K. Machida

发表

Hepatitis C virus infects T cells and affects interferon-γ signaling in T cell lines

M. Lai, Y. Kondo, V. M. Sung, 2007 .

Association of Hepatitis C Virus Replication Complexes with Microtubules and Actin Filaments Is Dependent on the Interaction of NS3 and NS5A

M. Lai, K. Machida, K. Jeng, 2008, Journal of Virology.

Isolation of RNA aptamers specific to the NS3 protein of hepatitis C virus from a pool of completely random RNA.

K. Machida, P. Urvil, K. Shimotohno, 1997, Virology.

Alcohol and hepatitis C virus--interactions in immune dysfunctions and liver damage.

K. Machida, J. Wands, G. Szabo, 2010, Alcoholism, clinical and experimental research.

Mouse intragastric infusion (iG) model

K. Machida, H. Tsukamoto, Akiko Ueno, 2012, Nature Protocols.

Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis.

K. Machida, M. Martínez-Chantar, N. Kaplowitz, 2012, Journal of hepatology.

NUMB phosphorylation destabilizes p53 and promotes self‐renewal of tumor‐initiating cells by a NANOG‐dependent mechanism in liver cancer

H. Tokumitsu, K. Machida, V. Punj, 2015, Hepatology.

State of the art treatment of hepatitis B virus hepatocellular carcinoma and the role of hepatitis B surface antigen post‐liver transplantation and resection

K. Machida, D. Samuel, A. Vogel, 2021, Liver international : official journal of the International Association for the Study of the Liver.

Smad7 regulates compensatory hepatocyte proliferation in damaged mouse liver and positively relates to better clinical outcome in human hepatocellular carcinoma.

C. Meyer, S. Dooley, H. Allgayer, 2015, Clinical science.

Ethanol Augments RANTES/CCL5 Expression in Rat Liver Sinusoidal Endothelial Cells and Human Endothelial Cells via Activation of NF-κB, HIF-1α, and AP-11

K. Machida, H. Tsukamoto, V. Kalra, 2009, The Journal of Immunology.

HIF-1 κ Cells via Activation of NF-Endothelial Cells and Human Endothelial Expression in Rat Liver Sinusoidal Ethanol Augments RANTES / CCL 5

K. Machida, H. Tsukamoto, V. Kalra, 2009 .

Hepatitis C virus NS3/4A protein interacts with ATM, impairs DNA repair and enhances sensitivity to ionizing radiation.

M. Lai, K. Machida, K. Jeng, 2008, Virology.

Replication of Hepatitis C Virus RNA on Autophagosomal Membranes*

E. Huang, K. Machida, Jae U. Jung, 2012, The Journal of Biological Chemistry.

Immunotherapy and Microbiota for Targeting of Liver Tumor-Initiating Stem-like Cells

K. Machida, S. Tahara, 2022, Cancers.

TLR4 Signaling via NANOG Cooperates With STAT3 to Activate Twist1 and Promote Formation of Tumor-Initiating Stem-Like Cells in Livers of Mice.

B. Naini, A. Zarrinpar, K. Machida, 2016, Gastroenterology.

Title TLR 4 Signaling via NANOG Cooperates with STAT 3 to Activate Twist 1 and Promote Formation of Tumor-Initiating Stem-Like Cells in Livers of Mice Permalink

B. Naini, A. Zarrinpar, K. Machida, 2016 .

Osteopontin deficiency does not prevent but promotes alcoholic neutrophilic hepatitis in mice

K. Machida, H. Tsukamoto, Raymond P. Wu, 2015, Hepatology.

GRP78 binds SARS-CoV-2 Spike protein and ACE2 and GRP78 depleting antibody blocks viral entry and infection in vitro

K. Machida, Amy S. Lee, P. Gill, 2021, bioRxiv.

Alcohol Induces RNA Polymerase III-dependent Transcription through c-Jun by Co-regulating TATA-binding Protein (TBP) and Brf1 Expression*

K. Machida, Deborah L. Johnson, H. Tsukamoto, 2010, The Journal of Biological Chemistry.

The TBC1D15 Oncoprotein Controls Stem Cell Self-Renewal through Destabilization of the Numb-p53 Complex

K. Machida, V. Punj, D. Feldman, 2013, PloS one.

Ethanol-induced HO-1 and NQO1 Are Differentially Regulated by HIF-1α and Nrf2 to Attenuate Inflammatory Cytokine Expression*

K. Machida, V. Kalra, S. Yeligar, 2010, The Journal of Biological Chemistry.

Existence of cancer stem cells in hepatocellular carcinoma: myth or reality?

