J. Hofsteenge

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Direct determination of glycosylation sites in O-fucosylated glycopeptides using nano-electrospray quadrupole time-of-flight mass spectrometry.

B. Maček, J. Hofsteenge, J. Peter-Katalinic, 2001, Rapid communications in mass spectrometry : RCM.

Mitogen-activated 70K S6 kinase. Identification of in vitro 40 S ribosomal S6 phosphorylation sites.

J. Hofsteenge, S. Ferrari, G. Thomas, 1991, The Journal of biological chemistry.

Correct folding of circularly permuted variants of a beta alpha barrel enzyme in vivo.

K. Luger, J. Hofsteenge, K. Kirschner, 1989, Science.

Recognition signal for C-mannosylation of Trp-7 in RNase 2 consists of sequence Trp-x-x-Trp.

J. Hofsteenge, D. Hess, J. Krieg, 1998, Molecular biology of the cell.

Posttranslational Processing of a New Class of Hydroxyproline-Containing Proteins (Prolyl Hydroxylation and C-Terminal Cleavage of Tobacco (Nicotiana tabacum) Vacuolar Chitinase)

T. Boller, J. Hofsteenge, J. Neuhaus, 1993, Plant physiology.

Interaction of the N-terminal region of hirudin with the active-site cleft of thrombin.

J. Hofsteenge, A. Betz, S. Stone, 1992, Biochemistry.

Mechanistic studies on thrombin catalysis.

J. Hofsteenge, A. Betz, S. Stone, 1991, Biochemistry.

The repressor MDBP-2 is a member of the histone H1 family that binds preferentially in vitro and in vivo to methylated nonspecific DNA sequences.

J. Hofsteenge, J. Jost, 1992, Proceedings of the National Academy of Sciences of the United States of America.

The RNA moiety of chick embryo 5-methylcytosine- DNA glycosylase targets DNA demethylation.

M. Siegmann, J. Hofsteenge, J. Jost, 1997, Nucleic acids research.

Vacuolar chitinases of tobacco: a new class of hydroxyproline-containing proteins.

J. Hofsteenge, J. Neuhaus, F. Meins, 1992, Science.

C-Mannosylation of Human RNase 2 Is an Intracellular Process Performed by a Variety of Cultured Cells*

J. Hofsteenge, D. Hess, J. Krieg, 1997, The Journal of Biological Chemistry.

Ribonuclease 4, an evolutionarily highly conserved member of the superfamily

J. Hofsteenge, A. Vicentini, O. Zelenko, 1998, Cellular and Molecular Life Sciences CMLS.

Residues 36‐42 of liver RNase PL3 contribute to its uridine‐preferring substrate specificity. Cloning of the cDNA and site‐directed mutagenesis studies

J. Hofsteenge, B. Hemmings, A. Vicentini, 1994, Protein science : a publication of the Protein Society.

Spectroscopic and protein chemical analyses demonstrate the presence of C-mannosylated tryptophan in intact human RNase 2 and its isoforms.

J. Hofsteenge, D. Hess, M. Meldal, 1996, Biochemistry.

Effect of heparin on the glia-derived-nexin-thrombin interaction.

J. Hofsteenge, G. Rovelli, S. Stone, 1989, The Biochemical journal.

Quantitative Determination of Proteins in Crude Extracts

J. Hofsteenge, 1991 .

Structure of human POFUT2: insights into thrombospondin type 1 repeat fold and O‐fucosylation

J. Hofsteenge, D. Hess, H. Gut, 2012, The EMBO journal.

Peters Plus Syndrome Is a New Congenital Disorder of Glycosylation and Involves Defective O-Glycosylation of Thrombospondin Type 1 Repeats*

R. Hennekam, J. Hofsteenge, D. Hess, 2008, Journal of Biological Chemistry.

Structure and expression of a 72-kDa regulatory subunit of protein phosphatase 2A. Evidence for different size forms produced by alternative splicing.

J. Hofsteenge, W. Merlevede, J. Goris, 1993, The Journal of biological chemistry.

Stat5a Serine Phosphorylation SERINE 779 IS CONSTITUTIVELY PHOSPHORYLATED IN THE MAMMARY GLAND, AND SERINE 725 PHOSPHORYLATION INFLUENCES PROLACTIN-STIMULATED IN VITRO DNA BINDING ACTIVITY*

B. Groner, J. Hofsteenge, N. Hynes, 2000 .

New type of linkage between a carbohydrate and a protein: C-glycosylation of a specific tryptophan residue in human RNase Us.

