P. Nielsen

Peter E. Nielsen, Vadim V. Demidov, Maxim D. Frank-Kamenetskii, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Peptide nucleic acid: a versatile tool in genetic diagnostics and molecular biology.

P. Nielsen, P E Nielsen, 2001, Current opinion in biotechnology.

Dissecting direct and indirect readout of cAMP receptor protein DNA binding using an inosine and 2,6-diaminopurine in vitro selection system

P. Nielsen, Søren Lindemose, N. Møllegaard, 2008, Nucleic acids research.

Effects of diaminopurine and inosine substitutions on A-tract induced DNA curvature. Importance of the 3'-A-tract junction.

M. Waring, C. Bailly, P. Nielsen, 1997, Nucleic acids research.

Antisense Research and Application

G. Schultz, P. Nielsen, R. Zhang, 1998, Handbook of Experimental Pharmacology.

Increased DNA binding and sequence discrimination of PNA oligomers containing 2,6-diaminopurine.

P. Nielsen, L. Christensen, O. Dahl, 1997, Nucleic acids research.

Single base pair mutation analysis by PNA directed PCR clamping.

M. Egholm, P. Nielsen, O. Buchardt, 1993, Nucleic acids research.

DNA unwinding upon strand-displacement binding of a thymine-substituted polyamide to double-stranded DNA.

M. Egholm, P. Nielsen, M. Frank-Kamenetskii, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Selective oxidative halogenation of uracils

P. Nielsen, O. Buchardt, P. Ebbesen, 1993 .

Potent Inhibition of Late Stages of Hepadnavirus Replication by a Modified Cell Penetrating Peptide

F. Zoulim, P. Nielsen, M. Kann, 2012, PloS one.

Role of Cell-Penetrating Peptides in Intracellular Delivery of Peptide Nucleic Acids Targeting Hepadnaviral Replication

P. Nielsen, L. Cova, B. Ndéboko, 2017, Molecular therapy. Nucleic acids.

Competitive singlet-singlet energy transfer and electron transfer activation of aryl azides: application to photo-cross-linking experiments

P. Nielsen, O. Buchardt, G. Schuster, 1988 .

Efficient pH-independent sequence-specific DNA binding by pseudoisocytosine-containing bis-PNA.

M. Egholm, P. Nielsen, O. Buchardt, 1995, Nucleic acids research.

Photoreaction of 8-methoxypsoralen with yeast-tRNAPhe. Identification of the major reaction sites.

P. Nielsen, V. Leick, 1985, European journal of biochemistry.

1,8-Naphthyridin-2(1H)-ones. Novel Bicyclic and Tricyclic Analogues of Thymine in Peptide Nucleic Acids (PNAs)

P. Nielsen, J. Kastrup, A. B. Eldrup, 2001 .

Peptide Nucleic Acid. A Molecule with Two Identities

Peter E. Nielsen, P. Nielsen, 1999 .

Sequence/structure selective thermal and photochemical cleavage of yeast‐tRNAPhe by UO 22+

P. Nielsen, N. Møllegaard, 1996, Journal of molecular recognition : JMR.

Psoralenamines. 3. Synthesis, pharmacological behavior, and DNA binding of 5-(aminomethyl)-8-methoxy-, 5-[[(3-aminopropyl)oxy]methyl]-, and 8-[(3-aminopropyl)oxy]psoralen derivatives.

B. Nordén, P. Nielsen, O. Buchardt, 1985, Journal of Medicinal Chemistry.

Conformational changes of yeast tRNAPhe upon interaction with intercalators probed by nuclease digestion.

P. Nielsen, 1981, Biochimica et Biophysica Acta.

Modified (PNA, 2'-O-methyl and phosphoramidate) anti-TAR antisense oligonucleotides as strong and specific inhibitors of in vitro HIV-1 reverse transcription.

J. Toulmé, P. Nielsen, S. Litvak, 1998, Nucleic acids research.

Enantiomeric cross-inhibition in the synthesis of oligonucleotides on a nonchiral template.

L. Orgel, P. Nielsen, J. Schmidt, 1997, Journal of the American Chemical Society.

Peptide Nucleic Acid Probes for Sequence-Specific DNA Biosensors

Peter E. Nielsen, Joseph Wang, Haruki Shiraishi, 1996 .

An experimental study of mechanism and specificity of peptide nucleic acid (PNA) binding to duplex DNA.

V V Demidov, P. Nielsen, M. Frank-Kamenetskii, 1999, Journal of molecular biology.

Applications of peptide nucleic acids.

P. Nielsen, P E Nielsen, 1999, Current opinion in biotechnology.

Inhibition of translation and bacterial growth by peptide nucleic acid targeted to ribosomal RNA.

