D. Sheppard

D. Sheppard, G. Roodman, N. Kurihara, 2006, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

The Integrin α9β1 Mediates Adhesion to Activated Endothelial Cells and Transendothelial Neutrophil Migration through Interaction with Vascular Cell Adhesion Molecule-1

D. Sheppard, T. Yednock, John J. S. Chen, 1999, The Journal of cell biology.

Polymerase chain reaction cloning with degenerate primers: homology-based identification of adhesion molecules.

D. Sheppard, J. Breuss, D. Erle, 1994, Methods in enzymology.

The integrin alphavbeta6 is critical for keratinocyte migration on both its known ligand, fibronectin, and on vitronectin.

D. Sheppard, X. Huang, Xiaozhu Huang, 1998, Journal of cell science.

The integrin alpha 9 beta 1 mediates cell attachment to a non-RGD site in the third fibronectin type III repeat of tenascin.

D. Sheppard, Y. Yokosaki, R. Pytela, 1994, The Journal of biological chemistry.

Fibronectin and its alpha 5 beta 1-integrin receptor are involved in the wound-repair process of airway epithelium.

J. Zahm, H. Kaplan, D. Sheppard, 1996, The American journal of physiology.

An Epithelial Integrin Regulates the Amplitude of Protective Lung Interferon Responses against Multiple Respiratory Pathogens

D. Sheppard, Shalini Sharma, P. Thomas, 2016, PLoS pathogens.

Chapter 21 – Adhesion Molecules in Asthma and Airway Diseases

D. Sheppard, 2009 .

Induction of an epithelial integrin alphavbeta6 in human cytomegalovirus-infected endothelial cells leads to activation of transforming growth factor-beta1 and increased collagen production.

D. Sheppard, H. Kawakatsu, E. Maidji, 2008, The American journal of pathology.

Induction of an Epithelial Integrin (cid:1) v (cid:2) 6 in Human Cytomegalovirus-Infected Endothelial Cells Leads to Activation of Transforming Growth Factor- (cid:2) 1 and Increased Collagen Production

D. Sheppard, H. Kawakatsu, E. Maidji, 2008 .

This information is current as Airway Smooth Muscle Cells in Asthma Activation by β 5-Mediated TGF-β v α Integrin

Habgood, C. Brightling, D. Sheppard, 2011 .

Differential effects of the integrins alpha9beta1, alphavbeta3, and alphavbeta6 on cell proliferative responses to tenascin. Roles of the beta subunit extracellular and cytoplasmic domains.

J. Chen, D. Sheppard, Y. Yokosaki, 1996, The Journal of biological chemistry.

Integrin αvβ5 Regulates Lung Vascular Permeability and Pulmonary Endothelial Barrier Function

D. Sheppard, J. Pittet, M. Matthay, 2007 .

Genomics and proteomics of lung disease: conference summary.

John Quackenbush, Naftali Kaminski, Scott T Weiss, 2007, American journal of physiology. Lung cellular and molecular physiology.

Toluene diisocyanate increases airway responsiveness to substance P and decreases airway neutral endopeptidase.

D. Sheppard, J. Nadel, D. Dusser, 1988, The Journal of clinical investigation.

Dual antagonists of α5β1/ αvβ1 integrin for airway hyperresponsiveness.

W. DeGrado, D. Sheppard, M. Adler, 2020, Bioorganic & medicinal chemistry letters.

Expression That Promotes Airway Fibrosis Airway Eosinophilia and Epithelial FIZZ1 Induces STAT6-Dependent Acute Alternaria

D. Sheppard, M. Croft, D. Broide, 2017 .

Epithelial Thickness Expression That Promotes Airway Fibrosis Airway Eosinophilia and Epithelial FIZZ 1 Induces STAT 6-Dependent Acute Alternaria

D. Sheppard, M. Croft, D. Broide, 2012 .

Interleukin-1 β Causes Acute Lung Injury via α v β 5 and α v β 6 Integrin – Dependent Mechanisms

P. Weinreb, S. Violette, D. Sheppard, 2009 .

Characterization of integrin β6 and thrombospondin‐1 double‐null mice

A. Ludlow, P. Weinreb, R. Bronson, 2005, Journal of cellular and molecular medicine.

Mfge8 is critical for mammary gland remodeling during involution.

Z. Werb, D. Sheppard, I. Ueki, 2005, Molecular biology of the cell.

Transforming growth factor-beta-dependent and -independent pathways of induction of tubulointerstitial fibrosis in beta6(-/-) mice.

D. Sheppard, Li-jun Ma, A. Fogo, 2003, The American journal of pathology.

The α9β1 integrin enhances cell migration by polyamine-mediated modulation of an inward-rectifier potassium channel

D. Sheppard, A. Pegg, G. Dehart, 2008, Proceedings of the National Academy of Sciences.

COMPOSITIONS ET METHODES DE TRAITEMENT ET DE PREVENTION D'UNE MALADIE ASSOCIEE A L'INTEGRINE αVβ5

D. Sheppard, A. Atakilit, 2005 .

Sequence and tissue distribution of the human integrin α8 subunit: a β1-associated α subunit expressed in smooth muscle cells

D. Sheppard, J. Breuss, L. Schnapp, 1995 .

Enteric expression of the integrin alpha(v)beta(6) is essential for nematode-induced mucosal mast cell hyperplasia and expression of the granule chymase, mouse mast cell protease-1.

D. Sheppard, H. Miller, P. Knight, 2002, The American journal of pathology.

Enteric Expression of the Integrin αvβ6 Is Essential for Nematode-Induced Mucosal Mast Cell Hyperplasia and Expression of the Granule Chymase, Mouse Mast Cell Protease-1

D. Sheppard, H. Miller, P. Knight, 2002 .

Retraction. Induction of a homeostatic circuit in lung tissue by microbial compounds.

D. Sheppard, E. Raz, Tomoko Hayashi, 2006, Immunity.

Epithelial and Mesenchymal Cell Biology v 6 Integrin Regulates Renal Fibrosis and Inflammation in Alport Mouse

K. Simon, P. Weinreb, S. Violette, 2006 .

Effects of beta subunit cytoplasmic domain deletions on the recruitment of the integrin alpha v beta 6 to focal contacts.

D. Sheppard, R. Cone, A. Chen, 1994, Cell adhesion and communication.

Inflammatory cues enhance TGFβ activation by distinct subsets of human intestinal dendritic cells via integrin αvβ8

D. Sheppard, F. Powrie, S. Levison, 2016, Mucosal Immunology.

Identification of the Ligand Binding Site for the Integrin α9β1 in the Third Fibronectin Type III Repeat of Tenascin-C*

D. Sheppard, M. Obara, N. Matsuura, 1998, The Journal of Biological Chemistry.

Integrin αvβ6 Is an RGD-Dependent Receptor for Coxsackievirus A9

T. Hyypiä, D. Sheppard, T. Kajander, 2004, Journal of Virology.

Integrin αvβ1 Is a Receptor for Foot-and-Mouth Disease Virus

D. Sheppard, A. Mould, T. Jackson, 2002, Journal of Virology.

for Foot-and-Mouth Disease Virus 6 Is a Receptor β v α The Epithelial Integrin

D. Sheppard, T. Jackson, A. King, 2000 .

Integrin-α9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis

D. Sheppard, R. Adams, A. Muro, 2009, Developmental cell.

Mapping of the cryptic integrin-binding site in osteopontin suggests a new mechanism by which thrombin can regulate inflammation and tissue repair.

