V. Tuohy

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Retired self-proteins as vaccine targets for primary immunoprevention of adult-onset cancers

V. Tuohy, 2014, Expert review of vaccines.

Mechanisms and Estrogenic Regulation Ventromedial Hypothalamic Neurons: Ionic Histamine-Induced Excitatory Responses in Mouse

D. Pfaff, L. Kow, V. Tuohy, 2015 .

Sensorineural Hearing Loss Cells in Patients with Autoimmune Increased Frequencies of Cochlin-Specific T Tuohy

C. Morton, V. Tuohy, N. G. Robertson, 2006 .

Increased Frequencies of Cochlin-Specific T Cells in Patients with Autoimmune Sensorineural Hearing Loss1

C. Morton, V. Tuohy, N. G. Robertson, 2006, The Journal of Immunology.

SWR/J Mice Autoimmune Disease in SWXJ, SJL/J, and Peptides That Mediate Organ-Specific A Novel Class II-Binding Motif Selects

V. Tuohy, D. Jane-wit, C. Moravec, 2002 .

Gene therapy for autoimmune demyelinating disease of the central nervous system.

V. Tuohy, P. M. Mathisen, 1999, Archivum immunologiae et therapiae experimentalis.

Th2 T cells expressing transgene PDGF-A serve as vectors for gene therapy in autoimmune demyelinating disease.

V. Tuohy, A. Nishiyama, J. M. Johnson, 1999, Journal of autoimmunity.

Treatment of Experimental Autoimmune Encephalomyelitis with Genetically Modified Memory T Cells

V. Tuohy, J. Drazba, Justin M. Johnson, 1997, The Journal of experimental medicine.

Astrocyte expression of mRNA encoding cytokines IP‐10 and JE/MCP‐1 in experimental autoimmune encephalomyelitis

R. Ransohoff, M. Stoler, V. Tuohy, 1993, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

In vivo effects of interferon beta-1a on immunosuppressive cytokines in multiple sclerosis

R. Rudick, R. Ransohoff, V. Tuohy, 1998, Neurology.

In situ hybridization analysis of glial fibrillary acidic protein mRNA reveals evidence of biphasic astrocyte activation during acute experimental autoimmune encephalomyelitis.

R. Ransohoff, M. Stoler, V. Tuohy, 1996, The American journal of pathology.

A method to generate enhanced GFP+ chimeric mice to study the role of bone marrow-derived cells in the eye.

Steven E. Wilson, V. Tuohy, V. Singh, 2013, Experimental eye research.

Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease☆

V. Tuohy, J. Peterson, S. Miller, 1990, Journal of Neuroimmunology.

An autoimmune-mediated strategy for prophylactic breast cancer vaccination

V. Tuohy, D. Jane-wit, C. Z. Altuntas, 2010, Nature Medicine.

Phosphodiesterase I, A Novel Adhesion Molecule and/or Cytokine Involved in Oligodendrocyte Function

V. Tuohy, B. Fuss, H. Baba, 1997, The Journal of Neuroscience.

Formulation of an ovarian cancer vaccine with the squalene-based AddaVax adjuvant inhibits the growth of murine epithelial ovarian carcinomas

V. Tuohy, Suparna Mazumder, N. Dvorina, 2022, Clinical and experimental vaccine research.

&bgr;1-Adrenergic Receptor Autoantibodies Mediate Dilated Cardiomyopathy by Agonistically Inducing Cardiomyocyte Apoptosis

V. Tuohy, Z. Popović, M. Penn, 2007, Circulation.

EAE induced by myelin proteolipid apoprotein (PLP) in various strains of mice

R. Sobel, V. Tuohy, M. Lees, 1987, Journal of Neuroimmunology.

Synchronous synthesis of alpha- and beta-chemokines by cells of diverse lineage in the central nervous system of mice with relapses of chronic experimental autoimmune encephalomyelitis.

R. Ransohoff, R. Strieter, V. Tuohy, 1997, The American journal of pathology.

Alterations in cardiac function and gene expression during autoimmune myocarditis in mice.

