H. Yokosawa

H. Yokosawa, T. Inagami, N. Yokosawa, 1980, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Production of monoclonal antibodies that inhibit ADP‐ribosylation of small GTP‐binding proteins catalyzed by Clostridium botulinum ADP‐ribosyltransferase C3

T. Katada, H. Yokosawa, S. Toratani, 1993, FEBS letters.

Inhibiting proteasome activity causes overreplication of DNA and blocks entry into mitosis in sea urchin embryos.

K. Tanaka, H. Yokosawa, R. Philipova, 2000, Journal of cell science.

Knocking out ubiquitin proteasome system function in vivo and in vitro with genetically encodable tandem ubiquitin.

H. Yokosawa, A. Toh-E, Y. Saeki, 2005, Methods in Enzymology.

Production and characterization of monoclonal antibodies specific to multi‐ubiquitin chains of polyubiquitinated proteins

M. Fujimuro, H. Yokosawa, H. Sawada, 1994, FEBS letters.

Highly polymorphic vitelline-coat protein HaVC80 from the ascidian, Halocynthia aurantium: structural analysis and involvement in self/nonself recognition during fertilization.

H. Yokosawa, Y. Harada, S. Ban, 2005, Developmental biology.

Differential display analysis reveals the expression of glutathione S-transferase ω and novel genes through an ITAM-containing receptor in ascidian immunocytes

H. Yokosawa, S. Yamasaki, Takashi Saito, 2005, Immunogenetics.

Self/nonself recognition in ascidian fertilization: vitelline coat protein HrVC70 is a candidate allorecognition molecule.

H. Yokosawa, S. Ban, Ken-ichi Matsumoto, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Tom1, a VHS Domain-containing Protein, Interacts with Tollip, Ubiquitin, and Clathrin*

H. Yokosawa, T. Yoshimori, M. Yamakami, 2003, Journal of Biological Chemistry.

Assembly of the 26S proteasome is regulated by phosphorylation of the p45/Rpt6 ATPase subunit.

H. Yokosawa, H. Sawada, H. Sasajima, 2001, Biochemistry.

Sodium dodecyl sulfate-induced conformational and enzymatic changes of multicatalytic proteinase.

H. Yokosawa, S. Ishii, Y. Saitoh, 1989, Biochemical and biophysical research communications.

Cell cycle-dependent change of proteasome distribution during embryonic development of the ascidian Halocynthia roretzi.

H. Yokosawa, H. Kawahara, 1992, Developmental biology.

Different ratios in 20 S proteasomes and regulatory subunit complexes in two isoforms of the 26 S proteasome purified from rabbit skeletal muscle

A. Goldberg, M. Fujimuro, H. Yokosawa, 1993, FEBS letters.

Intracellular calcium mobilization regulates the activity of 26 S proteasome during the metaphase-anaphase transition in the ascidian meiotic cell cycle.

H. Yokosawa, H. Kawahara, 1994, Developmental biology.

Activation of the proteasome during Xenopus egg activation implies a link between proteasome activation and intracellular calcium release.

K. Tanaka, H. Yokosawa, H. Kawahara, 1996, Biochemical and biophysical research communications.

Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme.

H. Yokosawa, Y. Saeki, Tomoharu Takeuchi, 2005, Journal of biochemistry.

Degradation of dynorphin-(1-13) and dynorphin-(1-17) by the neuroblastoma cell membrane. Evidence for the involvement of a cysteine protease.

H. Yokosawa, S. Ishii, M. Satoh, 1986, Biochemical and biophysical research communications.

The 26 S proteasome is activated at two points in the ascidian cell cycle

H. Yokosawa, H. Kawahara, H. Sawada, 1992, FEBS letters.

cDNA cloning and characterization of an osmotically sensitive TRP channel from ascidian eggs.

H. Yokosawa, M. Kashiwayanagi, M. Shimada, 2003, Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.

Evidence for an erbstatin-sensitive tyrosine kinase functioning in ascidian egg activation.

H. Yokosawa, K. Ueki, 1997, Biochemical and biophysical research communications.

Primary structure and function of superoxide dismutase from the ascidian Halocynthia roretzi.

H. Yokosawa, K. Azumi, H. Satoh, 1999, Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.

Targeting the proteasome pathway.

H. Yokosawa, S. Tsukamoto, 2009, Expert opinion on therapeutic targets.

Degradation of substance P by neuronal and glial cells cultured from rat fetal brain and their membranes

H. Yokosawa, S. Ishii, S. Endo, 1989, Neuropeptides.

Involvement of endopeptidase-24.11 in degradation of substance P by glioma cells

H. Yokosawa, S. Ishii, S. Endo, 1989, Neuropeptides.

Regulation of HTLV-1 Gag budding by Vps4A, Vps4B, and AIP1/Alix

H. Yokosawa, J. Yasuda, Shuzo Urata, 2007, Virology Journal.

Epidemiology of Epstein–Barr virus, cytomegalovirus, and kaposi's sarcoma‐associated herpesvirus infections in peripheral blood leukocytes revealed by a multiplex PCR assay

K. Nakashima, M. Fujimuro, H. Yokosawa, 2006, Journal of medical virology.

Human renal renin. Complete purification and characterization.

