P. Vallance

P. Vallance, J. Deanfield, R. Macallister, 2001, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Vascular Nitric Oxide in Health and Disease

P. Vallance, 2000 .

Biphasic response to acetylcholine in human veins in vivo: the role of the endothelium.

P. Vallance, J. Collier, 1990, Clinical science.

Developmental Regulation of GTP-CH1 in the Porcine Lung and Its Relationship to Pulmonary Vascular Relaxation

P. Vallance, J. Leiper, M. Nandi, 2006, Pediatric Research.

Pulmonary Hypertension in a GTP-Cyclohydrolase 1–Deficient Mouse

T. Jacques, P. Vallance, S. Heales, 2005, Circulation.

Effects of a nitric oxide synthase inhibitor in humans with septic shock.

S. Moncada, P. Vallance, A. Leone, 1994, Cardiovascular research.

Renoprotective effects of renin-angiotensin-system inhibitors – Authors' reply

L. Smeeth, A. Hingorani, P. Vallance, 2006, The Lancet.

Inhibition and stimulation of nitric oxide synthesis in the human forearm arterial bed of patients with insulin-dependent diabetes.

P. Vallance, A. Calver, J. Collier, 1992, The Journal of clinical investigation.

The role of induction of nitric oxide synthesis in the altered responses of jugular veins from endotoxaemic rabbits

S. Moncada, P. Vallance, R. Palmer, 1992, British journal of pharmacology.

Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo.

P. Vallance, J. Deanfield, N. Klein, 2001, Circulation.

Asymmetric Dimethylarginine Causes Hypertension and Cardiac Dysfunction in Humans and Is Actively Metabolized by Dimethylarginine Dimethylaminohydrolase

P. Vallance, J. Leiper, R. Macallister, 2003, Arteriosclerosis, thrombosis, and vascular biology.

Periodontal therapy: a novel non-drug-induced experimental model to study human inflammation.

P. Vallance, V. Mohamed-ali, M. Tonetti, 2004, Journal of periodontal research.

Effect of local inhibition of nitric oxide synthesis on forearm blood flow and dorsal hand vein size in patients with alcoholic cirrhosis.

P. Vallance, A. Calver, J. Maxwell, 1994, Clinical science.

Effects of guanidino and uremic compounds on nitric oxide pathways.

P. Vallance, R. Macallister, G. Whitley, 1994, Kidney international.

Regulation of the ADMA-DDAH system in endothelial cells: a novel mechanism for the sterol response element binding proteins, SREBP1c and -2.

Z. Ao, D. Johns, P. Vallance, 2010, American journal of physiology. Heart and circulatory physiology.

The DDAH/ADMA/NOS pathway.

P. Vallance, J. Leiper, C. Tran, 2003, Atherosclerosis. Supplements.

Protease-Activated Receptor 2–Mediated Vasodilatation in Humans In Vivo: Role of Nitric Oxide and Prostanoids

P. Vallance, R. Kharbanda, P. Mclean, 2003, Circulation.

Endothelium‐dependent sensory NANC vasodilatation: involvement of ATP, CGRP and a possible NO store

P. Vallance, A. Ahluwalia, M. Kakuyama, 1998, British journal of pharmacology.

Endothelial Nitric Oxide Gene Haplotypes and Risk of Cerebral Small-Vessel Disease

P. Sham, M. O’Sullivan, H. Markus, 2004, Stroke.

Endothelial dysfunction and raised plasma concentrations of asymmetric dimethylarginine in pregnant women who subsequently develop pre-eclampsia

A. Hingorani, K. Nicolaides, P. Vallance, 2003, The Lancet.

Effect of local intra-arterial NG-monomethyl-L-arginine in patients with hypertension: the nitric oxide dilator mechanism appears abnormal.

S. Moncada, P. Vallance, A. Calver, 1992, Journal of hypertension.

ESH/ESC guidelines.

P. Vallance, B. Prichard, 2004, Journal of hypertension.

Genetic and Environmental Determinants of Plasma Nitrogen Oxides and Risk of Ischemic Heart Disease

A. Hingorani, P. Vallance, G. Miller, 2001, Hypertension.

Effects of cytokines on nitric oxide pathways in human vasculature.

