Simeon I. Taylor

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Identification of a Family of Sorting Nexin Molecules and Characterization of Their Association with Receptors

D. Haft, C. Haft, M. de la Luz Sierra, 1998, Molecular and Cellular Biology.

transfected rat adipose cells. ras in regulating translocation of GLUT4 in Roles of 1-phosphatidylinositol 3-kinase and

M. Kasuga, Hui Chen, M. Quon, 2013 .

Diabetes mellitus : a fundamental and clinical text

Jerrold M. Olefsky, Derek LeRoith, Simeon I. Taylor, 2004 .

Intensive, long-term plasma exchange therapy for severe hypertriglyceridemia in acquired generalized lipoatrophy.

Simeon I. Taylor, P. Gorden, S. Leitman, 2002, The Journal of clinical endocrinology and metabolism.

Insulin Access and Affordability Working Group: Conclusions and Recommendations

W. Herman, Simeon I. Taylor, W. Cefalu, 2018, Diabetes Care.

Sodium–Glucose Cotransporter 2 Inhibitors: A Case Study in Translational Research

Simeon I. Taylor, A. Beitelshees, B. Leslie, 2019, Diabetes.

Ketoacidosis associated with SGLT2 inhibitor treatment: Analysis of FAERS data

Simeon I. Taylor, K. Rother, J. Blau, 2017, Diabetes/metabolism research and reviews.

When translation meets metabolism: multiple links to diabetes.

N. Sonenberg, Seng-Lai Tan, Simeon I. Taylor, 2003, Endocrine reviews.

Individualized Glycemic Goals for Older Adults Are a Moving Target.

Simeon I. Taylor, S. Pilla, Zhinous Shahidzadeh Yazdi, 2022, Diabetes care.

Familial Hypercholesterolemia and Type 2 Diabetes in the Old Order Amish

E. Zeggini, A. Shuldiner, B. Mitchell, 2017, Diabetes.

Metabolic syndrome: an ill wind that blows some good?

Simeon I. Taylor, 2015, Diabetes/metabolism research and reviews.

Mutations in Insulin-Receptor Gene in Insulin-Resistant Patients

D. Accili, Simeon I. Taylor, T. Kadowaki, 1990, Diabetes Care.

YIPF5 mutations cause neonatal diabetes and microcephaly: progress for precision medicine and mechanistic understanding.

Simeon I. Taylor, T. Pollin, 2020, The Journal of clinical investigation.

sgk: an essential convergence point for peptide and steroid hormone regulation of ENaC-mediated Na+ transport.

Simeon I. Taylor, B. Blazer-Yost, N. Perrotti, 2002, American journal of physiology. Cell physiology.

Molecular Scanning of β-3-Adrenergic Receptor Gene in Total Congenital Lipoatrophic Diabetes Mellitus

K. Silver, C. Kahn, A. Shuldiner, 1997 .

11 Insulin receptors in normal and disease states

G. Grunberger, Simeon I. Taylor, P. Gorden, 1983 .

SodiumGlucose Cotransporter-2 Inhibitors: Lack of a Complete History Delays Diagnosis

Simeon I. Taylor, B. Leslie, L. Gerwin, 2019, Annals of Internal Medicine.

Homozygous deletion of the human insulin receptor gene results in leprechaunism

Simeon I. Taylor, P. Backeljauw, E. Wertheimer, 1993, Nature Genetics.

Increased usual physical activity is associated with a blunting of the triglyceride response to a high-fat meal.

A. Shuldiner, N. Steinle, B. Mitchell, 2019, Journal of clinical lipidology.

Diabetic ketoacidosis, sodium glucose transporter-2 inhibitors and the kidney.

Simeon I. Taylor, D. Clegg, M. Weir, 2016, Journal of diabetes and its complications.

The complicated clinical course in a case of atypical lipodystrophy after development of neutralizing antibody to metreleptin: treatment with setmelanotide

M. Westerhoff, Simeon I. Taylor, F. DiPaola, 2020, Endocrinology, diabetes & metabolism case reports.

SGLT2i Improves Glycemic Control in Patients With Congenital Severe Insulin Resistance.

