P. Skolnick

发表

Glutamate-based antidepressants: 20 years on.

P. Skolnick, P. Popik, R. Trullas, 2009, Trends in pharmacological sciences.

Glutamate and depression: clinical and preclinical studies.

P. Skolnick, I. Paul, Phil Skolnick, 2003, Annals of the New York Academy of Sciences.

Neurochemistry/Neuropharmacology

P. Skolnick, 2002 .

In situ molecular weight determination of brain and peripheral benzodiazepine binding sites.

S. Paul, P. Skolnick, E. Kempner, 1981, European journal of pharmacology.

Ro 5-4864: a potent benzodiazepine convulsant.

S. Paul, P. Skolnick, B. Weissman, 1983, European journal of pharmacology.

Endogenous inhibitors of 4'‐[3H]chlorodiazepam (Ro 5‐4864) binding to ‘peripheral’ sites for benzodiazepines

S. Paul, P. Skolnick, M. Goldman, 1984, FEBS letters.

Late evolutionary appearance of ‘peripheral-type’ binding sites for benzodiazepines

S. Paul, J. Barrett, P. Skolnick, 1985, Brain Research.

AHN 086: an irreversible ligand of "peripheral" benzodiazepine receptors.

P. Skolnick, A. Newman, K. Rice, 1986, Molecular pharmacology.

'Peripheral-type' benzodiazepine receptors in the kidney: regulation of radioligand binding by anions and DIDS.

P. Skolnick, H. Lueddens, 1987, European journal of pharmacology.

Glucostatic regulation of hypothalamic and brainstem [3H](+)-amphetamine binding during food deprivation and refeeding.

S. Paul, R. Hauger, P. Skolnick, 1986, European journal of pharmacology.

A benzodiazepine receptor antagonist decreases sleep and reverses the hypnotic actions of flurazepam.

S. Paul, W. Mendelson, P. Skolnick, 1983, Science.

Electrophysiological and pharmacological actions of the convulsant benzodiazepine Ro 5-4864.

S. Paul, P. Skolnick, B. Weissman, 1984, European journal of pharmacology.

Maximal electroshock increases the density of [3H]Ro 5-4864 binding to mouse cerebral cortex

P. Skolnick, A. Basile, B. Weissman, 1987, Brain Research Bulletin.

Pharmacological and neurochemical properties of 1,4-diazepines with two annelated heterocycles ('hetrazepines').

S. Paul, P. Skolnick, K. Weber, 1985, European journal of pharmacology.

Characterization of benzodiazepine receptors in the bovine pineal gland: evidence for the presence of an atypical binding site.

P. Skolnick, D. Klein, A. Basile, 1986, Brain research.

Subcellular Localization of “Peripheral‐Type” Binding Sites for Benzodiazepines in Rat Brain

P. Skolnick, A. Basile, Phil Skolnick, 1986, Journal of neurochemistry.

Sigma receptors modulate nicotinic receptor function in adrenal chromaffin cells

E. Rojas, P. Skolnick, H. Pollard, 1993, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

A physiological role of the benzodiazepine/GABA receptor-chloride ionophore complex in stress.

S. Paul, P. Skolnick, R. Trullas, 1987, Advances in experimental medicine and biology.

The agonist pharmacophore of the benzodiazepine receptor. Synthesis of a selective anticonvulsant/anxiolytic.

P. Skolnick, J. Cook, H. Diaz-Arauzo, 1991, Journal of medicinal chemistry.

Synthesis and evaluation of analogues of the partial agonist 6-(propyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (6-PBC) and the full agonist 6-(benzyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (Zk 93423) at wild type and recombinant GABAA receptors.

P. Skolnick, R. Mckernan, J. Cook, 1998, Journal of medicinal chemistry.

Ethanol inhibits mitogen-induced calcium mobilization in mouse splenocytes.

P. Skolnick, T. Mcintyre, Y. Sei, 1992, Life sciences.

Stress modulates calcium mobilization in immune cells.

P. Skolnick, T. Mcintyre, Y. Sei, 1991, Life sciences.

Inhibition of calcium mobilization is an early event in opiate‐induced immunosuppression

P. Skolnick, Y. Sei, E. Fride, 1991, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Be positive about negatives–recommendations for the publication of negative (or null) results

P. Skolnick, T. Steckler, A. Bespalov, 2019, European Neuropsychopharmacology.

Computer-aided molecular modeling, synthesis, and biological evaluation of 8-(benzyloxy)-2-phenylpyrazolo[4,3-c]quinoline as a novel benzodiazepine receptor agonist ligand.

T. Langer, P. Skolnick, R I Fryer, 1995, Journal of medicinal chemistry.

An in vitro binding assay which differentiates benzodiazepine 'agonists' and 'antagonists'.

S. Paul, P. Skolnick, M. Schweri, 1982, European journal of pharmacology.

Antagonism of the anxiolytic action of diazepam and chlordiazepoxide by the novel imidazopyridines, EMD 39593 and EMD 41717.

J. Crawley, P. Skolnick, A. Lippa, 1983, European journal of pharmacology.

Stable expression of type I gamma-aminobutyric acidA/benzodiazepine receptors in a transfected cell line.

P. Skolnick, G. Wong, Y. Sei, 1992, Molecular pharmacology.

Introduction: Biologics to Treat Substance Use Disorders: Vaccines, Monoclonal Antibodies, and Enzymes

P. Skolnick, 2016 .

Biologic Approaches to Treat Substance-Use Disorders.

P. Skolnick, 2015, Trends in pharmacological sciences.

100 years of ibogaine: neurochemical and pharmacological actions of a putative anti-addictive drug.

P. Skolnick, P. Popik, R. Layer, 1995, Pharmacological reviews.

Structurally modified ibogaine analogs exhibit differing affinities for NMDA receptors.

P. Skolnick, P. Popik, C. M. Bertha, 1996, European journal of pharmacology.

Elevated brain concentrations of 1,4-benzodiazepines in fulminant hepatic failure.

L. Pannell, P. Skolnick, R. Hughes, 1991, The New England journal of medicine.

GABAA Receptor Complex in an Experimental Model of Hepatic Encephalopathy: Evidence for Elevated Levels of an Endogenous Benzodiazepine Receptor Ligand

P. Skolnick, A. Basile, E. A. Jones, 1989, Journal of neurochemistry.

1-aminocyclopropanecarboxylates exhibit antidepressant and anxiolytic actions in animal models.

P. Skolnick, R. Trullas, K. Boje, 1991, European journal of pharmacology.

The benzodiazepine/GABA receptor complex in anxiety.

P. Skolnick, R. Trullas, H. Havoundjian, 1986, Clinical neuropharmacology.

Chlormethiazole: neurochemical actions at the γ-aminobutyric acid receptor complex

P. Skolnick, E. Moody, 1989 .

Chlormethiazole: neurochemical actions at the gamma-aminobutyric acid receptor complex.

P. Skolnick, E. Moody, 1989, European journal of pharmacology.

Coincidence of seizure susceptibility to caffeine and to the benzodiazepine inverse agonist, DMCM, in SWR and CBA inbred mice

P. Skolnick, O. Rennert, T. Seale, 1987, Pharmacology Biochemistry and Behavior.

[3H]GBR-12935: a specific high affinity ligand for labeling the dopamine transport complex.

S. Paul, A. Janowsky, P. Skolnick, 1985, European journal of pharmacology.

Hepatic encephalopathy, GABA-ergic neurotransmission and benzodiazepine receptor ligands.

P. Skolnick, A. Basile, E. Jones, 1990, Advances in experimental medicine and biology.

Preclinical Evaluation of the Abuse Potential of the Analgesic Bicifadine

P. Skolnick, K. Nicholson, A. Basile, 2009, Journal of Pharmacology and Experimental Therapeutics.

Ethanol stimulates gamma-aminobutyric acid receptor-mediated chloride transport in rat brain synaptoneurosomes.

S. Paul, P. Suzdak, R. D. Schwartz, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis and structure-activity relationships of 3,5-disubstituted 4,5-dihydro-6H-imidazo[1,5-a][1,4]benzodiazepin-6-ones at diazepam-sensitive and diazepam-insensitive benzodiazepine receptors.

P. Skolnick, S. Ananthan, S. Ealick, 1993, Journal of medicinal chemistry.

A Survey of Payer Perspectives on Cannabis Use Disorder

P. Skolnick, A. Duhig, Andrew M. Kiselica, 2018, Substance use & misuse.

Asymmetrical activation of GABA-gated chloride channels in cerebral cortex

P. Skolnick, R. Trullas, T. Mcintyre, 1988, Pharmacology Biochemistry and Behavior.

Beyond monoamine-based therapies: clues to new approaches.

P. Skolnick, 2002, The Journal of clinical psychiatry.

The flexible termini of conantokin G define its interactions with NMDA receptors

P. Skolnick, L. Otvos, G. Szendrei, 1997, Letters in Peptide Science.

The effects of surgical and chemical lesions on striatal [3H]threo-(+/-)-methylphenidate binding: correlation with [3H]dopamine uptake.

S. Paul, A. Janowsky, P. Skolnick, 1985, European journal of pharmacology.

[3H]Threo‐(±)‐Methylphenidate Binding to 3,4‐Dihydroxyphenylethylamine Uptake Sites in Corpus Striatum: Correlation with the Stimulant Properties of Ritalinic Acid Esters

S. Paul, A. Janowsky, P. Skolnick, 1985, Journal of neurochemistry.

[3H]GBR‐12935 Binding to the Dopamine Transporter Is Decreased in the Caudate Nucleus in Parkinson's Disease

J. Kleinman, S. Paul, A. Janowsky, 1987, Journal of neurochemistry.

Reduction in benzodiazepine receptors associated with Purkinje cell degeneration in ‘nervous’ mutant mice

S. Paul, P. Skolnick, P. Syapin, 1979, Nature.

Quinolinic acid protects rat cerebellar granule cells from glutamate-induced apoptosis

P. Skolnick, A. Basile, Y. Sei, 1998, Neuroscience Letters.

Quinolinic Acid Levels in a Murine Retrovirus‐Induced Immunodeficiency Syndrome

P. Skolnick, I. Paul, M. Heyes, 1996, Journal of neurochemistry.

Does high affinity [3H] imipramine binding label serotonin reuptake sites in brain and platelet?

S. Paul, P. Skolnick, K. Rice, 1981, Life sciences.

HIGH-AFFINITY BINDING SITES FOR TRICYCLIC ANTIDEPRESSANTS IN BRAIN AND PLATELETS

S. Paul, P. Skolnick, M. Rehavi, 1984 .

Demonstration of specific "high affinity" binding sites for [3H] imipramine on human platelets.

F. Goodwin, S. Paul, P. Skolnick, 1980, Life sciences.

Effects of the triple monoamine uptake inhibitor DOV 102,677 on alcohol-motivated responding and antidepressant activity in alcohol-preferring (P) rats.

P. Skolnick, J. Mamczarz, A. Basile, 2012, Alcoholism, clinical and experimental research.

FUNCTIONAL COMPARTMENTS OF ADENINE NUCLEOTIDES SERVING AS PRECURSORS OF ADENOSINE 3′,5′‐MONOPHOSPHATE IN MOUSE CEREBRAL CORTEX

P. Skolnick, J. W. Daly, J. W. Daly, 1975, Journal of neurochemistry.

N–Methyl–D–aspartate antagonists limit aminoglycoside antibiotic–induced hearing loss

C. Berlin, D. Webster, P. Skolnick, 1996, Nature Medicine.

Demonstration of brain-specific benzodiazepine receptors in rat retina

P. Skolnick, M. Zatz, S. Paul, 1980, Brain Research.

Glucostatic regulation of (+)-[3H]amphetamine binding in the hypothalamus: correlation with Na+,K+-ATPase activity.

