P. Hagerman

Lexin Li, P. Hagerman, A. Brusco, 2007, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

Current Gaps in Understanding the Molecular Basis of FXTAS

P. Hagerman, 2012, Tremor and other hyperkinetic movements.

Gel electrophoretic analysis of the geometry of a DNA four-way junction.

P. Hagerman, J. Cooper, P J Hagerman, 1987, Journal of molecular biology.

Sam68 sequestration and partial loss of function are associated with splicing alterations in FXTAS patients

S. Richard, P. Hagerman, R. Willemsen, 2010, The EMBO journal.

Systematic characterization of high mass accuracy influence on false discovery and probability scoring in peptide mass fingerprinting.

Eric D. Dodds, P. Hagerman, C. Lebrilla, 2008, Analytical biochemistry.

The effect of pre-mutation of X chromosome CGG trinucleotide repeats on brain anatomy.

P. McGuire, J. Suckling, C. Moore, 2004, Brain : a journal of neurology.

Male Carriers of the FMR1 Premutation Show Altered Hippocampal-Prefrontal Function During Memory Encoding

S. Rivera, R. Hashimoto, P. Hagerman, 2012, Front. Hum. Neurosci..

Decreased Fragile X Mental Retardation Protein Expression Underlies Amygdala Dysfunction in Carriers of the Fragile X Premutation

Andrea Schneider, Kami Koldewyn, Flora Tassone, 2011, Biological Psychiatry.

A Quantitative Assessment of Tremor and Ataxia in Female FMR1 Premutation Carriers Using CATSYS

Danh V. Nguyen, Flora Tassone, Randi J. Hagerman, 2011, Current gerontology and geriatrics research.

Fragile X syndrome and fragile X-associated tremor/ataxia syndrome

P. Hagerman, R. Hagerman, 2006 .

Transcription of the FMR1 gene in individuals with fragile X syndrome.

P. Hagerman, F. Tassone, R. Hagerman, 2000, American journal of medical genetics.

Clinical involvement and protein expression in individuals with the FMR1 premutation.

P. Hagerman, A. Taylor, F. Tassone, 2000, American journal of medical genetics.

Flexibility of RNA.

P. Hagerman, P J Hagerman, Paul J. Hagerman, 1997, Annual review of biophysics and biomolecular structure.

Cytosine methylation can induce local distortions in the structure of duplex DNA.

P. Hagerman, Y. Hodges-Garcia, Paul J. Hagerman, 1992, Biochemistry.

Investigation of the Influence of Cytosine Methylation on DNA Flexibility (*)

P. Hagerman, Y. Hodges-Garcia, Yvonne Hodges-Garcia, 1995, The Journal of Biological Chemistry.

The FMR1 CGG repeat mouse displays ubiquitin-positive intranuclear neuronal inclusions; implications for the cerebellar tremor/ataxia syndrome.

Mariette Schrier, J. Holstege, B. Oostra, 2003, Human molecular genetics.

Monte Carlo approach to the analysis of the rotational diffusion of wormlike chains

B. Zimm, P. Hagerman, 1981 .

Fragile X-associated tremor/ataxia syndrome: pathophysiology and management

P. Hagerman, R. Hagerman, 2021, Current opinion in neurology.

Expanded clinical phenotype of women with the FMR1 premutation

D. Nguyen, P. Hagerman, F. Tassone, 2008, American journal of medical genetics. Part A.

Composition of the Intranuclear Inclusions of Fragile X-associated Tremor/Ataxia Syndrome

P. Hagerman, R. Hagerman, A. Herren, 2019, Acta Neuropathologica Communications.

From sequence to structure to function.

Ignacio Tinoco, I. Tinoco, P. Hagerman, 1996, Current opinion in structural biology.

Application of transient electric birefringence to the study of biopolymer structure.

P. Hagerman, 1985, Methods in enzymology.

CGG-repeat length threshold for FMR1 RNA pathogenesis in a cellular model for FXTAS.

P. Hagerman, F. Tassone, C. Iwahashi, 2011, Human molecular genetics.

Intranuclear inclusions in neural cells with premutation alleles in fragile X associated tremor/ataxia syndrome

É. Khandjian, P. Hagerman, F. Tassone, 2004, Journal of Medical Genetics.

Sometimes a great motion: the application of transient electric birefringence to the study of macromolecular structure.

P. Hagerman, 1996, Current opinion in structural biology.

Fragile X males with unmethylated, full mutation trinucleotide repeat expansions have elevated levels of FMR1 messenger RNA.

D. Loesch, P. Hagerman, A. Taylor, 2000, American journal of medical genetics.

Reduced telomere length in older men with premutation alleles of the fragile X mental retardation 1 gene

W. Brown, Hong Gu, P. Hagerman, 2008, American journal of medical genetics. Part A.

Transient electric birefringence for determining global conformations of nonhelix elements and protein-induced bends in RNA.

P. Hagerman, 2000, Methods in enzymology.

The bend in RNA created by the trans-activation response element bulge of human immunodeficiency virus is straightened by arginine and by Tat-derived peptide.

M. Zacharias, P. Hagerman, M. Zacharias, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Incomplete financial disclosure in a commentary on testing for fragile X gene mutations throughout the life span.

P. Hagerman, 2009, JAMA.

Analysis of birefringence decay profiles for nucleic acid helices possessing bends: the tau-ratio approach.

P. Hagerman, E. Vacano, 1997, Biophysical journal.

Testicular and pituitary inclusion formation in fragile X associated tremor/ataxia syndrome.

P. Hagerman, R. Hagerman, C. Greco, 2007, The Journal of urology.

Prevalence of FMR1 Repeat Expansions in Movement Disorders

P. Hagerman, D. Hall, R. Hagerman, 2006, Neuroepidemiology.

Fragile X-associated tremor/ataxia syndrome.

