S. Benjannet

发表

Identification and localization of 7B2 protein in human, porcine, and rat thyroid gland and in human medullary carcinoma.

N. Seidah, M. Marcinkiewicz, S. Benjannet, 1988, Endocrinology.

Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases.

M Chrétien, N. Seidah, R. A. Murphy, 1996, The Biochemical journal.

Mutations in PCSK9 cause autosomal dominant hypercholesterolemia

J. Weissenbach, N. Seidah, C. Junien, 2003, Nature Genetics.

Rosuvastatin, proprotein convertase subtilisin/kexin type 9 concentrations, and LDL cholesterol response: the JUPITER trial.

P. Ridker, D. Chasman, N. Seidah, 2012, Clinical chemistry.

Evidence from a Randomized Trial That Simvastatin, but Not Ezetimibe, Upregulates Circulating PCSK9 Levels

N. Seidah, S. Benjannet, I. Gouni-Berthold, 2013, PloS one.

Atorvastatin increases intestinal expression of NPC1L1 in hyperlipidemic men

N. Seidah, S. Benjannet, H. Davis, 2011, Journal of Lipid Research.

The Proprotein Convertase PC7

N. Seidah, S. Benjannet, J. Hamelin, 2010, The Journal of Biological Chemistry.

Inhibition of Chikungunya Virus Infection in Cultured Human Muscle Cells by Furin Inhibitors

N. Seidah, P. Vidalain, Y. Jacob, 2008, Journal of Biological Chemistry.

Proprotein Covertases Are Responsible for Proteolysis and Inactivation of Endothelial Lipase*

N. Seidah, D. Rader, S. Benjannet, 2005, Journal of Biological Chemistry.

The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis.

N. Seidah, S. Benjannet, M. Chrétien, 2003, The Journal of clinical investigation.

Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization.

N. Seidah, R. A. Murphy, M. Marcinkiewicz, 1999, Proceedings of the National Academy of Sciences of the United States of America.

The proteolytic processing of pro-platelet-derived growth factor-A at RRKR(86) by members of the proprotein convertase family is functionally correlated to platelet-derived growth factor-A-induced functions and tumorigenicity.

N. Seidah, S. Benjannet, M. Chrétien, 2003, Cancer research.

Regulation of the stepwise proteolytic cleavage and secretion of PDGF-B by the proprotein convertases

N. Seidah, S. Benjannet, A. Basak, 2005, Oncogene.

The LIM homeobox protein mLIM3/Lhx3 induces expression of the prolactin gene by a Pit‐1/GHF‐1‐independent pathway in corticotroph AtT20 cells

N. Seidah, S. Girardin, S. Benjannet, 1998, FEBS letters.

The complete sequence of sheep beta-endorphin.

N. Seidah, S. Benjannet, R. Routhier, 1977, Biochemical and biophysical research communications.

The Subtilisin/Kexin Family of Precursor Convertases: Emphasis on PC1, PC2/7B2, POMC and the Novel Enzyme SKI‐1

N. Seidah, M. Marcinkiewicz, S. Benjannet, 1999, Annals of the New York Academy of Sciences.

Post-translational processing of b -secretase (BACE) and its ectodomain shedding: the pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid A b production

N. Seidah, S. Benjannet, M. Chrétien, 2000 .

Proprotein conversion is determined by a multiplicity of factors including convertase processing, substrate specificity, and intracellular environment. Cell type-specific processing of human prorenin by the convertase PC1.

N. Seidah, S. Benjannet, M. Chrétien, 1992, The Journal of biological chemistry.

Differential processing of proenkephalin by prohormone convertases 1(3) and 2 and furin.

N. Seidah, I. Lindberg, M. Breslin, 1993, The Journal of biological chemistry.

Biosynthesis and Cellular Trafficking of the Convertase SKI-1/S1P

N. Seidah, S. Benjannet, L. Wickham, 2002, The Journal of Biological Chemistry.

N-glycosylation controls trafficking, zymogen activation and substrate processing of proprotein convertases PC1/3 and subtilisin kexin isozyme-1.