S. Paul, R. Hauger, P. Skolnick, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Identification of inosine and hypoxanthine as endogenous inhibitors of [3H] diazepam binding in the central nervous system.

F. Goodwin, S. Paul, P. Skolnick, 1978, Life sciences.

Behavioral and electroencephalographic effects of the adenosine1 agonist, L-PIA

K. Berman, W. Mendelson, P. Skolnick, 1989, Pharmacology Biochemistry and Behavior.

Therapeutic doses of buspirone block D3 receptors in the living primate brain.

N. Volkow, J. Fowler, P. Skolnick, 2014, The international journal of neuropsychopharmacology.

The benzodiazepine--GABA--chloride ionophore receptor complex: common site of minor tranquilizer action.

S. Paul, P. Skolnick, P. Marangos, 1981, Biological psychiatry.

Repetitive stimulation of cyclic adenosine 3′,5′‐monophosphate formation by adrenergic agonists in incubated slices from rat cerebral cortex

P. Skolnick, J. Daly, J. Schultz, 1975, Journal of neurochemistry.

Novel interactions of cations with dihydropyridine calcium antagonist binding sites in brain

P. Skolnick, G. Bolger, Phil Skolnick, 1986, British journal of pharmacology.

Novel interactions ofcations withdihydropyridine calcium antagonist binding sites inbrain

P. Skolnick, 1986 .

Norepinephrine-Sensitive Adenylate Cyclases in Rat Brain: Relation to Behavior and Tyrosine Hydroxylase

P. Skolnick, J. Daly, Phil Skolnick, 1974, Science.

Pharmacological Properties of DOV 315,090, an ocinaplon metabolite

P. Skolnick, A. Basile, D. Farb, 2008, BMC pharmacology.

Differential immune responsiveness in mouse lines selectively bred for high and low sensitivity to ethanol

P. Skolnick, J. Petitto, B. Mcrae, 1990, Brain, Behavior, and Immunity.

CHARACTERIZATION OF BENZODIAZEPINE BINDING SITES IN CULTURED CELLS OF NEURAL ORIGIN

P. Skolnick, P. Syapin, 1979, Journal of neurochemistry.

Chronic administration of a partial agonist at strychnine-insensitive glycine receptors: a novel experimental approach to the treatment of ischemias.

P. Skolnick, L. Fossom, 1997, Journal of neural transmission. Supplementum.

Regulation of dihydropyridine calcium antagonist binding sites in the rat hippocampus following neurochemical lesions

S. Paul, A. Janowsky, P. Skolnick, 1987, Journal of neuroscience research.

Pharmacokinetic Properties and Human Use Characteristics of an FDA‐Approved Intranasal Naloxone Product for the Treatment of Opioid Overdose

P. Skolnick, Julie L Aker, Melissa Beck, 2016, Journal of clinical pharmacology.

Pentobarbital: dual actions to increase brain benzodiazepine receptor affinity.

S. Paul, P. Skolnick, J. Barker, 1981, Science.

Characterization of benzodiazepine receptors in primary cultures of fetal mouse brain and spinal cord neurons

S. Paul, J. Barker, P. Skolnick, 1980, Brain Research.

t‐[35S]Butylbicyclophosphorothionate Binding under Equilibrium and Nonequilibrium Conditions: Differential Effects of Barbiturates and γ‐Aminobutyric Acid in the Long‐Sleep and Short‐Sleep Selected Mouse Lines

P. Skolnick, T. Mcintyre, Phil Skolnick, 1991, Journal of neurochemistry.

Suppression of natural killer cell activity by FG 7142, a benzodiazepine receptor “inverse agonist”

P. Skolnick, J. Petitto, P. K. Arora, 1989, Brain, Behavior, and Immunity.

The Benzodiazepine—GABA Receptor Complex in Experimental Stress, Anxiety and Depression

S. Paul, J. Crawley, Abraham Weizman, 1988 .

Inescapable shock reduces [3H]Ro 5-4864 binding to “peripheral-type” benzodiazepine receptors in the rat

S. Paul, J. Crawley, P. Skolnick, 1986, Pharmacology Biochemistry and Behavior.

Volatile anesthetics bidirectionally and stereospecifically modulate ligand binding to GABA receptors.

P. Skolnick, A. Basile, B. Harris, 1994, European journal of pharmacology.

Neurochemical actions of inhalational anesthetics at the GABAA receptor complex.

P. Skolnick, G. Wong, B. Harris, 1993, The Journal of pharmacology and experimental therapeutics.

The permeability of gamma-aminobutyric acid-gated chloride channels is described by the binding of a "cage" convulsant, t-butylbicyclophosphoro[35S]thionate.

S. Paul, P. Skolnick, H. Havoundjian, 1986, Proceedings of the National Academy of Sciences of the United States of America.

β-CARBOLINES: SYNTHESIS AND NEUROCHEMICAL AND PHARMACOLOGICAL ACTIONS ON BRAIN BENZODIAZEPINE RECEPTORS

S. Paul, J. Crawley, P. Skolnick, 1983 .

Beta-carbolines: synthesis and neurochemical and pharmacological actions on brain benzodiazepine receptors.

S. Paul, J. Crawley, P. Skolnick, 1982, Journal of medicinal chemistry.

Strychnine-insensitive glycine receptors in embryonic chick retina: characteristics and modulation of NMDA neurotoxicity

P. Skolnick, G. Chader, K. Boje, 1992, Neurochemistry International.

1‐Aminocyclopropane Carboxylic Acid: A Potent and Selective Ligand for the Glycine Modulatory Site of the N‐Methyl‐d‐Aspartate Receptor Complex

P. Skolnick, A. Lewin, J. Marvizón, 1989, Journal of neurochemistry.

Polyamine-like actions of aminoglycosides at recombinant N-methyl-D-aspartate receptors.

P. Skolnick, S. C. Harvey, 1999, The Journal of pharmacology and experimental therapeutics.

“Peripheral‐Type”Binding Sites for Benzodiazepines in Brain: Relationship to the Convulsant Actions of Ro 5–4864

S. Paul, P. Skolnick, K. Weber, 1985, Journal of neurochemistry.

Regulation of “peripheral-type” binding sites for benzodiazepines in the pineal gland

P. Skolnick, D. Klein, B. Weissman, 1984, Pharmacology Biochemistry and Behavior.

Differential regulation of 'central' and 'peripheral' benzodiazepine binding sites in the rat olfactory bulb.

S. Paul, P. Skolnick, É. Mezey, 1984, European journal of pharmacology.

Depressed patients have decreased binding of tritiated imipramine to platelet serotonin "transporter".

F. Goodwin, S. Paul, J. Ballenger, 1981, Archives of general psychiatry.

Sustained exposure to a glycine receptor partial agonist differentially alters NMDA receptor agonist and antagonist potencies in cultured spinal cord neurons.

P. Skolnick, Y. Lin, L. Fossom, 1998, European journal of pharmacology.

Cannabinoid1 (CB-1) receptor antagonists: a molecular approach to treating acute cannabinoid overdose

P. Skolnick, R. Crystal, 2019, Journal of Neural Transmission.

On the front lines of the opioid epidemic: Rescue by naloxone.

P. Skolnick, 2018, European journal of pharmacology.

Benzodiazepine receptors in the central nervous system.

P. Skolnick, S. Paul, 1982, International review of neurobiology.

The antibacterial and NMDA receptor activating properties of aminoglycosides are dissociable.

P. Skolnick, H. Kirst, X. Li, 2000, European journal of pharmacology.

Modiﬁcation of cocaine self-administration by buspirone (buspar 1 ): potential involvement of D 3 and D 4 dopamine receptors

D. Sibley, N. Mello, P. Skolnick, 2012 .

Suppression of cytotoxic T lymphocyte (CTL) activity by FG 7142, a benzodiazepine receptor 'inverse agonist'.

P. Skolnick, E. E. Hanna, P. K. Arora, 1991, Immunopharmacology.

Ontogeny of susceptibility to the convulsant, Ro 5-4864, and its relationship to audiogenic seizure susceptibility in inbred mice.

T. Roderick, P. Skolnick, T. Seale, 1987, Life sciences.

Characterization of the Binding of [3H]Ro 5‐4864, a Convulsant Benzodiazepine, to Guinea Pig Brain

S. Paul, P. Skolnick, B. Weissman, 1984, Journal of Neurochemistry.

Rat pup isolation calls are reduced by functional antagonists of the NMDA receptor complex.

T. Insel, J. Winslow, P. Skolnick, 1990, European journal of pharmacology.

MK-801 is neuroprotective but does not improve survival in severe forebrain ischemia.

R. Lin, P. Skolnick, D. V. von Lubitz, 1993, European journal of pharmacology.

A novel treatment of global cerebral ischaemia with a glycine partial agonist.

R. Lin, P. Skolnick, D. V. von Lubitz, 1992, European journal of pharmacology.

Strain-dependent association between immune function and paw preference in mice

R. Collins, P. Skolnick, E. Fride, 1990, Brain Research.

The human "peripheral-type" benzodiazepine receptor: regional mapping of the gene and characterization of the receptor expressed from cDNA.

P. Skolnick, B. Emanuel, M. Budarf, 1992, DNA and cell biology.

NIH conference. The gamma-aminobutyric acid A (GABAA) receptor complex and hepatic encephalopathy. Some recent advances.

P. Skolnick, A. Basile, K. Mullen, 1989, Annals of internal medicine.

AMPA Receptors: A Target for Novel Antidepressants?

P. Skolnick, 2008, Biological Psychiatry.

The behavioral effects of the calcium agonist BAY K 8644 in the mouse: Antagonism by the calcium antagonist nifedipine

P. Skolnick, B. Weissman, G. Bolger, 1985, Naunyn-Schmiedeberg's Archives of Pharmacology.

Neurochemistry/Neuropharmacology

P. Skolnick, 2002 .

Characterization of high-affinity antidepressant binding to rat and human brain

S. Paul, P. Skolnick, M. Rehavi, 1983 .

High‐Affinity Binding of [3H]Desipramine to Rat Brain: A Presynaptic Marker for Noradrenergic Uptake Sites

S. Paul, P. Skolnick, M. Rehavi, 1982, Journal of neurochemistry.

'High affinity' binding of [3H]desipramine to rat cerebral cortex: relationship to tricyclic antidepressant-induced inhibition of norepinephrine uptake.

S. Paul, P. Skolnick, M. Rehavi, 1981, European journal of pharmacology.

Heterogeneity of β-adrenoreceptors in guinea pig alveolar type II cells

P. Skolnick, M. Sikpi, Salil K. Das, 1987 .

Stereoselective Actions of Volatile Anesthetics

P. Skolnick, E. Moody, 2000 .

2-[2-[4-[2-[2-[1,3-Dihydro-1,1-bis(4-hydroxyphenyl)-3-oxo-5-isobenzofuranthioureidyl]ethylaminocarbonyl]ethyl]phenyl] ethylamino]-5′-N-ethylcarboxamidoadenosine (FITC-APEC): A fluorescent ligand for A2a-adenosine receptors

K. Jacobson, P. Skolnick, R. Mccabe, 1992, Journal of Fluorescence.

Brain alpha-adrenergic receptors: comparison of [3H]WB 4101 binding with norepinephrine-stimulated cyclic AMP accumulation in rat cerebral cortex.