D. Sheppard, Y. Yokasaki, 2000, Trends in cardiovascular medicine.

Integrin α2β1 regulates collagen I tethering to modulate hyperresponsiveness in reactive airway disease models.

W. DeGrado, D. Sheppard, Xiaozhu Huang, 2021, The Journal of clinical investigation.

Airway epithelial integrins: why so many?

D. Sheppard, 1998, American journal of respiratory cell and molecular biology.

Interleukin-13 induces dramatically different transcriptional programs in three human airway cell types.

N. Kaminski, D. Sheppard, D. Erle, 2001, American journal of respiratory cell and molecular biology.

Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury.

R. Chambers, G. Laurent, D. Sheppard, 2006, The Journal of clinical investigation.

Vitronectin enhances internalization of crocidolite asbestos by rabbit pleural mesothelial cells via the integrin alpha v beta 5.

D. Sheppard, D. Sanan, V. Broaddus, 1995, The Journal of clinical investigation.

Short form of α9 promotes α9β1 integrin-dependent cell adhesion by modulating the function of the full-length α9 subunit.

D. Sheppard, S. Kon, A. Atakilit, 2011, Experimental cell research.

beta6 Integrin subunit deficiency alleviates lung injury in a mouse model of bronchopulmonary dysplasia.

D. Sheppard, U. Lappalainen, K. Bry, 2010, American journal of respiratory cell and molecular biology.

b 6 Integrin Subunit Deﬁciency Alleviates Lung Injury in a Mouse Model of Bronchopulmonary Dysplasia

D. Sheppard, U. Lappalainen, K. Bry, 2010 .

Transforming Growth Factor A Central Modulator of Pulmonary and Airway Inflammation and Fibrosis

D. Sheppard, Dean Sheppard, 2006 .

Expression of the human integrin beta6 subunit in alveolar type II cells and bronchiolar epithelial cells reverses lung inflammation in beta6 knockout mice.

D. Sheppard, X. Huang, R. Pytela, 1998, American journal of respiratory cell and molecular biology.

Requirements for Allergen-Induced Airway Hyperreactivity in T and B Cell-Deficient Mice

R. Locksley, V. Kurup, D. Sheppard, 1998, Molecular medicine.

Role of multiple β1 integrins in cell adhesion to the disintegrin domains of ADAMs 2 and 3

M. Stepp, D. Sheppard, S. Coonrod, 2003 .

Role of multiple beta1 integrins in cell adhesion to the disintegrin domains of ADAMs 2 and 3.

M. Stepp, D. Sheppard, S. Coonrod, 2003, Experimental cell research.

Structural requirements of MLD-containing disintegrins for functional interaction with alpha 4 beta 1 and alpha 9 beta1 integrins.

J. Calvete, D. Sheppard, R. Theakston, 2004, Biochemistry.

Identification and molecular characterization of multiple phenotypes in integrin knockout mice.

D. Sheppard, Chun Chen, 2007, Methods in enzymology.

Integrin alpha v beta 8. Interaction with vitronectin and functional divergence of the beta 8 cytoplasmic domain.

D. Sheppard, S. Nishimura, R. Pytela, 1994, The Journal of biological chemistry.

Roles of αv integrins in vascular biology and pulmonary pathology

D. Sheppard, 2004 .

Macrophage Cx43 Is Necessary for Fibroblast Cytosolic Calcium and Lung Fibrosis After Injury

D. Sheppard, S. Nishimura, M. Bhattacharya, 2022, Frontiers in Immunology.

Lack of Flvcr2 impairs brain angiogenesis without affecting the blood-brain barrier.

C. Betsholtz, D. Sheppard, Gabriel L. McKinsey, 2020, The Journal of clinical investigation.

Differential Enzymatic Activity of Common Haplotypic Versions of the Human Acidic Mammalian Chitinase Protein*

E. Burchard, S. Choudhry, W. Rodriguez-Cintron, 2009, The Journal of Biological Chemistry.

Integrin b 6 Mediates Phospholipid and Collectin Homeostasis by Activation of Latent TGF- b 1

David G. Morris, D. Sheppard, D. Erle, 2007 .

The Integrin avb6 Binds and Activates Latent TGFb1: A Mechanism for Regulating Pulmonary Inflammation and Fibrosis

N. Kaminski, D. Sheppard, D. Rifkin, 1999 .

Roles of alphav integrins in vascular biology and pulmonary pathology.

D. Sheppard, 2004, Current opinion in cell biology.

Expression of the β6 Integrin Subunit Is Associated with Sites of Neutrophil Influx in Lung Epithelium

D. Sheppard, D. Hyde, L. Miller, 2001, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Epidermal integrin expression is upregulated rapidly in human fetal wound repair.

K. Sylvester, M. Herlyn, D. Sheppard, 1998, Journal of pediatric surgery.

Differential regulation of airway epithelial integrins by growth factors.

D. Sheppard, Y. Yokosaki, R. Ferrando, 1996, American journal of respiratory cell and molecular biology.

Transforming Growth Factor-β1 Decreases Expression of the Epithelial Sodium Channel αENaC and Alveolar Epithelial Vectorial Sodium and Fluid Transport via an ERK1/2-dependent Mechanism*

D. Sheppard, J. Pittet, H. Kawakatsu, 2003, Journal of Biological Chemistry.

Transforming growth factor-beta1 decreases expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2-dependent mechanism.

D. Sheppard, J. Pittet, H. Kawakatsu, 2003, The Journal of biological chemistry.

Integrin αvβ6 critically regulates hepatic progenitor cell function and promotes ductular reaction, fibrosis, and tumorigenesis

D. Schuppan, P. Weinreb, S. Violette, 2016, Hepatology.

Stuck in a Moment: Does Abnormal Persistence of Epithelial Progenitors Drive Pulmonary Fibrosis?

D. Sheppard, V. Auyeung, 2020, American journal of respiratory and critical care medicine.

6 Integrin Subunit Is Associated with Sites of Neutrophil Influx in Lung Epithelium β Expression of the

D. Sheppard, D. Hyde, L. Miller, 2013 .

Adaptive Immune Regulation of Mammary Postnatal Organogenesis.

Z. Werb, V. Plaks, D. Sheppard, 2015, Developmental cell.

Adaptive Immune Regulation of Mammary Postnatal Organogenesis Graphical

Z. Werb, V. Plaks, D. Sheppard, 2015 .

Integrin alphavbeta5 regulates lung vascular permeability and pulmonary endothelial barrier function.

D. Sheppard, J. Pittet, M. Matthay, 2007, American journal of respiratory cell and molecular biology.

Integrin alpha9beta1 directly binds to vascular endothelial growth factor (VEGF)-A and contributes to VEGF-A-induced angiogenesis.

