawrence, Tae Ryong Lee, R. Yeh, 2001, The Journal of Biological Chemistry.

Steric and stereoelectronic effects on metal ion incorporation into picket fence porphyrins in homogeneous solution: the relationship of molecular conformation to reactivity

D. Whitten, D. Lawrence, D. Barber, 1992 .

Structural basis of plasticity in protein tyrosine phosphatase 1B substrate recognition.

D S Lawrence, S. Almo, D. Lawrence, 2000, Biochemistry.

Acquisition of a potent and selective TC-PTP inhibitor via a stepwise fluorophore-tagged combinatorial synthesis and screening strategy.

D. Lawrence, Zhon-Yin Zhang, A. Gunawan, 2009, Journal of the American Chemical Society.

Measurement of protein tyrosine phosphatase activity in single cells by capillary electrophoresis.

David S Lawrence, Nancy L Allbritton, Christopher E Sims, 2013, Analytical chemistry.

A combinatorial strategy for the acquisition of potent and specific protein tyrosine phosphatase inhibitors.

D. Lawrence, Zhon-Yin Zhang, S. Zhang, 2012, Methods in molecular biology.

Bivalent Inhibitors of Protein Tyrosine Kinases

David S. Lawrence, D. Lawrence, A. Profit, 1999 .

A highly potent and selective PKCalpha inhibitor generated via combinatorial modification of a peptide scaffold.

Sandip K. Nandy, D. Lawrence, J. H. Lee, 2004, Journal of the American Chemical Society.

A mechanistic design principle for protein tyrosine kinase sensors: application to a validated cancer target.

S. Jockusch, N. Turro, D. Lawrence, 2008, Organic letters.

Seeing Is Believing: Peptide‐Based Fluorescent Sensors of Protein Tyrosine Kinase Activity

D. Lawrence, Qunzhao Wang, 2007, Chembiochem : a European journal of chemical biology.

Design and synthesis of a fluorescent reporter of protein kinase activity.

D. Lawrence, Chien-an Chen, R. Yeh, 2002, Journal of the American Chemical Society.

Engineered BRET-Based Biologic Light Sources Enable Spatio-Temporal Control Over Diverse Optogenetic Systems.

J. Cleveland, D. Lawrence, A. Amelio, 2019, ACS synthetic biology.

Optogenetics: A Primer for Chemists

Colin P O'Banion, David S Lawrence, D. Lawrence, 2018, Chembiochem : a European journal of chemical biology.

Multicolor Monitoring of the Proteasome’s Catalytic Signature

D. Lawrence, Melanie A. Priestman, Qunzhao Wang, 2014, ACS chemical biology.

Rate-determining steps for tyrosine phosphorylation by the kinase domain of v-fps.

D. Lawrence, J. Adams, T. R. Lee, 1996, Biochemistry.

PHOTOSENSITIZATION AND TISSUE DISTRIBUTION STUDIES OF THE PICKET FENCE PORPHYRIN, 3,1‐TPRO, A CANDIDATE FOR PHOTODYNAMIC THERAPY

D. Whitten, D. Lawrence, S. Gibson, 1995, Photochemistry and photobiology.

Physicochemical behavior of cytotoxic ether lipids.

D. Lawrence, D. Dick, 1992, Biochemistry.

Molecular Rulers: An Assessment of Distance and Spatial Relationships of Src Tyrosine Kinase SH2 and Active Site Regions*

D. Lawrence, J. Niu, A. Profit, 2001, The Journal of Biological Chemistry.

Cryopreservation of the cyclic 3',5'-adenosine monophosphate-dependent protein kinase from bovine cardiac muscle.

D. Lawrence, M. Prorok, 1989, Journal of biochemical and biophysical methods.

Optogenetic apoptosis: light-triggered cell death.

David S Lawrence, D. Lawrence, Robert M Hughes, 2015, Angewandte Chemie.

Optogenetic perturbation of the biochemical pathways that control cell behavior.

D. Lawrence, Lauren L Haar, R. Hughes, 2019, Methods in enzymology.

SH2-directed ligands of the Lck tyrosine kinase.

D S Lawrence, D. Lawrence, T. R. Lee, 2000, Journal of medicinal chemistry.

