A. Varshavsky

发表

A Proteolytic Pathway That Recognizes Ubiquitin as a Degradation Signal (*)

I. Ota, Erica S. Johnson, P. Ma, 1995, The Journal of Biological Chemistry.

An Essential Role of N-Terminal Arginylation in Cardiovascular Development

A. Varshavsky, A. Kashina, Y. Kwon, 2002, Science.

The ubiquitin system.

Alexander Varshavsky, Aaron Ciechanover, Avram Hershko, 1998, Annual review of biochemistry.

Arginyltransferase, Its Specificity, Putative Substrates, Bidirectional Promoter, and Splicing-derived Isoforms*

C. S. Brower, A. Varshavsky, Y. Kwon, 2006, Journal of Biological Chemistry.

In vivo half-life of a protein is a function of its amino-terminal residue.

A. Varshavsky, D. Finley, A. Bachmair, 1986, Science.

Universality and structure of the N-end rule.

J. Tobias, William Arbuthnot Sir Lane, A. Varshavsky, 1989, The Journal of biological chemistry.

The N-end rule in bacteria.

J. Tobias, A. Varshavsky, T. Shrader, 1991, Science.

The N‐end rule pathway of protein degradation

A. Varshavsky, 1997, Genes to cells : devoted to molecular & cellular mechanisms.

‘Spalog’ and ‘sequelog’: neutral terms for spatial and sequence similarity

A. Varshavsky, 2004, Current Biology.

A gene encoding a putative tyrosine phosphatase suppresses lethality of an N-end rule-dependent mutant.

I. Ota, A. Varshavsky, 1992, Proceedings of the National Academy of Sciences of the United States of America.

RPN4 is a ligand, substrate, and transcriptional regulator of the 26S proteasome: A negative feedback circuit

A. Varshavsky, Youming Xie, A Varshavsky, 2001, Proceedings of the National Academy of Sciences of the United States of America.

N-Terminal Acetylation of Cellular Proteins Creates Specific Degradation Signals

Alexander Varshavsky, Cheol-Sang Hwang, A. Varshavsky, 2010, Science.

The N-end rule: functions, mysteries, uses.

A. Varshavsky, A Varshavsky, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Mapping proteinDNA interactions in vivo with formaldehyde: Evidence that histone H4 is retained on a highly transcribed gene

Alexander Varshavsky, A. Varshavsky, M. Solomon, 1988, Cell.

A yeast protein similar to bacterial two-component regulators.

I. Ota, A. Varshavsky, I M Ota, 1993, Science.

The ubiquitin system.

A. Varshavsky, A Varshavsky, 1997, Trends in biochemical sciences.

Degradation signals in the lysine–asparagine sequence space

A. Varshavsky, Tetsuro Suzuki, 1999, The EMBO journal.

The yeast polyubiquitin gene is essential for resistance to high temperatures, starvation, and other stresses

A. Varshavsky, D. Finley, Engin Özkaynak, 1987, Cell.

Calpain-generated natural protein fragments as short-lived substrates of the N-end rule pathway

A. Varshavsky, K. Piatkov, Jang-Hyun Oh, 2014, Proceedings of the National Academy of Sciences.

Amplification of specific DNA sequences correlates with multi-drug resistance in Chinese hamster cells

D. Housman, A. Varshavsky, I. Roninson, 1984, Nature.

Basic Medical Research Award. The ubiquitin system.

A. Ciechanover, A. Varshavsky, A. Hershko, 2000, Nature medicine.

Pairs of dipeptides synergistically activate the binding of substrate by ubiquitin ligase through dissociation of its autoinhibitory domain

A. Varshavsky, F. Du, Zanxian Xia, 2002, Proceedings of the National Academy of Sciences of the United States of America.

The Arg/N-degron pathway targets transcription factors and regulates specific genes

S. Gygi, A. Varshavsky, Tri T M Vu, 2020, Proceedings of the National Academy of Sciences.

The N-end rule pathway as a nitric oxide sensor controlling the levels of multiple regulators

A. Varshavsky, R. Hu, Zhenming Xu, 2005, Nature.

Mammalian cell cycle mutant defective in intracellular protein degradation and ubiquitin-protein conjugation.