D. Sheppard, N. Boudreau, A. Atakilit, 2007, The Journal of biological chemistry.

The lymphangiogenic vascular endothelial growth factors VEGF-C and -D are ligands for the integrin alpha9beta1.

D. Sheppard, A. Atakilit, N. Vlahakis, 2005, The Journal of biological chemistry.

Inhibiting Integrin αvβ5 Reduces Ischemia–Reperfusion Injury in an Orthotopic Lung Transplant Model in Mice

D. Sheppard, F. Liu, B. Mallavia, 2016, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Transforming growth factor beta differentially regulates expression of integrin subunits in guinea pig airway epithelial cells.

D. Cohen, D. Sheppard, A. Wang, 1992, The Journal of biological chemistry.

Endothelial integrins and angiogenesis: not so simple anymore.

D. Sheppard, 2002, The Journal of clinical investigation.

Expression of the alphavbeta6 integrin promotes migration and invasion in squamous carcinoma cells.

D. Sheppard, P. Speight, G. Thomas, 2001, The Journal of investigative dermatology.

Characterization of the integrin alpha v beta 6 as a fibronectin-binding protein.

D. Sheppard, R. Pytela, M. Busk, 1992, The Journal of biological chemistry.

Absence of integrin αvβ3 enhances vascular leak in mice by inhibiting endothelial cortical actin formation.

D. Sheppard, M. Bhattacharya, A. Atakilit, 2012, American journal of respiratory and critical care medicine.

The alpha v beta 6 integrin promotes proliferation of colon carcinoma cells through a unique region of the beta 6 cytoplasmic domain

D. Sheppard, M. Agrez, R. Cone, 1994, The Journal of cell biology.

The cytoplasmic domain of the integrin alpha9 subunit requires the adaptor protein paxillin to inhibit cell spreading but promotes cell migration in a paxillin-independent manner.

D. Sheppard, S. M. Thomas, Y. Yokosaki, 2001, Molecular biology of the cell.

Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions.

E. Engvall, D. Sheppard, Y. Takada, 2002, The Journal of biological chemistry.

Role of the integrin alpha v beta 6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor.

D. Sheppard, E. Wayner, M. Agrez, 1994, The Journal of biological chemistry.

Distinct Structural Requirements for Interaction of the Integrins α5β1, αvβ5, and αvβ6 with the Central Cell Binding Domain in Fibronectin

K. Sekiguchi, D. Sheppard, John J. S. Chen, 1996 .

Modulation of acute lung injury by integrins.

D. Sheppard, 2012, Proceedings of the American Thoracic Society.

Identification and characterization of novel airway epithelial integrins.

D. Sheppard, 1993, The American review of respiratory disease.

Uses of Expression Microarrays in Studies of Pulmonary Fibrosis, Asthma, Acute Lung Injury, and Emphysema: Roger S. Mitchell Lecture

D. Sheppard, 2002 .

Roger S. Mitchell lecture. Uses of expression microarrays in studies of pulmonary fibrosis, asthma, acute lung injury, and emphysema.

D. Sheppard, 2002, Chest.

THE ALPHA-V-BETA-6 IS THE MAJOR INTEGRIN OF THE ALPHA-UPSILON-FAMILY IN WOUND KERATINOCYTES

H. Larjava, T. Salo, K. Haapasalmi, 1995 .

Interleukin-1β Decreases Expression of the Epithelial Sodium Channel α-Subunit in Alveolar Epithelial Cells via a p38 MAPK-dependent Signaling Pathway*

D. Sheppard, J. Pittet, H. Kawakatsu, 2005, Journal of Biological Chemistry.

Integrin alpha v beta 6 is an RGD-dependent receptor for coxsackievirus A9.

T. Hyypiä, D. Sheppard, T. Kajander, 2004, Journal of virology.

IgA production requires B cell interaction with subepithelial dendritic cells in Peyer’s patches

D. Sheppard, J. Cyster, T. Arnon, 2016, Science.

The Integrin α9β1 Contributes to Granulopoiesis by Enhancing Granulocyte Colony-Stimulating Factor Receptor Signaling

S. Corey, D. Sheppard, Quan-sheng Zhu, 2006 .

Sequence and tissue distribution of the integrin alpha 9 subunit, a novel partner of beta 1 that is widely distributed in epithelia and muscle [published erratum appears in J Cell Biol 1994 Feb;124(3):395]

D. Sheppard, C. Rüegg, R. Pytela, 1993, The Journal of cell biology.

Tissue Transglutaminase, Coagulation Factor XIII, and the Pro-polypeptide of von Willebrand Factor Are All Ligands for the Integrins α9β1 and α4β1 *

J. Takagi, D. Sheppard, Yuji Saito, 2000, The Journal of Biological Chemistry.

Tissue transglutaminase, coagulation factor XIII, and the pro-polypeptide of von Willebrand factor are all ligands for the integrins alpha 9beta 1 and alpha 4beta 1.

J. Takagi, D. Sheppard, Y. Yokosaki, 2000, The Journal of biological chemistry.

Essential role for MFG-E8 as ligand for αvβ5 integrin in diurnal retinal phagocytosis

D. Sheppard, E. Nandrot, K. Atabai, 2007, Proceedings of the National Academy of Sciences.

The response of guinea pig airway epithelial cells and alveolar macrophages to environmental stress.

D. Cohen, D. Sheppard, W. Welch, 1991, American journal of respiratory cell and molecular biology.

Killed by leukocytes that don't know when to leave

D. Sheppard, 2002, Nature Immunology.

IL-17A Recruits Rab35 to IL-17R to Mediate PKCα-Dependent Stress Fiber Formation and Airway Smooth Muscle Contractility

D. Sheppard, J. Zepp, A. Echard, 2019, The Journal of Immunology.

Alphav beta6 integrin regulates renal fibrosis and inflammation in Alport mouse.

K. Simon, P. Weinreb, S. Violette, 2007, The American journal of pathology.

TGF-b is a critical mediator of acute lung injury

N. Kaminski, D. Sheppard, T. Geiser, 2018 .

The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin.

D. Sheppard, I. Klimanskaya, L. Schnapp, 1995, The Journal of biological chemistry.

Integrin-mediated activation of transforming growth factor-beta(1) in pulmonary fibrosis.

D. Sheppard, 2001, Chest.

Lysophosphatidic Acid Induces (cid:1) v (cid:2) 6 Integrin-Mediated TGF- (cid:2) Activation via the LPA2 Receptor and the Small G Protein G (cid:1) q

P. Weinreb, S. Violette, D. Sheppard, 2009 .

Differential Effects of the Integrins α9β1, αvβ3, and αvβ6 on Cell Proliferative Responses to Tenascin

D. Sheppard, Y. Yokosaki, John J. S. Chen, 1996, The Journal of Biological Chemistry.

Thrombin-cleaved osteopontin regulates hemopoietic stem and progenitor cell functions through interactions with (cid:1) 9 (cid:2) 1 and (cid:1) 4 (cid:2) 1 integrins

Cheang Ly Be, D. Sheppard, B. Williams, 2009 .