N. Seidah, S. Benjannet, B. M. Pinto, 2011, Glycobiology.

ZYMOGEN CLEAVAGE AND EFFECTS ON THE LOW DENSITY LIPOPROTEIN (LDL) RECEPTOR AND LDL CHOLESTEROL

A. Prat, N. Seidah, D. Rader, 2004 .

Chloroquine is a potent inhibitor of SARS coronavirus infection and spread

N. Seidah, S. Benjannet, T. Ksiazek, 2005, Virology Journal.

GLYCOPROTEIN MATURATION OF THE E2 SURFACE Inhibitors: IMPAIRMENT OF THE in Cultured Human Muscle Cells by Furin Inhibition of Chikungunya Virus Infection Modification, and Degradation: Protein Synthesis, Post-Translational

N. Seidah, Y. Jacob, P. Desprès, 2013 .

α1-Antitrypsin Portland Inhibits Processing of Precursors Mediated by Proprotein Convertases Primarily within the Constitutive Secretory Pathway*

N. Seidah, A. Laslop, M. Marcinkiewicz, 1997, The Journal of Biological Chemistry.

Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production.

N. Seidah, S. Benjannet, M. Chrétien, 2001, The Journal of biological chemistry.

Proprotein Convertase PC7 Enhances the Activation of the EGF Receptor Pathway through Processing of the EGF Precursor*

N. Seidah, S. Benjannet, C. Lazure, 2011, The Journal of Biological Chemistry.

The Proprotein Convertase SKI-1/S1P

N. Seidah, J. Mayne, S. Benjannet, 2007, Journal of Biological Chemistry.

Biosynthesis and Enzymatic Characterization of Human SKI-1/S1P and the Processing of Its Inhibitory Prosegment*

N. Seidah, S. Benjannet, M. Chrétien, 2000, The Journal of Biological Chemistry.

β‐Amyloid protein converting enzyme 1 and brain‐specific type II membrane protein BRI3: binding partners processed by furin

Louise Wickham, N. Seidah, S. Benjannet, 2005, Journal of neurochemistry.

Comparative biosynthesis, covalent post-translational modifications and efficiency of prosegment cleavage of the prohormone convertases PC1 and PC2: glycosylation, sulphation and identification of the intracellular site of prosegment cleavage of PC1 and PC2.

N. Seidah, S. Benjannet, M. Chrétien, 1993, The Biochemical journal.

Abstract 830: The Proprotein Convertase PCSK9 Induces The Degradation Of LDLR And Its Closest Family Members VLDLR And ApoER2

A. Prat, N. Seidah, S. Benjannet, 2007 .

Role of convertases in the processing of neuropeptides and neurotrophins

N. Seidah, M. Marcinkiewicz, S. Benjannet, 1996 .

From β-lipotropin to β-endorphin and 'pro-opio-melanocortin'

N. Seidah, S. Benjannet, M. Chrétien, 1979 .

The missing fragment of the pro-sequence of human pro-opiomelanocortin: sequence and evidence for C-terminal amidation.

N. Seidah, S. Benjannet, M. Chrétien, 1981, Biochemical and biophysical research communications.

Comparative cellular processing of the human immunodeficiency virus (HIV-1) envelope glycoprotein gp160 by the mammalian subtilisin/kexin-like convertases.

N. Seidah, S. Benjannet, M. Chrétien, 1996, The Biochemical journal.

Comparative functional role of PC7 and furin in the processing of the HIV envelope glycoprotein gp160

N. Seidah, S. Benjannet, E. Decroly, 1997, FEBS letters.

Proprotein convertases [corrected] are responsible for proteolysis and inactivation of endothelial lipase.

N. Seidah, D. Rader, S. Benjannet, 2005, The Journal of biological chemistry.

Chromosomal assignments of the genes for neuroendocrine convertase PC1 (NEC1) to human 5q15-21, neuroendocrine convertase PC2 (NEC2) to human 20p11.1-11.2, and furin (mouse 7[D1-E2] region).