A. Ciechanover, A. Varshavsky, D. Finley, 1985, Progress in clinical and biological research.

Split ubiquitin as a sensor of protein interactions in vivo.

A. Varshavsky, N. Johnsson, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Dissection of c‐MOS degron

A. Varshavsky, A. Kumagai, W. Dunphy, 2002, The EMBO journal.

Recognition of nonproline N-terminal residues by the Pro/N-degron pathway

J. Min, A. Varshavsky, Sara Weirich, 2020, Proceedings of the National Academy of Sciences.

Serine 228 is essential for catalytic activities of 85-kDa cytosolic phospholipase A2.

D. Brems, A. Varshavsky, J. Manetta, 1994, The Journal of biological chemistry.

Hypersensitivity to heavy water: A new conditional phenotype

A. Varshavsky, B. Bartel, 1988, Cell.

The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzyme

Alexander Varshavsky, S. Jentsch, A. Varshavsky, 1987, Nature.

The short-lived MATa 2 transcriptional regulator is ubiquitinated in vivo

A. Varshavsky, M. Hochstrasser, V. Chau, 2022 .

Crystal structure of the Ate1 arginyl-tRNA-protein transferase and arginylation of N-degron substrates

A. Varshavsky, H. Song, Min Kyung Kim, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Heat-inducible degron: a method for constructing temperature-sensitive mutants.

A. Varshavsky, P. Wu, Peipei Wu, 1994, Science.

Diadenosine 5′, 5′′′-P1, P4-tetraphosphate: a pleiotropically acting alarmone?

A. Varshavsky, 1983, Cell.

An Essential Yeast Gene Encoding a Homolog of Ubiquitin-activating Enzyme (*)

A. Goffeau, A. Varshavsky, R. Stappen, 1995, The Journal of Biological Chemistry.

The degradation signal in a short-lived protein

A. Varshavsky, A. Bachmair, 1989, Cell.

The N-end rule

A. Varshavsky, 1992, Cell.

The N-Terminal Methionine of Cellular Proteins as a Degradation Signal

A. Varshavsky, C. Hwang, Hanna Cho, 2014, Cell.

Degradation of the Separase-cleaved Rec8, a Meiotic Cohesin Subunit, by the N-end Rule Pathway*

C. S. Brower, A. Varshavsky, R. Hu, 2016, The Journal of Biological Chemistry.

The N-end rule pathway counteracts cell death by destroying proapoptotic protein fragments

C. S. Brower, A. Varshavsky, K. Piatkov, 2012, Proceedings of the National Academy of Sciences.

The N‐end rule pathway and regulation by proteolysis

A. Varshavsky, 2011, Protein science : a publication of the Protein Society.

The ubiquitin‐mediated proteolytic pathway and mechanisms of energy‐dependent intracellular protein degradation

A. Ciechanover, A. Varshavsky, D. Finley, 1984, Journal of cellular biochemistry.

Phorbol ester dramatically increases incidence of methotrexate-resistant mouse cells: Possible mechanisms and relevance to tumor promotion

A. Varshavsky, 1981, Cell.

Listeriolysin O Secreted by Listeria monocytogenes into the Host Cell Cytosol Is Degraded by the N-End Rule Pathway

A. Varshavsky, Jianmin Zhou, D. Portnoy, 2007, Infection and Immunity.

A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein.

D. Ecker, J. Tobias, A. Varshavsky, 1989, Science.

Molecular Genetics of the Ubiquitin System

S. Jentsch, M. Pazin, A. Varshavsky, 1988 .

The yeast cell cycle gene CDC34 encodes a ubiquitin-conjugating enzyme.

M. Goebl, S. Jentsch, A. Varshavsky, 1988, Science.

Glutamine-specific N-terminal amidase, a component of the N-end rule pathway.

