Sheng-Cai Lin

发表

The Ets transcription factor GABP is a component of the hippo pathway essential for growth and antioxidant defense.

F. Camargo, Xianming Deng, Hongtan Wu, 2013, Cell Reports.

Axin determines cell fate by controlling the p53 activation threshold after DNA damage

Jiahuai Han, Sheng-Cai Lin, Yanhai Wang, 2009, Nature Cell Biology.

Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation

Jiahuai Han, Sheng-Cai Lin, Qinxi Li, 2004, The EMBO journal.

Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK

Sheng-Cai Lin, D. Hardie, S. Hawley, 2017, Nature.

Axin: A Master Scaffold for Multiple Signaling Pathways

Sheng-Cai Lin, W. Luo, 2004, Neurosignals.

SUMO-1 Modification of the C-terminal KVEKVD of Axin Is Required for JNK Activation but Has No Effect on Wnt Signaling*

Sheng-Cai Lin, Zhen Xu, Hongliang Rui, 2002, The Journal of Biological Chemistry.

Axin Contains Three Separable Domains That Confer Intramolecular, Homodimeric, and Heterodimeric Interactions Involved in Distinct Functions*

Sheng-Cai Lin, Qinxi Li, Shuyong Lin, 2005, Journal of Biological Chemistry.

A CBP Integrator Complex Mediates Transcriptional Activation and AP-1 Inhibition by Nuclear Receptors

Thorsten Heinzel, C. Glass, M. Rosenfeld, 1996, Cell.

Involvement of MicroRNA in AU-Rich Element-Mediated mRNA Instability

Shuang Huang, Qing Jing, Jiahuai Han, 2005, Cell.

Determinants That Control the Distinct Subcellular Localization of p38α-PRAK and p38β-PRAK Complexes*

Jiahuai Han, Sheng-Cai Lin, Yanhai Wang, 2008, Journal of Biological Chemistry.

Rock2 controls TGFβ signaling and inhibits mesoderm induction in zebrafish embryos

Sheng-Cai Lin, A. Meng, Haiwen Zhang, 2009, Journal of Cell Science.

Aldolase is a sensor for both low and high glucose, linking to AMPK and mTORC1

Sheng-Cai Lin, D. Hardie, S. Hawley, 2020, Cell Research.

Identification of novel SNPs by next-generation sequencing of the genomic region containing the APC gene in colorectal cancer patients in China.

Fan Mo, B. Lin, Sheng-Cai Lin, 2010, Omics : a journal of integrative biology.

Identification of Drosophila miRNA that Is Involved in the Regulation of ARE mRNA Stability in S 2 Cells

Jiahuai Han, Shuang Huang, Sheng-Cai Lin, 2005 .

A Suppressive Role of the Prolyl Isomerase Pin1 in Cellular Apoptosis Mediated by the Death-associated Protein Daxx*

Sam W. Lee, A. Ryo, Sheng-Cai Lin, 2007, Journal of Biological Chemistry.

PLK1 Interacts and Phosphorylates Axin That Is Essential for Proper Centrosome Formation

Sheng-Cai Lin, Y. Liou, Ka Ruan, 2012, PloS one.

Structure and mechanism of the unique C2 domain of Aida

Zhi-Xin Wang, Sheng-Cai Lin, Ying Wang, 2014, The FEBS journal.

The Axin/TNKS complex interacts with KIF3A and is required for insulin-stimulated GLUT4 translocation

Sheng-Cai Lin, Qinxi Li, G. Lian, 2012, Cell Research.

Proto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy

E. Song, Zhihua Liu, Sheng-Cai Lin, 2020, Nature Communications.

Cdk5-Mediated Phosphorylation of Axin Directs Axon Formation during Cerebral Cortex Development

Rui Li, Sheng-Cai Lin, J. P. Ip, 2011, The Journal of Neuroscience.

AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity.

W. Jia, Peng Li, Sheng-Cai Lin, 2018, Cell metabolism.

AIDA directly connects sympathetic innervation to adaptive thermogenesis by UCP1

Sheng-Cai Lin, Tong-Jin Zhao, Guang Li, 2021, Nature Cell Biology.

AMP-activated protein kinase – not just an energy sensor

Sheng-Cai Lin, D. Hardie, 2017, F1000Research.