Loss of Synchronized Retinal Phagocytosis and Age-related Blindness in Mice Lacking (cid:1) v (cid:2) 5 Integrin

S. Brodie, D. Sheppard, E. Nandrot, 2004 .

The αvβ1 integrin plays a critical in vivo role in tissue fibrosis

W. DeGrado, D. Sheppard, Chun Chen, 2015, Science Translational Medicine.

αVβ8 integrin targeting to prevent posterior capsular opacification

D. Sheppard, M. Duncan, Yan Wang, 2021, JCI insight.

Regulated expression of the integrin alpha9beta1 in the epithelium of the developing human gut and in intestinal cell lines: relation with cell proliferation.

D. Sheppard, J. Beaulieu, N. Desloges, 1998 .

Regulated expression of the integrin α9β1 in the epithelium of the developing human gut and in intestinal cell lines: Relation with cell proliferation

D. Sheppard, J. Beaulieu, N. Desloges, 1998, Journal of cellular biochemistry.

Expression of the α9β1 integrin in human colonic epithelial cells: Resurgence of the fetal phenotype in a subset of colon cancers and adenocarcinoma cell lines

D. Sheppard, J. Beaulieu, N. Desloges, 1998 .

Population stratification confounds genetic association studies among Latinos

N. Risch, P. Kwok, Hua Tang, 2005, Human Genetics.

Edinburgh Research Explorer Enteric Expression of the Integrin v6 Is Essential for Nematode-Induced Mucosal Mast Cell Hyperplasia and Expression of the Granule Chymase, Mouse Mast Cell Protease-1

D. Sheppard, H. Miller, Xiaozhu Huang, 2002 .

Integrin α9 on lymphatic endothelial cells regulates lymphocyte egress

M. Ishii, A. Takaoka, D. Sheppard, 2014, Proceedings of the National Academy of Sciences.

Phosphorylation of Trask by Src Kinases Inhibits Integrin Clustering and Functions in Exclusion with Focal Adhesion Signaling

N. Sergina, M. Moasser, D. Sheppard, 2010, Molecular and Cellular Biology.

Sequence and tissue distribution of the human integrin alpha 8 subunit: a beta 1-associated alpha subunit expressed in smooth muscle cells.

D. Sheppard, J. Breuss, L. Schnapp, 1995, Journal of cell science.

A Point Mutation in the Integrin {36 Subunit Abolishes Both exv{36 Binding to Fibronectin and Receptor Localization to Focal Contacts

D. Sheppard, M. Agrez, Xiaozhu Huang, 1995 .

The Integrin a 9 b 1 Mediates Adhesion to Activated Endothelial Cells and Transendothelial Neutrophil Migration through Interaction with Vascular Cell Adhesion Molecule-1

D. Sheppard, T. Yednock, John J. S. Chen, 1999 .

Interleukin-1 Causes Acute Lung Injury via v 5 and v 6 Integrin–Dependent Mechanisms

P. Weinreb, S. Violette, D. Sheppard, 2008 .

Interleukin-1 (cid:1) Causes Acute Lung Injury via (cid:2) v (cid:1) 5 and (cid:2) v (cid:1) 6 Integrin–Dependent Mechanisms Molecular Medicine

P. Weinreb, S. Violette, D. Sheppard, 2008 .

Dominant negative mutants: tools for the study of protein function in vitro and in vivo.

D. Sheppard, 1994, American journal of respiratory cell and molecular biology.

Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma

D. Sheppard, D. Erle, G. Dolganov, 2002, Nature Medicine.

Aspen Lung Conference 2010: systems biology of lung diseases--progress in the omics era.

D. Sheppard, 2011, Proceedings of the American Thoracic Society.

Disruption of integrin function and induction of tyrosine phosphorylation by the autonomously expressed beta 1 integrin cytoplasmic domain.

D. Sheppard, M. Lukashev, R. Pytela, 1994, The Journal of biological chemistry.

Integrin-mediated regulation of TGFβ in fibrosis.

D. Sheppard, N. Henderson, 2013, Biochimica et biophysica acta.

Differential modulation of integrin receptors and extracellular matrix laminin by transforming growth factor-beta 1 in rat alveolar epithelial cells.

D. Sheppard, J. Lwebuga-Mukasa, N. Kumar, 1995, Experimental cell research.

Integrin-mediated transforming growth factor-β activation

D. Sheppard, G. Jenkins, 2010 .

Induced hepatic stellate cell integrin, α8β1, enhances cellular contractility and TGFβ activity in liver fibrosis

K. Chayama, D. Sheppard, K. Sentani, 2021, The Journal of pathology.

Vitronectin Enhances Internalization of Crocidolite Asbestos by Rabbit Pleural Mesothelial Cells via the Integrin avfi5

D. Sheppard, Alice., David, 2013 .

Innate antiviral host defense attenuates TGF-β function through IRF3-mediated suppression of Smad signaling.

R. Derynck, J. Bluestone, D. Sheppard, 2014, Molecular cell.

Interleukin-1beta decreases expression of the epithelial sodium channel alpha-subunit in alveolar epithelial cells via a p38 MAPK-dependent signaling pathway.

D. Sheppard, J. Pittet, H. Kawakatsu, 2005, The Journal of biological chemistry.

Novel integrin α and β subunit cDNAs identified in airway epithelial cells and lung leukocytes using the polymerase chain reaction

D. Sheppard, C. Rüegg, J. Breuss, 1991 .

Identification of novel airway epithelial integrins using the homology-based polymerase chain reaction.

D. Sheppard, D. Erle, R. Pytela, 1992, Chest.

Tracing the origin of pathologic pulmonary fibroblasts

D. Sheppard, T. Tsukui, 2022, bioRxiv.

Integrin (cid:2) v (cid:3) 1 Is a Receptor for Foot-and-Mouth Disease Virus

D. Sheppard, A. Mould, T. Jackson, 2001 .

Increased Expression of Tenascin-C-binding Epithelial Integrins in Human Bullous Keratopathy Corneas

A. Ljubimov, M. Kenney, D. Sheppard, 2001, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

A novel peptide, PLAEIDGIELTY, for the targeting of α9β1‐integrins

D. Sheppard, R. Harbottle, C. Coutelle, 1998, FEBS letters.

Pulmonary Th17 Antifungal Immunity Is Regulated by the Gut Microbiome

W. Ouyang, D. Sheppard, K. Bibby, 2016, The Journal of Immunology.

Fatal Bilateral Chylothorax in Mice Lacking the Integrin α9β1

Robert V Farese, D. Sheppard, X. Huang, 2000, Molecular and Cellular Biology.

Essential role for MFG-E8 as ligand for alphavbeta5 integrin in diurnal retinal phagocytosis.

D. Sheppard, E. Nandrot, K. Atabai, 2007, Proceedings of the National Academy of Sciences of the United States of America.

TGF-β activation and function in immunity.

Dean Sheppard, D. Sheppard, M. Travis, 2014, Annual review of immunology.