J. Davis, P. Skolnick, J. Daly, 1978, Brain research.

GABAA receptor modulators as anxioselective anxiolytics

P. Skolnick, A. Lippa, A. Basile, 2006 .

Re-energizing the Development of Pain Therapeutics in Light of the Opioid Epidemic

N. Volkow, P. Skolnick, 2016, Neuron.

Glycine site antagonists and partial agonists inhibit N-methyl-D-aspartate receptor-mediated [3H]arachidonic acid release in cerebellar granule cells.

P. Skolnick, A. Zapata, J. Capdevila, 1998, The Journal of pharmacology and experimental therapeutics.

Immune function in lines of mice selected for high or low degrees of behavioral asymmetry

R. Collins, P. Skolnick, E. Fride, 1990, Brain, Behavior, and Immunity.

Sustained exposure to 1-aminocyclopropanecarboxylic acid, a glycine partial agonist, alters N-methyl-D-aspartate receptor function and subunit composition.

P. Skolnick, A. Basile, L. Fossom, 1995, Molecular pharmacology.

Neuroprotective actions of 1-aminocyclopropanecarboxylic acid (ACPC): a partial agonist at strychnine-insensitive glycine sites.

R. Lin, P. Skolnick, D. V. von Lubitz, 1995, Neurological research.

1-Aminocyclopropanecarboxylic acid protects against dynorphin A-induced spinal injury.

P. Skolnick, J. Long, 1994, European journal of pharmacology.

Direct and allosteric control of glutamate receptors

P. Skolnick, I. Reynolds, M. Palfreyman, 1994 .

High-performance liquid chromatographic assay for 1-aminocyclopropanecarboxylic acid from plasma and brain.

P. Skolnick, K. Boje, R. Miller, 1992, Journal of chromatography.

Blockade of N-methyl-D-aspartate induced convulsions by 1-aminocyclopropanecarboxylates.

P. Skolnick, K. Rice, A. Lewin, 1989, Life sciences.

Effect of NMDAR antagonists in the tetrabenazine test for antidepressants: comparison with the tail suspension test

P. Skolnick, P. Popik, J. Czekaj, 2015, Acta Neuropsychiatrica.

Characterization of the effects of AHN 086, an irreversible ligand of "peripheral" benzodiazepine receptors, on contraction in guinea-pig atrial and ileal longitudinal smooth muscle.

P. Skolnick, A. Newman, K. Rice, 1989, Canadian journal of physiology and pharmacology.

Characterization of stress-induced alterations in [3H] Ro5-4864 binding to peripheral benzodiazepine receptors in rat heart and kidney

S. Paul, J. Crawley, P. Skolnick, 1988, Pharmacology Biochemistry and Behavior.

Purification and characterization of an endogenous protein modulator of radioligand binding to "peripheral-type" benzodiazepine receptors and dihydropyridine Ca2+-channel antagonist binding sites.

S. Paul, P. Skolnick, B. Martin, 1988, Biochemical pharmacology.

'Brain-specific' benzodiazepine receptors are localized in the inner plexiform layer of rat retina.

S. Paul, P. Skolnick, R. Eskay, 1980, European journal of pharmacology.

Modulation of the Benzodiazepine/γ‐Aminobutyric Acid Receptor Chloride Channel Complex by Inhalation Anesthetics

P. Suzdak, P. Skolnick, S. Paul, 1988, Journal of neurochemistry.

Sedative and electroencephalographic actions of erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA): Relationship to inhibition of brain adenosine deaminase

S. Paul, W. Mendelson, P. Skolnick, 2004, Psychopharmacology.

Amelioration of hepatic encephalopathy by pharmacologic antagonism of the GABAA-benzodiazepine receptor complex in a rabbit model of fulminant hepatic failure.

P. Skolnick, K. Mullen, E. Jones, 1987, Gastroenterology.

Treatment of overdose in the synthetic opioid era.

P. Skolnick, 2021, Pharmacology & therapeutics.

Pharmacokinetic and pharmacodynamic factors contributing to the convulsant action of β-carboline-3-carboxylic acid esters

S. Paul, J. Barrett, W. Mendelson, 1983 .

3-carboethoxy-β-carboline (β-CCE) elicits electroencephalographic seizures in rats: Reversal by the benzodiazepine antagonist CGS 8216

S. Paul, W. Mendelson, P. Skolnick, 1983 .

Blockade of 3-carbomethoxy-β-carboline induced seizures by diazepam and the benzodiazepine antagonists, Ro 15-1788 and CGS 8216

S. Paul, P. Skolnick, M. Cain, 1982, Pharmacology, Biochemistry and Behavior.

Stereospecific displacement of [3H]phencyclidine (PCP) receptor binding by an enantiomeric pair of PCP analogs.

C. Pert, P. Skolnick, R. Quirion, 1981, European journal of pharmacology.

The pathogenesis and treatment of hepatic encephalopathy: evidence for the involvement of benzodiazepine receptor ligands.

P. Skolnick, A. Basile, E. Jones, 1991, Pharmacological reviews.

Brain concentrations of benzodiazepines are elevated in an animal model of hepatic encephalopathy.

L. Pannell, P. Skolnick, H. Fales, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Hepatic Encephalopathy and Benzodiazepine Receptor Ligands

P. Skolnick, A. Basile, K. Mullen, 1989 .

International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function.

E A Barnard, G. Biggio, R. Olsen, 1998, Pharmacological reviews.

Selective anxiolysis produced by ocinaplon, a GABA(A) receptor modulator.

P. Czobor, P. Skolnick, B. Beer, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis and pharmacological properties of novel 8-substituted imidazobenzodiazepines: high-affinity, selective probes for alpha 5-containing GABAA receptors.

P. Skolnick, J. Cook, R. Liu, 1996, Journal of medicinal chemistry.

Labelling of diazepam-sensitive and -insensitive benzodiazepine receptors with [3H]tert-butyl-8-chloro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo [1,5-a][1,4]benzodiazepine 3-carboxylate (ZG-63).

P. Skolnick, B. de Costa, G. Wong, 1993, European Journal of Pharmacology.

Heterogeneity of Benzodiazepine Receptors in the Central Nervous System Demonstrated with Kenazepine, an Alkylating Benzodiazepine

S. Paul, P. Skolnick, K. Rice, 1980, Journal of neurochemistry.

Stimulation of adenosine 3',5'-monophosphate formation in rat cerebral cortical slices by methoxamine: interaction with an alpha adrenergic receptor.

P. Skolnick, J. Daly, 1975, The Journal of pharmacology and experimental therapeutics.

Differential seizure sensitivities to picrotoxinin in two inbred strains of mice (DBA/2J and BALB/c ByJ): parallel changes in GABA receptor-mediated chloride flux and receptor binding

S. Paul, R. D. Schwartz, P. Skolnick, 1989, Brain Research.

BENZODIAZEPIRE RECEPTOR LIGANDS

P. Skolnick, A. Basile, K. Mullen, 1989 .

Morphine-induced immune alterations in vivo.

P. Skolnick, K. Waggie, J. Petitto, 1990, Cellular immunology.

LY503430, a Novel α-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid Receptor Potentiator with Functional, Neuroprotective and Neurotrophic Effects in Rodent Models of Parkinson's Disease

E. Nisenbaum, K. Whalley, P. Skolnick, 2003, Journal of Pharmacology and Experimental Therapeutics.

[3H]N-2-(4-(N-benzamido)phenyl)propyl-2-propanesulfonamide: a novel AMPA receptor potentiator and radioligand.

P. Skolnick, P. Ornstein, D. Bleakman, 2001, Journal of medicinal chemistry.

Synthesis of 6-substituted beta-carbolines that behave as benzodiazepine receptor antagonists or inverse agonists.

P. Skolnick, J. Cook, T. Hagen, 1987, Journal of medicinal chemistry.

Receptors for the age of anxiety: pharmacology of the benzodiazepines.

S. Paul, P. Skolnick, J. Tallman, 1980, Science.

A rapid and sensitive radioreceptor assay for benzodiazepine in plasma.

F. Goodwin, S. Paul, P. Skolnick, 1979, Archives of general psychiatry.

Chronic antidepressant treatments increase cytochrome b mRNA levels in mouse cerebral cortex

P. Skolnick, R. Layer, M. Strakhova, 1997, Journal of Molecular Neuroscience.

Electroconvulsive shock increases endogenous monoamine oxidase inhibitor activity in brain and cerebrospinal fluid

S. Paul, P. Skolnick, J. Bacher, 1986, Neuroscience Letters.

Anxioselective anxiolytics: on a quest for the Holy Grail.

P. Skolnick, 2012, Trends in pharmacological sciences.

[3H]glycine binding is modulated by Mg2+ and other ligands of the NMDA receptor-cation channel complex.

P. Skolnick, J. Marvizón, 1988, European journal of pharmacology.

Convulsant potencies of tetrazoles are highly correlated with actions on GABA/benzodiazepine/picrotoxin receptor complexes in brain.

S. Paul, J. Crawley, P. Skolnick, 1984, Life Science.

Correlation between benzodiazepine receptor occupation and anticonvulsant effects of diazepam

S. Paul, P. Skolnick, P. Syapin, 1979, Nature.

Rapid changes in brain benzodiazepine receptors after experimental seizures.

S. Paul, P. Skolnick, 1978, Science.

Chapter 3. Benzodiazepine Receptors

S. Paul, P. Skolnick, 1981 .

Effects of tetrazole derivatives on [3H]diazepam binding in vitro: correlation with convulsant potency.

S. Paul, P. Skolnick, M. Rehavi, 1982, European journal of pharmacology.

Desensitization of the NMDA receptor complex by glycinergic ligands in cerebellar granule cell cultures

P. Skolnick, K. Boje, G. Wong, 1993, Brain Research.

Is Receptor Heterogeneity Relevant to the Anxiolytic Actions of Benzodiazepine Receptor Ligands

P. Skolnick, 1991 .

Differential responsiveness of cerebellar Purkinje neurons to GABA and benzodiazepine receptor ligands in an animal model of hepatic encephalopathy

P. Skolnick, A. Basile, K. Mullen, 1988, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Is the benzodiazepine/GABA receptor chloride ionophore complex involved in physical and emotional stress?

P. Skolnick, H. Havoundjian, R. Trullás, 1988, Advances in experimental medicine and biology.

Modulation of the benzodiazepine-GABA receptor chloride ionophore complex by multiple allosteric sites: evidence for a barbiturate "receptor".

S. Paul, P. Skolnick, H. Havoundjian, 1987, Psychopharmacology series.

Rapid, stress-induced modification of the benzodiazepine receptor-coupled chloride ionophore

S. Paul, P. Skolnick, H. Havoundjian, 1986, Brain Research.

Inhibition of γ-aminobutyric acid stimulated [3H]diazepam binding by benzodiazepine receptor ligands

S. Paul, P. Skolnick, P. Marangos, 1981 .

The mechanism(s) of action of the benzodiazepines

P. Skolnick, S. Paul, 1981, Medicinal research reviews.

Increased benzodiazepine receptor number elicited in vitro by a novel purine, EMD 28422.

S. Paul, P. Skolnick, P. Marangos, 1980, European journal of pharmacology.

Labelling of benzodiazepine receptors in vivo

S. Paul, P. Skolnick, M. J. Williamson, 1978, Nature.

High affinity ligands for 'diazepam-insensitive' benzodiazepine receptors.

P. Skolnick, G. Wong, G Wong, 1992, European journal of pharmacology.

Alkyl-substituted γ-butyrolactones inhibit [35S]TBPS binding to a GABA linked chloride ionophore

P. Skolnick, K. Rice, B. Weissman, 1984 .

Synthesis of novel 2-phenyl-2H-pyrazolo[4,3-c]isoquinolin-3-ols: topological comparisons with analogues of 2-phenyl-2,5-dihydropyrazolo[4,3-c]quinolin-3(3H)-ones at benzodiazepine receptors.

