D. Mathis

发表

Gene expression microarrays: glimpses of the immunological genome

R. Melamed, C. Benoist, G. Hyatt, 2006, Nature Immunology.

The Immunological Genome Project: networks of gene expression in immune cells

D. Koller, D. Laidlaw, R. Jianu, 2008, Nature Immunology.

Parsing the Interferon Transcriptional Network and Its Disease Associations

Chun Jimmie Ye, N. Hacohen, A. Regev, 2016, Cell.

Transcriptomes of the B and T Lineages Compared by Multiplatform Microarray Profiling

Christophe Benoist, C. Benoist, D. Mathis, 2011, The Journal of Immunology.

Regulatory T cells: recommendations to simplify the nomenclature

A. Rudensky, S. Ziegler, C. Benoist, 2013, Nature Immunology.

Consortium biology in immunology: the perspective from the Immunological Genome Project

C. Benoist, M. Merad, D. Mathis, 2012, Nature Reviews Immunology.

Islet-specific T-cell clones from nonobese diabetic mice express heterogeneous T-cell receptors.

C. Benoist, D. Mathis, J. Katz, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

Mark S. Anderson, C. Benoist, R. Bronson, 2002, Science.

Correcting an immune-response deficiency by creating Eα gene transgenic mice

C. Benoist, D. Mathis, P. Gerlinger, 1985, Nature.

Mice lacking the MHC class II-associated invariant chain

C. Benoist, V. Lotteau, H. Ploegh, 1993, Cell.

Cell Death Mediators in Autoimmune Diabetes—No Shortage of Suspects

C. Benoist, D. Mathis, 1997, Cell.

Immune tolerance : a subject collection from Cold Spring Harbor perspectives in biology

A. Rudensky, D. Mathis, 2013 .

Evolutionary variation of the CCAAT-binding transcription factor NF-Y.

C. Benoist, D. Mathis, R. Mantovani, 1992, Nucleic acids research.

Intersection of population variation and autoimmunity genetics in human T cell activation

Chun Jimmie Ye, N. Hacohen, A. Regev, 2014, Science.

The cellular mechanism of Aire control of T cell tolerance.

Mark S. Anderson, C. Benoist, Emily S. Venanzi, 2005, Immunity.

B cells are required for Aire-deficient mice to develop multi-organ autoinflammation: A therapeutic approach for APECED patients

C. Benoist, D. Mathis, I. Gavanescu, 2008, Proceedings of the National Academy of Sciences.

Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance

C. Benoist, D. Mathis, Siyoung Yang, 2015, Science.

A Plaidoyer for ‘Systems Immunology’

Christophe Benoist, R. Germain, C. Benoist, 2006, Immunological reviews.

Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells.

I. Weissman, C. Benoist, A. Goldrath, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Accurate measurement of pancreatic islet β-cell mass using a second-generation fluorescent exendin-4 analog

Greg M. Thurber, J. Gaglia, R. Weissleder, 2011, Proceedings of the National Academy of Sciences.

Aire controls gene expression in the thymic epithelium with ordered stochasticity

David Zemmour, Christophe Benoist, C. Benoist, 2015, Nature Immunology.

How much TCR does a T cell need?

C Benoist, C. Benoist, R. Obst, 2001, Immunity.

Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in Leukocytes

Daphne Koller, Aviv Regev, Nir Hacohen, 2014, Science.

Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients.

J. Gaglia, R. Weissleder, M. Harisinghani, 2011, The Journal of clinical investigation.

The K/BxN Arthritis Model

Christophe Benoist, C. Benoist, D. Mathis, 2008, Current protocols in immunology.

A Shared Gene-Expression Signature in Innate-Like Lymphocytes.

C. Benoist, T. Yamagata, D. Mathis, 2005 .

Rituximab specifically depletes short-lived autoreactive plasma cells in a mouse model of inflammatory arthritis

C. Benoist, D. Mathis, Haochu Huang, 2010, Proceedings of the National Academy of Sciences.

LAG-3 is not responsible for selecting T helper cells in CD4-deficient mice.

C. Benoist, D. Mathis, A. Dierich, 1996, International immunology.

Noninvasive mapping of pancreatic inflammation in recent-onset type-1 diabetes patients

Ralph Weissleder, Iman Aganj, Christophe Benoist, 2015, Proceedings of the National Academy of Sciences.

A Special Population of Regulatory T Cells Potentiates Muscle Repair

C. Benoist, D. Mathis, A. Wagers, 2013, Cell.

Protective major histocompatibility complex allele prevents type 1 diabetes by shaping the intestinal microbiota early in ontogeny

C. Benoist, D. Mathis, K. Bittinger, 2017, Proceedings of the National Academy of Sciences.

Modifier loci condition autoimmunity provoked by Aire deficiency

Mark S. Anderson, C. Benoist, D. Mathis, 2005, The Journal of experimental medicine.

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

Christophe Benoist, Laura Herrero, A. Goldfine, 2009, Nature Medicine.

Tissue regulatory T cells: regulatory chameleons

D. Mathis, A. Muñoz-Rojas, 2021, Nature Reviews Immunology.

Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices in vivo

K. Garcia, C. Benoist, D. Mathis, 2020, eLife.

Methods of Isolation and Analysis of TREG Immune Infiltrates from Injured and Dystrophic Skeletal Muscle.

D. Mathis, A. Wagers, M. Cerletti, 2019, Methods in molecular biology.

Appearance and disappearance of the mRNA signature characteristic of Treg cells in visceral adipose tissue: Age, diet, and PPARγ effects

B. Spiegelman, C. Benoist, D. Mathis, 2014, Proceedings of the National Academy of Sciences.

Immunological goings-on in visceral adipose tissue.

D. Mathis, 2013, Cell metabolism.

The immune system's involvement in obesity-driven type 2 diabetes.

C. Benoist, D. Mathis, C. Shu, 2012, Seminars in immunology.

A multiply redundant genetic switch ‘ locks in ’ the transcriptional signature of regulatory T cells

J. Collins, T. Lu, C. Benoist, 2012 .

Tissular T(regs): a unique population of adipose-tissue-resident Foxp3+CD4+ T cells that impacts organismal metabolism.

C. Benoist, D. Mathis, D. Kolodin, 2011, Seminars in immunology.

Single-cell analysis of FOXP3 deficiencies in humans and mice unmasks intrinsic and extrinsic CD4+ T cell perturbations

F. Rieux-Laucat, C. Benoist, T. Chatila, 2020, Nature Immunology.

Developmental and cellular age direct conversion of CD4+ T cells into RORγ+ or Helios+ colon Treg cells

C. Benoist, D. Mathis, Alvin Pratama, 2019, The Journal of experimental medicine.

Regulatory T cells control NK cells in an insulitic lesion by depriving them of IL-2

K. Garcia, C. Benoist, D. Mathis, 2013, The Journal of experimental medicine.

Interleukin-4 can be a key positive regulator of inflammatory arthritis.

C. Benoist, R. Locksley, L. Nguyen, 2005, Arthritis and rheumatism.

Immunology at Asilomar: from molecules to mice

D. Mathis, Christopher B Wilson, C. Uittenbogaart, 2003, Nature Immunology.

Mice lacking all conventional MHC class II genes.

C. Benoist, L. Fugger, D. Mathis, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Lack of requirement of osteopontin for inflammation, bone erosion, and cartilage damage in the K/BxN model of autoantibody-mediated arthritis.

C. Benoist, J. Jacobs, D. Mathis, 2004, Arthritis and rheumatism.

Another view of the selective model of thymocyte selection

C. Benoist, D. Mathis, C. Waltzinger, 1993, Cell.

The thymic compartment responsible for positive selection of CD4+ T cells.

C. Benoist, D. Mathis, C. Waltzinger, 1992, International immunology.

How defects in central tolerance impinge on a deficiency in regulatory T cells.

C. Benoist, D. Mathis, Zhibin Chen, 2005, Proceedings of the National Academy of Sciences of the United States of America.

The molecular program induced in T cells undergoing homeostatic proliferation.

Richard Park, Christophe Benoist, C. Benoist, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Transgenic mice: 'new wave' immunogenetics.

C. Benoist, D. Mathis, M. Lemeur, 1986, Immunology today.

γδT cells and adipocyte IL-17RC control fat innervation and thermogenesis

Alexander S. Banks, B. Spiegelman, B. Lowell, 2019, Nature.

Different modes of pathogenesis in T‐cell‐dependent autoimmunity: clues from two TCR transgenic systems

C. Benoist, L. Poirot, D. Mathis, 1999, Immunological reviews.

Arthritogenic Monoclonal Antibodies from K/BxN Mice

C. Benoist, D. Mathis, M. V. Van Regenmortel, 2002, The Journal of experimental medicine.

Neonatal tolerance revisited: a perinatal window for Aire control of autoimmunity

C. Benoist, D. Mathis, M. Martinic, 2009, The Journal of experimental medicine.

Modeling CTLA4-linked autoimmunity with RNA interference in mice

C. Benoist, D. Mathis, Zhibin Chen, 2006, Proceedings of the National Academy of Sciences.

Response to Letter from Mucida et al.

P. Chambon, Y. Belkaid, C. Benoist, 2009 .

Tissue Tregs.

C. Benoist, D. Mathis, Marisella Panduro, 2016, Annual review of immunology.

The same genomic region conditions clonal deletion and clonal deviation to the CD8αα and regulatory T cell lineages in NOD versus C57BL/6 mice

C. Benoist, T. Yamagata, D. Mathis, 2007, Proceedings of the National Academy of Sciences.

Environmental modulation of the autonomy of cytotoxic T lymphocytes

C. Benoist, D. Mathis, Susan Chan, 1993, European journal of immunology.

Sperm cells as vectors for transferring DNA into mouse eggs: a breakthrough for immunologists?

C. Benoist, D. Mathis, 1989, Immunology today (Amsterdam. Regular ed.).

Noninvasive imaging of pancreatic inflammation and its reversal in type 1 diabetes.