W. Tamborlane, Simeon I. Taylor, F. Barbetti, 2022, Pediatrics.

Clinical Course of the Syndrome of Autoantibodies to the Insulin Receptor (Type B Insulin Resistance): A 28-Year Perspective

Simeon I. Taylor, P. Gorden, E. Arioglu, 2002, Medicine.

SGLT2-inhibitors Trigger Downstream Mechanisms That May Exert Adverse Effects Upon Bone

Simeon I. Taylor, K. Rother, J. Blau, 2016 .

Clinical Disorders Associated with Autoantibodies

Simeon I. Taylor, P. Gorden, S. Chernick, 1983 .

COMMENTARY Genetically Defined Forms of Diabetes in Children

Simeon I. Taylor, E. Arioglu, 1999 .

Chapter 15 - Molecular Mechanisms in the Pathophysiology of Noninsulin-Dependent Diabetes Mellitus:: Insulin Resistance and Insulin Deficiency

Simeon I. Taylor, 1997 .

Receptor Defects in Genetic Forms of Extreme Insulin Resistance

Simeon I. Taylor, 1984 .

Leprechaunism and homozygous nonsense mutation In the insulin receptor gene

Simeon I. Taylor, J. Hone, S. Mitton, 1993, The Lancet.

Mutations of the human insulin receptor gene

D. Accili, Simeon I. Taylor, T. Kadowaki, 1990, Trends in Endocrinology & Metabolism.

Adverse effects of SGLT2 inhibitors on bone health

Simeon I. Taylor, J. Blau, 2018, Nature Reviews Nephrology.

The Dual Peroxisome Proliferator-Activated Receptor (cid:1) / (cid:2) Activator Muraglitazar Prevents the Natural Progression of Diabetes in db/db Mice

Simeon I. Taylor, E. Janovitz, E. Tozzo, 2007 .

Lipoatrophy Revisited

M. Reitman, Simeon I. Taylor, O. Gavrilova, 2000, Trends in Endocrinology & Metabolism.

Detection of Mutations in Insulin Receptor Gene by Denaturing Gradient Gel Electrophoresis

E. Bonora, Simeon I. Taylor, P. Gejman, 1992, Diabetes.

A Novel Human Insulin Receptor Gene Mutation Uniquely Inhibits Insulin Binding Without Impairing Posttranslational Processing

D. Accili, Simeon I. Taylor, P. Formisano, 1994, Diabetes.

Cell Surface Alteration in Epstein-Barr Virus-Transformed Cells From Patients With Extreme Insulin Resistance

Simeon I. Taylor, J. Carpentier, D. Gorden, 1990, Diabetes.

SGLT2 Inhibitors as Adjunctive Therapy for Type 1 Diabetes: Balancing Benefits versus Risks

Simeon I. Taylor, A. Beitelshees, K. Rother, 2019 .

Insulin-Receptor Biosynthesis in Cultured Lymphocytes From an Insulin-Resistant Patient (Rabson-Mendenhall Syndrome): Evidence for Defect Before Insertion of Receptor Into Plasma Membrane

Simeon I. Taylor, M. Serrano-Ríos, J. A. Hedo, 1986, Diabetes.

Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy.

K. Petersen, S. Dufour, D. Befroy, 2002, The Journal of clinical investigation.

Monocyte DPP4 Expression in Human Atherosclerosis Is Associated With Obesity and Dyslipidemia

S. Rajagopalan, M. Quon, Simeon I. Taylor, 2017, Diabetes Care.

Efficacy and Safety of Troglitazone in the Treatment of Lipodystrophy Syndromes

J. Hoofnagle, M. Reitman, Simeon I. Taylor, 2000, Annals of Internal Medicine.

INSULIN-INDUCED PHOSPHORYLATION OF INSULIN RECEPTORS AND INSULIN RECEPTOR SUBSTRATE-1 DISPLACES PHOSPHORYLATED PLATELET-DERIVED GROWTH FACTOR RECEPTORS FROM BINDING SITES ON PI 3-KINASE*

Simeon I. Taylor, R. Levy-Toledano, W. Larochelle, 1995 .

