E. Hurt

发表

The nuclear pore complex: understanding its function through structural insight

M. Beck, E. Hurt, Martin Beck, 2016, Nature Reviews Molecular Cell Biology.

Molecular architecture of the inner ring scaffold of the human nuclear pore complex

J. Briggs, M. Beck, E. Hurt, 2016, Science.

Linker Nups connect the nuclear pore complex inner ring with the outer ring and transport channel

E. Hurt, Roman Teimer, Jessica Fischer, 2015, Nature Structural &Molecular Biology.

Driving ribosome assembly.

E. Hurt, D. Kressler, J. Baßler, 2010, Biochimica et biophysica acta.

Developing genetic tools to exploit Chaetomium thermophilum for biochemical analyses of eukaryotic macromolecular assemblies

B. Chait, E. Hurt, J. Fernandez-Martinez, 2016, Scientific Reports.

Eukaryotic ribosome assembly, transport and quality control

V. G. Panse, E. Hurt, C. Peña, 2017, Nature Structural &Molecular Biology.

Structure and Assembly of the Nup84p Complex

Ueli Aebi, Helena Santos-Rosa, Ed Hurt, 2000, The Journal of cell biology.

Nuclear export of ribosomal 60S subunits by the general mRNA export receptor Mex67-Mtr2.

Ed Hurt, E. Hurt, A. Köhler, 2007, Molecular cell.

The nuclear pore complex

E. Hurt, 1993, FEBS letters.

Structural basis of the nic96 subcomplex organization in the nuclear pore channel.

Ed Hurt, Ruth Kunze, I. Vetter, 2008, Molecular cell.

Exporting RNA from the nucleus to the cytoplasm

Ed Hurt, E. Hurt, A. Köhler, 2007, Nature Reviews Molecular Cell Biology.

Insight into Structure and Assembly of the Nuclear Pore Complex by Utilizing the Genome of a Eukaryotic Thermophile

Peer Bork, Vera van Noort, Manimozhiyan Arumugam, 2011, Cell.

An integrated approach for genome annotation of the eukaryotic thermophile Chaetomium thermophilum

P. Bork, A. Gavin, T. Doerks, 2014, Nucleic acids research.

SAGA interacting factors confine sub-diffusion of transcribed genes to the nuclear envelope

Jean-Christophe Olivo-Marin, Christophe Zimmer, Annick Lesne, 2006, Nature.

Cotranscriptional recruitment of the serine-arginine-rich (SR)-like proteins Gbp2 and Hrb1 to nascent mRNA via the TREX complex

Ed Hurt, E. Hurt, R. Reed, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Identification and Characterization of a Novel RanGTP-binding Protein in the Yeast Saccharomyces cerevisiae *

M. Künzler, P. Legrain, F. Bischoff, 2003, The Journal of Biological Chemistry.

Structure of the C-terminal FG-nucleoporin binding domain of Tap/NXF1

E. Hurt, M. Stewart, D. Neuhaus, 2002, Nature Structural Biology.

Consistent mutational paths predict eukaryotic thermostability

P. Bork, M. Arumugam, D. Mende, 2013, BMC Evolutionary Biology.

Rlp7p is associated with 60S preribosomes, restricted to the granular component of the nucleolus, and required for pre-rRNA processing

E. Petfalski, D. Tollervey, E. Hurt, 2002, The Journal of cell biology.

The nucle(ol)ar Tif6p and Efl1p are required for a late cytoplasmic step of ribosome synthesis.

E. Hurt, D. Lafontaine, A. Camasses, 2001, Molecular cell.

Two structurally distinct domains of the nucleoporin Nup170 cooperate to tether a subset of nucleoporins to nuclear pores

B. Böttcher, E. Hurt, Philipp Stelter, 2009, The Journal of cell biology.

Cselp functions as the nuclear export receptor for importin α in yeast

M. Künzler, E. Hurt, 1998 .

Transfer RNA biogenesis: A visa to leave the nucleus

E. Hurt, G. Simos, 1999, Current Biology.

Complex Formation between Tap and p15 Affects Binding to FG-repeat Nucleoporins and Nucleocytoplasmic Shuttling*

E. Hurt, Y. Yoneda, J. Katahira, 2002, The Journal of Biological Chemistry.

Mammalian nuclei contain foci which are highly enriched in components of the pre‐mRNA splicing machinery.

R. Pepperkok, D. Tollervey, P. Zamore, 1991, The EMBO journal.

Nucleolar KKE/D repeat proteins Nop56p and Nop58p interact with Nop1p and are required for ribosome biogenesis

D. Tollervey, E. Hurt, T. Gautier, 1997, Molecular and cellular biology.

A Novel In Vivo Assay Reveals Inhibition of Ribosomal Nuclear Export in Ran-Cycle and Nucleoporin Mutants

D. Tollervey, E. Hurt, S. Hannus, 1999, The Journal of cell biology.

The crystal structure of Ebp1 reveals a methionine aminopeptidase fold as binding platform for multiple interactions

E. Hurt, I. Sinning, Bettina Bradatsch, 2007, FEBS letters.

Visualizing the Assembly Pathway of Nucleolar Pre-60S Ribosomes

E. Hurt, R. Beckmann, I. Sinning, 2017, Cell.

Dominant Rio 1 kinase / ATPase catalytic mutant induces trapping of late pre-40 S biogenesis factors in 80 S-like ribosomes

E. Hurt, Sébastien Ferreira-Cerca, I. Kiburu, 2014 .

JCB_201408111 1..18

Sarah A. Clark, D. Tollervey, E. Hurt, 2015 .

A network of assembly factors is involved in remodeling rRNA elements during preribosome maturation

Sarah A. Clark, D. Tollervey, E. Hurt, 2015, The Journal of cell biology.

The AAA-ATPase Rea1 drives removal of biogenesis factors during multiple stages of 60S ribosome assembly.