P. Skolnick, J. Cook, M. Allen, 1992, Journal of Medicinal Chemistry.

Regulation of γ‐Aminobutyric Acid/Barbiturate Receptor‐Gated Chloride Ion Flux in Brain Vesicles by Phospholipase A2: Possible Role of Oxygen Radicals

S. Paul, R. D. Schwartz, P. Skolnick, 1988, Journal of neurochemistry.

Differential Sensitivity of “Central” and “Peripheral” Type Benzodiazepine Receptors to Phospholipase A2

S. Paul, P. Skolnick, R. Cohen, 1986, Journal of neurochemistry.

Demonstration of GABA/barbiturate-receptor-mediated chloride transport in rat brain synaptoneurosomes: a functional assay of GABA receptor-effector coupling.

S. Paul, R. D. Schwartz, P. Skolnick, 1986, Advances in biochemical psychopharmacology.

Structure-activity relationship studies at the benzodiazepine receptor (BZR): a comparison of the substitutent effects of pyrazoloquinolinone analogs.

P. Skolnick, A. Basile, R I Fryer, 1993, Journal of medicinal chemistry.

Syntheses of 5-thienyl and 5-furyl-substituted benzodiazepines: probes of the pharmacophore for benzodiazepine receptor agonists

P. Skolnick, Weijiang Zhang, K. Koehler, 1995 .

Synthesis of benzo-fused benzodiazepines employed as probes of the agonist pharmacophore of benzodiazepine receptors.

P. Skolnick, K. Koehler, J. Cook, 1994, Journal of medicinal chemistry.

Molecular features associated with polyamine modulation of NMDA receptors.

P. Skolnick, P. Popik, H. Navarro, 1998, Journal of medicinal chemistry.

Antidepressant-like actions of DOV 21,947: a "triple" reuptake inhibitor.

A. Janowsky, P. Skolnick, P. Popik, 2003, European journal of pharmacology.

Structural requirements for agonist actions at the benzodiazepine receptor: studies with analogues of 6-(benzyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester.

P. Skolnick, P Skolnick, J M Cook, 1990, Journal of medicinal chemistry.

Biomimetic approach to potential benzodiazepine receptor agonists and antagonists.

S. Paul, P. Skolnick, M. Cain, 1984, Journal of medicinal chemistry.

Catecholamine receptors and cyclic AMP formation in the central nervous system: effects of tetrahydroisoquinoline derivatives.

P. Skolnick, Y. Nimitkitpaisan, 1978, Life sciences.

Altered brain fyn kinase in a murine acquired immunodeficiency syndrome

P. Skolnick, I. Paul, L. Whitesell, 1996, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

GABA receptor-mediated chloride transport in a "cell-free" membrane preparation from brain.

S. Paul, R. D. Schwartz, P. Skolnick, 1986, Science.

Barbiturate and picrotoxin‐sensitive chloride efflux in rat cerebral cortical synaptoneurosomes

S. Paul, R. D. Schwartz, P. Skolnick, 1984, FEBS letters.

Adenosine and Cyclic AMP in Rat Cerebral Cortical Slices: Effects of Adenosine Uptake Inhibitors and Adenosine Deaminase Inhibitors

P. Skolnick, J. Daly, J. W. Daly, 1981, Journal of neurochemistry.

Stimulation of adenosine 3',5'-monophosphate formation by alpha and beta adrenergic agonists in rat cerebral cortical slices: effects of clonidine.

P. Skolnick, J. Daly, 1975, Molecular pharmacology.

Antidepressants : new pharmacological strategies

P. Skolnick, 1997 .

Adaptation of N-methyl-D-aspartate (NMDA) receptors following antidepressant treatment: implications for the pharmacotherapy of depression.

P. Skolnick, P. Popik, G. Nowak, 1996, Pharmacopsychiatry.

The potential for safer anaesthesia using stereoselective anaesthetics.

P. Skolnick, B. Harris, E. Moody, 1994, Trends in pharmacological sciences.

Pharmacokinetic Interaction between Naloxone and Naltrexone Following Intranasal Administration to Healthy Subjects

P. Skolnick, C. N. Chiang, Rebekah Snyder, 2019, Drug Metabolism and Disposition.

Inhibition of brain adenosine deaminase by 2′‐deoxycoformy cin and erythro‐9‐(2‐hydroxy‐3‐nonyl) adenine

P. Skolnick, J. Daly, Y. Nimitkitpaisan, 1978, Journal of neurochemistry.

Alcohols stimulate γ-aminobutyric acid receptor-mediated chloride uptake in brain vesicles: correlation with intoxication potency

S. Paul, P. Suzdak, R. D. Schwartz, 1988, Brain Research.

A selective imidazobenzodiazepine antagonist of ethanol in the rat.

Glowa, S. Paul, J. Crawley, 1986, Science.

Characterization of barbiturate-stimulated chloride efflux from rat brain synaptoneurosomes

S. Paul, R. D. Schwartz, P. Skolnick, 1985, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Acute stress enhances the activity of the GABA receptor-gated chloride ion channel in brain

S. Paul, R. D. Schwartz, P. Skolnick, 1987, Brain Research.

Antagonism of α- and β-adrenergic-mediated accumulations of cyclic AMP in rat cerebral cortical slices by the β-antagonist (−)alprenolol

P. Skolnick, J. Daly, 1976 .

Purinergic inhibition of diazepam binding to rat brain (in vitro).

F K Goodwin, F. Goodwin, S. Paul, 1979, Life sciences.

Synthesis and evaluation of imidazo[1,5-a][1,4]benzodiazepine esters with high affinities and selectivities at "diazepam-insensitive" benzodiazepine receptors.

P. Skolnick, C. Dominguez, K. Rice, 1993, Journal of medicinal chemistry.

Chapter 3 - Pharmacology of Ibogaine and Ibogaine-Related Alkaloids

P. Skolnick, P. Popik, 1999 .

Stereoselective inhibition of natural killer activity by the sigma ligand (+)-pentazocine

P. Skolnick, R. Maity, R. Mukherjee, 1996, Journal of Neuroimmunology.

Functional antagonists at the NMDA receptor complex exhibit antidepressant actions.

P. Skolnick, R. Trullás, 1990, European journal of pharmacology.

Tissue specific regulation of "peripheral-type" benzodiazepine receptor density after chemical sympathectomy.

P. Skolnick, A. Basile, 1988, Life sciences.

Avermectin B1a: an irreversible activator of the gamma-aminobutyric acid-benzodiazepine-chloride-ionophore receptor complex.

S. Paul, P. Skolnick, M. Zatz, 1980, Biochemical and biophysical research communications.

Differences in fear motivated behaviors among inbred mouse strains

P. Skolnick, Phil Skolnick, Ramon Trullas, 2005, Psychopharmacology.

Neurochemical and behavioral effects of clonidine and related imidazolines: interaction with alpha-adrenoceptors.

D. Segal, P. Skolnick, J. Daly, 1978, European Journal of Pharmacology.

Catechol oestrogens inhibit oestrogen elicited accumulation of hypothalamic cyclic AMP suggesting role as endogenous anti-oestrogens

S. Paul, P. Skolnick, 1977, Nature.

Inhibition of diazepam binding by tryptophan derivatives including melatonin and its brain metabolite N-acetyl-5-methoxy kynurenamine.

F. Goodwin, S. Paul, P. Skolnick, 1981, Life sciences.

The Opioid Epidemic: Crisis and Solutions.

P. Skolnick, Phil Skolnick, 2018, Annual review of pharmacology and toxicology.

Accumulation of adenosine 3′,5′‐monophosphate in incubated slices from discrete regions of squirrel monkey cerebral cortex: effect of norepinephrine, serotonin and adenosine

P. Skolnick, B. Hoffer, J. Daly, 1973, Journal of neurochemistry.

Solubilization and partial purification of the high affinity [3H] imipramine binding site from human platelets

S. Paul, P. Skolnick, M. Rehavi, 1982, FEBS letters.

(+)-Amphetamine binding to rat hypothalamus: relation to anorexic potency for phenylethylamines.

S. Paul, P. Skolnick, B. Hulihan-Giblin, 1982, Science.

Benzodiazepines are weak inhibitors of [3H]nitrobenzylthioinosine binding to adenosine uptake sites in brain

S. Paul, P. Skolnick, J. Patel, 1982, Neuroscience Letters.

Drugs acting at the strychnine-insensitive glycine receptor do not induce HSP-70 protein in the cingulate cortex

F. Sharp, P. Skolnick, Phil Skolnick, 1994, Neuroscience Letters.

Binding of alpha-and beta-adrenergic ligands to cerebral cortical membranes: effect of 6-hydroxydopamine treatment and relationship to the responsiveness of cyclic amp-generating systems in two rat strains.

J. Davis, P. Skolnick, J. Daly, 1978, European journal of pharmacology.

Reversal of the behavioral and electrophysiological abnormalities of an animal model of hepatic encephalopathy by benzodiazepine receptor ligands

P. Skolnick, A. Basile, S. H. Gammal, 1990, Hepatology.

[3H] IMIPRAMINE BINDING TO THE SEROTONIN “TRANSPORTER” IN HUMAN BRAIN AND PLATELET: A POSSIBLE BIOLOGICAL MARKER IN DEPRESSION

S. Paul, P. Skolnick, M. Rehavi, 1982 .

Demonstration of specific high affinity binding sites for [3H] imipramine in human brain.

F. Goodwin, S. Paul, P. Skolnick, 1980, Life sciences.

Pentobarbital potentiates GABA-enhanced [3H]-diazepam binding to benzodiazepine receptors.

S. Paul, P. Skolnick, J. Barker, 1980, European journal of pharmacology.

Glutamate and Depression

P. Skolnick, I. Paul, Phil Skolnick, 2003 .

Stereospecific actions of the inhalation anesthetic isoflurane at the GABAA receptor complex

P. Skolnick, Phil Skolnick, Eric J. Moody, 1993, Brain Research.

Isoflurane anesthesia is stereoselective.

P. Skolnick, B. Harris, E. Moody, 1992, European journal of pharmacology.

Stereospecific reversal of nitrous oxide analgesia by naloxone.

P. Skolnick, A. Newman, K. Rice, 1989, Life sciences.

Is an Adaptation of NMDA Receptors an Obligatory Step in Antidepressant Action

P. Skolnick, R. Layer, N. Huang, 1997 .

The putative anti-addictive drug ibogaine is a competitive inhibitor of [3H]MK-801 binding to the NMDA receptor complex

P. Skolnick, P. Popik, R. Layer, 1994, Psychopharmacology.

Interaction between purine and benzodiazepine: Inosine reverses diazepam-induced stimulation of mouse exploratory behavior.

F K Goodwin, F. Goodwin, S. Paul, 1981, Science.

GlycineB Receptor Antagonists and Partial Agonists Prevent Memory Deficits in Inhibitory Avoidance Learning

P. Skolnick, A. Zapata, J. Capdevila, 2000, Neurobiology of Learning and Memory.

Diethylstilbestrol-elicited accumulation of cyclic AMP in incubated rat hypothalamus.

P. Skolnick, J. Daly, B. Weissman, 1975, Endocrinology.

Stimulation of Adenosine 3',5'-monophosphate formation in incubated rat hypothalamus by estrogenic compounds: relationship to biologic potency and blockade by anti-estrogens.