AMP-activated protein kinase – not just an energy sensor

Sheng-Cai Lin, D. Hardie, 2017, F1000Research.

Glucose Starvation Blocks Translation at Multiple Levels.

Sheng-Cai Lin, D. Hardie, Chen-Song Zhang, 2020, Cell metabolism.

Metaxin is required for tumor necrosis factor‐induced cell death

Jiahuai Han, Sheng-Cai Lin, V. Kravchenko, 2001, EMBO reports.

Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate

Sheng-Cai Lin, G. Shui, K. Reue, 2018, Nature Communications.

CIDE-A, a novel link between brown adipose tissue and obesity.

Peng Li, Sheng-Cai Lin, Peng Li, 2004, Trends in molecular medicine.

Pit-1-dependent expression of the receptor for growth hormone releasing factor mediates pituitary cell growth

M. Rosenfeld, Sheng-Cai Lin, Chijen R. Lin, 1992, Nature.

Tob1 controls dorsal development of zebrafish embryos by antagonizing maternal beta-catenin transcriptional activity.

Sheng-Cai Lin, Shuyong Lin, Ye Guang Chen, 2006, Developmental cell.

Identification of serum metabolites enhancing inflammatory responses in COVID-19

Xiufeng Sun, Sheng-Cai Lin, Dawang Zhou, 2022, Science China Life Sciences.

Differential requirement of MKK4 and MKK7 in JNK activation by distinct scaffold proteins

Jiahuai Han, Sheng-Cai Lin, Qinxi Li, 2007, FEBS letters.

The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK

Xianming Deng, Xiufeng Sun, Sheng-Cai Lin, 2022, Nature Metabolism.

Regulation of Cidea protein stability by the ubiquitin-mediated proteasomal degradation pathway.

Peng Li, Sheng-Cai Lin, S. Chan, 2007, The Biochemical journal.

Carbohydrates: Not All that Bad?

Sheng-Cai Lin, Chen-Song Zhang, Shu-Yong Lin, 2018, Cell metabolism.

A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida.

Jiahuai Han, Min Zhang, Sheng-Cai Lin, 2007, Developmental cell.

SRC promotes lipogenesis: implications for obesity and breast cancer

Sheng-Cai Lin, Shu-Yong Lin, 2021, Molecular & cellular oncology.

AMPK: Sensing Glucose as well as Cellular Energy Status.

Sheng-Cai Lin, D. Hardie, D. Hardie, 2017, Cell metabolism.

AMPK directly phosphorylates TBK1 to integrate glucose sensing into innate immunity.

T. Liang, Sheng-Cai Lin, Xin-Hua Feng, 2022, Molecular cell.

β-actin is required for mitochondria clustering and ROS generation in TNF-induced, caspase-independent cell death

Jiahuai Han, Sheng-Cai Lin, Qinxi Li, 2004, Journal of Cell Science.

Cidea-deficient mice have lean phenotype and are resistant to obesity

Sheng-Cai Lin, W. Hong, P. Li, 2003, Nature Genetics.

The kinases Mst 1 and Mst 2 positively regulate phagocyte ROS induction and bactericidal activity

Jiahuai Han, Hongtan Wu, Shihao Zhang, 2016 .

The BNIP-2 and Cdc42GAP Homology (BCH) Domain of p50RhoGAP/Cdc42GAP Sequesters RhoA from Inactivation by the Adjacent GTPase-activating Protein Domain

Sheng-Cai Lin, B. C. Low, Yi Ting Zhou, 2010, Molecular biology of the cell.

Molecular basis of the little mouse phenotype and Implications for cell type-specific growth

Aldons J. Lusis, Paul E. Sawchenko, Michael G. Rosenfeld, 1993, Nature.

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

Na Zhang, Meng-Qiu Dong, Jiahuai Han, 2009, Science.

Axin determines cell fate by controlling the p53 activation threshold after DNA damage

Qinxi Li, Yanhai Wang, Jiahuai Han, 2009, Nature Cell Biology.

ChIP-seq and functional analysis of the SOX2 gene in colorectal cancers.

Sheng-Cai Lin, X. Fang, Z. Ye, 2010, Omics : a journal of integrative biology.