J F Vliegenthart, J. Hofsteenge, J. Vliegenthart, 1994, Biochemistry.

Quantitative gas chromatography/mass spectrometry determination of C-mannosylation of tryptophan residues in glycoproteins.

G. Huet, J. Hofsteenge, P. Trinel, 2004, Analytical biochemistry.

Protein C-glycosylation

J. Hofsteenge, J. Vliegenthart, W. Richter, 1996 .

The hexopyranosyl residue that is C-glycosidically linked to the side chain of tryptophan-7 in human RNase Us is alpha-mannopyranose.

J. Hofsteenge, J. Vliegenthart, T. de Beer, 1995, Biochemistry.

Studies on the interaction of ribonuclease inhibitor with pancreatic ribonuclease involving differential labeling of cysteinyl residues.

J. Hofsteenge, C. Servis, S. Stone, 1991, The Journal of biological chemistry.

Analysis of subunit isoforms in protein phosphatase 2A holoenzymes from rabbit and Xenopus.

J. Hofsteenge, W. Merlevede, J. Goris, 1993, The Journal of biological chemistry.

Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform.

J. Hofsteenge, W. Merlevede, J. Goris, 1991, Biochemistry.

Role of interactions involving C-terminal nonpolar residues of hirudin in the formation of the thrombin-hirudin complex.

J. Hofsteenge, A. Betz, S. Stone, 1991, Biochemistry.

Evidence for N- and C-terminal processing of a plant defense-related enzyme: Primary structure of tobacco prepro-beta-1,3-glucanase.

J. Hofsteenge, G. Felix, J. Neuhaus, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Oxidation of Sulfhydryl Groups of Ribonuclease Inhibitor in Epithelial Cells Is Sufficient for Its Intracellular Degradation*

J. Hofsteenge, J. Fominaya, Montserrat Blázquez, 1996, The Journal of Biological Chemistry.

Evidence for common structural changes in thrombin induced by active-site or exosite binding.

J. Hofsteenge, S. Stone, M. Parry, 1993, The Biochemical journal.

cDNA sequence coding for a rat glia-derived nexin and its homology to members of the serpin superfamily.

J. Hofsteenge, S. Gloor, G. Rovelli, 1987, Biochemistry.

Enzymic and structural studies on processed proteins from the vacuolar (lutoid-body) fraction of latex of Hevea brasiliensis

J. Hofsteenge, P. Jekel, J. Schuringa, 2001 .

The use of sequence-specific antibodies to identify a secondary binding site in thrombin.

J. Hofsteenge, G. Rovelli, S. Stone, 1988, The Journal of biological chemistry.

Interaction of semisynthetic variants of RNase A with ribonuclease inhibitor

J. Hofsteenge, U. Neumann, 1994, Protein science : a publication of the Protein Society.

'Holy' proteins. I: Ribonuclease inhibitor.

J. Hofsteenge, 1994, Current opinion in structural biology.

Crystallization of porcine liver ribonuclease inhibitor a member of the family of proteins containing leucine-rich repeats.

J. Hofsteenge, B. Dijkstra, U. Neumann, 1993, Journal of molecular biology.

Inactivation of ribonuclease inhibitor by thiol-disulfide exchange.

J. Hofsteenge, J. Fominaya, 1992, The Journal of biological chemistry.

Purification and characterization of truncated ribonuclease inhibitor.

J. Hofsteenge, A. Vincentini, S. Stone, 1991, The Biochemical journal.

The effect of substituting phosphotyrosine for sulphotyrosine on the activity of hirudin.

J. Hofsteenge, L. Pinna, S. Stone, 1990, European journal of biochemistry.

cDNA cloning of porcine brain prolyl endopeptidase and identification of the active-site seryl residue.

J. Hofsteenge, B. Hemmings, S. Stone, 1991, Biochemistry.

Purification and characterization of a soluble beta-fructofuranosidase from Daucus carota.

J. Hofsteenge, A. Sturm, C. Unger, 1992, European journal of biochemistry.

The nucleotide sequence of the cDNA encoding the human lung protein phosphatase 2A beta catalytic subunit.

J. Hofsteenge, W. Wernet, B. Hemmings, 1988, Nucleic acids research.

Ribonucleases from rat and bovine liver: purification, specificity and structural characterization.

Z. Kote-Jarai, J. Hofsteenge, J. Beintema, 1998, Biochimica et biophysica acta.

Demonstration by mass spectrometry that pseudo-hevein and hevein have ragged C-terminal sequences.