R. Weissleder, C. Benoist, D. Mathis, 2005, The Journal of clinical investigation.

Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis

C. Benoist, N. Geva-Zatorsky, XiMei Sun, 2019, Nature.

Critical Roles for Interleukin 1 and Tumor Necrosis Factor α in Antibody-induced Arthritis

C. Benoist, D. Mathis, K. Ohmura, 2002, The Journal of experimental medicine.

Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire

C. Benoist, D. Mathis, D. Gray, 2007, The Journal of experimental medicine.

OX40 Ligand Self-Reactivity but Promotion of Diabetes by Paradoxical Dampening of Anti-Islet

C. Benoist, L. Poirot, D. Mathis, 2003 .

Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3.

L. Notarangelo, C. Klein, S. Pai, 2015, Blood.

IMMUNOBIOLOGY Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP 3

L. Notarangelo, C. Klein, S. Pai, 2015 .

Enhanced thymic selection of FoxP3+ regulatory T cells in the NOD mouse model of autoimmune diabetes

Ansuman T. Satpathy, C. Benoist, D. Mathis, 2007, Proceedings of the National Academy of Sciences.

Positive selection of T cells: fastidious or promiscuous?

C. Benoist, D. Mathis, 1997, Current opinion in immunology.

The influence of invariant chain on the positive selection of single T cell receptor specificities

C. Benoist, D. Mathis, S. Viville, 1995, European journal of immunology.

The virtue of complexity

C. Benoist, D. Mathis, 1993, Current Biology.

Delineation of antigen contact residues on an MHC class II molecule.

C. Benoist, J. Peccoud, D. Mathis, 1990, The EMBO journal.

Treg cells: guardians for life

C. Benoist, D. Mathis, Jonathan A Hill, 2007, Nature Immunology.

Functional in vivo MHC class II loading by endogenously synthesized glycoprotein during viral infection.

R. Zinkernagel, C. Benoist, A. Oxenius, 1997, Journal of immunology.

The phenotype of H‐2M‐deficient mice is dependent on the MHC class II molecules expressed

C. Benoist, H. Ploegh, D. Mathis, 1998, European journal of immunology.

Independent Modes of Natural Killing Distinguished in Mice Lacking Lag3

C. Benoist, D. Mathis, A. Dierich, 1996, Science.

Checkpoints in the progression of autoimmune disease: lessons from diabetes models.

C. Benoist, D. Mathis, J. Katz, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Differential splicing across immune system lineages

Henry H. Paik, J. Collins, J. Costello, 2013, Proceedings of the National Academy of Sciences.

Thymic epithelial cells co-opt lineage-defining transcription factors to eliminate autoreactive T cells

C. Benoist, T. Kaisho, D. Mathis, 2022, Cell.

Evaluation of the functional equivalence of major histocompatibility complex class II A and E complexes

C. Benoist, D. Mathis, M. Bogue, 1992, The Journal of experimental medicine.

b-Cell death during progression to diabetes

C. Benoist, D. Mathis, L. Vence, 2001 .

Inbred Mouse Strains Expression in Primary Immunocytes across Variation and Genetic Control of Gene

D. Koller, A. Regev, V. Jojic, 2014 .

Good riddance: Thymocyte clonal deletion prevents autoimmunity.

C. Benoist, Emily S. Venanzi, D. Mathis, 2004, Current opinion in immunology.

DB130204 188..202

J. Gaglia, D. Mathis, E. Dirice, 2013 .

Major Histocompatibility Complex Class II Molecules Can Protect from Diabetes by Positively Selecting T Cells with Additional Specificities

C. Benoist, D. Mathis, J. Katz, 1998, The Journal of experimental medicine.

Inflammatory arthritis can be reined in by CpG-induced DC–NK cell cross talk

J. Carulli, R. Weissleder, C. Benoist, 2007, The Journal of experimental medicine.

Fas deficiency prevents type 1 diabetes by inducing hyporesponsiveness in islet beta-cell-reactive T-cells.

C. Benoist, D. Mathis, L. Vence, 2004, Diabetes.

1527 Physiological (cid:2) Cell Death Triggers Priming of Self-reactive T Cells by Dendritic Cells in a Type-1 Diabetes

C. Benoist, L. Poirot, D. Mathis, 2003 .

Promiscuity Promotes Tolerance

C. Benoist, D. Mathis, 2016, The Journal of Immunology.

Evidence for a single-niche model of positive selection.

C. Benoist, D. Mathis, M. Merkenschlager, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Where FoxP3-dependent regulatory T cells impinge on the development of inflammatory arthritis.

Christophe Benoist, C. Benoist, L. Nguyen, 2007, Arthritis and rheumatism.

A multiple redundant genetic switch locks in the transcriptional signature of T regulatory cells

James J. Collins, Philippe Kastner, Ting Lu, 2012, Nature Immunology.

Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells.

Christophe Benoist, C. Benoist, D. Mathis, 2010, Immunity.

Rapid, high efficiency isolation of pancreatic ß-cells

R. Weissleder, Y. Iwamoto, C. Benoist, 2015, Scientific Reports.

Endoscopic photoconversion reveals unexpectedly broad leukocyte trafficking to and from the gut

R. Weissleder, C. Benoist, D. Mathis, 2014, Proceedings of the National Academy of Sciences.

A gut feeling about arthritis The gut microbiota of patients recently diagnosed with rheumatoid arthritis is enriched in microbes belonging to the Prevotella genus.

C. Huttenhower, D. Mathis, A. Sczesnak, 2013 .

A gut feeling about arthritis

D. Mathis, 2013, eLife.

A shared gene‐expression signature in innate‐like lymphocytes

Tetsuya Yamagata, Christophe Benoist, C. Benoist, 2006, Immunological reviews.

β-Cell death during progression to diabetes

Christophe Benoist, C. Benoist, D. Mathis, 2001, Nature.

Structural Basis for the Transition from Initiation to Elongation Transcription in T 7 RNA Polymerase

Christophe Benoist, C. Benoist, R. Bronson, 2022 .

Positive selection of the T cell repertoire: Where and when does it occur?

Christophe Benoist, C. Benoist, D. Mathis, 1989, Cell.

Brief De 6 nltive Report Evaluation of the Functional Equivalence of Major Histocompatibility Complex Class H A and E Complexes

C. Benoist, D. Mathis, M. Bogue, 2003 .

A Challenge to the Instructive Model of Positive Selection

C. Benoist, D. Mathis, Susan Chan, 1993, Immunological reviews.

Why is clonal deletion of neonatal thymocytes defective?

C. Benoist, D. Mathis, K. Signorelli, 1992, European journal of immunology.

MHC-linked protection from diabetes dissociated from clonal deletion of T cells.

C. Benoist, D. Mathis, J. Böhme, 1990, Science.

Conserved major histocompatibility complex class II boxes--X and Y--are transcriptional control elements and specifically bind nuclear proteins.

C. Benoist, D. Mathis, M. L. Meur, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Arthritis critically dependent on innate immune system players.

Ralph Weissleder, Umar Mahmood, Christophe Benoist, 2002, Immunity.

The neuropeptide neuromedin U promotes autoantibody-mediated arthritis

R. Weissleder, C. Benoist, D. Mathis, 2012, Arthritis Research & Therapy.

Circulating C3 is necessary and sufficient for induction of autoantibody-mediated arthritis in a mouse model

C. Benoist, J. Jacobs, D. Mathis, 2007, Arthritis and rheumatism.

The K/BxN mouse model of inflammatory arthritis: theory and practice.

C. Benoist, L. Nguyen, D. Mathis, 2007, Methods in molecular medicine.

Green TR Cells

C. Benoist, D. Mathis, M. Feuerer, 2005 .

B-cell control region at the 5' end of a major histocompatibility complex class II gene: sequences and factors

C. Benoist, D. Mathis, P. Gerlinger, 1988, Molecular and cellular biology.

B-Cell Control Region atthe5'Endofa MajorHistocompatibili ty ComplexClass II Gene:Sequences andFactors

C. Benoist, D. Mathis, M. Lemeur, 1988 .

Transgenic Mice: New Systems for Studying the Function of MHC Class II Molecules

C. Benoist, D. Mathis, M. L. Meur, 1987 .

Generation of the αβ T-cell repertoire

C. Benoist, D. Mathis, 1992 .

Visualization of CD4/CD8 T Cell Commitment

C. Benoist, D. Mathis, A. Dierich, 1998, The Journal of experimental medicine.

Transgenic mice carrying the rearranged T cell receptor of a diabetogenic T cell clone

C. Benoist, D. Mathis, J. Katz, 1994 .

Major histocompatibility complex class I molecules are required for the development of insulitis in non‐obese diabetic mice

C. Benoist, D. Mathis, J. Katz, 1993, European journal of immunology.

Regulatory T‐cell differentiation: Committed to control: a precocious choice?

C. Benoist, D. Mathis, S. Haxhinasto, 2007, Immunology and cell biology.

Different molecular complexes that mediate transcriptional induction and repression by FoxP3

C. Benoist, D. Mathis, Ho-Keun Kwon, 2017, Nature Immunology.

Unstable FoxP3+ T regulatory cells in NZW mice

C. Benoist, D. Mathis, Ho-Keun Kwon, 2016, Proceedings of the National Academy of Sciences.

The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors

C. Benoist, D. Mathis, M. Feuerer, 2008, Proceedings of the National Academy of Sciences.

Back to central tolerance.

C. Benoist, D. Mathis, 2004, Immunity.

Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity

C. Benoist, H. Ploegh, D. Mathis, 2007, Proceedings of the National Academy of Sciences.

The arthritogenic T cell receptor and its ligand in a model of spontaneous arthritis.

