P. Giangrande

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Aptamers as Diagnostic Tools in Cancer

William H. Thiel, William H Thiel, Paloma H Giangrande, 2018, Pharmaceuticals.

Therapeutic applications of DNA and RNA aptamers.

P. Giangrande, K. Thiel, Kristina W. Thiel, 2009, Oligonucleotides.

Myc requires distinct E2F activities to induce S phase and apoptosis.

M E Greenberg, Y Fujiwara, E. Huang, 2001, Molecular cell.

Delivery of chemo-sensitizing siRNAs to HER2+-breast cancer cells using RNA aptamers

Paloma H. Giangrande, William H. Thiel, James O. McNamara, 2012, Nucleic acids research.

Intracellular delivery of RNA-based therapeutics using aptamers.

Paloma H Giangrande, P. Giangrande, K. Thiel, 2010, Therapeutic delivery.

Cell type–specific delivery of siRNAs with aptamer-siRNA chimeras

Yong Wang, Eli Gilboa, J. McNamara, 2006, Nature Biotechnology.

Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors

Anton P. McCaffrey, J. McNamara, A. McCaffrey, 2009, Nature Biotechnology.

Cell-specific aptamers for targeted therapies.

J. McNamara, P. Giangrande, L. Cerchia, 2009, Methods in molecular biology.

Oligonucleotide aptamers: A next-generation technology for the capture and detection of circulating tumor cells.

P. Giangrande, David D. Dickey, 2016, Methods.

Structural basis of prostate-specific membrane antigen recognition by the A9g RNA aptamer

X. Zou, P. Giangrande, Shi-jie Chen, 2020, Nucleic acids research.

Rapid Identification of Cell-Specific, Internalizing RNA Aptamers with Bioinformatics Analyses of a Cell-Based Aptamer Selection

Thomas Bair, Paloma H. Giangrande, William H. Thiel, 2012, PloS one.

Isolation and Optimization of Murine IL-10 Receptor Blocking Oligonucleotide Aptamers Using High-throughput Sequencing.

William H. Thiel, Eli Gilboa, Alexey Berezhnoy, 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

mRNA Therapy Improves Metabolic and Behavioral Abnormalities in a Murine Model of Citrin Deficiency.

C. Lukacs, L. Guey, P. Giangrande, 2019, Molecular therapy : the journal of the American Society of Gene Therapy.

The novel progesterone receptor antagonists RTI 3021-012 and RTI 3021-022 exhibit complex glucocorticoid receptor antagonist activities: implications for the development of dissociated antiprogestins.

M. Breslin, P. Giangrande, G. Pollio, 1999, Endocrinology.

The Novel Progesterone Receptor Antagonists RTI 3021-012 and RTI3021-022 Exhibit Complex Glucocorticoid Receptor Antagonist Activities: Implications for the Development of Dissociated Antiprogestins.

M. Breslin, P. Giangrande, G. Pollio, 1999, Endocrinology.

Targeted inhibition of alphavbeta3 integrin with an RNA aptamer impairs endothelial cell growth and survival.

J. McNamara, B. Sullenger, P. Giangrande, 2005, Biochemical and biophysical research communications.

Structural computational modeling of RNA aptamers.

Xiaojun Xu, P. Giangrande, Shi-jie Chen, 2016, Methods.

LOXL2 Promotes Oncogenic Progression in Alveolar Rhabdomyosarcoma Independently of its Catalytic Activity.

P. Giangrande, D. Herrero-Martín, E. de Álava, 2020, Cancer letters.

83. Cell_Type Specific Delivery of siRNAs with Aptamer_siRNA Chimeras

J. McNamara, B. Sullenger, E. Gilboa, 2006 .

Reduction of chromium(VI) by ascorbate leads to chromium-DNA binding and DNA strand breaks in vitro.

P. Giangrande, K. Courtney, D. Stearns, 1995, Biochemistry.

Smooth Muscle Cell-targeted RNA Aptamer Inhibits Neointimal Formation.

William H. Thiel, William H Thiel, W. Thiel, 2016, Molecular therapy : the journal of the American Society of Gene Therapy.

Design and Preparation of Aptamer-siRNA Chimeras (AsiCs) for Targeted Cancer Therapy.