P. Hagerman, M. Leehey, 2012, Handbook of clinical neurology.

Symptomatic treatment in the fragile X–associated tremor/ataxia syndrome

P. Hagerman, D. Hall, R. Hagerman, 2006, Movement disorders : official journal of the Movement Disorder Society.

Screen for expanded FMR1 alleles in patients with essential tremor

T. Gilliam, P. Hagerman, E. Louis, 2004, Movement disorders : official journal of the Movement Disorder Society.

Concomitant occurrence of FXTAS and clinically defined sporadic inclusion body myositis: report of two cases

P. Hagerman, S. Tisch, M. Hunsaker, 2017, Croatian medical journal.

Pathophysiology of Epilepsy in Autism Spectrum Disorders

P. Hagerman, C. Stafstrom, I. Pessah, 2012 .

Persistence length of RNA.

D. Draper, P. Hagerman, P. Kebbekus, 1995, Biochemistry.

Isolation of pathology-associated intranuclear inclusions.

P. Hagerman, C. Iwahashi, Christine Iwahashi, 2008, Methods in molecular biology.

A majority of fragile X males with methylated, full mutation alleles have significant levels of FMR1messenger RNA

P. Hagerman, A. Taylor, F. Tassone, 2001, Journal of medical genetics.

Reversibility of neuropathology and motor deficits in an inducible mouse model for FXTAS.

C. D. De Zeeuw, P. Hagerman, M. Schonewille, 2015, Human molecular genetics.

Transcription-associated R-loop formation across the human CGG-repeat region.

F. Chédin, P. Hagerman, L. Sanz, 2014 .

11 – RNA-Based Disorders of Muscle and Brain

P. Hagerman, 2007 .

of the mRNA is not influenced by AGG interruptions.

P. Hagerman, J. Hershey, F. Tassone, 2009 .

BMC Technical advance Neural progenitor cells from an adult patient with fragile X syndrome

P. Hagerman, F. Tassone, R. Hagerman, 2005 .

Fragmentation of singly protonated peptides via a combination of infrared and collisional activation.

Eric D. Dodds, P. Hagerman, C. Lebrilla, 2006, Analytical chemistry.

Helix rigidity of DNA: the meroduplex as an experimental paradigm.

P. Hagerman, K. Hagerman, 1996, Journal of molecular biology.

Electrophoretic evidence that single-stranded regions of one or more nucleotides dramatically increase the flexibility of DNA.

P. Hagerman, J. Mills, J. Cooper, 1994, Biochemistry.

A quantitative ELISA assay for the fragile x mental retardation 1 protein.

D. Nguyen, P. Hagerman, F. Tassone, 2009, The Journal of molecular diagnostics : JMD.

A cerebellar tremor/ataxia syndrome among fragile X premutation carriers

P. Hagerman, R. Hagerman, R. Hagerman, 2003, Cytogenetic and Genome Research.

Expression of the FMR1 gene

P. Hagerman, F. Tassone, 2003, Cytogenetic and Genome Research.

Widespread non-central nervous system organ pathology in fragile X premutation carriers with fragile X-associated tremor/ataxia syndrome and CGG knock-in mice

Michael R. Hunsaker, P. Hagerman, M. Hunsaker, 2011, Acta Neuropathologica.

Testing for fragile X gene mutations throughout the life span.

P. Hagerman, R. Hagerman, 2008, JAMA.

Tremor/Ataxia syndrome in fragile X carrier males

W. Landau, P. Hagerman, F. Tassone, 2002 .

AGG interruptions within the maternal FMR1 gene reduce the risk of offspring with fragile X syndrome

D. Nelson, P. Hagerman, F. Tassone, 2012, Genetics in Medicine.

An information-rich CGG repeat primed PCR that detects the full range of fragile X expanded alleles and minimizes the need for southern blot analysis.

E. Sekinger, P. Hagerman, F. Tassone, 2010, The Journal of molecular diagnostics : JMD.

Induced expression of expanded CGG RNA causes mitochondrial dysfunction in vivo

P. Hagerman, J. Kros, R. Willemsen, 2014, Cell cycle.

Intranuclear inclusions in a fragile X mosaic male

Dalyir I. Pretto, Michael R. Hunsaker, P. Hagerman, 2013, Translational Neurodegeneration.

A neuropsychological investigation of male premutation carriers of fragile X syndrome

C. Moore, D. Murphy, E. Daly, 2004, Neuropsychologia.

Microglial cell activation and senescence are characteristic of the pathology FXTAS

P. Hagerman, M. Lechpammer, F. Tassone, 2018, Movement disorders : official journal of the Movement Disorder Society.

Psychological symptoms correlate with reduced hippocampal volume in fragile X premutation carriers

S. Rivera, C. Decarli, J. Brunberg, 2009, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

Neuropathy as a presenting feature in fragile X‐associated tremor/ataxia syndrome

J. Brunberg, Lin Zhang, P. Hagerman, 2007, American journal of medical genetics. Part A.

Spastic paraparesis, cerebellar ataxia, and intention tremor: a severe variant of FXTAS?

J. Brunberg, P. Hagerman, S. Jacquemont, 2005, Journal of Medical Genetics.

Sequencing the unsequenceable: Expanded CGG-repeat alleles of the fragile X gene

Sarah McCalmon, Flora Tassone, Paul Peluso, 2013, Genome research.

Fragile X Syndrome

P. Hagerman, F. Tassone, R. Hagerman, 2014, Colombia medica.

Initial diagnoses given to persons with the fragile X associated tremor/ataxia syndrome (FXTAS)

P. Hagerman, D. Hall, S. Jacquemont, 2005, Neurology.

Iron accumulation and dysregulation in the putamen in fragile X‐associated tremor/ataxia syndrome

P. Hagerman, V. Martínez‐Cerdeño, Jeanelle Ariza, 2017, Movement disorders : official journal of the Movement Disorder Society.

Epilepsy in autism spectrum disorders

P. Hagerman, C. Stafstrom, I. Pessah, 2010 .

A general method for cloning DNA fragments in multiple copies.

P. Hagerman, W. H. Taylor, 1987, Gene.

Elevated levels of FMR1 mRNA in carrier males: a new mechanism of involvement in the fragile-X syndrome.