J. Hofsteenge, A. Bruins, C. Jeronimus-Stratingh, 1994, Biochimica et biophysica acta.

Functional sites of glia-derived nexin (GDN): importance of the site reacting with the protease.

J. Hofsteenge, E. Shaw, G. Rovelli, 1990, Biochemistry.

Glial-derived neurite-promoting factor is a slow-binding inhibitor of trypsin, thrombin, and urokinase.

J. Hofsteenge, S. Stone, D. Monard, 1987, Archives of biochemistry and biophysics.

Enzymatic properties of proteolytic derivatives of human alpha-thrombin.

J. Hofsteenge, P. Braun, S. Stone, 1988, Biochemistry.

Identification of regions of alpha-thrombin involved in its interaction with hirudin.

J. Hofsteenge, P. Braun, S. Stone, 1987, Biochemistry.

Primary and tertiary structure studies of p-hydroxybenzoate hydroxylase from Pseudomonas fluorescens. Isolation and alignment of the CNBr peptides; interactions of the protein with flavin adenine dinucleotide.

J. Drenth, J. Hofsteenge, R. Wierenga, 2005, European journal of biochemistry.

Carrier-linked primaquine in the chemotherapy of malaria.

J. Hofsteenge, R. Altszuler, A. Capuano, 1986, Journal of medicinal chemistry.

Inactivation of prolyl endopeptidase by a peptidylchloromethane. Kinetics of inactivation and identification of sites of modification.

J. Hofsteenge, E. Shaw, P. Wikstrom, 1991, The Biochemical journal.

p‐Hyroxybenzoate Hydroxylase from Pseudomonas fluorescens: 1. Complection of the Elucidation of the Primary Structure

J. Hofsteenge, P. Jekel, J. Beintema, 1983 .

Tenascin: cDNA cloning and induction by TGF‐beta.

Shigeki, J. Hofsteenge, S. Shibahara, 1988, The EMBO journal.

pH dependence of the interaction of hirudin with thrombin.

J. Hofsteenge, A. Betz, S. Stone, 1992, Biochemistry.

Effect of heparin on the interaction between thrombin and hirudin.

J. Hofsteenge, S. Stone, 1987, European journal of biochemistry.

Specificity of activated human protein C.

J. Hofsteenge, S. Stone, 1985, The Biochemical journal.

Kinetics of the inhibition of thrombin by hirudin.

J. Hofsteenge, S. Stone, 1986, Biochemistry.

The refined 1.9 A crystal structure of human alpha‐thrombin: interaction with D‐Phe‐Pro‐Arg chloromethylketone and significance of the Tyr‐Pro‐Pro‐Trp insertion segment.

R. Huber, U. Baumann, J. Hofsteenge, 1989, The EMBO journal.

Preparation and characterization of proteolyzed forms of human α-thrombin

J. Hofsteenge, P. Braun, Jui-Yoa Chang, 1988 .

p‐Hydroxybenzoate Hydroxylase from Pseudomonas fluorescens

J. Drenth, J. Hofsteenge, R. Wierenga, 1983 .

The amino-acid sequence of the three smallest CNBr peptides from p-hydroxybenzoate hydroxylase from Pseudomonas fluorescens.

J. Hofsteenge, J. Vereijken, J. Beintema, 2005, European journal of biochemistry.

The amino acid sequence of iguana (Iguana iguana) pancreatic ribonuclease.

J. Hofsteenge, J. Beintema, W. Zhao, 1994, European journal of biochemistry.

Guinea-pig pancreatic ribonucleases. Isolation, properties, primary structure and glycosidation.

J. Hofsteenge, W. Gaastra, J. Beintema, 1977, European journal of biochemistry.

Amino acid sequence of the nonsecretory ribonuclease of human urine.

G. Schieven, J. Hofsteenge, J. Beintema, 1988, Biochemistry.

19 – Ribonuclease Inhibitor

J. Hofsteenge, 1997 .

Protein C-mannosylation is enzyme-catalysed and uses dolichyl-phosphate-mannose as a precursor.

J. Hofsteenge, D. Hess, R. Cacan, 1998, Molecular biology of the cell.

Contribution of the N-terminal region of hirudin to its interaction with thrombin.

J. Hofsteenge, S. Stone, A. Wallace, 1989, Biochemistry.

Structural studies on protein O-fucosylation by electron capture dissociation

B. Maček, J. Hofsteenge, J. Peter-Katalinic, 2004 .

Molecular basis for the inhibition of thrombin by hirudin.

