J. Breed

发表

Comparison of in vivo and in vitro phosphorylation of the exocytosis-sensitive protein PP63/parafusin by differential MALDI mass spectrometric peptide mapping.

M. Kussmann, K. Hauser, R. Kissmehl, 1999, Biochemistry.

Imidazo[1,2-b]pyridazines: a potent and selective class of cyclin-dependent kinase inhibitors.

Andrew Pannifer, Richard A Norman, J. Breed, 2004, Bioorganic & medicinal chemistry letters.

Imidazo[1,2-a]pyridines: a potent and selective class of cyclin-dependent kinase inhibitors identified through structure-based hybridisation.

J. Breed, R. Pauptit, C. Minshull, 2003, Bioorganic & medicinal chemistry letters.

Landscape of activating cancer mutations in FGFR kinases and their differential responses to inhibitors in clinical use

C. Orengo, A. Breeze, P. Ashford, 2016, Oncotarget.

Novel, potent and selective anilinoquinazoline and anilinopyrimidine inhibitors of p38 MAP kinase.

John G Cumming, J. Breed, P. Jewsbury, 2004, Bioorganic & medicinal chemistry letters.

Prediction by a Neural Network of Outer Membrane P-strand Protein Topology

K. Diederichs, J. Breed, K. Zeth, 1998 .

An internal affinity‐tag for purification and crystallization of the siderophore receptor fhua, integral outer membrane protein from escherichia coli K‐12

K. Diederichs, J. Breed, A. Ferguson, 1998, Protein science : a publication of the Protein Society.

Crystal structure of MalK, the ATPase subunit of the trehalose/maltose ABC transporter of the archaeon Thermococcus litoralis

K. Diederichs, C. Vonrhein, J. Breed, 2000, The EMBO journal.

KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe

P. Kolasinska-Zwierz, J. Breed, J. Debreczeni, 2019, Nature Communications.

Conservation analysis and structure prediction of the SH2 family of phosphotyrosine binding domains

G. Barton, R. Russell, J. Breed, 1992, FEBS letters.

Structure-based design and pharmacokinetic optimization of covalent allosteric inhibitors of the mutant GTPase KRASG12C.

Doyle J Cassar, J. Breed, D. Ogg, 2020, Journal of medicinal chemistry.

Protein-ligand crystal structures can guide the design of selective inhibitors of the FGFR tyrosine kinase.

Andrew G. Leach, J. Breed, D. M. Andrews, 2012, Journal of medicinal chemistry.

MTH1 Substrate Recognition—An Example of Specific Promiscuity

J. Breed, J. Nissink, Michal Bista, 2016, PloS one.

Structure and interactions of NCAM Ig1-2-3 suggest a novel zipper mechanism for homophilic adhesion.

K. Diederichs, V. Berezin, E. Bock, 2003, Structure.

Rigidified Scaffolds for 3 Angstrom Resolution Cryo-EM of Small Therapeutic Protein Targets

T. Yeates, M. Sawaya, J. Breed, 2022, bioRxiv.

Alamethicin channels modelled by simulated annealing and molecular dynamics.

J. Breed, M. Sansom, 1994, Biochemical Society transactions.

Cathepsin C inhibitors: property optimization and identification of a clinical candidate.

R. Austin, J. Breed, J. Debreczeni, 2014, Journal of medicinal chemistry.

Structural insights into FGFR kinase isoform selectivity: diverse binding modes of AZD4547 and ponatinib in complex with FGFR1 and FGFR4.

A. Breeze, J. Breed, J. Tucker, 2014, Structure.

SAR and inhibitor complex structure determination of a novel class of potent and specific Aurora kinase inhibitors.

J. Breed, R. Pauptit, S. Green, 2006, Bioorganic & medicinal chemistry letters.

Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRASG12C.

Doyle J Cassar, Nichola L. Davies, J. Breed, 2022, Journal of medicinal chemistry.

Packing interactions of aib‐containing helices: Molecular modeling of parallel dimers of simple hydrophobic helices and of alamethicin

J. Breed, M. Sansom, I. Kerr, 1995, Biopolymers.

Inhibitors of acetyltransferase domain of N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU). Part 1: Hit to lead evaluation of a novel arylsulfonamide series.