V. Kouskoff, C. Benoist, D. Mathis, 1999, Arthritis and rheumatism.

Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Regulates the Unfolding of Autoimmune Diabetes

C. Benoist, J. Allison, D. Mathis, 1998, The Journal of experimental medicine.

Anti-CD3 therapy permits regulatory T cells to surmount T cell receptor–specified peripheral niche constraints

C. Benoist, D. Mathis, M. Feuerer, 2010, The Journal of experimental medicine.

Interleukin-4 Deficiency Does Not Exacerbate Disease in NOD Mice

C. Benoist, D. Mathis, J. Katz, 1998, Diabetes.

The role of CD8+ T cells in the initiation of insulin‐dependent diabetes mellitus

C. Benoist, D. Mathis, Antonio Gonzalez, 1996, European journal of immunology.

Several mechanisms can account for defective E alpha gene expression in different mouse haplotypes.

V. E. Williams, H. Mcdevitt, C. Benoist, 1983, Proceedings of the National Academy of Sciences of the United States of America.

CD4+ T cell responses in mice lacking MHC class II molecules specifically on B cells

C. Benoist, A. Oxenius, D. Mathis, 1998, European journal of immunology.

Genetic inversion in mast cell-deficient (Wsh) mice interrupts corin and manifests as hematopoietic and cardiac aberrancy.

C. Benoist, D. Mathis, D. Gray, 2008, The American journal of pathology.

PAHSAs attenuate immune responses and promote β cell survival in autoimmune diabetic mice.

A. Saghatelian, D. Mathis, D. Siegel, 2019, The Journal of clinical investigation.

Type 1 Diabetes in NOD Mice Unaffected by Mast Cell Deficiency

D. Mathis, A. Liston, A. ortiz-lopez, 2014, Diabetes.

Graft rejection by T cells not restricted by conventional major histocompatibility complex molecules

C. Benoist, D. Mathis, A. Dierich, 1993, European journal of immunology.

Fine-tuning of MHC class II gene expression in defined microenvironments.

C. Benoist, D. Mathis, S. Viville, 1989, Trends in genetics : TIG.

CD4/CD8 lineage commitment: matching fate with competence

C. Benoist, D. Mathis, Susan Chan, 1998, Immunological reviews.

Positive Selection of T Cells Induced by Viral Delivery of Neopeptides to the Thymus

C. Benoist, D. Mathis, N. Nakano, 1997, Science.

Mice lacking the transcription factor CIITA--a second look.

C. Benoist, C. Chang, D. Mathis, 1998, International immunology.

Anatomy of a new B-cell-specific enhancer

C. Benoist, D. Mathis, W. Koch, 1989, Molecular and cellular biology.

New B-lymphocyte-specific enhancer-binding protein

C. Benoist, D. Mathis, A. Dorn, 1989, Molecular and cellular biology.

An enhancer factor defect in a mutant Burkitt lymphoma cell line

C. Benoist, D. Mathis, S. Candéias, 1988, The Journal of experimental medicine.

A revival of the B cell paradigm for rheumatoid arthritis pathogenesis?

C. Benoist, D. Mathis, 2000, Arthritis research.

Fluorescent exendin-4 derivatives for pancreatic β-cell analysis.

R. Weissleder, C. Benoist, D. Mathis, 2014, Bioconjugate chemistry.

The NOD mouse.

D. Mathis, J. Bach, 1997, Research in immunology.

Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells.

C. Benoist, J. Allison, D. Mathis, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Cellular and molecular changes accompanying the progression from insulitis to diabetes

C. Benoist, D. Mathis, I. André-Schmutz, 1999, European journal of immunology.

Determinant capture as a possible mechanism of protection afforded by major histocompatibility complex class II molecules in autoimmune disease

D. Mathis, E. Sercarz, L. Adorini, 1993, The Journal of experimental medicine.

Lack of Foxp3 function and expression in the thymic epithelium

A. Rudensky, C. Benoist, N. Manley, 2007, The Journal of experimental medicine.

Cathepsin L is essential for onset of autoimmune diabetes in NOD mice.

R. Maehr, C. Benoist, H. Ploegh, 2005, The Journal of clinical investigation.

Selection of a Broad Repertoire of CD 4 1 T Cells in H-2 Ma 0 / 0 Mice

C. Benoist, A. Oxenius, D. Mathis, 1997 .

Fatal in mice reconstituted with human stem cells

L. Notarangelo, S. Snapper, W. Marasco, 2015 .

An Intestinal Organ Culture System Uncovers a Role for the Nervous System in Microbe-Immune Crosstalk

Yan Zhou, David A. Weitz, Christophe Benoist, 2017, Cell.

Self-reactivity in thymic double-positive cells commits cells to a CD8 alpha alpha lineage with characteristics of innate immune cells.

C. Benoist, T. Yamagata, D. Mathis, 2004, Nature immunology.

T lymphocytes need IL-7 but not IL-4 or IL-6 to survive in vivo.

C. Benoist, D. Mathis, L. Vivien, 2001, International immunology.

Singular role for T-BET+CXCR3+ regulatory T cells in protection from autoimmune diabetes

C. Benoist, D. Mathis, T. G. Tan, 2016, Proceedings of the National Academy of Sciences.

Gut Immune Maturation Depends on Colonization with a Host-Specific Microbiota

David A. Relman, Sünje J. Pamp, Christophe Benoist, 2012, Cell.

The immunosuppressant 15-deoxyspergualin [correction of 1,5- deoxyspergualin] reveals commonality between preT and preB cell differentiation

C. Benoist, D. Mathis, B. Wang, 1996, The Journal of experimental medicine.

The murine Ia alpha chains, E alpha and A alpha, show a surprising degree of sequence homology.

V. E. Williams, H. Mcdevitt, C. Benoist, 1983, Proceedings of the National Academy of Sciences of the United States of America.

A single amino acid substitution in the Ak molecule fortuitously provokes an alloresponse

C. Benoist, D. Mathis, P. Dellabona, 1991, European journal of immunology.

I-Ak polymorphisms define a functionally dominant region for the presentation of hen egg lysozyme peptides.

J. Freed, J. Buerstedde, C. Benoist, 1989, Journal of immunology.

I-A alpha polymorphic residues that determine alloreactive T cell recognition

C. Benoist, J. Peccoud, D. Mathis, 1989, The Journal of experimental medicine.

Functionality of major histocompatibility complex class II molecules in mice doubly deficient for invariant chain and H-2M complexes.

C. Benoist, H. Ploegh, D. Mathis, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Diversity of endogenous epitopes bound to MHC class II molecules limited by invariant chain.

C. Benoist, D. Mathis, S. Viville, 1994, Science.

Epitopes of I-A k Involved in Antigen Presentation to T-Cell Hybridomas

J. Freed, D. Mathis, D. McKean, 1987 .

Sustained antigen presentation can promote an immunogenic T cell response, like dendritic cell activation

R. Melamed, C. Benoist, A. Kamphorst, 2007, Proceedings of the National Academy of Sciences.

Aire’s plant homeodomain(PHD)-2 is critical for induction of immunological tolerance

C. Benoist, D. Mathis, Siyoung Yang, 2013, Proceedings of the National Academy of Sciences.

Immunological Yin-Yang

D. Mathis, J. Lafaille, 2002 .

Thymic mimetic cells: tolerogenic masqueraders.

D. Mathis, Daniel A. Michelson, Daniel A Michelson, 2022, Trends in immunology.

Deficient type I protein kinase A isozyme activity in systemic lupus erythematosus T lymphocytes: II. Abnormal isozyme kinetics.

D. Mathis, G. Kammer, I. Khan, 1996, Journal of immunology.

A new mouse model of rheumatoid arthritis: organ-specific disease provoked by systemic autoimmunity.

V. Kouskoff, C. Benoist, D. Mathis, 1997, Ryumachi. [Rheumatism].

Autoimmunity: The pathogen connection

C. Benoist, D. Mathis, 1998, Nature.

Antiviral immune responses of mice lacking MHC class II or its associated invariant chain.

R. Zinkernagel, C. Benoist, M. Battegay, 1996, Cellular immunology.

Yes, it does

C. Benoist, D. Mathis, 2007, Nature Reviews Immunology.

Biosynthesis of major histocompatibility complex molecules and generation of T cells in Ii TAP1 double-mutant mice.

C. Benoist, H. Ploegh, D. Mathis, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Global relevance of Aire binding to hypomethylated lysine-4 of histone-3

R. Kingston, C. Benoist, D. Mathis, 2010, Proceedings of the National Academy of Sciences.

An influence of CD5 on the selection of CD4‐lineage T cells

A. Tarakhovsky, C. Benoist, D. Mathis, 1999, European journal of immunology.

Demystification of the alloresponse

C. Benoist, D. Mathis, 1991, Current Biology.

B-cell Signaling: Protein Kinase Cδ Puts the Brakes on

G. King, D. Mathis, 2002, Current Biology.

Convergent and divergent effects of costimulatory molecules in conventional and regulatory CD4+ T cells

C. Benoist, D. Mathis, E. Wakamatsu, 2012, Proceedings of the National Academy of Sciences.

Tregs in visceral adipose tissue up-regulate circadian-clock expression to promote fitness and enforce a diurnal rhythm of lipolysis

C. Benoist, M. Lazar, D. Mathis, 2022, Science Immunology.

The transcriptional landscape of αβ T cell differentiation

G. Nolan, C. Benoist, D. Mathis, 2013, Nature Immunology.

Sequestration of gut pathobionts in intraluminal casts, a mechanism to avoid dysregulated T cell activation by pathobionts

C. Benoist, D. Mathis, A. ortiz-lopez, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Properties of reticulum cell sarcomas in SJL/J mice VI. Characterization of lymphoid cells that proliferate in response to RCS cells.

D. Mathis, G. Thorbecke, N. Ponzio, 1976 .

MHC Control of the Naive TCR a-Chain Repertoire’

C. Benoist, D. Mathis, M. Merkenschlager, 2001 .

MHC control of the naive TCR alpha-chain repertoire.

