H. Hayakawa

发表

Asymmetric total synthesis of PM-toxin A, a corn host-specific pathotoxin

H. Hayakawa, M. Ohmori, Kiyoko Takamichi, 1997 .

Activity against Human Immunodeficiency Virus Type 1, Intracellular Metabolism, and Effects on Human DNA Polymerases of 4′-Ethynyl-2-Fluoro-2′-Deoxyadenosine

Christopher M. Bailey, K. Anderson, Yung-chi Cheng, 2007, Antimicrobial Agents and Chemotherapy.

2′-Deoxy-4′-C-Ethynyl-2-Fluoroadenosine: A Nucleoside Reverse Transcriptase Inhibitor with Highly Potent Activity Against Wide Spectrum of HIV-1 Strains, Favorable Toxic Profiles, and Stability in Plasma

M. Matsuoka, H. Mitsuya, H. Hayakawa, 2007, Nucleosides, nucleotides & nucleic acids.

Potent Activity of a Nucleoside Reverse Transcriptase Inhibitor, 4 (cid:2) -Ethynyl-2-Fluoro-2 (cid:2) -Deoxyadenosine, against Human Immunodeﬁciency Virus Type 1 Infection in a Model Using Human Peripheral Blood Mononuclear Cell-Transplanted NOD/SCID Janus Kinase 3 Knockout Mice (cid:1)

H. Mitsuya, H. Hayakawa, H. Harada, 2009 .

Ring-opening and ring-closing reactions of a shikimic acid-derived substrate leading to diverse small molecules.

John A. Tallarico, S. Schreiber, K. Münger, 2007, Journal of combinatorial chemistry.

First synthesis of enantio-uracil dinucleotide, comparison of physicochemical properties of their enantiomers, and separation by chiral column chromatography

H. Hayakawa, S. Sakata, T. Miyashita, 2003 .

Reaction of organometallic reagents with 2'- and 3'-ketouridine derivatives: Synthesis of uracil nucleosides branched at the 2'- and 3'-positions.

H. Hayakawa, Y. Iitaka, K. Yamaguchi, 1987 .

HEPT: From an Investigation of Lithiation of Nucleosides Towards a Rational Design of Non-Nucleoside Reverse Transcriptase Inhibitors of HIV-1

R. T. Walker, D. Stuart, D. Stammers, 2000 .

Synthesis of novel chiral diazole ligands for enantioselective addition of diethylzinc to benzaldehyde

H. Hayakawa, Masahiro Wakao, H. Kotsuki, 1995 .

The C-2 selective azide opening reaction of trans-2,3-epoxy alcohols by NaN3 and PhB(OH)2

H. Hayakawa, M. Miyashita, M. Miyazawa, 1999 .

Potential of 4′-C-Substituted Nucleosides for the Treatment of HIV-1

H. Mitsuya, H. Hayakawa, H. Ohrui, 2004, Antiviral chemistry & chemotherapy.

2'-Deoxy-4'-C-ethynyl-2-fluoroadenosine: a nucleoside reverse transcriptase inhibitor with highly potent activity against all HIV-1 strains, favorable toxic profiles and stability in plasma.

M. Matsuoka, H. Hayakawa, H. Ohrui, 2006, Nucleic acids symposium series.

Synthesis and biological activities of 5-substituted 6-phenylthio and 6-iodouridines, a new class of antileukemic nucleosides.

A. Matsuda, H. Hayakawa, T. Miyasaka, 1983, Chemical & pharmaceutical bulletin.

A novel lead for specific anti-HIV-1 agents: 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine.

R T Walker, R. T. Walker, E. De Clercq, 1989, Journal of medicinal chemistry.

Antitumor studies. Part 1: design, synthesis, antitumor activity, and AutoDock study of 2-deoxo-2-phenyl-5-deazaflavins and 2-deoxo-2-phenylflavin-5-oxides as a new class of antitumor agents.

Hamed I. Ali, H. Hayakawa, T. Yamagishi, 2007, Bioorganic & medicinal chemistry.

Synthesis of Novel Chiral Diazole Derivative Ligands for the Enantioselective Addition of Diethylzinc to Benzaldehyde.

