D. Siegel

发表

Caenorhabditis elegans selects distinct crawling and swimming gaits via dopamine and serotonin

M. Brauner, A. Gottschalk, K. Erbguth, 2011, Proceedings of the National Academy of Sciences.

Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis.

C. Donaldson, A. Saghatelian, D. Siegel, 2018, Cell metabolism.

Synthesis of (+)-complanadine A, an inducer of neurotrophic factor excretion.

Abram Axelrod, D. Siegel, Changxia Yuan, 2010, Journal of the American Chemical Society.

Syntheses of xanthofulvin and vinaxanthone, natural products enabling spinal cord regeneration.

Abram Axelrod, D. Siegel, Katherine Zlotkowski, 2013, Angewandte Chemie.

Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics

Erika L. Flannery, Victoria C. Corey, Yingyao Zhou, 2018, Science.

Discovery of FAHFA-Containing Triacylglycerols and Their Metabolic Regulation.

A. Saghatelian, D. Siegel, B. Kahn, 2019, Journal of the American Chemical Society.

Preparation of phenols by phthaloyl peroxide–mediated oxidation of arenes

D. Siegel, Anders M. Eliasen, Changxia Yuan, 2014, Nature Protocols.

Dearomatization Reactions Using Phthaloyl Peroxide.

D. Siegel, Mitchell P. Christy, Anders M. Eliasen, 2015, Organic letters.

Stereochemistry of Endogenous Palmitic Acid Ester of 9-Hydroxystearic Acid and Relevance of Absolute Configuration to Regulation.

A. Saghatelian, D. Siegel, B. Kahn, 2017, Journal of the American Chemical Society.

Distinct biological activities of isomers from several families of branched fatty acid esters of hydroxy fatty acids (FAHFAs)

A. Saghatelian, D. Siegel, B. Kahn, 2021, Journal of lipid research.

Total Synthesis of Celastrol, Development of a Platform to Access Celastroid Natural Products.

D. Siegel, Andrew M Camelio, T. Johnson, 2015, Journal of the American Chemical Society.

1 Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-tetradecanoylphorbol-13-acetate

T. Slaga, D. Siegel, J. DiGiovanni, 2015 .

Linoleic acid esters of hydroxy linoleic acids are anti-inflammatory lipids found in plants and mammals

A. Saghatelian, D. Siegel, Tina Chang, 2019, The Journal of Biological Chemistry.

Semaphorin3a Promotes Advanced Diabetic Nephropathy

D. Siegel, M. Kashgarian, G. Moeckel, 2014, Diabetes.

A Faster Protocol for Endogenous FAHFA Measurements

D. Siegel, B. Kahn, L. Ohlsson, 2018 .

Discovery of an IKK2 Site that Allosterically Controls Its Activation

Rommie E. Amaro, D. Siegel, G. Ghosh, 2021, bioRxiv.

PAHSAs attenuate immune responses and promote β cell survival in autoimmune diabetic mice.

A. Saghatelian, D. Mathis, D. Siegel, 2019, The Journal of clinical investigation.

Total Synthesis of Micrococcin P1 through Scalable Thiazole Forming Reactions of Cysteine Derivatives and Nitriles.

D. Siegel, A. T. Nelson, Mitchell P. Christy, 2020, Organic letters.

Design and Synthesis of Purine Connected Piperazine Derivatives as Novel Inhibitors of Mycobacterium tuberculosis.

D. Sriram, D. Siegel, K. P. Rao, 2020, Bioorganic & medicinal chemistry letters.

1 Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum 2 intracellular secretory pathway 3

Gregory M. Goldgof, Andrea L. Cheung, E. Winzeler, 2019 .

Effects of Eupalinilide E and UM171, alone and in combination on cytokine stimulated ex-vivo expansion of human cord blood hematopoietic stem cells.

D. Siegel, H. Broxmeyer, S. Cooper, 2020, Blood cells, molecules & diseases.

Synthesis of Eupalinilide E, a Promoter of Human Hematopoietic Stem and Progenitor Cell Expansion.

J. Shen, T. Rana, D. Siegel, 2016, Journal of the American Chemical Society.

A class of anti-inflammatory lipids decrease with aging in the central nervous system

C. Donaldson, J. Vaughan, A. Saghatelian, 2022, Nature Chemical Biology.

Efficacy, metabolism and pharmacokinetics of Ro 15-5458, a forgotten schistosomicidal 9-acridanone hydrazone.