N. Seidah, S. Benjannet, M. Chrétien, 1991, Genomics.

Amyloid Precursor-like Protein 2 and Sortilin Do Not Regulate the PCSK9 Convertase-mediated Low Density Lipoprotein Receptor Degradation but Interact with Each Other*

A. Prat, N. Seidah, Y. Jacob, 2015, The Journal of Biological Chemistry.

Identification and characterization of new gain-of-function mutations in the PCSK9 gene responsible for autosomal dominant hypercholesterolemia.

A. Prat, N. Seidah, J. Michel, 2012, Atherosclerosis.

Evidence for proprotein convertase activity in the endoplasmic reticulum/early Golgi

N. Seidah, S. Benjannet, M. Chrétien, 2005, FEBS letters.

Reinvestigation of the disulfide bridge arrangement in human pro-opiomelanocortin N-terminal segment (hNT 1-76).

N. Seidah, S. Benjannet, M. Chrétien, 2009, International journal of peptide and protein research.

Purification and characterization of the N-terminal fragment of pro-opiomelanocortin from human pituitaries: homology to the bovine sequence.

N. Seidah, S. Benjannet, M. Chrétien, 1980, Biochemical and biophysical research communications.

A novel human pituitary peptide containing the γ-MSH sequence

N. Seidah, S. Benjannet, M. Chrétien, 1980, Nature.

The complete sequence of a novel human pituitary glycopeptide homologous to pig posterior pituitary glycopeptide.

N. Seidah, S. Benjannet, M. Chrétien, 1981, Biochemical and biophysical research communications.

PROCESSING OF PRO-OPIOMELANOCORTIN IN RAT, PORCINE AND HUMAN PITUITARIES

N. Seidah, S. Benjannet, M. Chrétien, 1981 .

Immunohistochemical localization of γ-melanocyte-stimulating hormone in the rat pituitary gland

N. Seidah, S. Benjannet, M. Chrétien, 1981, Regulatory Peptides.

PRO-OPIOMELANOCORTIN: A NEW CONCEPT ISSUED FROM ACTH AND LPH BIOSYNTHETIC STUDIES

N. Seidah, S. Benjannet, M. Chrétien, 1980 .

In vitro biosynthesis and chemical characterization of beta-lipotropin, gamma-lipotropin, and beta-endorphin in rat pars intermedia.

N. Seidah, S. Benjannet, M. Chrétien, 1978, Proceedings of the National Academy of Sciences of the United States of America.

Isolation of peptides with opiate activity from sheep and human pituitaries: relationship to beta-lipotropin.

N. Seidah, S. Benjannet, M. Chrétien, 1976, Biochemical and biophysical research communications.

Biosynthesis of beta-endorphin, beta-lipotropin and the putative ACTH-LPH precursor in the frog pars intermedia.

N. Seidah, S. Benjannet, M. Chrétien, 1978, Life sciences.

Morphine-like activity of sheep β-lipotropin and of its tryptic fragments

N. Seidah, S. Benjannet, M. Chrétien, 1977 .

Reversed-phase high-performance liquid chromatographic purification and characterization of the adrenocorticotropin/lipotropin precursor and its fragments.

N. Seidah, S. Benjannet, M. Chrétien, 1980, Journal of chromatography.

In vitro biosynthesis of beta-endorphin in pituitary glands.

N. Seidah, S. Benjannet, M. Chrétien, 1977, Proceedings of the National Academy of Sciences of the United States of America.

The cDNA structure of the porcine pro‐hormone convertase PC2 and the comparative processing by PC1 and PC2 of the N‐terminal glycopeptide segment of porcine POMC

N. Seidah, S. Benjannet, M. Chrétien, 1992, FEBS letters.

GAWK, a novel human pituitary polypeptide: isolation, immunocytochemical localization and complete amino acid sequence.