P. Skolnick, B. Weissman, 1975, Neuroendocrinology.

LY 503430 , a novel AMPA receptor potentiator with functional , neuroprotective and neurotrophic effects in rodent models of Parkinson ’ s disease

E. Nisenbaum, K. Whalley, P. Skolnick, 2003 .

LY 503430 , a Novel-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid Receptor Potentiator with Functional , Neuroprotective and Neurotrophic Effects in Rodent Models of Parkinson ’ s Disease

E. Nisenbaum, K. Whalley, P. Skolnick, 2003 .

Estrogen-induced efflux of endogenous catecholamines from the hypothalamus in vitro

P. Skolnick, J. Axelrod, J. Saavedra, 1979, Brain Research.

Electrophysiological actions of Ro5-4864 on cerebellar Purkinje neurons: evidence for "peripheral" benzodiazepine receptor-mediated depression.

P. Skolnick, A. Basile, G. Bolger, 1989, Journal of Pharmacology and Experimental Therapeutics.

Medication discovery for addiction: translating the dopamine D3 receptor hypothesis.

D. Sibley, M. Nader, P. Skolnick, 2012, Biochemical pharmacology.

Inosine, an endogenous ligand of the brain benzodiazepine receptor, antagonizes pentylenetetrazole-evoked seizures.

S. Paul, P. Skolnick, P. Marangos, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Inosine may be an endogenous ligand for benzodiazepine receptors on cultured spinal neurons.

S. Paul, J. Macdonald, P. Skolnick, 1979, Science.

Site-specific acylation of GABA-gated Cl- channels: effects on 36Cl- uptake.

P. Skolnick, K. Rice, B. de Costa, 1991, European journal of pharmacology.

Enhancement of t‐[35S]Butylbicyclophosphorothionate and [3H]Strychnine Binding by Monovalent Anions Reveals Similarities Between γ‐Aminobutyric Acid‐ and Glycine‐Gated Chloride Channels

P. Skolnick, J. Marvizón, Juan Carlos G. Marvizón, 1988, Journal of neurochemistry.

Countermeasures for Preventing and Treating Opioid Overdose

E. Snyder, P. Skolnick, E. Lau, 2020, Clinical pharmacology and therapeutics.

Interaction of barbiturates with benzodiazepine receptors in the central nervous system

S. Paul, P. Skolnick, J. Barker, 1982, Brain Research.

The GABAA Receptor Complex: Is it a Locus of Action for Inhalation Anesthetics?

P. Skolnick, H. Yeh, E. Moody, 1991 .

Halothane and anaesthesia

P. Skolnick, H. Yeh, E. Moody, 1990, Nature.

Effects of calcium antagonists on phencyclidine behaviors

S. Paul, J. Crawley, P. Skolnick, 1986, Pharmacology Biochemistry and Behavior.

Acylating phencyclidines irreversibly enhance brain calcium antagonist binding

P. Skolnick, K. Rice, B. Weissman, 1986, Pharmacology Biochemistry and Behavior.

Enhancement of brain calcium antagonist binding by phencyclidine and related compounds

P. Skolnick, G. Bolger, M. Rafferty, 1986, Pharmacology Biochemistry and Behavior.

Anion regulation of [3H]strychnine binding to glycine-gated chloride channels is explained by the presence of two anion binding sites.

P. Skolnick, J. Marvizón, 1988, Molecular pharmacology.

Different subunit requirements for volatile and nonvolatile anesthetics at gamma-aminobutyric acid type A receptors.

P. Skolnick, G. Wong, B. Harris, 1995, Molecular pharmacology.

Response: is ethanol antagonist rol5-4513 selective for ethanol?

S. Paul, J. Crawley, P. Suzdak, 1988, Science.

Dizocilpine attenuates streptomycin-induced vestibulotoxicity in rats

Alan M. Brichta, P. Skolnick, A. Brichta, 1999, Neuroscience Letters.

Aminoglycoside neurotoxicity involves NMDA receptor activation

P. Skolnick, J. Segal, A. Basile, 1999, Brain Research.

Polyamine-like actions of aminoglycosides and aminoglycoside derivatives at NMDA receptors.

P. Skolnick, J. Segal, 1998, European journal of pharmacology.

The development of glutamate-based antidepressants is taking longer than expected.

P. Skolnick, Yong-Ku Kim, I. Cavero, 2018, Drug discovery today.

Antidepressants for the new millennium.

P. Skolnick, Phil Skolnick, 1999, European journal of pharmacology.

Modulation of neurotransmitter metabolism by dihydropyridine calcium channel ligands in mouse brain

P. Skolnick, A. Basile, G. Bolger, 1988, Brain Research.

Local anesthetics differentiate dihydropyridine calcium antagonist binding sites in rat brain and cardiac membranes.

P. Skolnick, J. Daly, G. Bolger, 1987, Journal of Pharmacology and Experimental Therapeutics.

Irazepine, a noncompetitive, irreversible inhibitor of 3H-diazepam binding to benzodiazepine receptors

S. Paul, A. Brossi, P. Skolnick, 1979, Nature.

Nifedipine blocks sleep induction by flurazepam in the rat.

W. Mendelson, P. Skolnick, J. V. Martin, 1984, Sleep.

Amitifadine, a triple monoamine uptake inhibitor, reduces binge drinking and negative affect in an animal model of co-occurring alcoholism and depression symptomatology

P. Skolnick, A. Basile, H. June, 2012, Pharmacology Biochemistry and Behavior.

The Reinforcing Properties of Alcohol are Mediated by GABAA1 Receptors in the Ventral Pallidum

P. Skolnick, Chunrong Ma, William J. A. Eiler, 2003, Neuropsychopharmacology.

Measures of outcome for stimulant trials: ACTTION recommendations and research agenda.

Brian D. Kiluk, M. Detke, R. Dworkin, 2016, Drug and alcohol dependence.

Triple reuptake inhibitors ("broad spectrum" antidepressants).

P. Skolnick, A. Basile, 2007, CNS & neurological disorders drug targets.

Triple reuptake inhibitors as antidepressants

P. Skolnick, A. Basile, 2006 .

Dopamine and Depression

P. Skolnick, 2005 .

Spatial learning impairment in a murine model of AIDS

P. Skolnick, I. Paul, Y. Sei, 1992, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Behavioral studies with anxiolytic drugs. IV. Serotonergic involvement in the effects of buspirone on punished behavior of pigeons.

J. Barrett, P. Skolnick, J. Witkin, 1987, The Journal of pharmacology and experimental therapeutics.

Outcome Measures in Medication Trials for Substance Use Disorders

P. Skolnick, D. McCann, Tatiana Ramey, 2015, Current Treatment Options in Psychiatry.

Genetic differences in a tail suspension test for evaluating antidepressant activity

P. Skolnick, R. Trullás, B. Jackson, 2004, Psychopharmacology.

Mammalian alkaloids. 8. Synthesis and biological effects of tetrahydropapaveroline related 1-benzyltetrahydroisoquinolines.

A. Brossi, P. Skolnick, J. Daly, 1980, Journal of medicinal chemistry.

Strain differences in responsiveness of norepinephrine-sensitive adenosine 3',5'-monophosphate-generating systems in rat brain slices after intraventricular administration of 6-hydroxydopamine.

P. Skolnick, J. Daly, 1977, European journal of pharmacology.

Are the toxicities of pentobarbital and ethanol mediated by the GABA-benzodiazepine receptor-chloride ionophore complex?

W. Mendelson, P. Skolnick, B. Weissman, 1985, European journal of pharmacology.

Comparative neuropharmacology of antianxiety drugs

S. Paul, P. Skolnick, 1982, Pharmacology, Biochemistry and Behavior.

Behavioral studies with anxiolytic drugs. III. Antipunishment actions of buspirone in the pigeon do not involve benzodiazepine receptor mechanisms.

J. Barrett, P. Skolnick, J. Witkin, 1986, The Journal of pharmacology and experimental therapeutics.

Modification of cocaine self-administration by buspirone (buspar®): potential involvement of D3 and D4 dopamine receptors.

D. Sibley, N. Mello, P. Skolnick, 2013, The international journal of neuropsychopharmacology.

Behavioral and neurochemical studies on the anticonflict actions of buspirone

S. Paul, J. Barrett, W. Mendelson, 1984 .

Synthesis of [123I]tert-butyl 8-iodo-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine 3-carboxylate, a potential SPECT imaging agent for diazepam-insensitive (DI) benzodiazepine receptors

K. Lee, P. Skolnick, K. Rice, 1994 .

Antidepressant-like actions of the polyamine site NMDA antagonist, eliprodil (SL-82.0715)

P. Skolnick, P. Popik, R. Layer, 1995, Pharmacology Biochemistry and Behavior.

A rapid method for evaluating the behavioral effects of phencyclidine-like dissociative anesthetics in mice

P. Skolnick, G. Evoniuk, R. P. Hertzman, 2006, Psychopharmacology.

Synthetic Analogues of Conantokin‐G: NMDA Antagonists Acting Through a Novel Polyamine‐Coupled Site

P. Skolnick, L. Otvos, G. Szendrei, 1996, Journal of neurochemistry.

Neurotrophic actions of the novel AMPA receptor potentiator, LY404187, in rodent models of Parkinson's disease.

K. Whalley, P. Skolnick, M. O'Neill, 2004, European journal of pharmacology.

Regulation of BDNF expression in primary neuron culture by LY392098, a novel AMPA receptor potentiator

P. Skolnick, B. Legutko, X. Li, 2001, Neuropharmacology.

A Multicenter, Placebo‐Controlled, Double‐Blind, Randomized Study of Efficacy and Safety of Ocinaplon (DOV 273,547) in Generalized Anxiety Disorder

P. Czobor, P. Skolnick, B. Beer, 2010, CNS neuroscience & therapeutics.

An AMPA receptor potentiator modulates hippocampal expression of BDNF: an in vivo study

David Bleakman, P. Skolnick, M. O'Neill, 2002, Neuropharmacology.

Enhancement of Antidepressant Potency by a Potentiator of AMPA Receptors

P. Skolnick, Xia Li, J. Witkin, 2003, Cellular and Molecular Neurobiology.

Antidepressant-like actions of an AMPA receptor potentiator (LY392098)

P. Skolnick, M. Clay, T. Lindstrom, 2001, Neuropharmacology.

Characteristics of [3H](+)-amphetamine binding sites in the rat central nervous system.

S. Paul, R. Hauger, P. Skolnick, 1984, Life sciences.

Glucose regulates [3H](+)-amphetamine binding and Na+K+ ATPase activity in the hypothalamus: A proposed mechanism for the glucostatic control of feeding and satiety

S. Paul, A. Janowsky, R. Hauger, 1986, Brain Research Bulletin.

Chronic administration of a glycine partial agonist alters the expression of N-methyl-D-aspartate receptor subunit mRNAs.

P. Skolnick, L. Fossom, P. Boyer, 1997, The Journal of pharmacology and experimental therapeutics.

Chronic treatment with 1-aminocyclopropanecarboxylic acid desensitizes behavioral responses to compounds acting at the N-methyl-d-aspartate receptor complex

P. Skolnick, K. Boje, A. Young, 2005, Psychopharmacology.

Differential electrophysiological and behavioral responses to optically active derivatives of phencyclidine

S. Paul, P. Skolnick, B. Hoffer, 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

The NMDA antagonist memantine blocks the expression and maintenance of morphine dependence

P. Skolnick, P. Popik, 1996, Pharmacology Biochemistry and Behavior.

Ca2+ antagonists effect an antidepressant-like adaptation of the NMDA receptor complex.

