H. Brewer

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National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)

J. Mckenney, M. Proschan, S. Grundy, 2002 .

Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)

J. Mckenney, M. Weinstein, S. Grundy, 1993, JAMA.

Regulation of liver 3-hydroxy-3-methylglutaryl-CoA reductase.

H. Brewer, Z. Beg, 1981, Current topics in cellular regulation.

Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines.

S. Grundy, J. Cleeman, Sidney C. Smith, 2004, Arteriosclerosis, thrombosis, and vascular biology.

Triglyceride, high density lipoprotein, and coronary heart disease.

W. A. Bradley, D. Gordon, G. Hutchins, 1993, Consensus statement. National Institutes of Health Consensus Development Conference.

Tangier disease. High density lipoprotein deficiency due to defective metabolism of an abnormal apolipoprotein A-i (ApoA-ITangier).

H. Brewer, E. Schaefer, L. Kay, 1982, The Journal of clinical investigation.

Effect of exercise conditioning on plasma high density lipoproteins and other lipoproteins.

R. Bonow, H. Brewer, E. Schaefer, 1980, Atherosclerosis.

Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. The Expert Panel.

Daniel Steinberg, D. Roger Illingworth, Gustav Schonfeld, 1988, Archives of internal medicine.

Cardiovascular features of homozygous familial hypercholesterolemia: analysis of 16 patients.

B. McManus, W. Roberts, R. Gregg, 1984, The American journal of cardiology.

The heart in Tangier disease. Severe coronary atherosclerosis with near absence of high-density lipoprotein cholesterol.

D. Rader, W. Roberts, V. Ferrans, 1992, American journal of clinical pathology.

The familial hyperchylomicronemia syndrome. New insights into underlying genetic defects.

H. Brewer, S. Santamarina-Fojo, 1991, JAMA.

Changes in plasma cholesterol and triglyceride levels after treatment with oral isotretinoin. A prospective study.

H. Brewer, G. Peck, L. Zech, 1983, Archives of dermatology.

Human lipoprotein lipase: the loop covering the catalytic site is essential for interaction with lipid substrates.

H. Brewer, K. Dugi, S. Santamarina-Fojo, 1992, The Journal of biological chemistry.

Lipoprotein lipase: structure, function and mechanism of action

H. Brewer, S. Santamarina-Fojo, 1994, International journal of clinical & laboratory research.

Human lipoprotein lipase. Analysis of the catalytic triad by site-directed mutagenesis of Ser-132, Asp-156, and His-241.

H. Brewer, J. Brunzell, L. Previato, 1992, The Journal of biological chemistry.

Peroxisome proliferator-activated receptor beta/delta regulates very low density lipoprotein production and catabolism in mice on a Western diet.

H. Brewer, C. Nicol, J. Peters, 2004, The Journal of biological chemistry.

A pilot study of ex vivo gene therapy for homozygous familial hypercholesterolaemia

D. Rader, B. Clark, H. Brewer, 1995, Nature Medicine.

Complementary Roles of Farnesoid X Receptor, Pregnane X Receptor, and Constitutive Androstane Receptor in Protection against Bile Acid Toxicity*

S. Kliewer, J. Ward, H. Brewer, 2003, Journal of Biological Chemistry.

The chemical ionization mass spectrometric analysis of phenylthiohydantoin and 2-anilino-5-thiazolinone amino acids obtained from the Edman degradation of proteins and peptides.

H. Brewer, T. Fairwell, 1980, Analytical biochemistry.

Automated Edman degradations: studies with a large sequencer cup and high-speed drive.

H. Brewer, T. Fairwell, 1979, Analytical biochemistry.

An improved system for the separation and identification of phenylthiohydantoin derivatives of histidine and arginine by thin-layer chromatography.

H. Brewer, S. Bose, 1976, Analytical biochemistry.

Swine lipoproteins and atherosclerosis. Changes in the plasma lipoproteins and apoproteins induced by cholesterol feeding.

R. Mahley, G. Assmann, H. Brewer, 1975, Biochemistry.

2nd International Symposium on Triglycerides and HDL

H. Brewer, 2005 .

Cholesteryl Ester Transfer Protein Corrects Dysfunctional High Density Lipoproteins and Reduces Aortic Atherosclerosis in Lecithin Cholesterol Acyltransferase Transgenic Mice*

R. F. Hoyt, H. Brewer, R. Shamburek, 1999, The Journal of Biological Chemistry.

Lipoproteins as Biomarkers and Therapeutic Targets in the Setting of Acute Coronary Syndrome

D. Rader, H. Brewer, R. Rosenson, 2014, Circulation research.

Apolipoprotein B synthesis in humans: liver synthesizes only apolipoprotein B-100.

S. Edge, P. Schneider, H. Brewer, 1985, Metabolism: clinical and experimental.

The ABCA1 Transporter Modulates Late Endocytic Trafficking

H. Brewer, A. Remaley, C. Combs, 2004, Journal of Biological Chemistry.

In vivo protein metabolism utilizing stable isotopes and mass spectrometry: a new approach to the study of mutant proteins in humans.

D. Rader, R. Gregg, H. Brewer, 1990, Transactions of the Association of American Physicians.

Apolipoprotein E-4Philadelphia (Glu13----Lys,Arg145----Cys). Homozygosity for two rare point mutations in the apolipoprotein E gene combined with severe type III hyperlipoproteinemia.

H. Brewer, E. Stein, W. Mann, 1991, The Journal of biological chemistry.

In vivo metabolism of apolipoprotein A-I in a patient with homozygous familial hypercholesterolemia.

D. Rader, R. Gregg, H. Brewer, 1992, Arteriosclerosis and thrombosis : a journal of vascular biology.

Investigation of lipoprotein kinetics using endogenous labeling with stable isotopes

D. Rader, H. Brewer, J. Schaefer, 1992 .

HDL Infusion Therapy

H. Brewer, 2010 .

Clinical significance of high-density lipoproteins and the development of atherosclerosis: focus on the role of the adenosine triphosphate-binding cassette protein A1 transporter.

H. Brewer, S. Santamarina-Fojo, 2003, The American journal of cardiology.

A First-inMan , Randomized , Placebo-Controlled Study to Evaluate the Safety and Feasibility of Autologous Delipidated High-Density Lipoprotein Plasma Infusions in Patients With Acute Coronary Syndrome

P. Fitzgerald, N. Weissman, H. Brewer, 2022 .

HDL measures, particle heterogeneity, proposed nomenclature, and relation to atherosclerotic cardiovascular events.

R. Krauss, H. Brewer, E. Schaefer, 2011, Clinical chemistry.

Impact of low high-density lipoproteins on in-hospital events and one-year clinical outcomes in patients with non-ST-elevation myocardial infarction acute coronary syndrome treated with drug-eluting stent implantation.

H. Brewer, K. Kent, A. Pichard, 2006, The American journal of cardiology.

Translation of High-Density Lipoprotein Function Into Clinical Practice: Current Prospects and Future Challenges

P. Barter, A. Tall, H. Brewer, 2013, Circulation.

Hepatic ABCG5/G8 overexpression reduces apoB-lipoproteins and atherosclerosis when cholesterol absorption is inhibited Published, JLR Papers in Press, October 23, 2006.

B. Brewer, H. Brewer, R. Shamburek, 2007, Journal of Lipid Research.

Hepatic ABCG5 and ABCG8 Overexpression Increases Hepatobiliary Sterol Transport but Does Not Alter Aortic Atherosclerosis in Transgenic Mice*

G. Szakács, H. Brewer, R. Shamburek, 2004, Journal of Biological Chemistry.

Lipids, Apolipoproteins and Lipoproteins

D. Rader, H. Brewer, H. Brewer, 1994 .

Human liver apolipoprotein B-100 cDNA: complete nucleic acid and derived amino acid sequence.

H. Brewer, K. Lackner, K. Higuchi, 1986, Proceedings of the National Academy of Sciences of the United States of America.

In vivo metabolism of apolipoprotein A-IV in severe hypertriglyceridemia: a combined radiotracer and stable isotope kinetic study.

D. Rader, H. Brewer, P. Gambert, 1994, Journal of lipid research.

An approach to the management of hyperlipoproteinemia.

R. Gregg, H. Brewer, J. Hoeg, 1986, JAMA.

Effects of combination cholestyramine-neomycin treatment on plasma lipoprotein concentrations in type II hyperlipoproteinemia.

K. Bailey, R. Gregg, H. Brewer, 1985, The American journal of cardiology.

Normalization of plasma lipoprotein concentrations in patients with type II hyperlipoproteinemia by combined use of neomycin and niacin.

K. Bailey, R. Gregg, H. Brewer, 1984, Circulation.

The lipid-laden foam cell: an elusive target for therapeutic intervention.

H. Brewer, 2000, The Journal of clinical investigation.

Levels of lipoprotein Lp(a) decline with neomycin and niacin treatment.

H. Brewer, J. Hoeg, N. Papadopoulos, 1985, Atherosclerosis.

Cellular localization and trafficking of the human ABCA1 transporter.

H. Brewer, A. Remaley, S. Demosky, 2001 .

Apolipoprotein specificity for lipid efflux by the human ABCAI transporter.

H. Brewer, A. Remaley, T. Eggerman, 2001, Biochemical and biophysical research communications.

Hepatic CCAAT/enhancer binding protein alpha mediates induction of lipogenesis and regulation of glucose homeostasis in leptin-deficient mice.

Oksana Gavrilova, Yusuke Inoue, Derek LeRoith, 2004, Molecular endocrinology.

Identification of an apoC-II variant (apoC-IIBethesda) in a kindred with apoC-II deficiency and type I hyperlipoproteinemia.

R. Gregg, H. Brewer, D. Wilson, 1988, Journal of lipid research.

Purification and characterization of 3‐hydroxy‐3‐methylglutaryl coenzyme a reductase from chicken liver

H. Brewer, Z. Beg, J. Stonik, 1977, FEBS letters.

ABCA1 Overexpression in the Liver of LDLr-KO Mice Leads to Accumulation of Pro-atherogenic Lipoproteins and Enhanced Atherosclerosis*

H. Brewer, R. Shamburek, A. Remaley, 2006, Journal of Biological Chemistry.

Characterization of plasma lipids and lipoproteins in patients with beta 2-glycoprotein I (apolipoprotein H) deficiency.

R. Gregg, H. Brewer, J. Hoeg, 1985, Atherosclerosis.

Presence of two forms of apolipoprotein B in patients with dyslipoproteinemia.