N. Seidah, M. Marcinkiewicz, S. Benjannet, 1985, Biochemical and biophysical research communications.

Beta‐endorphin and beta‐lipotropin secretion by an acth‐secreting mouse pituitary tumor

N. Seidah, H. Scherrer, S. Benjannet, 1978, FEBS letters.

Specific cleavage of beta-LPH and ACTH by tonin: release of an opiate-like peptide beta-LPH (61-78).

N. Seidah, S. Benjannet, M. Chrétien, 1979, Biochemical and biophysical research communications.

In vitro biosynthesis of beta-endorphin, gamma-lipoprotein, and beta-lipotropin by the pars intermedia of beef pituitary glands.

N. Seidah, S. Benjannet, M. Chrétien, 1977, Proceedings of the National Academy of Sciences of the United States of America.

Chromogranin B (secretogranin I), a putative precursor of two novel pituitary peptides through processing at paired basic residues

M. Marcinkiewicz, S. Benjannet, J. Falgueyret, 1987, FEBS letters.

The integrity of the RRGDL sequence of the proprotein convertase PC1 is critical for its zymogen and C-terminal processing and for its cellular trafficking.

N. Seidah, S. Benjannet, M. Chrétien, 1997, The Biochemical journal.

Isolation and partial characterization of a biosynthetic N-terminal methionyl peptide of bovine pars intermedia: relationship to ubiquitin.

N. Seidah, H. Scherrer, S. Benjannet, 1978, Biochemical and biophysical research communications.

Invitro biosynthesis off3-endorphin inpituitary glands

N. Seidah, S. Benjannet, P. Crine, 1977 .

Biosynthesis of hormonal and neural peptides.

N. Seidah, S. Benjannet, M. Chrétien, 1984, Transactions of the American Clinical and Climatological Association.

The pituitary polypetide “7B2” is associated with LH/FSH and TSH cells and is localized within secretory vesicles

N. Seidah, M. Marcinkiewicz, S. Benjannet, 1987, Cell and Tissue Research.

In vitro biosynthesis of gamma-lipotropic hormone.

S. Benjannet, M. Chrétien, C. Gilardeau, 1976, Canadian journal of biochemistry.

Rat plasma kallikrein: purification, NH2-terminal sequencing and development of a specific radioimmunoassay.

N. Seidah, S. Benjannet, M. Chrétien, 1989, Biochimica et Biophysica Acta.

Structural and immunological homology of human and porcine pituitary and plasma IRCM-serine protease 1 to plasma kallikrein: marked selectivity for pairs of basic residues suggests a widespread role in pro-hormone and pro-enzyme processing.

N. Seidah, S. Benjannet, M. Chrétien, 1988, Biochimie.

Immunoreactivity of vasopressin and a novel pituitary protein ‘7B2’ in long-evans and brattleboro rat hypothalamus and hypophysis

N. Seidah, M. Marcinkiewicz, S. Benjannet, 1985, Neuroscience Letters.

Maintained PC1 and PC2 expression in the AtT-20 variant cell line 6T3 lacking regulated secretion and POMC: restored POMC expression and regulated secretion after cAMP treatment.

R. Kelly, N. Seidah, M. Marcinkiewicz, 1995, DNA and cell biology.

The Possible Role of Plasma Kallikrein in Pro-Hormone and Pro-Enzyme Processing

N. Seidah, S. Benjannet, M. Chrétien, 1988 .

The messenger RNA for pituitary protein 7B2 is widely expressed in mouse CNS and castration reduces its pituitary level

N. Seidah, S. Benjannet, M. Chrétien, 1991, Neurochemistry International.

Tumorigenicity Platelet-derived Growth Factor-A-induced Functions and Convertase Family Is Functionally Correlated to by Members of the Proprotein 86 Factor-A at RRKR The Proteolytic Processing of Pro-Platelet-derived Growth

N. Seidah, S. Benjannet, M. Chrétien, 2003 .

The Cellular Trafficking of the Secretory Proprotein Convertase PCSK9 and Its Dependence on the LDLR

Annik Prat, A. Prat, N. Seidah, 2007, Traffic.

