J. Hayashi

发表

Introduction of disease-related mitochondrial DNA deletions into HeLa cells lacking mitochondrial DNA results in mitochondrial dysfunction.

J. Hayashi, S. Ohta, A. Kikuchi, 1991, Proceedings of the National Academy of Sciences of the United States of America.

ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis

J. Hayashi, Y. Honma, Kaori Ishikawa, 2008, Science.

Simple Method of Zygosity Identification in Transgenic Mice by Real-time Quantitative PCR

H. Yonekawa, J. Hayashi, H. Shitara, 2004, Transgenic Research.

Strictly maternal inheritance of rat mitochondrial DNA.

O. Gotoh, H. Yonekawa, J. Hayashi, 1978, Biochemical and biophysical research communications.

Hypoxic induction of hypoxia-inducible factor-1alpha and oxygen-regulated gene expression in mitochondrial DNA-depleted HeLa cells.

M. Gassmann, J. Hayashi, K. Takenaga, 2002, Biochemical and biophysical research communications.

Reactive Oxygen Species-generating Mitochondrial DNA Mutation Up-regulates Hypoxia-inducible Factor-1α Gene Transcription via Phosphatidylinositol 3-Kinase-Akt/Protein Kinase C/Histone Deacetylase Pathway*

J. Hayashi, A. Nakagawara, K. Takenaga, 2009, The Journal of Biological Chemistry.

Polymorphic mutations in mouse mitochondrial DNA regulate a tumor phenotype.

Y. Kikkawa, J. Hayashi, Kaori Ishikawa, 2013, Mitochondrion.

Gene therapy of mitochondrial diseases using human cytoplasts

Y. Kagawa, J. Hayashi, 1997, Gene Therapy.

The Influence of ATP Synthase 8, 6 Gene Polymorphisms on the Individual Difference of Endurance Capacity or its Trainability

S. Kuno, J. Hayashi, R. Ajisaka, 2006 .

Long-term postmortem survival of mitochondrial genomes in mouse synaptosomes and their rescue in a mitochondrial DNA-less mouse cell line.

J. Hayashi, M. Kaneko, S. Ito, 1998, Biochemical and biophysical research communications.

Acute exercise causes mitochondrial DNA deletion in rat skeletal muscle

J. Hayashi, H. Nagata, N. Ohkoshi, 1999, Muscle & nerve.

Mammalian Copper Chaperone Cox17p Has an Essential Role in Activation of Cytochrome c Oxidase and Embryonic Development

J. Hayashi, H. Kodama, T. Baba, 2002, Molecular and Cellular Biology.

Development Oxidase and Embryonic c Cytochrome an Essential Role in Activation of Mammalian Copper Chaperone Cox 17 p Has

J. Hayashi, H. Kodama, T. Baba, 2002 .

Age-associated changes of mitochondrial translation and respiratory function in mouse brain.

Y. Kagawa, J. Hayashi, D. Takai, 1995, Biochemical and biophysical research communications.

Nuclear but not mitochondrial genome involvement in human age-related mitochondrial dysfunction. Functional integrity of mitochondrial DNA from aged subjects.

Y. Kagawa, H. Yonekawa, J. Hayashi, 1994, The Journal of biological chemistry.

Evolutionary relationships among five subspecies of Mus musculus based on restriction enzyme cleavage patterns of mitochondrial DNA.

O. Gotoh, H. Yonekawa, J. Hayashi, 1981, Genetics.

Positioning of the A . T-rich regions in rat mitochondrial DNA by electron microscopy and analysis of the hysteresis of denaturation.

O. Gotoh, H. Yonekawa, J. Hayashi, 1978, Biochimica et biophysica acta.

Absence of extensive recombination between inter- and intraspecies mitochondrial DNA in mammalian cells.

J. Hayashi, M. Yoshida, Y. Tagashira, 1985, Experimental cell research.

Non‐invasive visualization of sperm mitochondria behavior in transgenic mice with introduced green fluorescent protein (GFP)

H. Yonekawa, J. Hayashi, H. Shitara, 2001, FEBS letters.

Ditercalinium chloride, a pro-anticancer drug, intimately associates with mammalian mitochondrial DNA and inhibits its replication

J. Hayashi, N. Hamasaki, D. Kang, 2003, Current Genetics.

A general characteristic of tumor mitochondria: leakage of endogenous Mg2+ on incubation with uncoupler and resultant reduction of uncoupler-stimulated ATPase activity.

