A. Calvo

A. Chiò, R. Mutani, A. Calvo, 2004, Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases.

Excitotoxicity and genetics of amyotrophic lateral sclerosis: effects of intracellular calcium accumulation on proteins encoded by the major genes underlying the disease

A. Chiò, A. Calvo, M. T. Rinaudo, 2021 .

C9ORF72 hexanucleotide repeat expansions in the Italian sporadic ALS population

F. Marrosu, A. Chiò, G. Mora, 2012, Neurobiology of Aging.

Comparative Analysis of C9orf72 and Sporadic Disease in a Large Multicenter ALS Population: The Effect of Male Sex on Survival of C9orf72 Positive Patients

A. Chiò, G. Mora, G. Logroscino, 2019, Front. Neurosci..

Brain hypermetabolism in amyotrophic lateral sclerosis: a FDG PET study in ALS of spinal and bulbar onset

A. Chiò, F. Nobili, A. Calvo, 2012, European Journal of Nuclear Medicine and Molecular Imaging.

Lifetime sport practice and brain metabolism in Amyotrophic Lateral Sclerosis

A. Chiò, F. Nobili, A. Calvo, 2020, NeuroImage: Clinical.

Physical activity and amyotrophic lateral sclerosis: A European population‐based case–control study

E. Beghi, G. Giussani, A. Chiò, 2014, Annals of neurology.

CHCH10 mutations in an Italian cohort of familial and sporadic amyotrophic lateral sclerosis patients

Janel O. Johnson, M. Nalls, A. Chiò, 2015, Neurobiology of Aging.

Genetic counselling in ALS: facts, uncertainties and clinical suggestions

A. Chiò, G. Mora, A. Calvo, 2013, Journal of Neurology Neurosurgery & Psychiatry.

The last months of life of people with amyotrophic lateral sclerosis in mechanical invasive ventilation: A qualitative study

A. Chiò, A. Calvo, S. Veronese, 2014, Amyotrophic lateral sclerosis & frontotemporal degeneration.

Association of Variants in the SPTLC1 Gene With Juvenile Amyotrophic Lateral Sclerosis

Sonja W. Scholz, Hannah A. Pliner, Janel O. Johnson, 2021, JAMA neurology.

Mutations in the SPTLC1 gene are a cause of amyotrophic lateral sclerosis that may be amenable to serine supplementation

Sonja W. Scholz, Hannah A. Pliner, Janel O. Johnson, 2019, bioRxiv.

The rare G93D mutation causes a slowly progressing lower motor neuron disease

A. Chiò, A. Calvo, C. Gellera, 2008, Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases.

Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis.

Timothy A. Miller, Sonja W. Scholz, Jennifer E. Phillips-Cremins, 2020, Neuron.

Trauma and amyotrophic lateral sclerosis: a european population-based case-control study from the EURALS consortium

E. Beghi, G. Giussani, A. Chiò, 2018, Amyotrophic lateral sclerosis & frontotemporal degeneration.

Physical Activity and Amyotrophic Lateral Sclerosis: A European Population-Based

E. Beghi, G. Giussani, A. Chiò, 2014 .

Neurobehavioral dysfunction in ALS has a negative effect on outcome and use of PEG and NIV

A. Chiò, A. Calvo, A. Montuschi, 2012, Neurology.

Non-invasive ventilation in amyotrophic lateral sclerosis: a 10 year population based study

A. Chiò, G. Mora, A. Calvo, 2011, Journal of Neurology, Neurosurgery & Psychiatry.

Idiopathic chronic inflammatory demyelinating polyneuropathy: an epidemiological study in Italy

A. Chiò, R. Mutani, A. Calvo, 2007, Journal of Neurology, Neurosurgery, and Psychiatry.

Phenotype Analysis of Fused in Sarcoma Mutations in Amyotrophic Lateral Sclerosis

A. Chiò, B. Traynor, A. Calvo, 2022, Neurology: Genetics.

A de novo nonsense mutation of the FUS gene in an apparently familial ALS case

A. Chiò, B. Traynor, A. Calvo, 2014 .

ALS/FTD phenotype in two Sardinian families carrying both C9ORF72 and TARDBP mutations

P. Tacconi, F. Marrosu, A. Chiò, 2012, Journal of Neurology, Neurosurgery & Psychiatry.

Two Italian kindreds with familial amyotrophic lateral sclerosis due to FUS mutation

A. Chiò, G. Mora, B. Traynor, 2009, Neurobiology of Aging.

G-CSF (filgrastim) treatment for amyotrophic lateral sclerosis: protocol for a phase II randomised, double-blind, placebo-controlled, parallel group, multicentre clinical study (STEMALS-II trial)

A. Chiò, A. Calvo, V. La Bella, 2020, BMJ Open.

The additive effect of genetic modifiers on ALS prognosis: a population-based study

C. Dalgård, A. Chiò, B. Traynor, 2022, medRxiv.

G‐quadruplex‐binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo

L. Partridge, A. Chiò, H. Zetterberg, 2017, EMBO molecular medicine.

Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS

Sonja W. Scholz, Janel O. Johnson, D. Hernandez, 2010, Neuron.