H. Yokosawa, T. Inagami, K. Murakami, 1980, The Journal of biological chemistry.

Involvement of angiotensin-converting enzyme (kininase II) in neuropeptide metabolism.

H. Yokosawa, S. Ishii, Y. Fujii, 1989, Advances in experimental medicine and biology.

Immunochemical identification of renin in rat brain and distinction from acid proteases

H. Yokosawa, T. Inagami, S. Hirose, 1978, Nature.

Involvement of metallo-endopeptidase in degradation of luteinizing hormone-releasing hormone by neuronal and glial cells cultured from rat fetal brain

H. Yokosawa, S. Ishii, C. Sakurada, 1991, Neuropeptides.

Proteasome Inhibitors Which Induce Neurite Outgrowth From PC12h Cells Cause Different Subcellular Accumulations of Multi-Ubiquitin Chains

H. Yokosawa, K. Hirata, M. Iigo, 1998, Neurochemical Research.

Multicopy Suppressors of ninl-l*

Y. Shimizu, M. Fujimuro, H. Yokosawa, 2003 .

The degradation of somatostatin by synaptic membrane of rat hippocampus is initiated by endopeptidase-24.11

H. Yokosawa, S. Ishii, C. Sakurada, 1990, Peptides.

Tom1 (target of Myb 1) is a novel negative regulator of interleukin-1- and tumor necrosis factor-induced signaling pathways.

H. Yokosawa, M. Yamakami, 2004, Biological & pharmaceutical bulletin.

Light-sensitive response in melanophores of Xenopus laevis: II.Rho is involved in light-induced melanin aggregation.

H. Yokosawa, Y. Miyashita, K. Asami, 1996, The Journal of experimental zoology.

Immuno‐crossreactivity between botulinum neurotoxin type C1 or D and exoenzyme C3

H. Yokosawa, K. Oguma, S. Ishii, 1989, FEBS letters.

Evidence for the involvement of the Rho GTP‐binding protein in egg activation of the ascidian Halocynthia roretzi

H. Yokosawa, S. Toratani, 1995, Development, growth & differentiation.

Himeic acid A: a new ubiquitin-activating enzyme inhibitor isolated from a marine-derived fungus, Aspergillus sp.

M. Fujimuro, H. Yokosawa, H. Onuki, 2005, Bioorganic & medicinal chemistry letters.

Purification and properties of N-acetylglucosaminidase from eggs of the ascidian, Halocynthia roretzi.

H. Yokosawa, H. Sawada, K. Matsuura, 1993, European journal of biochemistry.

Comparative studies on proteasomes (multicatalytic proteinases) isolated from spermatozoa and eggs of sea urchins.

H. Yokosawa, H. Kawahara, Y. Saitoh, 1991, Comparative biochemistry and physiology. B, Comparative biochemistry.

N-acetyl-galactosamine-specific lectin, a novel lectin in the haemolymph of the ascidian Halocynthia roretzi: isolation, characterization and comparison with galactose-specific lectin

H. Yokosawa, S. Ishii, Kaoru Harada-Azumi, 1987 .

ISG15 modification of Ubc13 suppresses its ubiquitin-conjugating activity.

H. Yokosawa, Tomoharu Takeuchi, 2005, Biochemical and biophysical research communications.

A new feature of angiotensin-converting enzyme in the brain: hydrolysis of substance P.

H. Yokosawa, S. Ishii, S. Endo, 1983, Biochemical and biophysical research communications.

Isolation and characterization of a novel 530-kDa protein complex (PC530) capable of associating with the 20S proteasome from starfish oocytes.

H. Yokosawa, E. Tanaka, C. Morinaga, 2000, Archives of biochemistry and biophysics.

Regulatory subunit complex dissociated from 26S proteasome: isolation and characterization.

H. Yokosawa, H. Sawada, T. Akaishi, 1995, Biochimica et biophysica acta.

Exogenous zinc ion is required for inhibitory activity of botulinum neurotoxin C1 against norepinephrine release and its endopeptidase activity toward substance P.

H. Yokosawa, K. Kimura, N. Fujii, 1994, Biochemistry and molecular biology international.

Lewy Bodies: Purification from Diffuse Lewy Body Disease Brains a

J. Trojanowski, V. Lee, T. Iwatsubo, 1996, Annals of the New York Academy of Sciences.

Cell-Cycle Dependent Dynamic Change of 26 S Proteasome Distribution in Tobacco BY-2 Cells

M. Fujimuro, H. Yokosawa, Keiji Tanaka, 2002 .

Acantholactam and pre-neo-kauluamine, manzamine-related alkaloids from the Indonesian marine sponge Acanthostrongylophora ingens.

H. Yokosawa, Yukio Fujiwara, M. Takeya, 2014, Journal of natural products.

Zymosan induces production of superoxide anions by hemocytes of the solitary ascidian Halocynthia roretzi.