Treatment of Lipodystrophy with Troglitazone

Simeon I. Taylor, E. Arioglu, 2001 .

Development of a Novel Polygenic Model of NIDDM in Mice Heterozygous for IR and IRS-1 Null Alleles

C. Kahn, D. Accili, S. Bonner-Weir, 1997, Cell.

Clinical Course of Genetic Diseases of the Insulin Receptor (Type A and Rabson-Mendenhall Syndromes): A 30-Year Prospective

Simeon I. Taylor, P. Gorden, M. Skarulis, 2004, Medicine.

Biosynthesis of ergosta-4,6,8(14),22-tetraen-3-one. A novel oxygenative pathway

Simeon I. Taylor, J. D. White, Dennis W. Perkins, 1973 .

Paradoxical biological effects of overexpressed insulin‐like growth factor‐1 receptors in chinese hamster ovary cells

Simeon I. Taylor, C. Roberts, D. Leroith, 1993, Journal of cellular physiology.

Lipoatrophy syndromes: when ‘too little fat’ is a clinical problem

M. Reitman, Simeon I. Taylor, K. Rother, 2000, Pediatric diabetes.

Leptin-replacement therapy for lipodystrophy.

M. Reitman, Simeon I. Taylor, A. Garg, 2002, The New England journal of medicine.

CHAPTER 5 – Mechanism of Action of Hormones That Act at the Cell Surface

Simeon I. Taylor, R. Kulkarni, C. Carter-Su, 2011 .

Proximal Enhancer of the Human Insulin Receptor Gene Binds the Transcription Factor Sp1

Hui Chen, Simeon I. Taylor, S. Taylor, 1994, Diabetes.

Tyrosine Phosphorylation of Insulin Receptor Substrate-1 in Vivo Depends upon the Presence of Its Pleckstrin Homology Region (*)

D. Accili, Simeon I. Taylor, Y. Zick, 1995, The Journal of Biological Chemistry.

Deletion of interleukin 1 receptor-associated kinase 1 (Irak1) improves glucose tolerance primarily by increasing insulin sensitivity in skeletal muscle

M. Quon, Simeon I. Taylor, R. Henry, 2017, The Journal of Biological Chemistry.

Characterization of Drosophila Insulin Receptor Substrate*

Pin Xu, C. Haft, Simeon I. Taylor, 2000, The Journal of Biological Chemistry.

Interaction of Insulin Receptor Substrate 3 with Insulin Receptor, Insulin Receptor-related Receptor, Insulin-like Growth Factor-1 Receptor, and Downstream Signaling Proteins*

Pin Xu, Simeon I. Taylor, A. R. Jacobs, 1999, The Journal of Biological Chemistry.

Syndromes Associated with Insulin Resistance and Acanthosis Nigricans

Simeon I. Taylor, E. Arioglu, Elif Arioglu,, 1998, Journal of basic and clinical physiology and pharmacology.

Insulin signal transduction pathways

A. Butte, M. Quon, Simeon I. Taylor, 1994, Trends in Endocrinology & Metabolism.

Lilly Lecture: Molecular Mechanisms of Insulin Resistance: Lessons From Patients With Mutations in the Insulin-Receptor Gene

Simeon I. Taylor, S. Taylor, 1992, Diabetes.

Insulin Resistance or Insulin Deficiency: Which Is the Primary Cause of NIDDM?

D. Accili, Simeon I. Taylor, Y. Imai, 1994, Diabetes.

Overexpression of a Novel Sorting Nexin, SNX15, Affects Endosome Morphology and Protein Trafficking

C. Haft, V. Barr, Simeon I. Taylor, 2000, Traffic.

Early neonatal death in mice homozygous for a null allele of the insulin receptor gene

Mark D. Johnson, D. Accili, Simeon I. Taylor, 1996, Nature Genetics.