Regulatory T cells promote cancer immune-escape through integrin αvβ8-mediated TGF-β activation

D. Sheppard, S. Dalle, M. Travis, 2021, Nature Communications.

The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis.

N. Kaminski, D. Sheppard, D. Rifkin, 1999, Cell.

Loss of integrin αvβ8 on dendritic cells causes autoimmunity and colitis in mice

J. Bluestone, D. Sheppard, E. Masteller, 2007 .

Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice.

J. Bluestone, D. Sheppard, E. Masteller, 2007, Nature.

An integrated cell atlas of the human lung in health and disease

Malte D. Luecken, M. Krasnow, O. Rozenblatt-Rosen, 2022, bioRxiv.

Lysophosphatidic acid induces alphavbeta6 integrin-mediated TGF-beta activation via the LPA2 receptor and the small G protein G alpha(q).

P. Weinreb, S. Violette, D. Sheppard, 2009, The American journal of pathology.

Impaired αVβ8 and TGFβ signaling lead to microglial dysmaturation and neuromotor dysfunction

E. Huang, D. Sheppard, L. Reichardt, 2019, The Journal of experimental medicine.

Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin

Robert V Farese, S. Young, D. Sheppard, 1996, The Journal of cell biology.

Plasmin-Sensitive Dibasic Sequences in the Third Fibronectin-like Domain of L1–Cell Adhesion Molecule (CAM) Facilitate Homomultimerization and Concomitant Integrin Recruitment

D. Sheppard, A. Montgomery, S. Silletti, 2000, The Journal of cell biology.

TGF-β1 Signaling and Tissue Fibrosis.

D. Sheppard, H. Chapman, Kevin K. Kim, 2018, Cold Spring Harbor perspectives in biology.

Functions of pulmonary epithelial integrins: from development to disease.

D. Sheppard, 2003, Physiological reviews.

A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1

N. Kaminski, D. Sheppard, D. Rifkin, 1999, Cell.

Keratinocytes in human wounds express alpha v beta 6 integrin.

H. Larjava, T. Salo, K. Haapasalmi, 1996, The Journal of investigative dermatology.

Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis

N. Kaminski, D. Sheppard, P. Wolters, 2020, Nature Communications.

α-PD-1 therapy elevates Treg/Th balance and increases tumor cell pSmad3 that are both targeted by α-TGFβ antibody to promote durable rejection and immunity in squamous cell carcinomas

A. Balmain, Biyonka Liang, B. Hann, 2019, Journal of Immunotherapy for Cancer.

Anti-integrin αvβ6 autoantibodies are a novel predictive biomarker in ulcerative colitis

B. Sands, J. Murray, D. Sheppard, 2022, bioRxiv.

IRE1α drives lung epithelial progenitor dysfunction to establish a niche for pulmonary fibrosis

F. R. Papa, D. Sheppard, H. Chapman, 2021, bioRxiv.

Loss of integrin αvβ6-mediated TGF-β activation causes Mmp12-dependent emphysema

N. Kaminski, D. Sheppard, S. Shapiro, 2003, Nature.

Cell division cycle 7 kinase is a negative regulator of cell-mediated collagen degradation.

Michael J. Podolsky, D. Sheppard, K. Atabai, 2018, American journal of physiology. Lung cellular and molecular physiology.

Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix

D. Sheppard, P. Wolters, H. Chapman, 2006, Proceedings of the National Academy of Sciences.

Gli1+ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung

D. Sheppard, P. Wolters, M. Matthay, 2020, Nature Cell Biology.

in Acute Respiratory Distress Syndrome Th17 Cells β α Unexpected Role for Adaptive

D. Sheppard, M. Matthay, D. McAuley, 2017 .

Unexpected Role for Adaptive αβTh17 Cells in Acute Respiratory Distress Syndrome

D. Sheppard, M. Matthay, D. McAuley, 2015, The Journal of Immunology.

Title Unexpected role for adaptive αβTh 17 cells in acute respiratory distress syndrome

D. Sheppard, M. Matthay, D. McAuley, 2015 .

IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction

D. Sheppard, Yanli Wang, M. Engler, 2012, Nature Medicine.

Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung

D. Sheppard, M. Nakanishi, J. Campisi, 2020, bioRxiv.

The EIIIA segment of fibronectin is a ligand for integrins alpha 9beta 1 and alpha 4beta 1 providing a novel mechanism for regulating cell adhesion by alternative splicing.

D. Sheppard, V. Koteliansky, Y. Liao, 2002, The Journal of biological chemistry.

Partial Inhibition of Integrin αvβ6 Prevents Pulmonary Fibrosis without Exacerbating Inflammation

Nicola J. Rinaldi, K. Simon, P. Weinreb, 2008 .

Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma.

P. Oettgen, Bingyan Wu, D. Sheppard, 2005, The Journal of clinical investigation.

Inactivation of the Integrin [36 Subunit Gene Reveals a Role of Epithelial Integrins in Regulating Inflammation in the Lungs and Skin

Robert V Farese, S. Young, D. Sheppard, 2002 .

Integrin α9β1 in airway smooth muscle suppresses exaggerated airway narrowing.

K. Shokat, D. Sheppard, P. Wolters, 2012, The Journal of clinical investigation.

IQGAP1-dependent scaffold suppresses RhoA and inhibits airway smooth muscle contraction.

D. Sheppard, K. Atabai, M. Bhattacharya, 2014, The Journal of clinical investigation.

Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients.

Yuanyuan Xiao, David Jablons, Kirk Jones, 2007, The Journal of clinical investigation.

Fibronectin and alpha5beta1 integrin mediate binding of Pseudomonas aeruginosa to repairing airway epithelium.

M. Plotkowski, J. Tournier, D. Sheppard, 1999, The European respiratory journal.

Fibronectin and a5b1 integrin mediate binding of Pseudomonas aeruginosa to repairing airway epithelium

M. Plotkowski, J. Tournier, D. Sheppard, 1999 .

OC-001 The Impact of the Introduction of Formalised Polypectomy Assessment on Training in the United Kingdom

D. Griggs, C. Betsholtz, J. Iredale, 2013, Gut.

The αvβ6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells.

D. Sheppard, D. Erle, Yanli Wang, 2012, The Journal of clinical investigation.

Gli1+ mesenchymal stromal cells modulate epithelial metaplasia in lung fibrosis

D. Sheppard, P. Wolters, M. Matthay, 2019, bioRxiv.

Selective αv integrin depletion identifies a core, targetable molecular pathway that regulates fibrosis across solid organs

D. Griggs, C. Betsholtz, J. Iredale, 2013, Nature Network Boston.

Functional Classification of ADAMs Based on a Conserved Motif for Binding to Integrin α9β1

E. Engvall, D. Sheppard, Y. Takada, 2002, The Journal of Biological Chemistry.

Therapy for Fibrotic Diseases: Nearing the Starting Line

S. Friedman, S. Violette, D. Sheppard, 2013, Science Translational Medicine.

Integrin β6 Mediates Phospholipid and Collectin Homeostasis by Activation of Latent TGF-β1

D. Sheppard, D. Erle, D. G. Morris, 2007 .

α-Smooth muscle actin is an inconsistent marker of fibroblasts responsible for force-dependent TGFβ activation or collagen production across multiple models of organ fibrosis.