J. Hofsteenge, A. Betz, S. Stone, 1993, Advances in experimental medicine and biology.

Basis for the reduced affinity of beta T- and gamma T-thrombin for hirudin.

J. Hofsteenge, S. Stone, 1991, Biochemistry.

Use of Protein Chemistry and Molecular Biology to Determine Interaction Areas Between Proteases and their Inhibitors: The Thrombin-Hirudin Interaction as an Example

J. Hofsteenge, S. Stone, A. Wallace, 1990 .

Quantitative evaluation of the contribution of ionic interactions to the formation of the thrombin-hirudin complex.

J. Hofsteenge, S. Stone, S R Stone, 1989, Biochemistry.

Use of site-directed mutagenesis to investigate the basis for the specificity of hirudin.

J. Hofsteenge, P. Braun, S. Stone, 1988, Biochemistry.

Copine-III interacts with ErbB2 and promotes tumor cell migration

J. Hofsteenge, N. Hynes, M. Bianchi, 2010, Oncogene.

Requirement of the Lec35 gene for all known classes of monosaccharide-P-dolichol-dependent glycosyltransferase reactions in mammals.

J. Hofsteenge, M. Lehrman, M. Doucey, 2001, Molecular biology of the cell.

The patatin-like protein from the latex of Hevea brasiliensis (Hev b 7) is not a vacuolar protein.

J. Hofsteenge, P. Jekel, J. Beintema, 2003, Phytochemistry.

Interaction of hirudin with the dysthrombins Quick I and II.

J. Hofsteenge, J. Dodt, S. Stone, 1991, Biochemistry.

alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure.

J. Hofsteenge, W. Merlevede, J. Goris, 1990, Biochemistry.

Molecular cloning of cDNAs encoding two isoforms of the catalytic subunit of protein phosphatase 2A.

J. Hofsteenge, B. Hemmings, S. Stone, 1987, Biochemistry.

Characterization of the Adenylation Site in the RNA 3′-Terminal Phosphate Cyclase from Escherichia coli *

W. Filipowicz, E. Billy, J. Hofsteenge, 1999, The Journal of Biological Chemistry.

Effect of thrombomodulin on the kinetics of the interaction of thrombin with substrates and inhibitors.

H. Taguchi, J. Hofsteenge, S. Stone, 1986, The Biochemical journal.

AUH, a gene encoding an AU-specific RNA binding protein with intrinsic enoyl-CoA hydratase activity.

J. Hofsteenge, P. Jenö, C. Moroni, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Identification of the 40 S ribosomal protein S6 phosphorylation sites induced by cycloheximide.

J. Hofsteenge, G. Thomas, J. Krieg, 1988, The Journal of biological chemistry.

Deficiency of Dol-P-Man synthase subunit DPM3 bridges the congenital disorders of glycosylation with the dystroglycanopathies.

J. Hofsteenge, R. Wevers, K. Verrijp, 2009, American journal of human genetics.

Protein C-mannosylation: facts and questions.

J. Hofsteenge, A. Furmanek, Aleksandra Furmanek, 2000, Acta biochimica Polonica.

Properdin, the Positive Regulator of Complement, Is HighlyC-Mannosylated*

J. Hofsteenge, S. Hartmann, 2000, The Journal of Biological Chemistry.

Protein chemical and kinetic characterization of recombinant porcine ribonuclease inhibitor expressed in Saccharomyces cerevisiae.

J. Hofsteenge, B. Hemmings, B. Kieffer, 1990, Biochemistry.

Amino acid sequence of the ribonuclease inhibitor from porcine liver reveals the presence of leucine-rich repeats.

J. Hofsteenge, B. Hemmings, B. Kieffer, 1988, Biochemistry.

Identification of Tyrosine Phosphorylation Sites on 3-Phosphoinositide-dependent Protein Kinase-1 and Their Role in Regulating Kinase Activity*

J. Hofsteenge, B. Hemmings, D. Hess, 2001, The Journal of Biological Chemistry.

NKG2D ligand expression in AML increases in response to HDAC inhibitor valproic acid and contributes to allorecognition by NK-cell lines with single KIR-HLA class I specificities.

Alois Gratwohl, W. Wiktor-Jedrzejczak, J. Hofsteenge, 2008, Blood.