The Cellular Trafficking of the Secretory Proprotein Convertase PCSK9 and Its Dependence on the LDLR

A. Prat, N. Seidah, A. Attie, 2007 .

Furin Is the Major Processing Enzyme of the Cardiac-specific Growth Factor Bone Morphogenetic Protein 10*

Annik Prat, Daniel Constam, Marie-Claude Asselin, 2011, The Journal of Biological Chemistry.

A new method for measurement of total plasma PCSK 9 : clinical applications

L. Bernier, N. Seidah, S. Benjannet, 2009 .

Correct processing and secretion of a human prostatic secretory protein (PSP94) in Escherichia coli.

N. Seidah, S. Benjannet, M. Chrétien, 1988, Gene.

PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues.

N. Seidah, S. Benjannet, M. Chrétien, 1991, Proceedings of the National Academy of Sciences of the United States of America.

7B2 Is a Specific Intracellular Binding Protein of the Prohormone Convertase PC2

N. Seidah, S. Benjannet, M. Chrétien, 1995, Journal of neurochemistry.

Structure‐function studies on the biosynthesis and bioactivity of the precursor convertase PC2 and the formation of the PC2/7B2 complex

N. Seidah, S. Benjannet, M. Chrétien, 1995, FEBS letters.

Role of Ostm1 Cytosolic Complex with Kinesin 5B in Intracellular Dispersion and Trafficking

N. Seidah, J. Vacher, S. Benjannet, 2015, Molecular and Cellular Biology.

Molecular cloning and sequence of the cDNA for a 94-amino-acid seminal plasma protein secreted by the human prostate.

N. Seidah, S. Benjannet, C. Lazure, 1987, DNA.

Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, Furin, and Kex2: distinct chromosomal localization and messenger RNA distribution in brain and pituitary compared to PC2.

N. Seidah, M. Marcinkiewicz, S. Benjannet, 1991, Molecular endocrinology.

The Proprotein Convertase PCSK9 Induces the Degradation of Low Density Lipoprotein Receptor (LDLR) and Its Closest Family Members VLDLR and ApoER2*

A. Prat, N. Seidah, S. Benjannet, 2008, Journal of Biological Chemistry.

NARC-1/PCSK9 and Its Natural Mutants

A. Prat, N. Seidah, D. Rader, 2004, Journal of Biological Chemistry.

The Proprotein Convertase (PC) PCSK9 Is Inactivated by Furin and/or PC5/6A

N. Seidah, S. Benjannet, Nasha Nassoury, 2006, Journal of Biological Chemistry.

Mammalian neural and endocrine pro-protein and pro-hormone convertases belonging to the subtilisin family of serine proteinases.

M. Marcinkiewicz, S. Benjannet, M. Chrétien, 1991, Enzyme.

The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): Liver regeneration and neuronal differentiation

A. Prat, N. Seidah, S. Benjannet, 2003, Proceedings of the National Academy of Sciences of the United States of America.

The metabolism of -amyloid converting enzyme and -amyloid precursor protein processing

N. Seidah, S. Benjannet, M. Chrétien, 2004 .

Post-translational Processing of β-Secretase (β-Amyloid-converting Enzyme) and Its Ectodomain Shedding

Louise Wickham, N. Seidah, S. Benjannet, 2001, The Journal of Biological Chemistry.