R. Gregg, H. Brewer, E. Schaefer, 1983, Journal of lipid research.

Identification of low density lipoprotein receptor binding domains of human apolipoprotein B-100: a proposed consensus LDL receptor binding sequence of apoB-100.

H. Brewer, K. Lackner, A. Hospattankar, 1986, Biochemical and biophysical research communications.

Apolipoproteins and lipoproteins in human plasma: an overview.

R. Gregg, H. Brewer, J. Hoeg, 1988, Clinical chemistry.

High plasma HDL concentrations associated with enhanced atherosclerosis in transgenic mice overexpressing lecithinchoesteryl acyltransferase

R. F. Hoyt, H. Brewer, R. Shamburek, 1997, Nature Medicine.

Activation of human post heparin lipoprotein lipase by apolipoprotein H (beta 2-glycoprotein I).

H. Brewer, E. Schaefer, Y. Nakaya, 1980, Biochemical and biophysical research communications.

Prospects and Future Challenges Translation of High-Density Lipoprotein Function Into Clinical Practice: Current

P. Barter, A. Tall, H. Brewer, 2013 .

Evacetrapib alone or in combination with statins lowers lipoprotein(a) and total and small LDL particle concentrations in mildly hypercholesterolemic patients.

H. Brewer, S. Nissen, K. Krueger, 2016, Journal of clinical lipidology.

DextranSulfate-Mg2 Precipitation Procedure forQuantitation of High- Density-Lipoprotein Cholesterol

H. Brewer, E. Schaefer, G. Cooper, 1982 .

Effect of the BET Protein Inhibitor, RVX-208, on Progression of Coronary Atherosclerosis: Results of the Phase 2b, Randomized, Double-Blind, Multicenter, ASSURE Trial

P. Barter, J. Kastelein, C. Ballantyne, 2016, American Journal of Cardiovascular Drugs.

ApoA-I Induction as a Potential Cardioprotective Strategy: Rationale for the SUSTAIN and ASSURE Studies

P. Barter, J. Kastelein, C. Ballantyne, 2012, Cardiovascular Drugs and Therapy.

Adenoviral expression of human lecithin-cholesterol acyltransferase in nonhuman primates leads to an antiatherogenic lipoprotein phenotype by increasing high-density lipoprotein and lowering low-density lipoprotein.

R. F. Hoyt, H. Brewer, R. Shamburek, 2009, Metabolism: clinical and experimental.

The composition and metabolism of high density lipoprotein subfractions

H. Brewer, E. Schaefer, R. Levy, 1979, Lipids.

Current concepts of the molecular structure and metabolism of human apolipoproteins and lipoproteins

H. Brewer, 1981, Klinische Wochenschrift.

Only in the Presence of Normal LDL Receptors in Transgenic Rabbits LCAT Modulates Atherogenic Plasma Lipoproteins and the Extent of Atherosclerosis

H. Brewer, J. Hoeg, E. Herderick, 2000 .

LCAT modulates atherogenic plasma lipoproteins and the extent of atherosclerosis only in the presence of normal LDL receptors in transgenic rabbits.

H. Brewer, J. Hoeg, E. Herderick, 2000, Arteriosclerosis, thrombosis, and vascular biology.

Upregulated synthesis of both apolipoprotein A-I and apolipoprotein B in familial hyperalphalipoproteinemia and hyperbetalipoproteinemia.

M. Manns, R. Gregg, H. Brewer, 1998, Metabolism: clinical and experimental.

Correction of hypoalphalipoproteinemia in LDL receptor-deficient rabbits by lecithin:cholesterol acyltransferase.

H. Brewer, J. Hoeg, J. Wang, 1998, Journal of lipid research.

Adenoviral delivery of low-density lipoprotein receptors to hyperlipidemic rabbits: receptor expression modulates high-density lipoproteins.

H. Brewer, J. Hoeg, R. Shamburek, 1996, Metabolism: clinical and experimental.

Familial HDL deficiency due to marked hypercatabolism of normal apoA-I.

D. Rader, H. Brewer, B. Vergès, 1993, Arteriosclerosis and thrombosis : a journal of vascular biology.

The Molecular Basis of Genetic Defects in HDL Metabolism

D. Rader, H. Klein, H. Brewer, 1993 .

Impaired in vivo metabolism of HDL in familial hypercholesterolemia

D. Rader, H. Brewer, L. Zech, 1993 .

Recent advances in lipoprotein metabolism and the genetic dyslipoproteinemias.

D. Rader, H. Brewer, J. Hoeg, 1991, Advances in experimental medicine and biology.

Apolipoprotein A-I metabolism in subjects with a PstI restriction fragment length polymorphism of the apoA-I gene and familial hypoalphalipoproteinemia.

R. Gregg, H. Brewer, C. Glueck, 1990, Journal of lipid research.

In Vivo Catabolism of Apolipoprotein A-I in Subjects with Familial Hypoalphalipoproteinemia

G. Franceschini, C. Sirtori, R. Gregg, 1989 .

Estimation of VLDL cholesterol in hyperlipidemia.

P. Wilson, R. Gregg, H. Brewer, 1985, Clinica chimica acta; international journal of clinical chemistry.

Risk factors for the development of premature cardiovascular disease.

R. Gregg, H. Brewer, J. Hoeg, 1985, Advances in experimental medicine and biology.

Kinetics of apolipoproteins A-I and A-II

H. Brewer, E. Schaefer, J. C. Osborne, 1984 .

Type III Hyperlipoproteinemia: Diagnosis, Molecular Defects, Pathology, and Treatment

R. Gregg, H. Brewer, E. Schaefer, 1983 .

PLASMA-TRIGLYCERIDES IN REGULATION OF H.D.L.-CHOLESTEROL LEVELS

W. Blackwelder, H. Brewer, E. Schaefer, 1978, The Lancet.

Mevinolin and Neomycin in the Treatment of Type II Hyperlipoproteinemia

K. Bailey, H. Brewer, J. Hoeg, 1987 .

The effects of mevinolin and neomycin alone and in combination on plasma lipid and lipoprotein concentrations in type II hyperlipoproteinemia.

K. Bailey, H. Brewer, J. Hoeg, 1986, Atherosclerosis.

Distribution of subclasses of HDL containing apoA-I without apoA-II (LpA-I) in normolipidemic men and women.

H. Brewer, D. Rader, N. Duverger, 1994, Arteriosclerosis and thrombosis : a journal of vascular biology.

Clinical significance of plasma lipid levels.

H. Brewer, 1989, The American journal of cardiology.

Decreased plasma levels of lipoprotein(a) in patients with hypertriglyceridemia.

D. Rader, H. Brewer, G. Talley, 1994, Atherosclerosis.

Correlation of apolipoprotein(a) isoproteins with Lp(a) density and distribution in fasting plasma.

D. Rader, H. Brewer, U. Beisiegel, 1992, Atherosclerosis.

The effects of low cholesterol, high polyunsaturated fat, and low fat diets on plasma lipid and lipoprotein cholesterol levels in normal and hypercholesterolemic subjects.

H. Brewer, N. Ernst, E. Schaefer, 1981, The American journal of clinical nutrition.

Effect of low density lipoproteins, high density lipoproteins, and cholesterol on apolipoprotein A‐I mRNA in Hep G2 cells

H. Brewer, J. Hoeg, J. Monge, 1989, FEBS letters.

The impact of proprotein convertase subtilisin-kexin type 9 serine protease inhibitors on lipid levels and outcomes in patients with primary hypercholesterolaemia: a network meta-analysis.

H. Brewer, R. Torguson, R. Waksman, 2016, European heart journal.

Type III hyperlipoproteinemia: defective metabolism of an abnormal apolipoprotein E.

R. Gregg, H. Brewer, E. Schaefer, 1981, Science.

In vivo metabolism of a mutant apolipoprotein, apoA-IIowa, associated with hypoalphalipoproteinemia and hereditary systemic amyloidosis.

D. Rader, R. Gregg, H. Brewer, 1992, Journal of lipid research.

Human proapolipoprotein A-I: development of an antibody to the propeptide as a probe of apolipoprotein A-I biosynthesis and processing.

E. Appella, H. Brewer, A. Hospattankar, 1987, Biochemical and biophysical research communications.

The molecular biology of human apoA-I, apoA-II, apoC-II and apoB.

H. Brewer, K. Lackner, J. Monge, 1986, Advances in experimental medicine and biology.

Isolation and characterization of apolipoproteins A-I, A-II, and A-IV.

H. Brewer, H. Bryan Brewer, R. Ronan, 1986, Methods in enzymology.

cDNA cloning of human apoA-I: amino acid sequence of preproapoA-I.

H. Brewer, S. Law, Glenn N. Gray, 1983, Biochemical and biophysical research communications.

Human apolipoprotein A-l and A4 metabolism

H. Brewer, E. Schaefer, R. Aamodt, 1982 .

Coronary heart disease prevalence and other clinical features in familial high-density lipoprotein deficiency (Tangier disease).

H. Brewer, E. Schaefer, L. Zech, 1980, Annals of internal medicine.

Metabolism of high-density lipoprotein apolipoproteins in Tangier disease.

C. Blum, H. Brewer, E. Schaefer, 1978, The New England journal of medicine.

Definition of Metabolic Syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association Conference on Scientific Issues Related to Definition

S. Grundy, J. Cleeman, Sidney C. Smith, 2004, Arteriosclerosis, Thrombosis and Vascular Biology.

Increased production of apolipoprotein A-I associated with elevated plasma levels of high-density lipoproteins, apolipoprotein A-I, and lipoprotein A-I in a patient with familial hyperalphalipoproteinemia.

D. Rader, H. Brewer, L. Zech, 1993, Metabolism: clinical and experimental.

The ABCA1 transporter functions on the basolateral surface of hepatocytes.

H. Brewer, A. Remaley, C. Combs, 2002, Biochemical and biophysical research communications.

Regulation and intracellular trafficking of the ABCA1 transporter.

H. Brewer, A. Remaley, S. Santamarina-Fojo, 2001, Journal of lipid research.

Assessment of the clinical effects of cholesteryl ester transfer protein inhibition with evacetrapib in patients at high-risk for vascular outcomes: Rationale and design of the ACCELERATE trial.

D. Rader, P. Barter, A. Tall, 2015, American heart journal.

Variation in lipoprotein(a) concentrations among individuals with the same apolipoprotein (a) isoform is determined by the rate of lipoprotein(a) production.