C. S. Brower, A. Varshavsky, Haiqing Wang, 2009, Molecular cell.

Naming a targeting signal

A. Varshavsky, 1991, Cell.

A protein binds to a satellite DNA repeat at three specific sites that would be brought into mutual proximity by DNA folding in the nucleosome

A. Varshavsky, F. Strauss, 1984, Cell.

Substrate-binding Sites of UBR1, the Ubiquitin Ligase of the N-end Rule Pathway*

A. Varshavsky, F. Du, Zanxian Xia, 2008, Journal of Biological Chemistry.

The ubiquitin system: functions and mechanisms

A. Varshavsky, D. Finley, 1985 .

Peptides accelerate their uptake by activating a ubiquitin-dependent proteolytic pathway

A. Varshavsky, F. Du, Fangyong Du, 2000, Nature.

The N-end rule pathway is required for import of histidine in yeast lacking the kinesin-like protein Cin8p

A. Varshavsky, Youming Xie, 1999, Current Genetics.

The N‐end rule pathway controls the import of peptides through degradation of a transcriptional repressor

A. Varshavsky, C. Byrd, G. Turner, 1998, The EMBO journal.

Mouse Dfa Is a Repressor of TATA-box Promoters and Interacts with the Abt1 Activator of Basal Transcription*

C. S. Brower, A. Varshavsky, Richard H. Jones, 2010, The Journal of Biological Chemistry.

The N-end rule pathway in Xenopus egg extracts.

A. Varshavsky, I. Davydov, D. Patra, 1998, Archives of biochemistry and biophysics.

Amino Acids Induce Peptide Uptake via Accelerated Degradation of CUP9, the Transcriptional Repressor of the PTR2 Peptide Transporter*

A. Varshavsky, Zanxian Xia, C. Hwang, 2008, Journal of Biological Chemistry.

Targeting the absence: Homozygous DNA deletions as immutable signposts for cancer therapy

A. Varshavsky, 2007, Proceedings of the National Academy of Sciences.

Regulated protein degradation.

Alexander Varshavsky, A. Varshavsky, 2005, Trends in biochemical sciences.

The yeast ubiquitin genes: a family of natural gene fusions.

A. Varshavsky, M. Solomon, E. Ozkaynak, 1987, The EMBO journal.

The tails of ubiquitin precursors are ribosomal proteins whose fusion to ubiquitin facilitates ribosome biogenesis

Alexander Varshavsky, A. Varshavsky, B. Bartel, 1989, Nature.

Ubiquitin as a degradation signal.

A. Varshavsky, B. Bartel, W. Seufert, 1992, The EMBO journal.

The yeast ubiquitin gene: head-to-tail repeats encoding a polyubiquitin precursor protein

A. Varshavsky, D. Finley, Engin Özkaynak, 1984, Nature.

Ubiquitin-specific proteases of Saccharomyces cerevisiae. Cloning of UBP2 and UBP3, and functional analysis of the UBP gene family.

J. Tobias, A. Varshavsky, R. Baker, 1992, The Journal of biological chemistry.

Diadenosine 5',5'''-P/sup 1/, P/sup 4/-tetraphosphate: a pleiotropically acting alarmone

A. Varshavsky, 1983 .

On the cause of sleep: Protein fragments, the concept of sentinels, and links to epilepsy

A. Varshavsky, 2019, Proceedings of the National Academy of Sciences.

Cloning and functional analysis of the ubiquitin-specific protease gene UBP1 of Saccharomyces cerevisiae.

J. Tobias, A. Varshavsky, A Varshavsky, 1991, The Journal of biological chemistry.

A Family of Mammalian E3 Ubiquitin Ligases That Contain the UBR Box Motif and Recognize N-Degrons

Min Jae Lee, A. Varshavsky, Y. Kwon, 2005, Molecular and Cellular Biology.

Ubiquitin Ligases of the N-End Rule Pathway: Assessment of Mutations in UBR1 That Cause the Johanson-Blizzard Syndrome

H. Brunner, A. Varshavsky, J. Mayerle, 2011, PloS one.

Degradation of Serotonin N-Acetyltransferase, a Circadian Regulator, by the N-end Rule Pathway*

A. Varshavsky, J. Borjigin, Zheping Huang, 2016, The Journal of Biological Chemistry.

Detection of transient in vivo interactions between substrate and transporter during protein translocation into the endoplasmic reticulum.

