Kevin Lee

发表

Epigenetic protein families: a new frontier for drug discovery

C. Bountra, C. Arrowsmith, P. Fish, 2012, Nature Reviews Drug Discovery.

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

Christopher J. Schofield, Cesar Ramirez-Molina, Udo Oppermann, 2012, Nature.

Suppression of inflammation by a synthetic histone mimic

C. Rice, A. Tarakhovsky, R. Prinjha, 2010, Nature.

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

S. Robson, G. Drewes, M. Bantscheff, 2011, Nature.

Identification of a novel series of BET family bromodomain inhibitors: binding mode and profile of I-BET151 (GSK1210151A).

David M. Wilson, P. Bamborough, R. Prinjha, 2012, Bioorganic & medicinal chemistry letters.

Discovery and characterization of small molecule inhibitors of the BET family bromodomains.

P. Bamborough, R. Prinjha, R. Grimley, 2011, Journal of medicinal chemistry.

Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling

Ruth I. Tennen, B. Garcia, C. Liu, 2011, Nature Immunology.

Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain Inhibitor Highlights Therapeutic Opportunities.

Kevin Lee, R. Denny, M. Pletcher, 2015, Chemistry & biology.

Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives.

David M. Wilson, Melanie V. Leveridge, G. Drewes, 2016, Journal of medicinal chemistry.

Histone H3 lysine 9 di-methylation as an epigenetic signature of the interferon response

Scott B. Dewell, C. Rice, A. Tarakhovsky, 2012, The Journal of experimental medicine.

Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and β cells

R. Weissleder, C. Benoist, R. Prinjha, 2014, eLife.

Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors

J. Greenbaum, Bjoern Peters, R. Prinjha, 2012, Proceedings of the National Academy of Sciences.

Suppression of the antiviral response by an influenza histone mimic

A. Tarakhovsky, R. Roeder, R. Prinjha, 2012, Nature.

Interrogating the Druggability of the 2-Oxoglutarate-Dependent Dioxygenase Target Class by Chemical Proteomics.

David M. Wilson, G. Drewes, Markus Boesche, 2016, ACS chemical biology.

Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy.

Andrew J. Bannister, S. Robson, S. Knapp, 2015, Cancer research.

Inhibition of Osteoclastogenesis and Inflammatory Bone Resorption by Targeting BET Proteins and Epigenetic Regulation

P. Tak, R. Prinjha, Kevin Lee, 2014, Nature Communications.

BET bromodomain inhibitors show anti‐papillomavirus activity in vitro and block CRPV wart growth in vivo

R. Prinjha, Kevin Lee, S. Brendle, 2018, Antiviral research.

SETD6 lysine methylation of RelA couples GLP activity at chromatin to tonic repression of NF-κB signaling

Ruth I. Tennen, B. Garcia, C. Liu, 2010, Nature Immunology.

Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 1. 3-Amino-4-pyridine Carboxylate Derivatives.

Douglas W. Thomson, David M. Wilson, Melanie V. Leveridge, 2016, Journal of medicinal chemistry.

SETD 6 lysine methylation of RelA couples GLP activity at chromatin to tonic repression of NF-κ B signaling

Ruth I. Tennen, C. Liu, A. Tarakhovsky, 2012 .

Recurrent mutations, including NPM1c, activate a BRD4-dependent core transcriptional program in acute myeloid leukemia

S. Robson, G. Drewes, L. Bullinger, 2013, Leukemia.