A patient carrying a homozygous p.A382T TARDBP missense mutation shows a syndrome including ALS, extrapyramidal symptoms, and FTD

A. Chiò, B. Traynor, A. Calvo, 2011, Neurobiology of Aging.

Exploring the phenotype of Italian patients with ALS with intermediate ATXN2 polyQ repeats

A. Chiò, G. Mora, B. Traynor, 2022, Journal of Neurology, Neurosurgery, and Psychiatry.

Can amyotrophic lateral sclerosis progression really pause? A cohort study using the medical research council scale

A. Chiò, A. Calvo, C. Moglia, 2021, Amyotrophic lateral sclerosis & frontotemporal degeneration.

What is amyotrophic lateral sclerosis prevalence?

A. Chiò, A. Calvo, C. Moglia, 2021, Journal of the Neurological Sciences.

Comorbidity of Cervical Spondylogenic Myelopathy and Amyotrophic Lateral Sclerosis: When Electromyography Makes the Difference in Diagnosis

A. Chiò, D. Garbossa, A. Calvo, 2020, European Neurology.

Early weight loss in amyotrophic lateral sclerosis: outcome relevance and clinical correlates in a population-based cohort

A. Chiò, G. Mora, A. Calvo, 2019, Journal of Neurology Neurosurgery & Psychiatry.

Multicenter validation of [18F]-FDG PET and support-vector machine discriminant analysis in automatically classifying patients with amyotrophic lateral sclerosis versus controls

A. Chiò, P. van Damme, K. Van Laere, 2018, Amyotrophic lateral sclerosis & frontotemporal degeneration.

Acoustic reflex patterns in amyotrophic lateral sclerosis

A. Chiò, A. Calvo, R. Albera, 2017, European Archives of Oto-Rhino-Laryngology.

CHCH10 mutations in an Italian cohort of familial and sporadic ALS patients

Marcella, Lunetta, Salvi, 2015 .

An ALS case with a novel D90N-SOD1 heterozygous missense mutation

A. Chiò, A. Calvo, C. Moglia, 2012, Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases.

Monomelic amyotrophy is not always benign: A case report

A. Chiò, A. Calvo, C. Moglia, 2011, Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases.

THEME 8 CLINICAL IMAGING AND ELECTROPHYSIOLOGY IMG-01 First-recruited motor units adopt a faster phenotype in amyotrophic lateral sclerosis

A. Calvo, R. McMackin, B. Nasseroleslami, 2022 .

C9orf72 expansion differentially affects males with spinal onset amyotrophic lateral sclerosis

A. Al-Chalabi, C. Shaw, A. Chiò, 2016, Journal of Neurology, Neurosurgery & Psychiatry.

Amyotrophic Lateral Sclerosis Incidence and Previous Prescriptions of Drugs for the Nervous System

A. Chiò, A. Calvo, G. Costa, 2016, Neuroepidemiology.

The heterozygous deletion c.1509_1510delAG in exon 14 of FUS causes an aggressive childhood-onset ALS with cognitive impairment

P. Lanteri, A. Chiò, A. Calvo, 2021, Neurobiology of Aging.

Cardiovascular diseases may play a negative role in the prognosis of amyotrophic lateral sclerosis

A. Chiò, G. Mora, G. Logroscino, 2018, European journal of neurology.

Validation of the Italian version of the Rasch-Built Overall Amyotrophic Lateral Sclerosis Disability Scale (ROADS) administered to patients and their caregivers

A. Chiò, A. Calvo, C. Moglia, 2021, Amyotrophic lateral sclerosis & frontotemporal degeneration.

Percutaneous radiological gastrostomy: a safe and effective method of nutritional tube placement in advanced ALS

A. Chiò, R. Mutani, A. Calvo, 2004, Journal of Neurology, Neurosurgery & Psychiatry.

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene in and for Therapeutic

Timothy A. Miller, Denis C. Bauer, Shankaracharya, 2018 .

NADPH oxidase 2 (NOX2) enzyme activation in patients with chronic inflammatory demyelinating polyneuropathy

A. Chiò, L. Lopiano, A. Calvo, 2016, European journal of neurology.

Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture

Sonja W. Scholz, Lilah M. Besser, Alan J. Thomas, 2021, Nature Genetics.

Whole genome sequencing analysis reveals post-zygotic mutation variability in monozygotic twins discordant for amyotrophic lateral sclerosis

A. Al-Chalabi, P. Andersen, A. Chiò, 2022, Neurobiology of Aging.

Erratum to: Brain hypermetabolism in amyotrophic lateral sclerosis: a FDG PET study in ALS of spinal and bulbar onset

A. Chiò, F. Nobili, A. Calvo, 2011, European Journal of Nuclear Medicine and Molecular Imaging.

Religiousness is positively associated with quality of life of ALS caregivers

A. Chiò, A. Calvo, A. Montuschi, 2011, Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases.

Arterial blood gas analysis: base excess and carbonate are predictive of noninvasive ventilation adaptation and survival in amyotrophic lateral sclerosis

A. Chiò, G. Mora, A. Calvo, 2021, Amyotrophic lateral sclerosis & frontotemporal degeneration.

Cardiovascular diseases may play a negative role in the prognosis of ALS

Sonia, Messina, G. Mora, 2018 .