O. Gotoh, J. Hayashi, Y. Tagashira, 1980, Archives of biochemistry and biophysics.

Effects of ethidium bromide treatment of mouse cells on expression and assembly of nuclear-coded subunits of complexes involved in the oxidative phosphorylation.

Y. Kagawa, H. Yonekawa, J. Hayashi, 1990, Biochemical and biophysical research communications.

Two distinct types of mitochondrial DNA segregation in mouse-rat hybrid cells. Stochastic segregation and chromosome-dependent segregation.

J. Hayashi, M. Yoshida, T. Sekiguchi, 1983, Experimental cell research.

Isolation and characterization of mitochondrial DNA-less lines from various mammalian cell lines by application of an anticancer drug, ditercalinium.

J. Hayashi, E. Ségal-Bendirdjian, J. Lepecq, 1997, Biochemical and biophysical research communications.

Elimination of paternal mitochondrial DNA in intraspecific crosses during early mouse embryogenesis.

H. Yonekawa, J. Hayashi, C. Taya, 1995, Proceedings of the National Academy of Sciences of the United States of America.

In Vivo Interaction Between Mitochondria Carrying mtDNAs From Different Mouse Species

H. Yonekawa, J. Hayashi, H. Shitara, 2004, Genetics.

Recovery of the missing tumorigenicity in mitochondrial DNA-less HeLa cells by introduction of mitochondrial DNA from normal human cells

J. Hayashi, M. Takemitsu, I. Nonaka, 1992, Somatic cell and molecular genetics.

Smaller isoform of human mitochondrial transcription factor 1: its wide distribution and production by alternative splicing.

Y. Kagawa, J. Hayashi, S. Ohta, 1993, Biochemical and biophysical research communications.

The mitochondrial bottleneck occurs without reduction of mtDNA content in female mouse germ cells

Takahiko Hara, Kuniya Abe, Hiroshi Imai, 2007, Nature Genetics.

Reverse genetic studies of mitochondrial DNA-based diseases using a mouse model

J. Hayashi, K. Nakada, A. Sato, 2008, Proceedings of the Japan Academy. Series B, Physical and biological sciences.

Gene therapy for progeny of mito-mice carrying pathogenic mtDNA by nuclear transplantation.

H. Yonekawa, J. Hayashi, T. Kono, 2005, Proceedings of the National Academy of Sciences of the United States of America.

RELATIONSHIP BETWEEN LABORATORY MICE AND THE SUBSPECIES MUS MUSCULUS DOMESTICUS BASED ON RESTRICTION ENDONUCLEASE CLEAVAGE PATTERNS OF MITOCHONDRIAL DNA

O. Gotoh, H. Yonekawa, J. Hayashi, 1980 .

Evolutionary aspects of variant types of rat mitochondrial DNA'S.

O. Gotoh, H. Yonekawa, J. Hayashi, 1979, Biochimica et biophysica acta.

Nuclear but not mitochondrial DNA involvement in respiratory complex I defects found in senescence-accelerated mouse strain, SAMP8.

J. Hayashi, Hirotake Imanishi, K. Nakada, 2011, Experimental animals.

Nuclear but not mitochondrial genome involvement in 3-methylcholanthrene-induced expression of tumorigenicity in mouse somatic cells.

H. Yonekawa, J. Hayashi, Y. Tagashira, 1989, Cancer research.

Isolation and characterization of intraspecific cybrids. Effect of mitochondrial DNA on their cellular properties.

J. Hayashi, M. Yoshida, H. Higashida, 1984, Experimental cell research.

Effect of mitochondrial DNA transmitted cytoplasmically from nontumorigenic to tumorigenic rat cells on the phenotypic expression of tumorigenicity.

J. Hayashi, M. Yoshida, T. Watanabe, 1984, Cancer research.

Effect of mitochondrial DNA composition on the cellular properties of interspecific hybrid cells.