C. Benoist, D. Mathis, M. Merkenschlager, 1994, Journal of immunology.

Initiation of Autoimmune Diabetes by Developmentally Regulated Presentation of Islet Cell Antigens in the Pancreatic Lymph Nodes

C. Benoist, D. Mathis, C. Waltzinger, 1999, The Journal of experimental medicine.

A vector driving the expression of foreign cDNAs in the MHC class II-positive cells of transgenic mice.

V. Kouskoff, C. Benoist, D. Mathis, 1993, Journal of immunological methods.

One subunit of the transcription factor NF-Y maps close to the major histocompatibility complex in murine and human chromosomes.

J. Nadeau, C. Benoist, D. Mathis, 1991, Genomics.

The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells

C. Benoist, D. Mathis, S. Haxhinasto, 2008, The Journal of experimental medicine.

Following a diabetogenic T cell from genesis through pathogenesis

C. Benoist, D. Mathis, J. Katz, 1993, Cell.

The influence of positive selection on RAG expression in thymocytes

J. Vonesch, V. Kouskoff, C. Benoist, 1995, European journal of immunology.

Toxic MHC class II beta chains.

C. Benoist, L. Fugger, D. Mathis, 1999, Immunity.

Functional sites on Ia molecules: a molecular dissection of A alpha immunogenicity.

C. Benoist, D. Mathis, D. Landais, 1986, Cell.

E alpha u and E beta u chain association: where lies the anomaly?

H. Mcdevitt, C. Benoist, D. Mathis, 1986, Journal of immunology.

Properties of a CCAAT box-binding protein.

C. Benoist, D. Mathis, R. Hooft van Huijsduijnen, 1987, Nucleic acids research.

Structure and Expression of the Murine Ia α Chains

V. E. Williams, H. Mcdevitt, C. Benoist, 1983 .

Restricted assembly of MHC class II molecules in transgenic mice.

C. Benoist, D. Mathis, C. Waltzinger, 1989, Journal of immunology.

IL-33, Imprimatur of Adipocyte Thermogenesis

D. Mathis, 2016, Cell.

Organismal immunometabolism: advances in both directions

D. Mathis, 2019, Nature Reviews Immunology.

Restoration of the Unfolded Protein Response in Pancreatic β Cells Protects Mice Against Type 1 Diabetes

D. Mathis, D. Eizirik, G. Hotamisligil, 2013, Science Translational Medicine.

Nuclear receptor Nr4a1 modulates both regulatory T-cell (Treg) differentiation and clonal deletion

C. Benoist, D. Mathis, M. Fassett, 2012, Proceedings of the National Academy of Sciences.

Antigen- and cytokine-driven accumulation of regulatory T cells in visceral adipose tissue of lean mice.

Christine M. Miller, R. Germain, C. Benoist, 2015, Cell metabolism.

Imaging inflammation of the pancreatic islets in type 1 diabetes.

R. Weissleder, C. Benoist, D. Mathis, 2004, Proceedings of the National Academy of Sciences of the United States of America.

T helper cell subsets in insulin-dependent diabetes.

C Benoist, C. Benoist, D. Mathis, 1995, Science.

Autoimmunity provoked by infection: how good is the case for T cell epitope mimicry?

C. Benoist, D. Mathis, 2001, Nature Immunology.

Role of coreceptors in positive selection and lineage commitment.

C. Benoist, D. Mathis, C. Waltzinger, 1994, The EMBO journal.

The enhancer in an MHC class II gene, in vitro and in mouso.

C. Benoist, D. Mathis, C. Waltzinger, 1988, Biochimie.

Anatomy of a new B-cell-specific enhancer.

C. Benoist, D. Mathis, W. Koch, 1989, Molecular and cellular biology.

The murine E alpha immune response gene.

V. E. Williams, H. Mcdevitt, C. Benoist, 1983, Cell.

Several mechanisms can account for defective E gene expression in different mouse haplotypes (Ia antigens/major histocompatibility complex/immune response genes/recombinant DNA/Southern blotting)

V. E. Williams, C. Benoist, D. Mathis, 2016 .

Inbred and wild mice carry identical deletions in their E alpha MHC genes.

C. Benoist, D. Mathis, M. Steinmetz, 1985, The EMBO journal.

Correcting an immune-response deficiency by creating E alpha gene transgenic mice.

C. Benoist, D. Mathis, P. Gerlinger, 1985, Nature.

A dynamic atlas of immunocyte migration from the gut

C. Benoist, D. Mathis, Bola S Hanna, 2022, bioRxiv.

Intrathymic delivery of MHC genes using recombinant adenoviruses.

C. Benoist, D. Mathis, R. Rooke, 2000, Methods in molecular biology.

Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity

Or Gozani, Christophe Benoist, Jakub Abramson, 2008, Proceedings of the National Academy of Sciences.

Intron-exon organization of the NF-Y genes. Tissue-specific splicing modifies an activation domain.

C. Benoist, D. Mathis, R. Mantovani, 1992, The Journal of biological chemistry.

Mast cells jump start K/BxN serum transfer arthritis via IL-1

C. Benoist, D. Mathis, Y. Iwakura, 2007, Arthritis Research & Therapy.

The Immunosuppressant 1 , 5-deoxyspergualin Reveals

C. Benoist, D. Mathis, Bo Wang, 2003 .

The Immunosuppressan t lin Reveals Commonality between PreT and PreB Cell Differentiation

C. Benoist, D. Mathis, Bo Wang, 1996 .

T-Cell Co-Receptors: The end of a frustrating search

C. Benoist, D. Mathis, 1994, Current Biology.

A broad analysis of IL1 polymorphism and rheumatoid arthritis.

Vincent L. Butty, P. Gregersen, R. Plenge, 2008, Arthritis and rheumatism.

The role of antibodies in mouse models of rheumatoid arthritis, and relevance to human disease.

C. Benoist, D. Mathis, P. Monach, 2004, Advances in immunology.

Mining the Human Gut Microbiota for Immunomodulatory Organisms

C. Benoist, N. Geva-Zatorsky, D. Mathis, 2017, Cell.

Physiological β Cell Death Triggers Priming of Self-reactive T Cells by Dendritic Cells in a Type-1 Diabetes Model

C. Benoist, L. Poirot, D. Mathis, 2003, The Journal of experimental medicine.

How antibodies to a ubiquitous cytoplasmic enzyme may provoke joint-specific autoimmune disease

C. Benoist, D. Mathis, I. Matsumoto, 2002, Nature Immunology.

Individual intestinal symbionts induce a distinct population of RORγ+ regulatory T cells

Liza Konnikova, David Zemmour, Christophe Benoist, 2015, Science.

A decade of AIRE

C. Benoist, D. Mathis, 2007, Nature Reviews Immunology.

Immunological contributions to adipose tissue homeostasis.

D. Mathis, J. DiSpirito, Joanna R DiSpirito, 2015, Seminars in immunology.

Cre-mediated cell ablation contests mast cell contribution in models of antibody- and T cell-mediated autoimmunity.

C. Benoist, D. Mathis, H. Fehling, 2011, Immunity.

Mice lacking MHC class II molecules

D. Gray, J. Kaufman, C. Benoist, 1991, Cell.

CD1-restricted CD4+ T cells in major histocompatibility complex class II-deficient mice

C. Benoist, D. Mathis, M. Kronenberg, 1995, The Journal of experimental medicine.

The Type 1 Diabetes PhysioLab® Platform: a validated physiologically based mathematical model of pathogenesis in the non‐obese diabetic mouse

K Gadkar, S Ramanujan, K. Gadkar, 2010, Clinical and experimental immunology.

Treg cells limit IFN-γ production to control macrophage accrual and phenotype during skeletal muscle regeneration

C. Benoist, D. Mathis, Marisella Panduro, 2018, Proceedings of the National Academy of Sciences.

Regulation of major histocompatibility complex class-II genes: X, Y and other letters of the alphabet.

C. Benoist, D. Mathis, 1990, Annual review of immunology.

TCR Transgenic Mice Reveal Stepwise, Multi-site Acquisition of the Distinctive Fat-Treg Phenotype

C. Benoist, D. Mathis, D. Zemmour, 2018, Cell.

Poor Repair of Skeletal Muscle in Aging Mice Reflects a Defect in Local, Interleukin-33-Dependent Accumulation of Regulatory T Cells.

C. Benoist, D. Mathis, A. Wagers, 2016, Immunity.

The murine Eα immune response gene

V. E. Williams, H. Mcdevitt, C. Benoist, 1983, Cell.

A microRNA expression and regulatory element activity atlas of the mouse immune system

Jason D. Buenrostro, A. Regev, E. Kenigsberg, 2021, Nature Immunology.

PPARγ is a major driver of the accumulation and phenotype of adipose-tissue Treg cells

C. Benoist, D. Mathis, M. Feuerer, 2012, Nature.

Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells

R. Young, C. Benoist, D. Mathis, 2011, Proceedings of the National Academy of Sciences.

Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice

C. Benoist, D. Mathis, Esen Sefik, 2011, Proceedings of the National Academy of Sciences.

Gut CD4+ T cell phenotypes are a continuum molded by microbes, not by TH archetypes.

S. Mostafavi, C. Benoist, D. Mathis, 2020, Nature immunology.

Identifying species of symbiont bacteria from the human gut that, alone, can induce intestinal Th17 cells in mice

C. Benoist, N. Geva-Zatorsky, D. Mathis, 2016, Proceedings of the National Academy of Sciences.

Stability of the Regulatory T Cell Lineage in Vivo

Christophe Benoist, A. Rudensky, C. Benoist, 2010, Science.

Molecular diversification of regulatory T cells in nonlymphoid tissues

Allon M. Klein, C. Benoist, R. Zilionis, 2018, Science Immunology.

Genome-wide and species-wide dissection of the genetics of arthritis severity in heterogeneous stock mice.