P. Skolnick, P. Popik, G. Nowak, 1993, European journal of pharmacology.

One Good Decision: The Policy Argument for Extended Release Naltrexone in the Criminal Justice Setting

P. Skolnick, Stephen Koppel, 2017 .

Are Glutamatergic Pathways Involved in the Pathophysiology of Anxiety

T. Insel, J. Winslow, P. Skolnick, 1991 .

Putative partial agonist 1-aminocyclopropanecarboxylic acid acts concurrently as a glycine-site agonist and a glutamate-site antagonist at N-methyl-D-aspartate receptors.

P. Skolnick, M. Benveniste, L. Fossom, 1999, Molecular pharmacology.

The antidepressant-like effects of glutamatergic drugs ketamine and AMPA receptor potentiator LY 451646 are preserved in bdnf +/− heterozygous null mice

E. Castrén, P. Skolnick, T. Rantamäki, 2012, Neuropharmacology.

1-Aminocyclopropanecarboxylic acid (ACPC) produces procognitive but not antipsychotic-like effects in rats

P. Skolnick, P. Popik, M. Hołuj, 2014, Psychopharmacology.

The Design, Synthesis and Structure–Activity Relationship of Mixed Serotonin, Norepinephrine and Dopamine Uptake Inhibitors

P. Skolnick, Zhengming Chen, Ji Yang, 2008 .

Preclinical and clinical pharmacology of DOV 216,303, a "triple" reuptake inhibitor.

P. Czobor, P. Skolnick, P. Popik, 2006, CNS drug reviews.

Pharmacological Profile of the “Triple” Monoamine Neurotransmitter Uptake Inhibitor, DOV 102,677

A. Janowsky, P. Skolnick, P. Popik, 2006, Cellular and Molecular Neurobiology.

Modulation of the Benzodiazepine/GABA Receptor Chloride Ionophore Complex: Evidence for an Asymmetrical Response of GABA-Gated Chloride Channels to Stress

P. Skolnick, T. Mcintyre, R. Trullás, 1989 .

Efficacy and tolerability of the novel triple reuptake inhibitor amitifadine in the treatment of patients with major depressive disorder: a randomized, double-blind, placebo-controlled trial.

M. Fava, P. Czobor, P. Skolnick, 2012, Journal of psychiatric research.

Failed trials for central nervous system disorders do not necessarily invalidate preclinical models and drug targets

M. Geyer, P. O’Donnell, M. Millan, 2016, Nature Reviews Drug Discovery.

Neurochemical Actions of Anesthetics at the GABAA Receptors

P. Skolnick, E. Moody, 2000 .

Medication development in opioid addiction: Meaningful clinical end points

N. Volkow, W. Compton, E. Wargo, 2018, Science Translational Medicine.

A benzodiazepine receptor inverse agonist inhibits stress-induced ulcer formation

P. Skolnick, R. Trullás, H. Ginter, 1987, Pharmacology Biochemistry and Behavior.

Anxioselective anxiolytics: can less be more?

P. Skolnick, A. Lippa, A. Basile, 2004, European Journal of Pharmacology.

The Anxioselective Agent 7-(2-Chloropyridin-4-yl)pyrazolo-[1,5-a]-pyrimidin-3-yl](pyridin-2-yl)methanone (DOV 51892) Is More Efficacious Than Diazepam at Enhancing GABA-Gated Currents at α1 Subunit-Containing GABAA Receptors

P. Skolnick, P. Popik, G. Nowak, 2006, Journal of Pharmacology and Experimental Therapeutics.

3-Hydroxymethyl-β-carboline antagonizes some pharmacologic actions of diazepam

S. Paul, J. Crawley, P. Skolnick, 1981 .

Putative endogenous ligands for the benzodiazepine receptor.

F. Goodwin, S. Paul, P. Skolnick, 1979, Life sciences.

Magic Bullets and Arrows: Biologic Approaches to Treat Substance Use Disorders

N. Volkow, P. Skolnick, 2016 .

Addiction Therapeutics: Obstacles and Opportunities

N. Volkow, P. Skolnick, 2012, Biological Psychiatry.

New Medications for Substance Use Disorders: Challenges and Opportunities

N. Volkow, P. Skolnick, 2012, Neuropsychopharmacology.

From bench to bedside: mGluR2 positive allosteric modulators as medications to treat substance use disorders

P. Skolnick, A. Cross, J. Acri, 2017, Psychopharmacology.

Trends in opioid analgesic abuse and mortality in the United States.

P. Skolnick, D. McCann, Robert B Bolash, 2015, The New England journal of medicine.

Characterization of the Antinociceptive Actions of Bicifadine in Models of Acute, Persistent, and Chronic Pain

A. Janowsky, P. Skolnick, P. Popik, 2007, Journal of Pharmacology and Experimental Therapeutics.

Response to Marks, Abramowitz, and Spielmans Letter to the Editor

M. Fava, P. Czobor, P. Skolnick, 2012 .

Distinct structural requirements for the direct and indirect actions of the anaesthetic etomidate at GABA(A) receptors.

P. Skolnick, C. Knauer, E. Moody, 1998, Toxicology letters.

Anticonvulsant doses of inosine result in brain levels sufficient to inhibit [3H] diazepam binding

S. Paul, P. Skolnick, E. Trams, 2004, Psychopharmacology.

Demonstration of [3H] diazepam binding to benzodiazepine receptors in vivo.

S. Paul, P. Skolnick, M. J. Williamson, 1978, Life sciences.

Demonstration of an endogenous, competitive inhibitor(s) of [3H] diazepam binding in bovine brain.

F. Goodwin, S. Paul, P. Skolnick, 1978, Life sciences.

A benzodiazepine receptor-mediated model of anxiety. Studies in nonhuman primates and clinical implications.

T. Insel, S. Paul, P. Ninan, 1984, Archives of general psychiatry.

[3H]ATPA: a high affinity ligand for GluR5 kainate receptors

P. Skolnick, P. Krogsgaard‐Larsen, D. Bleakman, 1999, Neuropharmacology.

Brain-specific benzodiazepine receptors and putative endogenous benzodiazepine-like compounds.

F. Goodwin, S. Paul, P. Skolnick, 1980, Biological psychiatry.

Demonstration of two new endogenous “benzodiazepine-like” compounds from brain

S. Paul, P. Skolnick, P. Marangos, 1979, Psychiatry Research.

Mitigating the Effects of Nonadherence in Clinical Trials

Earle E. Bain, P. Skolnick, T. Shiovitz, 2016, Journal of clinical pharmacology.

Morphine inhibits the development of allogeneic immune responses in mouse lymph node.

P. Skolnick, R. Maity, R. Mukherjee, 1995, Immunopharmacology.

Morphine-induced thymic hypoplasia is glucocorticoid-dependent.

P. Skolnick, T. Mcintyre, Y. Sei, 1991, Journal of immunology.

Intra- and interstrain differences in models of “behavioral despair”

P. Skolnick, M. Clay, T. Lindstrom, 2001, Pharmacology Biochemistry and Behavior.

Purines as endogenous ligands of the benzodiazepine receptor.

S. Paul, P. Skolnick, P. Marangos, 1980, Federation proceedings.

Brain benzodiazepine levels following intravenous administration of [34]diazepam: relationship to the potentiation of purinergic depression of central nervous system neurons.

S. Paul, P. Skolnick, P. Marangos, 1979, Canadian journal of physiology and pharmacology.

Suppression of the immune response by benzodiazepine receptor inverse agonists

S. Paul, P. Skolnick, E. E. Hanna, 1987, Journal of Neuroimmunology.

Interaction of clonidine with pre- and post-synaptic adrenergic receptors of rat brain: effects on cyclic AMP-generating systems.

P. Skolnick, J. Daly, 1976, European journal of pharmacology.

β-Adrenergic-control of cyclic AMP-generating systems in cerebellum: Pharmacological heterogeneity confirmed by destruction of interneurons

D. Woodward, P. Skolnick, B. Hoffer, 1976, Experimental Neurology.

Benzodiazepine receptor-mediated experimental "anxiety" in primates.

S. Paul, P. Ninan, P. Skolnick, 1982, Science.

(2S,4R)-4-methylglutamic acid (SYM 2081): a selective, high-affinity ligand for kainate receptors.

P. Skolnick, T. Giordano, P. Månsson, 1997, The Journal of pharmacology and experimental therapeutics.

Elevated Brain Concentrations of 1, 4-Benzodiazepines in Fulminant Hepatic Failure

L. Pannell, P. Skolnick, Roger Williams, 1992 .

Benzodiazepine-receptor mediated inhibition of isolation-induced aggression in mice

S. Paul, P. Skolnick, G. Reed, 1985, Pharmacology Biochemistry and Behavior.

Neuropharmacological antagonism of the beta-carboline-induced "anxiety" response in rhesus monkeys

S. Paul, J. Crawley, P. Ninan, 1985, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Effects of beta-carboline-3-carboxylic acid ethyl ester on suppressed and non-suppressed responding in the rhesus monkey.

S. Paul, P. Skolnick, J. Glowa, 1986, European journal of pharmacology.

An anxiogenic benzodiazepine receptor ligand induces learned helplessness.

S. Maier, S. Paul, J. Crawley, 1985, European journal of pharmacology.

Do benzodiazepine receptors mediate the anticonflict action of pentobarbital?

S. Paul, W. Mendelson, P. Skolnick, 1983, Life sciences.

Specific [3H] beta-phenylethylamine binding sites in rat brain.

S. Paul, R. Hauger, P. Skolnick, 1982, European journal of pharmacology.

Brain α-adrenergic receptors: comparison of [3H]WB 4101 binding with norepinephrine-stimulated cyclic AMP accumulation in rat cerebral cortex

James N. Davis, C. D. Arnett, P. Skolnick, 1978, Brain Research.

Acute, stress-induced changes in the benzodiazepine/gamma-aminobutyric acid receptor complex are confined to the chloride ionophore.

S. Paul, P. Skolnick, H. Havoundjian, 1986, The Journal of pharmacology and experimental therapeutics.

Stress‐Induced Changes in t‐[35S]Butylbicyclophosphorothionate Binding to γ‐Aminobutyric Acid‐Gated Chloride Channels Are Mimicked by In Vitro Occupation of Benzodiazepine Receptors

P. Skolnick, H. Havoundjian, R. Trullás, 1987, Journal of neurochemistry.

Differences in the Biophysical Properties of the Benzodiazepine/γ‐Aminobutyric Acid Receptor Chloride Channel Complex in the Long‐Sleep and Short‐Sleep Mouse Lines

P. Skolnick, T. Mcintyre, R. Trullás, 1988, Journal of neurochemistry.

The permeability of y-aminobutyric acid-gated chloride channels is described by the binding of a "cage" convulsant,

S. Paul, P. Skolnick, 2022 .

Down-regulation of cortical β-adrenoceptors by chronic treatment with functional NMDA antagonists

P. Skolnick, G. Nowak, I. Paul, 2007, Psychopharmacology.

New concepts in the neurobiology of anxiety.

S. Paul, P. Skolnick, 1983, The Journal of clinical psychiatry.

Ro 15-4513 binding to GABAA receptors: Subunit composition determines ligand efficacy

P. Skolnick, G. Wong, 1992, Pharmacology Biochemistry and Behavior.

Environmentally-induced modification of the benzodiazepine/GABA receptor coupled chloride ionophore

S. Paul, P. Skolnick, H. Havoundjian, 2004, Psychopharmacology.

Triple uptake inhibitors: therapeutic potential in depression and beyond

P. Skolnick, Zhengming Chen, Phil Skolnick, 2007, Expert opinion on investigational drugs.

"Broad spectrum" antidepressants: is more better for the treatment of depression?

A. Janowsky, P. Skolnick, P. Popik, 2003, Life sciences.

Adaptation of the N-methyl-D-aspartate receptor complex following chronic antidepressant treatments.