H. Hayakawa, Masahiro Wakao, M. Shiro, 1996, The Journal of organic chemistry.

An Unusual Reaction Observed in Sulfonylation and Acylation of 2′,3′-O-Isopropylidenenebularine

H. Hayakawa, K. Yamaguchi, T. Miyasaka, 1989 .

FIRST EXCEPTIONS TO THE"IMBACH RULE"FOR β-D-RIBOFURANOSYL NUCLEOSIDES

H. Hayakawa, T. Miyasaka, Hiromichi Tanaka, 1982 .

Synthesis of Novel Chiral Diazole Derivative Ligands for the Enantioselective Addition of Diethylzinc to Benzaldehyde.

H. Hayakawa, Masahiro Wakao, M. Shiro, 1996, The Journal of organic chemistry.

Lithiation of 5,6-dihydrouridine: a new route to 5-substituted uridines

H. Hayakawa, T. Miyasaka, Hiromichi Tanaka, 1985 .

Cleavage of cyclic ethers including oxetane and oxolane with a highly nucleophilic species of phenylselenide anion.

H. Hayakawa, T. Miyasaka, K. Haraguchi, 1988 .

First Evident Generation of Purin-2-yllithium: Lithiation of an 8-Silyl-Protected 6-Chloropurine Riboside as a Key Step for the Synthesis of 2-Carbon-Substituted Adenosines†

H. Hayakawa, T. Miyasaka, H. Kumamoto, 1999 .

An efficient and stereoselective construction of the C(9)–C(17) dihydropyran segment of swinholides A–C via a novel reductive cleavage of an epoxy aldehyde

H. Hayakawa, M. Miyashita, 2000 .

A tandem synthesis of polypropionate chains. Highly stereoselective construction of the C(13)–C(25) segment containing nine contiguous chiral centers of swinholides A–C based on the stereospecific methylation of γ,δ-epoxy acrylates by trimethylaluminium

H. Hayakawa, M. Miyashita, 1999 .

Synthesis and antiviral evaluation of α-D-2',3'-didehydro-2',3'-dideoxy-3'-C-hydroxymethyl nucleosides.

H. Hayakawa, Kohei Yamada, Y. Yoshimura, 2010, Bioorganic & medicinal chemistry letters.

A Novel Route to Pyrimidine Nucleosides via Intramolecular Couplings of Bases with 2′-Deoxyribosides: Quick and Stereospecific...but with a 'Twist'

H. Hayakawa, K. Stevens, B. Lipshutz, 1994 .

A New Entry to 2-Substituted Purine Nucleosides Based on Lithiation-Mediated Stannyl Transfer of 6-Chloropurine Nucleosides

S. Shuto, H. Hayakawa, T. Miyasaka, 1997 .

An Efficient Procedure for Palladium-Catalyzed Reduction of Aryl/Enol Triflates

H. Hayakawa, H. Kotsuki, H. Suenaga, 1995 .

Synthetic route to 5-substituted uridines via a new type of desulfurizative stannylation

H. Hayakawa, Hiromichi Tanaka, K. Obi, 1986 .

Stereospecific ring-opening reaction of epoxy sulfides with phenylboronic acid via episulfonium ions

H. Hayakawa, M. Miyashita, N. Okada, 1999 .

Highly stereoselective total synthesis of PM-Toxin B, a corn host-specific pathotoxin

H. Hayakawa, M. Miyashita, M. Hosaka, 2000 .

A new class of HIV-1-specific 6-substituted acyclouridine derivatives: synthesis and anti-HIV-1 activity of 5- or 6-substituted analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT).

S Shigeta, H. Hayakawa, M. Baba, 1991, Journal of medicinal chemistry.

Direct C-8 lithiation of naturally-occurring purine nucleosides. A simple method for the synthesis of 8-carbon-substituted purine nucleosides

H. Hayakawa, T. Miyasaka, K. Haraguchi, 1987 .

A Ribonolactone-Based Approach to the Synthesis of 1′-Carbon-Substituted Thymine Ribonucleosides

H. Hayakawa, T. Miyasaka, Hiromichi Tanaka, 1994 .

Design, Efficient Synthesis, and Anti‐HIV Activity of 4′‐C‐Cyano‐ and 4′‐C‐Ethynyl‐2′‐deoxy Purine Nucleosides

M. Matsuoka, H. Mitsuya, H. Hayakawa, 2004, Nucleosides, nucleotides & nucleic acids.

A Ribonolactone-Based Approach to the Synthesis of 1′-Carbon- Substituted Thymine Ribonucleosides.