J. Keiser, D. Siegel, C. Caffrey, 2020, The Journal of antimicrobial chemotherapy.

Vinaxanthone inhibits Semaphorin3A induced axonal growth cone collapse in embryonic neurons but fails to block its growth promoting effects on adult neurons

D. Siegel, V. Guaiquil, Evguenia Ivakhnitskaia, 2021, Scientific Reports.

Synthesis of the 26-Membered Core of Thiopeptide Natural Products by Scalable Thiazole-Forming Reactions of Cysteine Derivatives and Nitriles

D. Siegel, Mitchell P. Christy, T. Johnson, 2020, Synthesis.

Studies directed toward the synthesis of terreulactone A: rapid construction of the A, B, C rings.

D. Siegel, S. Danishefsky, Haibo Liu, 2006, Organic letters.

Synthesis of chemically edited derivatives of the endogenous regulator of inflammation 9-PAHSA

A. Saghatelian, D. Siegel, Tina Chang, 2019, The Journal of Antibiotics.

Mechanistic insights gained from cell and molecular analysis of the neuroprotective potential of bioactive natural compounds in an immortalized hippocampal cell line

D. Prough, D. Siegel, S. Widen, 2022, PloS one.

Pan-active imidazolopiperazine antimalarials target the falciparum intracellular secretory pathway.

Gregory M. Goldgof, Andrea L. Cheung, E. Winzeler, 2020 .

Employing modular polyketide synthase ketoreductases as biocatalysts in the preparative chemoenzymatic syntheses of diketide chiral building blocks.

D. Siegel, A. Keatinge-Clay, Jianting Zheng, 2011, Chemistry & biology.

Syntheses of (+)-complanadine A and lycodine derivatives by regioselective [2 + 2 + 2] cycloadditions.

D. Siegel, Changxia Yuan, Chih-Tsung Chang, 2013, The Journal of organic chemistry.

A protocol to generate phthaloyl peroxide in flow for the hydroxylation of arenes.

D. Siegel, Anders M. Eliasen, Changxia Yuan, 2014, Organic letters.

Global chemical effects of the microbiome include new bile-acid conjugations

Julie C. Lumeng, Rob Knight, Mingxun Wang, 2020, Nature.

Cascade reactions leading to the mechanism of action of vinaxanthone and xanthofulvin, natural products that drive nerve repair

R. Abagyan, Abram Axelrod, D. Siegel, 2018, Tetrahedron.

Differentiation of nonconventional "carbanions"-the total synthesis of nemorosone and clusianone.

D. Siegel, S. Danishefsky, C. Tsukano, 2007, Angewandte Chemie.

Comprehensive Organic Name Reactions and Reagents, Volume 1−3

D. Siegel, 2010 .

A Convergent Enantioselective Route to Structurally Diverse 6-Deoxytetracycline Antibiotics

Andrew G Myers, C. Lerner, D. Siegel, 2005, Science.

Synthesis of (-)-tetracycline.

D. Siegel, A. Myers, M. Charest, 2005, Journal of the American Chemical Society.

Directing Stem Cell Fate: The Synthetic Natural Product Connection.

D. Siegel, T. Johnson, 2017, Chemical reviews.

Synthesis of a broad array of highly functionalized, enantiomerically pure cyclohexanecarboxylic acid derivatives by microbial dihydroxylation of benzoic acid and subsequent oxidative and rearrangement reactions.

D. Siegel, A. Myers, D. Buzard, 2001, Organic letters.

Total syntheses of polycyclic polyp renylated acylphloroglucinols

D. Siegel, S. Danishefsky, C. Tsukano, 2010 .

Total Synthesis of (±)-Garsubellin A

D. Siegel, S. Danishefsky, 2005 .

Stereochemistry of Linoleic Acid Esters of Hydroxy Linoleic Acids.

J. Rizo, A. Saghatelian, D. Siegel, 2019, Organic letters.

Computational and Experimental Studies of Phthaloyl Peroxide-Mediated Hydroxylation of Arenes Yield a More Reactive Derivative, 4,5-Dichlorophthaloyl Peroxide.

D. Siegel, K. Houk, Anders M. Eliasen, 2015, The Journal of organic chemistry.

Hydroxyl-directed cyclizations of 1,6-enynes.

D. Siegel, T. Barton, Travis W. Shaw, 2011, Organic letters.

Synthetic Route Development for the Laboratory Preparation of Eupalinilide E.

D. Siegel, Matthew R. Chin, T. Johnson, 2017, The Journal of organic chemistry.

Complanadine A, a selective agonist for the Mas-related G protein-coupled receptor X2.

D. Siegel, T. Johnson, 2014, Bioorganic & medicinal chemistry letters.

Synthesis and reaction of phthaloyl peroxide derivatives, potential organocatalysts for the stereospecific dihydroxylation of alkenes

Abram Axelrod, D. Siegel, Michael C. Varela, 2011 .