E. Hurt, J. Baßler, M. Thoms, 2010, Molecular cell.

Cell biology: Arrest by ribosome

E. Hurt, Sébastien Ferreira-Cerca, 2009, Nature.

Mpp10 represents a platform for the interaction of multiple factors within the 90S pre-ribosome

E. Hurt, Ruth Kunze, G. Stier, 2017, PloS one.

Mpp10 represents a platform for the interaction of multiple factors within the 90S pre-ribosome

E. Hurt, Ruth Kunze, G. Stier, 2017, PloS one.

Evolutionary conservation of the human nucleolar protein fibrillarin and its functional expression in yeast

D. Tollervey, M. Carmo-Fonseca, E. Hurt, 1991, The Journal of cell biology.

Structural basis for the molecular evolution of SRP-GTPase activation by protein

P. Grudnik, E. Hurt, Nico Kümmerer, 2011, Nature Structural &Molecular Biology.

Linking gene regulation to mRNA production and export.

Ed Hurt, E. Hurt, S. Rodríguez-Navarro, 2011, Current opinion in cell biology.

Global Transcriptome Characterization and Assembly of Thermophilic Ascomycete Chaetomium thermophilum

E. Hurt, M. Brunner, N. Kellner, 2019, bioRxiv.

Pus1p-dependent tRNA Pseudouridinylation Becomes Essential When tRNA Biogenesis Is Compromised in Yeast*

E. Hurt, G. Simos, F. Lecointe, 2001, The Journal of Biological Chemistry.

Nuclear transport

E. Hurt, E. Fabre, 1997, Science.

A Puzzle of Life: Crafting Ribosomal Subunits.

E. Hurt, D. Kressler, J. Baßler, 2017, Trends in biochemical sciences.

Coordinated Ribosomal ITS2 RNA Processing by the Las1 Complex Integrating Endonuclease, Polynucleotide Kinase, and Exonuclease Activities.

E. Hurt, D. Flemming, Lisa Gasse, 2015, Molecular cell.

Eukaryotic Ribosome Assembly.

E. Hurt, J. Baßler, 2019, Annual review of biochemistry.

An intron in the YRA1 gene is required to control Yra1 protein expression and mRNA export in yeast

E. Hurt, S. Rodríguez-Navarro, K. Sträßer, 2002, EMBO reports.

Utilizing the Dyn2 dimerization-zipper as a tool to probe NPC structure and function.

E. Hurt, Philipp Stelter, D. Flemming, 2014, Methods in cell biology.

Functional reconstitution of mitochondrial Fe/S cluster synthesis on Isu1 reveals the involvement of ferredoxin

U. Linne, E. Hurt, Stefan Amlacher, 2014, Nature Communications.

Analysis of the yeast nucleoporin Nup188 reveals a conserved S-like structure with similarity to karyopherins.

E. Hurt, D. Devos, Stefan Amlacher, 2012, Journal of structural biology.

Mtr 10 p functions as a nuclear import receptor for the mRNA-binding protein Npl 3 p

M. Mann, A. Podtelejnikov, F. Bischoff, 2013 .

The yeast tRNA:pseudouridine synthase Pus1p displays a multisite substrate specificity.

E. Hurt, G. Simos, Y. Motorin, 1998, RNA.

Cse1p functions as the nuclear export receptor for importin alpha in yeast.

M. Künzler, E. Hurt, 1998, FEBS letters.

Linear ubiquitin fusion to Rps31 and its subsequent cleavage are required for the efficient production and functional integrity of 40S ribosomal subunits

E. Hurt, J. de la Cruz, D. Kressler, 2009, Molecular microbiology.

Structural basis for assembly and function of the Nup82 complex in the nuclear pore scaffold

M. Beck, E. Hurt, K. Bui, 2015, The Journal of cell biology.

Nuclear RNA export in yeast

E. Hurt, K. Sträßer, E. Hurt, 1999, FEBS letters.

Nucleocytoplasmic transport: factors and mechanisms

E. Hurt, G. Simos, 1995, FEBS letters.

Structure of the Ubp8-Sgf11-Sgf73-Sus1 SAGA DUB module

Ed Hurt, Alwin Köhler, Erik S. Zimmerman, 2010 .

Analysis of nucleo-cytoplasmic transport in a thermosensitive mutant of nuclear pore protein NSP1.

E. Hurt, U. Nehrbass, E. Fabre, 1993, European journal of cell biology.

Direct and high throughput (HT) interactions on the ribosomal surface by iRIA

E. Hurt, M. Degano, S. Biffo, 2015, Scientific Reports.

Cloning and characterization of the Schizosaccharomyces pombe tRNA:pseudouridine synthase Pus1p.

E. Hurt, G. Simos, Y. Motorin, 2000, Nucleic acids research.

A network of assembly factors is involved in remodeling rRNA elements during preribosome maturation

Sarah A. Clark, D. Tollervey, E. Hurt, 2014, The Journal of cell biology.

NSP1, a yeast protein located at the nuclear periphery, is required for the cell cycle of Saccharomyces cerevisiae

E. Hurt, 1989, Journal of Cell Science.

Formation and nuclear export of tRNA, rRNA and mRNA is regulated by the ubiquitin ligase Rsp5p

E. Petfalski, D. Tollervey, E. Hurt, 2003, EMBO reports.

Mtr10p functions as a nuclear import receptor for the mRNA‐binding protein Npl3p

Matthias Mann, Ed Hurt, M. Mann, 1998, The EMBO journal.

The dual nature of the nucleolus

V. G. Panse, D. Tollervey, E. Hurt, 2022, Genes & development.

Reconstitution of the complete pathway of ITS2 processing at the pre-ribosome

E. Hurt, E. Conti, D. Flemming, 2017, Nature Communications.

Assembly Kinetics of Vimentin Tetramers to Unit-Length Filaments: A Stopped-Flow Study.

W. H. Goldmann, J. Langowski, W. Goldmann, 2018, Biophysical journal.

JCB_200810016 387..396

B. Böttcher, E. Hurt, Philipp Stelter, 2009 .

Unravelling the role of ATP in post-transitional protein translocation

E. Hurt, 1987 .

The cleavable prepiece of an imported mitochondrial protein is sufficient to direct cytosolic dihydrofolate reductase into the mitochondrial matrix

E. Hurt, G. Schatz, B. Pesold-Hurt, 1984, FEBS letters.

Cms1 coordinates stepwise local 90S pre-ribosome assembly with timely snR83 release

E. Hurt, R. Beckmann, D. Kressler, 2022, Cell reports.

Photoaffinity labelling of plastoquinone binding sites in chloroplast cytochrome b 6/f‐complex

E. Hurt, G. Hauska, W. Oettmeier, 1982 .

Extra proton translocation and membrane potential generation--universal properties of cytochrome bc1/b6f complexes reconstituted into liposomes.