H. Yokosawa, K. Azumi, S. Kanegasaki, 2002, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

Expression of trypsin-like proteases and protease nexin-1 in mdx mouse muscles.

H. Yokosawa, S. Ban, H. Sawada, 2004, Biochemical and biophysical research communications.

Therapeutic effect of camostat mesilate on Duchenne muscular dystrophy in mdx mice.

H. Yokosawa, S. Ban, H. Sawada, 2003, Biological & pharmaceutical bulletin.

Purification and Inhibition by Neuropeptides of Angiotensin‐Converting Enzyme from Rat Brain

H. Yokosawa, S. Ishii, Y. Ogura, 1983, Journal of neurochemistry.

Aggregation, Tyrosine Phosphorylation, and Gene Expression in Hemocytes of the Ascidian Halocynthia roretzi

H. Yokosawa, K. Azumi, 2001 .

Involvement of tyrosine kinase and phosphatidylinositol 3-kinase in phagocytosis by ascidian hemocytes.

H. Yokosawa, K. Azumi, G. Ishikawa, 2000, Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.

Cloning and Tyrosine Phosphorylation of a Novel Invertebrate Immunocyte Protein Containing Immunoreceptor Tyrosine-based Activation Motifs*

H. Yokosawa, K. Azumi, Hiroki Takahashi, 1997, The Journal of Biological Chemistry.

Cellular Factors Required for Lassa Virus Budding

T. Noda, Y. Kawaoka, H. Yokosawa, 2006, Journal of Virology.

Regulation of HTLV-1 Gag budding by Vps4A, Vps4B, and AIP1/Alix

H. Yokosawa, J. Yasuda, Shuzo Urata, 2007, Virology journal.

Identification and Herc5-mediated ISGylation of novel target proteins.

H. Yokosawa, S. Inoue, Tomoharu Takeuchi, 2006, Biochemical and biophysical research communications.

Purification of human renin.

H. Yokosawa, T. Inagami, E. Haas, 1978, Biochemical and biophysical research communications.

Isolation of salsolinol, a tetrahydroisoquinoline alkaloid, from the marine sponge Xestospongia cf. vansoesti as a proteasome inhibitor.

R. Ueoka, H. Yokosawa, H. Hirota, 2011, Chemical & pharmaceutical bulletin.

Dynorphin-degrading cysteine protease is highly specific for paired arginine residues

H. Yokosawa, S. Ishii, T. Watanabe, 1992, Experientia.

Identification, Characterization and Evidence for Intraneuronal Function of Renin in the Brain and Neuroblastoma Cells

H. Yokosawa, T. Inagami, D. Clemens, 1982 .

Renin and prorenin in hog brain: Ubiquitous distribution and high concentration in the pituitary and pineal

H. Yokosawa, T. Inagami, S. Hirose, 1980, Brain Research.

Regulates RANKL-Induced Osteoclastogenic Differentiation of RAW 264 Cells

H. Yokosawa, Tomoharu Takeuchi, M. Tamura, 2015 .

Characterization of Ascidian Plasma Growth Factors Promoting the Proliferation of Mouse Thymocytes

H. Yokosawa, K. Azumi, J. Iizuka, 1997 .

CDNA cloning of p112, the largest regulatory subunit of the human 26s proteasome, and functional analysis of its yeast homologue, sen3p.

T. Fujiwara, M. Yamasaki, Y. Shimizu, 1996, Molecular biology of the cell.

Hexylitaconic acid: a new inhibitor of p53-HDM2 interaction isolated from a marine-derived fungus, Arthrinium sp.

H. Yokosawa, S. Tsukamoto, T. Ohta, 2006, Bioorganic & medicinal chemistry letters.

Aaptamine, an alkaloid from the sponge Aaptos suberitoides, functions as a proteasome inhibitor.

H. Yokosawa, Kohei Sato, T. Ikeda, 2010, Bioorganic & medicinal chemistry letters.

Halenaquinone inhibits RANKL-induced osteoclastogenesis.

H. Yokosawa, S. Tsukamoto, N. D. de Voogd, 2014, Bioorganic & medicinal chemistry letters.

New polyhydroxy sterols: proteasome inhibitors from a marine sponge Acanthodendrilla sp.

H. Yokosawa, S. Tsukamoto, T. Ohta, 2003, Journal of natural products.

Inhibition of the Ubiquitin-Proteasome System by Natural Products for Cancer Therapy

H. Yokosawa, S. Tsukamoto, Sachiko Tsukamoto1, 2010, Planta medica.

Targeting the proteasome pathway

H. Yokosawa, S. Tsukamoto, 2009, Expert opinion on therapeutic targets.

Synthesis of 2,3- and 3,4-methanoamino acid equivalents with stereochemical diversity and their conversion into the tripeptide proteasome inhibitor belactosin a and its highly potent cis-cyclopropane stereoisomer.

S. Shuto, A. Matsuda, H. Yokosawa, 2008, Organic letters.

Guanine nucleotide‐binding protein in sea urchin eggs serving as the specific substrate of islet‐activating protein, pertussis toxin

T. Katada, H. Yokosawa, M. Ui, 1986, FEBS letters.

Ascidian phenoloxidase: its release from hemocytes, isolation, characterization and physiological roles.