N. Ratliff, V. Tuohy, C. McTiernan, 2000, Journal of molecular and cellular cardiology.

Autoimmune cardiac-specific T cell responses in dilated cardiomyopathy.

V. Tuohy, D. Jane-wit, Dan Jane-wit, 2006, International journal of cardiology.

Treatment with Soluble Tumor Necrosis Factor Receptor (sTNFR):Fc/p80 Fusion Protein Ameliorates Relapsing-remitting Experimental Autoimmune Encephalomyelitis and Decreases Chemokine Expression

R. Ransohoff, V. Tuohy, K. Selmaj, 2004, Autoimmunity.

Macrophages with Induction of Tumor-Infiltrating Cell-Dependent Mechanism in Connection Anti-Renca Tumor Action via a T Sodium Stibogluconate Interacts with IL-2 in

M. Zhou, V. Tuohy, E. Borden, 2005 .

A predictable sequential determinant spreading cascade invariably accompanies progression of experimental autoimmune encephalomyelitis: a basis for peptide-specific therapy after onset of clinical disease

V. Tuohy, J. M. Johnson, Min Yu, 1996, The Journal of experimental medicine.

Autoimmune Targeted Disruption of the Pituitary-Ovarian Axis Causes Premature Ovarian Failure1

V. Tuohy, C. Z. Altuntas, Justin M. Johnson, 2006, The Journal of Immunology.

Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice.

R. Sobel, V. Tuohy, R. Laursen, 1989, Journal of immunology.

Myelin proteolipid protein-induced experimental allergic encephalomyelitis. Variations of disease expression in different strains of mice.

R. Sobel, V. Tuohy, M. Lees, 1988, Journal of immunology.

Interferon-γ production to inner ear antigens by T cells from patients with autoimmune sensorineural hearing loss

V. Tuohy, P. Williams, C. Solares, 2002, Journal of Neuroimmunology.

Peptide determinants of myelin proteolipid protein (PLP) in autoimmune demyelinating disease: A review

V. Tuohy, 1994, Neurochemical Research.

Sequence 104–117 of myelin proteolipid protein is a cryptic encephalitogenic T cell determinant for SJL/J mice

V. Tuohy, Dawn M. Thomas, 1995, Journal of Neuroimmunology.

Disruption of estrous cycle homeostasis in mice with experimental autoimmune encephalomyelitis

V. Tuohy, C. Z. Altuntas, R. Jaini, 2015, Journal of Neuroimmunology.

Determinant-regulated onset of experimental autoimmune encephalomyelitis: distinct epitopes of myelin proteolipid protein mediate either acute or delayed disease in SJL/J mice.

V. Tuohy, J. M. Johnson, T. Haqqi, 1995, Autoimmunity.

Acute Experimental Allergic Encephalomyelitis in SJL/J Mice Induced by a Synthetic Peptide of Myelin Proteolipid Protein

R. Sobel, V. Tuohy, R. Laursen, 1990, Journal of neuropathology and experimental neurology.

Expression of Chemokines RANTES, MIP-1α and GRO-α Correlates with Inflammation in Acute Experimental Autoimmune Encephalomyelitis

R. Ransohoff, V. Tuohy, A. Glabinski, 1998, Neuroimmunomodulation.

Expression of chemokines RANTES, MIP-1alpha and GRO-alpha correlates with inflammation in acute experimental autoimmune encephalomyelitis.

R. Ransohoff, V. Tuohy, A. Glabinski, 1998, Neuroimmunomodulation.

Synchronous Synthesis of a- and -Chemokines by Cells of Diverse Lineage in the Central Nervous System of Mice with Relapses of Chronic Experimental Autoimmune Encephalomyelitis

R. Ransohoff, R. Strieter, V. Tuohy, 2007 .

Autoimmune sensorineural hearing loss: an immunologic perspective

V. Tuohy, C. Solares, G. Hughes, 2003, Journal of Neuroimmunology.

Acute Experimental Allergic Encephalomyelitis in SJL/J Mice Induced by a Synthetic Peptide of Myelin Proteolipid Protein a

R. Sobel, V. Tuohy, R. Laursen, 1990 .

Treatment with BBB022A or rolipram stabilizes the blood-brain barrier in experimental autoimmune encephalomyelitis: an additional mechanism for the therapeutic effect of type IV phosphodiesterase inhibitors

V. A. Folcik, L. Rubin, R. Ransohoff, 1999, Journal of Neuroimmunology.

Epitope Spreading in EAE

V. Tuohy, A. Edling, 2005 .

Interferon-beta inhibits progression of relapsing-remitting experimental autoimmune encephalomyelitis.