W. Lockau, E. Hurt, Y. Shahak, 1983, Archives of biochemistry and biophysics.

A cytochrome f/b6 complex of five polypeptides with plastoquinol-plastocyanin-oxidoreductase activity from spinach chloroplasts.

E. Hurt, G. Hauska, 2005, European journal of biochemistry.

Mutations in the YRB1 gene encoding yeast ran-binding-protein-1 that impair nucleocytoplasmic transport and suppress yeast mating defects.

J. Thorner, M. Künzler, E. Hurt, 2001, Genetics.

Involvement of plastoquinone bound within the isolated cytochrome b6-f complex from chloroplasts in oxidant-induced reduction of cytochrome b6

E. Hurt, G. Hauska, 1982 .

Vectorial redox reactions of physiological quinones. I. Requirement of a minimum length of the isoprenoid side chain.

E. Hurt, G. Hauska, A. Futami, 1979, Biochimica et biophysica acta.

The nuclear envelope of the yeast Saccharomyces cerevisiae.

M. Carmo-Fonseca, E. Hurt, A. Mutvei, 1992, International review of cytology.

Comparative aspects of quinol-cytochrome c/plastocyanin oxidoreductases.

W. Lockau, E. Hurt, G. Hauska, 1983, Biochimica et biophysica acta.

Identification of the polypeptides in the cytochromeb6/f complex from spinach chloroplasts with redox-center-carrying subunits

E. Hurt, G. Hauska, 1982, Journal of bioenergetics and biomembranes.

Electrogenic proton translocation by the chloroplast cytochrome b 6/f complex reconstituted into phospholipid vesicles

E. Hurt, G. Hauska, Y. Shahak, 1982 .

Reduction of cytochromes b6 and f in isolated plastoquinol-plastocyanin oxidoreductase driven by photochemical reaction centers from Rhodopseudomonas sphaeroides.

P. Dutton, E. Hurt, G. Hauska, 1982, The Journal of biological chemistry.

Isolation of the rieske iron‐sulfur protein from the cytochrome b 6/f complex of spinach chloroplasts

E. Hurt, G. Hauska, R. Malkin, 1981, FEBS letters.

Nucleolar KKE/D repeat proteins Nop56p and Nop58p interact with Nop1p and are required for ribosome biogenesis

D. Tollervey, E. Hurt, T. Gautier, 1997, Molecular and cellular biology.

Genes and transcripts for the polypeptides of the cytochrome b6/f complex from spinach thylakoid membranes

E. Hurt, G. Hauska, R. Herrmann, 1983, The EMBO journal.

How proteins find mitochondria and intramitochondrial compartments

E. Hurt, Eduard C. Hurt, Adolphus P. G. M. van Loon, 1986 .

A cytochrome f-b6 complex with plastoquinol-cytochrome c oxidoreductase activity from Anabaena variabilis

W. Lockau, E. Hurt, G. Hauska, 1982 .

Eukaryotic ribosome biogenesis at a glance

E. Hurt, Sébastien Ferreira-Cerca, Emma Thomson, 2013, Journal of Cell Science.

1 – Pool Function Behavior and Mobility of Isoprenoid Quinones

E. Hurt, G. Hauska, 1982 .

Structural requirements of quinone coenzymes for endogenous and dye-mediated coupled electron transport in bacterial photosynthesis

E. Hurt, G. Hauska, N. Gabellini, 1980, Journal of bioenergetics and biomembranes.

Differential extraction and structural specificity of specialized ubiquinone molecules in secondary electron transfer in chromatophores from Rhodopseudomonas sphaeroides, Ga.

A. Crofts, E. Hurt, A. Rutherford, 1982, Archives of biochemistry and biophysics.

Organization and Function of Photosynthetic and Respiratory Cytochrome b/c-FeS Complexes

W. Lockau, E. Hurt, G. Hauska, 1984 .

A cytochrome b/c1 complex with ubiquinol--cytochrome c2 oxidoreductase activity from Rhodopseudomonas sphaeroides GA.

E. Hurt, G. Hauska, J. Bowyer, 1982, European journal of biochemistry.

Pre-ribosomes on the road from the nucleolus to the cytoplasm.

Ed Hurt, E. Hurt, H. Tschochner, 2003, Trends in cell biology.

Maturation and Intranuclear Transport of Pre-Ribosomes Requires Noc Proteins

E. Petfalski, D. Tollervey, E. Hurt, 2001, Cell.

An aminoacylation-dependent nuclear tRNA export pathway in yeast.

E. Hurt, G. Simos, H. Grosshans, 2000, Genes & development.

Nucleus-Specific and Cell Cycle-Regulated Degradation of Mitogen-Activated Protein Kinase Scaffold Protein Ste5 Contributes to the Control of Signaling Competence

J. Thorner, M. Künzler, E. Hurt, 2008, Molecular and Cellular Biology.

The first twelve amino acids (less than half of the pre‐sequence) of an imported mitochondrial protein can direct mouse cytosolic dihydrofolate reductase into the yeast mitochondrial matrix.

E. Hurt, W. Oppliger, G. Schatz, 1985, The EMBO journal.

Nucleolar and nuclear envelope proteins of the yeast Saccharomyces cerevisiae.