P. Nielsen, L. Good, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Sequence-selective DNA recognition by synthetic ligands.

P. Nielsen, P E Nielsen, Peter E. Nielsen, 1991, Bioconjugate chemistry.

Strand displacement recognition of mixed adenine-cytosine sequences in double stranded DNA by thymine-guanine PNA (peptide nucleic acid).

M. Egholm, P. Nielsen, P E Nielsen, 2001, Bioorganic & medicinal chemistry.

Modeling human disease by gene targeting.

P. Nielsen, S. P. Chambers, A. Dodd, 2004, Methods in cell biology.

Photochemical crosslinking of protein and DNA in chromatin. II. Synthesis and application of psoralen-cystamine-arylazido photocrosslinking reagents.

P. Nielsen, O. Buchardt, J. Møller, 1985, Analytical biochemistry.

Photofootprinting of drug-binding sites on DNA using diazo- and azido-9-aminoacridine derivatives.

P. Nielsen, C. Jeppesen, 1989, European journal of biochemistry.

Photocleavage of DNA and photofootprinting of E. coli RNA polymerase bound to promoter DNA by azido-9-acridinylamines

Peter E. Nielsen, C. Jeppesen, O. Buchardt, 1988, Nucleic Acids Res..

Applications of uranyl cleavage mapping of RNA structure.

P. Nielsen, N. Møllegaard, 2000, Methods in enzymology.

Uranyl photoprobing of DNA structures and drug-DNA complexes.

P. Nielsen, N. Møllegaard, 1997, Methods in molecular biology.

Uranyl photoprobing of a four‐way DNA junction: evidence for specific metal ion binding.

D. Lilley, A. Murchie, P. Nielsen, 1994, The EMBO journal.

DNA conformational analysis in solution by uranyl mediated photocleavage

Peter E. Nielsen, N. E. Mollegaard, C. Jeppesen, 1990, Nucleic Acids Res..

Uranyl mediated photofootprinting reveals strong E. coli RNA polymerase--DNA backbone contacts in the +10 region of the DeoP1 promoter open complex.

P. Nielsen, C. Jeppesen, 1989, Nucleic acids research.

Uranyl salts as photochemical agents for cleavage of DNA and probing of protein‐DNA contacts

P. Nielsen, O. Buchardt, C. Jeppesen, 1988, FEBS letters.

PSORALENAMINES. 3. SYNTHESIS, PHARMACOLOGICAL BEHAVIOR, AND DNA BINDING OF 5-(AMINOMETHYL)-8-METHOXY-, 5-(((3-AMINOPROPYL)OXY)METHYL)- AND 8-((3-AMINOPROPYL)OXY)PSORALEN DERIVATIVES

B. Nordén, P. Nielsen, O. Buchardt, 1985 .

Pseudocomplementary PNAs as selective modifiers of protein activity on duplex DNA: the case of type IIs restriction enzymes.

Peter E Nielsen, P. Nielsen, M. Frank-Kamenetskii, 2003, Nucleic acids research.

Unique properties of purine/pyrimidine asymmetric PNA.DNA duplexes: differential stabilization of PNA.DNA duplexes by purines in the PNA strand.

P. Nielsen, Anjana Sen, 2006, Biophysical journal.

On the stability of peptide nucleic acid duplexes in the presence of organic solvents

P. Nielsen, Anjana Sen, 2007, Nucleic acids research.

DNA analogues with nonphosphodiester backbones.

P. Nielsen, P E Nielsen, 1995, Annual review of biophysics and biomolecular structure.

Solid‐Phase synthesis of peptide nucleic acids

R. H. Berg, M. Egholm, P. Nielsen, 1995, Journal of peptide science : an official publication of the European Peptide Society.

Information transfer from peptide nucleic acids to RNA by template-directed syntheses.

L. Orgel, P. Nielsen, J. Schmidt, 1997, Nucleic acids research.

9-Acridinylpeptides and 9-acridinyl-4-nitrophenylsulfonylpeptides. Synthesis, binding to DNA, and photoinduced DNA cleavage.

P. Nielsen, O. Buchardt, M. Meldal, 2009, International journal of peptide and protein research.

Sequence-specific purification of nucleic acids by PNA-controlled hybrid selection.

Christopher B. Stanley, P. Nielsen, H. Ørum, 1995, BioTechniques.

Electric and flow linear dichroism of unfolded and condensed chromatin: a comparative study at low and intermediate ionic strength.

B. Nordén, P. Colson, P. Nielsen, 1989, Journal of biomolecular structure & dynamics.

Competitive Singlet-Singlet Energy Transfer and Electron Transfer Activation of Aryl Azides: Application to Photo-Cross-Linking Experiments.