B. Trapp, V. Tuohy, A. Nishiyama, 1996, Journal of neuroimmunology.

Gene-based intramuscular interferon-beta therapy for experimental autoimmune encephalomyelitis.

Robert M. Bernard, V. Tuohy, A. Luxembourg, 2006, Molecular therapy : the journal of the American Society of Gene Therapy.

Induction of Th17 Cells Adjuvant Relative to CpG Is Linked to Encephalitogenicity of Complete Freund's

V. Tuohy, P. Lehmann, M. Tary‐Lehmann, 2009 .

A prophylactic vaccine for breast cancer? Why not?

V. Tuohy, 2010, Breast Cancer Research.

Central Nervous System Chemokine mRNA Accumulation Follows Initial Leukocyte Entry at the Onset of Acute Murine Experimental Autoimmune Encephalomyelitis

R. Ransohoff, V. Tuohy, R. Tuthill, 1995, Brain, Behavior, and Immunity.

Development of reactivity to new myelin antigens during chronic relapsing autoimmune demyelination.

A. Cross, V. Tuohy, C. Raine, 1993, Cellular immunology.

Inhibition of murine relapsing experimental autoimmune encephalomyelitis by immune tolerance to proteolipid protein and its encephalitogenic peptides.

V. Tuohy, S. Miller, S. Miller, 1990, Journal of immunology.

Myelin antigen load influences antigen presentation and severity of central nervous system autoimmunity

V. Tuohy, C. Flask, W. Macklin, 2013, Journal of Neuroimmunology.

Self-determinants in autoimmune demyelinating disease: changes in T- cell response specificity.

V. Tuohy, A. Ben-nun, R. Fritz, 1994, Current opinion in immunology.

A synthetic peptide from myelin proteolipid protein induces experimental allergic encephalomyelitis.

R. Sobel, V. Tuohy, R. Laursen, 1988, Journal of immunology.

Central Nervous System Chemokine mRNA Accumulation Follows Initial Leukocyte Entry at the Onset of Acute Murine Experimental Autoimmune Encephalomyelitis

R. Ransohoff, V. Tuohy, R. Tuthill, 1995, Brain, Behavior, and Immunity.

Susceptibility to PLP‐Induced EAE Is Regulated by Non‐H‐2 Genes a

R. Sobel, V. Tuohy, M. Lees, 1988, Annals of the New York Academy of Sciences.

Myelin proteolipid protein: minimum sequence requirements for active induction of autoimmune encephalomyelitis in SWR/J and SJL/J mice

R. Sobel, V. Tuohy, R. Laursen, 1992, Journal of Neuroimmunology.

Epitope-determined patterns of clinical disease in experimental autoimmune encephalomyelitis (EAE)

V. Tuohy, D. M. Thomas, 1994, Journal of Neuroimmunology.

Murine experimental autoimmune encephalomyelitis: a model of immune-mediated inflammation and multiple sclerosis.

R. Ransohoff, V. Tuohy, A. Glabinski, 1997, Methods in enzymology.

Lower urinary tract phenotype of experimental autoimmune cystitis in mouse: a potential animal model for interstitial cystitis

V. Tuohy, G. Gasbarro, F. Daneshgari, 2008, BJU international.

A novel murine model of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) induced by immunization with a spermine binding protein (p25) peptide.

V. Tuohy, F. Daneshgari, Ç. Şakalar, 2013, American journal of physiology. Regulatory, integrative and comparative physiology.

Parental MHC molecule haplotype expression in (SJL/J x SWR)F1 mice with acute experimental allergic encephalomyelitis induced with two different synthetic peptides of myelin proteolipid protein.