H. Yokosawa, K. Azumi, S. Hata, 1998, Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.

A novel membrane glycoprotein involved in ascidian hemocyte aggregation and phagocytosis.

H. Yokosawa, K. Azumi, H. Takahashi, 1995, European journal of biochemistry.

Hemocyte aggregation in the solitary ascidian Halocynthia roretzi: plasma factors, magnesium ion, and Met-Lys-bradykinin induce the aggregation.

H. Yokosawa, K. Azumi, H. Takahashi, 1994, The Biological bulletin.

Functional and structural characterization of hemocytes of the solitary ascidian, Halocynthia roretzi

H. Yokosawa, N. Satoh, K. Azumi, 1993 .

A novel lipopolysaccharide-binding hemagglutinin isolated from hemocytes of the solitary ascidian, Halocynthia roretzi: it can agglutinate bacteria.

H. Yokosawa, K. Azumi, S. Ishii, 1991, Developmental and comparative immunology.

Halocyamines: novel antimicrobial tetrapeptide-like substances isolated from the hemocytes of the solitary ascidian Halocynthia roretzi.

H. Yokosawa, K. Azumi, S. Ishii, 1990, Biochemistry.

Thioltrypsin. Chemical transformation of the active-site serine residue of Streptomyces griseus trypsin to a cysteine residue.

H. Yokosawa, S. Ishii, S. Ojima, 1977, Journal of biochemistry.

Inhibitory effect of halocyamine, an antimicrobial substance from ascidian hemocytes, on the growth of fish viruses and marine bacteria

H. Yokosawa, M. Yoshimizu, K. Azumi, 1990, Experientia.

Opsonin-independent and -dependent Phagocytosis in the Ascidian Halocynthia roretzi: Galactose-specific Lectin and Complement C3 Function as Target-dependent Opsonins

H. Yokosawa, T. Fujita, M. Nonaka, 2000 .

A unique primary structure, cDNA cloning and function of a galactose-specific lectin from ascidian plasma.

H. Yokosawa, K. Azumi, Y. Abe, 1999, European journal of biochemistry.

Characterization of Novel Metallo-Proteases Released from Ascidian Hemocytes by Treatment with Calcium Ionophore

H. Yokosawa, K. Azumi, 1996, Zoological science.

Effects of plant lectins on cellular defense reactions of ascidian hemocytes

H. Yokosawa, K. Azumi, H. Takahashi, 1996, Experientia.

Characterization of Protease-Releasing Factors Isolated from Hemocytes of the Solitary Ascidian, Halocynthia roretzi

H. Yokosawa, K. Azumi, 1997 .

Lipopolysaccharide induces release of a metallo-protease from hemocytes of the ascidian, Halocynthia roretzi.

H. Yokosawa, K. Azumi, S. Ishii, 1991, Developmental and comparative immunology.

Galactose-specific lectin in the hemolymph of solitary ascidian, Halocynthia roretzi. Molecular, binding and functional properties.

H. Yokosawa, S. Ishii, K. Harada, 1986, Biochimica et biophysica acta.

Galactose-specific lectin in the hemolymph of solitary ascidian, Halocynthia roretzi : isolation and characterization.

H. Yokosawa, T. Numakunai, H. Sawada, 1982, Biochemical and biophysical research communications.

Primary structure of ascidian trypsin inhibitors in the hemolymph of a solitary ascidian, Halocynthia roretzi.

H. Yokosawa, S. Ishii, T. Kumazaki, 1990, Journal of Biochemistry (Tokyo).

cDNA Microarray Analyses Reveal Candidate Marker Genes for the Detection of Ascidian Disease in Korea

H. Yokosawa, K. Azumi, Yasufumi Miki, 2007, Zoological science.

Characterization of Cysteine Proteases Functioning in Degradation of Dynorphin in Neuroblastoma Cells: Evidence for the Presence of a Novel Enzyme with Strict Specificity Toward Paired Basic Residues

M. Satoh, H. Yokosawa, S. Ishii, 1989, Journal of neurochemistry.

Hyrtioreticulins A-E, indole alkaloids inhibiting the ubiquitin-activating enzyme, from the marine sponge Hyrtios reticulatus.

M. Fujimuro, H. Yokosawa, Y. Saeki, 2012, Bioorganic & medicinal chemistry.

Trypsin inhibitor in the hemolymph of a solitary ascidian, Halocynthia roretzi. Purification and characterization.

H. Yokosawa, S. Ishii, R. Odajima, 1985, Journal of biochemistry.

Asparaginyl endopeptidase of jack bean seeds. Purification, characterization, and high utility in protein sequence analysis.

H. Yokosawa, S. Ishii, M. Mitta, 1993, The Journal of biological chemistry.

Evidence for the participation of two sperm proteases, spermosin and acrosin, in fertilization of the ascidian, Halocynthia roretzi: inhibitory effects of leupeptin analogs on enzyme activities and fertilization.