P. Vallance, K. Bhagat, 1999, Current opinion in nephrology and hypertension.

Nitric oxide and vascular responses in Type I diabetes

P. Vallance, H. Colhoun, N. Chan, 2000, Diabetologia.

ADMA regulates angiogenesis: genetic and metabolic evidence

C. Heeschen, P. Vallance, M. Kimoto, 2005, Vascular medicine.

Asymmetric dimethylarginine (ADMA): a key regulator of nitric oxide synthase.

J. Cooke, P. Vallance, R. Böger, 2003, Atherosclerosis. Supplements.

Endogenous Dimethylarginine as an Inhibitor of Nitric Oxide Synthesis

S. Moncada, P. Vallance, A. Leone, 1992, Journal of cardiovascular pharmacology.

Synthesis of NG, NG Dimethylarginine by Human Endothelial Cells

S. Nussey, P. Vallance, A. Leone, 1993 .

Concentration of dimethyl-L-arginine in the plasma of patients with end-stage renal failure

P. Vallance, M. Rambausek, E. Ritz, 1996 .

Nitric Oxide and Hypertension: Physiology and Pathophysiology

S. Moncada, P. Vallance, 1997 .

Endogenous Inhibitors of Nitric Oxide Synthesis:How Important Are They?

P. Vallance, R. Macallister, 1998, Nephron Experimental Nephrology.

Nitric oxide-mediated vasodilation in human pregnancy.

P. Vallance, D. Williams, F. Imms, 1997, The American journal of physiology.

Measurement of nitrite and nitrate levels in plasma and urine--what does this measure tell us about the activity of the endogenous nitric oxide system?

P. Vallance, C. Baylis, 1998, Current opinion in nephrology and hypertension.

An Endothelium-Derived Hyperpolarizing Factor–Like Factor Moderates Myogenic Constriction of Mesenteric Resistance Arteries in the Absence of Endothelial Nitric Oxide Synthase–Derived Nitric Oxide

P. Vallance, A. Ahluwalia, S. Chauhan, 2001, Hypertension.

Amrita Ahluwalia Derived Nitric Oxide − Synthase Constriction of Mesenteric Resistance Arteries in the Absence of Endothelial Nitric Oxide Like Factor Moderates Myogenic − An Endothelium-Derived Hyperpolarizing Factor

P. Vallance, S. Chauhan, 2001 .

Endogenous factors involved in regulation of tone of arterial vasa vasorum: implications for conduit vessel physiology.

P. Vallance, A. Ahluwalia, R. Scotland, 2000, Cardiovascular research.

Endothelin receptors mediating functional responses in human small arteries and veins

P. Vallance, J. Riezebos, P. Vallance, 1994, British journal of pharmacology.

Endothelin alters the reactivity of vasa vasorum: mechanisms and implications for conduit vessel physiology and pathophysiology

P. Vallance, A. Ahluwalia, P. Vallance, 1999, British journal of pharmacology.

all-trans-Retinoic Acid Increases Nitric Oxide Synthesis by Endothelial Cells: A Role for the Induction of Dimethylarginine Dimethylaminohydrolase

P. Vallance, J. Leiper, G. Whitley, 2002, Circulation research.

The interplay between platelet and vessel-wall mediators in coronary artery occlusion.

P. Vallance, 1989, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Dilator actions of arginine in human peripheral vasculature.

P. Vallance, A. Calver, J. Collier, 1991, Clinical science.

Dose- and time-dependency of the dilator effects of the endothelin antagonist, BQ-123, in the human forearm.

P. Vallance, R. Macallister, K. Bhagat, 2003, British journal of clinical pharmacology.

Human saphenous vein contains both endothelin ETA and ETB contractile receptors.

P. Vallance, M. J. Sumner, J. Mundin, 1994, European journal of pharmacology.

Vasodilatation to arachidonic acid in humans. An insight into endogenous prostanoids and effects of aspirin.

P. Vallance, J. Collier, K. Bhagat, 1995, Circulation.

Positive inotropic effects of NO donors in isolated guinea-pig and human cardiomyocytes independent of NO species and cyclic nucleotides.