R. Sobel, V. Tuohy, M. Lees, 1991, Journal of immunology.

Sex-defined T-cell responses to cardiac self determine differential outcomes of murine dilated cardiomyopathy.

V. Tuohy, D. Jane-wit, T. Forsthuber, 2008, The American journal of pathology.

The epitope spreading cascade during progression of experimental autoimmune encephalomyelitis and multiple sclerosis

R. Kinkel, V. Tuohy, Justin M. Johnson, 1998, Immunological reviews.

Encephalitogenicity of Complete Freund’s Adjuvant Relative to CpG Is Linked to Induction of Th17 Cells

V. Tuohy, P. Lehmann, M. Tary‐Lehmann, 2009, The Journal of Immunology.

Vaccination with inhibin-α provides effective immunotherapy against testicular stromal cell tumors

V. Tuohy, Justin M. Johnson, R. Aguilar, 2017, Journal of Immunotherapy for Cancer.

Regulation and function of central nervous system chemokines

R. Ransohoff, M. Stoler, V. Tuohy, 1995, International Journal of Developmental Neuroscience.

Astrocyte-restricted ablation of interleukin-17-induced Act1-mediated signaling ameliorates autoimmune encephalomyelitis.

R. Ransohoff, V. Tuohy, N. Giltiay, 2010, Immunity.

Pertussis Toxin-Induced Reversible Encephalopathy Dependent on Monocyte Chemoattractant Protein-1 Overexpression in Mice

B. Rollins, R. Ransohoff, V. Tuohy, 2002, The Journal of Neuroscience.

HLA-DP: a class II restriction molecule involved in epitope spreading during the development of multiple sclerosis.

R. Kinkel, B. Weinstock-Guttman, V. Tuohy, 1998, Human immunology.

Axon Loss in the Spinal Cord Determines Permanent Neurological Disability in an Animal Model of Multiple Sclerosis

B. Trapp, R. Ransohoff, C. Bjartmar, 2002, Journal of neuropathology and experimental neurology.

IFN-γ and IL-17 Production in Experimental Autoimmune Encephalomyelitis Depends on Local APC–T Cell Complement Production1

V. Tuohy, Robert H Miller, P. Heeger, 2008, The Journal of Immunology.

The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis.

C. A. de la Motte, V. Tuohy, Caixia Ma, 2007, Immunity.

Chronic pelvic allodynia is mediated by CCL2 through mast cells in an experimental autoimmune cystitis model.

V. Tuohy, F. Daneshgari, F. Bicer, 2015, American journal of physiology. Renal physiology.

Uroplakin Peptide-Specific Autoimmunity Initiates Interstitial Cystitis/Painful Bladder Syndrome in Mice

V. Tuohy, F. Daneshgari, Ç. Şakalar, 2013, PloS one.

Autoimmunity to uroplakin II causes cystitis in mice: a novel model of interstitial cystitis.

V. Tuohy, F. Daneshgari, Ç. Şakalar, 2012, European urology.

Targeting Antigen-Specific T Cells for Gene Therapy of Autoimmune Disease

V. Tuohy, Justin M. Johnson, Justin M Johnson, 2005 .

Human and murine lymphocyte neurotrophin expression is confined to B cells

V. Tuohy, A. Edling, Justin M. Johnson, 2004, Journal of neuroscience research.

The type IV phosphodiesterase specific inhibitor mesopram inhibits experimental autoimmune encephalomyelitis in rodents

Henry Laurent, Dieter Seidelmann, Gerald Kirsch, 2000, Journal of Neuroimmunology.

Combination of sunitinib with anti‐tumor vaccination inhibits T cell priming and requires careful scheduling to achieve productive immunotherapy

J. Finke, V. Tuohy, P. Rayman, 2014, International journal of cancer.

Immunotherapy in breast cancer: an overview of current strategies and perspectives

L. Buisseret, V. Tuohy, M. Piccart-Gebhart, 2023, npj Breast Cancer.

Connective tissue and its growth factor CTGF distinguish the morphometric and molecular remodeling of the bladder in a model of neurogenic bladder.