Whole genome sequencing analysis reveals post-zygotic mutation variability in monozygotic twins discordant for amyotrophic lateral sclerosis

A. Al-Chalabi, P. Andersen, A. Chiò, 2022, Neurobiology of Aging.

A novel p.Ser108LeufsTer15 SOD1 mutation leading to the formation of a premature stop codon in an apparently sporadic ALS patient: insights into the underlying pathomechanisms

P. Andersen, A. Chiò, G. Mora, 2018, Neurobiology of Aging.

A familial ALS case carrying a novel p.G147C SOD1 heterozygous missense mutation with non-executive cognitive impairment

A. Chiò, A. Calvo, M. Valentini, 2014, Journal of Neurology, Neurosurgery & Psychiatry.

Role of brain 2-[18F]fluoro-2-deoxy-D-glucose-positron-emission tomography as survival predictor in amyotrophic lateral sclerosis

A. Giuliani, A. Chiò, A. Calvo, 2022, European Journal of Nuclear Medicine and Molecular Imaging.

Respiratory support in a population-based ALS cohort: demographic, timing and survival determinants

A. Chiò, G. Mora, A. Calvo, 2022, Journal of Neurology, Neurosurgery, and Psychiatry.

TDP-43 real-time quaking induced conversion reaction optimization and detection of seeding activity in CSF of amyotrophic lateral sclerosis and frontotemporal dementia patients

P. Manganotti, A. Chiò, A. Calvo, 2020, Brain communications.

Parkinsonian traits in amyotrophic lateral sclerosis (ALS): a prospective population-based study

A. Chiò, F. Nobili, M. Rizzone, 2019, Journal of Neurology.

Spatial epidemiology of amyotrophic lateral sclerosis in Piedmont and Aosta Valley, Italy: a population‐based cluster analysis

A. Chiò, A. Calvo, C. Moglia, 2018, European journal of neurology.

ALS in Italian professional soccer players: The risk is still present and could be soccer-specific

A. Chiò, G. Mora, R. Mutani, 2009, Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases.

Conjugal amyotrophic lateral sclerosis: suggestion for the implication of environmental factors

A. Chiò, R. Mutani, A. Calvo, 2001, Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases.

A de novo nonsense mutation of the FUS gene in an apparently familial amyotrophic lateral sclerosis case

A. Chiò, B. Traynor, A. Calvo, 2014, Neurobiology of Aging.

Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

Ewout J. N. Groen, Annelot M. Dekker, Ross P. Byrne, 2021, Nature Genetics.

Genome-wide study of DNA methylation in Amyotrophic Lateral Sclerosis identifies differentially methylated loci and implicates metabolic, inflammatory and cholesterol pathways

Annelot M. Dekker, Ahmad Al Khleifat, N. Wray, 2021, medRxiv.

Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS

Annelot M. Dekker, N. Wray, A. McRae, 2022, Science Translational Medicine.

NEK1 variants confer susceptibility to amyotrophic lateral sclerosis

Annelot M. Dekker, Robert H. Brown, F. Baas, 2016, Nature Genetics.

Exome array analysis of rare and low frequency variants in amyotrophic lateral sclerosis

Annelot M. Dekker, S. Pulit, A. Chiò, 2019, Scientific Reports.

SCFD1 expression quantitative trait loci in amyotrophic lateral sclerosis are differentially expressed

Ashley R. Jones, G. Breen, A. Al-Chalabi, 2021, Brain communications.

A novel splice site FUS mutation in a familial ALS case: effects on protein expression

A. Chiò, A. Calvo, C. Moglia, 2021, Amyotrophic lateral sclerosis & frontotemporal degeneration.

Monocytes of patients with amyotrophic lateral sclerosis linked to gene mutations display altered TDP‐43 subcellular distribution

A. Chiò, A. Calvo, M. Mostert, 2017, Neuropathology and applied neurobiology.

ALS mutant FUS proteins are recruited into stress granules in induced pluripotent stem cell-derived motoneurons

I. Bozzoni, A. Chiò, A. Calvo, 2015, Disease Models & Mechanisms.

FUS mutations in sporadic amyotrophic lateral sclerosis

D. Stephan, M. Cookson, T. Dunckley, 2011, Neurobiology of Aging.

A de novo missense mutation of the FUS gene in a “true” sporadic ALS case

A. Chiò, B. Traynor, A. Calvo, 2011, Neurobiology of Aging.

Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS

Patrizia Sola, Joanne Wuu, Michael Benatar, 2011, Neuron.

Genetic correlation between amyotrophic lateral sclerosis and schizophrenia

Denis C. Bauer, Annelot M. Dekker, Ashley R. Jones, 2017, Nature Communications.

Mice with endogenous TDP‐43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis

Eric T. Wang, Nicolas L. Fawzi, E. Wang, 2018, The EMBO journal.

Trauma and amyotrophic lateral sclerosis: a case–control study from a population‐based registry

E. Beghi, A. Chiò, G. Logroscino, 2012, European journal of neurology.

Analysis of amyotrophic lateral sclerosis as a multistep process: a population-based modelling study

N. Pearce, A. Al-Chalabi, C. Shaw, 2014, The Lancet Neurology.

Kinesin-associated protein 3 (KIFAP3) has no effect on survival in a population-based cohort of ALS patients

Janel O. Johnson, D. Hernandez, M. Nalls, 2010, Proceedings of the National Academy of Sciences.