P. Nielsen, O. Buchardt, G. Schuster, 1989 .

Synthesis of pyrrolidinone PNA: a novel conformationally restricted PNA analogue.

S. Pitsch, P. Nielsen, G. Zuccarello, 2001, The Journal of organic chemistry.

Photochemical Studies. XXII. Photochemical Ring-opening of Pyridine N-Oxide to 5-Oxo-2-pentenenitrile and/or 5-Oxo-3-pentenenitrile. A Reassignment of Structure.

C. Lohse, P. Nielsen, O. Buchardt, 1980 .

Thermal chemistry of podophyllotoxin in ethanol and a comparison of the cytostatic activity of the thermolysis products.

P. Nielsen, O. Buchardt, H. Hansen, 1986, Journal of pharmaceutical sciences.

PNA as Specific Probe for In Situ Hybridization to Metaphase Chromosomes

P. Nielsen, B. Lomholt, S. Frederiksen, 2000 .

Peptide nucleic acid (PNA): A model structure for the primordial genetic material?

P. Nielsen, Peter Egil Nielsen, 1993, Origins of life and evolution of the biosphere.

Antisense peptide nucleic acids.

P. Nielsen, 2000, Current opinion in molecular therapeutics.

RNA modifications by oxidation: a novel disease mechanism?

P. Nielsen, T. Henriksen, T. Mandrup-Poulsen, 2012, Free radical biology & medicine.

Development of Strategies for the Site-Specific In Vivo Incorporation of Photoreactive Amino Acids: p-Azidophenylalanine, p-Acetylphenylalanine and Benzofuranylalanine

P. Nielsen, C. Behrens, M. Ibba, 2000 .

PNA-mediated modulation and redirection of Her-2 pre-mRNA splicing: specific skipping of erbB-2 exon 19 coding for the ATP catalytic domain.

P. Nielsen, Takehiko Shiraishi, S. Pankratova, 2010, International journal of oncology.

Sequence-selective targeting of duplex DNA by peptide nucleic acids.

P. Nielsen, 2010, Current opinion in molecular therapeutics.

Calcium ions effectively enhance the effect of antisense peptide nucleic acids conjugated to cationic tat and oligoarginine peptides.

P. Nielsen, Takehiko Shiraishi, S. Pankratova, 2005, Chemistry & biology.

Effective photo-enhancement of cellular activity of fluorophore-octaarginine antisense PNA conjugates correlates with singlet oxygen formation, endosomal escape and chromophore lipophilicity

P. Nielsen, Takehiko Shiraishi, Reza Yarani, 2018, Scientific Reports.

Improved cellular activity of antisense peptide nucleic acids by conjugation to a cationic peptide-lipid (CatLip) domain.

P. Nielsen, V. Zachar, Takehiko Shiraishi, 2008, Bioconjugate chemistry.

Photochemically enhanced cellular delivery of cell penetrating peptide‐PNA conjugates

P. Nielsen, Takehiko Shiraishi, 2006, FEBS letters.

Peptide nucleic acid (PNA) cell penetrating peptide (CPP) conjugates as carriers for cellular delivery of antisense oligomers

Peter E. Nielsen, P. Nielsen, Takehiko Shiraishi, 2011, Artificial DNA, PNA & XNA.

Targeted gene repair facilitated by peptide nucleic acids (PNA).

P. Nielsen, 2010, Chembiochem : a European journal of chemical biology.

Antisense inhibition of gene expression in bacteria by PNA targeted to mRNA

P. Nielsen, L. Good, 1998, Nature Biotechnology.

Cyclobutyl-carbonyl substituted PNA: synthesis and study of a novel PNA derivative

P. Nielsen, V. Branchadell, R. Ortuño, 2006 .

In Vivo Administration of Splice Switching PNAs Using the mdx Mouse as a Model System.

P. Nielsen, Camilla Brolin, E. Lim, 2020, Methods in molecular biology.

Emergence of protocellular growth laws

Steen Rasmussen, Peter E Nielsen, P. Nielsen, 2007, Philosophical Transactions of the Royal Society B: Biological Sciences.

Activation of the Cpx-envelope stress response system promotes tolerance to antibacterials delivered by arginine-rich peptides and aminoglycosides in Escherichia coli

P. Nielsen, M. Otterlei, J. Frimodt-Møller, 2020, bioRxiv.

The many faces of PNA

Peter E. Nielsen, P. Nielsen, 2003, Letters in Peptide Science.

Combined triplex/duplex invasion of double-stranded DNA by "tail-clamp" peptide nucleic acid.

Peter E Nielsen, Thomas Bentin, P. Nielsen, 2003, Biochemistry.

Targeting double stranded DNA with peptide nucleic acid (PNA).