Activation of Serum- and Glucocorticoid-induced Protein Kinase (Sgk) by Cyclic AMP and Insulin*

C. Haft, Simeon I. Taylor, S. Phillips, 2001, The Journal of Biological Chemistry.

Subcellular Localization and Internalization of the Four Human Leptin Receptor Isoforms*

V. Barr, Simeon I. Taylor, Kimberly T. Lane, 1999, The Journal of Biological Chemistry.

Human biallelic MFN2 mutations induce mitochondrial dysfunction, upper body adipose hyperplasia, and suppression of leptin expression

T. Hansen, O. Pedersen, S. O’Rahilly, 2017, eLife.

Normal Coding Sequence of Insulin Gene in Pima Indians and Nauruans, Two Groups With Highest Prevalence of Type II Diabetes

S. Lillioja, P. Zimmet, Simeon I. Taylor, 1991, Diabetes.

Genetic and functional evidence relates a missense variant in B4GALT1 to lower LDL-C and fibrinogen

May E. Montasser, G. D. Gatta, J. O’Connell, 2019, bioRxiv.

AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34

A. Bowcock, Simeon I. Taylor, A. Garg, 2002, Nature Genetics.

Familial lipodystrophy associated with neurodegeneration and congenital cataracts

Simeon I. Taylor, J. Berger, Elif Arioglu Oral, 2002, Neurology.

Lipoatrophic-Lipodystrophic Syndromes: The Spectrum

Simeon I. Taylor, C. Chow, A. Premkumar, 2002 .

Does Leptin Contribute to Diabetes Caused by Obesity?

M. Reitman, V. Barr, Simeon I. Taylor, 1996, Science.

Rat liver membranes contain a 120 kDa glycoprotein which serves as a substrate for the tyrosine kinases of the receptors for insulin and epidermal growth factor

Simeon I. Taylor, S. Taylor, S. Phillips, 1987, FEBS letters.

Sorting Nexin 6, a Novel SNX, Interacts with the Transforming Growth Factor-β Family of Receptor Serine-Threonine Kinases*

A. Roberts, J. McNally, Simeon I. Taylor, 2001, The Journal of Biological Chemistry.

Possible adverse effects of SGLT2 inhibitors on bone.

Simeon I. Taylor, K. Rother, J. Blau, 2015, The lancet. Diabetes & endocrinology.

Mutagenesis of Phe381 and Phe382 in the extracellular domain of the insulin receptor: effects on receptor biosynthesis, processing, and ligand‐dependent internalization

A. Ullrich, D. Accili, Simeon I. Taylor, 1994, FEBS letters.

Identification and Characterization of SNX15, a Novel Sorting Nexin Involved in Protein Trafficking*

D. Haft, V. Barr, Simeon I. Taylor, 2001, The Journal of Biological Chemistry.

Pharmacological treatment of hyperglycemia in type 2 diabetes.

Simeon I. Taylor, A. Beitelshees, Zhinous Shahidzadeh Yazdi, 2021, The Journal of clinical investigation.

SGLT2 Inhibitors May Predispose to Ketoacidosis.

Simeon I. Taylor, K. Rother, J. Blau, 2015, The Journal of clinical endocrinology and metabolism.

Canagliflozin triggers the FGF23/1,25-dihydroxyvitamin D/PTH axis in healthy volunteers in a randomized crossover study.

Simeon I. Taylor, K. Rother, A. Courville, 2018, JCI insight.

Homozygosity for a null allele of the insulin receptor gene in a patient with leprechaunism

D. Accili, Simeon I. Taylor, S. Taylor, 1995, Human mutation.

Two Patients With Insulin Resistance Due to Decreased Levels of Insulin-Receptor mRNA

Simeon I. Taylor, T. Kadowaki, R. Kawamori, 1991, Diabetes.

The Dual Peroxisome Proliferator-Activated Receptor α/γ Activator Muraglitazar Prevents the Natural Progression of Diabetes in db/db Mice

Simeon I. Taylor, E. Janovitz, E. Tozzo, 2007, Journal of Pharmacology and Experimental Therapeutics.