Analysis of the GCG repeat length in NIPA1 gene in C9orf72-mediated ALS in a large Italian ALS cohort

A. Chiò, A. Calvo, C. Moglia, 2019, Neurological Sciences.

Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

Ewout J. N. Groen, Annelot M. Dekker, Ross P. Byrne, 2021, Nature Genetics.

Large proportion of amyotrophic lateral sclerosis cases in Sardinia due to a single founder mutation of the TARDBP gene.

Janel O. Johnson, D. Hernandez, M. Nalls, 2011, Archives of neurology.

A Distinct MR Imaging Phenotype in Amyotrophic Lateral Sclerosis: Correlation between T1 Magnetization Transfer Contrast Hyperintensity along the Corticospinal Tract and Diffusion Tensor Imaging Analysis

A. Chiò, A. Calvo, M. Valentini, 2012, American Journal of Neuroradiology.

Defective cyclophilin A induces TDP-43 proteinopathy: implications for amyotrophic lateral sclerosis and frontotemporal dementia

A. Chiò, G. Mora, B. Traynor, 2020, bioRxiv.

Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study

Janel O. Johnson, D. Hernandez, M. Nalls, 2012, The Lancet Neurology.

Metabolic spatial connectivity in amyotrophic lateral sclerosis as revealed by independent component analysis

Adriano Chiò, Flavio Nobili, Angelina Cistaro, 2016, Human brain mapping.

Neuroimaging in amyotrophic lateral sclerosis: insights into structural and functional changes

M. Filippi, A. Chiò, F. Agosta, 2014, The Lancet Neurology.

Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis

Lorne Zinman, Adriano Chiò, Richard W. Orrell, 2014, Nature Neuroscience.

SOMAscan Proteomics Identifies Novel Plasma Proteins in Amyotrophic Lateral Sclerosis Patients

A. Chiò, A. Calvo, G. Chiorino, 2023, International journal of molecular sciences.

Neuropathology of Olfactory Ensheathing Cell Transplantation into the Brain of Two Amyotrophic Lateral Sclerosis (ALS) Patients

A. Chiò, A. Calvo, M. Giordana, 2009, Brain pathology.

Epidemiology of ALS in Italy

A. Chiò, G. Mora, R. Mutani, 2009, Neurology.

18F-FDG-PET correlates of cognitive impairment in ALS

A. Chiò, A. Calvo, A. Montuschi, 2016, Neurology.

Factors predicting disease progression in C9ORF72 ALS patients

M. Vinceti, A. Chiò, A. Calvo, 2022, Journal of Neurology.

Developments in the assessment of non-motor disease progression in amyotrophic lateral sclerosis

A. Chiò, G. Mora, A. Calvo, 2021, Expert review of neurotherapeutics.

Comorbidity between CIDP and diabetes mellitus: only a matter of chance?

A. Chiò, R. Mutani, A. Calvo, 2009, European journal of neurology.

Markers of blood-brain barrier disruption increase early and persistently in COVID-19 patients with neurological manifestations

A. Calvo, N. Stocchetti, A. Nobili, 2022, Frontiers in Immunology.

Common polymorphisms of chemokine (C‐X3‐C motif) receptor 1 gene modify amyotrophic lateral sclerosis outcome: A population‐based study

A. Chiò, G. Mora, B. Traynor, 2018, Muscle & nerve.

The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease

D. Rujescu, H. Hakonarson, U. Lindenberger, 2015, Alzheimer's & Dementia.

The metabolic signature of C9ORF72-related ALS: FDG PET comparison with nonmutated patients

A. Chiò, B. Traynor, F. Nobili, 2014, European Journal of Nuclear Medicine and Molecular Imaging.

Exploiting mutual information for the imputation of static and dynamic mixed-type clinical data with an adaptive k-nearest neighbours approach

Adriano Chiò, Barbara Di Camillo, Rosario Vasta, 2020, BMC Medical Informatics and Decision Making.

Safety and efficacy of nabiximols on spasticity symptoms in patients with motor neuron disease (CANALS): a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial

L. Pozzi, L. Leocani, A. Chiò, 2019, The Lancet Neurology.

Specialist palliative care improves the quality of life in advanced neurodegenerative disorders: NE-PAL, a pilot randomised controlled study

A. Chiò, A. Calvo, P. Cavalla, 2015, BMJ Supportive & Palliative Care.

Testing the diagnostic accuracy of [18F]FDG-PET in discriminating spinal- and bulbar-onset amyotrophic lateral sclerosis

D. Perani, A. Chiò, A. Calvo, 2019, European Journal of Nuclear Medicine and Molecular Imaging.

The interplay among education, brain metabolism, and cognitive impairment suggests a role of cognitive reserve in Amyotrophic Lateral Sclerosis

A. Chiò, A. Calvo, C. Moglia, 2020, Neurobiology of Aging.

Interplay between spinal cord and cerebral cortex metabolism in amyotrophic lateral sclerosis

Alessandro Bellini, Gianmario Sambuceti, Michele Piana, 2018, Brain : a journal of neurology.

A PET/CT approach to spinal cord metabolism in amyotrophic lateral sclerosis

Gianmario Sambuceti, Michele Piana, Annalisa Perasso, 2016, European Journal of Nuclear Medicine and Molecular Imaging.