D. Rader, H. Brewer, A. Zech, 1993, The Journal of clinical investigation.

Genetic (primary) forms of hypertriglyceridemia.

G. Assmann, H. Brewer, Brewer Hb, 1991, The American journal of cardiology.

Lipoprotein lipase correlates positively and hepatic lipase inversely with calcific atherosclerosis in homozygous familial hypercholesterolemia.

H. Brewer, K. Dugi, I. Feuerstein, 1997, Arteriosclerosis, thrombosis, and vascular biology.

Tissue-specific expression of apolipoprotein A-I (ApoA-I) is regulated by the 5'-flanking region of the human ApoA-I gene.

H. Brewer, J. Hoeg, K. Higuchi, 1988, The Journal of biological chemistry.

Hypercholesterolemia, Hypocholesterolemia, Hypertriglyceridemia, in Vivo Kinetics

H. Brewer, P. Alaupovic, C. Malmendier, 1991, Advances in Experimental Medicine and Biology.

Identification of two separate allelic mutations in the lipoprotein lipase gene of a patient with the familial hyperchylomicronemia syndrome.

H. Brewer, J. Brunzell, S. Skarlatos, 1991, The Journal of biological chemistry.

Cubilin, the endocytic receptor for intrinsic factor-vitamin B(12) complex, mediates high-density lipoprotein holoparticle endocytosis.

H. Brewer, A. Remaley, S. Stefansson, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Cholesterol Efflux Capacity and Pre-Beta-1 HDL Concentrations Are Increased in Dyslipidemic Patients Treated With Evacetrapib.

D. Rader, H. Brewer, S. Nissen, 2015, Journal of the American College of Cardiology.

Cholesterol ester transfer protein inhibition by TA-8995 in patients with mild dyslipidaemia (TULIP): a randomised, double-blind, placebo-controlled phase 2 trial

D. Rader, P. Barter, J. Kastelein, 2015, The Lancet.

Human apolipoprotein A-I. Post-translational modification by fatty acid acylation.

H. Brewer, J. Hoeg, R. Ronan, 1986, The Journal of biological chemistry.

Implications of Recent Clinical Trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines

Neil J Stone, S. Grundy, J. Cleeman, 2004, Circulation.

The Evolving Role of HDL in the Treatment of High-Risk Patients with Cardiovascular Disease

H. Brewer, 2011 .

Distinct hepatic receptors for low density lipoprotein and apolipoprotein E in humans.

R. Gregg, H. Brewer, E. Schaefer, 1985, Science.

Familial apolipoprotein E deficiency.

J. Ordovás, R. Gregg, H. Brewer, 1986, The Journal of clinical investigation.

Low-Density Lipoprotein Receptor and Apolipoprotein A-I and B Expression in Human Enterocytes

D. Sviridov, H. Brewer, J. Hoeg, 2003, Digestion.

Targeted Disruption of the Mouse Lecithin:Cholesterol Acyltransferase (LCAT) Gene

R. F. Hoyt, H. Brewer, C. Koch, 1997, The Journal of Biological Chemistry.

Biochemical characterization of the three major subclasses of lipoprotein A-I preparatively isolated from human plasma.

P. Duchateau, D. Rader, H. Brewer, 1993, Biochemistry.

Tangier disease: isolation and characterization of LpA-I, LpA-II, LpA-I: A-II and LpA-IV particles from plasma.

P. Duchateau, D. Rader, H. Brewer, 1993, Biochimica et biophysica acta.

Two-dimensional electrophoresis of human plasma apolipoproteins.

H. Brewer, D. Sprecher, L. Taam, 1984, Clinical chemistry.

The orphan nuclear receptor LRH-1 activates the ABCG5/ABCG8 intergenic promoter

H. Brewer, A. Remaley, A. Kennedy, 2004 .

Tangier disease : A structural defect in apolipoprotein A-I ( apoA-ITangir ) ( apolipoprotein A-1 H / dyslipoproteinemia / atherosclerosis / high density lipoproteins / cholesterol )

H. Brewer, E. Schaefer, L. Kay, 2003 .

Hyperalphalipoproteinemia in human lecithin cholesterol acyltransferase transgenic rabbits. In vivo apolipoprotein A-I catabolism is delayed in a gene dose-dependent manner.

H. Brewer, J. Hoeg, A. Bérard, 1996, The Journal of clinical investigation.

Adenovirus-mediated expression of hepatic lipase in LCAT transgenic mice.

H. Brewer, K. Dugi, N. Sakai, 1997, Journal of lipid research.

Regulation of plasma high-density lipoprotein levels by the ABCA1 transporter and the emerging role of high-density lipoprotein in the treatment of cardiovascular disease.

B. Brewer, H. Brewer, A. Remaley, 2004, Arteriosclerosis, thrombosis, and vascular biology.

Characterization of high-density apolipoprotein particles A-I and A-I:A-II isolated from humans with cholesteryl ester transfer protein deficiency.

D. Rader, H. Brewer, T. Ishikawa, 1995, European journal of biochemistry.

VLDL ApoB-100 and ApoE Metabolism in Male and Female Subjects Utilizing the Stable Isotope Technique

D. Rader, R. Gregg, H. Brewer, 1993 .

Overexpression of human lecithin:cholesterol acyltransferase in cholesterol-fed rabbits: LDL metabolism and HDL metabolism are affected in a gene dose-dependent manner.

H. Brewer, J. Hoeg, A. Bérard, 1997, Journal of lipid research.

Human apolipoprotein A-I isoprotein metabolism: proapoA-I conversion to mature apoA-I.

R. Gregg, H. Brewer, E. Schaefer, 1985, Journal of lipid research.

Lipoprotein abnormalities in primary biliary cirrhosis. Association with hepatic lipase inhibition as well as altered cholesterol esterification.

J. Hoofnagle, H. Brewer, E. Schaefer, 1985, Gastroenterology.

Hypertriglyceridaemia due to genetic defects in lipoprotein lipase and apolipoprotein C‐II

H. Brewer, S. Fojo, 1992, Journal of internal medicine.

NEW INsIGHTS INTO THE ROLE OF HDL IN THE DEVELOPMENT OF CARDIOVASCULAR

H. Brewer, 1998 .

Apolipoprotein E metabolism in normolipoproteinemic human subjects.

R. Gregg, H. Brewer, E. Schaefer, 1984, Journal of lipid research.

Human apolipoprotein B (apoB) mRNA: identification of two distinct apoB mRNAs, an mRNA with the apoB-100 sequence and an apoB mRNA containing a premature in-frame translational stop codon, in both liver and intestine.

H. Brewer, J. Cortright, K. Higuchi, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Human chylomicron apolipoprotein metabolism.

H. Brewer, E. Schaefer, L. L. Jenkins, 1978, Biochemical and biophysical research communications.

Plasma apolipoprotein A-1 absence associated with a marked reduction of high density lipoproteins and premature coronary artery disease.

W. H. Heaton, H. Brewer, E. Schaefer, 1982, Arteriosclerosis.

Vitamin E dose-response studies in humans with use of deuterated RRR-alpha-tocopherol.

D. Rader, H. Brewer, M. Traber, 1998, The American journal of clinical nutrition.

Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells Published, JLR Papers in Press, March 1, 2005. DOI 10.1194/jlr.M400396-JLR200

N. Seidah, M. Krempf, H. Brewer, 2005, Journal of Lipid Research.

The inverse association of plasma lipoprotein(a) concentrations with apolipoprotein(a) isoform size is not due to differences in Lp(a) catabolism but to differences in production rate.

D. Rader, H. Brewer, L. Zech, 1994, The Journal of clinical investigation.

The effects of estrogen administration on plasma lipoprotein metabolism in premenopausal females.

H. Brewer, E. Schaefer, R. Levy, 1983, The Journal of clinical endocrinology and metabolism.

Lipoprotein(a). Clinical approach to a unique atherogenic lipoprotein.

D. Rader, H. Brewer, 1992, JAMA.

Meeting Summary Workshop on Apolipoprotein Quantification

H. Brewer, A. Gotto, H. Tyroler, 2005 .

Plasma Phospholipid Transfer Protein

H. Brewer, R. Shamburek, B. Föger, 1997, The Journal of Biological Chemistry.

Hepatic lipase gene therapy in hepatic lipase-deficient mice. Adenovirus-mediated replacement of a lipolytic enzyme to the vascular endothelium.

H. Brewer, R. Shamburek, N. Maeda, 1996, The Journal of clinical investigation.

Comparative evaluation of fibric acid derivatives and HMG-CoA reductase inhibitors

H. Brewer, 1992 .

Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines.

S. Grundy, J. Cleeman, Sidney C. Smith, 2004, Journal of the American College of Cardiology.

Apolipoprotein A-I isoforms in human lymph: effect of fat absorption.

H. Brewer, E. Schaefer, G. Ghiselli, 1983, Journal of lipid research.

Amino acid sequence of human apoLp-Gln-II (apoA-II), an apolipoprotein isolated from the high-density lipoprotein complex.

H. Brewer, K. John, S. Lux, 1972, Proceedings of the National Academy of Sciences of the United States of America.

A molecular model of high density lipoproteins.

G. Assmann, H. Brewer, 1974, Proceedings of the National Academy of Sciences of the United States of America.

Human proapoA-ITangier: isolation of proapoA-ITangier and amino acid sequence of the propeptide.

H. Brewer, L. Kay, R. Ronan, 1983, Biochemical and biophysical research communications.

Transport of apolipoproteins A-I and A-II by human thoracic duct lymph.

T. Starzl, H. Brewer, E. Schaefer, 1981, The Journal of clinical investigation.

Human plasma proapoA-I: isolation and amino-terminal sequence.

H. Brewer, L. Kay, R. Ronan, 1983, Biochemical and biophysical research communications.

Activation of the enzymic activity of hepatic lipase by apolipoprotein A-II. Characterization of a major component of high density lipoprotein as the activating plasma component in vitro.

H. Brewer, E. Schaefer, J. C. Osborne, 1983, European journal of biochemistry.

CETP , Lipoprotein Metabolism , and Atherosclerosis in Humans Genetic CETP Deficiency in Humans and Effects on Lipoprotein Metabolism

D. Rader, C. Hennekens, P. Barter, 2003 .

Role of CETP in the Development of Atherosclerosis in Animals Expression of CETP in Transgenic Mice

D. Rader, C. Hennekens, P. Barter, 2003 .

In vivo metabolism of apolipoprotein E within the HDL subpopulations LpE, LpE:A-I, LpE:A-II and LpE:A-I:A-II.