T. Godfrey, P. Hagerman, A. Taylor, 2000, American journal of human genetics.

Single-locus enrichment without amplification for sequencing and direct detection of epigenetic modifications

S. Turner, J. Eid, T. Pham, 2016, Molecular Genetics and Genomics.

Abnormal nerve conduction features in fragile X premutation carriers.

P. Hagerman, R. Maselli, F. Tassone, 2008, Archives of neurology.

Autism profiles of males with fragile X syndrome.

P. Hagerman, D. Hessl, F. Tassone, 2008, American journal of mental retardation : AJMR.

Murine hippocampal neurons expressing Fmr1 gene premutations show early developmental deficits and late degeneration.

P. Hagerman, R. Willemsen, F. Tassone, 2010, Human molecular genetics.

Kinetic analysis of the reversible folding reactions of small proteins: Application to the folding of lysozyme and cytochrome c

P. Hagerman, Paul J. Hagerman, 1977, Biopolymers.

Analysis of fluorescence energy transfer in duplex and branched DNA molecules.

P. Hagerman, J. Cooper, P J Hagerman, 1990, Biochemistry.

Luminescence of paracyclophanes I. syn- and anti-[2.2] paracyclonaphthane

P. Hagerman, J. Froines, 1969 .

Investigation of the flexibility of DNA using transient electric birefringence

P. Hagerman, P J Hagerman, 1981, Biopolymers.

Sequence-directed curvature of DNA.

P. Hagerman, P J Hagerman, Paul J. Hagerman, 1986, Nature.

Interstrand psoralen cross-links do not introduce appreciable bends in DNA.

R. Sinden, P. Hagerman, 1984, Biochemistry.

Evidence for the existence of stable curvature of DNA in solution.

P. Hagerman, P J Hagerman, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Fragile X-associated tremor/ataxia syndrome (FXTAS): pathology and mechanisms

P. Hagerman, 2013, Acta Neuropathologica.

Sequestration of DROSHA and DGCR8 by expanded CGG RNA repeats alters microRNA processing in fragile X-associated tremor/ataxia syndrome.

Peter K. Todd, M. Disney, P. Hagerman, 2013, Cell reports.

The Fragile X Syndrome: History, Diagnosis, and Treatment

P. Hagerman, R. Hagerman, P. McBogg, 1983, Journal of developmental and behavioral pediatrics : JDBP.

Fragile X‐associated tremor/ataxia syndrome: Clinical features, genetics, and testing guidelines

J. Brunberg, Lin Zhang, P. Hagerman, 2007, Movement disorders : official journal of the Movement Disorder Society.

Recent advances in fragile X: a model for autism and neurodegeneration

P. Hagerman, R. Hagerman, Randi J Hagerman, 2005, Current opinion in psychiatry.

Elevated FMR1-mRNA and lowered FMRP – A double-hit mechanism for psychiatric features in men with FMR1 premutations

P. Hagerman, A. Schneider, F. Tassone, 2020, Translational Psychiatry.

Fragile X-associated tremor/ataxia syndrome — features, mechanisms and management

P. Hagerman, R. Hagerman, 2016, Nature Reviews Neurology.

Elevated FMR1 mRNA in premutation carriers is due to increased transcription.

Lexin Li, P. Hagerman, C. Bagni, 2007, RNA.

Penetrance of the fragile X-associated tremor/ataxia syndrome in a premutation carrier population.

J. Brunberg, Lin Zhang, P. Hagerman, 2004, JAMA.

Sequence-Dependent Curvature of DNA

P. Hagerman, 1988 .

Fragile X and autism: Intertwined at the molecular level leading to targeted treatments

P. Hagerman, R. Hagerman, Randi Hagerman, 2010, Molecular autism.

Differential increases of specific FMR1 mRNA isoforms in premutation carriers

Dalyir I. Pretto, J. Eid, P. Hagerman, 2014, Journal of Medical Genetics.

Immune‐mediated disorders among women carriers of fragile X premutation alleles

D. Nguyen, P. Hagerman, F. Tassone, 2012, American journal of medical genetics. Part A.

Redistribution of transcription start sites within the FMR1 promoter region with expansion of the downstream CGG-repeat element.

P. Hagerman, A. Beilina, F. Tassone, 2004, Human molecular genetics.

Reduced FMR1 mRNA translation efficiency in fragile X patients with premutations.

P. Hagerman, F. Amaldi, C. Bagni, 2002, RNA.

Prenatal Diagnosis and the Spectrum of Involvement from Fragile X Mutations

P. Hagerman, R. Hagerman, 2021, Genetic Disorders and the Fetus.

Autism phenotype in fragile X premutation males is not associated with FMR1 expression: a preliminary evaluation

D. Nguyen, P. Hagerman, F. Tassone, 2018 .

Signaling defects in iPSC-derived fragile X premutation neurons.

P. Hagerman, R. Hagerman, I. Pessah, 2012, Human molecular genetics.

Origins of Epilepsy in Fragile X Syndrome

P. Hagerman, C. Stafstrom, Carl E. Stafstrom, 2009, Epilepsy currents.

Translation of the FMR1 mRNA is not influenced by AGG interruptions

P. Hagerman, J. Hershey, F. Tassone, 2009, Nucleic acids research.

Expression of an expanded CGG-repeat RNA in a single pair of primary sensory neurons impairs olfactory adaptation in Caenorhabditis elegans

P. Hagerman, N. L’Etoile, Anna L. Ludwig, 2014, Human molecular genetics.

Expression of an expanded CGG-repeat RNA in a single pair of primary sensory neurons impairs olfactory adaptation in C . elegans

P. Hagerman, N. L’Etoile, Anna L. Ludwig, 2014 .

Secondary Structure and Dynamics of the r(CGG) Repeat in the mRNA of the Fragile X Mental Retardation 1 (FMR1) Gene

P. Hagerman, T. Dieckmann, Anna L. Ludwig, 2007, RNA biology.

Origin of the intrinsic rigidity of DNA.