Neurobehavioral symptoms in ALS are negatively related to caregivers’ burden and quality of life

A. Chiò, A. Calvo, A. Vignola, 2010, European journal of neurology.

Amyotrophic lateral sclerosis among the migrant population to Piemonte, northwestern Italy

A. Chiò, A. Calvo, C. Magnani, 1999, Journal of Neurology.

Decreased Levels of Foldase and Chaperone Proteins Are Associated with an Early-Onset Amyotrophic Lateral Sclerosis

E. Beghi, A. Chiò, A. Calvo, 2017, Front. Mol. Neurosci..

Broadening the clinical spectrum of FUS mutations: a case with monomelic amyotrophy with a late progression to amyotrophic lateral sclerosis

A. Chiò, A. Calvo, C. Moglia, 2020, Neurological Sciences.

Decline of cognitive and behavioral functions in amyotrophic lateral sclerosis: a longitudinal study

A. Chiò, A. Calvo, A. Facchin, 2020, Amyotrophic lateral sclerosis & frontotemporal degeneration.

ALS clinical trials

A. Chiò, G. Mora, A. Calvo, 2011, Neurology.

The IVS1 +319 t>a of SOD1 gene is not an ALS causing mutation

A. Chiò, R. Mutani, A. Calvo, 2005 .

Causal associations of genetic factors with clinical progression in amyotrophic lateral sclerosis

M. Jahed-Motlagh, B. Minaei-Bidgoli, A. Chiò, 2022, Comput. Methods Programs Biomed..

Lithium carbonate in amyotrophic lateral sclerosis

E. Beghi, G. Logroscino, A. Chiò, 2010, Neurology.

OP-BRCM200142 1..14

P. Manganotti, A. Chiò, A. Calvo, 2020 .

Valosin-containing protein (VCP) mutations in sporadic amyotrophic lateral sclerosis

Sonja W. Scholz, Janel O. Johnson, A. Chiò, 2012, Neurobiology of Aging.

Clinical characteristics of patients with familial amyotrophic lateral sclerosis carrying the pathogenic GGGGCC hexanucleotide repeat expansion of C9ORF72.

F. Marrosu, A. Chiò, G. Mora, 2012, Brain : a journal of neurology.

A20 in Multiple Sclerosis and Parkinson’s Disease: Clue to a Common Dysregulation of Anti-Inflammatory Pathways?

A. Chiò, A. Calvo, G. Fuda, 2017, Neurotoxicity Research.

Cognitive screening in patients with amyotrophic lateral sclerosis in early stages

A. Chiò, A. Calvo, A. Cannas, 2012, Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases.

Correlation between Apolipoprotein E genotype and brain metabolism in amyotrophic lateral sclerosis

A. Chiò, A. Calvo, C. Moglia, 2018, European journal of neurology.

Effect of RNS60 in amyotrophic lateral sclerosis: a phase II multicentre, randomized, double‐blind, placebo‐controlled trial

S. Paganoni, E. Beghi, G. Logroscino, 2022, European journal of neurology.

Amyotrophic lateral sclerosis outcome measures and the role of albumin and creatinine: a population-based study.

A. Chiò, G. Mora, A. Calvo, 2014, JAMA neurology.

Italian adaptation of the Beaumont Behavioral Inventory (BBI): psychometric properties and clinical usability

A. Chiò, G. Mora, A. Calvo, 2021, Amyotrophic lateral sclerosis & frontotemporal degeneration.

Metabolic brain changes across different levels of cognitive impairment in ALS: a 18F-FDG-PET study

A. Chiò, A. Calvo, C. Moglia, 2020, Journal of Neurology, Neurosurgery, and Psychiatry.

Pathogenic VCP Mutations Induce Mitochondrial Uncoupling and Reduced ATP Levels

Nick C Fox, Colin J. Mahoney, J. Hardy, 2013, Neuron.

The Italian multicenter experience with edaravone in amyotrophic lateral sclerosis

M. Filippi, A. Calvo, R. Dubbioso, 2020, Journal of Neurology.

Erythropoietin in amyotrophic lateral sclerosis: a multicentre, randomised, double blind, placebo controlled, phase III study

E. Granieri, A. Chiò, G. Mora, 2015, Journal of Neurology, Neurosurgery & Psychiatry.

Serum chloride as a respiratory failure marker in amyotrophic lateral sclerosis

A. Chiò, A. Calvo, C. Moglia, 2023, Frontiers in Aging Neuroscience.

UNC13A influences survival in Italian amyotrophic lateral sclerosis patients: a population-based study

L. Ferrucci, A. Chiò, G. Mora, 2013, Neurobiology of Aging.

ATXN2 polyQ intermediate repeats are a modifier of ALS survival

A. Chiò, G. Mora, A. Calvo, 2015, Neurology.

A longitudinal study defined circulating microRNAs as reliable biomarkers for disease prognosis and progression in ALS human patients

A. Musarò, I. Bozzoni, A. Chiò, 2021, Cell death discovery.

Differential Neuropsychological Profile of Patients With Amyotrophic Lateral Sclerosis With and Without C9orf72 Mutation

A. Chiò, A. Calvo, C. Moglia, 2020, Neurology.

The Role of APOE in the Occurrence of Frontotemporal Dementia in Amyotrophic Lateral Sclerosis.