P. Vallance, S. Harding, D. Sarkar, 2000, Cardiovascular research.

Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases.

Ian G. Charles, I. Charles, P. Vallance, 1999, The Biochemical journal.

Importance of asymmetrical dimethylarginine in cardiovascular risk

P. Vallance, 2001, The Lancet.

Local L-NG-monomethyl-arginine attenuates the vasodilator action of bradykinin in the human forearm.

D. Webb, P. Vallance, K. P. O'kane, 1994, British journal of clinical pharmacology.

Cholinergic contraction is altered in nNOS knockouts. Cooperative modulation of neural bronchoconstriction by nNOS and COX.

P. Vallance, A. Ahluwalia, M. Kakuyama, 1999, American journal of respiratory and critical care medicine.

Coronary artery disease—from bench to bedside

P. Vallance, P. Vallance, R. Kharbanda, 2001, Journal of the Royal Society of Medicine.

Permeability Changes in the Human Endothelial Cell Line, SGHEC-7, Caused by IL-1β, TNFα and Substance P

P. Vallance, G. Whitley, H. Parry, 1996 .

Immunolocalisation and activity of DDAH I and II in the heart and modification post-myocardial infarction.

P. Vallance, Alison Wallace, J. Leiper, 2010, Acta histochemica.

Nitric oxide: not just a negative inotrope

P. Vallance, S. Harding, D. Sarkar, 2001, European journal of heart failure.

Role of thromboxane A2 in the vasoconstrictor response to endothelin-1, angiotensin II and 5-hydroxytryptamine in human placental vessels.

P. Vallance, C. Wilson, S. R. Howarth, 1995, Placenta.

Role of endogenous nitric oxide in septic shock.

S. Moncada, P. Vallance, 1993, New horizons.

Nitric oxide in the human cardiovascular system--SKB lecture 1997.

P. Vallance, Patrick Vallance, 1998, British journal of clinical pharmacology.

Therapeutic Potential of NOS Inhibitors in Septic Shock

S. Moncada, P. Vallance, D. Rees, 2000 .

A post-take ward round.

P. Vallance, 2005, Journal of the Royal Society of Medicine.

The effect of endothelium-derived nitric oxide on ex vivo whole blood platelet aggregation in man

P. Vallance, J. Collier, N. Benjamin, 2004, European Journal of Clinical Pharmacology.

Endothelial Nitric Oxide Synthase Gene Polymorphism and Maternal Vascular Adaptation to Pregnancy

A. Hingorani, K. Nicolaides, P. Vallance, 2001, Hypertension.

Exploring Vascular Nitric Oxide in Health and Disease

P. Vallance, 1997, Journal of the Royal College of Physicians of London.

Over-expression of GTP-cyclohydrolase 1 feedback regulatory protein attenuates LPS and cytokine-stimulated nitric oxide production

P. Vallance, J. Leiper, M. Nandi, 2008, Vascular medicine.

Cytokine-induced venodilatation in humans in vivo: eNOS masquerading as iNOS.

A. Hingorani, P. Vallance, K. Bhagat, 1999, Cardiovascular Research.

Human Cytomegalovirus Seropositivity Is Associated With Impaired Vascular Function

G. Ridgway, P. Vallance, V. Emery, 2003, Circulation.

Hyperdynamic circulation in cirrhosis: a role for nitric oxide?

S. Moncada, P. Vallance, P. Vallance, 1991, The Lancet.

S-nitroso-albumin carries a thiol-labile pool of nitric oxide, which causes venodilation in the rat.

Dean P. Jones, P. Vallance, K. Moore, 2005, American journal of physiology. Heart and circulatory physiology.

Intracellular localization of dimethylarginine dimethylaminohydrolase overexpressed in an endothelial cell line.

P. Vallance, J. Leiper, G. Birdsey, 2000, Acta physiologica Scandinavica.

Nitric Oxide in Sepsis: Of Mice and Men

I. Charles, P. Vallance, 1998 .

Inducible nitric oxide synthase in the cardiovascular system.

P. Vallance, K. Bhagat, 1996, Heart.

Functional effects ofeconazole on inducible nitric oxide synthase: production ofacalmodulin-dependent enzyme

P. Vallance, 1996 .

Evidence for functional responses to sensory nerve stimulation of rat small mesenteric veins.