A. McDowall, E. Hurt, T. Schimmang, 1988, European journal of cell biology.

A Noc Complex Specifically Involved in the Formation and Nuclear Export of Ribosomal 40 S Subunits*

E. Hurt, J. Baßler, O. Gadal, 2003, The Journal of Biological Chemistry.

Crystal structures of Rea1-MIDAS bound to its ribosome assembly factor ligands resembling integrin–ligand-type complexes

E. Hurt, I. Sinning, M. Thoms, 2019, Nature Communications.

Interdependent action of KH domain proteins Krr1 and Dim2 drive the 40S platform assembly

E. Hurt, R. Beckmann, J. Baßler, 2017, Nature Communications.

Co-translational capturing of nascent ribosomal proteins by their dedicated chaperones

E. Hurt, G. Stier, I. Sinning, 2015, Nature Communications.

New twist to nuclear import

E. Hurt, I. Sinning, D. Kressler, 2013, Communicative & integrative biology.

Synchronizing Nuclear Import of Ribosomal Proteins with Ribosome Assembly

E. Hurt, Stefan Amlacher, I. Sinning, 2012, Science.

The Conserved Bud20 Zinc Finger Protein Is a New Component of the Ribosomal 60S Subunit Export Machinery

E. Hurt, J. Baßler, Bettina Bradatsch, 2012, Molecular and Cellular Biology.

The AAA ATPase Rix7 powers progression of ribosome biogenesis by stripping Nsa1 from pre-60S particles

E. Hurt, D. Kressler, D. Roser, 2008, The Journal of cell biology.

The AAA ATPase Rix 7 powers progression of ribosome biogenesis by stripping Nsa 1 from pre-60 S particles

E. Hurt, D. Kressler, D. Roser, 2008 .

Arx1 functions as an unorthodox nuclear export receptor for the 60S preribosomal subunit.

E. Hurt, R. Peters, J. Baßler, 2007, Molecular cell.

Functional link between ribosome formation and biogenesis of iron–sulfur proteins

V. G. Panse, E. Petfalski, D. Tollervey, 2005, The EMBO journal.

The Yeast Kinase Swe1 is Required for Proper Entry into Cell Cycle After Arrest Due to Ribosome Biogenesis and Protein Synthesis Defects

E. Hurt, J. Baßler, M. L. Carbone, 2004, Cell cycle.

60S pre‐ribosome formation viewed from assembly in the nucleolus until export to the cytoplasm

David Tollervey, Ed Hurt, E. Petfalski, 2002, The EMBO journal.

90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors.

Bernhard Kuster, David Tollervey, Ed Hurt, 2002, Molecular cell.

Splicing factor Sub2p is required for nuclear mRNA export through its interaction with Yra1p

Ed Hurt, E. Hurt, K. Sträßer, 2001, Nature.

Global Transcriptome Characterization and Assembly of the Thermophilic Ascomycete Chaetomium thermophilum

E. Hurt, M. Brunner, N. Kellner, 2021, Genes.

Characterization of Yeast Protein Deg1 as Pseudouridine Synthase (Pus3) Catalyzing the Formation of Ψ38 and Ψ39 in tRNA Anticodon Loop*

E. Hurt, G. Simos, F. Lecointe, 1998, The Journal of Biological Chemistry.

Temperature-sensitive mutations demonstrate roles for yeast fibrillarin in pre-rRNA processing, pre-rRNA methylation, and ribosome assembly

D. Tollervey, E. Hurt, R. Jansen, 1993, Cell.

Pseudouridine Mapping in the Saccharomyces cerevisiae Spliceosomal U Small Nuclear RNAs (snRNAs) Reveals that Pseudouridine Synthase Pus1p Exhibits a Dual Substrate Specificity for U2 snRNA and tRNA

E. Hurt, D. Lafontaine, Y. Motorin, 1999, Molecular and Cellular Biology.

The role of small nucleolar ribonucleoproteins in ribosome synthesis

D. Tollervey, E. Hurt, 2004, Molecular Biology Reports.

NSP1: A yeast nuclear envelope protein localized at the nuclear pores exerts its essential function by its carboxy-terminal domain

H. Horstmann, E. Hurt, U. Nehrbass, 1990, Cell.

Across the nuclear pores with the help of nucleoporins

M. Carmo-Fonseca, E. Hurt, 1991, Chromosoma.

TREX is a conserved complex coupling transcription with messenger RNA export

Kevin Struhl, Seiji Masuda, Ed Hurt, 2002, Nature.

Nucleoporin Nup155 is part of the p53 network in liver cancer

P. Schirmacher, L. Zender, M. Beck, 2019, Nature Communications.

From nucleoporins to nuclear pore complexes.

E. Hurt, V. Doye, E Hurt, 1997, Current opinion in cell biology.

Yeast genetics to dissect the nuclear pore complex and nucleocytoplasmic trafficking.

E. Hurt, E. Fabre, Emmanuelle Fabre, 1997, Annual review of genetics.

Purification of membrane‐bound cytochromes and a photoactive P840 protein complex of the green sulfur bacterium Chlorobium limicola f. thiosulfatophilum

E. Hurt, G. Hauska, 1984 .

The path from nucleolar 90S to cytoplasmic 40S pre‐ribosomes

E. Petfalski, D. Tollervey, E. Hurt, 2003, The EMBO journal.

Identification of a 60S preribosomal particle that is closely linked to nuclear export.

P. Grandi, E. Petfalski, D. Tollervey, 2001, Molecular cell.

RNA Helicase Prp43 and Its Co-factor Pfa1 Promote 20 to 18 S rRNA Processing Catalyzed by the Endonuclease Nob1

D. Tollervey, E. Hurt, C. Schneider, 2009, The Journal of Biological Chemistry.

ATPase-dependent role of the atypical kinase Rio2 on the evolving pre-40S subunit

E. Hurt, Sébastien Ferreira-Cerca, N. LaRonde-LeBlanc, 2012, Nature Structural &Molecular Biology.

Construction of the Central Protuberance and L1 Stalk during 60S Subunit Biogenesis.

E. Hurt, R. Beckmann, O. Berninghausen, 2020, Molecular cell.

Architecture of the Rix1–Rea1 checkpoint machinery during pre-60S-ribosome remodeling

E. Hurt, R. Beckmann, O. Berninghausen, 2015, Nature Structural &Molecular Biology.

Cryo-EM structure of a late pre-40S ribosomal subunit from Saccharomyces cerevisiae

E. Hurt, T. Becker, R. Beckmann, 2017, eLife.

Dominant Rio1 kinase/ATPase catalytic mutant induces trapping of late pre-40S biogenesis factors in 80S-like ribosomes

E. Hurt, Sébastien Ferreira-Cerca, I. Kiburu, 2014, Nucleic acids research.

A pulse-chase epitope labeling to study cellular dynamics of newly synthesized proteins: a novel strategy to characterize NPC biogenesis and ribosome maturation/export.