P. Nielsen, 2001, Current medicinal chemistry.

Evidence for (PNA)2/DNA triplex structure upon binding of PNA to dsDNA by strand displacement

M. Egholm, P. Nielsen, O. Buchardt, 1994, Journal of molecular recognition : JMR.

Antisense PNA effects in Escherichia coli are limited by the outer-membrane LPS layer.

C. Wahlestedt, P. Nielsen, O. Larsson, 2000, Microbiology.

Antisense properties of peptide nucleic acid.

P. Nielsen, H. J. Larsen, T. Bentin, 1999, Biochimica et biophysica acta.

Progress in developing PNA as a gene-targeted drug.

P. Nielsen, L. Good, P E Nielsen, 1997, Antisense & nucleic acid drug development.

Kinetics for hybridization of peptide nucleic acids (PNA) with DNA and RNA studied with the BIAcore technique.

B. Nordén, P. Nielsen, H. Ørum, 1997, Biochemistry.

Screening for genetic mutations

L. Tsui, J. Zieleński, B. Nordén, 1996, Nature.

Identification and characterization of genomic nucleosome-positioning sequences.

D M Crothers, D. Crothers, J. Kahn, 1997, Journal of molecular biology.

Repair of 8-methoxypsoralen induced DNA interstrand cross-links in Tetrahymena thermophila. The effect of inhibitors of macromolecular synthesis.

P. Nielsen, L. Kober, 1985, Mutation research.

REPAIR OF 8‐METHOXYPSORALEN INDUCED DNA INTERSTRAND CROSS‐LINKS IN Tetrahymena thermophila

P. Nielsen, Lars Køosber, 1984 .

PNA technology

Peter E. Nielsen, P. Nielsen, 2004, Molecular biotechnology.

Transcription-mediated binding of peptide nucleic acid (PNA) to double-stranded DNA: sequence-specific suicide transcription.

P. Nielsen, P E Nielsen, H J Larsen, 1996, Nucleic acids research.

Targeting of the Essential acpP, ftsZ, and rne Genes in Carbapenem-Resistant Acinetobacter baumannii by Antisense PNA Precision Antibacterials

P. Nielsen, N. Shahrokhi, A. J. Nejad, 2021, Biomedicines.

Structural transitions of chromatin at low salt concentrations: a flow linear dichroism study.

B. Nordén, P. Nielsen, T. Härd, 1985, Biochemistry.

DNA-like double helix formed by peptide nucleic acid

Peter E. Nielsen, M. Egholm, P. Nielsen, 1994, Nature.

56 Combinedaphy and Fluorescence in situ Hybridization (MAR-FISH) for the Identification of Metabolically Active

P. Nielsen, M. L. Nielsen, 2010 .

Detection of point mutations in DNA by PNA-based quartz-crystal biosensor

B. Nordén, B. Kasemo, P. Nielsen, 2000 .

Thermodynamics of sequence-specific binding of PNA to DNA.

B. Nordén, P. Nielsen, A. Holmen, 2000, Biochemistry.

Detection of point mutation in the p53 gene using a peptide nucleic acid biosensor

Gustavo Rivas, Peter E. Nielsen, Joseph Wang, 1997 .

Solution structure of a peptide nucleic acid–DNA duplex

P. Nielsen, M. Eriksson, 1996, Nature Structural Biology.

Sequence selective double strand DNA cleavage by peptide nucleic acid (PNA) targeting using nuclease S1.

M. Egholm, P. Nielsen, M. Frank-Kamenetskii, 1993, Nucleic acids research.

A formula for thermal stability (Tm) prediction of PNA/DNA duplexes.

P. Nielsen, C. Berding, H. Ørum, 1998, Nucleic acids research.

PD-loop: a complex of duplex DNA with an oligonucleotide.

V V Demidov, P. Nielsen, M. Frank-Kamenetskii, 1998, Proceedings of the National Academy of Sciences of the United States of America.

ON THE DNA BENDING BY PSORALEN INTERSTRAND CROSSLINKING. A GEL ELECTROPHORETIC STUDY

P. Nielsen, O. Buchardt, O. Dahl, 1988, Photochemistry and photobiology.

Thermodynamics of the Melting of PNA2/DNA Triple Helices

P. Nielsen, Y. Lazurkin, O. V. Krupnik, 2001, Journal of biomolecular structure & dynamics.

Toward peptide nucleic acid (PNA) directed peptide translation using ester based aminoacyl transfer.

R. Corradini, P. Nielsen, Valentina Bagnacani, 2014, ACS chemical biology.

Stepwise unfolding of chromatin by urea. A flow linear dichroism and photoaffinity labeling study.