P. Vallance, A. Ahluwalia, 1997, The Journal of pharmacology and experimental therapeutics.

Enhanced Atherogenesis Is Not an Obligatory Response to Systemic Herpesvirus Infection in the ApoE-Deficient Mouse: Comparison of Murine &ggr;-Herpesvirus-68 and Herpes Simplex Virus-1

P. Vallance, K. Powell, D. Alber, 2002, Arteriosclerosis, thrombosis, and vascular biology.

Nitric oxide as an antimicrobial agent: does NO always mean NO?

I. Charles, P. Vallance, 1998, Gut.

Deletion of the eNOS gene has a greater impact on the pulmonary circulation of male than female mice.

P. Vallance, A. Hislop, S. Haworth, 2005, American journal of physiology. Lung cellular and molecular physiology.

pulmonary circulation of male than female mice Deletion of the eNOS gene has a greater impact on the

P. Vallance, A. Hislop, S. Haworth, 2005 .

The effect of malnutrition on cardiovascular mortality in dialysis patients: is L-arginine the answer?

P. Vallance, E. Ritz, M. Nowicki, 1994, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Vascular Endothelium in Human Physiology and Pathophysiology

D. Webb, P. Vallance, 2000 .

Effect of local intra-arterial asymmetric dimethylarginine (ADMA) on the forearm arteriolar bed of healthy volunteers.

S. Moncada, P. Vallance, A. Leone, 1993, Journal of human hypertension.

Common genetic variation in a basal promoter element alters DDAH2 expression in endothelial cells.

A. Hingorani, P. Vallance, J. Leiper, 2003, Biochemical and biophysical research communications.

Isoform-Specific Regulation by NG,NG-Dimethylarginine Dimethylaminohydrolase of Rat Serum Asymmetric Dimethylarginine and Vascular Endothelium-Derived Relaxing Factor/NO

Maristela L Onozato, M. Onozato, P. Vallance, 2007, Circulation research.

Effect of inhibitors of the renin-angiotensin system and other antihypertensive drugs on renal outcomes: systematic review and meta-analysis

L. Smeeth, A. Hingorani, P. Vallance, 2005, The Lancet.

On the regulation of tone in vasa vasorum.

P. Vallance, A. Ahluwalia, R. Scotland, 1999, Cardiovascular research.

Plasma concentrations of endogenous inhibitor of nitric oxide synthesis in normal pregnancy and pre-eclampsia

S. Nussey, P. Vallance, G. Whitley, 1993, The Lancet.

The vascular endothelium in diabetes and hypertension.

P. Vallance, A. Calver, J. Collier, 1992, Journal of hypertension. Supplement : official journal of the International Society of Hypertension.

Chromosomal localization, gene structure, and expression pattern of DDAH1: comparison with DDAH2 and implications for evolutionary origins.

M. Fox, P. Vallance, J. Leiper, 2000, Genomics.

Prevention of Inflammation-Induced Endothelial Dysfunction: A Novel Vasculo-Protective Action of Aspirin

A. Hingorani, P. Vallance, N. Klein, 2002, Circulation.

Endothelial function: 20 years of clinical investigation

P. Vallance, 2005, Heart.

Vascular and hormonal responses to arginine: provision of substrate for nitric oxide or non-specific effect?

P. Vallance, C. Edwards, R. Macallister, 1995, Clinical science.

Metabolism of Asymmetric Dimethylarginines Is Regulated in the Lung Developmentally and With Pulmonary Hypertension Induced by Hypobaric Hypoxia

P. Vallance, J. Leiper, S. Haworth, 2003, Circulation.

Association between Kaposi's sarcoma and atherosclerosis: implications for gammaherpesviruses and vascular disease.

P. Vallance, S. Lucas, R. Miller, 2001, AIDS.

Use of L-arginine and its analogs to study nitric oxide pathway in humans.

P. Vallance, Patrick Vallance, 1996, Methods in enzymology.

The potassium channel opening drug cromakalim produces arterioselective vasodilation in the upper limbs of healthy volunteers.