A. Chiò, A. Calvo, A. Montuschi, 2016, JAMA neurology.

HFE p.H63D polymorphism does not influence ALS phenotype and survival

Janel O. Johnson, M. Nalls, A. Chiò, 2015, Neurobiology of Aging.

Prevalence of SOD1 mutations in the Italian ALS population

A. Chiò, B. Traynor, R. Mutani, 2008, Neurology.

Neck flexor weakness at diagnosis predicts respiratory impairment in amyotrophic lateral sclerosis

A. Chiò, A. Calvo, C. Moglia, 2020, European journal of neurology.

Telemedicine for patients with amyotrophic lateral sclerosis during COVID-19 pandemic: an Italian ALS referral center experience

A. Chiò, A. Calvo, C. Moglia, 2020, Amyotrophic lateral sclerosis & frontotemporal degeneration.

Stapedial Reflex: A Possible Novel Biomarker of Early Bulbar Involvement in Amyotrophic Lateral Sclerosis Patients

A. Chiò, A. Calvo, A. Albera, 2021, Audiology and Neurotology.

C9orf72 ALS mutation carriers show extensive cortical and subcortical damage compared to matched wild-type ALS patients

A. Chiò, F. Agosta, A. Calvo, 2023, NeuroImage: Clinical.

Regional spreading of symptoms at diagnosis as a prognostic marker in amyotrophic lateral sclerosis: a population-based study

A. Chiò, G. Mora, A. Calvo, 2019, Journal of Neurology, Neurosurgery, and Psychiatry.

Caregiver burden and patients’ perception of being a burden in ALS

A. Chiò, R. Mutani, A. Calvo, 2005, Neurology.

Anxiety undermines quality of life in ALS patients and caregivers

A. Chiò, A. Calvo, A. Vignola, 2008, European journal of neurology.

A Dynamic Bayesian Network model for simulation of disease progression in Amyotrophic Lateral Sclerosis patients

Barbara Di Camillo, Andrea Calvo, Adriano Chiò, 2017, PeerJ Prepr..

Resting state functional connectivity alterations in primary lateral sclerosis

M. Filippi, A. Falini, A. Chiò, 2014, Neurobiology of Aging.

Multicentre, cross-cultural, population-based, case–control study of physical activity as risk factor for amyotrophic lateral sclerosis

R. Vermeulen, E. Beghi, A. Chiò, 2018, Journal of Neurology, Neurosurgery, and Psychiatry.

The palliative care needs of people severely affected by neurodegenerative disorders: A qualitative study

A. Chiò, A. Calvo, S. Veronese, 2015 .

Predicting functional impairment trajectories in amyotrophic lateral sclerosis: a probabilistic, multifactorial model of disease progression

R. Rinaldi, B. Di Camillo, M. Vinceti, 2022, Journal of Neurology.

Clinical features and outcomes of the flail arm and flail leg and pure lower motor neuron MND variants: a multicentre Italian study

L. Pozzi, M. Filippi, A. Chiò, 2020, Journal of Neurology, Neurosurgery, and Psychiatry.

Comorbidity of dementia with amyotrophic lateral sclerosis (ALS): insights from a large multicenter Italian cohort

A. Chiò, G. Mora, G. Logroscino, 2017, Journal of Neurology.

Clinical features and outcomes of the flail arm and flail leg and pure lower motor neuron MND variants: a multicenter Italian study

Messina, Lunetta, L. Pozzi, 2020 .

Non-Invasive Mechanical Ventilation reduces the Motor Decline in Amyotrophic Lateral Sclerosis

A. Chiò, G. Mora, A. Calvo, 2023, medRxiv.

Amyotrophic lateral sclerosis regional progression intervals change according to time of involvement of different body regions

A. Chiò, G. Mora, A. Calvo, 2023, European journal of neurology.

Brain metabolic differences between pure bulbar and pure spinal ALS: a 2-[18F]FDG-PET study

A. Giuliani, A. Chiò, A. Calvo, 2022, Journal of Neurology.

Brain metabolic changes across King’s stages in amyotrophic lateral sclerosis: a 18F-2-fluoro-2-deoxy-d-glucose-positron emission tomography study

A. Chiò, P. van Damme, K. Van Laere, 2020, European Journal of Nuclear Medicine and Molecular Imaging.

Validation of the Italian version of self-administered ALSFRS-R scale

A. Chiò, A. Calvo, C. Moglia, 2020, Amyotrophic lateral sclerosis & frontotemporal degeneration.

Association of Copresence of Pathogenic Variants Related to Amyotrophic Lateral Sclerosis and Prognosis

A. Chiò, G. Mora, B. Traynor, 2023, Neurology.

Clinical and Metabolic Signature of UNC13A rs12608932 Variant in Amyotrophic Lateral Sclerosis

Sonja W. Scholz, A. Chiò, B. Traynor, 2022, Neurology: Genetics.

Validation of the revised classification of cognitive and behavioural impairment in ALS

A. Chiò, G. Mora, A. Calvo, 2019, Journal of Neurology, Neurosurgery, and Psychiatry.

Influence of arterial hypertension, type 2 diabetes and cardiovascular risk factors on ALS outcome: a population-based study

A. Chiò, G. Mora, A. Calvo, 2017, Amyotrophic lateral sclerosis & frontotemporal degeneration.

Identifying and predicting amyotrophic lateral sclerosis clinical subgroups: a population-based machine-learning study.