P. Hagerman, J. Mills, Paul J Hagerman, 2004, Nucleic acids research.

Association between IQ and FMR1 protein (FMRP) across the spectrum of CGG repeat expansions

P. Hagerman, D. Hessl, A. Schneider, 2019, PloS one.

Size and methylation mosaicism in males with Fragile X syndrome

P. Hagerman, F. Tassone, R. Hagerman, 2017, Expert review of molecular diagnostics.

FMR1 premutation and full mutation molecular mechanisms related to autism

P. Hagerman, J. Au, R. Hagerman, 2011, Journal of Neurodevelopmental Disorders.

Early onset of neurological symptoms in fragile X premutation carriers exposed to neurotoxins.

J. Brunberg, D. Nguyen, P. Hagerman, 2010, Neurotoxicology.

Clinical and molecular implications of mosaicism in FMR1 full mutations

Dalyir I. Pretto, Flora Tassone, Blythe Durbin-Johnson, 2014, Front. Genet..

A novel FMR1 PCR method for the routine detection of low abundance expanded alleles and full mutations in fragile X syndrome.

E. Sekinger, P. Hagerman, F. Tassone, 2010, Clinical chemistry.

A Novel FMR 1 PCR Method for the Routine Detection of Low-Abundance Expanded Alleles and Full Mutations in Fragile X Syndrome

E. Sekinger, P. Hagerman, F. Tassone, 2010 .

A rapid polymerase chain reaction-based screening method for identification of all expanded alleles of the fragile X (FMR1) gene in newborn and high-risk populations.

P. Hagerman, F. Tassone, Khaled M. A. Amiri, 2008, The Journal of molecular diagnostics : JMD.

Impairment in the cognitive functioning of men with fragile X-associated tremor/ataxia syndrome (FXTAS)

D. Loesch, P. Hagerman, S. Jacquemont, 2006, Journal of the Neurological Sciences.

Neuronal intranuclear inclusions in a new cerebellar tremor/ataxia syndrome among fragile X carriers.

M. D. Del Bigio, P. Hagerman, S. Jacquemont, 2002, Brain : a journal of neurology.

Clinical and molecular correlates in fragile X premutation females

S. Rivera, P. Hagerman, D. Hessl, 2017, eNeurologicalSci.

Testing the FMR 1 Promoter for Mosaicism in DNA Methylation among CpG Sites , Strands , and Cells in FMR 1-Expressing Males with Fragile X Syndrome

P. Hagerman, F. Tassone, R. Hagerman, 2016 .

CNS expression of murine fragile X protein (FMRP) as a function of CGG-repeat size.

Dalyir I. Pretto, P. Hagerman, F. Tassone, 2014, Human molecular genetics.

Testing the FMR1 Promoter for Mosaicism in DNA Methylation among CpG Sites, Strands, and Cells in FMR1-Expressing Males with Fragile X Syndrome

P. Hagerman, F. Tassone, R. Hagerman, 2011, PloS one.

FMR1 CGG repeat length predicts motor dysfunction in premutation carriers

C. Goetz, P. Hagerman, D. Hall, 2008, Neurology.

Molecular and imaging correlates of the fragile X–associated tremor/ataxia syndrome

Katherine E. Masyn, S. Rivera, D. Loesch, 2006, Neurology.

Size bias of fragile X premutation alleles in late-onset movement disorders

L. Beckett, P. Hagerman, S. Jacquemont, 2006, Journal of Medical Genetics.

Autism Spectrum Disorders and Attention-Deficit/Hyperactivity Disorder in Boys with the Fragile X Premutation

D. Loesch, P. Hagerman, F. Farzin, 2006, Journal of developmental and behavioral pediatrics : JDBP.

Abnormal elevation of FMR1 mRNA is associated with psychological symptoms in individuals with the fragile X premutation

D. Loesch, P. Hagerman, D. Hessl, 2005, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

FMR1 RNA within the Intranuclear Inclusions of Fragile X-Associated Tremor/Ataxia Syndrome (FXTAS)

P. Hagerman, F. Tassone, C. Iwahashi, 2004, RNA biology.

The fragile-X premutation: a maturing perspective.

P. Hagerman, R. Hagerman, 2004, American journal of human genetics.

Single-locus enrichment without amplification for sequencing and direct detection of epigenetic modifications

S. Turner, J. Eid, T. Pham, 2016, Molecular Genetics and Genomics.

Structural studies of the tRNA domain of tmRNA.

S. Harvey, S. Stagg, P. Hagerman, 2001, Journal of molecular biology.

Early mitochondrial abnormalities in hippocampal neurons cultured from Fmr1 pre‐mutation mouse model

P. Hagerman, F. Tassone, I. Pessah, 2012, Journal of neurochemistry.

Premutation CGG-repeat expansion of the Fmr1 gene impairs mouse neocortical development.

P. Hagerman, R. Willemsen, I. Pessah, 2011, Human molecular genetics.

High-resolution methylation polymerase chain reaction for fragile X analysis: Evidence for novel FMR1 methylation patterns undetected in Southern blot analyses

P. Hagerman, F. Tassone, Sachin Sah, 2011, Genetics in Medicine.

Fragile-X-associated tremor/ataxia syndrome (FXTAS) in females with the FMR1 premutation.

L Zhang, J Grigsby, B. Leavitt, 2004, American journal of human genetics.

Fragile X syndrome: a model of gene-brain-behavior relationships.

P. Hagerman, R. Hagerman, 2001, Molecular genetics and metabolism.

Protein composition of the intranuclear inclusions of FXTAS.

P. Hagerman, C. Lebrilla, F. Tassone, 2006, Brain : a journal of neurology.

An enhanced polymerase chain reaction assay to detect pre- and full mutation alleles of the fragile X mental retardation 1 gene.

P. Hagerman, A. Brusco, F. Tassone, 2005, The Journal of molecular diagnostics : JMD.

Fragile X premutation tremor/ataxia syndrome: molecular, clinical, and neuroimaging correlates.

W. Brown, J. Brunberg, Lin Zhang, 2003, American journal of human genetics.

Expansion of an FMR1 grey-zone allele to a full mutation in two generations.