B. Nordén, P. Nielsen, Y. Matsuoka, 1985, European journal of biochemistry.

PNA-DNA hybridization study using labeled streptavidin by voltammetry and surface plasmon fluorescence spectroscopy.

W. Knoll, P. Nielsen, Jianyun Liu, 2006, Analytical chemistry.

PNA-nucleic acid complexes. Structure, stability and dynamics

P. Nielsen, M. Eriksson, 1996, Quarterly Reviews of Biophysics.

Hybridization of peptide nucleic acid.

B. Nordén, P. Nielsen, L. Christensen, 1998, Biochemistry.

CHEMISTRY, PROPERTIES AND APPLICATIONS OF PNA (PEPTIDE NUCLEIC ACID)

P. Nielsen, K. L. Dueholm, 1997 .

Role of SbmA in the uptake of peptide nucleic acid (PNA)-peptide conjugates in E. coli.

Peter E Nielsen, P. Nielsen, J. Stach, 2013, ACS chemical biology.

Phosphate Selective Uranyl Photo‐Affinity Cleavage of Proteins. Determination of Phosphorylation Sites

P. Nielsen, B. Kragelund, N. Møllegaard, 2008, Chembiochem : a European journal of chemical biology.

Peptide nucleic acids (PNA) derived from N-(N-methylaminoethyl)glycine. Synthesis, hybridization and structural properties

B. Nordén, P. Nielsen, J. Kastrup, 1999 .

Peptide nucleic acids (PNAs): potential antisense and anti-gene agents.

M. Egholm, P. Nielsen, O. Buchardt, 1993, Anti-cancer drug design.

Enzyme-Triggered Release of the Antisense Octaarginine-PNA Conjugate from Phospholipase A2 Sensitive Liposomes

P. Nielsen, M. Ghavami, Takehiko Shiraishi, 2020 .

Targeted correction of a thalassemia-associated β-globin mutation induced by pseudo-complementary peptide nucleic acids

P. Glazer, P. Nielsen, R. Kole, 2009, Nucleic acids research.

Psoralen photofootprinting of protein‐binding sites on DNA

P. Nielsen, C. Jeppesen, W. Zhen, 1988, FEBS letters.

Label‐Free Bioelectronic Detection of Point Mutation by Using Peptide Nucleic Acid Probes

D. Ozkan, P. Kara, K. Kerman, 2003 .

Kinetic sequence discrimination of cationic bis-PNAs upon targeting of double-stranded DNA.

V V Demidov, P. Nielsen, M. Frank-Kamenetskii, 1998, Nucleic acids research.

Introducing Artificial DNA: PNA & XNA

P. Nielsen, 2010, Artificial DNA, PNA & XNA.

Efficiency of cellular delivery of antisense peptide nucleic acid by electroporation depends on charge and electroporation geometry.

J. Gehl, P. Nielsen, B. Agerholm-Larsen, 2011, Oligonucleotides.

Evaluation of transfection protocols for unmodified and modified peptide nucleic acid (PNA) oligomers.

P. Nielsen, V. Zachar, P. Ebbesen, 2006, Oligonucleotides.

Analysis of various sequence-specific triplexes by electron and atomic force microscopies.

P. Nielsen, D. Cherny, E. Delain, 1998, Biophysical journal.

Nucleic Acid Backbone Structure Variations: Peptide Nucleic Acids

P. Nielsen, 2014 .

Efficient in vitro inhibition of HIV-1 gag reverse transcription by peptide nucleic acid (PNA) at minimal ratios of PNA/RNA.

P. Nielsen, V. Zachar, P. Ebbesen, 1997, Nucleic acids research.

Enhanced peptide nucleic acid binding to supercoiled DNA: possible implications for DNA "breathing" dynamics.

P. Nielsen, P E Nielsen, T Bentin, 1996, Biochemistry.

Peptide nucleic acid.DNA strand displacement loops as artificial transcription promoters.

M. Egholm, P. Nielsen, O. Buchardt, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Enhanced cellular delivery of cell-penetrating peptide-peptide nucleic acid conjugates by photochemical internalization.

P. Nielsen, Takehiko Shiraishi, 2011, Methods in molecular biology.

Inhibition of Staphylococcus aureus gene expression and growth using antisense peptide nucleic acids.

S. Awasthi, P. Nielsen, L. Good, 2004, Molecular therapy : the journal of the American Society of Gene Therapy.

Gene delivery by a steroid‐peptide nucleic acid conjugate

P. Nielsen, F. Frey, A. Bernasconi, 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

6-azidobenzo[a]pyrene. A photoactive derivative of benzo[a]pyrene for photoaffinity labeling

P. Nielsen, K. Straub, 1979 .

Simultaneously amplified electrochemical and surface plasmon optical detection of DNA hybridization based on ferrocene-streptavidin conjugates.