Sameer Kawatkar, Haihong Ni, Suzanne Stokes, 2012, Bioorganic & medicinal chemistry letters.

Crystal structure of human thymidine phosphorylase in complex with a small molecule inhibitor.

S. Barry, J. Breed, R. Pauptit, 2004, Structure.

Functional, Conformational, and Molecular Modelling Studies of Voltage-Sensitivity and Selectivity of Synthetic Peptides Derived from Ion Channels

J. Breed, Y. Shai, M. Sansom, 1996 .

Discovery of a potent and selective oral inhibitor of ERK1/2 (AZD0364) that is efficacious in both monotherapy and combination therapy in models of non-small cell lung cancer (NSCLC).

J. Breed, M. Anderton, Lyman J. L. Feron, 2019, Journal of medicinal chemistry.

Structure-based design of protein tyrosine phosphatase-1B inhibitors.

Jon Read, Alexander L Breeze, A. Breeze, 2005, Bioorganic & medicinal chemistry letters.

Prevention of MKK6-dependent activation by binding to p38alpha MAP kinase.

Jon Read, Alexander L Breeze, Richard A Norman, 2005, Biochemistry.

Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange

Jing Zhang, Paulina Kolasinska-Zwierz, P. Kolasinska-Zwierz, 2017, Nature Communications.

Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival.

Graeme Walker, Lisa Wissler, Jon Read, 2016, Journal of medicinal chemistry.

N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor.

L. Otterbein, J. Breed, R. A. Norman, 2006, Journal of medicinal chemistry.

Phase Ib trial of intravenous recombinant humanized monoclonal antibody to vascular endothelial growth factor in combination with chemotherapy in patients with advanced cancer: pharmacologic and long-term safety data.

J. Breed, W. Novotny, E. Holmgren, 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Discovery of checkpoint kinase inhibitor (S)-5-(3-fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide (AZD7762) by structure-based design and optimization of thiophenecarboxamide ureas.

J. Breed, V. Oza, P. Lyne, 2012, Journal of medicinal chemistry.

Imidazoles: SAR and development of a potent class of cyclin-dependent kinase inhibitors.

J. Breed, D. M. Andrews, A. Barker, 2008, Bioorganic & medicinal chemistry letters.

Cation-π Interactions as Determinants for Binding of the Compatible Solutes Glycine Betaine and Proline Betaine by the Periplasmic Ligand-binding Protein ProX from Escherichia coli*

Kay Diederichs, Erhard Bremer, K. Diederichs, 2004, Journal of Biological Chemistry.

Structural Characterisation Reveals Mechanism of IL-13-Neutralising Monoclonal Antibody Tralokinumab as Inhibition of Binding to IL-13Rα1 and IL-13Rα2.

J. Breed, R. Minter, B. Popovic, 2017, Journal of molecular biology.

The structure of porin from Paracoccus denitrificans at 3.1 Å resolution

K. Diederichs, J. Breed, W. Welte, 1997, FEBS letters.

Crystal structure analysis of the exocytosis-sensitive phosphoprotein, pp63/parafusin (phosphoglucomutase), from Paramecium reveals significant conformational variability.

K. Diederichs, K. Hauser, R. Kissmehl, 2002, Journal of molecular biology.

Seven-helix bundles: molecular modeling via restrained molecular dynamics.

M. Sansom, J. Breed, I. Kerr, 1995, Biophysical journal.

A novel method for structure-based prediction of ion channel conductance properties.

G. R. Smith, M S Sansom, G R Smith, 1997, Biophysical journal.

Polarity-dependent conformational switching of a peptide mimicking the S4-S5 linker of the voltage-sensitive sodium channel.

J. Breed, O. Helluin, H. Duclohier, 1996, Biochimica et biophysica acta.

A study of the reactivity of S(VI)-F containing warheads with nucleophilic amino-acid side chains under physiological conditions.

A. Whitty, J. Breed, J. Debreczeni, 2017, Organic & biomolecular chemistry.

Purification, crystallization and preliminary crystallographic analysis of the periplasmic binding protein ProX from Escherichia coli.

J. Breed, W. Welte, E. Bremer, 2001 .

Water in channel-like cavities: structure and dynamics.