A conserved motif in JNK/p38-specific MAPK phosphatases as a determinant for JNK1 recognition and inactivation

Zhi-Xin Wang, Sheng-Cai Lin, Chang Lu, 2016, Nature Communications.

Axin negatively affects tau phosphorylation by glycogen synthase kinase 3β

Sheng-Cai Lin, G. Johnson, W. Stoothoff, 2002, Journal of neurochemistry.

Differential Molecular Assemblies Underlie the Dual Function of Axin in Modulating the Wnt and JNK Pathways*

Sheng-Cai Lin, S. Neo, S. C. Lin, 2001, The Journal of Biological Chemistry.

AMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control.

Sheng-Cai Lin, D. Hardie, D. Hardie, 2020, Cell metabolism.

Axin Utilizes Distinct Regions for Competitive MEKK1 and MEKK4 Binding and JNK Activation*

Jiahuai Han, Sheng-Cai Lin, Z. Ye, 2003, Journal of Biological Chemistry.

Molecular Basis of Wnt Activation via the DIX Domain Protein Ccd1*

Zhi-Xin Wang, Sheng-Cai Lin, Qinxi Li, 2010, The Journal of Biological Chemistry.

Detection of point mutations of the Axin1 gene in colorectal cancers

Sheng-Cai Lin, W. Luo, Lihua Jin, 2003, International journal of cancer.

1 1 2 3 4 AMPK and TOR : the Yin and Yang of cellular nutrient sensing and growth control 5 6

Sheng-Cai Lin, D. Hardie, A. González, 2020 .

Axin is a scaffold protein in TGF‐β signaling that promotes degradation of Smad7 by Arkadia

Jiahuai Han, Mingliang Chen, Sheng-Cai Lin, 2006, The EMBO journal.

The kinases Mst1 and Mst2 positively regulate phagocyte ROS induction and bactericidal activity

Jiahuai Han, Hongtan Wu, Shihao Zhang, 2015, Nature Immunology.

Protein Encoded by the AxinFu Allele Effectively Down-regulates Wnt Signaling but Exerts a Dominant Negative Effect on c-Jun N-terminal Kinase Signaling*

Sheng-Cai Lin, Yanhai Wang, Qinxi Li, 2008, Journal of Biological Chemistry.

Nuclear UHRF1 is a gate-keeper of cellular AMPK activity and function

Xiang Xu, Sheng-Cai Lin, J. Wong, 2021, Cell research.

Characterization of a Novel Mammalian RGS Protein That Binds to Gα Proteins and Inhibits Pheromone Signaling in Yeast*

Jiahuai Han, Sheng-Cai Lin, Canhe Chen, 1997, The Journal of Biological Chemistry.

POU Domain Transcription Factors in the Neuroendocrine System

E. Turner, M. Rosenfeld, Sheng-Cai Lin, 1995 .

Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK

Sheng-Cai Lin, D. Hardie, Z. Ye, 2019, Cell metabolism.

AMP as a low-energy charge signal autonomously initiates assembly of AXIN-AMPK-LKB1 complex for AMPK activation.

Jiahuai Han, Sheng-Cai Lin, Huiling Guo, 2013, Cell metabolism.

Daxx cooperates with the Axin/HIPK2/p53 complex to induce cell death.

Sheng-Cai Lin, Y. Liou, Qinxi Li, 2007, Cancer research.

Cytosporone B is an agonist for nuclear orphan receptor Nur77.

B. Weimer, Si-Yang Song, Sheng-Cai Lin, 2008, Nature chemical biology.

Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy depletion-induced suppression of mTORC1

Jiahuai Han, M. Dong, Sheng-Cai Lin, 2010, Nature Cell Biology.

The DIX Domain Protein Coiled-coil-DIX1 Inhibits c-Jun N-terminal Kinase Activation by Axin and Dishevelled through Distinct Mechanisms*

Sheng-Cai Lin, Z. Ye, W. Luo, 2004, Journal of Biological Chemistry.

The Membrane Association Domain of RGS16 Contains Unique Amphipathic Features That Are Conserved in RGS4 and RGS5*

Sheng-Cai Lin, L. Yaw, Canhe Chen, 1999, The Journal of Biological Chemistry.