H. Yokosawa, H. Sawada, S. Ishii, 1984, Developmental biology.

Isolation, characterization and cDNA cloning of a one-lobed transferrin from the ascidian Halocynthia roretzi.

H. Yokosawa, Y. Hasunuma, Y. Abe, 2001, Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.

Synthesis and structure of prolinal-containing peptides, and their use as specific inhibitors of prolyl endopeptidases.

H. Yokosawa, S. Ishii, M. Nishikata, 1986, Chemical & pharmaceutical bulletin.

N-Benzyloxycarbonyl-valyl-prolinal, a potent inhibitor of post-proline cleaving enzyme.

H. Yokosawa, S. Ishii, M. Nishikata, 1984, Journal of biochemistry.

Anhydrotrypsin: new features in ligand interactions revealed by affinity chromatography and thionine replacement.

H. Yokosawa, S. Ishii, 1977, Journal of biochemistry.

Affinity chromatography of trypsin and related enzymes. III. Purification of Streptomyces griseus trypsin using an affinity adsorbent containing a tryptic digest of protamine as a ligand.

H. Yokosawa, S. Ishii, T. Hanba, 1976, Journal of biochemistry.

Purification and characterization of two types of trypsin-like enzymes from sperm of the ascidian (Prochordata) Halocynthia roretzi. Evidence for the presence of spermosin, a novel acrosin-like enzyme.

H. Yokosawa, H. Sawada, S. Ishii, 1984, The Journal of biological chemistry.

Evidence for acrosin-like enzyme in sperm extract and its involvement in fertilization of the ascidian, Halocynthia roretzi

H. Yokosawa, M. Hoshi, H. Sawada, 1982 .

Ascidian sperm chymotrypsin-like enzyme; participation in fertilization

H. Yokosawa, M. Hoshi, H. Sawada, 1983, Experientia.

Extracellular ubiquitin system implicated in fertilization of the ascidian, Halocynthia roretzi: isolation and characterization.

H. Yokosawa, H. Sawada, N. Sakai, 2003, Developmental biology.

Timing of action of sperm proteases in ascidian fertilization

H. Yokosawa, T. Numakunai, H. Sawada, 2005, Experientia.

Localization and roles in fertilization of sperm proteasomes in the ascidian Halocynthia roretzi

H. Yokosawa, H. Sawada, Sandra Y. Flores, 2002, Molecular reproduction and development.

Extracellular ubiquitination and proteasome-mediated degradation of the ascidian sperm receptor

H. Yokosawa, S. Takizawa, E. Tanaka, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Spermosin, a trypsin-like protease from ascidian sperm: cDNA cloning, protein structures and functional analysis.

H. Yokosawa, T. Baba, H. Sawada, 2002, European journal of biochemistry.

Self-nonself Recognition and Lysin System in Fertilization of the Ascidian Halocynthia roretzi

H. Yokosawa, H. Sawada, 2001 .

Ascidian Sperm Acrosin and Spermosin: Structures and Roles in Fertilization

H. Yokosawa, T. Baba, H. Sawada, 2001 .

Physiological functions of proteasomes in ascidian fertilization and embryonic cell cycle.

Hideki Kawahara, H. Yokosawa, H. Sawada, 1996, Advances in experimental medicine and biology.

Effects of protease inhibitors on binding of sperm to the vitelline coat of ascidian eggs: implications for participation of a proteasome (multicatalytic proteinase complex).

H. Yokosawa, S. Takizawa, M. Hoshi, 1993, The Journal of experimental zoology.

Involvement of Rel/NF‐κB in regulation of ascidian notochord formation

H. Yokosawa, N. Satoh, M. Shimada, 2001, Development, growth & differentiation.

Title: Physical and functional interactions between STAT3 and Kaposi's Sarcoma-associated Herpesvirus-encoded LANA Running title: Physical and functional interactions between STAT3 and LANA Authors:

M. Fujimuro, H. Yokosawa, T. Matsuda, 2017 .

Molecular piracy: manipulation of the ubiquitin system by Kaposi's sarcoma‐associated herpesvirus

M. Fujimuro, H. Yokosawa, S. Hayward, 2007, Reviews in medical virology.

Apoptotic Effect of Ganciclovir on Primary Effusion Lymphoma Cells Infected with Kaposi's Sarcoma-Associated Herpesvirus

M. Fujimuro, H. Yokosawa, Y. Teishikata, 2006, Nucleosides, nucleotides & nucleic acids.

Regulation of NF-κB/Rel by IκB is essential for ascidian notochord formation

H. Yokosawa, H. Nishida, Hiroki Takahashi, 2005 .

Regulation of ascidian Rel by its alternative splice variant.

H. Yokosawa, N. Satoh, H. Kawahara, 2003, European journal of biochemistry.

Phorbol Ester Induces Elevation of the Vitelline Coat of Eggs of the Ascidian Halocynthia roretzi

H. Yokosawa, S. Ishii, S. Toratani, 1989, Development, growth & differentiation.

Rpn7 Is Required for the Structural Integrity of the 26 S Proteasome of Saccharomyces cerevisiae*

H. Yokosawa, Y. Saeki, E. Isono, 2004, Journal of Biological Chemistry.

Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome system.