J. Hayashi, T. Watanabe, T. Sekiguchi, 1983, Experimental cell research.

Identification of Inheritance Modes of Mitochondrial Diseases by Introduction of Pure Nuclei from mtDNA-less HeLa Cells to Patient-derived Fibroblasts*

J. Hayashi, Kimiko Inoue, S. Miyabayashi, 1997, The Journal of Biological Chemistry.

The Interorganellar Interaction between Distinct Human Mitochondria with Deletion Mutant mtDNA from a Patient with Mitochondrial Disease and with HeLa mtDNA*

J. Hayashi, I. Nonaka, D. Takai, 1997, The Journal of Biological Chemistry.

Mitochondrial DNA Is Required for Regulation of Glucose-stimulated Insulin Secretion in a Mouse Pancreatic Beta Cell Line, MIN6*

J. Hayashi, H. Ishihara, D. Takai, 1996, The Journal of Biological Chemistry.

Mitochondrial genomes in intraspecies mammalian cell hybrids display codominant or dominant/recessive behavior.

J. Shay, H. Yonekawa, J. Hayashi, 1987, Experimental cell research.

Effects of normal human fibroblast mitochondrial DNA on segregation of HeLaTG Mitochondrial DNA and on tumorigenicity of HeLaTG cells.

J. Shay, J. Hayashi, H. Werbin, 1986, Cancer research.

Stability of parental mitochondrial DNA species and expression of nuclear ribosomal RNA genes in mouse-rat hybrid cells.

J. Hayashi, M. Yoshida, M. Tosu, 1982, Experimental cell research.

Mitochondrial DNA analysis of mouse-rat hybrid cells: Effect of chloramphenicol selection on the relative amounts of parental mitochondrial DNAs

O. Gotoh, J. Hayashi, M. Yoshida, 1982, Somatic cell genetics.

Identification of mitochondrial DNA species in interspecific cybrids and reconstituted cells using restriction endonuclease

J. Hayashi, M. Tosu, T. Sekiguchi, 1980, FEBS letters.

Identification of cytoplasmically transferred mitochondrial DNA in female germlines of Drosophila and its propagation in the progeny

J. Hayashi, J. Murakami, 1988, Molecular and General Genetics MGG.

Analysis of mitochondrial DNA species in interspecific hybrid somatic cells using restriction endonucleases. Identification of recombinant mtDNA molecules.

O. Gotoh, J. Hayashi, M. Tosu, 1981, Experimental cell research.

Isolation of Mitochondrial DNA-less Mouse Cell Lines and Their Application for Trapping Mouse Synaptosomal Mitochondrial DNA with Deletion Mutations*

Y. Kagawa, J. Hayashi, E. Ségal-Bendirdjian, 1997, The Journal of Biological Chemistry.

Mitochondrial respiration defects modulate differentiation but not proliferation of hematopoietic stem and progenitor cells

Hiroyuki Miyoshi, Kazuto Nakada, J. Hayashi, 2010, FEBS letters.

The differences between the primary structures of mitochondrial DNAs from rat liver and ascites hepatoma (AH-130).

O. Gotoh, H. Yonekawa, J. Hayashi, 1978, Cancer letters.

Correlation of functional and ultrastructural abnormalities of mitochondria in mouse heart carrying a pathogenic mutant mtDNA with a 4696-bp deletion.

J. Hayashi, Y. Goto, I. Nonaka, 2001, Biochemical and biophysical research communications.

Propofol induces a metabolic switch to glycolysis and cell death in a mitochondrial electron transport chain-dependent manner

J. Hayashi, K. Nishi, T. Adachi, 2017, bioRxiv.

Epigenetic regulation of the nuclear-coded GCAT and SHMT2 genes confers human age-associated mitochondrial respiration defects

Hiroyuki Miyoshi, Hiroyuki Mano, Kazuto Nakada, 2015, Scientific Reports.

Direct cloning of full-length mouse mitochondrial DNA using a Bacillus subtilis genome vector.

Shinya Kaneko, Mitsuhiro Itaya, Kazuto Nakada, 2007, Gene.