J. Flint, W. Valdar, C. Benoist, 2011, Arthritis and rheumatism.

Flicr, a long noncoding RNA, modulates Foxp3 expression and autoimmunity

C. Benoist, D. Mathis, D. Zemmour, 2017, Proceedings of the National Academy of Sciences.

The V 17 + T Cell Repertoire : Skewed Jfl Usage after Thymic Selection ; Dissimilar CDR 3 s in CD 4 + Versus CD 8 + Cells

D. Mathis, C. Waltzinger, tophe Benoist, 2003 .

Paradoxical Dampening of Anti-Islet Self-Reactivity but Promotion of Diabetes by OX40 Ligand1

C. Benoist, L. Poirot, D. Mathis, 2003, The Journal of Immunology.

Inhibition of thymocyte positive selection by natural MHC: peptide ligands

C Benoist, V. Kouskoff, C. Benoist, 1999, European journal of immunology.

Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity.

Kenji Yoshida, Christophe Benoist, Laurent Poirot, 2003, The Journal of clinical investigation.

Thymic negative selection is functional in NOD mice

C. Benoist, D. Mathis, M. Feuerer, 2012, The Journal of experimental medicine.

A comprehensive review of interventions in the NOD mouse and implications for translation.

Saroja Ramanujan, Richard Kahn, R. Kahn, 2005, Immunity.

Transcriptional impact of Aire varies with cell type

C. Benoist, D. Mathis, M. Guerau-de-Arellano, 2008, Proceedings of the National Academy of Sciences.

Population dynamics of islet-infiltrating cells in autoimmune diabetes

Greg M. Thurber, R. Weissleder, C. Benoist, 2015, Proceedings of the National Academy of Sciences.

Dominant negative analogs of NF-YA.

C. Benoist, D. Mathis, R. Mantovani, 1994, The Journal of biological chemistry.

How punctual ablation of regulatory T cells unleashes an autoimmune lesion within the pancreatic islets.

C. Benoist, D. Mathis, M. Feuerer, 2009, Immunity.

The transcriptional regulator Aire binds to and activates super-enhancers

C. Benoist, D. Mathis, H. Yoshida, 2017, Nature Immunology.

Aire's Partners in the Molecular Control of Immunological Tolerance

C. Benoist, D. Mathis, M. Giraud, 2010, Cell.

Transgenic mice with I-A on islet cells are normoglycemic but immunologically intolerant.

C. Benoist, D. Mathis, M. Lemeur, 1989, Science.

IL-17A–producing γδT cells promote muscle regeneration in a microbiota-dependent manner

C. Benoist, D. Mathis, I. Prinz, 2022, The Journal of experimental medicine.

PPARγ marks splenic precursors of multiple nonlymphoid-tissue Treg compartments

C. Benoist, D. Mathis, A. Muñoz-Rojas, 2021, Proceedings of the National Academy of Sciences.

Neuronal, stromal, and T-regulatory cell crosstalk in murine skeletal muscle

Omar K. Yaghi, C. Benoist, D. Mathis, 2020, Proceedings of the National Academy of Sciences.

T cell receptor specificity drives accumulation of a reparative population of regulatory T cells within acutely injured skeletal muscle

C. Benoist, D. Mathis, Wilson Kuswanto, 2019, Proceedings of the National Academy of Sciences.

Amino acid residues on the I-Ak alpha-chain required for the binding and stability of two antigenic peptides.

E. Unanue, C. Nelson, N. Viner, 1996, Journal of immunology.

Interindividual variation in human T regulatory cells

B. Stranger, T. Raj, C. Benoist, 2014, Proceedings of the National Academy of Sciences.

Genetic Influences on the End-Stage Effector Phase of Arthritis

D. Gauguier, M. Lathrop, C. Benoist, 2001, The Journal of experimental medicine.

ImmGen microarray gene expression data: Data Generation and Quality Control pipeline

Christophe Benoist, C. Benoist, D. Mathis, 2012 .

Adaptation of TCR Repertoires to Self-Peptides in Regulatory and Nonregulatory CD4+ T Cells1

C. Benoist, R. Obst, D. Mathis, 2007, The Journal of Immunology.

FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT

J. Stroud, S. Ziegler, C. Benoist, 2006, Cell.

The transcriptional landscape of αβ T cell differentiation

Charles C. Kim, G. Nolan, D. Koller, 2013, Nature Immunology.

Transgenes and knock-outs in autoimmunity.

C. Benoist, D. Mathis, 1993, Current opinion in immunology.

Commercially Available Outbred Mice for Genome-Wide Association Studies

Laurent Farinelli, David J. Adams, Jonathan Flint, 2010, PLoS genetics.

Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and β cells

R. Weissleder, C. Benoist, R. Prinjha, 2014, eLife.

Interferon-gamma impacts at multiple points during the progression of autoimmune diabetes.

C. Benoist, D. Mathis, J. Katz, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Signatures of strong population differentiation shape extended haplotypes across the human CD28, CTLA4, and ICOS costimulatory genes

Vincent L. Butty, Pardis C Sabeti, C. Benoist, 2007, Proceedings of the National Academy of Sciences.

Interleukin-6 produced by enteric neurons regulates the number and phenotype of microbe-responsive regulatory T cells in the gut.

Omar K. Yaghi, S. Itzkovitz, C. Benoist, 2021, Immunity.

Self-reactivity in thymic double-positive cells commits cells to a CD8αα lineage with characteristics of innate immune cells

C. Benoist, T. Yamagata, D. Mathis, 2004, Nature Immunology.

ImmGen at 15

Jason D. Buenrostro, E. Amir, A. Regev, 2020, Nature Immunology.

Cytokine Requirements for Acute and Basal Homeostatic Proliferation of Naive and Memory CD8+ T Cells

C. Benoist, M. Bevan, A. Goldrath, 2002, The Journal of experimental medicine.

Role of the forkhead transcription family member, FKHR, in thymocyte differentiation

C. Benoist, D. Mathis, H. Leenders, 2000, European journal of immunology.

The shaping of the T cell repertoire.

C. Benoist, D. Mathis, C. Waltzinger, 2001, Immunity.

Amino Acids Specifying MHC Class Preference in TCR Vα2 Regions

C. Benoist, D. Mathis, C. Waltzinger, 1999, The Journal of Immunology.

Cassette vectors directing expression of T cell receptor genes in transgenic mice.

V. Kouskoff, C. Benoist, D. Mathis, 1995, Journal of immunological methods.

A broad screen for targets of immune complexes decorating arthritic joints highlights deposition of nucleosomes in rheumatoid arthritis

C. Benoist, H. Ploegh, W. Robinson, 2009, Proceedings of the National Academy of Sciences.

Brd4 bridges the transcriptional regulators, Aire and P-TEFb, to promote elongation of peripheral-tissue antigen transcripts in thymic stromal cells

Mark S. Anderson, A. Tarakhovsky, C. Benoist, 2015, Proceedings of the National Academy of Sciences.

T cell receptor specificity and diabetes in nonobese diabetic mice.

C. Benoist, D. Mathis, 1993, Science.

Defective central tolerance induction in NOD mice: genomics and genetics.

C. Benoist, S. Zucchelli, T. Yamagata, 2005, Immunity.

Organ-Specific Disease Provoked by Systemic Autoimmunity

V. Kouskoff, C. Benoist, D. Mathis, 1996, Cell.

Neutrophils in a mouse model of autoantibody-mediated arthritis: critical producers of Fc receptor gamma, the receptor for C5a, and lymphocyte function-associated antigen 1.

C. Benoist, D. Mathis, P. Nigrovic, 2010, Arthritis and rheumatism.

Mast cells contribute to initiation of autoantibody-mediated arthritis via IL-1

C. Benoist, D. Mathis, Y. Iwakura, 2007, Proceedings of the National Academy of Sciences.

Mast Cells: A Cellular Link Between Autoantibodies and Inflammatory Arthritis

C. Benoist, D. Mathis, D. Friend, 2002, Science.

Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme.

C. Benoist, D. Mathis, I. Matsumoto, 1999, Science.

From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins.

K. Rajewsky, C. Benoist, D. Mathis, 1999, Immunity.

CD4 CD25 T Regulatory Cells Dependent on ICOS Promote Regulation of Effector Cells in the Prediabetic Lesion

G. Freeman, C. Benoist, A. Herman, 2004 .

An Immunologic Mode of Multigenerational Transmission Governs a Gut Treg Setpoint

A. Kostic, C. Benoist, D. Mathis, 2020, Cell.

FoxP3 associates with enhancer-promoter loops to regulate Treg-specific gene expression

C. Benoist, D. Mathis, Ricardo N. Ramirez, 2021, bioRxiv.

The gut microbiota promotes distal tissue regeneration via RORγ+ regulatory T cell emissaries.

C. Benoist, D. Mathis, Gang Wang, 2023, Immunity.

The influence of the microbiota on type‐1 diabetes: on the threshold of a leap forward in our understanding

C. Benoist, D. Mathis, 2012, Immunological reviews.

Microbiota and autoimmune disease: the hosted self.

C. Benoist, D. Mathis, 2011, Cell host & microbe.

Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses.

C. Benoist, D. Hafler, V. Kuchroo, 2014, Immunity.

A multiplicity of CCAAT box-binding proteins

C. Benoist, D. Mathis, A. Dorn, 1987, Cell.

Aire regulates chromatin looping by evicting CTCF from domain boundaries and favoring accumulation of cohesin on superenhancers

C. Benoist, R. Levine, D. Mathis, 2021, Proceedings of the National Academy of Sciences.

Ectopic expression of peripheral-tissue antigens in the thymic epithelium: Probabilistic, monoallelic, misinitiated

C. Benoist, D. Mathis, Whitney Besse, 2008, Proceedings of the National Academy of Sciences.

Profound Treg perturbations correlate with COVID-19 severity

B. Walker, C. Benoist, Xu G. Yu, 2020, bioRxiv.

Visceral adipose tissue Tregs and the cells that nurture them

D. Mathis, Chaoran Li, R. Spallanzani, 2020, Immunological reviews.

Abrogation of antibody-induced arthritis in mice by a self-activating viridin prodrug and association with impaired neutrophil and endothelial cell function.