A. Varshavsky, N. Johnsson, M. Dünnwald, 1999, Molecular biology of the cell.

A reference-based protein degradation assay without global translation inhibitors

A. Varshavsky, Jang-Hyun Oh, Shun-Jia Chen, 2017, The Journal of Biological Chemistry.

The N-end rule and regulation of apoptosis

A. Varshavsky, 2003, Nature Cell Biology.

Control of Hsp90 chaperone and its clients by N-terminal acetylation and the N-end rule pathway

A. Varshavsky, Jang-Hyun Oh, Ju-Yeon Hyun, 2017, Proceedings of the National Academy of Sciences.

Yeast N-terminal Amidase

A. Varshavsky, R. Baker, 1995, The Journal of Biological Chemistry.

Methotrexate Inhibits Proteolysis of Dihydrofolate Reductase by the N-end Rule Pathway (*)

Erica S. Johnson, A. Varshavsky, P. R. Waller, 1995, The Journal of Biological Chemistry.

Codominant interference, antieffectors, and multitarget drugs.

A. Varshavsky, A Varshavsky, 1998, Proceedings of the National Academy of Sciences of the United States of America.

N-degron and C-degron pathways of protein degradation

A. Varshavsky, 2019, Proceedings of the National Academy of Sciences.

The ubiquitin system, an immense realm.

Alexander Varshavsky, A. Varshavsky, 2012, Annual review of biochemistry.

Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85

A. Ciechanover, A. Varshavsky, D. Finley, 1984, Cell.

UBA 1: an essential yeast gene encoding ubiquitin‐activating enzyme.

S. Jentsch, A. Varshavsky, J. P. McGrath, 1991, The EMBO journal.

Degradation of a cohesin subunit by the N-end rule pathway is essential for chromosome stability

K. Nasmyth, A. Varshavsky, F. Uhlmann, 2001, Nature.

Discovery of Cellular Regulation by Protein Degradation

A. Varshavsky, 2008, Journal of Biological Chemistry.

The E2–E3 interaction in the N‐end rule pathway: the RING‐H2 finger of E3 is required for the synthesis of multiubiquitin chain

A. Varshavsky, Youming Xie, 1999, The EMBO journal.

Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome)

M. Rauh, R. Gershoni-baruch, G. Hülskamp, 2005, Nature Genetics.

The auto-generated fragment of the Usp1 deubiquitylase is a physiological substrate of the N-end rule pathway.

A. Varshavsky, M. Békés, Tony T. Huang, 2012, Molecular cell.

Formyl-methionine as a degradation signal at the N-termini of bacterial proteins

A. Varshavsky, C. Hwang, K. Piatkov, 2015, Microbial cell.

Formyl-methionine as an N-degron of a eukaryotic N-end rule pathway

A. Varshavsky, Cheolju Lee, Joo-Yeon Yoo, 2018, Science.

Cdc48p interacts with Ufd3p, a WD repeat protein required for ubiquitin‐mediated proteolysis in Saccharomyces cerevisiae.

A. Varshavsky, R. Dohmen, F. Lévy, 1996, The EMBO journal.

Altered Activity, Social Behavior, and Spatial Memory in Mice Lacking the NTAN1p Amidase and the Asparagine Branch of the N-End Rule Pathway

V. Denenberg, A. Varshavsky, A. Kashina, 2000, Molecular and Cellular Biology.

A Mouse Amidase Specific for N-terminal Asparagine

S. Arfin, N. Jenkins, A. Varshavsky, 1996, The Journal of Biological Chemistry.

RECQL4, mutated in the Rothmund-Thomson and RAPADILINO syndromes, interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway.

A. Varshavsky, Weidong Wang, Y. Kwon, 2004, Human molecular genetics.

Ubiquitin‐assisted dissection of protein transport across membranes.

A. Varshavsky, N. Johnsson, Nils Johnsson, 1994, The EMBO journal.

Neurodegeneration-associated protein fragments as short-lived substrates of the N-end rule pathway.

C. S. Brower, A. Varshavsky, K. Piatkov, 2013, Molecular cell.

In vivo degradation of a transcriptional regulator: The yeast α2 repressor

Alexander Varshavsky, A. Varshavsky, M. Hochstrasser, 1990, Cell.

The Ubiquitin System, Autophagy, and Regulated Protein Degradation.

Alexander Varshavsky, A. Varshavsky, 2017, Annual review of biochemistry.

Analyzing N-terminal Arginylation through the Use of Peptide Arrays and Degradation Assays*

C. S. Brower, A. Varshavsky, K. Piatkov, 2016, The Journal of Biological Chemistry.

The recognition component of the N‐end rule pathway.