An improved method for estimating sequence divergence between related DNAs from changes in restriction endonuclease cleavage sites

O. Gotoh, H. Yonekawa, J. Hayashi, 1979, Journal of Molecular Evolution.

Specific mtDNA Mutations in Mouse Carcinoma Cells Suppress Their Tumor Formation via Activation of the Host Innate Immune System

Y. Kikkawa, J. Hayashi, Kaori Ishikawa, 2013, PloS one.

The innate immune system in host mice targets cells with allogenic mitochondrial DNA

H. Yonekawa, J. Hayashi, Kaori Ishikawa, 2010, The Journal of experimental medicine.

Characterization of the mitochondrial protein LETM1, which maintains the mitochondrial tubular shapes and interacts with the AAA-ATPase BCS1L

Toshihiko Oka, J. Hayashi, K. Mihara, 2008, Journal of Cell Science.

Rare creation of recombinant mtDNA haplotypes in mammalian tissues

H. Yonekawa, J. Hayashi, H. Shitara, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Ethidium Bromide-induced Inhibition of Mitochondrial Gene Transcription Suppresses Glucose-stimulated Insulin Release in the Mouse Pancreatic β-Cell Line βHC9*

Y. Yazaki, J. Hayashi, Y. Terauchi, 1998, The Journal of Biological Chemistry.

Complete repopulation of mouse mitochondrial DNA-less cells with rat mitochondrial DNA restores mitochondrial translation but not mitochondrial respiratory function.

H. Yonekawa, J. Hayashi, H. Shitara, 2000, Genetics.

Mice with only rat mtDNA are required as models of mitochondrial diseases.

J. Hayashi, T. Ono, K. Nakada, 2001, Biochemical and biophysical research communications.

Selective and continuous elimination of mitochondria microinjected into mouse eggs from spermatids, but not from liver cells, occurs throughout embryogenesis.

H. Yonekawa, J. Hayashi, H. Shitara, 2000, Genetics.

Maternal inheritance of mouse mtDNA in interspecific hybrids: segregation of the leaked paternal mtDNA followed by the prevention of subsequent paternal leakage.

H. Yonekawa, J. Hayashi, H. Shitara, 1998, Genetics.

Suppression of disease phenotypes of adult mito-mice carrying pathogenic mtDNA by bone marrow transplantation.

J. Hayashi, H. Miyoshi, Kaori Ishikawa, 2006, Human molecular genetics.

Disruption of the mouse Shmt2 gene confers embryonic anaemia via foetal liver-specific metabolomic disorders

J. Hayashi, V. Velagapudi, A. Suomalainen, 2019, Scientific Reports.

Mito-mice∆ and mitochondrial DNA mutator mice as models of human osteoporosis caused not by aging but by hyperparathyroidism

J. Hayashi, Michiko Suzuki, Kaori Ishikawa, 2018, Experimental animals.

Mice deficient in the Shmt2 gene have mitochondrial respiration defects and are embryonic lethal

H. Yonekawa, J. Hayashi, H. Shitara, 2018, Scientific Reports.

Cytoplasmic transfer of heritable elements other than mtDNA from SAMP1 mice into mouse tumor cells suppresses their ability to form tumors in C57BL6 mice.

J. Hayashi, T. Hashimoto, Kaori Ishikawa, 2017, Biochemical and biophysical research communications.

Mutations in mitochondrial DNA regulate mitochondrial diseases and metastasis but do not regulate aging.

J. Hayashi, Kaori Ishikawa, O. Hashizume, 2016, Current opinion in genetics & development.

A somatic T15091C mutation in the Cytb gene of mouse mitochondrial DNA dominantly induces respiration defects.

J. Hayashi, Kaori Ishikawa, K. Nakada, 2015, Biochemical and biophysical research communications.

Inter-mitochondrial complementation: Mitochondria-specific system preventing mice from expression of disease phenotypes by mutant mtDNA

J. Hayashi, I. Nonaka, A. Ogura, 2001, Nature Medicine.

Human cells are protected from mitochondrial dysfunction by complementation of DNA products in fused mitochondria

J. Hayashi, T. Ono, K. Nakada, 2001, Nature Genetics.

Functional integrity of mitochondrial genomes in human platelets and autopsied brain tissues from elderly patients with Alzheimer's disease.