M. Nalls, Anant Dadu, F. Faghri, 2022, The Lancet. Digital health.

Identification and prediction of ALS subgroups using machine learning

M. Nalls, R. Campbell, Anant Dadu, 2021, medRxiv.

Mutational Analysis of Known ALS Genes in an Italian Population-Based Cohort

Sonja W. Scholz, A. Chiò, B. Traynor, 2020, Neurology.

The p.A382T TARDBP gene mutation in Sardinian patients affected by Parkinson's disease and other degenerative parkinsonisms

P. Tacconi, F. Marrosu, A. Chiò, 2013, neurogenetics.

Amyotrophic lateral sclerosis mimic syndrome due to a dorsal spinal cord neurofibroma

A. Chiò, R. Mutani, A. Calvo, 2010, Neurological Sciences.

Percutaneous endoscopic gastrostomy in amyotrophic lateral sclerosis Effects on nutritional status and survival

A. Chiò, P. Onorati, A. Calvo, 1998 .

TBK1 is associated with ALS and ALS-FTD in Sardinian patients

Hannah A. Pliner, A. Mulas, F. Marrosu, 2016, Neurobiology of Aging.

Nature meets nurture in amyotrophic lateral sclerosis

A. Chiò, B. Traynor, A. Calvo, 2021, The Lancet Neurology.

GBA variants influence cognitive status in amyotrophic lateral sclerosis

A. Chiò, B. Traynor, A. Calvo, 2021, Journal of Neurology, Neurosurgery, and Psychiatry.

Theme 10 - Disease Stratification and Phenotyping of Patients

A. Chiò, A. Calvo, C. Moglia, 2022, Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration.

Genome-wide structural variant analysis identifies risk loci for non-Alzheimer’s dementias

Ryan L. Collins, Sonja W. Scholz, Toshiko Tanaka, 2023, Cell genomics.

The influence of genetic mutations on the multistep process in ALS (S4.004)

N. Pearce, A. Al-Chalabi, A. Chiò, 2018 .

Analysis of the KIFAP3 gene in amyotrophic lateral sclerosis: a multicenter survival study

Ewout J. N. Groen, D. Rujescu, S. Corti, 2014, Neurobiology of Aging.

Plasma CHI3L1 in Amyotrophic Lateral Sclerosis: A Potential Differential Diagnostic Biomarker

A. Chiò, A. Calvo, C. Moglia, 2023, Journal of clinical medicine.

Prognostic role of slow vital capacity in amyotrophic lateral sclerosis

A. Chiò, A. Calvo, C. Moglia, 2020, Journal of Neurology.

Amyotrophic lateral sclerosis associated with pregnancy: report of four new cases and review of the literature

A. Chiò, G. Mora, R. Mutani, 2003, Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases.

Amyotrophic Lateral Sclerosis OutcomeMeasures and the Role of Albumin and Creatinine A Population-Based Study

A. Chiò, G. Mora, A. Calvo, 2014 .

The HFE p.H63D (p.His63Asp) Polymorphism Is a Modifier of ALS Outcome in Italian and French Patients with SOD1 Mutations

A. Chiò, V. Meininger, G. Mora, 2023, Biomedicines.

Prospective epidemiological registers: a valuable tool for uncovering ALS pathogenesis

A. Chiò, A. Calvo, A. Canosa, 2011, Journal of Neurology, Neurosurgery & Psychiatry.

Plasma amino acids patterns and age of onset of amyotrophic lateral sclerosis

E. Beghi, A. Calvo, M. Filosto, 2014, Amyotrophic lateral sclerosis & frontotemporal degeneration.

Withdrawal of mechanical ventilation in amyotrophic lateral sclerosis patients: a multicenter Italian survey.

A. Calvo, S. Veronese, C. Moglia, 2023, Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology.

Amyotrophic lateral sclerosis onset after prolonged treatment with a VEGF receptors inhibitor

A. Chiò, A. Calvo, C. Moglia, 2015, Amyotrophic lateral sclerosis & frontotemporal degeneration.

Eye Tracking Impact on Quality-of-Life of ALS Patients

Laura Farinetti, Fulvio Corno, Andrea Calvo, 2008, ICCHP.

Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study

Janel O. Johnson, D. Hernandez, M. Nalls, 2012, The Lancet Neurology.

A novel p.E121G heterozygous missense mutation of SOD1 in an apparently sporadic ALS case with a 14-year course

A. Chiò, A. Calvo, C. Moglia, 2015, Amyotrophic lateral sclerosis & frontotemporal degeneration.

The multistep hypothesis of ALS revisited The role of genetic mutations

N. Pearce, A. Chiò, O. Hardiman, 2022 .

The multistep hypothesis of ALS revisited The role of genetic mutations

A. Chiò, O. Hardiman, R. McLaughlin, 2022 .

Amyotrophic lateral sclerosis caregiver burden and patients’ quality of life during COVID-19 pandemic

A. Chiò, A. Calvo, C. Moglia, 2021, Amyotrophic lateral sclerosis & frontotemporal degeneration.

Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study

Janel O. Johnson, D. Hernandez, G. Schellenberg, 2012, The Lancet Neurology.

