C. Rada

发表

The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2 −/− ung −/− mice

M. Neuberger, K. Xue, C. Rada, 2006, The Journal of experimental medicine.

DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis

M. Stratton, P. Campbell, L. Stebbings, 2013, eLife.

The topography of mutational processes in breast cancer genomes

E. Birney, A. Børresen-Dale, M. Stratton, 2016, Nature Communications.

Active demethylation in mouse zygotes involves cytosine deamination and base excision repair

W. Reik, C. Rada, W. Dean, 2013, Epigenetics & Chromatin.

Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots.

C. Milstein, M. Neuberger, A. G. Betz, 1993, Proceedings of the National Academy of Sciences of the United States of America.

CTNNBL1 Is a Novel Nuclear Localization Sequence-binding Protein That Recognizes RNA-splicing Factors CDC5L and Prp31

M. Neuberger, C. Rada, Benjamin J M Taylor, 2011, The Journal of Biological Chemistry.

The AKV Murine Leukemia Virus Is Restricted and Hypermutated by Mouse APOBEC3

M. Neuberger, C. Rada, Marc-André Langlois, 2009, Journal of Virology.

Memory in the B-cell compartment: antibody affinity maturation.

C. Milstein, M. Neuberger, C. Rada, 2000, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1

G. K. Sandve, T. Rognes, L. Alexandrov, 2017, Scientific Reports.

Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin α

Christopher M Johnson, M. Neuberger, Roger L. Williams, 2013, FEBS letters.

Epigenetics: Monoallelic Expression in the Immune System

A. Ferguson-Smith, C. Rada, 2002, Current Biology.

Apobec2 deficiency causes mitochondrial defects and mitophagy in skeletal muscle

C. Rada, F. Yoshizawa, H. Iida, 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The uracil-DNA glycosylase UNG protects the fitness of normal and cancer B cells expressing AID

N. Johnson, R. Verdun, C. Rada, 2020, NAR cancer.

Mouse APOBEC3 Restricts Friend Leukemia Virus Infection and Pathogenesis In Vivo

M. Neuberger, C. Rada, M. Miyazawa, 2008, Journal of Virology.

A high-throughput assay for DNA deaminases.

M. Wang, M. Neuberger, C. Rada, 2011, Methods in molecular biology.

Concerted evolution of class I genes in the major histocompatibility complex of murine rodents.

P. Parham, C. Rada, S. Powis, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Enhancement of Adeno-Associated Virus-Mediated Gene Therapy Using Hydroxychloroquine in Murine and Human Tissues

K. Xue, C. Rada, R. MacLaren, 2019, Molecular therapy. Methods & clinical development.

Correlation of somatic hypermutation specificity and A-T base pair substitution errors by DNA polymerase η during copying of a mouse immunoglobulin κ light chain transgene

T. Kunkel, C. Rada, I. Rogozin, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Mutation and selection during the secondary response to 2-phenyloxazolone.

C. Milstein, C. Rada, E. Gherardi, 1991, Proceedings of the National Academy of Sciences of the United States of America.

microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells.

Anton J. Enright, Allan Bradley, Sam Bunting, 2007, Immunity.

Automated detection of point mutations using fluorescent sequence trace subtraction.

R Staden, J K Bonfield, J. Bonfield, 1998, Nucleic acids research.

Uracil excision by endogenous SMUG1 glycosylase promotes efficient Ig class switching and impacts on A:T substitutions during somatic mutation

M. Neuberger, C. Rada, Felix A. Dingler, 2014, European journal of immunology.

Immunoglobulin Isotype Switching Is Inhibited and Somatic Hypermutation Perturbed in UNG-Deficient Mice

D. Barnes, M. Neuberger, C. Rada, 2002, Current Biology.

Active RNAP pre-initiation sites are highly mutated by cytidine deaminases in yeast, with AID targeting small RNA genes

C. Rada, Benjamin J M Taylor, Yee-Ling Wu, 2014, eLife.

The cytoplasmic AID complex.