Y. Kagawa, S. Kuno, J. Hayashi, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Nuclear-recessive Mutations of Factors Involved in Mitochondrial Translation Are Responsible for Age-related Respiration Deficiency of Human Skin Fibroblasts*

Y. Kagawa, J. Hayashi, H. Kondo, 1998, The Journal of Biological Chemistry.

Human mitochondria and mitochondrial genome function as a single dynamic cellular unit

J. Hayashi, M. Takemitsu, Y. Goto, 1994, The Journal of cell biology.

Specific mitochondrial DNA mutation in mice regulates diabetes and lymphoma development

J. Hayashi, M. Ohira, H. Nagase, 2012, Proceedings of the National Academy of Sciences.

Generation of mtDNA-exchanged cybrids for determination of the effects of mtDNA mutations on tumor phenotypes.

J. Hayashi, Kaori Ishikawa, 2009, Methods in enzymology.

Pathogenic mitochondrial DNA‐induced respiration defects in hematopoietic cells result in anemia by suppressing erythroid differentiation

J. Hayashi, H. Miyoshi, K. Nakada, 2007, FEBS letters.

Influence of ageing on onset of mitochondrial disease

J. Hayashi, S. Miyabayashi, K. Tada, 1994, Journal of Inherited Metabolic Disease.

A 5-bp Insertion in Mip Causes Recessive Congenital Cataract in KFRS4/Kyo Rats

T. Serikawa, Y. Kikkawa, J. Hayashi, 2012, PloS one.

[Generation of mice with mitochondrial dysfunction by introducing mouse mtDNA carrying a deletion into zygotes].

J. Hayashi, K. Nakada, K. Inoue, 2001, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme.

Transcomplementation between Different Types of Respiration-deficient Mitochondria with Different Pathogenic Mutant Mitochondrial DNAs*

J. Hayashi, D. Takai, K. Isobe, 1999, The Journal of Biological Chemistry.

Regulation of metastasis; mitochondrial DNA mutations have appeared on stage

J. Hayashi, Kaori Ishikawa, K. Takenaga, 2012, Journal of Bioenergetics and Biomembranes.

Mitochondrial DNA Mutations Regulate Metastasis of Human Breast Cancer Cells

J. Hayashi, Kaori Ishikawa, K. Takenaga, 2011, PloS one.

A novel function of mtDNA: its involvement in metastasis

J. Hayashi, Kaori Ishikawa, 2010, Annals of the New York Academy of Sciences.

Trading mtDNA uncovers its role in metastasis

J. Hayashi, Kaori Ishikawa, 2009, Cell adhesion & migration.

Enhanced glycolysis induced by mtDNA mutations does not regulate metastasis

J. Hayashi, Kaori Ishikawa, K. Takenaga, 2008, FEBS letters.

Reversible regulation of metastasis by ROS-generating mtDNA mutations.

J. Hayashi, Kaori Ishikawa, K. Takenaga, 2008, Mitochondrion.

Effects of enhanced glycolysis by a mitochondrial DNA deletion mutation on expression of metastasis

J. Hayashi, Kaori Ishikawa, K. Takenaga, 2008 .

Nuclear DNA but not mtDNA controls tumor phenotypes in mouse cells.

H. Yonekawa, J. Hayashi, Y. Honma, 2005, Biochemical and biophysical research communications.

Effects of H2O2 Treatment of Mouse B82 Cells on mtDNA Amounts and Respiratory Function

Masahiro Tanaka, J. Hayashi, Chie Itoi, 2006 .

Deletion-Mutant mtDNA Increases in Somatic Tissues but Decreases in Female Germ Cells With Age

H. Yonekawa, J. Hayashi, H. Shitara, 2007, Genetics.

Mitochondrial dynamics and aging: Mitochondrial interaction preventing individuals from expression of respiratory deficiency caused by mutant mtDNA.