P. Hagerman, F. Tassone, Ruiqin Pan, 2009, The Journal of molecular diagnostics : JMD.

Fragile-X syndrome and fragile X-associated tremor/ataxia syndrome: two faces of FMR1

P. Hagerman, S. Jacquemont, R. Hagerman, 2007, The Lancet Neurology.

Astroglial-targeted expression of the fragile X CGG repeat premutation in mice yields RAN translation, motor deficits and possible evidence for cell-to-cell propagation of FXTAS pathology

P. Hagerman, M. Hunsaker, R. Willemsen, 2019, Acta neuropathologica communications.

Calcium dysregulation and Cdk5-ATM pathway involved in a mouse model of fragile X-associated tremor/ataxia syndrome

P. Hagerman, I. Pessah, José R Lopez, 2017, Human molecular genetics.

Abnormal semantic processing in females with fragile X‐associated tremor/ataxia syndrome

P. Hagerman, J. Olichney, L. Hamilton, 2014, Genes, brain, and behavior.

AWARD NUMBER: W81XWH-13-1-0150 TITLE: Targeted Upregulation of FMRP Expression as an Approach to the Treatment of Fragile X Syndrome

P. Hagerman, I. Pessah, 2014 .

Enhanced Asynchronous Ca2+ Oscillations Associated with Impaired Glutamate Transport in Cortical Astrocytes Expressing Fmr1 Gene Premutation Expansion*

P. Hagerman, F. Tassone, I. Pessah, 2013, The Journal of Biological Chemistry.

Clustered burst firing in FMR1 premutation hippocampal neurons: amelioration with allopregnanolone.

Flora Tassone, Zhengyu Cao, Michael A Rogawski, 2012, Human molecular genetics.

Differential usage of transcriptional start sites and polyadenylation sites in FMR1 premutation alleles

P. Hagerman, C. Bagni, R. Willemsen, 2011, Nucleic acids research.

Evidence of mitochondrial dysfunction in fragile X-associated tremor/ataxia syndrome.

Sarah Wong, P. Hagerman, C. Giulivi, 2010, The Biochemical journal.

Advances in understanding the molecular basis of FXTAS.

P. Hagerman, D. Garcia-Arocena, 2010, Human molecular genetics.

Fibroblast phenotype in male carriers of FMR1 premutation alleles.

C. Goetz, D. Nguyen, P. Hagerman, 2010, Human molecular genetics.

Molecular Pathogenesis of Fragile X-Associated Tremor/Ataxia Syndrome

P. Hagerman, Christopher Raske, 2009, Journal of Investigative Medicine.

Covariate Adjusted Correlation Analysis with Application to FMR1 Premutation Female Carrier Data

Raymond J Carroll, Damla Sentürk, Danh V Nguyen, 2009, Biometrics.

The primary cognitive deficit among males with fragile X-associated tremor/ataxia syndrome (FXTAS) is a dysexecutive syndrome

P. Hagerman, D. Hessl, F. Tassone, 2008, Journal of clinical and experimental neuropsychology.

Clinical and neuropathologic findings in a woman with the FMR1 premutation and multiple sclerosis.

J. Brunberg, P. Hagerman, F. Tassone, 2008, Archives of neurology.

Age-dependent cognitive changes in carriers of the fragile X syndrome

Lexin Li, P. Hagerman, A. Dalton, 2008, Cortex.

Cognitive profile of fragile X premutation carriers with and without fragile X-associated tremor/ataxia syndrome.

P. Hagerman, D. Hessl, D. Hall, 2008, Neuropsychology.

Screen for excess FMR1 premutation alleles among males with parkinsonism.

P. Hagerman, R. Cilia, F. Tassone, 2007, Archives of neurology.

Progression of tremor and ataxia in male carriers of the FMR1 premutation

Lin Zhang, P. Hagerman, D. Hessl, 2007, Movement disorders : official journal of the Movement Disorder Society.

Aging in individuals with the FMR1 mutation.

Lin Zhang, P. Hagerman, F. Farzin, 2004, American journal of mental retardation : AJMR.

The fragile X premutation: into the phenotypic fold.

P. Hagerman, R. Hagerman, 2002, Current opinion in genetics & development.

The 5'-untranslated region of the FMR1 message facilitates translation by internal ribosome entry.

P. Hagerman, P J Hagerman, P W Chiang, 2001, The Journal of biological chemistry.

REVIEW ARTICLE The Fragile-X Premutation: A Maturing Perspective

P. Hagerman, R. Hagerman, 2004 .

Application of the method of phage T4 DNA ligase-catalyzed ring-closure to the study of DNA structure. II. NaCl-dependence of DNA flexibility and helical repeat.

P. Hagerman, W. Taylor, W H Taylor, 1990, Journal of molecular biology.

Transcription-Associated R-Loop Formation across the Human FMR1 CGG-Repeat Region

F. Chédin, P. Hagerman, L. Sanz, 2014, PLoS genetics.

The angle between the anticodon and aminoacyl acceptor stems of yeast tRNA(Phe) is strongly modulated by magnesium ions.

P. Hagerman, M. Friederich, 1997, Biochemistry.

Fragile X-associated tremor/ataxia syndrome—an older face of the fragile X gene

P. Hagerman, R. Hagerman, 2007, Nature Clinical Practice Neurology.

DNA ring closure mediated by protein HU.

P. Hagerman, D. Pettijohn, Y. Hodges-Garcia, 1989, The Journal of biological chemistry.

The (CGG)n repeat element within the 5' untranslated region of the FMR1 message provides both positive and negative cis effects on in vivo translation of a downstream reporter.

P. Hagerman, F. Tassone, Li-Sheng Chen, 2003, Human molecular genetics.

Reduced telomere length in individuals with FMR1 premutations and full mutations

P. Hagerman, F. Tassone, R. Hagerman, 2012, American journal of medical genetics. Part A.

Sequence dependence of the curvature of DNA: a test of the phasing hypothesis.

P. Hagerman, Paul J. Hagerman, 1985, Biochemistry.

Straightening out the bends in curved DNA.

P. Hagerman, 1992, Biochimica et biophysica acta.

Pyrimidine 5-methyl groups influence the magnitude of DNA curvature.