Louis Tiefenauer, Wolfgang Knoll, Jianyun Liu, 2005, Analytical chemistry.

In vivo footprinting: studies of protein--DNA interactions in gene regulation.

P. Nielsen, 1989, BioEssays : news and reviews in molecular, cellular and developmental biology.

Hydrogen bonding versus stacking stabilization by modified nucleobases incorporated in PNA.DNA duplexes.

P. Nielsen, Anjana Sen, 2009, Biophysical chemistry.

Photofootprinting Analysis of Protein-DNA Interactions

P. Nielsen, C. Jeppesen, 1989 .

Effect of secondary structure on the thermodynamics and kinetics of PNA hybridization to DNA hairpins.

P. Nielsen, J. Seifert, B. Armitage, 2001, Journal of the American Chemical Society.

Measurement of PNA binding to double-stranded DNA.

P. Nielsen, G. I. Hansen, T. Bentin, 2002, Methods in molecular biology.

PNA Length Restriction of Antibacterial Activity of Peptide-PNA Conjugates in Escherichia coli Through Effects of the Inner Membrane

P. Nielsen, A. Ghosal, Lise Goltermann, 2019, Front. Microbiol..

DNA binding and cleavage by a cationic manganese porphyrin-peptide nucleic acid conjugate.

P. Nielsen, P. Bigey, B. Meunier, 1997, Bioconjugate chemistry.

Peptide nucleic acid (PNA). A DNA mimic with a pseudopeptide backbone

Peter E. Nielsen, P. Nielsen, Gerald Haaima, 2010 .

Induced Chirality in PNA-PNA Duplexes

B. Nordén, P. Nielsen, M. Eriksson, 1995 .

Peptide nucleic acids and their potential applications in biotechnology.

R. H. Berg, M. Egholm, P. Nielsen, 1993, Trends in biotechnology.

The translation start codon region is sensitive to antisense PNA inhibition in Escherichia coli.

P. Nielsen, L. Good, G. Rajarao, 2003, Oligonucleotides.

Targeting TdT gene expression in Molt-4 cells by PNA-octaarginine conjugates.

P. Nielsen, M. Hejazi, Ç. Avcı, 2020, International journal of biological macromolecules.

Antibiotic-free bacterial strain selection using antisense peptide nucleic acid.

P. Nielsen, L. Good, N. Nekhotiaeva, 2003, BioTechniques.

Open Access Research Article Modulation of Mdm2 Pre-mrna Splicing by 9-aminoacridine-pna (peptide Nucleic Acid) Conjugates Targeting Intron-exon Junctions

P. Nielsen, Takehiko Shiraishi, Jonhard Eysturskarð, 2022 .

Ionic Effects on the Stability and Conformation of Peptide Nucleic Acid Complexes

Peter E. Nielsen, Astrid Gräslund, Munna Sarkar, 1996 .

Modulation of the pharmacokinetic properties of PNA: preparation of galactosyl, mannosyl, fucosyl, N-acetylgalactosaminyl, and N-acetylglucosaminyl derivatives of aminoethylglycine peptide nucleic acid monomers and their incorporation into PNA oligomers.

B. Tavitian, P. Nielsen, F. Dollé, 2003, Bioconjugate chemistry.

High-affinity triplex targeting of double stranded DNA using chemically modified peptide nucleic acid oligomers

P. Nielsen, T. Bentin, Mads E. Hansen, 2009, Nucleic acids research.

Superior duplex DNA strand invasion by acridine conjugated peptide nucleic acids.

P. Nielsen, T. Bentin, 2003, Journal of the American Chemical Society.

Kinetics and mechanism of polyamide ("peptide") nucleic acid binding to duplex DNA.

V V Demidov, P. Nielsen, M. Frank-Kamenetskii, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Electron microscopy mapping of oligopurine tracts in duplex DNA by peptide nucleic acid targeting.

V V Demidov, P. Nielsen, D. Cherny, 1994, Nucleic acids research.

Molecular flexibility of extended and compacted polynucleosomes

B. Nordén, P. Nielsen, T. Härd, 1988, European Biophysics Journal.

PNA Antisense Targeting in Bacteria: Determination of Antibacterial Activity (MIC) of PNA-Peptide Conjugates.

P. Nielsen, Lise Goltermann, 2020, Methods in molecular biology.

Antibacterial Peptide Nucleic Acid-Antimicrobial Peptide (PNA-AMP) Conjugates: Antisense Targeting of Fatty Acid Biosynthesis.

P. Nielsen, H. Franzyk, A. Hansen, 2016, Bioconjugate chemistry.

On the structure of active chromatin

B. Nordén, P. Nielsen, Y. Matsuoka, 1984, FEBS letters.

Label-free DNA electrochemical sensor based on a PNA-functionalized conductive polymer.