M. Neuberger, C. Rada, J. Häsler, 2012, Seminars in immunology.

REG-γ associates with and modulates the abundance of nuclear activation-induced deaminase

M. Neuberger, C. Rada, Y. Uchimura, 2011, The Journal of experimental medicine.

Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung−/−Msh2−/− mice

M. Neuberger, C. Rada, Felix A. Dingler, 2012, Nucleic acids research.

Germline ablation of SMUG 1 DNA glycosylase causes loss of 5-hydroxymethyluracil-and UNG-backup uracil-excision activities and increases cancer predisposition of Ung / Msh 2 / mice

M. Neuberger, C. Rada, Felix A. Dingler, 2012 .

The dependence of Ig class-switching on the nuclear export sequence of AID likely reflects interaction with factors additional to Crm1 exportin

M. Neuberger, C. Rada, Benjamin J M Taylor, 2010, European journal of immunology.

Altering the spectrum of immunoglobulin V gene somatic hypermutation by modifying the active site of AID

M. Neuberger, C. Rada, Meng Wang, 2010, The Journal of experimental medicine.

AID up-mutants isolated using a high-throughput screen highlight the immunity/cancer balance limiting DNA deaminase activity

M. Wang, M. Neuberger, C. Rada, 2009, Nature Structural &Molecular Biology.

The stability of AID and its function in class-switching are critically sensitive to the identity of its nuclear-export sequence

M. Neuberger, C. Rada, R. Geisberger, 2009, Proceedings of the National Academy of Sciences.

Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1.

M. Neuberger, K. Xue, C. Rada, 2008, Molecular cell.

SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repair

M. Neuberger, C. Rada, J. D. Di Noia, 2006, The EMBO journal.

Somatic hypermutation at A·T pairs: polymerase error versus dUTP incorporation

Zizhen Yang, Javier M. Di Noia, M. Neuberger, 2005, Nature Reviews Immunology.

Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation.

M. Neuberger, C. Rada, J. D. Di Noia, 2004, Molecular cell.

Comparison of the differential context-dependence of DNA deamination by APOBEC enzymes: correlation with mutation spectra in vivo.

Reuben S Harris, M. Neuberger, C. Rada, 2004, Journal of molecular biology.

AID-GFP chimeric protein increases hypermutation of Ig genes with no evidence of nuclear localization

C. Milstein, C. Rada, J. Jarvis, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination

C. Milstein, M. Neuberger, C. Rada, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting.

C. Milstein, M. Neuberger, C. Rada, 1998, Immunity.

The targeting of somatic hypermutation.

C. Milstein, M. Neuberger, N. Klix, 1996, Seminars in immunology.

Mutagenesis by AID: Being in the Right Place at the Right Time

C. Rada, 2015, PLoS genetics.

Somatic hypermutation: activation-induced deaminase for C/G followed by polymerase η for A/T

M. Neuberger, C. Rada, Cristina Rada, 2007, The Journal of experimental medicine.

The mechanism of somatic hypermutation at A·T pairs remains an open question

M. Neuberger, C. Rada, J. Noia, 2005, Nature Reviews Immunology.

Cytoplasmic activation-induced cytidine deaminase (AID) exists in stoichiometric complex with translation elongation factor 1α (eEF1A)

M. Neuberger, C. Rada, J. Häsler, 2011, Proceedings of the National Academy of Sciences.

Mice Deficient in APOBEC2 and APOBEC3

Wolf Reik, M. Neuberger, W. Reik, 2005, Molecular and Cellular Biology.

The intrinsic hypermutability of antibody heavy and light chain genes decays exponentially

César Milstein, C. Milstein, C. Rada, 2001, The EMBO journal.

Monitoring and interpreting the intrinsic features of somatic hypermutation

César Milstein, C. Milstein, M. Neuberger, 1998, Immunological reviews.