H. Hayakawa, T. Miyasaka, Hiromichi Tanaka, 1995 .

Activity against Human Immunodeﬁciency Virus Type 1, Intracellular Metabolism, and Effects on Human DNA Polymerases of 4 (cid:2) -Ethynyl-2-Fluoro-2 (cid:2) -Deoxyadenosine (cid:1)

Christopher M. Bailey, M. Matsuoka, H. Mitsuya, 2007 .

Potent Activity of a Nucleoside Reverse Transcriptase Inhibitor, 4′-Ethynyl-2-Fluoro-2′-Deoxyadenosine, against Human Immunodeficiency Virus Type 1 Infection in a Model Using Human Peripheral Blood Mononuclear Cell-Transplanted NOD/SCID Janus Kinase 3 Knockout Mice

H. Mitsuya, H. Hayakawa, H. Harada, 2009, Antimicrobial Agents and Chemotherapy.

2'-deoxy-4'-C-ethynyl-2-halo-adenosines active against drug-resistant human immunodeficiency virus type 1 variants.

S. Sarafianos, E. Arnold, M. Matsuoka, 2008, The international journal of biochemistry & cell biology.

Attempt to Reduce Cytotoxicity by Synthesizing the L-Enantiomer of 4′-C-Ethynyl-2′-Deoxypurine Nucleosides as Antiviral Agents against HIV and HBV

M. Matsuoka, H. Mitsuya, H. Hayakawa, 2004, Antiviral chemistry & chemotherapy.

Synthesis of 4′-C-Ethynyl and 4′-C-Cyano Purine Nucleosides from Natural Nucleosides and Their Anti-HIV Activity

M. Matsuoka, H. Mitsuya, H. Hayakawa, 2003, Nucleosides, nucleotides & nucleic acids.

Design, Efficient Synthesis, and anti-HIV Activity of 4′-C-Cyano- and 4′-C-Ethynyl-2′-deoxy Purine Nucleosides.

H. Hayakawa, 2004 .

Synthesis and antiviral activities of 1'-carbon-substituted 4'-thiothymidines.

H. Hayakawa, M. Baba, T. Nitanda, 2004, Bioorganic & medicinal chemistry.

A simple and general entry to 5-substituted uridines based on the regioselective lithiation controlled by a protecting group in the sugar moiety

H. Hayakawa, T. Miyasaka, Hiromichi Tanaka, 1987 .

A lithiation approach to cordycepin analogues variously substituted at the C-8 position

H. Hayakawa, T. Miyasaka, K. Haraguchi, 1989 .

LITHIATION-STANNYLATION CHEMISTRY OF NUCLEOSIDES

H. Hayakawa, T. Miyasaka, H. Kumamoto, 1999 .

Diethylaminosulfur Trilfluoride (DAST) as a Fluorinating Agent of Pyrimidine Nucleosides Having a 2', 3'-Vicinal Diol System

H. Hayakawa, K. Yamaguchi, T. Miyasaka, 1990 .

Dynamic aspects in the LDA lithiation of an arabinofuranosyl derivative of 4-ethoxy-2-pyrimidinone: Regioselective entry to both C-5 and C-6 substitutions

H. Hayakawa, T. Miyasaka, Hiromichi Tanaka, 1990 .

REGIOSELECTIVITY IN THE LITHIATION OF URIDINE. EFFECT OF THE SUGAR PROTECTING GROUPS

H. Hayakawa, T. Miyasaka, Hiromichi Tanaka, 1985 .

Lithiation Chemistry of Uridine Derivatives: Access to a New Anti-HIV-1 Lead

H. Hayakawa, T. Miyasaka, Hiromichi Tanaka, 1993 .

Synthesis of 6-Methyluridine via Palladium-Catalyzed Cross-Coupling Between A 6-Iodouridine Derivative and Tetramethylstannane

H. Hayakawa, T. Miyasaka, K. Haraguchi, 1992 .

Regioselectivity in the Lithiation of Uridine. Effect of the Sugar Protecting Groups.

H. Hayakawa, T. Miyasaka, Hiromichi Tanaka, 1986 .

A SIMPLIFIED SYNTHESIS OF 8-SUBSTITUTED PURINE NUCLEOSIDES VIA LITHIATION OF 6-CHLORO-9-(2, 3-O-ISOPROPYLIDENE-β-D-RIBOFURANOSYL) PURINE

A. Matsuda, H. Hayakawa, T. Miyasaka, 1983 .

“Umpulong” of reactivity at the C-6 position of uridine: a simple and general method for 6-substituted uridines

H. Hayakawa, T. Miyasaka, Hiromichi Tanaka, 1982 .

Lithiation of Uracilnucleosides and its Application to the Synthesis of a New Class of Anti-HIV-1 Acyclonucleosides

Erik De Clercq, Richard T. Walker, R. T. Walker, 1991 .