P. Hagerman, 1990, Biochemistry.

Molecular Correlates of Fragile X Syndrome and FXTAS

P. Hagerman, F. Tassone, 2006 .

Application of the method of phage T4 DNA ligase-catalyzed ring-closure to the study of DNA structure. I. Computational analysis.

P. Hagerman, P J Hagerman, V A Ramadevi, 1990, Journal of molecular biology.

Electrophoretic and hydrodynamic properties of duplex ribonucleic acid molecules transcribed in vitro: evidence that A-tracts do not generate curvature in RNA.

P. Hagerman, F. Gast, 1991, Biochemistry.

Analysis of the ring‐closure probabilities of isotropic wormlike chains: Application to duplex DNA

P. Hagerman, P J Hagerman, 1985, Biopolymers.

Oral folic acid versus placebo in the treatment of males with the fragile X syndrome.

P. Hagerman, R. Hagerman, L. Mcgavran, 1986, American journal of medical genetics.

Cognitive impairment in a 65-year-old male with the fragile X-associated tremor-ataxia syndrome (FXTAS).

J. Brunberg, P. Hagerman, S. Jacquemont, 2006, Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology.

Variation of the acceptor-anticodon interstem angles among mitochondrial and non-mitochondrial tRNAs.

P. Hagerman, A. Frazer-Abel, 2004, Journal of molecular biology.

Altered zinc transport disrupts mitochondrial protein processing/import in fragile X-associated tremor/ataxia syndrome.

Sarah Wong, P. Hagerman, C. Giulivi, 2011, Human molecular genetics.

Enhanced peptide mass fingerprinting through high mass accuracy: Exclusion of non-peptide signals based on residual mass.

Eric D. Dodds, Hyun Joo An, P. Hagerman, 2006, Journal of proteome research.

Neuropathologic features in the hippocampus and cerebellum of three older men with fragile X syndrome

Michael R. Hunsaker, C. Schumann, P. Hagerman, 2011, Molecular autism.

The relationship between uracil incorporation into DNA and the expression of fragile sites in human.

P. Hagerman, 1984, American journal of medical genetics.

Fragile X syndrome and connective tissue dysregulation

P. Hagerman, C. Páyan-Gomez, R. Hagerman, 2018, Clinical genetics.

Bovine Myoclonus: Model of Human Hyperekplexia (Startle Disease)

W. Landau, P. Hagerman, F. Tassone, 2002 .

Investigation of amygdala volume in men with the fragile X premutation

D. Harvey, S. Rivera, P. Hagerman, 2011, Brain Imaging and Behavior.

A review of fragile X premutation disorders: expanding the psychiatric perspective.

S. Rivera, P. Hagerman, D. Hessl, 2009, The Journal of clinical psychiatry.

The Fragile X Family of Disorders: A Model for Autism and Targeted Treatments

S. Rivera, P. Hagerman, R. Hagerman, 2008 .

Reduced Hippocampal Activation During Recall is Associated with Elevated FMR1 mRNA and Psychiatric Symptoms in Men with the Fragile X Premutation

S. Rivera, P. Hagerman, D. Hessl, 2008, Brain Imaging and Behavior.

Amygdala dysfunction in men with the fragile X premutation.

S. Rivera, P. Hagerman, D. Hessl, 2007, Brain : a journal of neurology.

Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome

M. Ascano, T. Kornberg, P. Hagerman, 2016, Science Signaling.

ERP abnormalities elicited by word repetition in fragile X-associated tremor/ataxia syndrome (FXTAS) and amnestic MCI

C. DeCarli, M. Kutas, V. Iragui, 2014, Neuropsychologia.

Human Cerebral Cortex Proteome of Fragile X-Associated Tremor/Ataxia Syndrome

P. Hagerman, R. Hagerman, A. Herren, 2021, Frontiers in Molecular Biosciences.

Geometry of a branched DNA structure in solution.

P. Hagerman, J. Cooper, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Fragile X Premutation

P. Hagerman, F. Tassone, R. Hagerman, 2014, Journal of Neurodevelopmental Disorders.

A quantitative treatment of the kinetics of the folding transition of ribonuclease A.

R. L. Baldwin, P. Hagerman, 1976, Biochemistry.

Structures of branched DNA molecules in solution

P. Hagerman, J. Cooper, 1991 .

Protein and Mg(2+)-induced conformational changes in the S15 binding site of 16 S ribosomal RNA.

P. Hagerman, J. Williamson, J. W. Orr, 1998, Journal of molecular biology.

Global conformation of a self-cleaving hammerhead RNA.

P. Hagerman, K. M. Amiri, 1994, Biochemistry.

Fragile X Syndrome: Lessons Learned and What New Treatment Avenues Are on the Horizon.

P. Hagerman, R. Hagerman, 2021, Annual Review of Pharmacology and Toxicology.

Screening for the presence of FMR1 premutation alleles in women with parkinsonism.

P. Hagerman, R. Cilia, F. Tassone, 2009, Archives of neurology.

Neural progenitor cells from an adult patient with fragile X syndrome

P. Hagerman, F. Tassone, R. Hagerman, 2005, BMC Medical Genetics.

8 Fragile X syndrome

P. Hagerman, R. Hagerman, 2004 .

FMR1 gray‐zone alleles: Association with Parkinson's disease in women?

P. Hagerman, D. Hall, B. Ouyang, 2011, Movement disorders : official journal of the Movement Disorder Society.

Screening for expanded alleles of the FMR1 gene in blood spots from newborn males in a Spanish population.

P. Hagerman, F. Tassone, Ruiqin Pan, 2009, The Journal of molecular diagnostics : JMD.

Neuropathic features in fragile X premutation carriers

Lexin Li, C. Goetz, D. Nguyen, 2007, American journal of medical genetics. Part A.

Tremor and ataxia in fragile X premutation carriers: Blinded videotape study

J. Wuu, C. Goetz, P. Hagerman, 2003, Annals of neurology.

Initiation of translation of the FMR1 mRNA Occurs predominantly through 5'-end-dependent ribosomal scanning.