P. Giangrande, Sven Kruspe, 2017, Methods in molecular biology.

RNA Aptamer-targeted Inhibition of NF-κB Suppresses Non-small Cell Lung Cancer Resistance to Doxorubicin.

M. Dewhirst, B. Sullenger, P. Giangrande, 2008, Molecular therapy : the journal of the American Society of Gene Therapy.

A role for E 2 F 6 in distinguishing G 1 / Sand G 2 / M-specific transcription

J. Nevins, S. Mori, P. Giangrande, 2004 .

essential for cellular proliferation

J. Nevins, M. Greenberg, S. Orkin, 2001 .

RNA Aptamer-Based Functional Ligands of the Neurotrophin Receptor, TrkB

J. McNamara, T. Scheetz, P. Giangrande, 2012, Molecular Pharmacology.

Local intraluminal delivery of a smooth muscle-targeted RNA ligand inhibits neointima growth in a porcine model of peripheral vascular disease

S. Yazdani, P. Giangrande, Beilei Lei, 2022, Molecular therapy. Nucleic acids.

Aptamer-siRNA Chimeras: Discovery, Progress, and Future Prospects

P. Giangrande, Sven Kruspe, 2017, Biomedicines.

Advances in mRNA non-viral delivery approaches.

P. Giangrande, C. Esposito, S. Catuogno, 2021, Advanced drug delivery reviews.

The A and B isoforms of the human progesterone receptor: two functionally different transcription factors encoded by a single gene.

P. Giangrande, D. McDonnell, D P McDonnell, 1999, Recent progress in hormone research.

The E2F1–3 transcription factors are essential for cellular proliferation

J. Nevins, M. Greenberg, S. Orkin, 2001, Nature.

Current progress on aptamer-targeted oligonucleotide therapeutics.

Paloma H. Giangrande, P. Giangrande, Justin P. Dassie, 2013, Therapeutic delivery.

RNA inhibitors of nuclear proteins responsible for multiple organ dysfunction syndrome

S. Murthy, W. Thiel, P. Giangrande, 2019, Nature Communications.

Rapid and Sensitive Detection of Breast Cancer Cells in Patient Blood with Nuclease-Activated Probe Technology

James Schappet, Paloma H. Giangrande, Brian J. Smith, 2017, Molecular therapy. Nucleic acids.

DNA methylation profiling identifies PTRF/Cavin-1 as a novel tumor suppressor in Ewing sarcoma when co-expressed with caveolin-1.

M. Esteller, J. Mora, P. Giangrande, 2017, Cancer letters.

Induction of tumour immunity by targeted inhibition of nonsense-mediated mRNA decay

E. Gilboa, P. Giangrande, F. Pastor, 2010, Nature.

A role for E2F6 in distinguishing G1/S- and G2/M-specific transcription.

Seiichi Mori, Paloma H Giangrande, J. Nevins, 2004, Genes & development.

A role for Myc in facilitating transcription activation by E2F1

J. Nevins, P. Giangrande, G. L. Ehmann, 2008, Oncogene.

Temporal Control of Cell Cycle Gene Expression Mediated by E2F Transcription Factors

J. Nevins, P. Giangrande, Wencheng Zhu, 2005, Cell cycle.

Methods for Evaluating Cell-Specific, Cell-Internalizing RNA Aptamers

Paloma H. Giangrande, Aloysius J. Klingelhutz, P. Giangrande, 2013, Pharmaceuticals.

RNA inhibitors of nuclear proteins responsible for multiple organ dysfunction syndrome

William H. Thiel, William H Thiel, S. Murthy, 2019, Nature Communications.

E2Fs link the control of G1/S and G2/M transcription

J. Nevins, P. Giangrande, Wencheng Zhu, 2004, The EMBO journal.

Combinatorial gene control involving E2F and E Box family members

J. Nevins, P. Giangrande, R. Rempel, 2004, The EMBO journal.

Identification of E-Box Factor TFE3 as a Functional Partner for the E2F3 Transcription Factor

Joseph R. Nevins, Paloma H. Giangrande, J. Nevins, 2003, Molecular and Cellular Biology.

Multivalent 4-1BB binding aptamers costimulate CD8+ T cells and inhibit tumor growth in mice.

J. McNamara, B. Sullenger, E. Gilboa, 2008, The Journal of clinical investigation.

Stick-Based Methods for Aptamer-Mediated siRNA Targeted Delivery.