D. Sheppard, Kai-Hui Sun, N. I. Reed, 2016, American journal of physiology. Lung cellular and molecular physiology.

Keratinocytes in Human Wounds Express αvβ6 Integrin

H. Larjava, T. Salo, K. Haapasalmi, 1996 .

Integrin αvβ5-Mediated TGF-β Activation by Airway Smooth Muscle Cells in Asthma

C. Brightling, D. Sheppard, A. Knox, 2011, The Journal of Immunology.

RGD-independent Binding of Integrin α9β1 to the ADAM-12 and -15 Disintegrin Domains Mediates Cell-Cell Interaction*

D. Sheppard, Y. Takada, A. Sehara-Fujisawa, 2000, The Journal of Biological Chemistry.

An essential role for fibronectin extra type III domain A in pulmonary fibrosis.

F. Martinez, D. Sheppard, K. Flaherty, 2008, American journal of respiratory and critical care medicine.

TGF-beta is a critical mediator of acute lung injury.

N. Kaminski, D. Sheppard, T. Geiser, 2001, The Journal of clinical investigation.

Loss of integrin alpha9beta1 results in defects in proliferation, causing poor re-epithelialization during cutaneous wound healing.

M. Stepp, D. Sheppard, Chun Chen, 2009, The Journal of investigative dermatology.

Cross talk among TGF-β signaling pathways, integrins, and the extracellular matrix.

D. Sheppard, J. Munger, 2011, Cold Spring Harbor perspectives in biology.

The cell biology of asthma

D. Sheppard, D. Erle, 2014, The Journal of cell biology.

The integrin αvβ8 mediates epithelial homeostasis through MT1-MMP–dependent activation of TGF-β1

D. Sheppard, D. Mu, H. Kawakatsu, 2002, The Journal of cell biology.

The Human Integrin α8β1 Functions as a Receptor for Tenascin, Fibronectin, and Vitronectin (*)

D. Sheppard, I. Klimanskaya, L. Schnapp, 1995, The Journal of Biological Chemistry.

TGF-β is a critical mediator of acute lung injury

Naftali Kaminski, Dean Sheppard, Mark J.D. Griffiths, 2001 .

ADAM disintegrin-like domain recognition by the lymphocyte integrins α4β1 and α4β7

D. Sheppard, Lance C Bridges, R. Bowditch, 2005 .

ADAM33 is not associated with asthma in Puerto Rican or Mexican populations.

P. Kwok, E. Silverman, E. Ziv, 2003, American journal of respiratory and critical care medicine.

Induction of a homeostatic circuit in lung tissue by microbial compounds.

D. Sheppard, E. Raz, Tomoko Hayashi, 2008, Immunity.

Dust mites' dirty dealings with dendritic cells

D. Sheppard, 2008, Nature Medicine.

Integrin-mediated activation of latent transforming growth factor β

Dean Sheppard, D. Sheppard, 2005, Cancer and Metastasis Reviews.

Expression of αvβ8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune encephalomyelitis in mice.

J. Bluestone, D. Sheppard, B. Fife, 2010, The Journal of clinical investigation.

Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction

Y. Jan, L. Jan, B. Hogan, 2012, Proceedings of the National Academy of Sciences.

Blocking TGFβ via Inhibition of the αvβ6 Integrin: A Possible Therapy for Systemic Sclerosis Interstitial Lung Disease

S. Violette, D. Sheppard, T. Katsumoto, 2011, International journal of rheumatology.

Loss of Integrin αvβ8 in Murine Hepatocytes Accelerates Liver Regeneration

Richard S. Taylor, J. Iredale, D. Sheppard, 2019, The American journal of pathology.

Integrin αvβ8 on T Cells is Responsible for Suppression of Anti-Tumor Immunity in Syngeneic Models and is a Promising Target for Tumor Immunotherapy

B. Hann, D. Sheppard, R. Akhurst, 2020 .

Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking αVβ8-TGFβ signaling in the brain

C. Betsholtz, D. Sheppard, R. Akhurst, 2014, Development.

Epistatic interactions between Tgfb1 and genetic loci, Tgfbm2 and Tgfbm3, determine susceptibility to an asthmatic stimulus

T. Tokuyasu, D. Sheppard, R. Akhurst, 2012, Proceedings of the National Academy of Sciences.

Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report.

H. Collard, K. Anstrom, F. Martinez, 2014, American journal of respiratory and critical care medicine.

Transforming Growth Factor β

D. Sheppard, 2012 .

Pulmonary emphysema: when more is less.

D. Sheppard, D. G. Morris, 2006, Physiology.

Transforming growth factor beta: a central modulator of pulmonary and airway inflammation and fibrosis.

D. Sheppard, Dean M. W. Sheppard, 2006, Proceedings of the American Thoracic Society.

The role of integrins in pulmonary fibrosis

D. Sheppard, 2008, European Respiratory Review.

Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation.

Nicola J. Rinaldi, K. Simon, P. Weinreb, 2008, American journal of respiratory and critical care medicine.

Cooperation between Cancer Cells and Regulatory T Cells to Promote Immune-escape through Integrin αvβ8-Mediated TGF-β Activation

D. Sheppard, S. Dalle, M. Travis, 2021 .

Broadly Conserved TMEM-131 Family Proteins in Collagen Production and Secretory Cargo Trafficking

Hao Li, T. Kornberg, Shuo Luo, 2019, bioRxiv.

Obesity alters pathology and treatment response in inflammatory disease

Chun Jimmie Ye, J. M. Suh, A. Marson, 2022, Nature.

The Integrin α9β1 Binds to a Novel Recognition Sequence (SVVYGLR) in the Thrombin-cleaved Amino-terminal Fragment of Osteopontin*

D. Sheppard, S. Higashiyama, Y. Yokosaki, 1999, The Journal of Biological Chemistry.

Spermidine/spermine N 1-acetyltransferase specifically binds to the integrin α9 subunit cytoplasmic domain and enhances cell migration

D. Sheppard, A. Pegg, C. Coleman, 2004, The Journal of cell biology.

Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma.

E. Silverman, E. Ziv, E. Burchard, 2005, American journal of respiratory and critical care medicine.

Distribution of integrins alpha v beta 6 and alpha 9 beta 1 and their known ligands, fibronectin and tenascin, in human airways.

D. Sheppard, R. Ferrando, M. Elliott, 1995, American journal of respiratory cell and molecular biology.

A stapled chromogranin A-derived peptide homes in on tumors that express αvβ6 or αvβ8 integrins

D. Sheppard, P. Rainone, A. Corti, 2023, International journal of biological sciences.

Identification of a Sequence within the Integrin β6 Subunit Cytoplasmic Domain That Is Required to Support the Specific Effect of αvβ6 on Proliferation in Three-dimensional Culture*

D. Sheppard, Aileen Chen, John J. Chen, 1996, The Journal of Biological Chemistry.

Integrins and Pulmonary Fibrosis

D. Sheppard, L. Koth, 2003 .

Normal Development, Wound Healing, and Adenovirus Susceptibility in β5-Deficient Mice

Robert V Farese, D. Sheppard, M. Griffiths, 2000, Molecular and Cellular Biology.