The dual peroxisome proliferator-activated receptor alpha/gamma activator muraglitazar prevents the natural progression of diabetes in db/db mice.

Simeon I. Taylor, E. Janovitz, E. Tozzo, 2007, The Journal of pharmacology and experimental therapeutics.

Canagliflozin triggers the FGF 23 / 1 , 25-dihydroxyvitamin D / PTH axis in healthy volunteers in a randomized crossover study

Simeon I. Taylor, K. Rother, A. Courville, 2018 .

Effect of Leptin Administration on Circulating Apolipoprotein CIII levels in Patients With Lipodystrophy.

R. Muniyappa, Simeon I. Taylor, P. Gorden, 2016, The Journal of clinical endocrinology and metabolism.

SGLT2 inhibitors as adjunctive therapy for type 1 diabetes: balancing benefits and risks.

Simeon I. Taylor, A. Beitelshees, K. Rother, 2019, The lancet. Diabetes & endocrinology.

Cardiovascular outcome trials of diabetes drugs: lessons learned

Simeon I. Taylor, B. Leslie, 2018, The Journal of clinical investigation.

Insulin Receptors in Developing Rat Liver

D. Seminara, R. Margolis, Simeon I. Taylor, 1990 .

Smarter Modeling to Enable a Smarter Insulin

Simeon I. Taylor, R. DiMarchi, 2020, Diabetes.

The High Cost of Diabetes Drugs: Disparate Impact on the Most Vulnerable Patients

Simeon I. Taylor, 2020, Diabetes Care.

Unique Features of the Insulin Receptor in Rat Brain

C. Agardh, Simeon I. Taylor, S. Taylor, 1984, Journal of neurochemistry.

pp-120: A common endogenous substrate for insulin and IGF-1 receptor-associated tyrosine kinase activity in the highly malignant AS-30D rat hepatoma cells

Simeon I. Taylor, A. Floridi, M. Fanciulli, 1989 .

Two mutant alleles of the insulin receptor gene in a family with a genetic form of insulin resistance: a 10 base pair deletion in exon 1 and a mutation substituting serine for asparagine-462

M. Quon, Simeon I. Taylor, T. Kadowaki, 1995, Human Genetics.

Insulin: still a miracle after all these years.

Simeon I. Taylor, F. Barbetti, 2019, The Journal of clinical investigation.

P-19: Dual role of a dileucine-centered motif in the control of insulin receptor internalization

Simeon I. Taylor, J. Carpentier, J. Paccaud, 2009 .

Erratum. Insulin Access and Affordability Working Group: Conclusions and Recommendations. Diabetes Care 2018;41;1299–1311

W. Herman, Simeon I. Taylor, W. Cefalu, 2018, Diabetes Care.

Genetic basis of endocrine disease. 1. Molecular genetics of insulin resistant diabetes mellitus.

D. Accili, Simeon I. Taylor, T. Kadowaki, 1991, The Journal of clinical endocrinology and metabolism.

Mutagenesis of lysine 460 in the human insulin receptor. Effects upon receptor recycling and cooperative interactions among binding sites.

Simeon I. Taylor, B. Marcus-Samuels, A. Rovira, 1990, The Journal of biological chemistry.

Five mutant alleles of the insulin receptor gene in patients with genetic forms of insulin resistance.

Simeon I. Taylor, T. Kadowaki, S. Taylor, 1990, The Journal of clinical investigation.

A mutation in the insulin receptor gene that impairs transport of the receptor to the plasma membrane and causes insulin‐resistant diabetes.

E. Lander, M. Permutt, A. Ullrich, 1989, The EMBO journal.

Two mutant alleles of the insulin receptor gene in a patient with extreme insulin resistance.

Simeon I. Taylor, B. Marcus-Samuels, T. Kadowaki, 1988, Science.

Point mutation causing a single amino acid substitution in the hormone binding domain of the glucocorticoid receptor in familial glucocorticoid resistance.