Aicardi–Goutières Syndrome associated mutations of RNase H2B impair its interaction with ZMYM3 and the CoREST histone-modifying complex

C. Rada, Alexander Shapson-Coe, B. Valeiras, 2019, PloS one.

The 5′ hypermutation boundary of x chains is independent of local and neighbouring sequences and related to the distance from the initiation of transcription

C. Milstein, J. Yélamos, C. Rada, 1997, European journal of immunology.

3 – The maturation of the antibody response

C. Milstein, C. Rada, 1995 .

The 5′ boundary of somatic hypermutation in a Vχ gene is in the leader intron

C. Milstein, C. Rada, Á. González-Fernández, 1994 .

Directed evolution of human scFvs in DT40 cells

C. Rada, J. Sale, Cristina Rada, 2015, Protein engineering, design & selection : PEDS.

Intrinsic transcriptional heterogeneity in B cells controls early class switching to IgE

Sarah A Teichmann, Michael J. T. Stubbington, S. Teichmann, 2017, The Journal of experimental medicine.

Harnessing mutation: The best of two worlds

C. Rada, S. Conticello, 2016, Science.

In vivo and in vitro studies of immunoglobulin gene somatic hypermutation.

C. Milstein, M. Neuberger, C. Rada, 2001, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

Early-onset lymphoma and extensive embryonic apoptosis in two domain-specific Fen1 mice mutants.

M. Neuberger, L. Meza-Zepeda, C. Rada, 2008, Cancer research.

ATMIN Is Required for Maintenance of Genomic Stability and Suppression of B Cell Lymphoma

Fengtang Yang, C. Rada, J. Loizou, 2011, Cancer cell.

CTNNBL1 facilitates the association of CWC15 with CDC5L and is required to maintain the abundance of the Prp19 spliceosomal complex

C. Rada, M. Skehel, Anita Chandra, 2015, Nucleic acids research.

Affinity maturation leads to differential expression of multiple copies of a κ light-chain transgene

C. Milstein, C. Rada, J. Jarvis, 1993, Nature.

Deficiency in APOBEC2 Leads to a Shift in Muscle Fiber Type, Diminished Body Mass, and Myopathy

M. Neuberger, C. Rada, H. Probst, 2009, The Journal of Biological Chemistry.

The 5' boundary of somatic hypermutation in a V kappa gene is in the leader intron.

C. Milstein, C. Rada, Á. González-Fernández, 1994, European journal of immunology.

Deficiency in spliceosome-associated factor CTNNBL1 does not affect ongoing cell cycling but delays exit from quiescence and results in embryonic lethality in mice

M. Neuberger, S. Andrews, C. Rada, 2013, Cell cycle.

Affinity maturation leads to differential expression of multiple copies of a κ light-chain transgene

C. Milstein, C. Rada, J. Jarvis, 1995, Nature.

Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1

G. K. Sandve, L. Alexandrov, C. Rada, 2017, Scientific Reports.

Altering the spectrum of immunoglobulin V gene somatic hypermutation by modifying the active site of AID

M. Neuberger, C. Rada, Meng Wang, 2010, The Journal of experimental medicine.

The topography of mutational processes in breast cancer genomes

E. Birney, A. Børresen-Dale, M. J. van de Vijver, 2016, Nature Communications.

AID and RPA: PKA makes the connection local

C. Rada, 2009, Nature Immunology.

Molecular fine-tuning of affinity maturation in germinal centers.

C. Rada, Yee-Ling Wu, 2016, The Journal of clinical investigation.

Mouse APOBEC3 Restricts Friend Leukemia Virus Infection and Pathogenesis In Vivo

M. Neuberger, C. Rada, M. Miyazawa, 2008, Journal of Virology.

Uracil excision by endogenous SMUG1 glycosylase promotes efficient Ig class switching and impacts on A:T substitutions during somatic mutation

M. Neuberger, C. Rada, T. Kuijpers, 2014, European journal of immunology.

The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2 −/− ung −/− mice

M. Neuberger, C. Rada, Kanmin Xue, 2006, The Journal of experimental medicine.