K. Machida, 2017, Hepatology International.

Wnt/β-catenin activation and macrophage induction during liver cancer development following steatosis

M. Kahn, Lei He, K. Machida, 2017, Oncogene.

Hepatitis C Virus Triggers Mitochondrial Permeability Transition with Production of Reactive Oxygen Species, Leading to DNA Damage and STAT3 Activation

M. Lai, V. M. Sung, K. Machida, 2006, Journal of Virology.

Hepatitis C Virus Triggers Mitochondrial Permeability Transition with Production of Reactive Oxygen Species , Leading to DNA Damage and STAT 3 Activation

M. Lai, V. M. Sung, K. Machida, 2006 .

Hepatitis C Virus-Related Lymphomagenesis in a Mouse Model

K. Machida, M. Kohara, K. Tsukiyama-Kohara, 2011, ISRN hematology.

A Super TLR Agonist to Improve Efficacy of Dendritic Cell Vaccine in Induction of Anti-HCV Immunity

K. Machida, Xiao-tong Song, Bangxing Hong, 2012, PloS one.

NANOG Metabolically Reprograms Tumor-Initiating Stem-like Cells through Tumorigenic Changes in Oxidative Phosphorylation and Fatty Acid Metabolism.

K. Machida, S. Hess, S. Tahara, 2016, Cell metabolism.

HCV and tumor-initiating stem-like cells

K. Machida, 2022, Frontiers in Physiology.

SYNCRIP (synaptotagmin-binding, cytoplasmic RNA-interacting protein) is a host factor involved in hepatitis C virus RNA replication

M. Lai, K. Machida, H. Aizaki, 2009, Virology.

DNMT and EZH2 inhibitors synergize to activate therapeutic targets in hepatocellular carcinoma.

D. Weisenberger, H. Lenz, K. Machida, 2022, Cancer letters.

Activated and nonactivated MSCs increase survival in humanized mice after acute liver injury through alcohol binging

K. Machida, H. Choi, M. Thornton, 2022, Hepatology communications.

Nitrogen Species and by Interfering with the Repair through Reactive Oxygen and Hepatitis C Virus Inhibits DNA Damage

M. Lai, K. Machida, G. McNamara, 2010 .

c-JUN inhibits mTORC2 and glucose uptake to promote self-renewal and obesity

Xiaohang Zhan, R. Ray, K. Machida, 2022, iScience.

p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs

R. Ray, K. Machida, H. Choi, 2020, Nature Communications.

The stress-inducible ER chaperone GRP78/BiP is upregulated during SARS-CoV-2 infection and acts as a pro-viral protein

K. Machida, Amy S. Lee, Woo-Jin Shin, 2022, Nature Communications.

The chaperone GRP78 is a host auxiliary factor for SARS-CoV-2 and GRP78 depleting antibody blocks viral entry and infection

K. Machida, Amy S. Lee, Pu Zhang, 2021, Journal of Biological Chemistry.

Toll-Like Receptor Signaling in Liver Diseases

K. Machida, T. Billiar, G. Szabo, 2011, Gastroenterology Research and Practice.

Necrostatin-1 protects against reactive oxygen species (ROS)-induced hepatotoxicity in acetaminophen-induced acute liver failure

K. Iwaisako, K. Machida, E. Hatano, 2014, FEBS open bio.

The 2-oxoglutarate carrier promotes liver cancer by sustaining mitochondrial GSH despite cholesterol loading

K. Machida, J. Montero, N. Kaplowitz, 2017, Redox biology.

Hepatitis C Virus Causes Uncoupling of Mitotic Checkpoint and Chromosomal Polyploidy through the Rb Pathway