K. Constantine, D. Accili, G. Chrousos, 1991, The Journal of clinical investigation.

Deconstructing Type 2 Diabetes

Simeon I. Taylor, S. Taylor, S I Taylor, 1999, Cell.

A nonsense mutation causing decreased levels of insulin receptor mRNA: detection by a simplified technique for direct sequencing of genomic DNA amplified by the polymerase chain reaction.

Simeon I. Taylor, T. Kadowaki, S. Taylor, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Mutations in the insulin receptor gene in patients with genetic syndromes of insulin resistance and acanthosis nigricans.

D. Accili, Simeon I. Taylor, T. Kadowaki, 1992, The Journal of investigative dermatology.

A mutation in the tyrosine kinase domain of the insulin receptor associated with insulin resistance in an obese woman.

M. de la Luz Sierra, Simeon I. Taylor, L. Ottini, 1991, The Journal of clinical endocrinology and metabolism.

Mutations in the insulin receptor gene in patients with genetic syndromes of insulin resistance.

D. Accili, Simeon I. Taylor, T. Kadowaki, 1991, Advances in experimental medicine and biology.

A gene for congenital generalized lipodystrophy maps to human chromosome 9q34.

A. Bowcock, S. O’Rahilly, Simeon I. Taylor, 1999, The Journal of clinical endocrinology and metabolism.

Genetically defined forms of diabetes in children.

Simeon I. Taylor, S. Taylor, E. Arioglu, 1999, The Journal of clinical endocrinology and metabolism.

Insulin resistance due to mutations of the insulin receptor gene: An overview

D. Accili, Simeon I. Taylor, T. Kadowaki, 1992, Journal of endocrinological investigation.

Two mutations in a conserved structural motif in the insulin receptor inhibit normal folding and intracellular transport of the receptor.

Simeon I. Taylor, S. Taylor, E. Wertheimer, 1994, The Journal of biological chemistry.

Mutational and haplotype analyses of families with familial partial lipodystrophy (Dunnigan variety) reveal recurrent missense mutations in the globular C-terminal domain of lamin A/C.

M. Lovett, A. Bowcock, Simeon I. Taylor, 2000, American journal of human genetics.

Tissue distribution and subcellular localization of an endogenous substrate (pp 120) for the insulin receptor-associated tyrosine kinase.

D. Accili, Simeon I. Taylor, S. Taylor, 1986, Endocrinology.

Specific glycosylation site mutations of the insulin receptor alpha subunit impair intracellular transport.

Simeon I. Taylor, S. Taylor, J. Carpentier, 1993, Biochemistry.

Insulin-stimulated phosphorylation of recombinant pp120/HA4, an endogenous substrate of the insulin receptor tyrosine kinase.

D. Accili, Simeon I. Taylor, S. Taylor, 1995, Biochemistry.

Involvement of dileucine motifs in the internalization and degradation of the insulin receptor.

R. Klausner, C. Haft, Simeon I. Taylor, 1994, The Journal of biological chemistry.

pp120/ecto-ATPase, an endogenous substrate of the insulin receptor tyrosine kinase, is expressed as two variably spliced isoforms.

D. Accili, R. Margolis, Simeon I. Taylor, 1993, The Journal of biological chemistry.

Immunological Abnormalities in Insulin Receptors on Cultured EBV-Transformed Lymphocytes From Insulin-Resistant Patient With Leprechaunism

Simeon I. Taylor, A. Cama, B. Marcus‐Samuels, 1988, Diabetes.

Insulin-induced activation of a phosphatidyl inositol 3-kinase. Demonstration that the P85 subunit binds directly to the COOH terminus of the insulin receptor in intact cells

Simeon I. Taylor, S. Taylor, M. Taouis, 2022 .

Insulin-induced Activation of Phosphatidylinositol (PI) 3-Kinase

Simeon I. Taylor, R. Levy-Toledano, W. Larochelle, 1995, The Journal of Biological Chemistry.

Lipoatrophic-lipodystrophic syndromes: the spectrum of findings on MR imaging.

Simeon I. Taylor, S. Taylor, C. Chow, 2002, AJR. American journal of roentgenology.