Metal-free oxidation of aromatic carbon–hydrogen bonds through a reverse-rebound mechanism

K. Houk, D. Siegel, Yong Liang, 2013, Nature.

A robust platform for the synthesis of new tetracycline antibiotics.

C. Lerner, D. Siegel, P. Wright, 2008, Journal of the American Chemical Society.

In Vitro Efficacy of Ebselen and BAY 11-7082 Against Naegleria fowleri

D. Siegel, J. McKerrow, A. Debnath, 2018, Front. Microbiol..

A Synthesis-Based Reverse Metabolomics Approach for the Discovery of Chemical Structures from Humans and Animals.

Emily C. Gentry, Allegra T. Aron, D. Plichta, 2021 .

Expedited access to vinaxanthone and chemically edited derivatives possessing neuronal regenerative effects through ynone coupling reactions.

Abram Axelrod, D. Siegel, Katherine Zlotkowski, 2015, ACS chemical neuroscience.

New Antiretrovirals for HIV and Antivirals for HBV

D. Siegel, W. Tse, M. Mish, 2017 .

Biomimetic syntheses of the neurotrophic natural products caryolanemagnolol and clovanemagnolol.

D. Siegel, Travis W. Shaw, Xu Cheng, 2010, Organic letters.

Synthesis of oxygenated oleanolic and ursolic acid derivatives with anti-inflammatory properties.

D. Siegel, J. DiGiovanni, A. T. Nelson, 2015, Bioorganic & medicinal chemistry letters.

ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids

A. Saghatelian, R. Zechner, D. Siegel, 2022, Nature.

PAHSAs enhance hepatic and systemic insulin sensitivity through direct and indirect mechanisms.

A. Saghatelian, D. Siegel, P. Zhou, 2019, The Journal of clinical investigation.

Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics

Victoria C. Corey, Yingyao Zhou, E. Winzeler, 2017, Science.

Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway

Gregory M. Goldgof, Andrea L. Cheung, E. Winzeler, 2019, Nature Communications.

Gut bacteria responding to dietary change encode sialidases that exhibit preference for red meat-associated carbohydrates

A. Varki, D. Siegel, G. Chang, 2019, Nature Microbiology.

Small‐Molecule‐Mediated Axonal Branching in Caenorhabditis elegans

J. Pierce-Shimomura, D. Siegel, Katherine Zlotkowski, 2013, Chembiochem : a European journal of chemical biology.

Neuronal growth promoting sesquiterpene-neolignans; syntheses and biological studies.

C. Schmidt, D. Siegel, Z. Khaing, 2012, Organic & biomolecular chemistry.

Hippocampal and cortical neuronal growth mediated by the small molecule natural product clovanemagnolol.

C. Schmidt, D. Siegel, Z. Khaing, 2011, Bioorganic & medicinal chemistry letters.

Metal-Binding Pharmacophore Library Yields the Discovery of a Glyoxalase 1 Inhibitor.

Seth M. Cohen, A. Palmer, D. Siegel, 2019, Journal of medicinal chemistry.

Chemical Impacts of the Microbiome Across Scales Reveal Novel Conjugated Bile Acids

Rob Knight, Mingxun Wang, Pieter C. Dorrestein, 2019, bioRxiv.

Evaluation of pentacyclic triterpenes found in Perilla frutescens for inhibition of skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate

T. Slaga, D. Siegel, J. DiGiovanni, 2015, Oncotarget.

Selective inactivation of a human neuronal silencing phosphatase by a small molecule inhibitor.

Eun Jeong Cho, Yan Zhang, D. Siegel, 2011, ACS chemical biology.

Faster Protocol for Endogenous Fatty Acid Esters of Hydroxy Fatty Acid (FAHFA) Measurements.

A. Saghatelian, D. Siegel, B. Kahn, 2018, Analytical chemistry.

Open-source discovery of chemical leads for next-generation chemoprotective antimalarials

Manuel Llinás, Yingyao Zhou, David A. Fidock, 2018, Science.

Small‐Molecule Mechanism of Action Studies in Caenorhabditis elegans

Aurpon W. Mitra, D. Siegel, Katherine Zlotkowski, 2013, Chembiochem : a European journal of chemical biology.

Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate

T. Slaga, D. Siegel, J. DiGiovanni, 2015, Cancer Prevention Research.

Total synthesis of garsubellin A.

D. Siegel, S. Danishefsky, 2005, Journal of the American Chemical Society.

Short Synthesis of a Broadly Reactive, Cell Permeable Serine Hydrolase Fluorophosphonate-Alkyne Probe.

D. Siegel, Srihari Konduri, Joshua Schweer, 2023, Bioorganic & Medicinal Chemistry Letters.