H. Brewer, R. Shamburek, P. Alaupovic, 2002, Atherosclerosis.

Effect of thyrocalcitonin on adenosine 3':5'-cyclic phosphate formation by rat kidney and bone.

F. Murad, H. Brewer, M. Vaughan, 1970, Proceedings of the National Academy of Sciences of the United States of America.

In vivo metabolism of apolipoproteins A-I and E in patients with abetalipoproteinemia: implications for the roles of apolipoproteins B and E in HDL metabolism.

D. Rader, H. Brewer, L. Zech, 1994, Journal of lipid research.

Human Lecithin:Cholesterol Acyltransferase Deficiency: In Vivo Kinetics of Low-Density Lipoprotein and Lipoprotein-X

H. Brewer, R. Shamburek, A. Remaley, 2006, Arteriosclerosis, thrombosis, and vascular biology.

The Mutations of Apolipoprotein B Gene Causing Hypobetalipoproteinemia: Molecular and Functional Abnormalities in Apo B-87Padova

H. Brewer, G. Crepaldi, C. Gabelli, 1993 .

Separation of apolipoprotein B species by agarose-acrylamide gel electrophoresis.

R. Gregg, H. Brewer, C. Gabelli, 1986, Journal of lipid research.

Abnormal low density lipoprotein metabolism in apolipoprotein E deficiency.

R. Gregg, H. Brewer, E. Manzato, 1986, Journal of lipid research.

Transfer of human lymph chylomicron constituents to other lipoprotein density fractions during in vitro lipolysis.

H. Brewer, E. Schaefer, T. Olivecrona, 1982, Journal of lipid research.

Focus on high-density lipoproteins in reducing cardiovascular risk.

H. Brewer, 2004, American heart journal.

Analysis of Glomerulosclerosis and Atherosclerosis in Lecithin Cholesterol Acyltransferase-deficient Mice*

J. Brady, G. Striker, H. Brewer, 2001, The Journal of Biological Chemistry.

ApoA-II kinetics in humans using endogenous labeling with stable isotopes: slower turnover of apoA-II compared with the exogenous radiotracer method.

D. Rader, H. Brewer, L. Zech, 1996, Journal of lipid research.

Role of Gene Therapy in the Treatment of the Genetic Dyslipoproteinemias

H. Brewer, J. Hoeg, S. Santamarina-Fojo, 1996 .

Apolipoprotein A-II production rate is a major factor regulating the distribution of apolipoprotein A-I among HDL subclasses LpA-I and LpA-I:A-II in normolipidemic humans.

D. Rader, H. Brewer, L. Zech, 1995, Arteriosclerosis, thrombosis, and vascular biology.

Chapter 15 – Effectiveness of Diet and Drugs in the Treatment of Patients with Elevated Lp(a) Levels

H. Brewer, 1990 .

Delayed low density lipoprotein (LDL) catabolism despite a functional intact LDL-apolipoprotein B particle and LDL-receptor in a subject with clinical homozygous familial hypercholesterolemia.

H. Brewer, R. Shamburek, H. H. Schmidt, 1998, The Journal of clinical endocrinology and metabolism.

Dominant expression of type III hyperlipoproteinemia. Pathophysiological insights derived from the structural and kinetic characteristics of ApoE-1 (Lys146-->Glu).

R. Gregg, H. Brewer, J. Hoeg, 1995, The Journal of clinical investigation.

Analysis of the mixed association between human apolipoproteins A-I and A-II in aqueous solution.

H. Brewer, J. C. Osborne, G. M. Powell, 1980, Biochimica et biophysica acta.

Advances in the gas chromatographic analysis of amino acid phenyl- and methylthiohydantoins.

H. Brewer, T. J. Bronzert, J. Pisano, 1972, Analytical biochemistry.

Decreased reverse cholesterol transport from Tangier disease fibroblasts. Acceptor specificity and effect of brefeldin on lipid efflux.

H. Brewer, A. Remaley, U. Schumacher, 1997, Arteriosclerosis, thrombosis, and vascular biology.

Asymmetry in the Lipid Affinity of Bihelical Amphipathic Peptides

D. Sviridov, H. Brewer, A. Remaley, 2008, Journal of Biological Chemistry.

Massive omental reticuloendothelial cell lipid uptake in Tangier disease after splenectomy.

T. Triche, L. Stein, H. Brewer, 1983, The American journal of medicine.

Tangier disease. The complete mRNA sequence encoding for preproapo-A-I.

H. Brewer, S. Law, 1985, The Journal of biological chemistry.

Analysis of the apolipoprotein B gene and messenger ribonucleic acid in abetalipoproteinemia.

T. Triche, R. Gregg, H. Brewer, 1986, The Journal of clinical investigation.

Hepatic lipase deficiency decreases the selective uptake of HDL-cholesteryl esters in vivo.

H. Brewer, R. Shamburek, B. Föger, 2000, Journal of lipid research.

Hepatic lipase facilitates the selective uptake of cholesteryl esters from remnant lipoproteins in apoE-deficient mice.

R. F. Hoyt, H. Brewer, R. Shamburek, 1998, Journal of lipid research.

Characterization of high density lipoprotein-bound and soluble RT6 released following administration of anti-RT6.1 monoclonal antibody.

H. Brewer, J. Moss, D. Greiner, 1998, Journal of immunology.

Human apolipoprotein mutants III : diagnosis and treatment

G. Franceschini, C. Sirtori, H. Brewer, 1993 .

Intracellular trafficking of the free cholesterol derived from LDL cholesteryl ester is defective in vivo in Niemann-Pick C disease: insights on normal metabolism of HDL and LDL gained from the NP-C mutation.

R. Brady, H. Brewer, R. Shamburek, 1997, Journal of lipid research.

Type III hyperlipoproteinemia: Quantification, distribution, and nature of atherosclerotic coronary arterial narrowing in five necropsy patients.

R. Virmani, W. Roberts, H. Brewer, 1981, American heart journal.

Conditional Disruption of the Peroxisome Proliferator-Activated Receptor γ Gene in Mice Results in Lowered Expression of ABCA1, ABCG1, and apoE in Macrophages and Reduced Cholesterol Efflux

C. Glass, H. Brewer, C. Nicol, 2002, Molecular and Cellular Biology.

ATP Binding Cassette A1 Transporter Function and Tangier Disease

H. Brewer, E. Schaefer, 2010 .

ATVB In Focus Role of ABCA1 in Cellular Cholesterol Efflux and Reverse Cholesterol Transport

H. Brewer, L. Freeman, S. Santamarina-Fojo, 2003 .

Role of the hepatic ABCA1 transporter in modulating intrahepatic cholesterol and plasma HDL cholesterol concentrations Published, JLR Papers in Press, November 4, 2002. DOI 10.1194/jlr.M200414-JLR200

H. Brewer, A. Remaley, T. Tansey, 2003, Journal of Lipid Research.

Study of ABCA1 function in transgenic mice.

H. Brewer, L. Freeman, S. Santamarina-Fojo, 2003, Arteriosclerosis, thrombosis, and vascular biology.

Lipolytic and ligand-binding functions of hepatic lipase protect against atherosclerosis in LDL receptor-deficient mices⃞ Published, JLR Papers in Press, October 27, 2006.

H. Brewer, R. Shamburek, B. Paigen, 2007, Journal of Lipid Research.

Evaluation of urinary cells in acid cholesteryl ester hydrolase deficiency

H. Brewer, J. Hoeg, P. Kwiterovich, 1986, Clinical genetics.

Enhanced apolipoprotein E production with normal hepatic mRNA levels in the Watanabe heritable hyperlipidemic rabbit.

R. Gregg, H. Brewer, J. Hoeg, 1988, Arteriosclerosis.

Adrenal cholesterol uptake from plasma lipoproteins: regulation by corticotropin.

H. Brewer, J. Gwynne, R. Ney, 1976, Proceedings of the National Academy of Sciences of the United States of America.

Familial apolipoprotein E deficiency and type III hyperlipoproteinemia due to a premature stop codon in the apolipoprotein E gene.

H. Brewer, J. Larosa, S. Skarlatos, 1992, Journal of lipid research.

Modulation of the enzymic activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase by multiple kinase systems involving reversible phosphorylation: a review.

H. Brewer, Z. Beg, J. Stonik, 1987, Metabolism: clinical and experimental.

Apolipoprotein E expression by human-monocyte-derived macrophages. Modulation by opsonised zymosan and cholesterol.

H. Brewer, T. Eggerman, M. Rouis, 1990, European journal of biochemistry.

Recent Studies on the Molecular Defect in Apolipoprotein E Deficiency

R. Gregg, H. Brewer, S. Law, 1986 .

Vitamin A and vitamin E replacement in abetalipoproteinemia.

H. Brewer, E. Schaefer, J. Hoeg, 1984, Annals of internal medicine.

In vitro activation of the enzymic activity of hepatic lipase by apoA‐II

H. Brewer, E. Schaefer, J. C. Osborne, 1981, FEBS letters.

The Ligand-binding Function of Hepatic Lipase Modulates the Development of Atherosclerosis in Transgenic Mice*

H. Brewer, R. Shamburek, B. Paigen, 2004, Journal of Biological Chemistry.

Apolipoprotein E-1Harrisburg: a new variant of apolipoprotein E dominantly associated with type III hyperlipoproteinemia.

R. Gregg, H. Brewer, D. Sprecher, 1989, Biochimica et biophysica acta.

HDL: structure, function and metabolism.

D. Rader, H. Brewer, 1991, Progress in lipid research.

The association of LDL receptor activity, LDL cholesterol level, and clinical course in homozygous familial hypercholesterolemia.

R. Gregg, H. Brewer, E. Lakatos, 1985, Metabolism: clinical and experimental.

Impaired adrenal reserve in the Watanabe Heritable Hyperlipidemic rabbit: implications for LDL-receptor function in steroidogenesis.

W. Green, R. Gregg, H. Brewer, 1985, Metabolism: clinical and experimental.

In vivo modulation of rat liver 3-hydroxy-3-methylglutaryl-coenzyme A reductase, reductase kinase, and reductase kinase kinase by mevalonolactone.