A. Varshavsky, B. Bartel, I. Wünning, 1990, The EMBO journal.

Aminopeptidases trim Xaa-Pro proteins, initiating their degradation by the Pro/N-degron pathway

A. Varshavsky, H. Song, L. Kim, 2021, Proceedings of the National Academy of Sciences.

The ATF3 Transcription Factor Is a Short-Lived Substrate of the Arg/N-Degron Pathway.

A. Varshavsky, Tri T M Vu, 2020, Biochemistry.

Five enzymes of the Arg/N-degron pathway form a targeting complex: The concept of superchanneling

A. Varshavsky, Jang-Hyun Oh, Shun-Jia Chen, 2020, Proceedings of the National Academy of Sciences.

Evolution of Substrates and Components of the Pro/N-Degron Pathway.

A. Varshavsky, A. Melnykov, Shun-Jia Chen, 2020, Biochemistry.

Gid10 as an alternative N-recognin of the Pro/N-degron pathway

A. Varshavsky, A. Melnykov, Shun-Jia Chen, 2019, Proceedings of the National Academy of Sciences.

Understanding the Pro/N-end rule pathway

A. Varshavsky, D. Dougan, 2018, Nature Chemical Biology.

An N-end rule pathway that recognizes proline and destroys gluconeogenic enzymes

Alexander Varshavsky, A. Varshavsky, Xia Wu, 2017, Science.

Ubiquitin Reference Technique and Its Use in Ubiquitin-Lacking Prokaryotes

A. Varshavsky, E. Graciet, K. Piatkov, 2013, PloS one.

Control of protein quality and stoichiometries by N-terminal acetylation and the N-end rule pathway.

A. Varshavsky, C. Hwang, Anna Shemorry, 2013, Molecular cell.

The N-end rule pathway is mediated by a complex of the RING-type Ubr1 and HECT-type Ufd4 ubiquitin ligases

Daniel Auerbach, Alexander Varshavsky, Cheol-Sang Hwang, 2010, Nature Cell Biology.

The N-end rule is mediated by the UBC2(RAD6) ubiquitin-conjugating enzyme.

A. Varshavsky, B. Bartel, K. Madura, 1991, Proceedings of the National Academy of Sciences of the United States of America.

The Origins of the Ubiquitin Field

A. Varshavsky, 2006 .

The early history of the ubiquitin field

A. Varshavsky, 2006, Protein science : a publication of the Protein Society.

Ubiquitin as a central cellular regulator

A. Ciechanover, A. Varshavsky, D. Finley, 2004, Cell.

Ubiquitin-mediated protein degradation: The early days The ubiquitin system

A. Ciechanover, A. Varshavsky, A. Hershko, 2000 .

Control of mammalian G protein signaling by N-terminal acetylation and the N-end rule pathway

A. Varshavsky, Jeong-Mok Kim, C. Hwang, 2015, Science.

The N-end rule at atomic resolution

A. Varshavsky, 2008, Nature Structural &Molecular Biology.

Using ubiquitin to follow the metabolic fate of a protein.

A. Varshavsky, N. Johnsson, F. Lévy, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Detecting and measuring cotranslational protein degradation in vivo.

A. Varshavsky, A Varshavsky, G C Turner, 2000, Science.

Unified nomenclature for subunits of the Saccharomyces cerevisiae proteasome regulatory particle.

H. Feldmann, L. Frontali, P. Silver, 1998, Trends in biochemical sciences.

Three decades of studies to understand the functions of the ubiquitin family.

A. Varshavsky, 2012, Methods in molecular biology.

Duration of Nuclear NF-kB Action Regulated by Reversible Acetylation

M. Tyers, I. Ota, A. Varshavsky, 2001 .

Analysis of a conditional degradation signal in yeast and mammalian cells.

A. Varshavsky, F. Lévy, J. A. Johnston, 1999, European journal of biochemistry.

The short-lived MAT alpha 2 transcriptional regulator is ubiquitinated in vivo.

A. Varshavsky, M. Hochstrasser, V. Chau, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Two proteolytic pathways regulate DNA repair by cotargeting the Mgt1 alkylguanine transferase

A. Varshavsky, C. Hwang, Anna Shemorry, 2009, Proceedings of the National Academy of Sciences.

Ubiquitin fusion technique and related methods.