P. Hagerman, J. Hershey, Anna L. Ludwig, 2011, Journal of molecular biology.

Memantine for fragile X-associated tremor/ataxia syndrome: a randomized, double-blind, placebo-controlled trial.

D. Nguyen, Lin Zhang, P. Hagerman, 2014, The Journal of clinical psychiatry.

Treatment of fragile X-associated tremor ataxia syndrome (FXTAS) and related neurological problems

Lin Zhang, P. Hagerman, C. Bodine, 2008, Clinical interventions in aging.

A quantitative assessment of tremor and ataxia in FMR1 premutation carriers using CATSYS

D. Nguyen, P. Hagerman, F. Tassone, 2008, American journal of medical genetics. Part A.

Cerebellar Mild Iron Accumulation in a Subset of FMR1 Premutation Carriers with FXTAS

P. Hagerman, V. Martínez‐Cerdeño, A. Monterrubio, 2016, The Cerebellum.

A Majority of FXTAS Cases Present with Intranuclear Inclusions Within Purkinje Cells

P. Hagerman, V. Martínez‐Cerdeño, Adriana Reyes-Miranda, 2016, The Cerebellum.

Impairment of executive cognitive functioning in males with fragile X‐associated tremor/ataxia syndrome

D. Loesch, P. Hagerman, D. Hessl, 2007, Movement disorders : official journal of the Movement Disorder Society.

Two FMR1 premutation cases without nuclear inclusions

P. Hagerman, M. Lechpammer, R. Hagerman, 2017, Movement disorders : official journal of the Movement Disorder Society.

The Mitochondrial Genome of Acropora tenuis (Cnidaria; Scleractinia) Contains a Large Group I Intron and a Candidate Control Region

P. Hagerman, M. V. van Oppen, J. Catmull, 2002, Journal of Molecular Evolution.

Sequence-directed curvature of DNA

Paul J. Hagerman, P. Hagerman, 1986, Nature.

Global flexibility of tertiary structure in RNA: yeast tRNAPhe as a model system.

P. Hagerman, E. Vacano, M. Friederich, 1998, Proceedings of the National Academy of Sciences of the United States of America.

FMR1 premutation with Prader–Willi phenotype and fragile X‐associated tremor/ataxia syndrome

P. Hagerman, M. Lechpammer, R. Hagerman, 2017, Clinical case reports.

Influence of the fragile X mental retardation (FMR1) gene on the brain and working memory in men with normal FMR1 alleles

Andrea Schneider, Jun Yi Wang, David Hessl, 2013, NeuroImage.

FMR 1 premutation with Prader – Willi phenotype and fragile X-associated tremor / ataxia syndrome

P. Hagerman, M. Lechpammer, R. Hagerman, 2017 .

Fragile X Premutation

P. Hagerman, F. Tassone, R. Hagerman, 2014, Journal of Neurodevelopmental Disorders.

Neuropathological, clinical and molecular pathology in female fragile X premutation carriers with and without FXTAS

Michael R. Hunsaker, P. Hagerman, M. Hunsaker, 2012, Genes, brain, and behavior.

Volumetric brain changes in females with fragile X-associated tremor/ataxia syndrome (FXTAS)

S. Rivera, C. DeCarli, J. Brunberg, 2007, Neurology.

Outcomes in neurodevelopmental and genetic disorders: Fragile X syndrome

P. Hagerman, R. Hagerman, 2002 .

Refolding behavior of a kinetic intermediate observed in the low pH unfolding of ribonuclease A.

R. L. Baldwin, P. Hagerman, F. Schmid, 1979, Biochemistry.

Memantine Effects on Verbal Memory in Fragile X-associated Tremor/Ataxia Syndrome (FXTAS): a Double-Blind Brain Potential Study

P. Hagerman, J. Olichney, Jin-Chen Yang, 2014, Neuropsychopharmacology.

Functional status of men with the fragile X premutation, with and without the tremor/ataxia syndrome (FXTAS)

P. Hagerman, J. Grigsby, R. Hagerman, 2009, International journal of geriatric psychiatry.

Women with Fragile X–associated Tremor/Ataxia Syndrome

P. Hagerman, D. Hessl, A. Schneider, 2020, Movement disorders clinical practice.

Distribution of CGG repeat sizes within the fragile X mental retardation 1 (FMR1) homologue in a non-human primate population

P. Hagerman, D. Garcia Arocena, K. E. Breece, 2003, Human Genetics.

The fragile X premutation presenting as essential tremor.

A. Lang, A. Lozano, J. Brunberg, 2003, Archives of neurology.

Bulge-induced bends in RNA: quantification by transient electric birefringence.

P. Hagerman, M. Zacharias, 1995, Journal of molecular biology.

Autofluorescence-based analyses of intranuclear inclusions of Fragile X-associated tremor/ataxia syndrome.

P. Hagerman, Lisa Ma, 2020, BioTechniques.

List of contributors vii Preface ix 1 Attention deficit hyperactivity disorder 1

P. Hagerman, J. Beitchman, P. Howlin, 2002 .

Rare Intranuclear Inclusions in the Brains of 3 Older Adult Males With Fragile X Syndrome: Implications for the Spectrum of Fragile X-Associated Disorders

Michael R. Hunsaker, P. Hagerman, M. Hunsaker, 2011, Journal of neuropathology and experimental neurology.

Core flexibility of a truncated metazoan mitochondrial tRNA

P. Hagerman, A. Frazer-Abel, 2008, Nucleic acids research.

Determination of the angle between the acceptor and anticodon stems of a truncated mitochondrial tRNA.

P. Hagerman, A. A. Frazer-Abel, P J Hagerman, 1999, Journal of molecular biology.

Interhelix geometry of stems I and II of a self-cleaving hammerhead RNA.

P. Hagerman, F. Gast, K. M. Amiri, 1994, Biochemistry.

Dementia with mood symptoms in a fragile X premutation carrier with the fragile X-associated tremor/ataxia syndrome: clinical intervention with donepezil and venlafaxine.