H. Brewer, Z. Beg, J. Stonik, 1984, Proceedings of the National Academy of Sciences of the United States of America.

In vitro and in vivo phosphorylation of rat liver 3-hydroxy-3-methylglutaryl coenzyme A reductase and its modulation by glucagon.

H. Brewer, Z. Beg, J. Stonik, 1980, The Journal of biological chemistry.

Abnormal in vivo metabolism of apoB-containing lipoproteins in human apoE deficiency Published, JLR Papers in Press, April 21, 2004. DOI 10.1194/jlr.M400020-JLR200

D. Rader, H. Brewer, R. Shamburek, 2004, Journal of Lipid Research.

A comparison of Lp(a) levels in fresh and frozen plasma using ELISAs with either anti-apo(a) or anti-apoB reporting antibodies.

D. Rader, H. Brewer, D. Usher, 1994, Chemistry and physics of lipids.

Elevated Plasma Lipoprotein(a) in Patients with the Nephrotic Syndrome

D. Rader, C. Wanner, H. Brewer, 1993, Annals of Internal Medicine.

Homozygous familial hypobetalipoproteinemia. Increased LDL catabolism in hypobetalipoproteinemia due to a truncated apolipoprotein B species, apo B-87Padova.

H. Brewer, G. Crepaldi, A. Corsini, 1996, Arteriosclerosis, thrombosis, and vascular biology.

Increasing HDL Cholesterol Levels.

H. Brewer, H. Bryan Brewer, 2004, The New England journal of medicine.

Genetic polymorphism of human plasma apolipoprotein A-IV is due to nucleotide substitutions in the apolipoprotein A-IV gene.

D. Rader, H. Brewer, M. Kindt, 1990, The Journal of biological chemistry.

3-Hydroxy-3-methylglutaryl coenzyme A reductase: regulation of enzymatic activity by phosphorylation and dephosphorylation.

H. Brewer, Z. Beg, J. Stonik, 1978, Proceedings of the National Academy of Sciences of the United States of America.

Phosphorylation and Modulation of Enzymic Activity of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase by Multiple Kinases

H. Brewer, Z. Beg, J. Stonik, 1989 .

Identification and management of heterozygous familial hypercholesterolemia: summary and recommendations from an NHLBI workshop.

D. Bild, H. Brewer, E. Stein, 1993, American Journal of Cardiology.

Homozygous hypobetalipoproteinemia: transcriptional regulation and 5'-flanking sequence analysis in an apolipoprotein B deficiency state.

R. Gregg, H. Brewer, J. Hoeg, 1989, Biochimica et biophysica acta.

Identification of a novel in-frame translational stop codon in human intestine apoB mRNA.

H. Brewer, K. Higuchi, A. Hospattankar, 1987, Biochemical and biophysical research communications.

The human apoB-100 gene: apoB-100 is encoded by a single copy gene in the human genome.

S. Naylor, H. Brewer, A. Sakaguchi, 1987, Biochemical and biophysical research communications.

Human apolipoprotein B-100: cloning, analysis of liver mRNA, and assignment of the gene to chromosome 2.

S. Naylor, H. Brewer, K. Lackner, 1985, Proceedings of the National Academy of Sciences of the United States of America.

3-Hydroxy-3-methylglutaryl coenzyme A reductase from avian liver. Catalytic properties.

H. Brewer, Z. Beg, J. Stonik, 1979, Biochimica et biophysica acta.

Solubilization of 3-hydroxy-3-methylglutaryl coenzyme A reductase from rat and chicken liver microsomes.

H. Brewer, Z. Beg, J. Stonik, 1978, Analytical biochemistry.

Editorial: Osteoclastic bone resorption and the hypercalcemia of cancer.

H. Brewer, 1974, The New England journal of medicine.

Lipoprotein abnormalities in primary biliary cirrhosis

J. Hoofnagle, H. Brewer, E. Schaefer, 1985 .

NIH conference. Type III hyperlipoproteinemia: diagnosis, molecular defects, pathology, and treatment.

R. Gregg, H. Brewer, E. Schaefer, 1983, Annals of internal medicine.

Testicular function in type II hyperlipoproteinemic patients treated with lovastatin (mevinolin) or neomycin.

H. Brewer, J. Hoeg, E. Brittain, 1987, Journal of Clinical Endocrinology and Metabolism.

A novel missense mutation in the C-terminal domain of lipoprotein lipase (Glu410-->Val) leads to enzyme inactivation and familial chylomicronemia.

H. Brewer, K. Dugi, L. Previato, 1994, Journal of lipid research.

A summary of implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines.

S. Grundy, J. Cleeman, Sidney C. Smith, 2004, Arteriosclerosis, thrombosis, and vascular biology.

Characterization and regulation of reductase kinase, a protein kinase that modulates the enzymic activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

H. Brewer, Z. Beg, J. Stonik, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Lipoprotein lipaseBethesda: a single amino acid substitution (Ala-176----Thr) leads to abnormal heparin binding and loss of enzymic activity.

H. Brewer, J. Brunzell, L. Previato, 1990, Proceedings of the National Academy of Sciences of the United States of America.

An initiation codon mutation in the apoC-II gene (apoC-II Paris) of a patient with a deficiency of apolipoprotein C-II.

H. Brewer, J. Truffert, C. Parrott, 1989, The Journal of biological chemistry.

Analysis of the apoC-II gene in apoC-II deficient patients.

R. Gregg, H. Brewer, D. Sprecher, 1984, Biochemical and biophysical research communications.

Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

H. Brewer, H. Potter, Huntington Potter, 1994, Nature.

Human hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase: evidence for the regulation of enzymic activity by a bicyclic phosphorylation cascade.

H. Brewer, Z. Beg, J. Stonik, 1984, Biochemical and biophysical research communications.

Expression of apolipoprotein B mRNAs encoding higher- and lower-molecular weight isoproteins in rat liver and intestine

H. Brewer, K. Higuchi, G. Tennyson, 2022 .

Absence of triglyceride accumulation in lipoprotein lipase-deficient human monocyte-macrophages incubated with human very low density lipoprotein.

H. Brewer, S. Skarlatos, H. Kruth, 1993, The Journal of clinical endocrinology and metabolism.

Clinical Features, Lipoprotein Characterization, Lipase Activity, and Correction of Hypertriglyceridemia after Apolipoprotein C-Il Administration in Two Affected Patients

H. Brewer, E. Manzato, G. Enzi, 1986 .

Apo C-IIPadova: A New Apoprotein Variant in Two Patients with Apo C-II Deficiency Syndrome

H. Brewer, E. Manzato, G. Crepaldi, 1986 .

The self-association of the reduced ApoA-II apoprotein from the human high density lipoprotein complex.

H. Brewer, G. Palumbo, H. Edelhoch, 1975, Biochemistry.

Abetalipoproteinemia. New insights into lipoprotein assembly and vitamin E metabolism from a rare genetic disease.

D. Rader, H. Brewer, 1993, JAMA.

Studies on Glycogen Synthase and Its Control by Hormones

F. Murad, H. Brewer, G. Brooker, 1974 .

Vitamin E dose-response studies in humans with use of deuterated RRR-a-tocopherol 1 – 3

D. Rader, H. Brewer, M. Traber, 2022 .

Heterogeneityof LipoproteinElectrophoreticPatternsin PatientswithType HaHyperlipoproteinemia

N. Papadopoulos, R. Gregg, H. Brewer, 2004 .

Identification of sequence homology between human plasma apolipoprotein B-100 and apolipoprotein B-48.

H. Brewer, A. Hospattankar, R. Ronan, 1986, The Journal of biological chemistry.

Lipid-protein interactions in high density lipoproteins.

G. Assmann, H. Brewer, 1974, Proceedings of the National Academy of Sciences of the United States of America.

Expression of apolipoprotein B mRNAs encoding higher- and lower-molecular weight isoproteins in rat liver and intestine.

H. Brewer, K. Higuchi, C. A. Sabatos, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Amino acid sequence of human plasma apolipoprotein C-II from normal and hyperlipoproteinemic subjects.

H. Brewer, A. Hospattankar, R. Ronan, 1984, The Journal of biological chemistry.

Apolipoprotein E Modulates the Metabolism of Apolipoprotein B Containing Lipoproteins by Multiple Mechanisms

R. Gregg, H. Brewer, C. Gabelli, 1989 .

Cholesteryl Ester Transfer Protein: A Novel Target for Raising HDL and Inhibiting Atherosclerosis

D. Rader, C. Hennekens, P. Barter, 2003, Arteriosclerosis, thrombosis, and vascular biology.

Increased prevalence of apolipoprotein E4 in type V hyperlipoproteinemia.

R. Gregg, H. Brewer, E. Schaefer, 1982, The Journal of clinical investigation.

Characterization of the plasma lipoproteins and apoproteins of the Erythrocebus patas monkey.

R. Mahley, H. Brewer, K. Weisgraber, 1976, Biochemistry.

Synthetic amphipathic helical peptides promote lipid efflux from cells by an ABCA1-dependent and an ABCA1-independent pathway Published, JLR Papers in Press, January 16, 2003. DOI 10.1194/jlr.M200475-JLR200

H. Brewer, A. Remaley, T. Eggerman, 2003, Journal of Lipid Research.

Human parathyroid hormone: amino-acid sequence of the amino-terminal residues 1-34.

H. Brewer, C. Arnaud, R. Ronan, 1972, Proceedings of the National Academy of Sciences of the United States of America.

The Management of Hyperlipoproteinemia-Reply

R. Gregg, H. Brewer, J. Hoeg, 1986 .

Comparative in vivo metabolism of apolipoproteins E2 and E4 in heterozygous apoE2/4 subjects.

D. Rader, H. Brewer, L. Zech, 2002, The Journal of laboratory and clinical medicine.

PHENOTYPE STUDY OF APOLIPOPROTEIN E ISOFORMS IN HYPERLIPOPROTEINAEMIC PATIENTS

R. Gregg, H. Brewer, E. Schaefer, 1982, The Lancet.

Isolation and immunological characterization of 3-hydroxy-3-methylglutaryl coenzyme A reductase from human liver.

H. Brewer, Z. Beg, J. Stonik, 1982, Biochemical and biophysical research communications.

The molecular behavior of apoA-I in human high density lipoproteins.