Thrombin-cleaved osteopontin regulates hemopoietic stem and progenitor cell functions through interactions with alpha9beta1 and alpha4beta1 integrins.

Cheang Ly Be, D. Sheppard, B. Williams, 2009, Blood.

IQGAP1 is necessary for pulmonary vascular barrier protection in murine acute lung injury and pneumonia.

A. Burlingame, D. Sheppard, X. Huang, 2012, American journal of physiology. Lung cellular and molecular physiology.

protection in murine acute lung injury and pneumonia IQGAP1 is necessary for pulmonary vascular barrier

A. Burlingame, D. Sheppard, M. Matthay, 2012 .

Function-blocking Integrin αvβ6 Monoclonal Antibodies

K. Simon, P. Weinreb, S. Violette, 2004, Journal of Biological Chemistry.

Alternaria Induces STAT6-Dependent Acute Airway Eosinophilia and Epithelial FIZZ1 Expression That Promotes Airway Fibrosis and Epithelial Thickness

D. Sheppard, M. Croft, D. Broide, 2012, The Journal of Immunology.

Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins.

D. Taverna, R. Hynes, D. Sheppard, 2002, Nature medicine.

Complete amino acid sequence of an integrin beta subunit (beta 7) identified in leukocytes.

D. Sheppard, C. Rüegg, D. Erle, 1991, The Journal of biological chemistry.

A disease-associated mutation in fibrillin-1 differentially regulates integrin-mediated cell adhesion

W. DeGrado, P. Handford, D. Sheppard, 2019, The Journal of Biological Chemistry.

Distinct roles for astrocyte alphavbeta5 and alphavbeta8 integrins in adhesion and migration.

D. Sheppard, X. Huang, C. ffrench-Constant, 1999, Journal of cell science.

Effective Treatment of Mouse Sepsis With an Inhibitory Antibody Targeting Integrin &agr;v&bgr;5*

D. Sheppard, M. Bhattacharya, A. Atakilit, 2013, Critical care medicine.

Arhgef12 drives IL17A-induced airway contractility and airway hyperresponsiveness in mice.

D. Sheppard, M. Thompson, Esther Wu, 2018, JCI insight.

Role of the Cytoplasmic Domain of the β-Subunit of Integrin αvβ6 in Infection by Foot-and-Mouth Disease Virus

D. Sheppard, T. Jackson, A. King, 2001, Journal of Virology.

Distinct roles for astrocyte αvβ5 and αvβ8 integrins in adhesion and migration

D. Sheppard, R. Milner, S. Nishimura, 1999 .

Complete amino acid sequence of a novel integrin beta subunit (beta 6) identified in epithelial cells using the polymerase chain reaction.

V. Quaranta, D. Sheppard, D. Erle, 1990, The Journal of biological chemistry.

Integrin αvβ6 Enhances Coxsackievirus B1 Lytic Infection of Human Colon Cancer Cells

D. Sheppard, X. Gu, M. Agrez, 1997 .

The Integrin alpha9beta1 contributes to granulopoiesis by enhancing granulocyte colony-stimulating factor receptor signaling.

S. Corey, D. Sheppard, Quan-sheng Zhu, 2006, Immunity.

RGD-independent binding of integrin alpha9beta1 to the ADAM-12 and -15 disintegrin domains mediates cell-cell interaction.

D. Sheppard, Y. Takada, A. Sehara-Fujisawa, 2000, The Journal of biological chemistry.

Genetic admixture and asthma‐related phenotypes in Mexican American and Puerto Rican asthmatics

N. Risch, P. Kwok, Hua Tang, 2005, Genetic epidemiology.

ITGB 1 Treg Th Treg Th ITGA 5 ITGB 3 Treg Th Treg Th ITGA 8 ITGB 5 Treg Th Treg Th ITGA 2 B ITGB 6 Treg Th Treg Th ITGB 8 Treg

D. Sheppard, P. Coulie, S. Nishimura, 2017 .

ROCKing pulmonary fibrosis.

D. Sheppard, 2013, The Journal of clinical investigation.

Pharmacologic Blockade of αvβ1 Integrin Ameliorates Renal Failure and Fibrosis In Vivo.

W. DeGrado, D. Sheppard, W. Lau, 2017, Journal of the American Society of Nephrology : JASN.

Expression of the integrin subunit α9 in the murine embryo

D. Sheppard, J. McDonald, L. Patrone, 1995 .

Mice Lacking the Integrin β5 Subunit Have Accelerated Osteoclast Maturation and Increased Activity in the Estrogen‐Deficient State

D. Sheppard, S. Teitelbaum, F. Ross, 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Enhanced pathological angiogenesis in mice lacking β3 integrin or β3 and β5 integrins

D. Taverna, R. Hynes, D. Sheppard, 2002, Nature Medicine.

IQGAP 1-dependent scaffold suppresses RhoA and inhibits airway smooth muscle contraction

D. Sheppard, K. Atabai, M. Bhattacharya, 2022 .

The epithelial integrin alphavbeta6 is a receptor for foot-and-mouth disease virus.

D. Sheppard, T. Jackson, A. King, 2000, Journal of virology.

The Integrin (cid:97) v (cid:98) 6 Binds and Activates Latent TGF (cid:98) 1: A Mechanism for Regulating Pulmonary Inflammation and Fibrosis

D. Sheppard, D. Rifkin, J. Pittet, 1999 .

A point mutation in the integrin beta 6 subunit abolishes both alpha v beta 6 binding to fibronectin and receptor localization to focal contacts.

D. Sheppard, X. Huang, M. Agrez, 1995, American journal of respiratory cell and molecular biology.

Activation of transforming growth factor-beta by the integrin alphavbeta8 delays epithelial wound closure.

D. Sheppard, C. Neurohr, S. Nishimura, 2006, American journal of respiratory cell and molecular biology.

Localized distribution of alpha 9 integrin in the cornea and changes in expression during corneal epithelial cell differentiation.

M. Stepp, D. Sheppard, R. Cranfill, 1995, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Fra-2 negatively regulates postnatal alveolar septation by modulating myofibroblast function.

E. Wagner, D. Sheppard, L. Bakiri, 2017, American journal of physiology. Lung cellular and molecular physiology.

Anti-integrin αvβ6 autoantibodies are a novel biomarker that antedate ulcerative colitis.

B. Sands, J. Murray, D. Sheppard, 2023, Gastroenterology.

ADAM disintegrin-like domain recognition by the lymphocyte integrins alpha4beta1 and alpha4beta7.