Acquisition of high-affinity, SH2-targeted ligands via a spatially focused library.

D. Lawrence, T. R. Lee, 1999, Journal of medicinal chemistry.

Molecular Basis for the Substrate Specificity of a Serine/Threonine-Specific Protein Kinase

D. Lawrence, Young-Guen Kwon, Tae Ryong Lee, 1993 .

Suborganelle sensing of mitochondrial cAMP-dependent protein kinase activity.

Jennifer R. Shell, D. Lawrence, F. Jernigan, 2010, Journal of the American Chemical Society.

From Simple Consensus Peptides to High Affinity Ligands: A Stepwise Diversity Oriented Strategy for the Acquisition of Potent Signaling Inhibitors

D. Lawrence, 2006 .

Assessment of Protein-tyrosine Phosphatase 1B Substrate Specificity Using “Inverse Alanine Scanning”*

D. Lawrence, S. Vetter, Y. Keng, 2000, The Journal of Biological Chemistry.

Identification of phosphocaveolin-1 as a novel protein tyrosine phosphatase 1B substrate.

David S Lawrence, D. Lawrence, F. Sotgia, 2006, Biochemistry.

Probes of the mitochondrial cAMP-dependent protein kinase.

Jennifer R. Shell, D. Lawrence, 2013, Biochimica et biophysica acta.

A molecular constraint that generates a cis peptide bond

David S. Lawrence, D. Lawrence, D. Sukumaran, 1991 .

Acquisition of a "Group A"-selective Src kinase inhibitor via a global targeting strategy.

David S Lawrence, Jung-Mi Hah, D. Lawrence, 2006, Journal of the American Chemical Society.

Chemical probes of signal-transducing proteins.

D. Lawrence, 2003, Accounts of chemical research.

A CAGED PROTEIN KINASE INHIBITOR

David S. Lawrence, D. Lawrence, Judy S. Liu, 1998 .

Design, construction, and intracellular activation of an intramolecularly self-silenced signal transduction inhibitor.

D. Lawrence, S. Cahill, Zhon-Yin Zhang, 2005, Angewandte Chemie.

Potent and highly selective inhibitors of the protein tyrosine phosphatase 1B.

D. Lawrence, Y. Keng, Z. Zhang, 1999, Biochemistry.

Photochemically-activated probes of protein-protein interactions.

Sandip K. Nandy, D. Lawrence, R. S. Agnes, 2007, Organic letters.

VHR and PTP1 protein phosphatases exhibit remarkably different active site specificities toward low molecular weight nonpeptidic substrates

D. Lawrence, Li Chen, Zhong-Yin Zhang, 1996 .

Stereochemistry specifies the regiochemistry of phosphorylation in two cAMP-dependent protein kinase substrates.

D. Lawrence, S. Pluskey, Y. Kwon, 1993, The Journal of biological chemistry.

The cAMP-Dependent Protein Kinase Discriminates between Prochiral Hydroxyl Groups

D. Lawrence, Young-Guen Kwon, S. Pluskey, 1993 .

Enhanced production of functional proteins from defective genes.

D. Lawrence, B. Xi, F. Guan, 2004, Journal of the American Chemical Society.

VHR and PTP1 protein phosphatases exhibit remarkably different active site specificities toward low molecular weight nonpeptidic substrates.

D. Lawrence, Z. Zhang, L. Chen, 1996, Biochemistry.

An affinity-based fluorescence polarization assay for protein tyrosine phosphatases.

D. Lawrence, Sanjai Kumar, Zhon-Yin Zhang, 2007, Methods.

Inhibitors of Protein Kinases and Protein Phosphates Contributors

L. Meijer, D. Fabbro, M. Yacoub, 2005 .

Sugar-Coated Metalated Macrocycles

D. Lawrence, Tao Jiang, 1995 .

Intrasubstrate steric interactions in the active site control the specificity of the cAMP-dependent protein kinase.

D. Lawrence, M. Prorok, 1989, Biochemical and biophysical research communications.

Indoloquinoxaline compounds that selectively antagonize P-glycoprotein.

D. Lawrence, J. T. Zilfou, C. Smith, 2001, Oncology research.