H. Brewer, H. Edelhoch, J. Gwynne, 1975, The Journal of biological chemistry.

Post-Translational Modification by Covalent Phosphorylation of Human Apolipoprotein B-100

H. Brewer, J. Hoeg, Z. Beg, 1995 .

Isolation and characterization of the tryptic and cyanogen bromide peptides of apoLp-Gln-II (apoA-II), plasma high density apolipoprotein.

H. Brewer, K. John, S. Lux, 1972, The Journal of biological chemistry.

Developmental Regulation of Apolipoprotein B mRNA Editing Is an Autonomous Function of Small Intestine Involving Homeobox Gene Cdx1*

H. Brewer, T. Eggerman, J. Iovanna, 2003, The Journal of Biological Chemistry.

Apolipoprotein A-I isoprotein synthesis by the perfused rat liver.

H. Brewer, H. G. Windmueller, G. Ghiselli, 1982, Biochemical and biophysical research communications.

Apolipoprotein C‐ll deficiency syndrome due to apo C‐IIHamburg: clinical and biochemical features and Hphl restriction enzyme polymorphism

H. Brewer, U. Beisiegel, F. Beil, 1992, European journal of clinical investigation.

Nucleotide sequence and the encoded amino acids of human apolipoprotein A-I mRNA.

H. Brewer, S. Law, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Heterozygosity for apolipoprotein E-4Philadelphia(Glu13----Lys, Arg145----Cys) is associated with incomplete dominance of type III hyperlipoproteinemia.

D. Rader, H. Brewer, P. Lohse, 1992, The Journal of biological chemistry.

In Vitro Expression of Structural Defects in the Lecithin-Cholesterol Acyltransferase Gene (*)

H. Klein, H. Brewer, S. Marcovina, 1995, The Journal of Biological Chemistry.

Isolation and characterization of an apoA-II-containing lipoprotein (LP-A-II:B complex) from plasma very low density lipoproteins of patients with Tangier disease and type V hyperlipoproteinemia.

R. Gregg, H. Brewer, C. S. Wang, 1991, Journal of lipid research.

The self-association of apoA-II, an apoprotein of the human high density lipoprotein complex.

H. Brewer, G. Palumbo, H. Edelhoch, 1975, Archives of biochemistry and biophysics.

Sicca-like syndrome in type V hyperlipoproteinemia.

H. Brewer, E. Schaefer, H. Moutsopoulos, 1980, Arthritis and rheumatism.

Structural studies on rabbit muscle glycogen synthase. I. Subunit composition.

H. Brewer, J. Larner, Y. Takeda, 1975, The Journal of biological chemistry.

Apolipoprotein E deficiency in mice: gene replacement and prevention of atherosclerosis using adenovirus vectors.

H. Brewer, N. Maeda, V. Kashyap, 1995, The Journal of clinical investigation.

Abnormal in vivo metabolism of apolipoprotein E4 in humans.

R. Gregg, H. Brewer, E. Schaefer, 1986, The Journal of clinical investigation.

Effects of the CETP inhibitor evacetrapib administered as monotherapy or in combination with statins on HDL and LDL cholesterol: a randomized controlled trial.

Ming-Dauh Wang, M. Shao, J. Kastelein, 2011, JAMA.

Counter-current chromatography of lipoproteins with a polymer phase system using the cross-axis synchronous coil planet centrifuge.

D. Rader, H. Brewer, Y. Ito, 1992, Journal of chromatography.

Definition of Metabolic Syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association Conference on Scientific Issues Related to Definition

Claude Lenfant, R. Krauss, R. Holman, 2004, Arteriosclerosis, thrombosis, and vascular biology.

The plasma lipoproteins.

H. Brewer, J. C. Osborne, James C. Osborne, 1977, Advances in protein chemistry.

PPAR-α and PPAR-γ activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway

M. Jaye, H. Brewer, A. Remaley, 2001, Nature Medicine.

Definition of Metabolic Syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association Conference on Scientific Issues Related to Definition

Claude Lenfant, S. Grundy, J. Cleeman, 2004, Circulation.

In Vivo Metabolism of a Mutant Apolipoprotein A-I (ARG-26) Associated with Hereditary Amyloidosis

D. Rader, R. Gregg, H. Brewer, 1991 .

Hypertriglyceridemia: changes in the plasma lipoproteins associated with an increased risk of cardiovascular disease.

H. Brewer, H. Brewer, 1999, The American journal of cardiology.

Characterization of neutral and acid ester hydrolase in Wolman's disease.

H. Brewer, J. Hoeg, S. Demosky, 1982, Biochimica et biophysica acta.

Effects of nitrogen mustard on the physicochemical properties of mouse fibroblast deoxyribonucleic acid.

H. Brewer, L. Aronow, 1963, Cancer research.

Cholesterol efflux and atheroprotection: advancing the concept of reverse cholesterol transport.

Zahi A Fayad, Valentin Fuster, V. Fuster, 2012, Circulation.

New micromethod for measuring cholesterol in plasma lipoprotein fractions.

H. Brewer, T. J. Bronzert, 1977, Clinical chemistry.

Human ApoB-100 gene resides in the p23----pter region of chromosome 2.

S. Naylor, H. Brewer, A. Sakaguchi, 1985, Biochemical and biophysical research communications.

Effect of ACAT inhibition on the progression of coronary atherosclerosis.

Carl J Pepine, Paul Schoenhagen, E. Michelson, 2006, The New England journal of medicine.

Effect of gangliosides and substrate analogues on the hydrolysis of nicotinamide adenine dinucleotide by choleragen.

R. Brady, H. Brewer, J. Moss, 1977, Proceedings of the National Academy of Sciences of the United States of America.

Dysfunctional HDL and atherosclerotic cardiovascular disease

P. Barter, A. Tall, H. Brewer, 2016, Nature Reviews Cardiology.

Homozygous hypobetalipoproteinemia: a disease distinct from abetalipoproproteinemia at the molecular level.

T. Triche, R. Gregg, H. Brewer, 1988, The Journal of clinical investigation.

Fish eye syndrome: a molecular defect in the lecithin-cholesterol acyltransferase (LCAT) gene associated with normal alpha-LCAT-specific activity. Implications for classification and prognosis.

H. Klein, H. Brewer, S. Marcovina, 1993, The Journal of clinical investigation.

Two different allelic mutations in the lecithin:cholesterol acyltransferase (LCAT) gene resulting in classic LCAT deficiency: LCAT (tyr83-->stop) and LCAT (tyr156-->asn).

D. Rader, H. Klein, H. Brewer, 1993, Journal of lipid research.

Two different allelic mutations in the lecithin-cholesterol acyltransferase gene associated with the fish eye syndrome. Lecithin-cholesterol acyltransferase (Thr123----Ile) and lecithin-cholesterol acyltransferase (Thr347----Met).

H. Klein, H. Brewer, P. Pritchard, 1992, The Journal of clinical investigation.

Transcriptional regulation of the human lipoprotein lipase gene in 3T3-L1 adipocytes.

H. Brewer, L. Previato, S. Santamarina-Fojo, 1991, The Journal of biological chemistry.

Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively.

A. Pandya, A. Brooks-Wilson, H. Brewer, 2001, American journal of human genetics.

Alzheimer Aβ neurotoxicity: Promotion by antichymotrypsin, ApoE4; inhibition by Aβ-related peptides

H. Brewer, H. Potter, Huntington Potter, 1996, Neurobiology of Aging.

Benefit-risk assessment of Rosuvastatin 10 to 40 milligrams.

H. Brewer, H. Brewer, 2003, The American journal of cardiology.

HDL and atherosclerotic cardiovascular disease: genetic insights into complex biology

Jean-Claude Tardif, Frank M. Sacks, Robert A. Hegele, 2018, Nature Reviews Cardiology.

Neomycin and plasma lipoproteins in type II hyperlipoproteinemia

K. Bailey, P. Wilson, R. Gregg, 1984, Clinical pharmacology and therapeutics.

Discrimination between RRR- and all-racemic-alpha-tocopherols labeled with deuterium by patients with abetalipoproteinemia.

D. Rader, H. Brewer, M. Traber, 1994, Atherosclerosis.

Rapid in vivo transport and catabolism of human apolipoprotein A-IV-1 and slower catabolism of the apoA-IV-2 isoprotein.

D. Rader, H. Brewer, B. Vergès, 1993, The Journal of clinical investigation.

Human Apolipoprotein A-IV

H. Brewer, P. Lohse, 1993 .

Effects of nitrogen mustard on protein and nucleic acid synthesis in mouse fibroblasts growing in vitro.

H. Brewer, J. Comstock, L. Aronow, 1961, Biochemical pharmacology.

PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway.

M. Jaye, H. Brewer, A. Remaley, 2000, Nature medicine.

Metabolic syndrome: the dysmetabolic state of dysfunctional adipose tissue and insulin resistance

J. Després, H. Brewer, J. Despres, 2008 .

Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1

J. Piette, G. Assmann, P. Denéfle, 1999, Nature Genetics.

The Farnesoid X-receptor Is an Essential Regulator of Cholesterol Homeostasis*

Grace Guo, H. Brewer, F. Gonzalez, 2003, The Journal of Biological Chemistry.

The use of parenteral hyperalimentation and elemental formula feeding in the treatment of Wolman disease

H. Brewer, J. Hoeg, S. Demosky, 1985 .

beta 2-Glycoprotein I. Molecular properties of an unusual apolipoprotein, apolipoprotein H.

H. Brewer, J. C. Osborne, N. Lee, 1983, The Journal of biological chemistry.

Three genetic variants of human plasma apolipoprotein A-IV. apoA-IV-1(Thr347----Ser), apoA-IV-0(Lys167----Glu,Gln360----His), and apoA-IV-3(Glu165----Lys).

D. Rader, H. Brewer, M. Kindt, 1991, The Journal of biological chemistry.

Exon 10 skipping caused by intron 10 splice donor site mutation in cholesteryl ester transfer protein gene results in abnormal downstream splice site selection.

S. Yamashita, Y. Matsuzawa, H. Brewer, 1996, Journal of lipid research.

The amino acid sequence of human APOA-I, an apolipoprotein isolated from high density lipoproteins.

H. Brewer, T. J. Bronzert, R. Ronan, 1978, Biochemical and biophysical research communications.

Therapeutic response to medium-chain triglycerides and omega-3 fatty acids in a patient with the familial chylomicronemia syndrome.

H. Brewer, J. Brunzell, K. Dugi, 1997, Arteriosclerosis, thrombosis, and vascular biology.

Amino acid sequence of bovine thyrocalcitonin.