V. Tuohy, F. Daneshgari, Ç. Şakalar, 2012, American journal of physiology. Renal physiology.

Prophylactic cancer vaccination by targeting functional non-self

V. Tuohy, R. Jaini, 2011, Annals of medicine.

Spontaneous Regression of Primary Autoreactivity during Chronic Progression of Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis

V. Tuohy, Min Yu, L. Yin, 1999, The Journal of experimental medicine.

Autoimmunity and premature ovarian failure

V. Tuohy, C. Z. Altuntas, 2007, Current opinion in obstetrics & gynecology.

Monocytes in active multiple sclerosis: intact regulation of HLA-DR density in vitro despite decreased HLA-DR density in vivo

R. Rudick, R. Ransohoff, V. Tuohy, 1992, Journal of Neuroimmunology.

Modulation of the IL-10/IL-12 cytokine circuit by interferon-β inhibits the development of epitope spreading and disease progression in murine autoimmune encephalomyelitis

V. Tuohy, Justin M. Johnson, Min Yu, 2000, Journal of Neuroimmunology.

Interferon-β inhibits progression of relapsing-remitting experimental autoimmune encephalomyelitis

B. Trapp, V. Tuohy, A. Nishiyama, 1996, Journal of Neuroimmunology.

T cell design for therapy in autoimmune demyelinating disease

V. Tuohy, P. M. Mathisen, 2000, Journal of Neuroimmunology.

Gene therapy for autoimmune diseases

V. Tuohy, P. M. Mathisen, 2000 .

Immunotherapy of ovarian cancer with a monoclonal antibody specific for the extracellular domain of anti-Müllerian hormone receptor II

A. Komar, V. Tuohy, Justin M. Johnson, 2020, Oncotarget.

The adaptor Act1 is required for interleukin 17–dependent signaling associated with autoimmune and inflammatory disease

V. Tuohy, N. Giltiay, Jianhua Xiao, 2007, Nature Immunology.

Diversity and plasticity of self recognition during the development of multiple sclerosis.

R. Kinkel, B. Weinstock-Guttman, V. Tuohy, 1997, The Journal of clinical investigation.

Stem cell reconstitution of autoimmune T cell repertoires

V. Tuohy, A. Edling, 2005, Journal of Neuroimmunology.

A Novel Class II-Binding Motif Selects Peptides That Mediate Organ-Specific Autoimmune Disease in SWXJ, SJL/J, and SWR/J Mice1

V. Tuohy, D. Jane-wit, C. Moravec, 2002, The Journal of Immunology.

Regression and spreading of self-recognition during the development of autoimmune demyelinating disease.

V. Tuohy, P. Kinkel, Min Yu, 1999, Journal of autoimmunity.

Immunosuppressive therapy for autoimmune inner ear disease.

V. Tuohy, P. Weber, Katie Geelan-Hansen, 2009, Immunotherapy.

Autoimmune mediated regulation of ovarian tumor growth.

V. Tuohy, C. Flask, M. Dutertre, 2012, Gynecologic oncology.

[13] Murine experimental autoimmune encephalomyelitis: A model of immune-mediated inflammation and multiple sclerosis

R. Ransohoff, V. Tuohy, M. Tani, 1997 .

Experimental autoimmune breast failure: a model for lactation insufficiency, postnatal nutritional deprivation, and prophylactic breast cancer vaccination.

V. Tuohy, Ç. Şakalar, C. Z. Altuntas, 2012, The American journal of pathology.

Murine autoimmune hearing loss mediated by CD4+ T cells specific for inner ear peptides.

V. Tuohy, C. Solares, G. Hughes, 2004, The Journal of clinical investigation.

Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells

Klaus-Armin Nave, K. Nave, M. Klugmann, 2000, Nature Medicine.

Sodium Stibogluconate Interacts with IL-2 in Anti-Renca Tumor Action via a T Cell-Dependent Mechanism in Connection with Induction of Tumor-Infiltrating Macrophages1

V. Tuohy, E. Borden, D. Lindner, 2005, The Journal of Immunology.

Visinin-like Protein (VILIP) Is a Neuron-specific Calcium-dependent Double-stranded RNA-binding Protein*

V. Tuohy, Justin M. Johnson, P. M. Mathisen, 1999, The Journal of Biological Chemistry.

Gene therapy in the treatment of autoimmune disease.