H. Yokosawa, K. Nakagawa, H. Sasajima, 2002, European journal of biochemistry.

Degradation of transcription factor IRF-1 by the ubiquitin-proteasome pathway. The C-terminal region governs the protein stability.

H. Yokosawa, K. Nakagawa, 2000, European journal of biochemistry.

Isolation and characterization of a post-proline cleaving enzyme and its inhibitor from sperm of the ascidian, Halocynthia roretzi.

H. Yokosawa, H. Sawada, S. Ishii, 1983, Journal of biochemistry.

Inhibitory specificity change of the ovomucoid third domain of the silver pheasant upon introduction of an engineered Cys14-Cys39 bond.

T. Yamazaki, Y. Kyōgoku, H. Yokosawa, 2003, Biochemistry.

Serum concentrations of free ubiquitin and multiubiquitin chains.

M. Fujimuro, H. Yokosawa, H. Sawada, 1997, Clinical chemistry.

Lysine 63‐linked polyubiquitin chain may serve as a targeting signal for the 26S proteasome

Yasushi Saeki, H. Yokosawa, Y. Saeki, 2009, The EMBO journal.

Nob1p, a new essential protein, associates with the 26S proteasome of growing saccharomyces cerevisiae cells.

M. Fujimuro, K. Tanaka, H. Yokosawa, 2000, Gene.

The role of guanosine triphosphate hydrolysis in elongation factor Tu-promoted binding of aminoacyl transfer ribonucleic acid to ribosomes.

K. Arai, H. Yokosawa, Y. Kaziro, 1973, The Journal of biological chemistry.

Identification of ubiquitin-like protein-binding subunits of the 26S proteasome.

H. Yokosawa, Y. Saeki, T. Sone, 2002, Biochemical and biophysical research communications.

Ubiquitin-like proteins and Rpn10 play cooperative roles in ubiquitin-dependent proteolysis.

H. Yokosawa, Y. Saeki, A. Toh-e, 2002, Biochemical and biophysical research communications.

Rapid isolation and characterization of the yeast proteasome regulatory complex.

H. Yokosawa, Y. Saeki, A. Toh-e, 2000, Biochemical and biophysical research communications.

Girolline, an antitumor compound isolated from a sponge, induces G2/M cell cycle arrest and accumulation of polyubiquitinated p53.

H. Yokosawa, K. Yamashita, S. Matsunaga, 2004, Biological & pharmaceutical bulletin.

Transient activation of transgene expression by hydrodynamics-based injection may cause rapid decrease in plasmid DNA expression

M. Fujimuro, H. Yokosawa, H. Ochiai, 2007, Gene Therapy.

ISG15 regulates RANKL-induced osteoclastogenic differentiation of RAW264 cells.

H. Yokosawa, Tomoharu Takeuchi, M. Tamura, 2015, Biological & pharmaceutical bulletin.

Polyubiquitination of the B-cell translocation gene 1 and 2 proteins is promoted by the SCF ubiquitin ligase complex containing βTrCP.

H. Yokosawa, M. Kashiwayanagi, K. Nakagawa, 2012, Biological & pharmaceutical bulletin.

Definitive evidence for Ufd2-catalyzed elongation of the ubiquitin chain through Lys48 linkage.

H. Yokosawa, Y. Saeki, A. Toh-e, 2004, Biochemical and biophysical research communications.

Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin‐like domain

N. Hattori, S. Yokoyama, H. Yokosawa, 2003, EMBO reports.

Quantitative live-cell imaging reveals spatio-temporal dynamics and cytoplasmic assembly of the 26S proteasome

W. Baumeister, Y. Sako, H. Yokosawa, 2014, Nature Communications.

Cell-cycle dependent dynamic change of 26S proteasome distribution in tobacco BY-2 cells.

M. Fujimuro, H. Yokosawa, Keiji Tanaka, 2002, Plant & cell physiology.

Yeast counterparts of subunits S5a and p58 (S3) of the human 26S proteasome are encoded by two multicopy suppressors of nin1-1.

Y. Shimizu, C. Slaughter, M. Fujimuro, 1997, Molecular biology of the cell.

Nin1p, a regulatory subunit of the 26S proteasome, is necessary for activation of Cdc28p kinase of Saccharomyces cerevisiae.

Y. Shimizu, C. Slaughter, M. Fujimuro, 1995, The EMBO journal.

Sem1p Is a Novel Subunit of the 26 S Proteasome from Saccharomyces cerevisiae*

H. Yokosawa, Y. Saeki, T. Sone, 2004, Journal of Biological Chemistry.

Purification and characterization of trypsin-like enzyme from sea urchin eggs: substrate specificity and physiological role.

H. Yokosawa, H. Sawada, S. Ishii, 1984, Biochemical and biophysical research communications.

OMA‐1 is a P granules‐associated protein that is required for germline specification in Caenorhabditis elegans embryos

H. Yokosawa, H. Kawahara, M. Shimada, 2006, Genes to cells : devoted to molecular & cellular mechanisms.

Purification and characterization of Lewy bodies from the brains of patients with diffuse Lewy body disease.