D. Webb, P. Vallance, N. Benjamin, 1989, British journal of clinical pharmacology.

EFFECTS OF ENDOTHELIUM-DERIVED NITRIC OXIDE ON PERIPHERAL ARTERIOLAR TONE IN MAN

S. Moncada, P. Vallance, J. Collier, 1989, The Lancet.

Investigation of vascular mechanisms: bridging the gap between basic research and clinical trials.

P. Vallance, J. Collier, 1993, Trends in pharmacological sciences.

The ADMA/DDAH pathway is a critical regulator of endothelial cell motility

P. Vallance, B. Fisslthaler, I. Fleming, 2007, Journal of Cell Science.

Comment: the asymmetrical dimethylarginine/dimethylarginine dimethylaminohydrolase pathway in the regulation of nitric oxide generation.

P. Vallance, 2001, Clinical science.

Elevated C‐reactive protein and pro‐inflammatory cytokines in Andean women with pre‐eclampsia

P. López-Jaramillo, P. Vallance, E. Terán, 2001, International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics.

Use of Nitric Oxide Synthase Inhibitors in Septic Shock

P. Vallance, P. Vallance, 1994 .

Colocalization of demethylating enzymes and NOS and functional effects of methylarginines in rat kidney.

P. Vallance, W. Welch, M. Omata, 1997, Kidney international.

Inhibition of dimethylarginine dimethylaminohydrolase (DDAH) and arginine deiminase (ADI) by pentafluorophenyl (PFP) sulfonates.

Jonathan D. Wilden, P. Vallance, S. Caddick, 2005, Chemical communications.

Forearm blood flow responses to a nitric oxide synthase inhibitor in patients with treated essential hypertension.

P. Vallance, A. Calver, J. Collier, 1994, Cardiovascular research.

Endothelium‐derived relaxing factor is an endogenous vasodilator in man

P. Vallance, J. Collier, 1989, British journal of pharmacology.

Inflammation and Endothelial Function: Direct Vascular Effects of Human C-Reactive Protein on Nitric Oxide Bioavailability

M. Singer, A. Hingorani, P. Vallance, 2005, Circulation.

Enhancement of endothelium-dependent vasodilatation by oestradiol 17-beta: Role of the pterin pathway

A. Hingorani, P. Vallance, A. Ahluwalia, 1999 .

Cardiovascular risk factors as determinants of endothelium-dependent and endothelium-independent vascular reactivity in the general population.

P. Vallance, H. Colhoun, N. Chan, 2001, Journal of the American College of Cardiology.

Endothelial function and nitric oxide: clinical relevance

P. Vallance, N. Chan, 2001, Heart.

Heterogenous Nature of Flow-Mediated Dilatation in Human Conduit Arteries In Vivo: Relevance to Endothelial Dysfunction in Hypercholesterolemia

P Vallance, P. Vallance, J. Deanfield, 2001, Circulation research.

Acute Systemic Inflammation Impairs Endothelium-Dependent Dilatation in Humans

Aroon D. Hingorani, Rajesh K. Kharbanda, A. Hingorani, 1999, Circulation.

Nitric oxide and arginine.

P. Vallance, 1999, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

Inflammatory cytokines impair endothelium-dependent dilatation in human veins in vivo.

P. Vallance, K. Bhagat, P. Vallance, 1997, Circulation.

Infection, inflammation, and infarction: does acute endothelial dysfunction provide a link?

P. Vallance, J. Collier, K. Bhagat, 1997, The Lancet.

Nitric Oxide 9 Years On

P. Vallance, P. Vallance, K. Bhagat, 1996, Journal of the Royal Society of Medicine.

Carriage of the V279F Null Allele within the Gene Encoding Lp-PLA2 Is Protective from Coronary Artery Disease in South Korean Males

L. Cardon, J. Whittaker, B. Han, 2011, PloS one.

New tricks from an old dog: nitric oxide-independent effects of dimethylarginine dimethylaminohydrolase.

James Leiper, P. Vallance, J. Leiper, 2006, Arteriosclerosis, thrombosis, and vascular biology.