M. Yaffe, R. Weissleder, L. Josephson, 2009, Arthritis and rheumatism.

Danger-free autoimmune disease in Aire-deficient mice

C. Benoist, D. Mathis, D. Gray, 2007, Proceedings of the National Academy of Sciences.

Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand

Mark M. Davis, C. Benoist, D. Mathis, 1989, Cell.

Quantitative phosphoproteomic analysis of T cell receptor signaling in diabetes prone and resistant mice.

Forest M White, Christophe Benoist, C. Benoist, 2010, Journal of proteome research.

The immune system of mice lacking conventional MHC class II molecules.

C. Benoist, D. Mathis, M. Merkenschlager, 1994, Advances in immunology.

Compartmentalization of MHC class II gene expression in transgenic mice

C. Benoist, P. Marrack, Y. Ron, 1988, Cell.

Antigen persistence is required throughout the expansion phase of a CD4+ T cell response

Christophe Benoist, C. Benoist, R. Obst, 2005, The Journal of experimental medicine.

A cassette vector for high-level reporter expression driven by a hybrid invariant chain promoter in transgenic mice.

C. Benoist, D. Mathis, H. V. van Santen, 2000, Journal of immunological methods.

Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch

Alexander S. Banks, B. Spiegelman, Yingying Zhang, 2014, Cell.

Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature.

Christophe Benoist, R. Melamed, C. Benoist, 2007, Immunity.

Endocrine self and gut non-self intersect in the pancreatic lymph nodes.

C. Benoist, D. Mathis, S. Turley, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Profound Treg perturbations correlate with COVID-19 severity

B. Walker, C. Benoist, Xu G. Yu, 2021, Proceedings of the National Academy of Sciences.

Mice lacking TdT: mature animals with an immature lymphocyte repertoire.

C. Benoist, D. Mathis, A. Dierich, 1993, Science.

Deficiency of CXCR2, but not other chemokine receptors, attenuates autoantibody-mediated arthritis in a murine model.

C. Benoist, J. Jacobs, D. Mathis, 2010, Arthritis and rheumatism.

Chromosomal clustering of genes controlled by the aire transcription factor.

C. Benoist, Emily S. Venanzi, D. Mathis, 2005, Proceedings of the National Academy of Sciences of the United States of America.

AIRE and APECED: molecular insights into an autoimmune disease

C. Benoist, D. Mathis, J. Villaseñor, 2005, Immunological reviews.

Lymphotoxin Pathway and Aire Influences on Thymic Medullary Epithelial Cells Are Unconnected1

C. Benoist, Emily S. Venanzi, D. Mathis, 2007, The Journal of Immunology.

Identification and validation of a tumor-infiltrating Treg transcriptional signature conserved across species and tumor types

R. Weissleder, C. Benoist, D. Mathis, 2018, Proceedings of the National Academy of Sciences.

Differential Response of Regulatory and Conventional CD4+ Lymphocytes to CD3 Engagement: Clues to a Possible Mechanism of Anti-CD3 Action?

C. Benoist, D. Mathis, J. Nishio, 2013, The Journal of Immunology.

Genomic definition of multiple ex vivo regulatory T cell subphenotypes

C. Benoist, D. Mathis, M. Feuerer, 2010, Proceedings of the National Academy of Sciences.

Foxp3+ regulatory T cells: differentiation, specification, subphenotypes

C. Benoist, D. Mathis, M. Feuerer, 2009, Nature Immunology.

Where CD4+CD25+ T reg cells impinge on autoimmune diabetes

C. Benoist, Michael Matos, A. Herman, 2005, The Journal of experimental medicine.

Properties of reticulum cell sarcomas in SJL/J mice. V. Nature of reticulum cell sarcoma surface antigen which induces proliferation of normal SJL/J T cells

D. Mathis, N. Ponzio, R. Cone, 1977, Immunogenetics.

The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments

Jason D. Buenrostro, A. Regev, E. Kenigsberg, 2021, Nature Communications.

ImmVar project: Insights and design considerations for future studies of "healthy" immune variation.

N. Hacohen, A. Regev, B. Stranger, 2015, Seminars in immunology.

Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR

Allon M Klein, Allon M. Klein, David Zemmour, 2018, Nature Immunology.

TCR-based lineage tracing: no evidence for conversion of conventional into regulatory T cells in response to a natural self-antigen in pancreatic islets

C. Benoist, D. Mathis, J. Wong, 2007, The Journal of experimental medicine.

Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells.

P. Chambon, Y. Belkaid, C. Benoist, 2008, Immunity.

Mast cells in autoimmune disease

C. Benoist, D. Mathis, 2002, Nature.

Soluble Factors Secreted by T Cells Promote β-Cell Proliferation

J. Gaglia, D. Mathis, E. Dirice, 2013, Diabetes.

An RNAi screen for Aire cofactors reveals a role for Hnrnpl in polymerase release and Aire-activated ectopic transcription

N. Hacohen, D. Root, C. Benoist, 2014, Proceedings of the National Academy of Sciences.

The variable immunological self: Genetic variation and nongenetic noise in Aire-regulated transcription

R. Melamed, C. Benoist, Emily S. Venanzi, 2008, Proceedings of the National Academy of Sciences.

Dual functions of Aire CARD multimerization in the transcriptional regulation of T cell tolerance

Wesley P. Wong, D. Yang, D. Mathis, 2020, Nature Communications.

Structure of a domain-swapped FOXP3 dimer on DNA and its function in regulatory T cells.

J. Stroud, C. Benoist, D. Mathis, 2011, Immunity.

Somatic hypermutation occurs in B cells of terminal deoxynucleotidyl transferase‐, CD23‐, interleukin‐4‐, IgD‐ and CD30‐deficient mouse mutants

K. Rajewsky, T. Mak, C. Benoist, 1996, European journal of immunology.

Mice Lacking H2-M Complexes, Enigmatic Elements of the MHC Class II Peptide-Loading Pathway

C. Benoist, H. Ploegh, D. Mathis, 1996, Cell.

Induction of tolerance in arthritogenic B cells with receptors of differing affinity for self-antigen.

J. Kearney, C. Benoist, D. Mathis, 2006, Proceedings of the National Academy of Sciences of the United States of America.

The Regulation of Ia Gene Transcription

C. Benoist, D. Mathis, M. Lemeur, 1986 .

Treg cells, life history, and diversity.

C. Benoist, D. Mathis, 2012, Cold Spring Harbor perspectives in biology.

Natural killer cells distinguish innocuous and destructive forms of pancreatic islet autoimmunity.

Christophe Benoist, Laurent Poirot, C. Benoist, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Spotting a killer's target in autoimmune diabetes

C. Benoist, D. Mathis, 1999, Nature Medicine.

Regulation of N-region diversity in antigen receptors through thymocyte differentiation and thymus ontogeny.

C. Benoist, D. Mathis, M. Bogue, 1992, Proceedings of the National Academy of Sciences of the United States of America.

FoxP3 scanning mutagenesis reveals functional variegation and mild mutations with atypical autoimmune phenotypes

C. Benoist, D. Mathis, Ho-Keun Kwon, 2017, Proceedings of the National Academy of Sciences.

In favor of the selective model of positive selection.

C. Benoist, D. Mathis, S. Chan, 1994, Seminars in immunology.

Results The Pancreatic Lesion Includes CD 4 T Cell Subpopulations with Both Effector and Regulatory Phenotypes

G. Freeman, C. Benoist, A. Herman, 2004 .

Regulatory T cells in nonlymphoid tissues

C. Benoist, D. Mathis, Dalia Burzyn, 2013, Nature Immunology.

Disease The Immunogenetic Architecture of Autoimmune An Goris and Adrian Liston Self-Control ? Natural Killer Cell Tolerance : Control by Self or

Baptiste N. Jaeger, C. Benoist, R. Locksley, 2012 .

Fat T reg cells : a liaison between the immune and metabolic systems

Christophe Benoist, Laura Herrero, A. Goldfine, 2011 .

Progression to islet destruction in a cyclophosphamide-induced transgenic model: a microarray overview.

C. Benoist, R. Park, Michael Matos, 2004, Diabetes.

Regions of allelic hypervariability in the murine Aα immune response gene

V. E. Williams, H. Mcdevitt, C. Benoist, 1983, Cell.

Superantigens interact with MHC class II molecules outside of the antigen groove

C. Benoist, P. Marrack, J. Peccoud, 1990, Cell.

A Broad Analysis of IL 1 Polymorphism and Rheumatoid Arthritis

Vincent L. Butty, P. Gregersen, R. Plenge, 2008 .

beta-Cell death during progression to diabetes.

C Benoist, C. Benoist, D. Mathis, 2001, Nature.

Engagement: Clues to a Possible Mechanism Lymphocytes to CD3 + Conventional CD4 Differential Response of Regulatory and

C. Benoist, D. Mathis, Li Li, 2013 .

Low prevalence of antibodies to glucose-6-phosphate isomerase in patients with rheumatoid arthritis and a spectrum of other chronic autoimmune disorders.

P. Schur, C. Benoist, M. Weinblatt, 2003, Arthritis and rheumatism.

Selection of a broad repertoire of CD4+ T cells in H-2Ma0/0 mice.

C. Benoist, A. Oxenius, D. Mathis, 1997, Immunity.

Functional sites on la molecules: A molecular dissection of Aα immunogenicity

C. Benoist, D. Mathis, D. Landais, 1986, Cell.

T-cell compartments of prediabetic NOD mice.

C. Benoist, Emily S. Venanzi, D. Mathis, 2003, Diabetes.

Variation in IL-1beta gene expression is a major determinant of genetic differences in arthritis aggressivity in mice.