J. Hayashi, K. Nakada, A. Sato, 2006, Biochimica et biophysica acta.

Mitochondrial complementation preventing respiratory dysfunction caused by mutant mtDNA

J. Hayashi, K. Nakada, A. Sato, 2009, BioFactors.

Induction of a particular deletion in mitochondrial DNA by X rays depends on the inherent radiosensitivity of the cells.

T Inada, J. Hayashi, N. Kubota, 1997, Radiation research.

Lactic acidemia in the pathogenesis of mice carrying mitochondrial DNA with a deletion.

J. Hayashi, K. Nakada, E. Ogasawara, 2010, Human molecular genetics.

Accumulation of mtDNA with a mutation at position 3271 in tRNA(Leu)(UUR) gene introduced from a MELAS patient to HeLa cells lacking mtDNA results in progressive inhibition of mitochondrial respiratory function.

R. Sakuta, J. Hayashi, S. Ohta, 1993, Biochemical and biophysical research communications.

Generation of mice with mitochondrial dysfunction by introducing mouse mtDNA carrying a deletion into zygotes

J. Hayashi, I. Nonaka, A. Ogura, 2000, Nature Genetics.

Clinical and biochemical phenotype of the MELAS mutation

J. Hayashi, S. Miyabayashi, K. Tada, 1993, Journal of Inherited Metabolic Disease.

New Evidence Confirms That the Mitochondrial Bottleneck Is Generated without Reduction of Mitochondrial DNA Content in Early Primordial Germ Cells of Mice

H. Yonekawa, J. Hayashi, K. Abe, 2009, PLoS genetics.

Association of predicted pathogenic mutations in mitochondrial ND genes with distant metastasis in NSCLC and colon cancer

J. Hayashi, H. Nagase, K. Takenaga, 2017, Scientific Reports.

A Novel MitoNEET Ligand, TT01001, Improves Diabetes and Ameliorates Mitochondrial Function in db/db Mice

J. Hayashi, K. Nakada, M. Kainoh, 2015, The Journal of Pharmacology and Experimental Therapeutics.

Respiratory chain deficiency slows down cell‐cycle progression via reduced ROS generation and is associated with a reduction of p21CIP1/WAF1

J. Hayashi, D. Spitkovsky, R. Wiesner, 2006, Journal of cellular physiology.

New MT-ND6 and NDUFA1 mutations in mitochondrial respiratory chain disorders

Tetsuro Sakai, Yasushi Okazaki, Yutaka Nakachi, 2014, Annals of clinical and translational neurology.

Mitochondria-related male infertility

H. Yonekawa, J. Hayashi, Kayo Yoshida, 2006, Proceedings of the National Academy of Sciences.

Comprehensive application of an mtDsRed2-Tg mouse strain for mitochondrial imaging

H. Yonekawa, J. Hayashi, H. Shitara, 2011, Transgenic Research.

Global imaging of mitochondrial morphology in tissues using transgenic mice expressing mitochondrially targeted enhanced green fluorescent protein.

H. Yonekawa, J. Hayashi, H. Shitara, 2010, Experimental animals.

Interaction theory of mammalian mitochondria.

J. Hayashi, K. Nakada, K. Inoue, 2001, Biochemical and biophysical research communications.

Transmitochondrial mito-miceΔ and mtDNA mutator mice, but not aged mice, share the same spectrum of musculoskeletal disorders.

J. Hayashi, Michiko Suzuki, Kaori Ishikawa, 2015, Biochemical and biophysical research communications.

Normal mitochondrial respiratory function is essential for spatial remote memory in mice

H. Yonekawa, J. Hayashi, T. Miyakawa, 2008, Molecular Brain.

Association of predicted pathogenic mutations in mitochondrial ND genes with distant metastasis in NSCLC and colon cancer

J. Hayashi, H. Nagase, K. Takenaga, 2017, Scientific Reports.

Mitochondrial DNA Mutations in Mutator Mice Confer Respiration Defects and B-Cell Lymphoma Development

Y. Kikkawa, J. Hayashi, Hirotake Imanishi, 2013, PloS one.

Mitochondrial complex I activity is significantly decreased in a patient with maternally inherited type 2 diabetes mellitus and hypertrophic cardiomyopathy associated with mitochondrial DNA C3310T mutation: a cybrid study.