M. Lai, K. Machida, G. McNamara, 2009, Journal of Virology.

Polo-Like Kinase 1 Is Involved in Hepatitis C Virus Replication by Hyperphosphorylating NS5A

M. Lai, K. Machida, Wen-Chi Su, 2010, Journal of Virology.

Hepatitis C Virus Induces Toll-Like Receptor 4 Expression, Leading to Enhanced Production of Beta Interferon and Interleukin-6

M. Lai, K. Machida, S. Foung, 2006, Journal of Virology.

Lymphotropism of Hepatitis C Virus

M. Lai, K. Machida, 2012 .

Tumor-initiating stem-like cells and drug resistance: carcinogenesis through Toll-like receptors, environmental factors, and virus

K. Machida, 2012, Drug Delivery and Translational Research.

Cancer stem cells generated by alcohol, diabetes, and hepatitis C virus

K. Machida, H. Tsukamoto, S. French, 2012, Journal of gastroenterology and hepatology.

TLRs, Alcohol, HCV, and Tumorigenesis

K. Machida, 2011, Gastroenterology research and practice.

Molecular Mechanism of Hepatitis C Virus Carcinogenesis

M. Lai, K. Machida, J. Ou, 2010 .

Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog

R. Ray, M. Lai, R. Deshaies, 2009, Proceedings of the National Academy of Sciences.

Mitophagy Controls the Activities of Tumor Suppressor p53 to Regulate Hepatic Cancer Stem Cells.

K. Machida, J. Ou, Jiyoung Lee, 2017, Molecular cell.

Hepatitis C virus has a genetically determined lymphotropism through co-receptor B7.2

F. Cosset, M. Lai, Y. Kondo, 2017, Nature Communications.

Inhibition of RIG-I-Mediated Signaling by Kaposi's Sarcoma-Associated Herpesvirus-Encoded Deubiquitinase ORF64

K. Machida, Jae U. Jung, Kyung-Soo Inn, 2011, Journal of Virology.

Inhibition of RIGI-Mediated Signaling by Kaposi ’ s Sarcoma-Associated Herpesvirus-Encoded Deubiquitinase ORF 64

K. Machida, Jae U. Jung, Kyung-Soo Inn, 2011 .

Hepatitis C Virus (HCV)-Induced Immunoglobulin Hypermutation Reduces the Affinity and Neutralizing Activities of Antibodies against HCV Envelope Protein

J. Dubuisson, M. Lai, Y. Kondo, 2008, Journal of Virology.

Hepatitis C Virus E2-CD81 Interaction Induces Hypermutation of the Immunoglobulin Gene in B Cells

M. Lai, K. Machida, N. Pavio, 2005, Journal of Virology.

Hepatitis C virus induces a mutator phenotype: Enhanced mutations of immunoglobulin and protooncogenes

M. Lai, K. Machida, M. Lai, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Reciprocal regulation by TLR4 and TGF-β in tumor-initiating stem-like cells.

S. Dooley, K. Machida, L. Mishra, 2013, The Journal of clinical investigation.

Reciprocal regulation by TLR 4 and TGF-b in tumor-initiating stem-like cells

S. Dooley, K. Machida, L. Mishra, 2018 .

TLR4-dependent tumor-initiating stem cell-like cells (TICs) in alcohol-associated hepatocellular carcinogenesis.

K. Machida, H. Tsukamoto, D. Feldman, 2015, Advances in experimental medicine and biology.

Metabolically Reprograms Tumor-Initiating Stem-like Cells through Tumorigenic Changes in Oxidative Phosphorylation and Fatty Acid Metabolism

K. Machida, S. Hess, S. Tahara, 2015 .

Alcohol, TLR4-TGF-β antagonism, and liver cancer

K. Machida, L. Mishra, H. Tsukamoto, 2014, Hepatology International.

Cell fate, metabolic reprogramming and lncRNA of tumor-initiating stem-like cells induced by alcohol.

K. Machida, 2020, Chemico-biological interactions.

PPARs and Liver Disease

Y. Kondo, K. Machida, M. Terajima, 2013, PPAR research.

TGF-b/b2-spectrin/CTCF-regulated tumor suppression in human stem cell disorder Beckwith-Wiedemann syndrome

Nina M. Muñoz, Nipun A. Mistry, R. Weksberg, 2019 .