P. Skolnick, P. Popik, G. Nowak, 1994, The Journal of pharmacology and experimental therapeutics.

Radiation Inactivation Studies of the Benzodiazepine/γ‐Aminobutyric Acid/Chloride Ionophore Receptor Complex

S. Paul, R. D. Schwartz, P. Skolnick, 1985, Journal of neurochemistry.

A quantitative relationship between Cl− enhanced [3H]flunitrazepam and binding to the benzodiazepine/GABA receptor chloride ionophore complex

P. Skolnick, H. Havoundjian, 1986 .

Anion Regulation of Agonist and Inverse Agonist Binding to Benzodiazepine Receptors

P. Skolnick, G. Evoniuk, 1988, Journal of neurochemistry.

Benzodiazepine Receptor-Mediated “Anxiety” in Primates

T. Insel, S. Paul, J. Crawley, 1985 .

Pharmacological Properties of Recombinant “Diazepam-insensitive” GABAA Receptors

P. Skolnick, D. Gunnersen, C. M. Kaufman, 1996, Neuropharmacology.

Synthesis of [3H]tert‐butyl 8‐chloro‐5,6‐dihydro‐5‐methyl‐6‐oxo‐4h‐imidazo[1,5‐a][1,4]benzodiazepine 3‐carboxylate, a selective, high affinity ligand for the diazepam insensitive (DI) subtype of the benzodiazepine receptor

P. Skolnick, K. Rice, G. Wong, 1992 .

Glutamate-Based Antidepressants: Preclinical Psychopharmacology

P. Skolnick, J. Wierońska, Andrzej Pilc, 2013, Biological Psychiatry.

A pretest procedure reliably predicts performance in two animal models of inescapable stress

S. Paul, J. Crawley, P. Skolnick, 1989, Pharmacology Biochemistry and Behavior.

NMDA antagonist properties of the putative antiaddictive drug, ibogaine.

P. Skolnick, P. Popik, M. Benveniste, 1995, The Journal of pharmacology and experimental therapeutics.

Ibogaine as a glutamate antagonist: relevance to its putative antiaddictive properties.

P. Skolnick, 2001, The Alkaloids. Chemistry and biology.

Diazepam enhancement of GABA-gated currents in binary and ternary GABAA receptors

P. Skolnick, G. Wong, A. Valeyev, 1997, Journal of Molecular Neuroscience.

Pharmacological, electrophysiological, and neurochemical actions of the convulsant benzodiazepine Ro 5-4864 (4'-chlordiazepam).

P. Skolnick, R. Quirion, B. Weissman, 1983, Advances in biochemical psychopharmacology.

Noncompetitive Inhibition of N‐Methyl‐D‐Aspartate by Conantokin‐G: Evidence for an Allosteric Interaction at Polyamine Sites

P. Skolnick, K. Boje, M. Maccecchini, 1992, Journal of neurochemistry.

Fighting Fire with Fire: Development of Intranasal Nalmefene to Treat Synthetic Opioid Overdose

P. Skolnick, R. Crystal, P. Krieter, 2019, The Journal of Pharmacology and Experimental Therapeutics.

Nitroimipramines — Synthesis and pharmacological effects of potent long-acting inhibitors of [3H] serotonin uptake and [3H] imipramine binding

S. Paul, P. Skolnick, K. Rice, 1982, Naunyn-Schmiedeberg's Archives of Pharmacology.

Subcellular distribution of high affinity [3H]imipramine binding and [3H]serotonin uptake in rat brain.

S. Paul, P. Skolnick, M. Rehavi, 1983, European journal of pharmacology.

[3H]2-Nitroimipramine: a selective "slowly-dissociating" probe of the imipramine binding site ("serotonin transporter") in platelets and brain.

S. Paul, P. Skolnick, K. Rice, 1983, Life sciences.

2-nitroimipramine: a selective irreversible inhibitor of [3H] serotonin uptake and [3H] imipramine binding in platelets.

F. Goodwin, S. Paul, P. Skolnick, 1981, Biochemical and biophysical research communications.

The involvement of the benzodiazepine receptor in hepatic encephalopathy: evidence for the presence of a benzodiazepine receptor ligand.

P. Skolnick, A. Basile, E. Jones, 1990, Advances in biochemical psychopharmacology.

DOV 216,303, a “Triple” Reuptake Inhibitor: Safety, Tolerability, and Pharmacokinetic Profile

P. Czobor, P. Skolnick, B. Beer, 2004, Journal of clinical pharmacology.

Enhanced Intranasal Absorption of Naltrexone by Dodecyl Maltopyranoside: Implications for the Treatment of Opioid Overdose

P. Skolnick, C. N. Chiang, R. Crystal, 2019, Journal of clinical pharmacology.

Pharmacotherapy of Substance Use Disorders

P. Skolnick, A. Douaihy, J. Acri, 2013 .

The Triple Uptake Inhibitor (1R,5S)-(+)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0] Hexane Hydrochloride (DOV 21947) Reduces Body Weight and Plasma Triglycerides in Rodent Models of Diet-Induced Obesity

M. Tschöp, P. Skolnick, L. Shearman, 2008, Journal of Pharmacology and Experimental Therapeutics.

Internucleosomal DNA fragmentation in gerbil hippocampus following forebrain ischemia

R. Lin, P. Skolnick, A. Basile, 1994, Neuroscience Letters.

Binding of an AMPA receptor potentiator ([3H]LY395153) to native and recombinant AMPA receptors 1 The first two authors contributed equally to this work. 1

P. Skolnick, W. J. Wheeler, A. Linden, 2001, Neuropharmacology.

Nitric oxide does not mediate the neurotrophic effects of excitatory amino acids in cultured cerebellar granule neurons.

P. Skolnick, K. Boje, 1992, European journal of pharmacology.

Spermine‐Induced Toxicity in Cerebellar Granule Neurons Is Independent of Its Actions at NMDA Receptors

P. Skolnick, Jeffrey Segal, 2000, Journal of neurochemistry.

Synthesis, resolution, and biological evaluation of the four stereoisomers of 4-methylglutamic acid: selective probes of kainate receptors.

P. Skolnick, J. Pelletier, Z. Gu, 1995, Journal of medicinal chemistry.

Inhibition of [3H]Diazepam and [3H]3‐Carboethoxy‐β‐Carboline Binding by Irazepine: Evidence for Multiple “Domains” of the Benzodiazepine Receptor

S. Paul, P. Skolnick, M. Schweri, 1982, Journal of neurochemistry.

Binding of [3H]ethyl‐β‐carboline‐3‐carboxylate to brain benzodiazepine receptors

P. Skolnick, K. C. Rice, M. Cain, 1981, FEBS letters.

[3H]1-aminocyclopropanecarboxylic acid, a novel probe for strychnine- insensitive glycine receptors.

P. Skolnick, P. Popik, G. Nowak, 1995, European journal of pharmacology.

Chronic administration of imipramine and citalopram alters the expression of NMDA receptor subunit mRNAs in mouse brain

P. Skolnick, L. Fossom, P. Boyer, 1998, Journal of Molecular Neuroscience.

Ontogeny of glycine-enhanced [3H]MK-801 binding to N-methyl-D-aspartate receptor-coupled ion channels.

P. Skolnick, K. Boje, 1992, Brain research. Developmental brain research.

N -Methyl-d-Aspartate (NMDA) Antagonists for the Treatment of Depression

P. Skolnick, P. Popik, R. Trullás, 2010 .

Current perspectives on the development of non-biogenic amine-based antidepressants.

F. Bymaster, P. Skolnick, B. Legutko, 2001, Pharmacological research.

Adaptation of cortical NMDA receptors by chronic treatment with specific serotonin reuptake inhibitors.

P. Skolnick, P. Popik, G. Nowak, 1998, European journal of pharmacology.

Adaptation of the NMDA receptor in rat cortex following chronic electroconvulsive shock or imipramine.

P. Skolnick, G. Nowak, I. Paul, 1993, European journal of pharmacology.

Adaptive changes in the N-methyl-D-aspartate receptor complex after chronic treatment with imipramine and 1-aminocyclopropanecarboxylic acid.

P. Skolnick, G. Nowak, I. Paul, 1993, The Journal of pharmacology and experimental therapeutics.

AMPA receptor function is altered in GLUR2-deficient mice

E. Nisenbaum, P. Skolnick, Hong Yu, 2001, Journal of Molecular Neuroscience.

Low doses of muscimol produce anticonflict actions in the lateral septum of the rat

J. Crawley, P. Skolnick, S. Paul, 1986, Neuropharmacology.

CNS benzodiazepine receptors: Physiological studies and putative endogenous ligands

F. Goodwin, S. Paul, P. Skolnick, 1979, Pharmacology Biochemistry and Behavior.

Pyrazolo(4,3‐c)quinolines with High Affinities for “Diazepam‐ Insensitive” (DI)GABAA/Benzodiazepine Receptors

P. Skolnick, G. Wong, Z. Gu, 1993 .

The benzodiazepine/GABA receptor chloride channel complex

P. Skolnick, S. Paul, 1988 .

Differential effects of compounds that act at strychnine-insensitive glycine receptors in a punishment procedure.

P. Skolnick, E. Viu, R. Trullás, 1994, The Journal of pharmacology and experimental therapeutics.

Stereoselective actions of halothane at GABA(A) receptors.

P. Skolnick, B. Harris, E. Moody, 1998, European journal of pharmacology.

Protection against the lethal effects of pentobarbital in mice by a benzodiazepine receptor inverse agonist, 6,7-dimethoxy-4-ethyl-3-carbomethoxy-beta-carboline.

S. Paul, P. Skolnick, G. Reed, 1987, The Journal of clinical investigation.

Anomalous rectifying properties of 'diazepam-insensitive' GABA(A) receptors.

P. Skolnick, C. Knauer, M. Strakhova, 1998, European journal of pharmacology.

Contribution of “diazepam-insensitive” GABAA receptors to the alcohol antagonist properties of Ro 15–4513 and related imidazobenzodiazepines

P. Skolnick, B. Harris, Z. Gu, 1995, Pharmacology Biochemistry and Behavior.

High-performance fast affinity chromatographic purification of anti-benzodiazepine antibodies.

P. Skolnick, A. Newman, K. Rice, 1986, Journal of Chromatography A.

The benzodiazepines and inosine antagonize caffeine-induced seizures

S. Paul, P. Skolnick, P. Marangos, 2004, Psychopharmacology.

Requirements for high affinity binding of glycine analogs to the glycine site of the NMDA receptor complex.

P. Skolnick, J. Bowen, I. Paul, 1993, European journal of pharmacology.

An endogenous modulator of N-methyl-D-aspartate receptor-coupled glycine receptors.

P. Skolnick, J. Marvizón, 1990, European journal of pharmacology.

Can 'differential display' methodologies make an impact on biological psychiatry?

P. Skolnick, M. Strakhova, 2001, The international journal of neuropsychopharmacology.

Synthesis of novel imidazobenzodiazepines as probes of the pharmacophore for "diazepam-insensitive" GABAA receptors.

P. Skolnick, J. Cook, B. Harris, 1995, Journal of medicinal chemistry.

Strain differences in susceptibility to the convulsant actions of 3-carbomethoxy-β-carboline

S. Paul, P. Skolnick, M. Schweri, 1983, Pharmacology Biochemistry and Behavior.

Benzodiazepine receptor-mediated experimental ‘anxiety’ in rhesus monkeys after infusion of 3-carboethoxy-ß-carboline (ß-CCE)

T. Insel, S. Paul, P. Ninan, 1983 .

Transduction of a discriminative stimulus through a diazepam-insensitive gamma-aminobutyric acidA receptor.