M. Lathrop, C. Benoist, D. Mathis, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Co‐evolution from yeast to mouse: cDNA cloning of the two NF‐Y (CP‐1/CBF) subunits.

C. Benoist, D. Mathis, R. Hooft van Huijsduijnen, 1990, The EMBO journal.

Variation and Genetic Control of Gene Expression in Primary Immunocytes across Inbred Mouse Strains

D. Koller, S. Mostafavi, C. Benoist, 2014, The Journal of Immunology.

Molecular definition of the identity and activation of natural killer cells

Charles C. Kim, A. Regev, V. Jojic, 2012, Nature Immunology.

Monoclonal antibodies to NF‐Y define its function in MHC class II and albumin gene transcription.

C. Benoist, D. Mathis, R. Mantovani, 1992, The EMBO journal.

Interferon-α-producing plasmacytoid dendritic cells drive the loss of adipose tissue regulatory T cells during obesity.

C. Benoist, D. Mathis, Ricardo N. Ramirez, 2021, Cell metabolism.

Immunometabolism: an emerging frontier

D. Mathis, S. Shoelson, Diane Mathis, 2011, Nature Reviews Immunology.

Correction: A Genetic and Functional Relationship between T Cells and Cellular Proliferation in the Adult Hippocampus

R. Mott, J. Flint, P. Klenerman, 2011, PLoS Biology.

A Genetic and Functional Relationship between T Cells and Cellular Proliferation in the Adult Hippocampus

R. Mott, J. Flint, P. Klenerman, 2010, PLoS biology.

Sex-specific adipose tissue imprinting of regulatory T cells

David Chisanga, W. Shi, Yang Liao, 2020, Nature.

Number of T Reg Cells That Differentiate Does Not Increase upon Encounter of Agonist Ligand on Thymic Epithelial Cells

C. Benoist, D. Mathis, H. V. van Santen, 2004, The Journal of experimental medicine.

An N-terminal mutation of the Foxp3 transcription factor alleviates arthritis but exacerbates diabetes.

A. Rudensky, C. Benoist, D. Mathis, 2012, Immunity.

Functional consequences of overexpressed Ia antigens in Aαk/Aβk transgenic mice.

C. Benoist, D. Mathis, C. Waltzinger, 1990 .

Antigen‐presenting Function of the TL Antigen and Mouse CD1 Molecules

P. A. Peterson, C. Benoist, W. Huse, 1995, Immunological reviews.

The V beta 17+ T cell repertoire: skewed J beta usage after thymic selection; dissimilar CDR3s in CD4+ versus CD8+ cells

C. Benoist, D. Mathis, C. Waltzinger, 1991, The Journal of experimental medicine.

Damage control, rather than unresponsiveness, effected by protective DX5+ T cells in autoimmune diabetes

C. Benoist, D. Mathis, C. Carnaud, 2001, Nature Immunology.

A cluster of coregulated genes determines TGF-β–induced regulatory T-cell (Treg) dysfunction in NOD mice

C. Benoist, D. Mathis, A. D’Alise, 2011, Proceedings of the National Academy of Sciences.

Regions of allelic hypervariability in the murine A alpha immune response gene.

V. E. Williams, H. Mcdevitt, C. Benoist, 1983, Cell.

NF-X, a transcription factor implicated in MHC class II gene regulation.

V. Kouskoff, C. Benoist, C. Griscelli, 1991, Journal of immunology.

The E alpha promoter: a linker-scanning analysis.

C. Benoist, D. Mathis, R. Mantovani, 1991, Journal of immunology.

Particularities of the vasculature can promote the organ specificity of autoimmune attack

R. Weissleder, C. Benoist, D. Mathis, 2006, Nature Immunology.

The level of N‐region diversity in T cell receptors is not pre‐ordained in the stem cell

C. Benoist, D. Mathis, M. Bogue, 1993, European journal of immunology.

Network pharmacology of JAK inhibitors

S. Mostafavi, C. Benoist, D. Mathis, 2016, Proceedings of the National Academy of Sciences.

A nomenclature solution to mouse MHC confusion.

P. Cresswell, J. Rodgers, D. Mathis, 1999, Journal of immunology.

Consortium biology in immunology: the perspective from the Immunological Genome Project

C. Benoist, M. Merad, D. Mathis, 2014, Nature Reviews Immunology.

Mice Lacking Terminal Deoxynucleotidyl Transferase: Adult Mice with a Fetal Antigen Receptor Repertoire

C. Benoist, D. Mathis, S. Gilfillan, 1995, Immunological reviews.

Efficient immune responses in mice lacking N‐region diversity

R. Zinkernagel, C. Benoist, D. Mathis, 1995, European journal of immunology.

More efficient positive selection of thymocytes in mice lacking terminal deoxynucleotidyl transferase.

C. Benoist, D. Mathis, C. Waltzinger, 1994, International immunology.

A defective Il15 allele underlies the deficiency in natural killer cell activity in nonobese diabetic mice

C. Benoist, D. Mathis, Hirotsugu Suwanai, 2010, Proceedings of the National Academy of Sciences.

Targeted complementation of MHC class II deficiency by intrathymic delivery of recombinant adenoviruses.

C. Benoist, D. Mathis, C. Waltzinger, 1997, Immunity.

A molecular chart of thymocyte positive selection

C Benoist, C. Benoist, D. Mathis, 2001, European journal of immunology.

T cell anergy in perinatal mice is promoted by T reg cells and prevented by IL-33

C. Benoist, D. Mathis, J. Tuncel, 2019, The Journal of experimental medicine.

Altered Natural Killer Cells in Type 1 Diabetic Patients

Vincent L. Butty, C. Benoist, D. Mathis, 2007, Diabetes.

Distinct immunocyte-promoting and adipocyte-generating stromal components coordinate adipose tissue immune and metabolic tenors

C. Benoist, D. Mathis, D. Zemmour, 2019, Science Immunology.

Imbalanced signal transduction in regulatory T cells expressing the transcription factor FoxP3

C. Benoist, D. Mathis, M. Mingueneau, 2015, Proceedings of the National Academy of Sciences.

Denervation protects limbs from inflammatory arthritis via an impact on the microvasculature

R. Weissleder, C. Benoist, D. Mathis, 2014, Proceedings of the National Academy of Sciences.

CTLA-4 on thymic epithelial cells complements Aire for T cell central tolerance

C. Benoist, D. Mathis, Daniel A. Michelson, 2022, Proceedings of the National Academy of Sciences of the United States of America.

A special repertoire of alpha:beta T cells in neonatal mice.

C. Benoist, D. Mathis, M. Bogue, 1991, The EMBO journal.

Imaging the emergence and natural progression of spontaneous autoimmune diabetes

R. Weissleder, C. Benoist, D. Mathis, 2017, Proceedings of the National Academy of Sciences.

Aire Inhibits the Generation of a Perinatal Population of Interleukin-17A-Producing γδ T Cells to Promote Immunologic Tolerance.

C. Benoist, D. Mathis, S. Rosenzweig, 2016, Immunity.

Early window of diabetes determinism in NOD mice, dependent on the complement receptor CRIg, identified by noninvasive imaging

R. Weissleder, G. Wojtkiewicz, C. Benoist, 2012, Nature Immunology.

Autoimmune diabetes: Retrovirus as trigger, precipitator or marker?

C. Benoist, D. Mathis, 1997, Nature.

Transcriptional insights into the CD8[superscript +] T cell response to infection and memory T cell formation

Charles C. Kim, D. Koller, A. Regev, 2013 .

Impact of Diabetes Susceptibility Loci on Progression From Pre-Diabetes to Diabetes in At-Risk Individuals of the Diabetes Prevention Trial–Type 1 (DPT-1)

Vincent L. Butty, C. Benoist, D. Mathis, 2008, Diabetes.

Impact of diabetes susceptibility loci on progression from prediabetes to diabetes in at-risk individuals of the DPT 1 trial

Vincent L. Butty, C. Benoist, D. Mathis, 2008 .

Transcriptomes of the B and T Lineages Compared by Multiplatform Microarray Profiling

C. Benoist, D. Mathis, Michio W. Painter, 2011, Journal of Immunology.

Feyza Engin Protects Mice Against Type 1 Diabetes Cells β Restoration of the Unfolded Protein Response in Pancreatic

D. Mathis, D. Eizirik, Wenxian Fu, 2013 .

Sex-specific adipose tissue imprinting of regulatory T cells

David Chisanga, W. Shi, Yang Liao, 2020, Nature.

Tetracycline-controllable selection of CD4(+) T cells: half-life and survival signals in the absence of major histocompatibility complex class II molecules.

C Benoist, C. Benoist, D. Mathis, 2000, The Journal of experimental medicine.

Structure of the TCR-Ag-MHC Complex

C. Benoist, J. Peccoud, D. Mathis, 1992 .

Levees of immunological tolerance

C. Benoist, D. Mathis, 2010, Nature Immunology.

An interwoven network of transcription factors, with divergent influences from FoxP3, underlies Treg diversity

C. Benoist, D. Mathis, Deepshika Ramanan, 2023, bioRxiv.

Nonregulatory CD 4 Self-Peptides in Regulatory and Adaptation of TCR Repertoires to

C. Benoist, R. Obst, D. Mathis, 2007 .

Islet Recovery and Reversal of Murine Type 1 Diabetes in the Absence of Any Infused Spleen Cell Contribution

J. Gaglia, C. Benoist, D. Mathis, 2006, Science.

IL-17-producing T cells can augment autoantibody-induced arthritis

C. Benoist, J. Jacobs, D. Mathis, 2009, Proceedings of the National Academy of Sciences.

T-cell development: A new marker of differentiation state

C. Benoist, D. Mathis, 1999, Current Biology.

Amino Acids Specifying MHC Class Preference in TCR V a 2 Regions 1

C. Benoist, D. Mathis, C. Waltzinger, 1999 .

Positive selection of thymocytes induced by gene transfer: MHC class II-mediated selection of CD8 lineage cells.