D. Sheppard, Lance C Bridges, R. Bowditch, 2005, Biochemical Journal.

Inhibitory Effects of MLDG-containing Heterodimeric Disintegrins Reveal Distinct Structural Requirements for Interaction of the Integrin α9β1 with VCAM-1, Tenascin-C, and Osteopontin*

J. Calvete, D. Sheppard, Y. Yokosaki, 2000, The Journal of Biological Chemistry.

Function-blocking integrin alphavbeta6 monoclonal antibodies: distinct ligand-mimetic and nonligand-mimetic classes.

K. Simon, P. Weinreb, S. Violette, 2004, The Journal of biological chemistry.

An integrated cell atlas of the lung in health and disease

Malte D. Luecken, Y. Bossé, M. Krasnow, 2023, Nature Medicine.

RESEARCH Biomarkers in Lung Diseases: from Pathogenesis to Prediction to New Therapies Transforming growth factor- (cid:2) plays divergent roles in modulating vascular remodeling, inﬂammation, and pulmonary ﬁbrosis in a murine model of scleroderma

D. Sheppard, A. Atakilit, X. Ren, 2016 .

Integrin beta6 mediates phospholipid and collectin homeostasis by activation of latent TGF-beta1.

D. Sheppard, D. Erle, D. G. Morris, 2007, American journal of respiratory cell and molecular biology.

Polarized regulation of fibronectin secretion and alternative splicing by transforming growth factor.

D. Cohen, D. Sheppard, E. Palmer, 1991, The Journal of biological chemistry.

Identification Of Biomarkers To Monitor The Activity Of STX-100, A Humanized Anti-±v²6 Antibody, In A Phase 2a Trial In Idiopathic Pulmonary Fibrosis

A. Prasse, S. Violette, N. Kaminski, 2012, ATS 2012.

IL-17 A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction

D. Sheppard, Yanli Wang, M. Engler, 2022 .

The lymphangiogenic growth factors VEGF-C and D are ligands for the integrin α 9 β 1 *

D. Sheppard, A. Atakilit, N. Vlahakis, 2008 .

Novel integrin alpha and beta subunit cDNAs identified in airway epithelial cells and lung leukocytes using the polymerase chain reaction.

D. Sheppard, C. Rüegg, J. Breuss, 1991, American journal of respiratory cell and molecular biology.

Expression of the integrin subunit alpha 9 in the murine embryo.

D. Sheppard, J. McDonald, L. Patrone, 1995, Developmental dynamics : an official publication of the American Association of Anatomists.

Transforming growth factor beta: a central modulator of pulmonary and airway inflammation and fibrosis.

D. Sheppard, Dean M. W. Sheppard, 2006 .

Fibronectin and its α5β1-integrin receptor are involved in the wound-repair process of airway epithelium

J. Zahm, H. Kaplan, D. Sheppard, 1996 .

Epithelial integrins

D. Sheppard, 1996, BioEssays : news and reviews in molecular, cellular and developmental biology.

CALL FOR PAPERS Translational Research in Acute Lung Injury and Pulmonary Fibrosis Inhibition of the (cid:2) v (cid:3) 6 integrin leads to limited alteration of TGF- (cid:2) -induced pulmonary ﬁbrosis

P. Weinreb, S. Violette, D. Sheppard, 2014 .

Interleukin-1 (cid:1) Causes Acute Lung Injury via (cid:2) v (cid:1) 5 and (cid:2) v (cid:1) 6 Integrin–Dependent Mechanisms Molecular Medicine

P. Weinreb, S. Violette, D. Sheppard, 2022 .

Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis

N. Kaminski, D. Sheppard, P. Wolters, 2020, Nature Communications.

Radial glia control microglial differentiation via integrin avb8-dependent trans-activation of TGFB1

E. Anton, D. Sheppard, O. Butovsky, 2023, bioRxiv.

Broadly conserved roles of TMEM131 family proteins in intracellular collagen assembly and secretory cargo trafficking

Hao Li, T. Kornberg, Shuo Luo, 2020, Science Advances.

Localization of the alpha v subfamily of integrins and their putative ligands in synovial lining cell layer.

H. Larjava, K. Haapasalmi, J. Heino, 1995, Journal of Rheumatology.

An immune-based tool platform for in vivo cell clearance

W. Lim, D. Sheppard, Jonathan S. Paw, 2023, Life Science Alliance.

The cell biology of asthma

D. Sheppard, D. Erle, 2014, The Journal of cell biology.

Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction

Y. Jan, L. Jan, B. Hogan, 2012, Proceedings of the National Academy of Sciences.

Integrin-mediated regulation of TGFβ in fibrosis.

D. Sheppard, N. Henderson, 2013, Biochimica et biophysica acta.

Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages.

Z. Werb, D. Sheppard, P. Wolters, 2009, The Journal of clinical investigation.

in Acute Respiratory Distress Syndrome Th17 Cells β α Unexpected Role for Adaptive

D. Sheppard, M. Matthay, D. McAuley, 2017 .

D. Sheppard, A. Atakilit, X. Ren, 2016 .

Selective αv integrin depletion identifies a core, targetable molecular pathway that regulates fibrosis across solid organs

D. Griggs, C. Betsholtz, J. Iredale, 2013, Nature Medicine.

Global analysis of gene expression in pulmonary fibrosis reveals distinct programs regulating lung inflammation and fibrosis.

David G. Morris, R. Heller, N. Kaminski, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Therapy for Fibrotic Diseases: Nearing the Starting Line

S. Friedman, S. Violette, D. Sheppard, 2013, Science Translational Medicine.

Expression of αvβ8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune encephalomyelitis in mice.

J. Bluestone, D. Sheppard, B. Fife, 2010, The Journal of clinical investigation.

The αvβ6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells.

D. Sheppard, D. Erle, Yanli Wang, 2012, The Journal of clinical investigation.

Effects of acidity and ozone on airway epithelium. Final report

D. Sheppard, R. Cone, S. Cohen, 1991 .

D. Sheppard, C. Rüegg, R. Pytela, 1993, The Journal of cell biology.

inflammation and

Robert V Farese, S. Young, D. Sheppard, 2002 .

α-Smooth muscle actin is an inconsistent marker of fibroblasts responsible for force-dependent TGFβ activation or collagen production across multiple models of organ fibrosis.

D. Sheppard, Kai-Hui Sun, N. I. Reed, 2016, American journal of physiology. Lung cellular and molecular physiology.

Epithelial and Mesenchymal Cell Biology v 6 Integrin Regulates Renal Fibrosis and Inflammation in Alport Mouse

K. Simon, P. Weinreb, S. Violette, 2006 .

Integrin α9β1 in airway smooth muscle suppresses exaggerated airway narrowing.

K. Shokat, D. Sheppard, P. Wolters, 2012, The Journal of clinical investigation.

TRAITEMENT DE LA FIBROSE OU DE LESIONS PULMONAIRES AIGUES AU MOYEN D'ANTAGONISTES DE αvβ6

D. Sheppard, R. Pytela, Xiaozhu Huang, 1998 .

Spermidine/spermine N 1 -acetyltransferase speciﬁcally binds to the integrin (cid:1) 9 subunit cytoplasmic domain and enhances cell migration

D. Sheppard, A. Pegg, C. Coleman, 2004 .