Effects of the Prosegment and pH on the Activity of PCSK9

N. Seidah, R. Parker, S. Benjannet, 2010, The Journal of Biological Chemistry.

Loss- and Gain-of-function PCSK9 Variants

N. Seidah, S. Benjannet, M. Chrétien, 2012, The Journal of Biological Chemistry.

A new method for measurement of total plasma PCSK9: clinical applications

L. Bernier, N. Seidah, S. Benjannet, 2010, Journal of Lipid Research.

CNS distribution of a novel pituitary protein ‘7B2’: localization in secretory and synaptic vesicles

N. Seidah, M. Marcinkiewicz, S. Benjannet, 1986, Brain Research.

Cellular processing of the neurotrophin precursors of NT3 and BDNF by the mammalian proprotein convertases

N. Seidah, S. Benjannet, M. Chrétien, 1996, FEBS letters.

Endoproteolytic processing of integrin pro-alpha subunits involves the redundant function of furin and proprotein convertase (PC) 5A, but not paired basic amino acid converting enzyme (PACE) 4, PC5B or PC7.

N. Seidah, S. Benjannet, M. Chrétien, 2000, The Biochemical journal.

In Vitro Characterization of the Novel Proprotein Convertase PC7*

N. Seidah, S. Benjannet, M. Chrétien, 1997, The Journal of Biological Chemistry.

Immunocytochemical localization of a novel pituitary protein (7B2) within the rat brain and hypophysis.

N. Seidah, M. Marcinkiewicz, S. Benjannet, 1985, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Secretory protein 7B2 is associated with pancreatic hormones within normal islets and some experimentally induced tumors.

N. Seidah, M. Marcinkiewicz, S. Benjannet, 1988, Endocrinology.

Processed forms of neuroendocrine proteins 7B2 and secretogranin II are found in porcine pituitary extracts.

N. Seidah, S. Benjannet, M. Chrétien, 2009, International journal of peptide and protein research.

Two-dimensional immunoblotting analysis and immunocytochemical localization of the secretory polypeptide 7B2 in adrenal medulla

M. Marcinkiewicz, S. Benjannet, J. Falgueyret, 1988, Neuroscience Letters.

Effect of the Mediterranean diet with and without weight loss on surrogate markers of cholesterol homeostasis in men with the metabolic syndrome

N. Seidah, S. Benjannet, A. Lichtenstein, 2011, British Journal of Nutrition.

Residues unique to the pro‐hormone convertase PC2 modulate its autoactivation, binding to 7B2 and enzymatic activity

N. Seidah, S. Benjannet, M. Chrétien, 1998, FEBS letters.

Enzymic characterization of murine and human prohormone convertase-1 (mPC1 and hPC1) expressed in mammalian GH4C1 cells.

N. Seidah, S. Benjannet, M. Chrétien, 1993, The Biochemical journal.

Regional and cellular localization of the neuroendocrine prohormone convertases PC1 and PC2 in the rat central nervous system

N. Seidah, S. Benjannet, P. Dournaud, 2000, The Journal of comparative neurology.

The Prosegments of Furin and PC7 as Potent Inhibitors of Proprotein Convertases

N. Seidah, S. Benjannet, M. Chrétien, 1999, The Journal of Biological Chemistry.

A β‐LPH PRECURSOR MODEL: RECENT DEVELOPMENTS CONCERNING MORPHINE‐LIKE SUBSTANCES

S. Benjannet, M. Chrétien, N. Seidah, 1977, Annals of the New York Academy of Sciences.

Running title : PCSK 9-enhanced LDLR degradation 1 EFFECTS OF THE PROSEGMENT AND PH ON THE ACTIVITY OF PCSK 9 : EVIDENCE FOR ADDITIONAL PROCESSING EVENTS

N. Seidah, R. Parker, S. Benjannet, 2010 .

Amino Terminal Sequence of 7B2: A Novel, Human Pituitary/Brain Polypeptide Present in Gonadotrophs and Released by LHRH

N. Seidah, M. Marcinkiewicz, S. Benjannet, 1987 .

Rosuvastatin, proprotein convertase subtilisin/kexin type 9 concentrations, and LDL cholesterol response: the JUPITER trial.

P. Ridker, D. Chasman, N. Seidah, 2012, Clinical chemistry.

A new method for measurement of total plasma PCSK9: clinical applications

L. Bernier, N. Seidah, S. Benjannet, 2010, Journal of Lipid Research.