J. Trojanowski, V. Lee, T. Iwatsubo, 1996, The American journal of pathology.

cDNA cloning and functional analysis of the p97 subunit of the 26S proteasome, a polypeptide identical to the type-1 tumor-necrosis-factor-receptor-associated protein-2/55.11.

K Tanaka, M. Yamasaki, Y. Shimizu, 1996, European journal of biochemistry.

Botulinum ADP-ribosyltransferase C3 induces elevation of the vitelline coat of ascidian eggs.

T. Katada, H. Yokosawa, S. Toratani, 1993, Biochemical and biophysical research communications.

Increasing the hydrolysis constant of the reactive site upon introduction of an engineered Cys14Cys39 bond into the ovomucoid third domain from silver pheasant

H. Yokosawa, K. Miura, Yuji Kobayashi, 2011, Journal of peptide science : an official publication of the European Peptide Society.

Isolation and analysis of cDNA encoding a precursor of Canavalia ensiformis asparaginyl endopeptidase (legumain).

H. Yokosawa, O. Takeda, S. Ishii, 1994, Journal of biochemistry.

Regulation of the Nuclear Factor (NF)-κB Pathway by ISGylation

H. Yokosawa, T. Sone, Tomoharu Takeuchi, 2008 .

Detection and analysis of protein ISGylation.

H. Yokosawa, Tomoharu Takeuchi, 2008, Methods in molecular biology.

Negative regulation of protein phosphatase 2Cβ by ISG15 conjugation

H. Yokosawa, S. Tamura, Takayasu Kobayashi, 2006, FEBS letters.

Intracellularly inducible, ubiquitin hydrolase-insensitive tandem ubiquitins inhibit the 26S proteasome activity and cell division.

H. Yokosawa, Y. Saeki, H. Kawahara, 2004, Genes & genetic systems.

Gastric GATA‐6 DNA‐binding protein: proteolysis induced by cAMP

H. Yokosawa, R. Nakagawa, R. Sato, 1997, FEBS letters.

Growth-dependent change of the 26S proteasome in budding yeast.

M. Fujimuro, H. Yokosawa, Y. Saeki, 1998, Biochemical and biophysical research communications.

Isolation of ubiquitin-E2 (ubiquitin-conjugating enzyme) complexes from erythroleukaemia cells using immunoaffinity techniques.

H. Taguchi, H. Yokosawa, Y. Okawa, 2001, The Biochemical journal.

Trypsin-like enzyme from eggs of the ascidian (protochordate), Halocynthia roretzi. Purification, properties, and physiological role.

H. Yokosawa, H. Sawada, S. Ishii, 1985, The Journal of biological chemistry.

Manadosterols A and B, sulfonated sterol dimers inhibiting the Ubc13-Uev1A interaction, isolated from the marine sponge Lissodendryx fibrosa.

H. Yokosawa, H. Morioka, S. Tsukamoto, 2012, Journal of natural products.

Localization and characterization of γ-glutamyl cyclotransferase in cancer cells.

H. Yokosawa, J. Hamada, K. Azumi, 2009, Molecular medicine reports.

Biochemical evidence for membrane-bound endoderm-specific alkaline phosphatase in larvae of the ascidian, Halocynthia roretzi.

H. Yokosawa, H. Nishida, G. Kumano, 1996, European journal of biochemistry.

Variabines A and B: new β-carboline alkaloids from the marine sponge Luffariella variabilis

H. Yokosawa, S. Tsukamoto, H. Rotinsulu, 2013, Journal of Natural Medicines.

N-Terminal modifications of the 19S regulatory particle subunits of the yeast proteasome.

H. Yokosawa, Y. Saeki, F. Sherman, 2003, Archives of biochemistry and biophysics.

Leucettamol A: a new inhibitor of Ubc13-Uev1A interaction isolated from a marine sponge, Leucetta aff. microrhaphis.

H. Yokosawa, S. Tsukamoto, T. Ohta, 2008, Bioorganic & medicinal chemistry letters.

The 26S Proteasome Rpn10 Gene Encoding Splicing Isoforms: Evolutional Conservation of the Genomic Organization in Vertebrates

H. Yokosawa, H. Kawahara, M. Shimada, 2002, Biological chemistry.

Regulation of the nuclear factor (NF)-kappaB pathway by ISGylation.

H. Yokosawa, T. Sone, Tomoharu Takeuchi, 2008, Biological & pharmaceutical bulletin.

The axonal transport of dipeptidyl aminopeptidase II, angiotensin-converting enzyme and other peptidases in rat sciatic nerves

H. Yokosawa, Akihiro Shimizu, Takeshi Kato, 1987, Neuroscience Research.

Siladenoserinols A-L: new sulfonated serinol derivatives from a tunicate as inhibitors of p53-Hdm2 interaction.

H. Yokosawa, H. Morioka, S. Tsukamoto, 2013, Organic letters.

Production of antipolyubiquitin monoclonal antibodies and their use for characterization and isolation of polyubiquitinated proteins.