TGF-b / b 2-spectrin / CTCF-regulated tumor suppression in human stem cell disorder Beckwith-Wiedemann syndrome

Nina M. Muñoz, Nipun A. Mistry, R. Weksberg, 2019 .

TGF-β/β2-spectrin/CTCF-regulated tumor suppression in human stem cell disorder Beckwith-Wiedemann syndrome.

Nina M. Muñoz, Nipun A. Mistry, R. Weksberg, 2016, The Journal of clinical investigation.

Oncogenic signaling pathways and origins of tumor-initiating stem-like cells of hepatocellular carcinomas induced by hepatitis C virus, alcohol and/or obesity

K. Machida, H. Tsukamoto, Chia-Lin Chen, 2014, Hepatology International.

Tumor‐Initiating Stem‐Like Cells

K. Machida, 2014 .

A review of alcohol-pathogen interactions: New insights into combined disease pathomechanisms.

K. Machida, S. Weinman, K. Kharbanda, 2022, Alcoholism, clinical and experimental research.

Hepatitis C Virus Inhibits DNA Damage Repair through Reactive Oxygen and Nitrogen Species and by Interfering with the ATM-NBS1/Mre11/Rad50 DNA Repair Pathway in Monocytes and Hepatocytes

M. Lai, K. Machida, G. McNamara, 2010, The Journal of Immunology.

Pluripotency transcription factors and Metabolic reprogramming of mitochondria in tumor-initiating stem-like cells.

K. Machida, 2017, Antioxidants & redox signaling.

Pluripotency factor-mediated expression of the leptin receptor (OB-R) links obesity to oncogenesis through tumor-initiating stem cells

K. Machida, H. Tsukamoto, V. Punj, 2011, Proceedings of the National Academy of Sciences.

HCV Infection Enhances Th17 Commitment, Which Could Affect the Pathogenesis of Autoimmune Diseases

K. Nakayama, M. Lai, Y. Kondo, 2014, PloS one.

Lymphotropic HCV strain can infect human primary naïve CD4+ cells and affect their proliferation and IFN-γ secretion activity

Y. Kondo, K. Machida, M. Shiina, 2011, Journal of Gastroenterology.

Extrahepatic Replication of HCV

M. Lai, K. Machida, Wen-Chi Su, 2016 .

Transient Activation of the PI3K-AKT Pathway by Hepatitis C Virus to Enhance Viral Entry*

Keigo Machida, Yongjun Tian, M. Lai, 2012, The Journal of Biological Chemistry.

Morphogens and hepatic stellate cell fate regulation in chronic liver disease

K. Machida, H. Tsukamoto, Jiaohong Wang, 2012, Journal of gastroenterology and hepatology.

Hepatitis C Virus Infection Activates the Immunologic (Type II) Isoform of Nitric Oxide Synthase and Thereby Enhances DNA Damage and Mutations of Cellular Genes

M. Lai, K. Machida, A. Levine, 2004, Journal of Virology.

Loss of the TGF-β Effector β2SP Promotes Genomic Instability.

A. Rashid, L. Kwong, K. Machida, 2016, Hepatology.

Hepatitis C virus and disrupted interferon signaling promote lymphoproliferation via type II CD95 and interleukins.

H. Yonekawa, K. Machida, M. Kohara, 2009, Gastroenterology.

Hepatitis C Virus Egress and Release Depend on Endosomal Trafficking of Core Protein

M. Lai, K. Machida, K. Jeng, 2010, Journal of Virology.

Hepatitis C Virus Egress and Release Depend on Endosomal Trafﬁcking of Core Protein (cid:1)

K. Machida, K. Jeng, Chao-Kuen Lai, 2010 .

NANOG-Dependent Metabolic Reprogramming and Symmetric Division in Tumor-Initiating Stem-like Cells.

K. Machida, 2018, Advances in experimental medicine and biology.

Transcriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and chemoresistance

Qingsong Liu, K. Machida, Weiming Yuan, 2019, Nature Communications.