The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK.

Qiao Wu, Tianwei Lin, Yuan Wang, 2012, Nature chemical biology.

Axin Forms a Complex with MEKK1 and Activates c-Jun NH2-terminal Kinase/Stress-activated Protein Kinase through Domains Distinct from Wnt Signaling*

Jiahuai Han, Sheng-Cai Lin, S. Neo, 1999, The Journal of Biological Chemistry.

RGS16 Attenuates Gαq-dependent p38 Mitogen-activated Protein Kinase Activation by Platelet-activating Factor*

Jiahuai Han, Sheng-Cai Lin, S. Neo, 1999, The Journal of Biological Chemistry.

AMPK Promotes Autophagy by Facilitating Mitochondrial Fission.

Sheng-Cai Lin, Chen-Song Zhang, 2016, Cell metabolism.

Glutaminase GLS1 senses glutamine availability in a non-enzymatic manner triggering mitochondrial fusion

Sheng-Cai Lin, Z. Ye, Chen-Song Zhang, 2018, Cell Research.

β-Catenin 1 and β-catenin 2 play similar and distinct roles in left-right asymmetric development of zebrafish embryos

M. Zhang, Sheng-Cai Lin, A. Meng, 2012, Development.

Ephrin-B1 Reverse Signaling Activates JNK through a Novel Mechanism That Is Independent of Tyrosine Phosphorylation*

Sheng-Cai Lin, Zhen Xu, Hai-Meng Zhou, 2003, Journal of Biological Chemistry.

ChIP-seq and functional analysis of the SOX2 gene in colorectal cancers.

Sheng-Cai Lin, X. Fang, Z. Ye, 2010, Omics : a journal of integrative biology.

Aldolase deployed for surveilling glucose

Sheng-Cai Lin, 2020, Nature Reviews Molecular Cell Biology.

The core protein of glypican Dally-like determines its biphasic activity in wingless morphogen signaling.

Sheng-Cai Lin, D. Yan, Xinhua Lin, 2009, Developmental cell.

Determining AMPK Activation via the Lysosomal v-ATPase-Ragulator-AXIN/LKB1 Axis.

Sheng-Cai Lin, Chen-Song Zhang, Yue Zong, 2018, Methods in molecular biology.

Distinct Roles of Basal Steady-State and Induced H-Ferritin in Tumor Necrosis Factor-Induced Death in L929 Cells

Jiahuai Han, Sheng-Cai Lin, Qinxi Li, 2005, Molecular and Cellular Biology.

Pharmacological Targeting of Vacuolar H+-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer.

A. Dastur, Patricia Greninger, Xianming Deng, 2020, Cell chemical biology.

Casein Kinase I and Casein Kinase II Differentially Regulate Axin Function in Wnt and JNK Pathways*

Jiahuai Han, Sheng-Cai Lin, Yi Zhang, 2002, The Journal of Biological Chemistry.

Protein phosphorylation-acetylation cascade connects growth factor deprivation to autophagy

Jiahuai Han, Jiawei Wu, Sheng-Cai Lin, 2012, Autophagy.

Apoptosis signaling pathway in T cells is composed of ICE/Ced-3 family proteases and MAP kinase kinase 6b.

G. Nemerow, Jiahuai Han, E. Nishida, 1997, Immunity.

Dimerization Choices Control the Ability of Axin and Dishevelled to Activate c-Jun N-terminal Kinase/Stress-activated Protein Kinase*

Jiahuai Han, Sheng-Cai Lin, S. Neo, 2000, The Journal of Biological Chemistry.

Ephrin-B1 Reverse Signaling Activates JNK through a Novel Mechanism That Is Independent of Tyrosine Phosphorylation*

Sheng-Cai Lin, Zhen Xu, Hai-Meng Zhou, 2003, Journal of Biological Chemistry.

AMPK Promotes Autophagy by Facilitating Mitochondrial Fission.

Sheng-Cai Lin, Chen-Song Zhang, 2016, Cell metabolism.

Glutaminase GLS1 senses glutamine availability in a non-enzymatic manner triggering mitochondrial fusion

Sheng-Cai Lin, Chen-Song Zhang, Cixiong Zhang, 2018, Cell Research.