A. Varshavsky, 2005, Methods in enzymology.

Ubiquitin fusion technique and its descendants.

A. Varshavsky, 2000, Methods in enzymology.

Augmented generation of protein fragments during wakefulness as the molecular cause of sleep: a hypothesis

A. Varshavsky, 2012, Protein science : a publication of the Protein Society.

Alternative Splicing Results in Differential Expression, Activity, and Localization of the Two Forms of Arginyl-tRNA-Protein Transferase, a Component of the N-End Rule Pathway

Yong Tae Kwon, Alexander Varshavsky, A. Varshavsky, 1999, Molecular and Cellular Biology.

Ablation of Arginylation in the Mouse N-End Rule Pathway: Loss of Fat, Higher Metabolic Rate, Damaged Spermatogenesis, and Neurological Perturbations

C. S. Brower, A. Varshavsky, 2009, PloS one.

The N-end rule is mediated by the UBC 2 ( RAD 6 ) ubiquitin-conjugating enzyme ( protein degradation / yeast / RAD 6 / UBC 2 )

A. Varshavsky, B. Bartel, K. Madura, 2022 .

The N-End Rule of Selective Protein Turnover

A. Varshavsky, D. Finley, A. Bachmair, 1988 .

The N-end rule of selective protein turnover: mechanistic aspects and functional implications.

A. Varshavsky, D. Finley, A. Bachmair, 1987, Biochemical Society transactions.

Female Lethality and Apoptosis of Spermatocytes in Mice Lacking the UBR2 Ubiquitin Ligase of the N-End Rule Pathway

A. Varshavsky, Y. Kwon, I. Davydov, 2003, Molecular and Cellular Biology.

The mouse and human genes encoding the recognition component of the N-end rule pathway.

N. Copeland, N. Jenkins, A. Varshavsky, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Construction and Analysis of Mouse Strains Lacking the Ubiquitin Ligase UBR1 (E3α) of the N-End Rule Pathway

A. Varshavsky, Y. Kwon, I. Davydov, 2001, Molecular and Cellular Biology.

The yeast STE6 gene encodes a homologue of the mammalian multidrug resistance P-glycoprotein

A. Varshavsky, J. Mcgrath, 1989, Nature.

The N-end rule in Escherichia coli: cloning and analysis of the leucyl, phenylalanyl-tRNA-protein transferase gene aat

J. Tobias, A. Varshavsky, T. E. Shrader, 1993, Journal of bacteriology.

TheN-EndRuleinEscherichia coli: Cloning andAnalysis of theLeucyl, Phenylalanyl-tRNA-Protein Transferase Geneaat

A. Varshavsky, 1993 .

Recent studies of the ubiquitin system and the N-end rule pathway.

A. Varshavsky, 2000, Harvey lectures.

In vivo degradation of a transcriptional regulator: the yeast alpha 2 repressor.

A. Varshavsky, M. Hochstrasser, 1990, Cell.

Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85

A. Ciechanover, A. Varshavsky, D. Finley, 1984, Cell.

RGS4 Is Arginylated and Degraded by the N-end Rule Pathway in Vitro *

A. Varshavsky, I. Davydov, 2000, The Journal of Biological Chemistry.

Physical association of ubiquitin ligases and the 26S proteasome.

A. Varshavsky, Youming Xie, Y. Xie, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Degradation of G alpha by the N-end rule pathway.

A. Varshavsky, K. Madura, 1994, Science.

Liat1, an arginyltransferase-binding protein whose evolution among primates involved changes in the numbers of its 10-residue repeats

C. S. Brower, A. Varshavsky, C. Rosen, 2014, Proceedings of the National Academy of Sciences.

Discovery of the biology of the ubiquitin system.

A. Varshavsky, 2014, JAMA.

The N-end rule pathway controls multiple functions during Arabidopsis shoot and leaf development

A. Varshavsky, E. Meyerowitz, F. Wellmer, 2009, Proceedings of the National Academy of Sciences.

Biochemical and Genetic Studies of UBR3, a Ubiquitin Ligase with a Function in Olfactory and Other Sensory Systems*

R. Hellweg, A. Varshavsky, Y. Kwon, 2007, Journal of Biological Chemistry.

Aminoacyl-transferases and the N-end rule pathway of prokaryotic/eukaryotic specificity in a human pathogen.