What is the optimal age for starting lipid lowering treatment? A mathematical model

A. Hingorani, P. Vallance, Aroon D Hingorani, 2000, BMJ : British Medical Journal.

Functional effects of econazole on inducible nitric oxide synthase: production of a calmodulin‐dependent enzyme

P. Vallance, R. Bogle, 1996, British journal of pharmacology.

Effect of anti‐fungal imidazoles on mRNA levels and enzyme activity of inducible nitric oxide synthase

P. Vallance, S. Soo, G. Whitley, 1994, British journal of pharmacology.

Induction of NG-monomethyl-L-arginine uptake: a mechanism for differential inhibition of NO synthases?

P. Vallance, R. Macallister, G. Whitley, 1995, The American journal of physiology.

Drugs and the fetus

P. Vallance, 1996, BMJ.

Nitric oxide and cardiovascular control

P. Vallance, A. Calver, J. Collier, 1993, Experimental physiology.

Tyrosine nitration in blood vessels occurs with increasing nitric oxide concentration

P. Vallance, P. Vallance, R. Bogle, 1999, British journal of pharmacology.

Physiological importance of nitric oxide.

P. Vallance, J. Collier, 1991, BMJ.

Disruption of methylarginine metabolism impairs vascular homeostasis

P. Vallance, J. Murray-Rust, N. McDonald, 2007, Nature Medicine.

Dimethylarginine Dimethylaminohydrolase Regulates Nitric Oxide Synthesis: Genetic and Physiological Evidence

P. Tsao, J. Cooke, P. Vallance, 2003, Circulation.

Biological significance of endogenous methylarginines that inhibit nitric oxide synthases.

P. Vallance, J. Leiper, P. Vallance, 1999, Cardiovascular research.

Inflammation-induced endothelial dysfunction involves reduced nitric oxide bioavailability and increased oxidant stress.

Rajesh K Kharbanda, A. Hingorani, P. Vallance, 2004, Cardiovascular research.

Second messenger role for NO widens to nervous and immune systems.

P. Vallance, J. Collier, 1989, Trends in pharmacological sciences.

Industry-Academic Relationship in a New Era of Drug Discovery.

P. Vallance, 2016, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Nitric oxide synthesised from L-arginine mediates endothelium dependent dilatation in human veins in vivo.

P Vallance, S. Moncada, P. Vallance, 1989, Cardiovascular research.

Nitric oxide: an endogenous gas.

P. Vallance, A. Petros, A. Quinn, 1995, British journal of anaesthesia.

Endothelial "stunning" following a brief exposure to endotoxin: a mechanism to link infection and infarction?

P. Vallance, J. Collier, K. Bhagat, 1996, Cardiovascular research.

Four principles to make evidence synthesis more useful for policy

C. Donnelly, C. Whitty, M. Walport, 2018, Nature.

Structural insights into the hydrolysis of cellular nitric oxide synthase inhibitors by dimethylarginine dimethylaminohydrolase

P. Vallance, J. Murray-Rust, Sarah J. Tilley, 2001, Nature Structural Biology.

Endothelium-Dependent and -Independent Vascular Dysfunction in Type 1 Diabetes: Role of Conventional Risk Factors, Sex, and Glycemic Control

P. Vallance, H. Colhoun, N. Chan, 2003, Arteriosclerosis, thrombosis, and vascular biology.

Dimethylaminohydrolase New Tricks From an Old Dog : Nitric Oxide-Independent Effects of Dimethylarginine

P. Vallance, J. Leiper, 2013 .

Nitric Oxide–Independent Effects of Dimethylarginine Dimethylaminohydrolase

P. Vallance, J. Leiper, 2006 .

Asymmetric dimethylarginine and kidney disease--marker or mediator?

P. Vallance, J. Leiper, 2005, Journal of the American Society of Nephrology : JASN.

Concentration of dimethyl-L-arginine in the plasma of patients with end-stage renal failure.

P. Vallance, M. Rambausek, E. Ritz, 1996, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Chronic Stress Accelerates Atherosclerosis in the Apolipoprotein E Deficient Mouse

M. Marmot, S. Lightman, M. Kumari, 2003, Stress.

Herpesvirus infection accelerates atherosclerosis in the apolipoprotein E-deficient mouse.