J. Brunberg, Lin Zhang, P. Hagerman, 2006, The Journal of neuropsychiatry and clinical neurosciences.

Cognitive Impairment in a 65-year-old Male With the Fragile X-associated Tremor-Ataxia Syndrome (FXTAS)

J. Brunberg, P. Hagerman, S. Jacquemont, 2006 .

A Review of Fragile X Premutation Disorders

S. Rivera, P. Hagerman, D. Hessl, 2009 .

Fragile X-associated tremor/ataxia syndrome: an aging face of the fragile X gene.

P. Hagerman, R. Hagerman, Khaled M. A. Amiri, 2008, Archives of neurology.

The influence of symmetric internal loops on the flexibility of RNA.

P. Hagerman, P J Hagerman, M Zacharias, 1996, Journal of molecular biology.

A nomenclature of junctions and branchpoints in nucleic acids.

N. Seeman, D. Lilley, R. Clegg, 1995, Nucleic Acids Research.

The molecular biology of FXTAS

P. Hagerman, F. Tassone, 2010 .

Concomitant occurrence of FXTAS and clinically defined sporadic inclusion body myositis: report of two cases

Michael R. Hunsaker, P. Hagerman, J. Hewitt, 2017, Croatian medical journal.

Astroglial-targeted expression of the fragile X CGG repeat premutation in mice yields RAN translation, motor deficits and possible evidence for cell-to-cell propagation of FXTAS pathology

P. Hagerman, M. Hunsaker, R. Willemsen, 2019, Acta Neuropathologica Communications.

Hammering away at RNA global structure.

P. Hagerman, K. M. Amiri, 1996, Current opinion in structural biology.

Gene content and organization in a segment of the mitochondrial genome of the scleractinian coral Acropora tenuis: major differences in gene order within the anthozoan subclass zoantharia.

D. Miller, P. Hagerman, M. V. van Oppen, 1999, Molecular biology and evolution.

Phenotypes of hypofrontality in older female fragile X premutation carriers

P. Hagerman, J. Olichney, Jin-Chen Yang, 2013, Annals of neurology.

Neuropathological, clinical and molecular pathology in female fragile X premutation carriers with and without FXTAS

P. Hagerman, M. Hunsaker, S. Jacquemont, 2012 .

FMR1 premutation in females diagnosed with multiple sclerosis

J. Brunberg, P. Hagerman, F. Tassone, 2009, Journal of Neurology, Neurosurgery, and Psychiatry.

The global conformation of an active hammerhead RNA during the process of self-cleavage.

P. Hagerman, K. M. Amiri, 1996, Journal of molecular biology.

Erratum: The fragile X prevalence paradox (Journal of Medical Genetics (2008) vol. 45 (498-499))

P. Hagerman, 2008 .

Fragile X syndrome and connective tissue dysregulation

P. Hagerman, R. Hagerman, J. Ramírez-Cheyne, 2018, Clinical genetics.

Title Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome

M. Ascano, T. Kornberg, P. Hagerman, 2016 .

type receptor signaling mediates the abnormality fragile X syndrome.

M. Ascano, P. Hagerman, R. Hagerman, 2016 .

Treatment of fragile X-associated tremor ataxia syndrome (FXTAS) and related neurological problems

Lin Zhang, P. Hagerman, C. Bodine, 2008, Clinical Interventions in Aging.

Murine hippocampal neurons expressing Fmr1 gene premutations show early developmental deficits and late degeneration.

P. Hagerman, R. Willemsen, F. Tassone, 2010, Human molecular genetics.

Open-Label Sulforaphane Trial in FMR1 Premutation Carriers with Fragile-X-Associated Tremor and Ataxia Syndrome (FXTAS)

P. Hagerman, D. Kapogiannis, A. Schneider, 2023, Cells.

A quantitative ELISA assay for the fragile x mental retardation 1 protein.

D. Nguyen, P. Hagerman, F. Tassone, 2009, The Journal of molecular diagnostics : JMD.

Fragile X-associated tremor/ataxia syndrome.

P. Hagerman, M. Leehey, 2012, Handbook of clinical neurology.

Fragile X and autism: Intertwined at the molecular level leading to targeted treatments

P. Hagerman, R. Hagerman, G. Hoem, 2010, Molecular autism.

CGG-repeat length threshold for FMR1 RNA pathogenesis in a cellular model for FXTAS.

P. Hagerman, F. Tassone, Anna L. Ludwig, 2011, Human molecular genetics.

Fragile X–associated tremor/ataxia syndrome

P. Hagerman, R. Hagerman, 2015, Annals of the New York Academy of Sciences.

Evidence of mitochondrial dysfunction in fragile X-associated tremor/ataxia syndrome.

Sarah Wong, P. Hagerman, C. Giulivi, 2010, The Biochemical journal.

Functional status of men with the fragile X premutation, with and without the tremor/ataxia syndrome (FXTAS)

P. Hagerman, J. Grigsby, R. Hagerman, 2009, International journal of geriatric psychiatry.

Neural substrates of executive dysfunction in fragile X-associated tremor/ataxia syndrome (FXTAS): a brain potential study.

P. Hagerman, J. Olichney, Jin-Chen Yang, 2013, Cerebral cortex.

Clustered burst firing in FMR1 premutation hippocampal neurons: amelioration with allopregnanolone.

M. Rogawski, P. Hagerman, F. Tassone, 2012, Human molecular genetics.

Unmethylated Mosaic Full Mutation Males without Fragile X Syndrome

P. Hagerman, F. Tassone, R. Hagerman, 2024, Genes.

Variation of FMRP Expression in Peripheral Blood Mononuclear Cells from Individuals with Fragile X Syndrome

P. Hagerman, F. Tassone, R. Hagerman, 2024, Genes.

FMRP expression correlates with IQ in both PBMCs and fibroblasts from individuals with a FMR1 mutation

P. Hagerman, F. Tassone, R. Hagerman, 2024, The Journal of Molecular Diagnostics.

Outcomes in neurodevelopmental and genetic disorders: Fragile X syndrome

P. Hagerman, R. Hagerman, 2002 .