J. Hayashi, Y. Hattori, A. Sugiyama, 2006, Diabetes research and clinical practice.

Interleukin-33 enhances programmed oncosis of ST2L-positive low-metastatic cells in the tumour microenvironment of lung cancer

J. Hayashi, S. Nakae, K. Takenaga, 2016, Cell Death and Disease.

Corrigendum: Epigenetic regulation of the nuclear-coded GCAT and SHMT2 genes confers human age-associated mitochondrial respiration defects

M. Soda, H. Mano, J. Hayashi, 2015, Scientific Reports.

Polymorphisms of mitochondrial DNAs in Norway rats (Rattus norvegicus): Cleavage site variations and length polymorphism of restriction fragments

J. Hayashi, K. Moriwaki, Y. Tagashira, 2004, Molecular and General Genetics MGG.

Cytoplasmic transfer of platelet mtDNA from elderly patients with Parkinson's disease to mtDNA-less HeLa cells restores complete mitochondrial respiratory function.

S. Kuno, J. Hayashi, K. Nakada, 2001, Biochemical and biophysical research communications.

A mitochondrial DNA mutation cosegregates with the pathophysiological U wave.

J. Hayashi, M. Furutani, R. Matsuoka, 1999, Biochemical and biophysical research communications.

A novel defense system of mitochondria in mice and human subjects for preventing expression of mitochondrial dysfunction by pathogenic mutant mtDNAs.

J. Hayashi, T. Ono, K. Nakada, 2002, Mitochondrion.

Functional and morphological abnormalities of mitochondria in human cells containing mitochondrial DNA with pathogenic point mutations in tRNA genes.

Y. Kagawa, J. Hayashi, S. Ohta, 1994, The Journal of biological chemistry.

Relationship between mitochondrial DNA polymorphism and the individual differences in aerobic performance.

S. Kuno, J. Hayashi, M. Okada, 2001, The Japanese journal of physiology.

The effects of cytoplasmic transfer of mtDNA in relation to whole-body endurance performance.

S. Kuno, J. Hayashi, M. Okada, 2001, The Japanese journal of physiology.

A new mitochondrial DNA mutation at 14577 T/C is probably a major pathogenic mutation for maternally inherited type 2 diabetes.

J. Hayashi, J. Chen, T. Onaya, 2000, Diabetes.

Generation of trans-mitochondrial mice carrying homoplasmic mtDNAs with a missense mutation in a structural gene using ES cells.

H. Endo, J. Hayashi, S. Aizawa, 2006, Human molecular genetics.

Mitochondrial DNA with a Large-Scale Deletion Causes Two Distinct Mitochondrial Disease Phenotypes in Mice

J. Hayashi, K. Nakada, E. Ogasawara, 2013, G3: Genes, Genomes, Genetics.

Transmitochondrial mice as models for mitochondrial DNA-based diseases.

J. Hayashi, K. Nakada, 2011, Experimental animals.

Mice deficient in the Shmt2 gene have mitochondrial respiration defects and are embryonic lethal

H. Yonekawa, J. Hayashi, H. Shitara, 2018, Scientific Reports.

Accumulation of pathogenic DeltamtDNA induced deafness but not diabetic phenotypes in mito-mice.

H. Yonekawa, J. Hayashi, H. Sone, 2004, Biochemical and biophysical research communications.

A patient with type 2 diabetes mellitus associated with mutations in calcium sensing receptor gene and mitochondrial DNA.

J. Hayashi, J. Chen, T. Onaya, 2000, Biochemical and biophysical research communications.

Mitochondrial functional complementation in mitochondrial DNA-based diseases.

J. Hayashi, K. Nakada, A. Sato, 2009, The international journal of biochemistry & cell biology.

Transmitochondrial mice as models for primary prevention of diseases caused by mutation in the tRNALys gene

J. Hayashi, K. Takenaga, K. Nakada, 2014, Proceedings of the National Academy of Sciences.

Two different molecular types of rat mitochondrial DNAs.

O. Gotoh, H. Yonekawa, J. Hayashi, 1978, Biochemical and biophysical research communications.

Mito-mice: animal models for mitochondrial DNA-based diseases.