P. Skolnick, J. Witkin, G. Wong, 1993, The Journal of pharmacology and experimental therapeutics.

Anxiolytic properties of 1-aminocyclopropanecarboxylic acid, a ligand at strychnine-insensitive glycine receptors

P. Skolnick, R. Trullás, B. Jackson, 1989, Pharmacology, Biochemistry and Behavior.

Synthetic and computer-assisted analysis of the structural requirements for selective, high-affinity ligand binding to diazepam-insensitive benzodiazepine receptors.

P. Skolnick, K. Koehler, S. Ananthan, 1993, Journal of medicinal chemistry.

Embryonic Rat Hippocampal Neurons and GABAA Receptor Subunit-Transfected Non-neuronal Cells Release GABA Tonically

J. Barker, P. Skolnick, G. Wong, 1998, The Journal of Membrane Biology.

[3H]RY 80: A high-affinity, selective ligand for gamma-aminobutyric acidA receptors containing alpha-5 subunits.

P. Skolnick, R. Liu, J. Cook, 1997, The Journal of pharmacology and experimental therapeutics.

[3H]AHN 086 acylates peripheral benzodiazepine receptors in the rat pineal gland

J. Reig, P. Skolnick, A. Newman, 1989, FEBS letters.

Buspirone attenuates learned helplessness behavior in rats

J. Crawley, P. Skolnick, R. Drugan, 1987 .

Immunoenhancing Effects of Alprazolam, a Benzodiazepine Receptor Agonist a

P. Skolnick, E. Fride, P. K. Arora, 1992, Annals of the New York Academy of Sciences.

Immunoenhancing effects of alprazolam in mice.

P. Skolnick, E. Fride, P. K. Arora, 1990, Life sciences.

MK-801, but not drugs acting at strychnine-insensitive glycine receptors, attenuate methamphetamine nigrostriatal toxicity

P. Skolnick, R. Layer, Lashun R. Bland, 1993, Brain Research.

Synthesis of novel 3-substituted beta-carbolines as benzodiazepine receptor ligands: probing the benzodiazepine receptor pharmacophore.

P. W. Codding, P. Skolnick, P Skolnick, 1988, Journal of medicinal chemistry.

Glutamate receptor ligands

P. Skolnick, 2000 .

A single residue contributes sensitivity to allosteric modulation of AMPA receptors by LY395153.

E. Nisenbaum, P. Skolnick, A. Linden, 2002, European journal of pharmacology.

Synthesis of N,N'-substituted piperazine and homopiperazine derivatives with polyamine-like actions at N-methyl-D-aspartate receptors.

P. Skolnick, B. de Costa, G. Li, 1995, Journal of medicinal chemistry.

A Single Amino Acid Residue on the α5 Subunit (Ile215) Is Essential for Ligand Selectivity at α5β3γ2 γ-Aminobutyric AcidA Receptors

P. Skolnick, J. Cook, S. C. Harvey, 2000 .

Regulation of renal peripheral benzodiazepine receptors by anion transport inhibitors.

P. Skolnick, A. Basile, H. Lueddens, 1988, Life sciences.

Polyamine-like actions of peptides derived from conantokin-G, an N-methyl-D-aspartate (NMDA) antagonist.

P. Skolnick, M. Pennington, N. Nashed, 1993, The Journal of biological chemistry.

Chronic exposure to benzodiazepine receptor ligands uncouples the gamma-aminobutyric acid type A receptor in WSS-1 cells.

P. Skolnick, G. Wong, T. Lyon, 1994, Molecular pharmacology.

Preservation of "peripheral" benzodiazepine receptors: differential effects of freezing on [3H]Ro 5-4864 and [3H]PK 11195 binding.

P. Skolnick, A. Basile, 1987, Journal of pharmacological methods.

Novel irreversible ligands specific for "peripheral" type benzodiazepine receptors: (+/-)-, (+)-, and (-)-1-(2-chlorophenyl)-N-(1-methylpropyl)-N- (2-isothiocyanatoethyl)-3-isoquinolinecarboxamide and 1-(2-isothiocyanatoethyl)-7-chloro-1,3-dihydro-5-(4-chlorophenyl )-2H-1,4-benzodiazepin-2-one.

P. Skolnick, A. Newman, K. Rice, 1987, Journal of medicinal chemistry.

The GABAA receptor complex in hepatic encephalopathy. Autoradiographic evidence for the presence of elevated levels of a benzodiazepine receptor ligand.

P. Skolnick, A. Basile, E. Jones, 1990, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.

Benzodiazepine receptor ligands and the syndrome of hepatic encephalopathy.

P. Skolnick, E. Jones, 1990, Progress in liver diseases.

Pharmacologic and behavioral effects of EMD 28422: A novel purine which enhances (3H) diazepam binding to brain benzodiazepine receptors

S. Paul, P. Skolnick, P. Marangos, 1980, Pharmacology Biochemistry and Behavior.

High affinity and stereospecific binding of [3H]d-amphetamine to rat brain.

S. Paul, R. Hauger, P. Skolnick, 1982, European journal of pharmacology.

Modulation of glutamate receptors: Strategies for the development of novel antidepressants

P. Skolnick, 2002, Amino Acids.

The secrets of a successful clinical trial: compliance, compliance, and compliance.

Pál Czobor, P. Czobor, P. Skolnick, 2011, Molecular interventions.

Preclinical Models of Neurologic and Psychiatric Disorders

P. Skolnick, 2003 .

Aldosterone-reversible decrease in the density of renal peripheral benzodiazepine receptors in the rat after adrenalectomy.

P. Skolnick, A. Basile, N. Ostrowski, 1987, Journal of Pharmacology and Experimental Therapeutics.

Adrenalectomy reduces the density of 'peripheral-type' binding sites for benzodiazepines in the rat kidney.

S. Paul, P. Skolnick, A. Basile, 1985, European journal of pharmacology.

Pharmacokinetic Properties of an FDA-approved Intranasal Nalmefene Formulation for the Treatment of Opioid Overdose.

P. Skolnick, R. Crystal, M. Ellison, 2023, Clinical pharmacology in drug development.

Characterization of [3H]Ro5-4864 binding to "peripheral" benzodiazepine receptors in guinea pig alveolar type II cells.

P. Skolnick, M. Sikpi, S. Das, 1987, Biochemical pharmacology.

Demonstration and characterization of an endogenous inhibitor of GABA-enhanced [3H]-diazepam binding from bovine cerebral cortex.

S. Paul, P. Skolnick, M. Brownstein, 1981, Advances in biochemical psychopharmacology.

Dihydropyridine calcium channel antagonist binding in non-mammalian vertebrates: characterization and relationship to ‘peripheral-type’ binding sites for benzodiazepines

S. Paul, J. Barrett, P. Skolnick, 1986, Brain Research.

Characterization of Sodium‐Dependent [3H]GBR‐12935 Binding in Brain: A Radioligand for Selective Labelling of the Dopamine Transport Complex

S. Paul, A. Janowsky, P. Skolnick, 1986, Journal of neurochemistry.

Phencyclidine increases the affinity of dihydropyridine calcium channel antagonist binding in rat brain

P. Skolnick, G. Bolger, M. Rafferty, 1985, Naunyn-Schmiedeberg's Archives of Pharmacology.

Preclinical Pharmacology of Buspirone Hydrochloride

S. Paul, P. Skolnick, B. Weissman, 1984, Pharmacotherapy.

Monoaminergic involvement in the pharmacological actions of buspirone

P. Skolnick, M. Youdim, B. Weissman, 1985, British Journal of Pharmacology.

Buspirone: chemistry, pharmacology, and behavior.

P. Skolnick, S. Paul, 1982, The Journal of clinical psychiatry.

Blockade of central beta-adrenergic receptors by tazolol (1-isopropylamino-3-(2-thiazoloxy)-2-propanol).

P. Skolnick, J. Daly, L. Stalvey, 1977, Life Science.

Response : Seizures in Drug-Treated Animals

J. Crawley, P. Suzdak, R. D. Schwartz, 1987, Science.

β-Carboline-Induced Anxiety States

S. Paul, J. Crawley, P. Skolnick, 1984 .

Do benzodiazepine receptors play a role in sleep regulation? Studies with the benzodiazepine antagonist, 3-hydroxymethyl-beta-carboline (3-HMC).

S. Paul, W. Mendelson, P. Skolnick, 1982, Progress in clinical and biological research.

meta- and para-isothiocyanato-t-butylbicycloorthobenzoate: irreversible ligands of the gamma-aminobutyric acid-regulated chloride ionophore.

P. Skolnick, K. Rice, B. de Costa, 1989, Molecular pharmacology.

beta-Carbolines and benzodiazepine receptors: structure-activity relationships and pharmacologic activity.

S. Paul, J. Crawley, W. Mendelson, 1982, Progress in clinical and biological research.

In vivo effects of two novel alkylating benzodiazepines, irazepine and kenazepine

S. Paul, P. Skolnick, K. Rice, 1981, Pharmacology Biochemistry and Behavior.

Differential regulation of μ‐opiate receptors in heroin‐ and morphine‐dependent rats

P. Skolnick, B. Weissman, G. Bolger, 1988 .

Interrelationship between catecholamine-stimulated formation of adenosine 3',5'-monophosphate in cerebellar slices and inhibitory effects on cerebellar Purkinje cells: antagonism by neuroleptic compounds.

P. Skolnick, B. Hoffer, R. Freedman, 1976, The Journal of pharmacology and experimental therapeutics.

Special Section on The Opioid Crisis Fighting Fire with Fire: Development of Intranasal Nalmefene to Treat Synthetic Opioid Overdose

P. Skolnick, R. Crystal, P. Krieter, 2019 .

International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function.

G. Biggio, R. Olsen, W. Sieghart, 1998, Pharmacological reviews.

Preclinical Evaluation of the Abuse Potential of the Analgesic Bicifadine

P. Skolnick, K. Nicholson, A. Basile, 2009, Journal of Pharmacology and Experimental Therapeutics.

Increased Brain Levels of Platelet‐Activating Factor in a Murine Acquired Immune Deficiency Syndrome Are NMDA Receptor‐Mediated

P. Skolnick, H. Morse, A. Basile, 1996, Journal of neurochemistry.

Measures of outcome for stimulant trials: ACTTION recommendations and research agenda.

Brian D. Kiluk, K. Preston, G. Woody, 2016, Drug and Alcohol Dependence.

Biologic Approaches to Treat Substance-Use Disorders.

P. Skolnick, 2015, Trends in pharmacological sciences.

Therapeutic doses of buspirone block D3 receptors in the living primate brain.

N. Volkow, J. Fowler, P. Skolnick, 2014, The international journal of neuropsychopharmacology.

Synthesis of 3,6-Disubstituted b-Carbolines Which Possess either Benzodiazepine Antagonist or Agonist Activity

P. Skolnick, H. Shannon, J. Cook, 1986 .

Syntheses of 5-Thienyl- and 5-Furyl-Substituted Benzodiazepines: Probes of the Pharmacophore for Benzodiazepine Receptor Agonists.

P. Skolnick, Weijiang Zhang, K. Koehler, 1995 .

A rapid and sensitive radioreceptor assay for tertiary amine tricyclic antidepressants.

F. Goodwin, P. Skolnick, M. Rehavi, 1980, Communications in psychopharmacology.

Glycine antagonists and partial agonists as novel anxiolytic/antidepressant agents

P. Skolnick, R. Trullás, 1991, European Neuropsychopharmacology.

The Opioid Epidemic: Crisis and Solutions.

P. Skolnick, 2018, Annual review of pharmacology and toxicology.