H. Brewer, R. Ronan, 1969, Proceedings of the National Academy of Sciences of the United States of America.

Increased catabolic rate of low density lipoproteins in humans with cholesteryl ester transfer protein deficiency.

D. Rader, H. Brewer, T. Ishikawa, 1995, The Journal of clinical investigation.

Evaluation of apoA-I kinetics in humans using simultaneous endogenous stable isotope and exogenous radiotracer methods.

D. Rader, H. Brewer, T Fairwell, 1993, Journal of lipid research.

Human ATP-binding cassette transporter 1 (ABC1): genomic organization and identification of the genetic defect in the original Tangier disease kindred.

P. Denéfle, H. Brewer, M. Dinger, 1999, Proceedings of the National Academy of Sciences of the United States of America.

A nonsense mutation in the apolipoprotein C-IIPadova gene in a patient with apolipoprotein C-II deficiency.

H. Brewer, C. Gabelli, G. Baggio, 1989, The Journal of clinical investigation.

The Molecular Basis of ApoC-II Deficiency

R. Gregg, H. Brewer, A. Stalenhoef, 1989 .

Donor splice site mutation in the apolipoprotein (Apo) C-II gene (Apo C-IIHamburg) of a patient with Apo C-II deficiency.

R. Gregg, H. Brewer, U. Beisiegel, 1988, The Journal of clinical investigation.

Apolipoprotein C-II deficiency: identification of a structural variant ApoC-II Padova.

R. Gregg, H. Brewer, C. Gabelli, 1988, Biochemical and biophysical research communications.

Genomic Structure, Biosynthesis, and Processing of Preproapolipoprotein C-II

H. Brewer, J. Hoeg, D. Sprecher, 1987 .

High-density lipoproteins: a new potential therapeutic target for the prevention of cardiovascular disease.

H. Brewer, H. Brewer, H. Bryan Brewer, 2004, Arteriosclerosis, thrombosis, and vascular biology.

Peroxisome Proliferator-activated Receptor β/δ Regulates Very Low Density Lipoprotein Production and Catabolism in Mice on a Western Diet*

H. Brewer, C. Nicol, J. Peters, 2004, Journal of Biological Chemistry.

Overexpression of Human Lecithin Cholesterol Acyltransferase Leads to Hyperalphalipoproteinemia in Transgenic Mice (*)

R. F. Hoyt, H. Klein, H. Brewer, 1995, The Journal of Biological Chemistry.

The human apolipoprotein A-II gene is located on chromosome 1.

S. Naylor, H. Brewer, K. Lackner, 1984, Biochemical and biophysical research communications.

Gene therapy for the genetic dyslipoproteinaemias

H. Brewer, J. Hoeg, N. Maeda, 1995 .

Clinical review: The evolving role of HDL in the treatment of high-risk patients with cardiovascular disease.

H. Brewer, H. Brewer, 2011, The Journal of clinical endocrinology and metabolism.

High-Density Lipoprotein Metabolism

H. Brewer, 2011 .

A first-in-man, randomized, placebo-controlled study to evaluate the safety and feasibility of autologous delipidated high-density lipoprotein plasma infusions in patients with acute coronary syndrome.

P. Fitzgerald, N. Weissman, H. Brewer, 2010, Journal of the American College of Cardiology.

HDL metabolism and the role of HDL in the treatment of high-risk patients with cardiovascular disease

H. Brewer, H. Bryan Brewer, H. Brewer, 2007, Current cardiology reports.

Hepatic lipase promotes the selective uptake of high density lipoprotein-cholesteryl esters via the scavenger receptor B 1

H. Brewer, K. Dugi, A. Bensadoun, 1999 .

New Insights into the Role of HDL in the Development of Cardiovascular Disease

H. Brewer, 1998 .

In vivo metabolism of apolipoprotein A-I on high density lipoprotein particles LpA-I and LpA-I,A-II.

D. Rader, H. Brewer, J. Fruchart, 1991, Journal of lipid research.

The human apolipoprotein A-II gene: complete nucleic acid sequence and genomic organization.

H. Brewer, K. Lackner, S. Law, 1985, Nucleic acids research.

ApoE deficiency: markedly decreased levels of cellular ApoE mRNA.

R. Gregg, H. Brewer, S. Law, 1986, Biochemical and biophysical research communications.

The ATP binding cassette transporter A1 (ABCA1) modulates the development of aortic atherosclerosis in C57BL/6 and apoE-knockout mice

R. F. Hoyt, H. Brewer, A. Remaley, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Novel Therapies Focused on the High-Density Lipoprotein Particle

J. Kastelein, J. Kastelein, G. Hovingh, 2014, Circulation research.

ABCA1 overexpression leads to hyperalphalipoproteinemia and increased biliary cholesterol excretion in transgenic mice.

H. Brewer, R. Shamburek, A. Remaley, 2001, The Journal of clinical investigation.

Consensus for the use of fibrates in the treatment of dyslipoproteinemia and coronary heart disease. Fibrate Consensus Group.

A. Gotto, A. Keech, S. Grundy, 1998, The American journal of cardiology.

Evacetrapib and Cardiovascular Outcomes in High-Risk Vascular Disease

P. Barter, A. Lincoff, H. Brewer, 2017 .

Comparison of six pharmacologic regimens for hypercholesterolemia.

K. Bailey, H. Brewer, J. Hoeg, 1987, The American journal of cardiology.

Current Concepts of the Plasma Lipoproteins and Their Role in Atherosclerosis

H. Brewer, 1995 .

Metabolism of human apolipoproteins A-I and A-II: compartmental models.

H. Brewer, E. Schaefer, R. Aamodt, 1983, Journal of lipid research.

Human apolipoprotein A-I and A-II metabolism.

H. Brewer, E. Schaefer, R. Aamodt, 1982, Journal of lipid research.

The Role of HDLC in the Management of Atherosclerosis Moderated

D. Rader, J. Tardif, H. Brewer, 2012 .

Lcat overexpression in different animal models: modulation of atherosclerosis by CETP, HL and apoA-1

H. Brewer, J. Hoeg, C. Koch, 1999 .

Intravascular ultrasound analysis to determine the relationship between high-density lipoprotein cholesterol and lesion characteristics in patients with coronary artery disease.

H. Brewer, A. Pichard, R. Torguson, 2014, Journal of interventional cardiology.

The human ABCG1 gene: identification of LXR response elements that modulate expression in macrophages and liver Published, JLR Papers in Press, July 16, 2005. DOI 10.1194/jlr.M500080-JLR200

H. Brewer, S. Sabol, S. Santamarina-Fojo, 2005, Journal of Lipid Research.

New insights into the role of the adenosine triphosphate-binding cassette transporters in high-density lipoprotein metabolism and reverse cholesterol transport.

H. Brewer, H Bryan Brewer, Silvia Santamarina-Fojo, 2003, The American journal of cardiology.

In vivo metabolism of a mutant form of apolipoprotein A-I, apo A-IMilano, associated with familial hypoalphalipoproteinemia.

G. Franceschini, C. Sirtori, R. Gregg, 1993, The Journal of clinical investigation.

Apolipoprotein A-IMilano: In Vivo Metabolism of an Apolipoprotein A-I Variant

G. Franceschini, C. Sirtori, H. Brewer, 1986 .

Human apolipoprotein A-I and C-III genes reside in the p11----q13 region of chromosome 11.

S. Naylor, H. Brewer, A. Sakaguchi, 1984, Biochemical and biophysical research communications.

Identification of patients and plaques vulnerable to future coronary events with near-infrared spectroscopy intravascular ultrasound imaging: a prospective, cohort study

Habib Samady, Francesco Prati, Eric Powers, 2019, The Lancet.

Ocular manifestations of familial high-density lipoprotein deficiency (Tangier disease).

D. Cogan, H. Brewer, E. Schaefer, 1979, Archives of ophthalmology.

The ABCA1 Transporter Modulates Late Endocytic Trafficking INSIGHTS FROM THE CORRECTION OF THE GENETIC DEFECT IN TANGIER DISEASE* □ S

H. Brewer, A. Remaley, C. Combs, 2004 .

Relative biologic activities of human and bovine parathyroid hormones and their synthetic, NH2-terminal (1-34) peptides, as evaluated in vitro with renal cortical adenylate cyclase obtained from three different species.

H. Brewer, C. Arnaud, F. D. Di Bella, 1976, Endocrinology.

Recent studies on the chemistry of human, bovine and porcine parathyroid hormones.

H. Brewer, C. Arnaud, T. Fairwell, 1974, The American journal of medicine.

Alzheimer A beta neurotoxicity: promotion by antichymotrypsin, ApoE4; inhibition by A beta-related peptides.

J. Ma, H. Brewer, H. Potter, 1996, Neurobiology of aging.

Apolipoprotein EBethesda Isolation and partial characterization of a variant of human apolipoprotein e isolated from very low density lipoproteins

R. Gregg, H. Brewer, G. Ghiselli, 1984 .

Isolation and characterization of apoLp-Gln-II (apoA-II), a plasma high density apolipoprotein containing two identical polypeptide chains.

H. Brewer, K. John, S. Lux, 1972, The Journal of biological chemistry.

Metabolism of high density lipoprotein subfractions and constituents in Tangier disease following the infusion of high density lipoproteins.

H. Brewer, E. Schaefer, E J Schaefer, 1981, Journal of lipid research.

The Role of Apolipoprotein E and the Low-Density Lipoprotein Receptor in Modulating the in Vivo Metabolism of Apolipoprotein-B-Containing Lipoproteins

R. Gregg, H. Brewer, J. Hoeg, 1987 .

The localization of the gene for apolipoprotein C-II to chromosome 19.

S. Naylor, H. Brewer, A. Sakaguchi, 1984, Biochemical and biophysical research communications.

Purification and characterization of apolipoprotein C-II from human plasma by high-pressure liquid chromatography.

H. Brewer, L. Kay, R. Ronan, 1982, Biochimica et biophysica acta.

The thermodynamics of the self-association of the reduced and carboxymethylated form of apo-a-II from the human high density lipoprotein complex.

H. Brewer, G. Palumbo, H. Edelhoch, 1976, Biochemistry.

Characterization of single base substitutions in edited apolipoprotein B transcripts.

H. Brewer, T. Eggerman, C. A. Sabatos, 1989, Nucleic acids research.

Complete genomic sequence of the human ABCA1 gene: analysis of the human and mouse ATP-binding cassette A promoter.