J. Hayashi, K. Nakada, K. Inoue, 2001, Seminars in cell & developmental biology.

Production of mitochondrial DNA transgenic mice using zygotes.

J. Hayashi, A. Ogura, K. Inoue, 2002, Methods.

Length of polymorphisms of restriction fragments of rat mitochondrial DNAs.

O. Gotoh, J. Hayashi, Y. Tagashira, 1981, Biochemical and biophysical research communications.

A high mutation load of m.14597A>G in MT-ND6 causes Leigh syndrome

Y. Okazaki, J. Hayashi, A. Ohtake, 2021, Scientific Reports.

Generation of trans‐mitochondrial mito‐mice by the introduction of a pathogenic G13997A mtDNA from highly metastatic lung carcinoma cells

H. Yonekawa, J. Hayashi, H. Shitara, 2010, FEBS letters.

Aberrant RNA processing contributes to the pathogenesis of mitochondrial diseases in trans-mitochondrial mouse model carrying mitochondrial tRNALeu(UUR) with a pathogenic A2748G mutation

J. Hayashi, D. Kang, Kaori Ishikawa, 2022, Nucleic Acids Research.

Mouse somatic mutation orthologous to MELAS A3302G mutation in the mitochondrial tRNA(Leu(UUR)) gene confers respiration defects.

H. Yonekawa, J. Hayashi, Kaori Ishikawa, 2015, Biochemical and biophysical research communications.

Enhanced glycolysis induced by mtDNA mutations does not regulate metastasis

J. Hayashi, Kaori Ishikawa, K. Takenaga, 2008, FEBS letters.

Over-expression of Tfam improves the mitochondrial disease phenotypes in a mouse model system.

H. Yonekawa, J. Hayashi, H. Masaki, 2010, Biochemical and biophysical research communications.

A novel mutation in TAZ causes mitochondrial respiratory chain disorder without cardiomyopathy

Y. Okazaki, J. Hayashi, A. Takeda, 2017, Journal of Human Genetics.

Mitochondrial respiration defects modulate differentiation but not proliferation of hematopoietic stem and progenitor cells

J. Hayashi, H. Miyoshi, K. Nakada, 2010, FEBS letters.

Mutant mtDNA at 1555 A to G in 12S rRNA gene and hypersusceptibility of mitochondrial translation to streptomycin can be co-transferred to rho 0 HeLa cells.

J. Hayashi, D. Takai, Yoshitomo Oka, 1996, Biochemical and biophysical research communications.

Selection of rodent species appropriate for mtDNA transfer to generate transmitochondrial mito-mice expressing mitochondrial respiration defects.

J. Hayashi, Hirotake Imanishi, K. Nakada, 2014, Experimental animals.

Mitochondrial functional complementation in mitochondrial DNA-based diseases.

J. Hayashi, K. Nakada, A. Sato, 2009, The international journal of biochemistry & cell biology.

A somatic T15091C mutation in the Cytb gene of mouse mitochondrial DNA dominantly induces respiration defects.

J. Hayashi, Kaori Ishikawa, K. Nakada, 2015, Biochemical and biophysical research communications.

G7731A mutation in mouse mitochondrial tRNALys regulates late-onset disorders in transmitochondrial mice.

H. Yonekawa, J. Hayashi, Kaori Ishikawa, 2015, Biochemical and biophysical research communications.

Presence of interaction but not complementation between human mtDNAs carrying different mutations within a tRNA(Leu(UUR)) gene.

J. Hayashi, T. Ono, K. Nakada, 2004, Biochemical and biophysical research communications.

Determination of normal ranges of mitochondrial respiratory activities by mtDNA transfer from 54 Human subjects to mtDNA-less HeLa cells for identification of the pathogenicities of mutated mtDNAs.

S. Kuno, J. Hayashi, Y. Momiyama, 2004, Journal of biochemistry.

Isolation of Mitochondrial DNA-less Mouse Cell Lines and Their Application for Trapping Mouse Synaptosomal Mitochondrial DNA with Deletion Mutations*

Y. Kagawa, J. Hayashi, E. Ségal-Bendirdjian, 1997, The Journal of Biological Chemistry.