P. Vallance, K. Powell, P. Vallance, 2000, Circulation.

Nitric oxide: therapeutic opportunities

P. Vallance, 2003, Fundamental & clinical pharmacology.

Cardiovascular Biology of the Asymmetric Dimethylarginine:Dimethylarginine Dimethylaminohydrolase Pathway

P. Vallance, J. Leiper, 2004, Arteriosclerosis, thrombosis, and vascular biology.

Endothelial NO Synthase Genotype and Risk of Preeclampsia: A Multicenter Case-Control Study

P. López-Jaramillo, E. Hawe, A. Hingorani, 2004, Hypertension.

Fortnightly Review Biology and clinical relevance of nitric oxide

P. Vallance, J. Collier, Patrick Vallance, 1994, BMJ.

Epidemiological trends of head and neck Cancer survivors in Alberta: towards improved understanding of the burden of disease

V. Biron, P. Vallance, C. Jeffery, 2020, Journal of Otolaryngology - Head & Neck Surgery.

Epidemiological trends of head and neck cancer survivors in Alberta: Towards improved understanding of the burden of disease.

P. Vallance, C. Jeffery, 2018 .

Cardiovascular tests: use & limits of biochemical markers - therapeutic measurements of ADMA involved in cardiovascular disorders.

P. Vallance, Caroline L. Smith, Caroline L. Smith, 2005, Current pharmaceutical design.

Seeking a role for the clinical pharmacologist.

P. Vallance, 1991, Trends in pharmacological sciences.

Measuring forearm blood flow and interpreting the responses to drugs and mediators.

P Vallance, D. Webb, P. Vallance, 1995, Hypertension.

Endothelial Function in Hypertension

D. Webb, P. Vallance, 1997, Springer Berlin Heidelberg.

Regulation of nitric oxide synthesis by dimethylarginine dimethylaminohydrolase

P. Vallance, M. Kimoto, R. Macallister, 1996, British journal of pharmacology.

Flow associated or flow mediated dilatation? More than just semantics.

K Bhagat, A Hingorani, P Vallance, 1997, Heart.

Effects of S-nitroso-glutathione in the human forearm circulation: evidence for selective inhibition of platelet activation.

S. Moncada, P. Vallance, M. Radomski, 1994, Cardiovascular research.

Discovery of inhibitors of the pentein superfamily protein dimethylarginine dimethylaminohydrolase (DDAH), by virtual screening and hit analysis.

P. Vallance, P. Gane, J. Leiper, 2007, Bioorganic & medicinal chemistry letters.

The Journal of Clinical Endocrinology & Metabolism Printed in U.S.A. Copyright © 2001 by The Endocrine Society Changes in Endothelium-Dependent Vasodilatation and �-Adrenergic Responses in Resistance Vessels during the Menstrual Cycle in Healthy Women*

A. Hingorani, P. Vallance, H. Colhoun, 2022 .

Differential Effect of Three Cyclooxygenase Inhibitors on Human Cerebral Blood Flow Velocity and Carbon Dioxide Reactivity

H. Markus, P. Vallance, M. Brown, 1994, Stroke.

S-nitrosylation of dimethylarginine dimethylaminohydrolase regulates enzyme activity: Further interactions between nitric oxide synthase and dimethylarginine dimethylaminohydrolase

P. Vallance, J. Murray-Rust, N. McDonald, 2002, Proceedings of the National Academy of Sciences of the United States of America.

The Effect of the Nitric Oxide Synthase Inhibitor L-NMMA on Basal CBF and Vasoneuronal Coupling in Man: A PET Study

Richard P. White, D. Brooks, V. Cunningham, 1999, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Nitric oxide synthase inhibition in humans reduces cerebral blood flow but not the hyperemic response to hypercapnia.

Richard P. White, H S Markus, P Vallance, 1998, Stroke.

Asymmetric Dimethylarginine in Cerebral Small Vessel Disease

H. Markus, P. Vallance, Ahamad Hassan, 2007, Stroke.

The future of pharmacology

P. Vallance, T. Smart, 2006, British journal of pharmacology.

Effect of acute plasma volume expansion on peripheral arteriolar tone in healthy subjects.