P. Nielsen, B. Piro, M. Pham, 2008, Talanta.

Reinterpretation of linear dichroism of chromatin supports a perpendicular linker orientation in the folded state.

B. Nordén, P. Nielsen, M. Kubista, 1990, Journal of biomolecular structure & dynamics.

Surface density dependence of PCR amplicon hybridization on PNA/DNA probe layers.

Danfeng Yao, Wolfgang Knoll, Peter E Nielsen, 2005, Biophysical journal.

Electrochemical detection of hybridization using peptide nucleic acids and methylene blue on self-assembled alkanethiol monolayer modified gold electrodes

J. Justin Gooding, Kagan Kerman, Peter E. Nielsen, 2002 .

Investigating the kinetics of DNA-DNA and PNA-DNA interactions using surface plasmon resonance-enhanced fluorescence spectroscopy.

W. Knoll, P. Nielsen, D. Kambhampati, 2001, Biosensors & bioelectronics.

A specific and efficient photoreaction between E. coli RNA polymerase and T+1 in the lacUV5 or deoP1 promoter.

P. Nielsen, K. Jensen, C. Jeppesen, 1988, Nucleic acids research.

Activating the Cpx response induces tolerance to antisense PNA delivered by an arginine-rich peptide in Escherichia coli

P. Nielsen, M. Otterlei, J. Frimodt-Møller, 2021, Molecular therapy. Nucleic acids.

Structural characterization of PNA-DNA duplexes by NMR. Evidence for DNA in a B-like conformation.

B. Nordén, P. Nielsen, O. Buchardt, 1994, Biochemistry.

Information transfer from DNA to peptide nucleic acids by template-directed syntheses.

L. Orgel, P. Nielsen, L. Christensen, 1997, Nucleic acids research.

Extended DNA-recognition repertoire of peptide nucleic acid (PNA): PNA-dsDNA triplex formed with cytosine-rich homopyrimidine PNA.

B. Nordén, P. Nielsen, P Wittung, 1997, Biochemistry.

Application of peptide nucleic acid in cancer therapy.

P. Nielsen, H. Knudsen, 1997, Anti-cancer drugs.

Protein crosslinking reagents containing a selenoethylene linker are cleaved by mild oxidation.

P. Nielsen, O. Buchardt, L. Petersen, 1986, Analytical biochemistry.

Azidobenzoyl-, azidoacridinyl-, diazocyclopentadienyl-carbonyl- and 8-propyloxypsoralen photobiotinylation reagents. Syntheses and photoreactions with DNA and protein

P. Nielsen, U. Henriksen, Ole Burchardt, 1991 .

Photolabeling Reagent Design

P. Nielsen, O. Buchardt, T. Koch, 1989 .

2012 Landes Bioscience. Do not distribute. Cell number and transfection volume dependent peptide nucleic acid antisense activity by cationic delivery methods

Peter Berthold, P. Nielsen, Takehiko Shiraishi, 2012 .

Peptide nucleic acid (PNA)

Peter E. Nielsen, P. Nielsen, 1999 .

Unique base-pair breathing dynamics in PNA-DNA hybrids.

P. Nielsen, A. Gräslund, M. Leijon, 1997, Journal of molecular biology.

Surface plasmon field-enhanced fluorescence spectroscopy in PCR product analysis by peptide nucleic acid probes.

Danfeng Yao, Wolfgang Knoll, Peter E Nielsen, 2004, Nucleic acids research.

Interaction of benz[a]pyrene diol epoxide with chromatin studied by flow linear dichroism

B. Nordén, P. Nielsen, B. Jernström, 1989, FEBS letters.

Flow linear dichroism supports an accordion model for the salt-induced condensation of chromatin.

B. Nordén, P. Nielsen, M. Kubista, 1988, Biochemical pharmacology.

STRAND DISPLACEMENT BINDING OF A DUPLEX-FORMING HOMOPURINE PNA TO A HOMOPYRIMIDINE DUPLEX DNA TARGET

Peter E. Nielsen, Leif Christensen, P. Nielsen, 1996 .

Uptake, Stability, and Activity of Antisense Anti-acpP PNA-Peptide Conjugates in Escherichia coli and the Role of SbmA.

P. Nielsen, Lise Goltermann, Niloofar Yavari, 2021, ACS chemical biology.

Antisense inhibition of the Escherichia coli NrdAB aerobic ribonucleotide reductase is bactericidal due to induction of DNA strand breaks

P. Nielsen, T. Thomsen, Godefroid Charbon, 2021, The Journal of antimicrobial chemotherapy.

A novel pseudo-complementary PNA G-C base pair

P. Nielsen, J. Nielsen, O. Dahl, 2011, Artificial DNA PNA & XNA.

Sequence-specific protection of duplex DNA against restriction and methylation enzymes by pseudocomplementary PNAs.