C Benoist, C. Benoist, D. Mathis, 1999, International immunology.

Regulatory T cells in the face of the intestinal microbiota

C. Benoist, D. Mathis, Deepshika Ramanan, 2023, Nature Reviews Immunology.

Hnf4 activates mimetic-cell enhancers to recapitulate gut and liver development within the thymus

C. Benoist, D. Mathis, M. Verzi, 2023, The Journal of experimental medicine.

The major histocompatibility complex (MHC) Ea promoter: sequences and factors at the initiation site.

C. Benoist, D. Mathis, L. Tora, 1993, Nucleic acids research.

Selection for Survival?

C Benoist, C. Benoist, D. Mathis, 1997, Science.

Publisher Correction: Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR

Allon M. Klein, C. Benoist, R. Zilionis, 2018, Nature Immunology.

Altered I-J phenotype in E alpha transgenic mice.

C. Benoist, D. Mathis, D. Murphy, 1986, Proceedings of the National Academy of Sciences of the United States of America.

The same genomic region conditions clonal deletion and clonal deviation to the CD8alphaalpha and regulatory T cell lineages in NOD versus C57BL/6 mice.

C. Benoist, T. Yamagata, D. Mathis, 2007, Proceedings of the National Academy of Sciences of the United States of America.

The same systemic autoimmune disease provokes arthritis and endocarditis via distinct mechanisms

C. Benoist, R. Bronson, D. Mathis, 2009, Proceedings of the National Academy of Sciences.

TOXIC MHC CLASS II BETA CHAINS. AUTHORS' REPLY

C. Benoist, L. Fugger, D. Mathis, 1999 .

T-cell recognition of superantigens: inside or outside the groove?

C. Benoist, J. Peccoud, D. Mathis, 1989, Cold Spring Harbor symposia on quantitative biology.

Homeostatic, repertoire and transcriptional relationships between colon T regulatory cell subsets

C. Benoist, D. Mathis, Deepshika Ramanan, 2023, bioRxiv.

The Shaping of the T Cell Repertoire segments

C. Benoist, D. Mathis, C. Waltzinger, 2001 .

Regulation of major histocompatibility complex class-II genes: X, Y and other letters of the alphabet.

C. Benoist, D. Mathis, 1990 .

Expression profiling of constitutive mast cells reveals a unique identity within the immune system

A. Regev, C. Benoist, M. Merad, 2016, Nature Immunology.

ImmGen Report: Molecular definition of Natural Killer cell identity and activation

Charles C. Kim, A. Regev, V. Jojic, 2012, Nature Immunology.

Mutations from patients with IPEX ported to mice reveal different patterns of FoxP3 and Treg dysfunction

C. Benoist, D. Mathis, S. Hur, 2023, Cell reports.

Organismal immunometabolism: advances in both directions

D. Mathis, 2019, Nature Reviews Immunology.

Conservation and divergence in modules of the transcriptional programs of the human and mouse immune systems

Charles C. Kim, D. Koller, A. Regev, 2018, bioRxiv.

Genetic control of diabetes progression.

M. Mattéi, C. Benoist, D. Mathis, 1997, Immunity.

Poor Repair of Skeletal Muscle in Aging Mice Reflects a Defect in Local, Interleukin-33-Dependent Accumulation of Regulatory T Cells.

C. Benoist, D. Mathis, A. Wagers, 2016, Immunity.

Unstable FoxP3+ T regulatory cells in NZW mice

C. Benoist, D. Mathis, Ho-Keun Kwon, 2016, Proceedings of the National Academy of Sciences of the United States of America.

Treg cells, life history, and diversity.

C. Benoist, D. Mathis, 2012, Cold Spring Harbor perspectives in biology.

A comprehensive review of interventions in the NOD mouse and implications for translation.

R. Kahn, J. Bluestone, D. Mathis, 2005, Immunity.

Ectopic expression of peripheral-tissue antigens in the thymic epithelium: Probabilistic, monoallelic, misinitiated

C. Benoist, D. Mathis, Whitney Besse, 2008, Proceedings of the National Academy of Sciences.

A cluster of coregulated genes determines TGF-β–induced regulatory T-cell (Treg) dysfunction in NOD mice

C. Benoist, D. Mathis, A. D’Alise, 2011, Proceedings of the National Academy of Sciences.

Functional sites on the A alpha-chain. Polymorphic residues involved in antigen presentation to insulin-specific, Ab alpha:Ak beta-restricted T cells.

C. Benoist, J. Peccoud, D. Mathis, 1989, Journal of immunology.

Network pharmacology of JAK inhibitors

S. Mostafavi, C. Benoist, D. Mathis, 2016, Proceedings of the National Academy of Sciences.

Immunological contributions to adipose tissue homeostasis.

D. Mathis, J. DiSpirito, 2015, Seminars in immunology.

Initiation of Autoimmune Diabetes by Developmentally Regulated Presentation of Islet Cell Antigens in the Pancreatic Lymph Nodes

C. Benoist, D. Mathis, C. Waltzinger, 1999, The Journal of experimental medicine.

Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells.

P. Chambon, Y. Belkaid, C. Benoist, 2008, Immunity.

Neonatal tolerance revisited: a perinatal window for Aire control of autoimmunity

C. Benoist, D. Mathis, M. Martinic, 2009, The Journal of experimental medicine.

Knock-out mice: a new tool for transplantation immunologists.

C. Benoist, D. Mathis, S. Cardell, 1993, Transplantation proceedings.

Visualization of CD4/CD8 T Cell Commitment

C. Benoist, D. Mathis, A. Dierich, 1998, The Journal of experimental medicine.

Visualization of Cd4/cd8 T Cell Commitment

C. Benoist, D. Mathis, A. Dierich, 2022 .

Treg cells require Izumo1R to regulate γδT cell-driven inflammation in the skin

C. Benoist, D. Mathis, Y. Hsu, 2023, Proceedings of the National Academy of Sciences of the United States of America.

Parsing the Interferon Transcriptional Network and Its Disease Associations

Chun Jimmie Ye, N. Hacohen, A. Regev, 2016, Cell.

Differential Response of Regulatory and Conventional CD4+ Lymphocytes to CD3 Engagement: Clues to a Possible Mechanism of Anti-CD3 Action?

C. Benoist, D. Mathis, J. Nishio, 2013, The Journal of Immunology.

Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients.

J. Gaglia, R. Weissleder, M. Harisinghani, 2011, The Journal of clinical investigation.

The role of antibodies in mouse models of rheumatoid arthritis, and relevance to human disease.

C. Benoist, D. Mathis, P. Monach, 2004, Advances in immunology.

Regulatory T‐cell differentiation: Committed to control: a precocious choice?

C. Benoist, D. Mathis, S. Haxhinasto, 2007, Immunology and cell biology.

CD4 CD25 T Regulatory Cells Dependent on ICOS Promote Regulation of Effector Cells in the Prediabetic Lesion

C. Benoist, A. Herman, D. Mathis, 2004 .

Modifier loci condition autoimmunity provoked by Aire deficiency

Mark S. Anderson, C. Benoist, D. Mathis, 2005, The Journal of experimental medicine.

Where CD4+CD25+ T reg cells impinge on autoimmune diabetes

C. Benoist, Michael Matos, A. Herman, 2005, The Journal of experimental medicine.

Inhibition of thymocyte positive selection by natural MHC: peptide ligands

V. Kouskoff, C. Benoist, D. Mathis, 1999, European journal of immunology.

Local structure of a peptide contact site on Ak alpha.

C. Benoist, D. Mathis, G. Mer, 1991, International immunology.

The immunosuppressant 15-deoxyspergualin [correction of 1,5- deoxyspergualin] reveals commonality between preT and preB cell differentiation

C. Benoist, D. Mathis, Bo Wang, 1996, The Journal of experimental medicine.

The Immunosuppressant 1,5-deoxyspergualin Reveals Commonality between Pret and Preb Cell Differentiation

C. Benoist, D. Mathis, Bo Wang, 1996 .

Molecular diversification of regulatory T cells in nonlymphoid tissues

Allon M. Klein, C. Benoist, R. Zilionis, 2018, Science Immunology.

Prominent Role of RCS I-A in Syngeneic T Cell Stimulation 401

D. Mathis, G. Thorbecke, N. Ponzio, 2003 .

Inflammatory arthritis can be reined in by CpG-induced DC–NK cell cross talk

J. Carulli, R. Weissleder, C. Benoist, 2007, The Journal of experimental medicine.

Antigen persistence is required throughout the expansion phase of a CD4+ T cell response

C. Benoist, R. Obst, D. Mathis, 2005, The Journal of experimental medicine.

Interleukin-4 Deficiency Does Not Exacerbate Disease in NOD Mice

C. Benoist, D. Mathis, J. Katz, 1998, Diabetes.

Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire

C. Benoist, D. Mathis, D. Gray, 2007, The Journal of experimental medicine.

Genome-wide and species-wide dissection of the genetics of arthritis severity in heterogeneous stock mice.

J. Flint, W. Valdar, C. Benoist, 2011, Arthritis and rheumatism.

IL-17-producing T cells can augment autoantibody-induced arthritis

C. Benoist, J. Jacobs, D. Mathis, 2009, Proceedings of the National Academy of Sciences.

Positive selection of T cells: fastidious or promiscuous?

C. Benoist, D. Mathis, 1997, Current opinion in immunology.

Homeostatic, repertoire and transcriptional relationships between colon T regulatory cell subsets

C. Benoist, D. Mathis, Deepshika Ramanan, 2023, Proceedings of the National Academy of Sciences of the United States of America.

The major histocompatibility complex (MHC) Ea promoter: sequences and factors at the initiation site.

C. Benoist, D. Mathis, L. Tora, 1993, Nucleic acids research.