P. Vallance, A. Calver, J. Collier, 1992, Clinical science.

The effects of hormone replacement therapy on endothelial function in women with Turner’s syndrome

A. Hingorani, P. Vallance, G. Conway, 2002, Clinical endocrinology.

Platelet adhesion to human vascular endothelium is modulated by constitutive and cytokine induced nitric oxide.

S. Moncada, P. Vallance, M. Radomski, 1993, Cardiovascular research.

A role for Dimethylarginine Dimethylaminohydrolase 1 (DDAH1) in mammalian development.

Manasi Nandi, Ross A Breckenridge, Peter Kelly, 2010, The International journal of developmental biology.

Regulation of GTP Cyclohydrolase I by Estrogen

A. Hingorani, P. Vallance, A. Ahluwalia, 2002 .

Increasing dimethylarginine levels are associated with adverse clinical outcome in severe alcoholic hepatitis

Roger Williams, P. Vallance, R. Jalan, 2007, Hepatology.

Nitric oxide in essential and renal hypertension.

P. Vallance, R. Macallister, 1994, Journal of the American Society of Nephrology : JASN.

The synthesis and metabolism of asymmetric dimethylarginine (ADMA)

P. Vallance, J. Leiper, 2006, European Journal of Clinical Pharmacology.

Effects of ADMA upon gene expression : an insight into the pathophysiological significance of raised plasma ADMA

M. Hubank, P. Vallance, J. Leiper, 2005 .

Endothelial nitric oxide in humans in health and disease

A. Hingorani, P. Vallance, 1999, International journal of experimental pathology.

Endogenous inhibitors of nitric oxide synthesis: How important are they?

P. Vallance, J. Leiper, M. Nandi, 2006 .

Dietary nitrate: poison or panacea?

P. Vallance, 1997, Gut.

Dietary nitrate: poison or panacea? [comment]

P. Vallance, 1997 .

Direct measurement of nitric oxide in human beings

S. Moncada, P. Vallance, M. Radomski, 1995, The Lancet.

Nephrology Dialysis Transplantation Concentration of dimethyl-L-arginine in the plasma of patients with end-stage renal failure

P. Vallance, M. Rambausek, E. Ritz, 2005 .

Nitric oxide and blood pressure: effects of nitric oxide deficiency

P. Vallance, C. Baylis, 1996, Current opinion in nephrology and hypertension.

Biochemical characterization of S-nitrosohemoglobin. Mechanisms underlying synthesis, no release, and biological activity.

M. Wolzt, S. Moncada, P. Vallance, 1999, The Journal of biological chemistry.

Effect of diadenosine phosphates on human umbilical vessels: novel platelet-derived vasoconstrictors.

P. Vallance, R. Macallister, R. Bogle, 1995, British journal of clinical pharmacology.

Regulation of macrophage nitric oxide synthesis by endothelial cells: a role for NG,NG-dimethylarginine.

S. Nussey, P. Vallance, Judith E. Cartwright, 1999, Acta physiologica Scandinavica.

Identification of microbial dimethylarginine dimethylaminohydrolase enzymes.

I. Charles, P. Vallance, J. Leiper, 1999, Molecular microbiology.

Nitric oxide and blood vessels: Physiological role and clinical implications

P. Vallance, A. Calver, J. Collier, 1992 .

Systemic vascular adaptation to increases in blood volume: the role of the blood-vessel wall.

P. Vallance, R. Macallister, 1996, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Nitric Oxide - From Mediator to Medicines

S. Moncada, P. Vallance, 1994, Journal of the Royal College of Physicians of London.

Nitric oxide and the control of human vascular tone in health and disease.

P. Vallance, A. Calver, J. Collier, 1993, The European journal of medicine.

Effects of Endotoxin on Endothelium-Dependent and -Independent Responses in the Isolated Rat Heart

P. Vallance, R. Bogle, 1998 .

MicroCorrespondence: Identification of microbial dimethylarginine dimethylaminohydrolase enzymes

I. Charles, P. Vallance, J. Leiper, 1999 .

Separate R&D budget is needed for monitoring effects of new drugs

P. Vallance, 1998, BMJ.

Metabolism ofmethylarginines byhumanvasculature; implications fortheregulation ofnitric oxide synthesis

P. Vallance, 1994 .