Diethylaminosulfur Trifluoride (DAST) as a Fluorinating Agent of Pyrimidine Nucleosides Having a 2′,3′-Vicinal Diol System.

H. Hayakawa, K. Yamaguchi, T. Miyasaka, 1991 .

Synthesis of 6-aroyluridine from uridine via regiospecific lithiation.

H. Hayakawa, T. Miyasaka, Hiromichi Tanaka, 1981 .

Introduction of an Azido Group to the C-6 Position of Uridine by the Use of a 6-Iodouridine Derivative

H. Hayakawa, T. Miyasaka, K. Haraguchi, 1985 .

Lithiation of 3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-deoxyuridine: synthesis of 6-substituted 2'-deoxyuridines

H. Hayakawa, T. Miyasaka, K. Haraguchi, 1985 .

Desulfurizative stannylation of uracil derivatives

H. Hayakawa, T. Miyasaka, Hiromichi Tanaka, 1985 .

The Reaction of 6-Phenylthiouridine with Sulfur Nucleophiles : A Simple and Regiospecific Preparation of 6-Alkylthiouridines and 6-Alkylthiouridylic Acids

A. Matsuda, H. Hayakawa, T. Miyasaka, 1983 .

A NOVEL AND REGIOSPECIFIC ROUTE TO 5-ACYLURIDINES VIA AN AMIDE α-ANION DERIVED FROM 5,6-DIHYDROURIDINE

H. Hayakawa, T. Miyasaka, Hiromichi Tanaka, 1982 .

A facile and regiospecific preparation of 6-alkyluridines.

H. Hayakawa, T. Miyasaka, H. Tanaka, 1980, Nucleic acids symposium series.

Lithiation-mediated CC silyl and stannyl migrations observed in 6-chloro-9-(β-d-ribofuranosyl)purine

H. Hayakawa, T. Miyasaka, H. Kumamoto, 1995 .

A SIMPLIFIED SYNTHESIS OF 8-SUBSTITUTED PURINE NUCLEOSIDES VIA LITHIATION OF 6-CHLORO-9-(2,3-O-ISOPROPYLIDENE-β-D-RIBOFURANOSYL)PURINE

A. Matsuda, H. Hayakawa, T. Miyasaka, 1983 .

A Simple and General Entry to 5-Substituted Uridines Based on the Regioselective Lithiation Controlled by a Protecting Group in the Sugar Moiety.

H. Hayakawa, T. Miyasaka, Hiromichi Tanaka, 1987 .

Synthesis of 2-Alkynylcordycepins and Evaluation of Their Vasodilating Activity

A. Matsuda, H. Hayakawa, T. Miyasaka, 1998 .

Introduction of an alkyl group into the sugar portion of uracilnucleosides by the use of gilman reagents

H. Hayakawa, T. Miyasaka, Hiromichi Tanaka, 1990 .

A Lithiation Approach to Cordycepin Analogues Variously Substituted at the C-8 Position.

H. Hayakawa, T. Miyasaka, K. Haraguchi, 1989 .

Preparation of 8-Chloropurine Nucleosides Through the Reaction Between their C-8 Lithiated Species and p-Toluenesulfonyl Chloride

H. Hayakawa, T. Miyasaka, K. Haraguchi, 1988 .

Lithiation—Stannylation Chemistry of Nucleosides

H. Hayakawa, T. Miyasaka, H. Kumamoto, 1999 .

Stereoselective Synthesis of 2-Deoxy-2-Fluoroarabinofuranosyl-α-1-Phosphate and Its Application to the Synthesis of 2′-Deoxy-2′-Fluoroarabinofuranosyl Purine Nucleosides by a Chemo-Enzymatic Method

H. Hayakawa, Kohei Yamada, N. Matsumoto, 2009, Nucleosides, nucleotides & nucleic acids.

Stereoselective Synthesis of the Chiral Tetrahydropyrane Core of Swinholides and Misakinolides

H. Hayakawa, M. Miyashita, M. Miyazawa, 1999 .

A New Entry to 2‐Substituted Purine Nucleosides Based on Lithiation‐Mediated Stannyl Transfer of 6‐Chloropurine Nucleosides.

S. Shuto, H. Hayakawa, T. Miyasaka, 1998 .