P. Giangrande, C. Esposito, S. Catuogno, 2021, Methods in molecular biology.

Multifunctional aptamer-miRNA conjugates for targeted cancer therapy.

Silvia Catuogno, Gerolama Condorelli, Paloma H Giangrande, 2014, Molecular therapy : the journal of the American Society of Gene Therapy.

The Opposing Transcriptional Activities of the Two Isoforms of the Human Progesterone Receptor Are Due to Differential Cofactor Binding

Donald P. McDonnell, Paloma H. Giangrande, D. Edwards, 2000, Molecular and Cellular Biology.

Hormone-dependent interaction between the amino- and carboxyl-terminal domains of progesterone receptor in vitro and in vivo.

D. Edwards, P. Giangrande, D. McDonnell, 1999, Molecular endocrinology.

mRNA therapy restores euglycemia and prevents liver tumors in murine model of glycogen storage disease

P. Giangrande, A. Dousis, K. Burke, 2021, Nature Communications.

EphA2 receptor is a key player in the metastatic onset of Ewing sarcoma

J. Mora, P. Giangrande, D. Herrero-Martín, 2018, International Journal of Cancer.

Nucleotide bias observed with a short SELEX RNA aptamer library.

James O McNamara, Thomas Bair, William H. Thiel, 2011, Nucleic acid therapeutics.

Cell-internalization SELEX: method for identifying cell-internalizing RNA aptamers for delivering siRNAs to target cells.

James O McNamara, William H. Thiel, William H Thiel, 2015, Methods in molecular biology.

Targeted Inhibition of Prostate Cancer Metastases with an RNA Aptamer to Prostate-specific Membrane Antigen

W. M. Rockey, D. Meyerholz, P. Giangrande, 2014, Molecular therapy : the journal of the American Society of Gene Therapy.

Aptamer-miRNA-212 Conjugate Sensitizes NSCLC Cells to TRAIL

P. Giangrande, C. Esposito, V. de Franciscis, 2016, Molecular therapy. Nucleic acids.

Synthetic human ABCB4 mRNA therapy rescues severe liver disease phenotype in a BALB/c.Abcb4−/− mouse model of PFIC3

P. An, C. Lukacs, P. Giangrande, 2020, Journal of hepatology.

RNA aptamer-targeted inhibition of NF-kappa B suppresses non-small cell lung cancer resistance to doxorubicin.

M. Dewhirst, B. Sullenger, P. Giangrande, 2008, Molecular therapy : the journal of the American Society of Gene Therapy.

Targeted inhibition of αvβ3 integrin with an RNA aptamer impairs endothelial cell growth and survival

James O McNamara, Paloma H. Giangrande, J. McNamara, 2005 .

Aptamers: cutting edge of cancer therapies.

P. Giangrande, V. de Franciscis, S. Shigdar, 2021, Molecular therapy : the journal of the American Society of Gene Therapy.

Mapping and Characterization of the Functional Domains Responsible for the Differential Activity of the A and B Isoforms of the Human Progesterone Receptor*

P. Giangrande, G. Pollio, D. McDonnell, 1997, The Journal of Biological Chemistry.

Multivalent 4-1 BB binding aptamers costimulate CD 8 + T cells and inhibit tumor growth in mice

J. McNamara, B. Sullenger, E. Gilboa, 2007 .

Rational truncation of an RNA aptamer to prostate-specific membrane antigen using computational structural modeling.

J. McNamara, W. M. Rockey, X. Zou, 2011, Nucleic acid therapeutics.

Generation of a mouse model of Primary Hyperoxaluria Type 1 via CRISPR/Cas9 mediated gene editing

P. Giangrande, P. Martini, A. Frassetto, 2019, Journal of Biochemical and Clinical Genetics.

Chromium(VI) reduction by ascorbate: role of reactive intermediates in DNA damage in vitro.

P. Giangrande, K. Courtney, D. Stearns, 1994, Environmental health perspectives.

Amnio acid substitution at position 298 of human glucose-6 phosphatase-α significantly impacts its stability in mammalian cells

David W. Reid, P. Giangrande, A. Dousis, 2023, Amino Acids.

Synthesis and radiolabeling of chelator-RNA aptamer bioconjugates with copper-64 for targeted molecular imaging.