E. Hurt, Philipp Stelter, 2014, Methods in cell biology.

Monitoring spatiotemporal biogenesis of macromolecular assemblies by pulse-chase epitope labeling.

E. Hurt, K. Thierbach, Ruth Kunze, 2012, Molecular cell.

Hrr25-dependent phosphorylation state regulates organization of the pre-40S subunit

E. Petfalski, D. Tollervey, B. Böttcher, 2006, Nature.

90S pre-ribosome transformation into the primordial 40S subunit

E. Hurt, R. Beckmann, O. Berninghausen, 2020, Science.

Architecture of the 90S Pre-ribosome: A Structural View on the Birth of the Eukaryotic Ribosome

E. Hurt, R. Beckmann, O. Berninghausen, 2016, Cell.

Structure of the Maturing 90S Pre-ribosome in Association with the RNA Exosome.

E. Hurt, R. Beckmann, O. Berninghausen, 2020, Molecular cell.

Mutational Analysis of the Nsa2 N-Terminus Reveals Its Essential Role in Ribosomal 60S Subunit Assembly

E. Hurt, Ruth Kunze, J. Baßler, 2020, International journal of molecular sciences.

Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.

E. Hurt, Ruth Kunze, R. Beckmann, 2019, Molecular cell.

Structure of the nuclear exosome captured on a maturing preribosome

Sebastian Falk, Ed Hurt, Elena Conti, 2018, Science.

Preribosomes escaping from the nucleus are caught during translation by cytoplasmic quality control

E. Hurt, R. Beckmann, C. Barrio-García, 2017, Nature Structural & Molecular Biology.

3.2-Å-resolution structure of the 90S preribosome before A1 pre-rRNA cleavage

Jingdong Cheng, Ed Hurt, E. Hurt, 2017, Nature Structural & Molecular Biology.

Structural insights into the interaction of the nuclear exosome helicase Mtr4 with the preribosomal protein Nop53

E. Hurt, M. Sattler, E. Conti, 2017, RNA.

Structural basis for 5'-ETS recognition by Utp4 at the early stages of ribosome biogenesis

Tamás Fischer, E. Hurt, I. Sinning, 2017, PloS one.

Interaction network of the ribosome assembly machinery from a eukaryotic thermophile

Sonja Bastuck, E. Hurt, G. Stier, 2017, Protein science : a publication of the Protein Society.

Ribosome-stalk biogenesis is coupled with recruitment of nuclear-export factor to the nascent 60S subunit

E. Hurt, R. Beckmann, M. Thoms, 2016, Nature Structural &Molecular Biology.

The K+-dependent GTPase Nug1 is implicated in the association of the helicase Dbp10 to the immature peptidyl transferase centre during ribosome maturation

E. Hurt, M. Thoms, Emma Thomson, 2016, Nucleic acids research.

Concerted removal of the Erb1–Ytm1 complex in ribosome biogenesis relies on an elaborate interface

E. Hurt, I. Sinning, M. Thoms, 2015, Nucleic acids research.

The Exosome Is Recruited to RNA Substrates through Specific Adaptor Proteins

E. Hurt, J. Baßler, S. Griesel, 2015, Cell.

Symportin 1 chaperones 5S RNP assembly during ribosome biogenesis by occupying an essential rRNA-binding site

M. Beck, E. Hurt, A. Ori, 2015, Nature Communications.

60S ribosome biogenesis requires rotation of the 5S ribonucleoprotein particle

Christoph Leidig, Ed Hurt, Irmgard Sinning, 2014, Nature Communications.

Coupled GTPase and remodeling ATPase activities form a checkpoint for ribosome export

D. Tollervey, E. Hurt, S. Granneman, 2013, Nature.

Rrp5p, Noc1p and Noc2p form a protein module which is part of early large ribosomal subunit precursors in S. cerevisiae

E. Hurt, R. Rachel, P. Schultz, 2012, Nucleic acids research.

Structure of the pre-60S ribosomal subunit with nuclear export factor Arx1 bound at the exit tunnel

D. Tollervey, B. Böttcher, E. Hurt, 2012, Nature Structural &Molecular Biology.

The power of AAA-ATPases on the road of pre-60S ribosome maturation — Molecular machines that strip pre-ribosomal particles

E. Hurt, D. Kressler, J. Baßler, 2012, Biochimica et biophysica acta.

Recruitment of the human TREX complex to mRNA during splicing.

Seiji Masuda, Ed Hurt, S. Masuda, 2005, Genes & development.

Formation and Nuclear Export of Preribosomes Are Functionally Linked to the Small‐Ubiquitin‐Related Modifier Pathway

V. G. Panse, E. Petfalski, D. Tollervey, 2006, Traffic.

The NUG1 GTPase Reveals an N-terminal RNA-binding Domain That Is Essential for Association with 60 S Pre-ribosomal Particles*

E. Hurt, J. Baßler, M. Kallas, 2006, Journal of Biological Chemistry.

TOR regulates late steps of ribosome maturation in the nucleoplasm via Nog1 in response to nutrients

E. Hurt, Y. Oda, R. Shioda, 2006, The EMBO journal.

Rea1, a Dynein-related Nuclear AAA-ATPase, Is Involved in Late rRNA Processing and Nuclear Export of 60 S Subunits*

E. Petfalski, D. Tollervey, E. Hurt, 2004, Journal of Biological Chemistry.

A pre-ribosome with a tadpole-like structure functions in ATP-dependent maturation of 60S subunits.

Ueli Aebi, David Tollervey, Ed Hurt, 2004, Molecular cell.

Structural insights into tail-anchored protein binding and membrane insertion by Get3

Karsten Rippe, Ed Hurt, Irmgard Sinning, 2009, Proceedings of the National Academy of Sciences.