The Four Terminal Components of the Complement System AreC-Mannosylated on Multiple Tryptophan Residues*

J. Hofsteenge, D. Hess, M. Blommers, 1999, The Journal of Biological Chemistry.

Crystal structure of the thrombin‐hirudin complex: a novel mode of serine protease inhibition.

W. Bode, J. Hofsteenge, W. Bode, 1990, The EMBO journal.

The effect of thrombomodulin on the cleavage of fibrinogen and fibrinogen fragments by thrombin.

J. Hofsteenge, S. Stone, 1987, European journal of biochemistry.

Caveolin-1 interacts with the chaperone complex TCP-1 and modulates its protein folding activity

J. Hofsteenge, D. Hess, M. Doucey, 2006, Cellular and Molecular Life Sciences CMLS.

Substrate specificity and antifungal activity of recombinant tobacco class I chitinases

J. Hofsteenge, F. Meins, C. Staehelin, 2001, Plant Molecular Biology.

Invariant features of the structure of pancreatic ribonuclease. A test of different predictive models.

J. Lenstra, J. Hofsteenge, J. Beintema, 1977, Journal of molecular biology.

The primary structure of pancreatic ribonuclease from mole rat superspecies Spalax leucodon.

E. Nevo, J. Hofsteenge, J. Beintema, 1993, Molecular phylogenetics and evolution.

Purification and cDNA cloning of a transcription factor which functionally cooperates within a cAMP regulatory unit in the porcine uPA gene.

J. Hofsteenge, Y. Nagamine, J Hofsteenge, 1993, Nucleic acids research.

Use of fragments of hirudin to investigate thrombin-hirudin interaction.

J. Hofsteenge, S. Stone, A. Wallace, 1990, European journal of biochemistry.

Identification and Characterization of aβ1,3-Glucosyltransferase That Synthesizes the Glc-β1,3-Fuc Disaccharide on Thrombospondin Type 1 Repeats*

J. Hofsteenge, Björn Hegemann, D. Hess, 2006, Journal of Biological Chemistry.

Stat5a Serine Phosphorylation

B. Groner, J. Hofsteenge, N. Hynes, 2000, The Journal of Biological Chemistry.

High-level soluble production and characterization of porcine ribonuclease inhibitor.

R. Raines, J. Hofsteenge, T. Klink, 2001, Protein expression and purification.

Primary structure of p-hydroxybenzoate hydroxylase from Pseudomonas fluorescens.

J. Hofsteenge, P. Jekel, J. Vereijken, 1982, Biochimica et biophysica acta.

Primary structure of a ribonuclease from porcine liver, a new member of the ribonuclease superfamily.

J. Hofsteenge, S. Stone, R. Matthies, 1989, Biochemistry.

p-Hydroxybenzoate hydroxylase from Pseudomonas fluorescens. 2. Fitting of the amino-acid sequence to the tertiary structure.

J. Drenth, J. Hofsteenge, R. Wierenga, 1983, European Journal of Biochemistry.

Primary structure of protein phosphatase 2A as determined by molecular cloning: implications for a protein phosphatase gene family.

J. Hofsteenge, B. Hemmings, S. Stone, 1988, Advances in experimental medicine and biology.

Prolyl Hydroxylation and C-Terminal Cleavage of Tobacco

T. Boller, J. Hofsteenge, J. Neuhaus, 2002 .

C-Mannosylation and O-Fucosylation of the Thrombospondin Type 1 Module*

B. Maček, J. Hofsteenge, J. Peter-Katalinic, 2001, The Journal of Biological Chemistry.

C-Mannosylation and O-Fucosylation of Thrombospondin Type 1 Repeats*

B. Maček, J. Hofsteenge, J. Peter-Katalinic, 2002, Molecular & Cellular Proteomics.

Recombinant human interleukin-12 is the second example of a C-mannosylated protein.

J. Hofsteenge, D. Hess, M. Blommers, 1999, Glycobiology.

Functional Expression of Human PP2Ac in Yeast Permits the Identification of Novel C-terminal and Dominant-negative Mutant Forms*

J. Hofsteenge, B. Hemmings, T. Myles, 1999, The Journal of Biological Chemistry.

Purification and primary structure of a porcine kidney non-secretory ribonuclease.

J. Hofsteenge, K. Ohgi, M. Irie, 1993, Bioscience, biotechnology and biochemistry.

The WSAWS motif is C-hexosylated in a soluble form of the erythropoietin receptor.

J. Hofsteenge, H. Rogniaux, D. Hess, 2003, Biochemistry.