W. M. Rockey, P. Giangrande, Ling Huang, 2011, Bioorganic & medicinal chemistry.

Functional and Pharmacological Analysis of the A and B Forms of the Human Progesterone Receptor

P. Giangrande, G. Pollio, D. McDonnell, 1998 .

On integrity

P. Giangrande, C. Bricker-Anthony, 2022, Molecular therapy. Nucleic acids.

Inhalation of an RNA aptamer that selectively binds extracellular histones protects from acute lung injury

P. Giangrande, Beilei Lei, A. M. Fager, 2023, Molecular therapy. Nucleic acids.

Distinct roles of E2F proteins in vascular smooth muscle cell proliferation and intimal hyperplasia

J. Nevins, B. Sullenger, P. Giangrande, 2007, Proceedings of the National Academy of Sciences.

Monitoring of breast cancer progression via aptamer-based detection of circulating tumor cells in clinical blood samples

A. V. Krat, N. V. Boyakova, P. Giangrande, 2023, Frontiers in Molecular Biosciences.

67. AptmR: A High Throughput Rational Aptamer Truncation Algorithm

William H Thiel, P. Giangrande, T. Bair, 2015 .

Arresting the colonial destiny of metastatic seeds with DNA aptamers.

P. Giangrande, V. de Franciscis, G. Condorelli, 2015, Molecular therapy : the journal of the American Society of Gene Therapy.

In vitro RNA SELEX for the generation of chemically-optimized therapeutic RNA drugs.

Shi-Jie Chen, Paloma H Giangrande, Sabrina Shore, 2016, Methods.

Analyzing HT-SELEX data with the Galaxy Project tools--A web based bioinformatics platform for biomedical research.

William H. Thiel, William H Thiel, Paloma H Giangrande, 2016, Methods.

Combination of protein and cell internalization SELEX identifies a potential RNA therapeutic and delivery platform to treat EphA2-expressing tumors

William H. Thiel, William H Thiel, P. Giangrande, 2023, Molecular therapy. Nucleic acids.

Synthetic mRNA rescues very long-chain acyl-CoA dehydrogenase deficiency in patient fibroblasts and a murine model.

P. Giangrande, L. Rice, J. Vockley, 2022, Molecular genetics and metabolism.

AFBI assay - Aptamer Fluorescence Binding and Internalization assay for cultured adherent cells.

William H. Thiel, William H Thiel, P. Giangrande, 2016, Methods.

Identification of RNA aptamers that internalize into HPV-16 E6/E7 transformed tonsillar epithelial cells.

William H. Thiel, William H Thiel, W. M. Rockey, 2013, Virology.

Delivery of Cell-Specific Aptamers to the Arterial Wall with an Occlusion Perfusion Catheter

William H. Thiel, William H Thiel, S. Yazdani, 2019, Molecular therapy. Nucleic acids.

Method for Confirming Cytoplasmic Delivery of RNA Aptamers.

P. Giangrande, David D. Dickey, Gregory S. Thomas, 2016, Methods in molecular biology.

The clinical potential of siRNAs for silencing genes critical to disease progression is clear, but a fail-proof method

P. Giangrande, K. Thiel, Kristina W. Thiel, 2010 .

In silico prediction of transcription factors that interact with the E2F family of transcription factors

Qing Zhou, Sheng Zhong, Wing Hung Wong, 2004, ICARCV 2004 8th Control, Automation, Robotics and Vision Conference, 2004..

Impact of stereopure chimeric backbone chemistries on the potency and durability of gene silencing by RNA interference

P. Giangrande, C. Vargeese, Subramanian Marappan, 2023, Nucleic acids research.

Selection of a novel cell-internalizing RNA aptamer specific for CD22 antigen in B cell acute lymphoblastic leukemia

William H. Thiel, P. Giangrande, M. B. Mestre, 2023, Molecular Therapy: Nucleic Acids.

An RNA Aptamer–Based Biomarker Platform Demonstrates High Soluble CD25 Occupancy by IL2 in the Serum of Follicular Lymphoma Patients

William H. Thiel, S. Ansell, P. Giangrande, 2019, Cancer Immunology Research.

Smooth muscle cell-targeted RNA ligand promotes accelerated reendothelialization in a swine peripheral injury model

S. Yazdani, P. Giangrande, Beilei Lei, 2023, Molecular therapy. Nucleic acids.