Sem1 is a functional component of the nuclear pore complex–associated messenger RNA export machinery

Stefan Kemmler, V. G. Panse, Ed Hurt, 2009, The Journal of cell biology.

The mRNA export machinery requires the novel Sac3p–Thp1p complex to dock at the nucleoplasmic entrance of the nuclear pores

Tamás Fischer, E. Hurt, S. Rodríguez-Navarro, 2002, The EMBO journal.

The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans

E. Hurt, R. Reed, Zhaolan Zhou, 2000, Nature.

A conserved domain within Arc1p delivers tRNA to aminoacyl-tRNA synthetases.

E. Hurt, F. Fasiolo, G. Simos, 1998, Molecular cell.

Cloning and characterization of the Schizosaccharomyces pombe tRNA : pseudouridine synthase Pus 1 p

E. Hurt, G. Simos, Y. Motorin, 2000 .

A Homologous Recombination System to Generate Epitope-Tagged Target Genes in Chaetomium thermophilum: A Genetic Approach to Investigate Native Thermostable Proteins

E. Hurt, N. Kellner, S. Griesel, 2022, International journal of molecular sciences.

Architecture of the fungal nuclear pore inner ring complex

A. Koide, S. Koide, E. Hurt, 2015, Science.

Towards understanding nuclear pore complex architecture and dynamics in the age of integrative structural analysis.

M. Beck, E. Hurt, Martin Beck, 2015, Current opinion in cell biology.

Evidence for an evolutionary relationship between the large adaptor nucleoporin Nup192 and karyopherins

E. Hurt, A. Hoelz, D. H. Lin, 2014, Proceedings of the National Academy of Sciences.

Protein interfaces of the conserved Nup84 complex from Chaetomium thermophilum shown by crosslinking mass spectrometry and electron microscopy.

M. Beck, E. Hurt, K. Thierbach, 2013, Structure.

Structural characterization of a eukaryotic chaperone—the ribosome-associated complex

Stephan Wickles, Jürgen Kopp, Christoph Leidig, 2012, Nature Structural &Molecular Biology.

Precise mapping of subunits in multiprotein complexes by a versatile electron microscopy label

B. Böttcher, E. Hurt, K. Thierbach, 2010, Nature Structural &Molecular Biology.

Molecular basis for the functional interaction of dynein light chain with the nuclear-pore complex

P. Philippsen, B. Böttcher, E. Hurt, 2007, Nature Cell Biology.

Reconstitution of Nup157 and Nup145N into the Nup84 Complex*[boxs]

B. Böttcher, E. Hurt, Ruth Kunze, 2005, Journal of Biological Chemistry.

Consistent mutational paths predict eukaryotic thermostability

P. Bork, M. Arumugam, D. Mende, 2013, BMC Evolutionary Biology.

The structure of Get4 reveals an α‐solenoid fold adapted for multiple interactions in tail‐anchored protein biogenesis

E. Hurt, Stefan Amlacher, I. Sinning, 2010, FEBS letters.

Mutational Uncoupling of the Role of Sus1 in Nuclear Pore Complex Targeting of an mRNA Export Complex and Histone H2B Deubiquitination

E. Hurt, Maren Schneider, A. Köhler, 2009, Journal of Biological Chemistry.

Yeast centrin Cdc31 is linked to the nuclear mRNA export machinery

Tamás Fischer, E. Hurt, E. Schiebel, 2004, Nature Cell Biology.

Structural basis of histone H2A–H2B recognition by the essential chaperone FACT

V. Rybin, E. Hurt, B. Nijmeijer, 2013, Nature.

A Conserved mRNA Export Machinery Coupled to pre-mRNA Splicing

Ed Hurt, E. Hurt, R. Reed, 2002, Cell.

The cleavable pre‐sequence of an imported chloroplast protein directs attached polypeptides into yeast mitochondria

J. Rochaix, E. Hurt, M. Goldschmidt-Clermont, 1986, The EMBO journal.

Nuclear transport and nuclear pores in yeast

E. Hurt, U. Nehrbass, 2004, Antonie van Leeuwenhoek.

The nuclear pore complex in yeast

P. Grandi, E. Hurt, 1995 .

Nuclear transport and nuclear pores in yeast.

E. Hurt, U. Nehrbass, 1992 .

Targeting of a cytosolic protein to the nuclear periphery

E. Hurt, 1990, The Journal of cell biology.

The mRNA export factor Sus1 is involved in Spt/Ada/Gcn5 acetyltransferase-mediated H2B deubiquitinylation through its interaction with Ubp8 and Sgf11.

E. Hurt, A. Köhler, Meritxell Zapater, 2006, Molecular biology of the cell.

The inner nuclear membrane protein Src1 associates with subtelomeric genes and alters their regulated gene expression

J. Pérez-Ortín, Tamás Fischer, E. Hurt, 2008, The Journal of cell biology.

A Proteome-wide Approach Identifies Sumoylated Substrate Proteins in Yeast*

Bernhard Kuster, V. G. Panse, Ed Hurt, 2004, Journal of Biological Chemistry.

Gene regulation by nucleoporins and links to cancer.

E. Hurt, A. Köhler, 2010, Molecular cell.

Structural Basis for Assembly and Activation of the Heterotetrameric SAGA Histone H2B Deubiquitinase Module

E. Hurt, Maren Schneider, A. Köhler, 2010, Cell.

Unconventional tethering of Ulp1 to the transport channel of the nuclear pore complex by karyopherins

V. G. Panse, E. Hurt, B. Küster, 2003, Nature Cell Biology.

NTF2-like domain of Tap plays a critical role in cargo mRNA recognition and export

E. Hurt, Y. Imai, J. Katahira, 2015, Nucleic acids research.

Functional and structural characterization of the mammalian TREX-2 complex that links transcription with nuclear messenger RNA export

E. Hurt, V. Wickramasinghe, R. Laskey, 2012, Nucleic acids research.

Purification of Nuclear Poly(A)-binding Protein Nab2 Reveals Association with the Yeast Transcriptome and a Messenger Ribonucleoprotein Core Structure

A. Budd, B. Böttcher, E. Hurt, 2009, The Journal of Biological Chemistry.

An Endoribonuclease Functionally Linked to Perinuclear mRNP Quality Control Associates with the Nuclear Pore Complexes

D. Tollervey, E. Hurt, C. Schneider, 2009, PLoS biology.

Sus1, a Functional Component of the SAGA Histone Acetylase Complex and the Nuclear Pore-Associated mRNA Export Machinery

Oreto Antúnez, Ed Hurt, J. Pérez-Ortín, 2004, Cell.