M. Fujimuro, H. Yokosawa, 2005, Methods in enzymology.

Purification and characterization of multicatalytic proteinase from eggs of the ascidian Halocynthia roretzi.

H. Yokosawa, S. Ishii, Y. Saitoh, 1989, Journal of biochemistry.

Purification and characterization of hatching enzyme of Strongylocentrotus intermedius.

H. Yokosawa, M. Hoshi, K. Takeuchi, 1979, European journal of biochemistry.

Purification and characterization of a substance P-degrading endopeptidase from rat brain.

H. Yokosawa, S. Ishii, S. Endo, 1988, Journal of biochemistry.

Purification and characterization of the 26S proteasome from cultured rice (Oryza sativa) cells

Y. Murakami, H. Yokosawa, Y. Saeki, 1999 .

Purification and characterization of the 26 S proteasome from cultured rice ( Oryza sati 6 a ) cells

Y. Murakami, H. Yokosawa, Y. Saeki, 1999 .

Difference between PA700‐like proteasome activator complex and the regulatory complex dissociated from the 26S proteasome implies the involvement of modulating factors in the 26S proteasome assembly

H. Yokosawa, H. Sawada, T. Akaishi, 1997, FEBS letters.

Proteasomal ubiquitin receptor RPN-10 controls sex determination in Caenorhabditis elegans.

H. Yokosawa, Keiji Tanaka, H. Kawahara, 2006, Molecular biology of the cell.

High-molecular-weight protease complexes (proteasomes) of sperm of the ascidian, Halocynthia roretzi: isolation, characterization, and physiological roles in fertilization.

H. Yokosawa, H. Sawada, Y. Saitoh, 1993, Developmental biology.

Association of Rpn10 with high molecular weight complex is enhanced during retinoic acid-induced differentiation of neuroblastoma cells

H. Yokosawa, H. Kawahara, M. Shimada, 2007, Molecular and Cellular Biochemistry.

Acanthomanzamines A-E with new manzamine frameworks from the marine sponge Acanthostrongylophora ingens.

H. Yokosawa, Yukio Fujiwara, M. Takeya, 2014, Organic letters.

Natural products inhibiting the ubiquitin-proteasome proteolytic pathway, a target for drug development.

H. Yokosawa, S. Tsukamoto, 2006, Current medicinal chemistry.

Isolation and characterization of prolyl endopeptidase from eggs of the solitary ascidian Halocynthia roretzi: Comparison with the sperm enzyme

H. Yokosawa, J. Ito, S. Ishii, 1987 .

Nerve growth factor (NGF) induces increase in multi-ubiquitin chains and concomitant decrease in free ubiquitin in nuclei of PC 12h.

H. Yokosawa, K. Hirata, M. Iigo, 1996, Neuroscience Research.

Immunoassay for the quantification of intracellular multi-ubiquitin chains.

M. Fujimuro, H. Yokosawa, H. Sawada, 1995, European journal of biochemistry.

Transient nuclear factor kappaB (NF-kappaB) activation stimulated by interleukin-1beta may be partly dependent on proteasome activity, but not phosphorylation and ubiquitination of the IkappaBalpha molecule, in C6 glioma cells. Regulation of NF-kappaB linked to chemokine production.

M. Fujimuro, H. Yokosawa, T. Uehara, 1999, Journal of Biological Chemistry.

Hexylitaconic Acid: A New Inhibitor of p53—HDM2 Interaction Isolated from a Marine‐Derived Fungus, Arthrinium sp.

H. Yokosawa, S. Tsukamoto, T. Ohta, 2006 .

Immobilized anhydrotrypsin as a specific affinity adsorbent for tryptic peptides.

H. Yokosawa, S. Ishii, T. Kumazaki, 1983, Methods in enzymology.

Immobilized anhydrotrypsin as a biospecific affinity adsorbent for the peptides produced by trypsin-like proteases.

H. Yokosawa, S. Ishii, 1979, Analytical biochemistry.

The effective use of immobilized anhydrotrypsin for the isolation of biologically active peptides containing L-arginine residues in C-termini.

H. Yokosawa, S. Ishii, 1976, Biochemical and biophysical research communications.

Purification and fluorometric assay of proteinase A from yeast.

H. Yokosawa, S. Ishii, H. Ito, 1983, Analytical biochemistry.

Lewy Bodies: Purification from Diffuse Lewy Body Disease Brains a

J. Trojanowski, V. Lee, T. Iwatsubo, 1996, Annals of the New York Academy of Sciences.

Drug Development Targeting the Ubiquitin-Proteasome System

H. Yokosawa, S. Tsukamoto, 2011 .

Lysine 63‐linked polyubiquitin chain may serve as a targeting signal for the 26S proteasome

H. Yokosawa, Y. Saeki, Keiji Tanaka, 2009, The EMBO journal.

An Approach for the Identification of Proteins Modified with ISG15.

H. Yokosawa, Tomoharu Takeuchi, Y. Arata, 2019, Methods in molecular biology.