V V Demidov, P. Nielsen, M. Frank-Kamenetskii, 2000, Biochemistry.

Inhibition of PNA triplex formation by N4-benzoylated cytosine.

P. Nielsen, L. Christensen, H. Hansen, 1998, Nucleic acids research.

Modulating Gene Function with Peptide Nucleic Acids (PNA)

P. Nielsen, 2007 .

Structural and biological properties of peptide nucleic acid (PNA)

P. Nielsen, 1998 .

Cellular delivery and antisense effects of peptide nucleic acid conjugated to polyethyleneimine via disulfide linkers.

Peter Berthold, P. Nielsen, Takehiko Shiraishi, 2010, Bioconjugate chemistry.

Photoreactive Bicyclic Amino Acids as Substrates for Mutant Escherichia coli Phenylalanyl-tRNA Synthetases*

P. Nielsen, M. Ibba, H. Roy, 2004, Journal of Biological Chemistry.

Correction of a splice-site mutation in the beta-globin gene stimulated by triplex-forming peptide nucleic acids

Peter E Nielsen, P. Glazer, P. Nielsen, 2008, Proceedings of the National Academy of Sciences.

Peptide nucleic acids directed to the promoter of the alpha-chain of the interleukin-2 receptor.

A. Harel-Bellan, P. Nielsen, L. Pritchard, 1996, Biochimica et biophysica acta.

Operative Vaginal Delivery

P. Nielsen, S. Kilpatrick, H. Galan, 2007 .

Effect of temperature and ionic strength on the dissociation kinetics and lifetime of PNA-DNA triplexes.

P. Nielsen, Y. Lazurkin, D. Stetsenko, 2000, Biochemistry.

A new class of genome rare cutters

Peter E. Nielsen, Vadim V. Demidov, Alexei G. Veselkov, 1996, Nucleic Acids Res..

Segmentation of Rodent Whole-Body Dynamic PET Images: An Unsupervised Method Based on Voxel Dynamics

Vincent Frouin, Claude Comtat, Pascal Cathier, 2008, IEEE Transactions on Medical Imaging.

Reduction and Oxidation of Peptide Nucleic Acid and DNA at Mercury and Carbon Electrodes

Peter E. Nielsen, Libuše Trnková, L. Havran, 1999 .

Cellular uptake of adamantyl conjugated peptide nucleic acids.

P. Nielsen, H. Knudsen, T. Ljungstrøm, 1999, Bioconjugate chemistry.

Peptide nucleic acid-zirconium coordination nanoparticles

P. Nielsen, S. Wuttke, Ernst Wagner, 2023, Scientific reports.

Fluorescein-conjugated lysine monomers for solid phase synthesis of fluorescent peptides and PNA oligomers.

P. Nielsen, N. Harrit, O. Dahl, 1997, Bioconjugate chemistry.

Cellular Antisense Activity of PNA–Oligo(bicycloguanidinium) Conjugates Forming Self‐Assembled Nanoaggregates

P. Nielsen, Julián Valero, J. de Mendoza, 2015, Chembiochem : a European journal of chemical biology.

DIRECT ENANTIOMERIC SEPARATION OF N-AMINOETHYLAMINO ACIDS : DETERMINATION OF THE ENANTIOMERIC EXCESS OF CHIRAL PEPTIDE NUCLEIC ACIDS (PNAS) BY GC

R. Marchelli, R. Corradini, P. Nielsen, 1999 .

Effect of supercoiling on the λ switch

K. Sneppen, L. Oddershede, P. Nielsen, 2014, Bacteriophage.

Formation of oligonucleotide-PNA-chimeras by template-directed ligation.

L. Orgel, P. Nielsen, M. Koppitz, 1998, Journal of the American Chemical Society.

Synthesis of ‘retro-inverso’ peptide nucleic acids: 2. Oligomerization and stability

P. Nielsen, O. Buchardt, A. H. Krotz, 1995 .

Sequence Specific Recognition of Double Stranded DNA by Peptide Nucleic Acid

P. Nielsen, 1998 .

STRUCTURE-ACTIVITY STUDIES OF THE BINDING OF MODIFIED PEPTIDE NUCLEIC-ACIDS (PNAS) TO DNA

Peter E. Nielsen, M. Egholm, B. Nordén, 1994 .

A DNA minor groove electronegative potential genome map based on photo-chemical probing

P. Nielsen, Søren Lindemose, Morten Hansen, 2011, Nucleic acids research.