Reconstitution of nuclear protein transport with semi-intact yeast cells

P. Silver, E. Hurt, V. Doye, 1993, The Journal of cell biology.

Binding of the Mex67p/Mtr2p Heterodimer to Fxfg, Glfg, and Fg Repeat Nucleoporins Is Essential for Nuclear mRNA Export

Ed Hurt, E. Hurt, J. Baßler, 2000, The Journal of cell biology.

Biogenesis of the Signal Recognition Particle (Srp) Involves Import of Srp Proteins into the Nucleolus, Assembly with the Srp-Rna, and Xpo1p-Mediated Export

E. Hurt, G. Simos, H. Grosshans, 2001, The Journal of cell biology.

The amino‐terminal region of an imported mitochondrial precursor polypeptide can direct cytoplasmic dihydrofolate reductase into the mitochondrial matrix.

E. Hurt, G. Schatz, B. Pesold-Hurt, 1984, The EMBO journal.

Mechanochemical Removal of Ribosome Biogenesis Factors from Nascent 60S Ribosomal Subunits

B. Böttcher, E. Hurt, D. Kressler, 2009, Cell.

Genetic approaches to nuclear pore structure and function.

E. Hurt, V. Doye, 1995, Trends in genetics : TIG.

Targeting of Ran: variation on a common theme?

M. Künzler, E. Hurt, 2001, Journal of cell science.

IDENI'IFICATION AND CHARACI'ERIZATION OF GENES FOR roLYPEPI'IDES OF THE THYLAKOID MEMBRANE

P. Winter, E. Hurt, G. Hauska, 1983 .

Two functionally distinct domains generated by in vivo cleavage of Nup 145 p : a novel biogenesis pathway for nucleoporins Active nucleocytoplasmic transport through NPCs is bi -

B. Dujon, E. Hurt, S. Siniossoglou, 2013 .

Two functionally distinct domains generated by in vivo cleavage of Nup145p: a novel biogenesis pathway for nucleoporins

B. Dujon, E. Hurt, S. Siniossoglou, 1997, The EMBO journal.

Molecular Architecture of the Yeast Nuclear Pore Complex: Localization of Nsp1p Subcomplexes

E. Hurt, U. Aebi, B. Fahrenkrog, 1998, The Journal of cell biology.

Nic96p is required for nuclear pore formation and functionally interacts with a novel nucleoporin, Nup188p

R. Wepf, P. Grandi, U. Zabel, 1996, The Journal of cell biology.

Yeast Ataxin-7 links histone deubiquitination with gene gating and mRNA export

E. Hurt, Maren Schneider, A. Köhler, 2008, Nature Cell Biology.

Membrane curvature induced by Arf1-GTP is essential for vesicle formation

E. Hurt, R. Beck, F. Wieland, 2008, Proceedings of the National Academy of Sciences.

Structural basis for the assembly and nucleic acid binding of the TREX-2 transcription-export complex

E. Hurt, M. Stewart, A. Ellisdon, 2012, Nature Structural &Molecular Biology.

Structural Basis for the Interaction between Yeast Spt-Ada-Gcn5 Acetyltransferase (SAGA) Complex Components Sgf11 and Sus1*

E. Hurt, A. Köhler, M. Stewart, 2009, The Journal of Biological Chemistry.

Emergence of the primordial pre-60S from the 90S pre-ribosome

E. Hurt, R. Beckmann, L. Randau, 2022, Cell reports.

Approaches Towards a Genetic Analysis of the Nuclear Pore Complex in Yeast

E. Hurt, V. Doye, N. Schlaich, 1993 .

Yeast nucleoporin mutants are defective in pre-tRNA splicing

D. Tollervey, E. Hurt, E. Fabre, 1996, Molecular and cellular biology.

A novel nuclear pore protein Nup82p which specifically binds to a fraction of Nsp1p

P. Grandi, E. Hurt, F. Hucho, 1995, The Journal of cell biology.

Nup145p is required for nuclear export of mRNA and binds homopolymeric RNA in vitro via a novel conserved motif

E. Hurt, W. Boelens, I. Mattaj, 1994, Cell.

Deciphering Networks of Protein Interactions at the Nuclear Pore Complex*

Robert J Chalkley, Lan Huang, A. Burlingame, 2002, Molecular & Cellular Proteomics.

Review: transport of tRNA out of the nucleus-direct channeling to the ribosome?

E. Hurt, G. Simos, H. Grosshans, 2000, Journal of structural biology.

A 40 kDa nuclear membrane protein changes its concentration and localization within the nuclear envelope of the yeast Saccharomyces cerevisiae in a cell-cycle dependent manner.

E. Hurt, T. Schimmang, 1989, European journal of cell biology.

Structural Characterization of the Chaetomium thermophilum TREX-2 Complex and its Interaction with the mRNA Nuclear Export Factor Mex67:Mtr2

E. Hurt, E. Valkov, M. Stewart, 2015, Structure.

Structural characterization of the principal mRNA-export factor Mex67–Mtr2 from Chaetomium thermophilum

M. Lamers, E. Hurt, E. Valkov, 2015, Acta crystallographica. Section F, Structural biology communications.

Adaptor Aly and co‐adaptor Thoc5 function in the Tap‐p15‐mediated nuclear export of HSP70 mRNA

Ed Hurt, E. Hurt, Y. Yoneda, 2009, The EMBO journal.

A versatile interaction platform on the Mex67–Mtr2 receptor creates an overlap between mRNA and ribosome export

E. Hurt, M. Lutzmann, Wei Yao, 2008, The EMBO journal.

Modular self‐assembly of a Y‐shaped multiprotein complex from seven nucleoporins

Ueli Aebi, Ed Hurt, Ruth Kunze, 2002, The EMBO journal.