Amyotrophic lateral sclerosis associated with pregnancy: report of four new cases and review of the literature

A. Chiò, G. Mora, A. Calvo, 2003 .

The role of peripheral immunity in ALS: a population‐based study

A. Chiò, A. Calvo, C. Moglia, 2022, medRxiv.

Brain 18fluorodeoxyglucose-positron emission tomography changes in amyotrophic lateral sclerosis with TARDBP mutations

A. Chiò, A. Calvo, C. Moglia, 2022, Journal of Neurology, Neurosurgery, and Psychiatry.

Cognitive Reserve in ALS with Comorbid Frontotemporal Dementia (FTD): A Population-Based Study (P5.081)

A. Chiò, L. Lopiano, A. Calvo, 2014 .

Plateaus in amyotrophic lateral sclerosis progression: results from a population‐based cohort

A. Chiò, A. Calvo, C. Moglia, 2020, European journal of neurology.

Phosphorylated TDP-43 aggregates in peripheral motor nerves of patients with amyotrophic lateral sclerosis

M. Filippi, A. Chiò, G. Logroscino, 2022, Brain : a journal of neurology.

THEME 2 GENETICS AND GENOMICS GEN-01 A case of an uncommon late onset of ALS associated with an undescribed SOD1 mutation GEN-02 A novel mutation in ZFYVE26 gene (c.195-1G > A) in a young man affected by spastic paraplegia

A. Calvo, G. Siciliano, A. Fogli, 2022 .

Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS

Sonja W. Scholz, Janel O. Johnson, D. Hernandez, 2010, Neuron.

Epidemiology of ALS in Italy

A. Chiò, G. Mora, A. Calvo, 2009, Neurology.

ALS clinical trials

A. Chiò, G. Mora, A. Calvo, 2011, Neurology.

NEK1 variants confer susceptibility to amyotrophic lateral sclerosis

Annelot M. Dekker, F. Baas, T. Meitinger, 2016, Nature Genetics.

Pain in amyotrophic lateral sclerosis: a population‐based controlled study

A. Chiò, A. Calvo, C. Moglia, 2012, European journal of neurology.

Prognosis for patients with amyotrophic lateral sclerosis: development and validation of a personalised prediction model

Annelot M. Dekker, A. Al-Chalabi, C. Shaw, 2018, The Lancet Neurology.

Repeated courses of granulocyte colony‐stimulating factor in amyotrophic lateral sclerosis: Clinical and biological results from a prospective multicenter study

A. Chiò, G. Mora, S. Rutella, 2011, Muscle & nerve.

ATXN2 is a modifier of phenotype in ALS patients of Sardinian ancestry

M. Nalls, F. Marrosu, A. Chiò, 2015, Neurobiology of Aging.

Influence of cigarette smoking on ALS outcome: a population-based study

A. Chiò, G. Mora, A. Calvo, 2016, Journal of Neurology, Neurosurgery & Psychiatry.

Presymptomatic geographical distribution of ALS patients suggests the involvement of environmental factors in the disease pathogenesis

A. Chiò, A. Calvo, C. Moglia, 2023, Journal of Neurology.

Theme 02 - Genetics and Genomics

A. Calvo, G. Siciliano, A. Fogli, 2022, Amyotrophic lateral sclerosis & frontotemporal degeneration.

Do ecological factors influence the clinical presentation of amyotrophic lateral sclerosis?

A. Chiò, A. Calvo, C. Moglia, 2021, Journal of the Neurological Sciences.

Public Policy in ALS Care: The Italian Situation

A. Calvo, S. Veronese, 2020 .

Theme 08 - CLINICAL IMAGING AND ELECTROPHYSIOLOGY

T. Williams, A. Calvo, R. McMackin, 2021, Amyotrophic lateral sclerosis & frontotemporal degeneration.

Amyotrophic Lateral Sclerosis Incidence and Previous Prescriptions of Drugs for the Nervous System

A. Chiò, A. Calvo, G. Costa, 2016, Neuroepidemiology.

Predictors for progression in amyotrophic lateral sclerosis associated to SOD1 mutation: insight from two population-based registries

M. Vinceti, A. Chiò, A. Calvo, 2023, Journal of Neurology.

Genetic architecture of ALS in Sardinia

Hannah A. Pliner, M. Nalls, F. Marrosu, 2014, Neurobiology of Aging.

A patient carrying a homozygous p.A382T TARDBP missense mutation shows a syndrome including ALS, extrapyramidal symptoms, and FTD

A. Chiò, B. Traynor, A. Calvo, 2011, Neurobiology of Aging.

Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

Annelot M. Dekker, Raymond D. Schellevis, Ashley R. Jones, 2016, Nature Genetics.

Whole genome sequencing analysis reveals post-zygotic mutation variability in monozygotic twins discordant for amyotrophic lateral sclerosis

A. Al-Chalabi, P. Andersen, A. Chiò, 2022, Neurobiology of Aging.

Neurobiology of Aging

J. Veldink, A. Calvo, C. Moglia, 2022 .

Safety and efficacy of ozanezumab in patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled, phase 2 trial

Annelot M. Dekker, A. Destée, S. Bates, 2017, The Lancet Neurology.

Shared and Unique Disease Pathways in Amyotrophic Lateral Sclerosis and Parkinson’s Disease Unveiled in Peripheral Blood Mononuclear Cells

M. Rizzone, L. Lopiano, A. Calvo, 2023, ACS chemical neuroscience.