J. Cheng, E. Rubin, P. Denéfle, 2000, Proceedings of the National Academy of Sciences of the United States of America.

The amino acid sequence of porcine thyrocalcitonin.

H. Brewer, L. Deftos, H. Keutmann, 1968, Proceedings of the National Academy of Sciences of the United States of America.

Human preproapolipoprotein C-II. Analysis of major plasma isoforms.

H. Brewer, J. Hoeg, D. Sprecher, 1986, The Journal of biological chemistry.

The Complete Amino Acid Sequence of Alanine Apolipoprotein (apoC-III), an Apolipoprotein from Human Plasma Very Low Density Lipoproteins

H. Brewer, P. Herbert, R. Ronan, 1974 .

Parathyroid Hormone: Structure and Immunoheterogeneity

H. Brewer, C. Arnaud, Claude E. Arnaud, 1975 .

Bovine parathyroid hormone: amino acid sequence.

H. Brewer, R. Ronan, 1970, Proceedings of the National Academy of Sciences of the United States of America.

The interaction of apoA-I from human high density lipoprotein with lysolecithin.

H. Brewer, G. Palumbo, H. Edelhoch, 1975, The Journal of biological chemistry.

Effect of pressure and ionic strength on the self-association of Apo-A-I from the human high density lipoprotein complex.

S. Formisano, H. Brewer, J. C. Osborne, 1978, The Journal of biological chemistry.

Lipoproteins containing apolipoprotein B isolated from patients with abetalipoproteinemia and homozygous hypobetalipoproteinemia: identification and characterization.

D. Rader, H. Brewer, M. Traber, 1995, Atherosclerosis.

Serum amyloid A promotes ABCA1-dependent and ABCA1-independent lipid efflux from cells.

H. Brewer, A. Remaley, A. Bocharov, 2004, Biochemical and biophysical research communications.

Cellular Localization and Trafficking of the Human ABCA1 Transporter* 210

H. Brewer, A. Remaley, S. Demosky, 2001, The Journal of Biological Chemistry.

The E-box motif in the proximal ABCA1 promoter mediates transcriptional repression of the ABCA1 gene.

H. Brewer, A. Remaley, L. Freeman, 2002, Journal of lipid research.

Functional characterization of a chimeric lipase genetically engineered from human lipoprotein lipase and human hepatic lipase.

H. Brewer, J. Brunzell, S. Santamarina-Fojo, 1993, Journal of lipid research.

Plasma apolipoprotein concentrations in familial apolipoprotein A-I and A-II deficiency (Tangier disease).

H. Brewer, E. Schaefer, P. Alaupovic, 1981, Metabolism: clinical and experimental.

Petar Alaupovic: The father of lipoprotein classification based on apolipoprotein composition.

F. Sacks, H. Brewer, 2014, Arteriosclerosis, thrombosis, and vascular biology.

In vivo kinetics of a mutant protein, APO A-I IOWA

D. Rader, R. Gregg, H. Brewer, 1992 .

Carboxyl-terminal Domain Truncation Alters Apolipoprotein A-I in Vivo Catabolism (*)

H. Brewer, J. Hoeg, A. Remaley, 1995, The Journal of Biological Chemistry.

A deletion mutation in the ApoC-II gene (ApoC-II Nijmegen) of a patient with a deficiency of apolipoprotein C-II.

R. Gregg, H. Brewer, A. Stalenhoef, 1988, The Journal of biological chemistry.

Molecular genetics of apoC-II and lipoprotein lipase deficiency.

H. Brewer, A. Stalenhoef, J. Brunzell, 1991, Advances in experimental medicine and biology.

31P nuclear magnetic resonance spectroscopy of native and recombined lipoproteins.

G. Assmann, H. Brewer, E. Sokoloski, 1974, Proceedings of the National Academy of Sciences of the United States of America.

Editorial to:BStatin-Induced Decrease in ATP-Binding Cassette Transporter A1 Expression via microRNA33 Induction may Counteract Cholesterol Efflux to High Density Lipoprotein^ by E.J. Niesor et al.

H. Brewer, R. Rosenson, 2015 .

Recent Studies on the Metabolic Defect in Tangier Disease

R. Gregg, H. Brewer, S. Law, 1986 .

Aneurysmal coronary artery disease in cerebrotendinous xanthomatosis.

A. Quyyumi, W. Roberts, H. Brewer, 1988, The American journal of cardiology.

Amyloid-associated proteins alpha 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer beta-protein into filaments.

J. Ma, H. Brewer, H. Potter, 1994, Nature.

Human apolipoprotein C-II: complete nucleic acid sequence of preapolipoprotein C-II.

H. Brewer, S. Law, S. Fojo, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Hemoglobin switching in sheep and goats. 3. Cell-free initiation of sheep globin synthesis.

W. Anderson, H. Brewer, N. Elson, 1974, Journal of Biological Chemistry.

3. Genetic (primary) forms of hypertriglceridemia

G. Assmann, H. Brewer, 1991 .

In vivo evidence for both lipolytic and nonlipolytic function of hepatic lipase in the metabolism of HDL.

R. F. Hoyt, H. Brewer, R. Shamburek, 2000, Arteriosclerosis, thrombosis, and vascular biology.

Chemistry and Conformation of the Bovine Parathyroid Hormone

H. Brewer, 1972 .

Isolation and chemical properties of porcine thyrocalcitonin.

H. Brewer, H. Keutmann, J. Potts, 1968, The Journal of biological chemistry.

Human plasma apolipoproteins A-IV-0 and A-IV-3. Molecular basis for two rare variants of apolipoprotein A-IV-1.

D. Rader, H. Brewer, M. Kindt, 1990, The Journal of biological chemistry.

Evaluation of the mixed interaction between apolipoproteins A-II and C-I equilibrium sedimentation.

H. Brewer, J. C. Osborne, L. Servillo, 1981, Biophysical chemistry.

Self-association of apo-C-I from the human high density lipoprotein complex.

H. Brewer, J. C. Osborne, T. J. Bronzert, 1977, The Journal of biological chemistry.

In vivo metabolism of proapolipoprotein A-I in Tangier disease.

R. Gregg, H. Brewer, L. Zech, 1987, The Journal of clinical investigation.

The orphan nuclear receptor LRH-1 activates the ABCG5/ABCG8 intergenic promoter Published, JLR Papers in Press, May 1, 2004. DOI 10.1194/jlr.C400002-JLR200

H. Brewer, A. Remaley, A. Kennedy, 2004, Journal of Lipid Research.

Immunoblot Analysis of the Different Apolipoprotein B Species

R. Gregg, H. Brewer, C. Gabelli, 1986 .

New Challenges for HDL-Modifying Therapies as a Strategy to Lower Cardiovascular Disease Events in Statin-Treated Patients

H. Brewer, R. Rosenson, 2015, Cardiovascular Drugs and Therapy.

The molecular defects in lipoprotein lipase deficient patients

H. Brewer, H. Dichek, O. Beg, 1992, European Journal of Epidemiology.

Effects of Chenodeoxycholic Acid (CD) Treatment on Endogenous Plasma Triglyceride (TG) Transport in Hyperlipoproteinemia (HLP)

T. M. Hayes, M. Freeman, S. Fujii, 1978 .

Phosphorylation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase and modulation of its enzymic activity by calcium-activated and phospholipid-dependent protein kinase.

H. Brewer, Z. Beg, J. Stonik, 1985, The Journal of biological chemistry.

Adrenocortical Function in Type II Hyperlipoproteinemic Patients Treated with Lovastatin (Mevinolin)

K. Bailey, H. Brewer, K. Lackner, 1987, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Comparative genome analysis of potential regulatory elements in the ABCG5-ABCG8 gene cluster.

H. Brewer, A. Remaley, Eric E. Elgin, 2002, Biochemical and biophysical research communications.

Analysis of the Apolipoprotein B Gene and Messenger Ribonucleic Acid in Abetalipoproteinemia

T. Triche, H. Brewer, K. Lackner, 2022 .

New features of the national cholesterol education program adult treatment panel III lipid‐lowering guidelines

H. Brewer, 2003, Clinical cardiology.

A naturally occurring mutation at the second base of codon asparagine 43 in the proposed N-linked glycosylation site of human lipoprotein lipase: in vivo evidence that asparagine 43 is essential for catalysis and secretion.

H. Brewer, H. Inadera, J. Kobayashi, 1994, Biochemical and biophysical research communications.

National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)

J. Mckenney, M. Proschan, S. Grundy, 2015 .

Coronary Atheroma Regression From Infusions of Autologous Selectively Delipidated Preβ-HDL-Enriched Plasma in Homozygous Familial Hypercholesterolemia.

D. Gaudet, P. Shah, H. Brewer, 2020, Journal of the American College of Cardiology.

The complete amino acid sequence of alanine apolipoprotein (apoC-3), and apolipoprotein from human plasma very low density lipoproteins.

H. Brewer, P. Herbert, R. Ronan, 1974, The Journal of biological chemistry.

A novel domain enzyme missense mutation in the C-terminal of lipoprotein lipase (GIu410+Val) leads to inactivation and familial chylomicronemia

H. Brewer, K. Dugi, L. Previato, 1994 .

Isolation of Novel Genes Regulated by Dietary Cholesterol by a Pcr-Based Subtraction Library

H. Brewer, J. Hoeg, A. Remaley, 1995 .

Abetalipoproteinemia: New Insights Into Lipoprotein Assembly and Vitamin E Metabolism From a Rare Genetic Disease

D. Rader, H. Brewer, 1993 .

Cholesterol Efflux Capacity and Pre-Beta-1 HDL Concentrations Are Increased in Dyslipidemic Patients Treated With Evacetrapib.

H. Brewer, S. Nissen, J. Kane, 2015, Journal of the American College of Cardiology.

Workshop on apolipoprotein quantification.

H. Brewer, A. Gotto, H. Tyroler, 1983, Arteriosclerosis.

APOLIPOPROTEIN E ALLELES IN SEVERE HYPERTRIGLYCERIDAEMIA

R. Gregg, H. Brewer, L. Zech, 1983, The Lancet.

Phosphorylation and modulation of the enzymic activity of native and protease-cleaved purified hepatic 3-hydroxy-3-methylglutaryl-coenzyme A reductase by a calcium/calmodulin-dependent protein kinase.

H. Brewer, Z. Beg, J. Stonik, 1987, The Journal of biological chemistry.