Coordinated Nuclear Import of RNA Polymerase III Subunits

E. Hurt, U. Hardeland, 2006, Traffic.

Analysis of nucleocytoplasmic transport and nuclear envelope structure in yeast disrupted for the gene encoding the nuclear pore protein Nup1p.

E. Hurt, N. Schlaich, 1995, European journal of cell biology.

Coordinated Ribosomal IT S 2 RNA Processing by the Las 1 Complex Integrating Endonuclease , Polynucleotide Kinase , and Exonuclease Activities Graphical

E. Hurt, D. Flemming, Lisa Gasse, 2015 .

Jcb: Report

B. Böttcher, E. Hurt, Philipp Stelter, 2022 .

Sus1, Cdc31, and the Sac3 CID Region Form a Conserved Interaction Platform that Promotes Nuclear Pore Association and mRNA Export

Tamás Fischer, E. Hurt, A. Köhler, 2009, Molecular cell.

NSP1 depletion in yeast affects nuclear pore formation and nuclear accumulation.

E. Hurt, S. Dihlmann, W. Herth, 1992, European journal of cell biology.

A cytosolic protein contains a cryptic mitochondrial targeting signal

E. Hurt, G. Schatz, 1987, Nature.

MHP1, an essential gene in Saccharomyces cerevisiae required for microtubule function

I. Irminger-Finger, E. Hurt, S. Edelstein, 1996, The Journal of cell biology.

NBP35 encodes an essential and evolutionary conserved protein in Saccharomyces cerevisiae with homology to a superfamily of bacterial ATPases.

E. Hurt, E. Fabre, G. Vitale, 1996, Gene.

The first twelve amino acids of a yeast mitochondrial outer membrane protein can direct a nuclear‐coded cytochrome oxidase subunit to the mitochondrial inner membrane.

U. Müller, E. Hurt, G. Schatz, 1985, The EMBO journal.

The nuclear pore complex and its link to mRNP and ribosome biogenesis

E. Hurt, 2011 .

Human nucleoporin p62 and the essential yeast nuclear pore protein NSP1 show sequence homology and a similar domain organization.

M. Carmo-Fonseca, E. Hurt, H. Kern, 1991, European journal of cell biology.

Adjunct duties for karyopherins: regulating septin sumoylation.

V. G. Panse, E. Hurt, 2007, Developmental cell.

Cytochrome b6 from isolated cytochrome b6f complexes: Evidence for two spectral forms with different midpoint potentials

E. Hurt, G. Hauska, 1983 .

A short linear motif in scaffold Nup145C connects Y-complex with pre-assembled outer ring Nup82 complex

M. Beck, E. Hurt, J. Kosiński, 2017, Nature Communications.

Structural basis for assembly and function of the Nup82 complex in the nuclear pore scaffold

Martin Beck, Alexander von Appen, Ed Hurt, 2015, The Journal of cell biology.

The intracellular location of two aminoacyl‐tRNA synthetases depends on complex formation with Arc1p

E. Hurt, G. Simos, H. Grosshans, 2001, The EMBO journal.

Arc1p Organizes the Yeast Aminoacyl-tRNA Synthetase Complex and Stabilizes Its Interaction with the Cognate tRNAs*

E. Hurt, F. Fasiolo, G. Simos, 2001, The Journal of Biological Chemistry.

Coordinated Ribosomal L4 Protein Assembly into the Pre-Ribosome Is Regulated by Its Eukaryote-Specific Extension.

E. Hurt, A. Hoelz, F. Huber, 2015, Molecular cell.

Suppressor mutations in Rpf2–Rrs1 or Rpl5 bypass the Cgr1 function for pre-ribosomal 5S RNP-rotation

L. Falquet, E. Hurt, R. Beckmann, 2018, Nature Communications.

Interdependent action of KH domain proteins Krr1 and Dim2 drive the 40S platform assembly

E. Hurt, R. Beckmann, J. Baßler, 2017, Nature Communications.

Yeast nuclear pore complex assembly defects determined by nuclear envelope reconstruction.

T. Giddings, E. Hurt, M. Winey, 2000, Journal of structural biology.

Purification of NSP1 reveals complex formation with ‘GLFG’ nucleoporins and a novel nuclear pore protein NIC96.

P. Grandi, E. Hurt, V. Doye, 1993, The EMBO journal.

The small nucleolar RNP protein NOP1 (fibrillarin) is required for pre‐rRNA processing in yeast.

D. Tollervey, M. Carmo-Fonseca, E. Hurt, 1991, The EMBO journal.

Coordinated Ribosomal L 4 Protein Assembly into the Pre-Ribosome IsRegulated by Its Eukaryote-Specific Extension Graphical Abstract Highlights

E. Hurt, A. Hoelz, F. Huber, 2015 .

Suppressor mutations in Rpf2–Rrs1 or Rpl5 bypass the Cgr1 function for pre-ribosomal 5S RNP-rotation

L. Falquet, E. Hurt, R. Beckmann, 2018, Nature Communications.

The small nucleolar rnp protein nop1 fibrillarin is required for precursor ribosomal rna processing in yeast

D. Tollervey, E. Hurt, H. Lehtonen, 1991 .

A generic strategy to analyze the spatial organization of multi-protein complexes by cross-linking and mass spectrometry.

M. Mann, J. Rappsilber, E. Hurt, 2000, Analytical chemistry.

Probing the nucleoporin FG repeat network defines structural and functional features of the nuclear pore complex

E. Hurt, Jessica Fischer, Ruth Kunze, 2011, The Journal of cell biology.

Functional interaction of Nic96p with a core nucleoporin complex consisting of Nsp1p, Nup49p and a novel protein Nup57p.

P. Grandi, E. Hurt, N. Schlaich, 1995, The EMBO journal.

A new subclass of nucleoporins that functionally interact with nuclear pore protein NSP1.

P. Grandi, E. Hurt, V. Doye, 1992, EMBO Journal.

A novel nucleoskeletal‐like protein located at the nuclear periphery is required for the life cycle of Saccharomyces cerevisiae.

E. Hurt, E. Hurt, 1988, The EMBO journal.