M. Sansom, J. Breed, I. Kerr, 1996, Biophysical journal.

Computational Design of Epitope-Specific Functional Antibodies.

Yanay Ofran, Guy Nimrod, Sharon Fischman, 2018, Cell reports.

Simulation studies of alamethicin-bilayer interactions.

J. Breed, M. Sansom, H. Son, 1997, Biophysical journal.

KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe

P. Kolasinska-Zwierz, J. Breed, J. Debreczeni, 2019, Nature Communications.

Discovery of AZD9833, a potent and orally bioavailable selective estrogen receptor degrader and antagonist.

O. Delpuech, J. Breed, J. Nissink, 2020, Journal of medicinal chemistry.

Molecular determinants for substrate specificity of the ligand-binding protein OpuAC from Bacillus subtilis for the compatible solutes glycine betaine and proline betaine.

J. Breed, W. Welte, E. Bremer, 2006, Journal of molecular biology.

Adventures in Scaffold Morphing: Discovery of Fused Ring Heterocyclic Checkpoint Kinase 1 (CHK1) Inhibitors.

J. Breed, P. Lyne, J. Janetka, 2018, Journal of Medicinal Chemistry.

Molecular dynamics simulations of water within models of ion channels.

M S Sansom, J. Breed, M. Sansom, 1996, Biophysical journal.

Alamethicin channels in a membrane: molecular dynamics simulations.

H. Berendsen, D. Tieleman, J. Breed, 1998, Faraday discussions.

Engineering stabilized ion channels: covalent dimers of alamethicin.

J. Breed, M. Sansom, S. Peng, 1996, Biochemistry.

Variation of Enzyme and Cellular Potency with Substituents R 1 , R 2 , and R 3 As Indicated

Andrew G. Leach, J. Breed, D. M. Andrews, 2012 .

Intrinsic rectification of ion flux in alamethicin channels: studies with an alamethicin dimer.

K. Crowhurst, P. Biggin, J. Breed, 1997, Biophysical journal.

Building Bridges in a Series of Estrogen Receptor Degraders: An Application of Metathesis in Medicinal Chemistry.

J. Breed, J. Nissink, Paul R. J. Davey, 2019, ACS medicinal chemistry letters.

Discovery of a Potent and Orally Bioavailable Zwitterionic Series of Selective Estrogen Receptor Degrader-Antagonists.

J. Breed, J. Nissink, Paul R. J. Davey, 2023, Journal of medicinal chemistry.

Synthesis and evaluation of triazolones as checkpoint kinase 1 inhibitors.

Jon Read, Mei Su, J. Breed, 2012, Bioorganic & medicinal chemistry letters.

Discovery of a novel class of triazolones as checkpoint kinase inhibitors--hit to lead exploration.

J. Breed, V. Oza, P. Lyne, 2010, Bioorganic & medicinal chemistry letters.

Discovery of cofactor-specific, bactericidal Mycobacterium tuberculosis InhA inhibitors using DNA-encoded library technology

Christoph E. Dumelin, A. Keefe, J. Breed, 2016, Proceedings of the National Academy of Sciences.

Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRASG12C with Demonstrable CNS Penetration.

Doyle J Cassar, Nichola L. Davies, J. Breed, 2023, Journal of medicinal chemistry.

A study of the reactivity of S(VI)-F containing warheads with nucleophilic amino-acid side chains under physiological conditions.

J. Breed, J. Debreczeni, B. Aquila, 2017, Organic & biomolecular chemistry.

Three-dimensional structure of the nonaheme cytochrome c from Desulfovibrio desulfuricans Essex in the Fe(III) state at 1.89 A resolution.

K. Diederichs, J. Breed, W. Welte, 2001, Biochemistry.

Alamethicin channels - modelling via restrained molecular dynamics simulations.

P. Biggin, J. Breed, M. Sansom, 1997, Biochimica et biophysica acta.

Molecular modelling of Staphylococcal δ-toxin ion channels by restrained molecular dynamics

J. Breed, M. Sansom, I. Kerr, 1996 .

Ion channel stability and hydrogen bonding. Molecular modelling of channels formed by synthetic alamethicin analogues.

J. Breed, M. Sansom, I. Kerr, 1997, Biochimica et biophysica acta.