Inhibition of Cytochrome c Release in Fas-mediated Signaling Pathway in Transgenic Mice Induced to Express Hepatitis C Viral Proteins*

F. Shibasaki, H. Yonekawa, K. Machida, 2001, The Journal of Biological Chemistry.

p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs

R. Ray, K. Machida, H. Choi, 2020, Nature Communications.

c‐Jun mediates hepatitis C virus hepatocarcinogenesis through signal transducer and activator of transcription 3 and nitric oxide–dependent impairment of oxidative DNA repair

S. Akira, M. Lai, K. Machida, 2010, Hepatology.

Regulation of Hepatitis C Virus Infection by Cellular Retinoic Acid Binding Proteins through the Modulation of Lipid Droplet Abundance

K. Machida, Jae U. Jung, H. Aoyagi, 2019, Journal of Virology.

“Second Hit” Models of Alcoholic Liver Disease

K. Machida, H. Tsukamoto, H. Mkrtchyan, 2009, Seminars in liver disease.

Genes DNA Damage and Mutations of Cellular Oxide Synthase and Thereby Enhances Immunologic ( Type II ) Isoform of Nitric Hepatitis C Virus Infection Activates the

M. Lai, K. Machida, A. Levine, 2004 .

Profiling of Circulating Tumor Cells for Screening of Selective Inhibitors of Tumor‐Initiating Stem‐Like Cells

Ameya R. Kirtane, K. Machida, A. El-Khoueiry, 2023, Advanced science.

Transcriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and chemoresistance

Qingsong Liu, K. Machida, Weiming Yuan, 2019, Nature Communications.

LIN28 and histone H3K4 methylase induce TLR4 to generate tumor-initiating stem-like cells

K. Machida, Jae U. Jung, H. Tsukamoto, 2023, iScience.

GRP78 Inhibitor YUM70 Suppresses SARS-CoV-2 Viral Entry, Spike Protein Production and Ameliorates Lung Damage

N. Neamati, K. Machida, Amy S. Lee, 2023, Viruses.

Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers

Yong Zhang, Keigo Machida, Chengyu Liang, 2015, Nature Communications.

Hepatic stellate cell stearoyl co-A desaturase activates leukotriene B4 receptor 2 - β-catenin cascade to promote liver tumorigenesis

M. Karin, E. Guccione, K. Machida, 2023, Nature communications.

Tumor-initiating stem-like cells and drug resistance: carcinogenesis through Toll-like receptors, environmental factors, and virus

K. Machida, 2013, Drug Delivery and Translational Research.

Title Necrostatin-1 protects against reactive oxygen species (ROS)- induced hepatotoxicity in acetaminophen-induced acute liver failure

K. Iwaisako, K. Machida, E. Hatano, 2018 .

Loss of the transforming growth factor‐β effector β2‐Spectrin promotes genomic instability

A. Rashid, L. Kwong, K. Machida, 2017, Hepatology.

In vitro selection of RNA aptamers that can bind specifically to Tat protein of HIV-1.

K. Machida, K. Taira, S. Nishikawa, 1995, Nucleic Acids Symposium Series.

HCV core expression in hepatocytes protects against autoimmune liver injury and promotes liver regeneration in mice

M. Lai, K. Machida, S. Govindarajan, 2006, Hepatology.

Hepatitis C virus infection of T cells inhibits proliferation and enhances fas-mediated apoptosis by down-regulating the expression of CD44 splicing variant 6.

M. Lai, Y. Kondo, K. Machida, 2009, The Journal of infectious diseases.

Hepatitis C virus infects T cells and affects interferon-gamma signaling in T cell lines.

M. Lai, Y. Kondo, K. Machida, 2007, Virology.

Hepatitis C Virus Translation Preferentially Depends on Active RNA Replication

M. Lai, K. Machida, H. Aizaki, 2012, PloS one.

Therapeutic control of hepatitis C virus: the role of neutralizing monoclonal antibodies.

J. Ball, M. Lai, K. Machida, 2008, Current topics in microbiology and immunology.

Polycomb repressive complex 2 binds and stabilizes NANOG to suppress differentiation-related genes to promote self-renewal

K. Machida, H. Tsukamoto, S. Tahara, 2023, iScience.