V. Tuohy, P. M. Mathisen, 1998, Immunology today.

Pre-Emptive Targeting of the Epitope Spreading Cascade with Genetically Modified Regulatory T Cells During Autoimmune Demyelinating Disease1

V. Tuohy, A. Edling, Justin M. Johnson, 2001, The Journal of Immunology.

Demyelinating Disease Regulatory T Cells During Autoimmune Modified Spreading Cascade with Genetically Pre-Emptive Targeting of the Epitope

V. Tuohy, A. Edling, Justin M. Johnson, 2001 .

The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation.

V. Tuohy, Greg M. Delgoffe, J. Powell, 2010, Immunity.

Gene Therapy in Experimental Autoimmune Encephalomyelitis

V. Tuohy, P. M. Mathisen, 2000, Journal of Clinical Immunology.

Bench-to-bedside challenges in developing immune protection against breast cancer

V. Tuohy, 2014, Cleveland Clinic Journal of Medicine.

Normal and reactive NG2+ glial cells are distinct from resting and activated microglia

V. Tuohy, J. Drazba, A. Nishiyama, 1997, Journal of neuroscience research.

Primary Immunoprevention of Epithelial Ovarian Carcinoma by Vaccination against the Extracellular Domain of Anti-Müllerian Hormone Receptor II

V. Tuohy, N. Dvorina, J. Ko, 2017, Cancer Prevention Research.

Targeted Vaccination against Human α-Lactalbumin for Immunotherapy and Primary Immunoprevention of Triple Negative Breast Cancer

V. Tuohy, E. Downs-Kelly, R. Jaini, 2016, Cancers.

Regulation of Murine Ovarian Epithelial Carcinoma by Vaccination against the Cytoplasmic Domain of Anti-Müllerian Hormone Receptor II

V. Tuohy, Ç. Şakalar, D. Connolly, 2015, Journal of immunology research.

IRAK4 Kinase Activity Is Required for Th17 Differentiation and Th17-Mediated Disease1

V. Tuohy, N. Brooks, R. Gilmour, 2009, The Journal of Immunology.

Differentiation and Th 17-Mediated Disease IRAK 4 Kinase Activity Is Required for Th 17 Tuohy

V. Tuohy, N. Brooks, R. Gilmour, 2009 .

Epitope spreading: a mechanism for progression of autoimmune disease.

R. Kinkel, V. Tuohy, 2000, Archivum immunologiae et therapiae experimentalis.

Differential DM20 mRNA expression distinguishes two distinct patterns of spontaneous recovery from murine autoimmune encephalomyelitis

V. Tuohy, Min Yu, P. M. Mathisen, 2001, Journal of neuroscience research.

In vitro and in vivo inhibition of mitogen‐driven T‐cell activation by recombinant interferon beta

R. Rudick, R. Ransohoff, V. Tuohy, 1993, Neurology.

T-cell design: optimizing the therapeutic potential of autoreactive T cells by genetic modification

V. Tuohy, P. M. Mathisen, 1998 .

Generation of autonomously pathogenic neo‐autoreactive TH1 cells during the development of the determinant spreading cascade in murine autoimmune encephalomyelitis

V. Tuohy, M. Yu, J. Johnson, 1996, Journal of neuroscience research.

Bladder dysfunction in mice with experimental autoimmune encephalomyelitis

V. Tuohy, F. Daneshgari, Guiming Liu, 2008, Journal of Neuroimmunology.

Digitized image analysis reveals diffuse abnormalities in normal‐appearing white matter during acute experimental autoimmune encephalomyelitis

V. Tuohy, B. Fuss, J. Drazba, 1998 .

V. Tuohy, J. M. Johnson, Min Yu, 1996, The Journal of experimental medicine.

Primary immunoprevention of adult onset cancers by vaccinating against retired tissue-specific self-proteins.

V. Tuohy, S. Mazumder, Justin M Johnson, 2020, Seminars in immunology.

The neocortical-immune axis

V. Tuohy, 2005, Journal of Neuroimmunology.