J. Rhee, E. Schwarz, A. Varshavsky, 2006, Proceedings of the National Academy of Sciences of the United States of America.

The Ubiquitin System and the N-End Rule Pathway

A. Varshavsky, F. Du, Youming Xie, 2000 .

Bivalent Inhibitor of the N-end Rule Pathway*

A. Varshavsky, Y. Kwon, F. Lévy, 1999, The Journal of Biological Chemistry.

The N-end rule pathway is a sensor of heme

A. Varshavsky, R. Hu, Zanxian Xia, 2008, Proceedings of the National Academy of Sciences.

N-recognin/Ubc2 interactions in the N-end rule pathway.

A. Varshavsky, K. Madura, R. Dohmen, 1993, The Journal of biological chemistry.

UFD4 lacking the proteasome-binding region catalyses ubiquitination but is impaired in proteolysis

A. Varshavsky, Youming Xie, 2002, Nature Cell Biology.

Deletions of DNA in cancer and their possible uses for therapy

A. Varshavsky, K. Lewis, Shun-Jia Chen, 2023, BioEssays : news and reviews in molecular, cellular and developmental biology.

Impaired neurogenesis and cardiovascular development in mice lacking the E3 ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway.

Min Jae Lee, A. Varshavsky, Y. Kwon, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Enzymatic N‐terminal Addition of Noncanonical Amino Acids to Peptides and Proteins

A. Varshavsky, D. Tirrell, R. E. Connor, 2008, Chembiochem : a European journal of chemical biology.

Regulation of peptide import through phosphorylation of Ubr1, the ubiquitin ligase of the N-end rule pathway

A. Varshavsky, C. Hwang, 2008, Proceedings of the National Academy of Sciences.

Cloning and functional analysis of the arginyl-tRNA-protein transferase gene ATE1 of Saccharomyces cerevisiae.

A. Goffeau, E. Balzi, A. Varshavsky, 1990, The Journal of biological chemistry.

The N-end rule.

A. Varshavsky, 1995, Cold Spring Harbor symposia on quantitative biology.

Hierarchical modeling of phenolic ligand binding to 2Zn--insulin hexamers.

J. M. Beals, A. Varshavsky, B. Saxberg, 1996, Biochemistry.

Corrigendum: Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome)

M. Rauh, A. Ekici, R. Gershoni-baruch, 2006, Nature Genetics.

The ubiquitin system

A. Ciechanover, A. Varshavsky, A. Hershko, 2000, Nature Medicine.

The ubiquitin system.

A. Varshavsky, 1997, Trends in biochemical sciences.

Control of mammalian G protein signaling by N-terminal acetylation and the N-end rule pathway

A. Varshavsky, Jeong-Mok Kim, C. Hwang, 2015, Science.

Inhibition of the N-end rule pathway in living cells.

A. Varshavsky, R. Baker, 1991, Proceedings of the National Academy of Sciences of the United States of America.

The N-Terminal Methionine of Cellular Proteins as a Degradation Signal

A. Varshavsky, C. Hwang, Hanna Cho, 2014, Cell.

Listeriolysin O Secreted by Listeria monocytogenes into the Host Cell Cytosol Is Degraded by the N-End Rule Pathway

A. Varshavsky, Jianmin Zhou, D. Portnoy, 2007, Infection and Immunity.

Daniel A. Portnoy Is Degraded by the N-end Rule Pathway into the Host Cell Cytosol Monocytogenes Listeria Listeriolysin O Secreted By

A. Varshavsky, Jianmin Zhou, P. Schnupf, 2007 .

Felix Hoppe-Seyler Lecture 2000. The ubiquitin system and the N-end rule pathway.

A. Varshavsky, F. Du, G. Turner, 2000, Biological chemistry.

Discovery of the biology of the ubiquitin system.

A. Varshavsky, 2014, JAMA.

The auto-generated fragment of the Usp1 deubiquitylase is a physiological substrate of the N-end rule pathway.

A. Varshavsky, M. Békés, Tony T. Huang, 2012, Molecular cell.